                         SEQUENCE LISTING

<110>  CureVac AG
 
<120>  RNA for cancer therapy

<130>  CU01P232WO1

<160>  1062  

<170>  PatentIn version 3.5

<210>  1
<211>  288
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PDCD1

<400>  1

Met Gln Ile Pro Gln Ala Pro Trp Pro Val Val Trp Ala Val Leu Gln 
1               5                   10                  15      


Leu Gly Trp Arg Pro Gly Trp Phe Leu Asp Ser Pro Asp Arg Pro Trp 
            20                  25                  30          


Asn Pro Pro Thr Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp 
        35                  40                  45              


Asn Ala Thr Phe Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe Val 
    50                  55                  60                  


Leu Asn Trp Tyr Arg Met Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala 
65                  70                  75                  80  


Ala Phe Pro Glu Asp Arg Ser Gln Pro Gly Gln Asp Cys Arg Phe Arg 
                85                  90                  95      


Val Thr Gln Leu Pro Asn Gly Arg Asp Phe His Met Ser Val Val Arg 
            100                 105                 110         


Ala Arg Arg Asn Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Ser Leu 
        115                 120                 125             


Ala Pro Lys Ala Gln Ile Lys Glu Ser Leu Arg Ala Glu Leu Arg Val 
    130                 135                 140                 


Thr Glu Arg Arg Ala Glu Val Pro Thr Ala His Pro Ser Pro Ser Pro 
145                 150                 155                 160 


Arg Pro Ala Gly Gln Phe Gln Thr Leu Val Val Gly Val Val Gly Gly 
                165                 170                 175     


Leu Leu Gly Ser Leu Val Leu Leu Val Trp Val Leu Ala Val Ile Cys 
            180                 185                 190         


Ser Arg Ala Ala Arg Gly Thr Ile Gly Ala Arg Arg Thr Gly Gln Pro 
        195                 200                 205             


Leu Lys Glu Asp Pro Ser Ala Val Pro Val Phe Ser Val Asp Tyr Gly 
    210                 215                 220                 


Glu Leu Asp Phe Gln Trp Arg Glu Lys Thr Pro Glu Pro Pro Val Pro 
225                 230                 235                 240 


Cys Val Pro Glu Gln Thr Glu Tyr Ala Thr Ile Val Phe Pro Ser Gly 
                245                 250                 255     


Met Gly Thr Ser Ser Pro Ala Arg Arg Gly Ser Ala Asp Gly Pro Arg 
            260                 265                 270         


Ser Ala Gln Pro Leu Arg Pro Glu Asp Gly His Cys Ser Trp Pro Leu 
        275                 280                 285             


<210>  2
<211>  149
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PDCD1(1-149)

<400>  2

Met Gln Ile Pro Gln Ala Pro Trp Pro Val Val Trp Ala Val Leu Gln 
1               5                   10                  15      


Leu Gly Trp Arg Pro Gly Trp Phe Leu Asp Ser Pro Asp Arg Pro Trp 
            20                  25                  30          


Asn Pro Pro Thr Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp 
        35                  40                  45              


Asn Ala Thr Phe Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe Val 
    50                  55                  60                  


Leu Asn Trp Tyr Arg Met Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala 
65                  70                  75                  80  


Ala Phe Pro Glu Asp Arg Ser Gln Pro Gly Gln Asp Cys Arg Phe Arg 
                85                  90                  95      


Val Thr Gln Leu Pro Asn Gly Arg Asp Phe His Met Ser Val Val Arg 
            100                 105                 110         


Ala Arg Arg Asn Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Ser Leu 
        115                 120                 125             


Ala Pro Lys Ala Gln Ile Lys Glu Ser Leu Arg Ala Glu Leu Arg Val 
    130                 135                 140                 


Thr Glu Arg Arg Ala 
145                 


<210>  3
<211>  219
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IL12A

<400>  3

Met Cys Pro Ala Arg Ser Leu Leu Leu Val Ala Thr Leu Val Leu Leu 
1               5                   10                  15      


Asp His Leu Ser Leu Ala Arg Asn Leu Pro Val Ala Thr Pro Asp Pro 
            20                  25                  30          


Gly Met Phe Pro Cys Leu His His Ser Gln Asn Leu Leu Arg Ala Val 
        35                  40                  45              


Ser Asn Met Leu Gln Lys Ala Arg Gln Thr Leu Glu Phe Tyr Pro Cys 
    50                  55                  60                  


Thr Ser Glu Glu Ile Asp His Glu Asp Ile Thr Lys Asp Lys Thr Ser 
65                  70                  75                  80  


Thr Val Glu Ala Cys Leu Pro Leu Glu Leu Thr Lys Asn Glu Ser Cys 
                85                  90                  95      


Leu Asn Ser Arg Glu Thr Ser Phe Ile Thr Asn Gly Ser Cys Leu Ala 
            100                 105                 110         


Ser Arg Lys Thr Ser Phe Met Met Ala Leu Cys Leu Ser Ser Ile Tyr 
        115                 120                 125             


Glu Asp Leu Lys Met Tyr Gln Val Glu Phe Lys Thr Met Asn Ala Lys 
    130                 135                 140                 


Leu Leu Met Asp Pro Lys Arg Gln Ile Phe Leu Asp Gln Asn Met Leu 
145                 150                 155                 160 


Ala Val Ile Asp Glu Leu Met Gln Ala Leu Asn Phe Asn Ser Glu Thr 
                165                 170                 175     


Val Pro Gln Lys Ser Ser Leu Glu Glu Pro Asp Phe Tyr Lys Thr Lys 
            180                 185                 190         


Ile Lys Leu Cys Ile Leu Leu His Ala Phe Arg Ile Arg Ala Val Thr 
        195                 200                 205             


Ile Asp Arg Val Met Ser Tyr Leu Asn Ala Ser 
    210                 215                 


<210>  4
<211>  219
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IL12A(1-219)

<400>  4

Met Cys Pro Ala Arg Ser Leu Leu Leu Val Ala Thr Leu Val Leu Leu 
1               5                   10                  15      


Asp His Leu Ser Leu Ala Arg Asn Leu Pro Val Ala Thr Pro Asp Pro 
            20                  25                  30          


Gly Met Phe Pro Cys Leu His His Ser Gln Asn Leu Leu Arg Ala Val 
        35                  40                  45              


Ser Asn Met Leu Gln Lys Ala Arg Gln Thr Leu Glu Phe Tyr Pro Cys 
    50                  55                  60                  


Thr Ser Glu Glu Ile Asp His Glu Asp Ile Thr Lys Asp Lys Thr Ser 
65                  70                  75                  80  


Thr Val Glu Ala Cys Leu Pro Leu Glu Leu Thr Lys Asn Glu Ser Cys 
                85                  90                  95      


Leu Asn Ser Arg Glu Thr Ser Phe Ile Thr Asn Gly Ser Cys Leu Ala 
            100                 105                 110         


Ser Arg Lys Thr Ser Phe Met Met Ala Leu Cys Leu Ser Ser Ile Tyr 
        115                 120                 125             


Glu Asp Leu Lys Met Tyr Gln Val Glu Phe Lys Thr Met Asn Ala Lys 
    130                 135                 140                 


Leu Leu Met Asp Pro Lys Arg Gln Ile Phe Leu Asp Gln Asn Met Leu 
145                 150                 155                 160 


Ala Val Ile Asp Glu Leu Met Gln Ala Leu Asn Phe Asn Ser Glu Thr 
                165                 170                 175     


Val Pro Gln Lys Ser Ser Leu Glu Glu Pro Asp Phe Tyr Lys Thr Lys 
            180                 185                 190         


Ile Lys Leu Cys Ile Leu Leu His Ala Phe Arg Ile Arg Ala Val Thr 
        195                 200                 205             


Ile Asp Arg Val Met Ser Tyr Leu Asn Ala Ser 
    210                 215                 


<210>  5
<211>  197
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IL12A(23-219)

<400>  5

Arg Asn Leu Pro Val Ala Thr Pro Asp Pro Gly Met Phe Pro Cys Leu 
1               5                   10                  15      


His His Ser Gln Asn Leu Leu Arg Ala Val Ser Asn Met Leu Gln Lys 
            20                  25                  30          


Ala Arg Gln Thr Leu Glu Phe Tyr Pro Cys Thr Ser Glu Glu Ile Asp 
        35                  40                  45              


His Glu Asp Ile Thr Lys Asp Lys Thr Ser Thr Val Glu Ala Cys Leu 
    50                  55                  60                  


Pro Leu Glu Leu Thr Lys Asn Glu Ser Cys Leu Asn Ser Arg Glu Thr 
65                  70                  75                  80  


Ser Phe Ile Thr Asn Gly Ser Cys Leu Ala Ser Arg Lys Thr Ser Phe 
                85                  90                  95      


Met Met Ala Leu Cys Leu Ser Ser Ile Tyr Glu Asp Leu Lys Met Tyr 
            100                 105                 110         


Gln Val Glu Phe Lys Thr Met Asn Ala Lys Leu Leu Met Asp Pro Lys 
        115                 120                 125             


Arg Gln Ile Phe Leu Asp Gln Asn Met Leu Ala Val Ile Asp Glu Leu 
    130                 135                 140                 


Met Gln Ala Leu Asn Phe Asn Ser Glu Thr Val Pro Gln Lys Ser Ser 
145                 150                 155                 160 


Leu Glu Glu Pro Asp Phe Tyr Lys Thr Lys Ile Lys Leu Cys Ile Leu 
                165                 170                 175     


Leu His Ala Phe Arg Ile Arg Ala Val Thr Ile Asp Arg Val Met Ser 
            180                 185                 190         


Tyr Leu Asn Ala Ser 
        195         


<210>  6
<211>  328
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IL12B

<400>  6

Met Cys His Gln Gln Leu Val Ile Ser Trp Phe Ser Leu Val Phe Leu 
1               5                   10                  15      


Ala Ser Pro Leu Val Ala Ile Trp Glu Leu Lys Lys Asp Val Tyr Val 
            20                  25                  30          


Val Glu Leu Asp Trp Tyr Pro Asp Ala Pro Gly Glu Met Val Val Leu 
        35                  40                  45              


Thr Cys Asp Thr Pro Glu Glu Asp Gly Ile Thr Trp Thr Leu Asp Gln 
    50                  55                  60                  


Ser Ser Glu Val Leu Gly Ser Gly Lys Thr Leu Thr Ile Gln Val Lys 
65                  70                  75                  80  


Glu Phe Gly Asp Ala Gly Gln Tyr Thr Cys His Lys Gly Gly Glu Val 
                85                  90                  95      


Leu Ser His Ser Leu Leu Leu Leu His Lys Lys Glu Asp Gly Ile Trp 
            100                 105                 110         


Ser Thr Asp Ile Leu Lys Asp Gln Lys Glu Pro Lys Asn Lys Thr Phe 
        115                 120                 125             


Leu Arg Cys Glu Ala Lys Asn Tyr Ser Gly Arg Phe Thr Cys Trp Trp 
    130                 135                 140                 


Leu Thr Thr Ile Ser Thr Asp Leu Thr Phe Ser Val Lys Ser Ser Arg 
145                 150                 155                 160 


Gly Ser Ser Asp Pro Gln Gly Val Thr Cys Gly Ala Ala Thr Leu Ser 
                165                 170                 175     


Ala Glu Arg Val Arg Gly Asp Asn Lys Glu Tyr Glu Tyr Ser Val Glu 
            180                 185                 190         


Cys Gln Glu Asp Ser Ala Cys Pro Ala Ala Glu Glu Ser Leu Pro Ile 
        195                 200                 205             


Glu Val Met Val Asp Ala Val His Lys Leu Lys Tyr Glu Asn Tyr Thr 
    210                 215                 220                 


Ser Ser Phe Phe Ile Arg Asp Ile Ile Lys Pro Asp Pro Pro Lys Asn 
225                 230                 235                 240 


Leu Gln Leu Lys Pro Leu Lys Asn Ser Arg Gln Val Glu Val Ser Trp 
                245                 250                 255     


Glu Tyr Pro Asp Thr Trp Ser Thr Pro His Ser Tyr Phe Ser Leu Thr 
            260                 265                 270         


Phe Cys Val Gln Val Gln Gly Lys Ser Lys Arg Glu Lys Lys Asp Arg 
        275                 280                 285             


Val Phe Thr Asp Lys Thr Ser Ala Thr Val Ile Cys Arg Lys Asn Ala 
    290                 295                 300                 


Ser Ile Ser Val Arg Ala Gln Asp Arg Tyr Tyr Ser Ser Ser Trp Ser 
305                 310                 315                 320 


Glu Trp Ala Ser Val Pro Cys Ser 
                325             


<210>  7
<211>  328
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IL12B(1-328)

<400>  7

Met Cys His Gln Gln Leu Val Ile Ser Trp Phe Ser Leu Val Phe Leu 
1               5                   10                  15      


Ala Ser Pro Leu Val Ala Ile Trp Glu Leu Lys Lys Asp Val Tyr Val 
            20                  25                  30          


Val Glu Leu Asp Trp Tyr Pro Asp Ala Pro Gly Glu Met Val Val Leu 
        35                  40                  45              


Thr Cys Asp Thr Pro Glu Glu Asp Gly Ile Thr Trp Thr Leu Asp Gln 
    50                  55                  60                  


Ser Ser Glu Val Leu Gly Ser Gly Lys Thr Leu Thr Ile Gln Val Lys 
65                  70                  75                  80  


Glu Phe Gly Asp Ala Gly Gln Tyr Thr Cys His Lys Gly Gly Glu Val 
                85                  90                  95      


Leu Ser His Ser Leu Leu Leu Leu His Lys Lys Glu Asp Gly Ile Trp 
            100                 105                 110         


Ser Thr Asp Ile Leu Lys Asp Gln Lys Glu Pro Lys Asn Lys Thr Phe 
        115                 120                 125             


Leu Arg Cys Glu Ala Lys Asn Tyr Ser Gly Arg Phe Thr Cys Trp Trp 
    130                 135                 140                 


Leu Thr Thr Ile Ser Thr Asp Leu Thr Phe Ser Val Lys Ser Ser Arg 
145                 150                 155                 160 


Gly Ser Ser Asp Pro Gln Gly Val Thr Cys Gly Ala Ala Thr Leu Ser 
                165                 170                 175     


Ala Glu Arg Val Arg Gly Asp Asn Lys Glu Tyr Glu Tyr Ser Val Glu 
            180                 185                 190         


Cys Gln Glu Asp Ser Ala Cys Pro Ala Ala Glu Glu Ser Leu Pro Ile 
        195                 200                 205             


Glu Val Met Val Asp Ala Val His Lys Leu Lys Tyr Glu Asn Tyr Thr 
    210                 215                 220                 


Ser Ser Phe Phe Ile Arg Asp Ile Ile Lys Pro Asp Pro Pro Lys Asn 
225                 230                 235                 240 


Leu Gln Leu Lys Pro Leu Lys Asn Ser Arg Gln Val Glu Val Ser Trp 
                245                 250                 255     


Glu Tyr Pro Asp Thr Trp Ser Thr Pro His Ser Tyr Phe Ser Leu Thr 
            260                 265                 270         


Phe Cys Val Gln Val Gln Gly Lys Ser Lys Arg Glu Lys Lys Asp Arg 
        275                 280                 285             


Val Phe Thr Asp Lys Thr Ser Ala Thr Val Ile Cys Arg Lys Asn Ala 
    290                 295                 300                 


Ser Ile Ser Val Arg Ala Gln Asp Arg Tyr Tyr Ser Ser Ser Trp Ser 
305                 310                 315                 320 


Glu Trp Ala Ser Val Pro Cys Ser 
                325             


<210>  8
<211>  306
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IL12B(23-328)

<400>  8

Ile Trp Glu Leu Lys Lys Asp Val Tyr Val Val Glu Leu Asp Trp Tyr 
1               5                   10                  15      


Pro Asp Ala Pro Gly Glu Met Val Val Leu Thr Cys Asp Thr Pro Glu 
            20                  25                  30          


Glu Asp Gly Ile Thr Trp Thr Leu Asp Gln Ser Ser Glu Val Leu Gly 
        35                  40                  45              


Ser Gly Lys Thr Leu Thr Ile Gln Val Lys Glu Phe Gly Asp Ala Gly 
    50                  55                  60                  


Gln Tyr Thr Cys His Lys Gly Gly Glu Val Leu Ser His Ser Leu Leu 
65                  70                  75                  80  


Leu Leu His Lys Lys Glu Asp Gly Ile Trp Ser Thr Asp Ile Leu Lys 
                85                  90                  95      


Asp Gln Lys Glu Pro Lys Asn Lys Thr Phe Leu Arg Cys Glu Ala Lys 
            100                 105                 110         


Asn Tyr Ser Gly Arg Phe Thr Cys Trp Trp Leu Thr Thr Ile Ser Thr 
        115                 120                 125             


Asp Leu Thr Phe Ser Val Lys Ser Ser Arg Gly Ser Ser Asp Pro Gln 
    130                 135                 140                 


Gly Val Thr Cys Gly Ala Ala Thr Leu Ser Ala Glu Arg Val Arg Gly 
145                 150                 155                 160 


Asp Asn Lys Glu Tyr Glu Tyr Ser Val Glu Cys Gln Glu Asp Ser Ala 
                165                 170                 175     


Cys Pro Ala Ala Glu Glu Ser Leu Pro Ile Glu Val Met Val Asp Ala 
            180                 185                 190         


Val His Lys Leu Lys Tyr Glu Asn Tyr Thr Ser Ser Phe Phe Ile Arg 
        195                 200                 205             


Asp Ile Ile Lys Pro Asp Pro Pro Lys Asn Leu Gln Leu Lys Pro Leu 
    210                 215                 220                 


Lys Asn Ser Arg Gln Val Glu Val Ser Trp Glu Tyr Pro Asp Thr Trp 
225                 230                 235                 240 


Ser Thr Pro His Ser Tyr Phe Ser Leu Thr Phe Cys Val Gln Val Gln 
                245                 250                 255     


Gly Lys Ser Lys Arg Glu Lys Lys Asp Arg Val Phe Thr Asp Lys Thr 
            260                 265                 270         


Ser Ala Thr Val Ile Cys Arg Lys Asn Ala Ser Ile Ser Val Arg Ala 
        275                 280                 285             


Gln Asp Arg Tyr Tyr Ser Ser Ser Trp Ser Glu Trp Ala Ser Val Pro 
    290                 295                 300                 


Cys Ser 
305     


<210>  9
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker-sFvCC49-218

<400>  9

Gly Ser Thr Ser Gly Ser Gly Lys Pro Gly Ser Gly Glu Gly Ser Thr 
1               5                   10                  15      


Lys Gly 
        


<210>  10
<211>  543
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IL12

<400>  10

Met Cys His Gln Gln Leu Val Ile Ser Trp Phe Ser Leu Val Phe Leu 
1               5                   10                  15      


Ala Ser Pro Leu Val Ala Ile Trp Glu Leu Lys Lys Asp Val Tyr Val 
            20                  25                  30          


Val Glu Leu Asp Trp Tyr Pro Asp Ala Pro Gly Glu Met Val Val Leu 
        35                  40                  45              


Thr Cys Asp Thr Pro Glu Glu Asp Gly Ile Thr Trp Thr Leu Asp Gln 
    50                  55                  60                  


Ser Ser Glu Val Leu Gly Ser Gly Lys Thr Leu Thr Ile Gln Val Lys 
65                  70                  75                  80  


Glu Phe Gly Asp Ala Gly Gln Tyr Thr Cys His Lys Gly Gly Glu Val 
                85                  90                  95      


Leu Ser His Ser Leu Leu Leu Leu His Lys Lys Glu Asp Gly Ile Trp 
            100                 105                 110         


Ser Thr Asp Ile Leu Lys Asp Gln Lys Glu Pro Lys Asn Lys Thr Phe 
        115                 120                 125             


Leu Arg Cys Glu Ala Lys Asn Tyr Ser Gly Arg Phe Thr Cys Trp Trp 
    130                 135                 140                 


Leu Thr Thr Ile Ser Thr Asp Leu Thr Phe Ser Val Lys Ser Ser Arg 
145                 150                 155                 160 


Gly Ser Ser Asp Pro Gln Gly Val Thr Cys Gly Ala Ala Thr Leu Ser 
                165                 170                 175     


Ala Glu Arg Val Arg Gly Asp Asn Lys Glu Tyr Glu Tyr Ser Val Glu 
            180                 185                 190         


Cys Gln Glu Asp Ser Ala Cys Pro Ala Ala Glu Glu Ser Leu Pro Ile 
        195                 200                 205             


Glu Val Met Val Asp Ala Val His Lys Leu Lys Tyr Glu Asn Tyr Thr 
    210                 215                 220                 


Ser Ser Phe Phe Ile Arg Asp Ile Ile Lys Pro Asp Pro Pro Lys Asn 
225                 230                 235                 240 


Leu Gln Leu Lys Pro Leu Lys Asn Ser Arg Gln Val Glu Val Ser Trp 
                245                 250                 255     


Glu Tyr Pro Asp Thr Trp Ser Thr Pro His Ser Tyr Phe Ser Leu Thr 
            260                 265                 270         


Phe Cys Val Gln Val Gln Gly Lys Ser Lys Arg Glu Lys Lys Asp Arg 
        275                 280                 285             


Val Phe Thr Asp Lys Thr Ser Ala Thr Val Ile Cys Arg Lys Asn Ala 
    290                 295                 300                 


Ser Ile Ser Val Arg Ala Gln Asp Arg Tyr Tyr Ser Ser Ser Trp Ser 
305                 310                 315                 320 


Glu Trp Ala Ser Val Pro Cys Ser Gly Ser Thr Ser Gly Ser Gly Lys 
                325                 330                 335     


Pro Gly Ser Gly Glu Gly Ser Thr Lys Gly Arg Asn Leu Pro Val Ala 
            340                 345                 350         


Thr Pro Asp Pro Gly Met Phe Pro Cys Leu His His Ser Gln Asn Leu 
        355                 360                 365             


Leu Arg Ala Val Ser Asn Met Leu Gln Lys Ala Arg Gln Thr Leu Glu 
    370                 375                 380                 


Phe Tyr Pro Cys Thr Ser Glu Glu Ile Asp His Glu Asp Ile Thr Lys 
385                 390                 395                 400 


Asp Lys Thr Ser Thr Val Glu Ala Cys Leu Pro Leu Glu Leu Thr Lys 
                405                 410                 415     


Asn Glu Ser Cys Leu Asn Ser Arg Glu Thr Ser Phe Ile Thr Asn Gly 
            420                 425                 430         


Ser Cys Leu Ala Ser Arg Lys Thr Ser Phe Met Met Ala Leu Cys Leu 
        435                 440                 445             


Ser Ser Ile Tyr Glu Asp Leu Lys Met Tyr Gln Val Glu Phe Lys Thr 
    450                 455                 460                 


Met Asn Ala Lys Leu Leu Met Asp Pro Lys Arg Gln Ile Phe Leu Asp 
465                 470                 475                 480 


Gln Asn Met Leu Ala Val Ile Asp Glu Leu Met Gln Ala Leu Asn Phe 
                485                 490                 495     


Asn Ser Glu Thr Val Pro Gln Lys Ser Ser Leu Glu Glu Pro Asp Phe 
            500                 505                 510         


Tyr Lys Thr Lys Ile Lys Leu Cys Ile Leu Leu His Ala Phe Arg Ile 
        515                 520                 525             


Arg Ala Val Thr Ile Asp Arg Val Met Ser Tyr Leu Asn Ala Ser 
    530                 535                 540             


<210>  11
<211>  261
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD40LG

<400>  11

Met Ile Glu Thr Tyr Asn Gln Thr Ser Pro Arg Ser Ala Ala Thr Gly 
1               5                   10                  15      


Leu Pro Ile Ser Met Lys Ile Phe Met Tyr Leu Leu Thr Val Phe Leu 
            20                  25                  30          


Ile Thr Gln Met Ile Gly Ser Ala Leu Phe Ala Val Tyr Leu His Arg 
        35                  40                  45              


Arg Leu Asp Lys Ile Glu Asp Glu Arg Asn Leu His Glu Asp Phe Val 
    50                  55                  60                  


Phe Met Lys Thr Ile Gln Arg Cys Asn Thr Gly Glu Arg Ser Leu Ser 
65                  70                  75                  80  


Leu Leu Asn Cys Glu Glu Ile Lys Ser Gln Phe Glu Gly Phe Val Lys 
                85                  90                  95      


Asp Ile Met Leu Asn Lys Glu Glu Thr Lys Lys Glu Asn Ser Phe Glu 
            100                 105                 110         


Met Gln Lys Gly Asp Gln Asn Pro Gln Ile Ala Ala His Val Ile Ser 
        115                 120                 125             


Glu Ala Ser Ser Lys Thr Thr Ser Val Leu Gln Trp Ala Glu Lys Gly 
    130                 135                 140                 


Tyr Tyr Thr Met Ser Asn Asn Leu Val Thr Leu Glu Asn Gly Lys Gln 
145                 150                 155                 160 


Leu Thr Val Lys Arg Gln Gly Leu Tyr Tyr Ile Tyr Ala Gln Val Thr 
                165                 170                 175     


Phe Cys Ser Asn Arg Glu Ala Ser Ser Gln Ala Pro Phe Ile Ala Ser 
            180                 185                 190         


Leu Cys Leu Lys Ser Pro Gly Arg Phe Glu Arg Ile Leu Leu Arg Ala 
        195                 200                 205             


Ala Asn Thr His Ser Ser Ala Lys Pro Cys Gly Gln Gln Ser Ile His 
    210                 215                 220                 


Leu Gly Gly Val Phe Glu Leu Gln Pro Gly Ala Ser Val Phe Val Asn 
225                 230                 235                 240 


Val Thr Asp Pro Ser Gln Val Ser His Gly Thr Gly Phe Thr Ser Phe 
                245                 250                 255     


Gly Leu Leu Lys Leu 
            260     


<210>  12
<211>  867
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  PDCD1 CDS mRNA wild type

<400>  12
augcagaucc cacaggcgcc cuggccaguc gucugggcgg ugcuacaacu gggcuggcgg       60

ccaggauggu ucuuagacuc cccagacagg cccuggaacc cccccaccuu cuccccagcc      120

cugcucgugg ugaccgaagg ggacaacgcc accuucaccu gcagcuucuc caacacaucg      180

gagagcuucg ugcuaaacug guaccgcaug agccccagca accagacgga caagcuggcc      240

gcuuuccccg aggaccgcag ccagcccggc caggacugcc gcuuccgugu cacacaacug      300

cccaacgggc gugacuucca caugagcgug gucagggccc ggcgcaauga cagcggcacc      360

uaccucugug gggccaucuc ccuggccccc aaggcgcaga ucaaagagag ccugcgggca      420

gagcucaggg ugacagagag aagggcagaa gugcccacag cccaccccag ccccucaccc      480

aggccagccg gccaguucca aacccuggug guuggugucg ugggcggccu gcugggcagc      540

cuggugcugc uagucugggu ccuggccguc aucugcuccc gggccgcacg agggacaaua      600

ggagccaggc gcaccggcca gccccugaag gaggaccccu cagccgugcc uguguucucu      660

guggacuaug gggagcugga uuuccagugg cgagagaaga ccccggagcc ccccgugccc      720

ugugucccug agcagacgga guaugccacc auugucuuuc cuagcggaau gggcaccuca      780

ucccccgccc gcaggggcuc agccgacggc ccucggagug cccagccacu gaggccugag      840

gauggacacu gcucuuggcc ccucuga                                          867


<210>  13
<211>  450
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  PDCD1(1-149) CDS mRNA wild type

<400>  13
augcagaucc cacaggcgcc cuggccaguc gucugggcgg ugcuacaacu gggcuggcgg       60

ccaggauggu ucuuagacuc cccagacagg cccuggaacc cccccaccuu cuccccagcc      120

cugcucgugg ugaccgaagg ggacaacgcc accuucaccu gcagcuucuc caacacaucg      180

gagagcuucg ugcuaaacug guaccgcaug agccccagca accagacgga caagcuggcc      240

gcuuuccccg aggaccgcag ccagcccggc caggacugcc gcuuccgugu cacacaacug      300

cccaacgggc gugacuucca caugagcgug gucagggccc ggcgcaauga cagcggcacc      360

uaccucugug gggccaucuc ccuggccccc aaggcgcaga ucaaagagag ccugcgggca      420

gagcucaggg ugacagagag aagggcauga                                       450


<210>  14
<211>  660
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  IL12A CDS mRNA wild type

<400>  14
auguguccag cgcgcagccu ccuccuugug gcuacccugg uccuccugga ccaccucagu       60

uuggccagaa accuccccgu ggccacucca gacccaggaa uguucccaug ccuucaccac      120

ucccaaaacc ugcugagggc cgucagcaac augcuccaga aggccagaca aacucuagaa      180

uuuuacccuu gcacuucuga agagauugau caugaagaua ucacaaaaga uaaaaccagc      240

acaguggagg ccuguuuacc auuggaauua accaagaaug agaguugccu aaauuccaga      300

gagaccucuu ucauaacuaa ugggaguugc cuggccucca gaaagaccuc uuuuaugaug      360

gcccugugcc uuaguaguau uuaugaagac uugaagaugu accaggugga guucaagacc      420

augaaugcaa agcuucugau ggauccuaag aggcagaucu uucuagauca aaacaugcug      480

gcaguuauug augagcugau gcaggcccug aauuucaaca gugagacugu gccacaaaaa      540

uccucccuug aagaaccgga uuuuuauaaa acuaaaauca agcucugcau acuucuucau      600

gcuuucagaa uucgggcagu gacuauugau agagugauga gcuaucugaa ugcuuccuaa      660


<210>  15
<211>  657
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  IL12A(1-219) CDS mRNA wild type

<400>  15
auguguccag cgcgcagccu ccuccuugug gcuacccugg uccuccugga ccaccucagu       60

uuggccagaa accuccccgu ggccacucca gacccaggaa uguucccaug ccuucaccac      120

ucccaaaacc ugcugagggc cgucagcaac augcuccaga aggccagaca aacucuagaa      180

uuuuacccuu gcacuucuga agagauugau caugaagaua ucacaaaaga uaaaaccagc      240

acaguggagg ccuguuuacc auuggaauua accaagaaug agaguugccu aaauuccaga      300

gagaccucuu ucauaacuaa ugggaguugc cuggccucca gaaagaccuc uuuuaugaug      360

gcccugugcc uuaguaguau uuaugaagac uugaagaugu accaggugga guucaagacc      420

augaaugcaa agcuucugau ggauccuaag aggcagaucu uucuagauca aaacaugcug      480

gcaguuauug augagcugau gcaggcccug aauuucaaca gugagacugu gccacaaaaa      540

uccucccuug aagaaccgga uuuuuauaaa acuaaaauca agcucugcau acuucuucau      600

gcuuucagaa uucgggcagu gacuauugau agagugauga gcuaucugaa ugcuucc         657


<210>  16
<211>  594
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  IL12A(23-219) CDS mRNA wild type

<400>  16
agaaaccucc ccguggccac uccagaccca ggaauguucc caugccuuca ccacucccaa       60

aaccugcuga gggccgucag caacaugcuc cagaaggcca gacaaacucu agaauuuuac      120

ccuugcacuu cugaagagau ugaucaugaa gauaucacaa aagauaaaac cagcacagug      180

gaggccuguu uaccauugga auuaaccaag aaugagaguu gccuaaauuc cagagagacc      240

ucuuucauaa cuaaugggag uugccuggcc uccagaaaga ccucuuuuau gauggcccug      300

ugccuuagua guauuuauga agacuugaag auguaccagg uggaguucaa gaccaugaau      360

gcaaagcuuc ugauggaucc uaagaggcag aucuuucuag aucaaaacau gcuggcaguu      420

auugaugagc ugaugcaggc ccugaauuuc aacagugaga cugugccaca aaaauccucc      480

cuugaagaac cggauuuuua uaaaacuaaa aucaagcucu gcauacuucu ucaugcuuuc      540

agaauucggg cagugacuau ugauagagug augagcuauc ugaaugcuuc cuaa            594


<210>  17
<211>  987
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  IL12B CDS mRNA wild type

<400>  17
augugucacc agcaguuggu caucucuugg uuuucccugg uuuuucuggc aucuccccuc       60

guggccauau gggaacugaa gaaagauguu uaugucguag aauuggauug guauccggau      120

gccccuggag aaaugguggu ccucaccugu gacaccccug aagaagaugg uaucaccugg      180

accuuggacc agagcaguga ggucuuaggc ucuggcaaaa cccugaccau ccaagucaaa      240

gaguuuggag augcuggcca guacaccugu cacaaaggag gcgagguucu aagccauucg      300

cuccugcugc uucacaaaaa ggaagaugga auuuggucca cugauauuuu aaaggaccag      360

aaagaaccca aaaauaagac cuuucuaaga ugcgaggcca agaauuauuc uggacguuuc      420

accugcuggu ggcugacgac aaucaguacu gauuugacau ucagugucaa aagcagcaga      480

ggcucuucug acccccaagg ggugacgugc ggagcugcua cacucucugc agagagaguc      540

agaggggaca acaaggagua ugaguacuca guggagugcc aggaggacag ugccugccca      600

gcugcugagg agagucugcc cauugagguc augguggaug ccguucacaa gcucaaguau      660

gaaaacuaca ccagcagcuu cuucaucagg gacaucauca aaccugaccc acccaagaac      720

uugcagcuga agccauuaaa gaauucucgg cagguggagg ucagcuggga guacccugac      780

accuggagua cuccacauuc cuacuucucc cugacauucu gcguucaggu ccagggcaag      840

agcaagagag aaaagaaaga uagagucuuc acggacaaga ccucagccac ggucaucugc      900

cgcaaaaaug ccagcauuag cgugcgggcc caggaccgcu acuauagcuc aucuuggagc      960

gaaugggcau cugugcccug caguuag                                          987


<210>  18
<211>  984
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  IL12B(1-328) CDS mRNA wild type

<400>  18
augugucacc agcaguuggu caucucuugg uuuucccugg uuuuucuggc aucuccccuc       60

guggccauau gggaacugaa gaaagauguu uaugucguag aauuggauug guauccggau      120

gccccuggag aaaugguggu ccucaccugu gacaccccug aagaagaugg uaucaccugg      180

accuuggacc agagcaguga ggucuuaggc ucuggcaaaa cccugaccau ccaagucaaa      240

gaguuuggag augcuggcca guacaccugu cacaaaggag gcgagguucu aagccauucg      300

cuccugcugc uucacaaaaa ggaagaugga auuuggucca cugauauuuu aaaggaccag      360

aaagaaccca aaaauaagac cuuucuaaga ugcgaggcca agaauuauuc uggacguuuc      420

accugcuggu ggcugacgac aaucaguacu gauuugacau ucagugucaa aagcagcaga      480

ggcucuucug acccccaagg ggugacgugc ggagcugcua cacucucugc agagagaguc      540

agaggggaca acaaggagua ugaguacuca guggagugcc aggaggacag ugccugccca      600

gcugcugagg agagucugcc cauugagguc augguggaug ccguucacaa gcucaaguau      660

gaaaacuaca ccagcagcuu cuucaucagg gacaucauca aaccugaccc acccaagaac      720

uugcagcuga agccauuaaa gaauucucgg cagguggagg ucagcuggga guacccugac      780

accuggagua cuccacauuc cuacuucucc cugacauucu gcguucaggu ccagggcaag      840

agcaagagag aaaagaaaga uagagucuuc acggacaaga ccucagccac ggucaucugc      900

cgcaaaaaug ccagcauuag cgugcgggcc caggaccgcu acuauagcuc aucuuggagc      960

gaaugggcau cugugcccug cagu                                             984


<210>  19
<211>  921
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  IL12B(23-328) CDS mRNA wild type

<400>  19
auaugggaac ugaagaaaga uguuuauguc guagaauugg auugguaucc ggaugccccu       60

ggagaaaugg ugguccucac cugugacacc ccugaagaag augguaucac cuggaccuug      120

gaccagagca gugaggucuu aggcucuggc aaaacccuga ccauccaagu caaagaguuu      180

ggagaugcug gccaguacac cugucacaaa ggaggcgagg uucuaagcca uucgcuccug      240

cugcuucaca aaaaggaaga uggaauuugg uccacugaua uuuuaaagga ccagaaagaa      300

cccaaaaaua agaccuuucu aagaugcgag gccaagaauu auucuggacg uuucaccugc      360

ugguggcuga cgacaaucag uacugauuug acauucagug ucaaaagcag cagaggcucu      420

ucugaccccc aaggggugac gugcggagcu gcuacacucu cugcagagag agucagaggg      480

gacaacaagg aguaugagua cucaguggag ugccaggagg acagugccug cccagcugcu      540

gaggagaguc ugcccauuga ggucauggug gaugccguuc acaagcucaa guaugaaaac      600

uacaccagca gcuucuucau cagggacauc aucaaaccug acccacccaa gaacuugcag      660

cugaagccau uaaagaauuc ucggcaggug gaggucagcu gggaguaccc ugacaccugg      720

aguacuccac auuccuacuu cucccugaca uucugcguuc agguccaggg caagagcaag      780

agagaaaaga aagauagagu cuucacggac aagaccucag ccacggucau cugccgcaaa      840

aaugccagca uuagcgugcg ggcccaggac cgcuacuaua gcucaucuug gagcgaaugg      900

gcaucugugc ccugcaguua g                                                921


<210>  20
<211>  54
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Linker-sFvCC49-218 CDS mRNA wild type

<400>  20
ggcaguacuu cgggcagugg uaagccuggu aguggugagg guaguacuaa gggu             54


<210>  21
<211>  1632
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  IL12 CDS mRNA wild type

<400>  21
augugucacc agcaguuggu caucucuugg uuuucccugg uuuuucuggc aucuccccuc       60

guggccauau gggaacugaa gaaagauguu uaugucguag aauuggauug guauccggau      120

gccccuggag aaaugguggu ccucaccugu gacaccccug aagaagaugg uaucaccugg      180

accuuggacc agagcaguga ggucuuaggc ucuggcaaaa cccugaccau ccaagucaaa      240

gaguuuggag augcuggcca guacaccugu cacaaaggag gcgagguucu aagccauucg      300

cuccugcugc uucacaaaaa ggaagaugga auuuggucca cugauauuuu aaaggaccag      360

aaagaaccca aaaauaagac cuuucuaaga ugcgaggcca agaauuauuc uggacguuuc      420

accugcuggu ggcugacgac aaucaguacu gauuugacau ucagugucaa aagcagcaga      480

ggcucuucug acccccaagg ggugacgugc ggagcugcua cacucucugc agagagaguc      540

agaggggaca acaaggagua ugaguacuca guggagugcc aggaggacag ugccugccca      600

gcugcugagg agagucugcc cauugagguc augguggaug ccguucacaa gcucaaguau      660

gaaaacuaca ccagcagcuu cuucaucagg gacaucauca aaccugaccc acccaagaac      720

uugcagcuga agccauuaaa gaauucucgg cagguggagg ucagcuggga guacccugac      780

accuggagua cuccacauuc cuacuucucc cugacauucu gcguucaggu ccagggcaag      840

agcaagagag aaaagaaaga uagagucuuc acggacaaga ccucagccac ggucaucugc      900

cgcaaaaaug ccagcauuag cgugcgggcc caggaccgcu acuauagcuc aucuuggagc      960

gaaugggcau cugugcccug caguggcagu acuucgggca gugguaagcc ugguaguggu     1020

gaggguagua cuaaggguag aaaccucccc guggccacuc cagacccagg aauguuccca     1080

ugccuucacc acucccaaaa ccugcugagg gccgucagca acaugcucca gaaggccaga     1140

caaacucuag aauuuuaccc uugcacuucu gaagagauug aucaugaaga uaucacaaaa     1200

gauaaaacca gcacagugga ggccuguuua ccauuggaau uaaccaagaa ugagaguugc     1260

cuaaauucca gagagaccuc uuucauaacu aaugggaguu gccuggccuc cagaaagacc     1320

ucuuuuauga uggcccugug ccuuaguagu auuuaugaag acuugaagau guaccaggug     1380

gaguucaaga ccaugaaugc aaagcuucug auggauccua agaggcagau cuuucuagau     1440

caaaacaugc uggcaguuau ugaugagcug augcaggccc ugaauuucaa cagugagacu     1500

gugccacaaa aauccucccu ugaagaaccg gauuuuuaua aaacuaaaau caagcucugc     1560

auacuucuuc augcuuucag aauucgggca gugacuauug auagagugau gagcuaucug     1620

aaugcuuccu aa                                                         1632


<210>  22
<211>  786
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  CD40LG CDS mRNA wild type

<400>  22
augaucgaaa cauacaacca aacuucuccc cgaucugcgg ccacuggacu gcccaucagc       60

augaaaauuu uuauguauuu acuuacuguu uuucuuauca cccagaugau ugggucagca      120

cuuuuugcug uguaucuuca uagaagguug gacaagauag aagaugaaag gaaucuucau      180

gaagauuuug uauucaugaa aacgauacag agaugcaaca caggagaaag auccuuaucc      240

uuacugaacu gugaggagau uaaaagccag uuugaaggcu uugugaagga uauaauguua      300

aacaaagagg agacgaagaa agaaaacagc uuugaaaugc aaaaagguga ucagaauccu      360

caaauugcgg cacaugucau aagugaggcc agcaguaaaa caacaucugu guuacagugg      420

gcugaaaaag gauacuacac caugagcaac aacuugguaa cccuggaaaa ugggaaacag      480

cugaccguua aaagacaagg acucuauuau aucuaugccc aagucaccuu cuguuccaau      540

cgggaagcuu cgagucaagc uccauuuaua gccagccucu gccuaaaguc ccccgguaga      600

uucgagagaa ucuuacucag agcugcaaau acccacaguu ccgccaaacc uugcgggcaa      660

caauccauuc acuugggagg aguauuugaa uugcaaccag gugcuucggu guuugucaau      720

gugacugauc caagccaagu gagccauggc acuggcuuca cguccuuugg cuuacucaaa      780

cucuga                                                                 786


<210>  23
<211>  867
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  PDCD1 CDS mRNA opt1

<400>  23
augcagaucc cccaggcccc guggcccgug gucugggccg ugcugcagcu cggcuggcgc       60

cccggguggu uccuggacag ccccgaccgg ccguggaacc cgcccaccuu cucccccgcg      120

cugcucgugg ucaccgaggg cgacaacgcc acguucacgu gcagcuucuc caacaccagc      180

gaguccuucg ugcugaacug guaccgcaug agccccucca accagaccga caagcuggcc      240

gccuuccccg aggaccggag ccagcccggg caggacugcc gcuuccgggu gacccagcuc      300

cccaacggcc gcgacuucca cauguccguc gugcgggccc gccggaacga cagcgggacc      360

uaccugugcg gcgcgaucuc ccuggccccg aaggcccaga ucaaggagag ccuccgcgcc      420

gagcugcggg ugaccgagcg ccgggcggag guccccaccg cccaccccuc ccccagcccg      480

cgccccgccg gccaguucca gacgcuggug gugggggucg ugggcgggcu ccugggcucc      540

cuggugcucc uggucugggu gcuggccgug aucugcagcc gggccgcgcg cgggaccauc      600

ggcgcccggc gcaccggcca gccccucaag gaggaccccu ccgccguccc gguguucagc      660

guggacuacg gggagcugga cuuccagugg cgggagaaga cccccgagcc gcccgucccc      720

ugcgugcccg agcagacgga guacgccacc aucguguucc ccuccggcau ggggaccagc      780

agccccgccc gccggggcuc cgcggacggc ccgcgcagcg cccagccccu gcgccccgag      840

gacgggcacu gcuccuggcc gcucuga                                          867


<210>  24
<211>  450
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  PDCD1(1-149) CDS mRNA opt1

<400>  24
augcagaucc cccaggcccc guggcccgug gucugggccg ugcugcagcu cggcuggcgc       60

cccggguggu uccuggacag ccccgaccgg ccguggaacc cgcccaccuu cucccccgcg      120

cugcucgugg ucaccgaggg cgacaacgcc acguucacgu gcagcuucuc caacaccagc      180

gaguccuucg ugcugaacug guaccgcaug agccccucca accagaccga caagcuggcc      240

gccuuccccg aggaccggag ccagcccggg caggacugcc gcuuccgggu gacccagcuc      300

cccaacggcc gcgacuucca cauguccguc gugcgggccc gccggaacga cagcgggacc      360

uaccugugcg gcgcgaucuc ccuggccccg aaggcccaga ucaaggagag ccuccgcgcc      420

gagcugcggg ugaccgagcg ccgggcguga                                       450


<210>  25
<211>  660
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  IL12A CDS mRNA opt1

<400>  25
augugccccg cccgcagccu gcuccuggug gccacccugg uccuccugga ccaccugucc       60

cucgcgcgga accugccggu ggccaccccc gaccccggca uguuccccug ccugcaccac      120

agccagaacc uccugcgcgc cguguccaac augcugcaga aggcccggca gacgcucgag      180

uucuacccgu gcaccagcga ggagaucgac cacgaggaca ucaccaagga caagaccucc      240

acggucgagg ccugccugcc ccuggagcuc accaagaacg agagcugccu gaacucccgc      300

gagaccagcu ucaucaccaa cggguccugc cuggcgagcc ggaagacguc cuucaugaug      360

gcccucugcc ugagcuccau cuacgaggac cugaagaugu accaggugga guucaagacc      420

augaacgcca agcuccugau ggaccccaag cgccagaucu uccuggacca gaacaugcuc      480

gccgugaucg acgagcugau gcaggcgcug aacuucaaca gcgagaccgu cccccagaag      540

uccagccucg aggagccgga cuucuacaag accaagauca agcugugcau ccugcuccac      600

gccuuccgga uccgcgccgu gacgaucgac cgggugaugu ccuaccugaa cgccagcuga      660


<210>  26
<211>  657
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  IL12A(1-219) CDS mRNA opt1

<400>  26
augugccccg cccgcagccu gcuccuggug gccacccugg uccuccugga ccaccugucc       60

cucgcgcgga accugccggu ggccaccccc gaccccggca uguuccccug ccugcaccac      120

agccagaacc uccugcgcgc cguguccaac augcugcaga aggcccggca gacgcucgag      180

uucuacccgu gcaccagcga ggagaucgac cacgaggaca ucaccaagga caagaccucc      240

acggucgagg ccugccugcc ccuggagcuc accaagaacg agagcugccu gaacucccgc      300

gagaccagcu ucaucaccaa cggguccugc cuggcgagcc ggaagacguc cuucaugaug      360

gcccucugcc ugagcuccau cuacgaggac cugaagaugu accaggugga guucaagacc      420

augaacgcca agcuccugau ggaccccaag cgccagaucu uccuggacca gaacaugcuc      480

gccgugaucg acgagcugau gcaggcgcug aacuucaaca gcgagaccgu cccccagaag      540

uccagccucg aggagccgga cuucuacaag accaagauca agcugugcau ccugcuccac      600

gccuuccgga uccgcgccgu gacgaucgac cgggugaugu ccuaccugaa cgccagc         657


<210>  27
<211>  594
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  IL12A(23-219) CDS mRNA opt1

<400>  27
cggaaccugc cgguggccac ccccgacccc ggcauguucc ccugccugca ccacagccag       60

aaccuccugc gcgccguguc caacaugcug cagaaggccc ggcagacgcu cgaguucuac      120

ccgugcacca gcgaggagau cgaccacgag gacaucacca aggacaagac cuccacgguc      180

gaggccugcc ugccccugga gcucaccaag aacgagagcu gccugaacuc ccgcgagacc      240

agcuucauca ccaacggguc cugccuggcg agccggaaga cguccuucau gauggcccuc      300

ugccugagcu ccaucuacga ggaccugaag auguaccagg uggaguucaa gaccaugaac      360

gccaagcucc ugauggaccc caagcgccag aucuuccugg accagaacau gcucgccgug      420

aucgacgagc ugaugcaggc gcugaacuuc aacagcgaga ccguccccca gaaguccagc      480

cucgaggagc cggacuucua caagaccaag aucaagcugu gcauccugcu ccacgccuuc      540

cggauccgcg ccgugacgau cgaccgggug auguccuacc ugaacgccag cuga            594


<210>  28
<211>  987
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  IL12B CDS mRNA opt1

<400>  28
augugccacc agcagcuggu gaucagcugg uucucccucg ucuuccuggc cagcccccug       60

guggccaucu gggagcucaa gaaggacgug uacgucgugg agcuggacug guacccggac      120

gcgcccggcg agaugguggu ccugaccugc gacacccccg aggaggacgg gaucacgugg      180

acccucgacc aguccagcga ggugcugggc uccgggaaga cccugaccau ccaggugaag      240

gaguucggcg acgccgggca guacacgugc cacaagggcg gcgagguccu cagccacucc      300

cugcugcucc ugcacaagaa ggaggacggg aucuggagca ccgacauccu gaaggaccag      360

aaggagccca agaacaagac cuuccuccgc ugcgaggcca agaacuacuc cggccgguuc      420

acgugcuggu ggcugaccac caucagcacc gaccugaccu ucuccgucaa gagcucccgc      480

gggagcuccg acccgcaggg cgugacgugc ggggccgcca cccucagcgc ggagcgggug      540

cgcggcgaca acaaggagua cgaguacucc guggagugcc aggaggacag cgccugcccc      600

gccgccgagg agucccugcc caucgaggug auggucgacg cggugcacaa gcugaaguac      660

gagaacuaca ccagcagcuu cuucauccgg gacaucauca agcccgaccc gcccaagaac      720

cuccagcuga agccccugaa gaacucccgc cagguggagg ucagcuggga guaccccgac      780

accuggucca cgccgcacag cuacuucucc cucaccuucu gcguccaggu gcagggcaag      840

agcaagcggg agaagaagga ccgcguguuc accgacaaga ccuccgccac ggugaucugc      900

cggaagaacg ccagcaucuc cgugcgcgcc caggaccggu acuacagcuc cagcuggucc      960

gagugggcca gcguccccug cuccuga                                          987


<210>  29
<211>  984
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  IL12B(1-328) CDS mRNA opt1

<400>  29
augugccacc agcagcuggu gaucagcugg uucucccucg ucuuccuggc cagcccccug       60

guggccaucu gggagcucaa gaaggacgug uacgucgugg agcuggacug guacccggac      120

gcgcccggcg agaugguggu ccugaccugc gacacccccg aggaggacgg gaucacgugg      180

acccucgacc aguccagcga ggugcugggc uccgggaaga cccugaccau ccaggugaag      240

gaguucggcg acgccgggca guacacgugc cacaagggcg gcgagguccu cagccacucc      300

cugcugcucc ugcacaagaa ggaggacggg aucuggagca ccgacauccu gaaggaccag      360

aaggagccca agaacaagac cuuccuccgc ugcgaggcca agaacuacuc cggccgguuc      420

acgugcuggu ggcugaccac caucagcacc gaccugaccu ucuccgucaa gagcucccgc      480

gggagcuccg acccgcaggg cgugacgugc ggggccgcca cccucagcgc ggagcgggug      540

cgcggcgaca acaaggagua cgaguacucc guggagugcc aggaggacag cgccugcccc      600

gccgccgagg agucccugcc caucgaggug auggucgacg cggugcacaa gcugaaguac      660

gagaacuaca ccagcagcuu cuucauccgg gacaucauca agcccgaccc gcccaagaac      720

cuccagcuga agccccugaa gaacucccgc cagguggagg ucagcuggga guaccccgac      780

accuggucca cgccgcacag cuacuucucc cucaccuucu gcguccaggu gcagggcaag      840

agcaagcggg agaagaagga ccgcguguuc accgacaaga ccuccgccac ggugaucugc      900

cggaagaacg ccagcaucuc cgugcgcgcc caggaccggu acuacagcuc cagcuggucc      960

gagugggcca gcguccccug cucc                                             984


<210>  30
<211>  921
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  IL12B(23-328) CDS mRNA opt1

<400>  30
aucugggagc ucaagaagga cguguacguc guggagcugg acugguaccc ggacgcgccc       60

ggcgagaugg ugguccugac cugcgacacc cccgaggagg acgggaucac guggacccuc      120

gaccagucca gcgaggugcu gggcuccggg aagacccuga ccauccaggu gaaggaguuc      180

ggcgacgccg ggcaguacac gugccacaag ggcggcgagg uccucagcca cucccugcug      240

cuccugcaca agaaggagga cgggaucugg agcaccgaca uccugaagga ccagaaggag      300

cccaagaaca agaccuuccu ccgcugcgag gccaagaacu acuccggccg guucacgugc      360

ugguggcuga ccaccaucag caccgaccug accuucuccg ucaagagcuc ccgcgggagc      420

uccgacccgc agggcgugac gugcggggcc gccacccuca gcgcggagcg ggugcgcggc      480

gacaacaagg aguacgagua cuccguggag ugccaggagg acagcgccug ccccgccgcc      540

gaggaguccc ugcccaucga ggugaugguc gacgcggugc acaagcugaa guacgagaac      600

uacaccagca gcuucuucau ccgggacauc aucaagcccg acccgcccaa gaaccuccag      660

cugaagcccc ugaagaacuc ccgccaggug gaggucagcu gggaguaccc cgacaccugg      720

uccacgccgc acagcuacuu cucccucacc uucugcgucc aggugcaggg caagagcaag      780

cgggagaaga aggaccgcgu guucaccgac aagaccuccg ccacggugau cugccggaag      840

aacgccagca ucuccgugcg cgcccaggac cgguacuaca gcuccagcug guccgagugg      900

gccagcgucc ccugcuccug a                                                921


<210>  31
<211>  54
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Linker-sFvCC49-218 CDS mRNA opt1

<400>  31
ggcagcaccu ccgggagcgg caagcccggg uccggcgagg ggagcaccaa gggc             54


<210>  32
<211>  1632
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  IL12 CDS mRNA opt1

<400>  32
augugccacc agcagcuggu gaucagcugg uucucccucg ucuuccuggc cagcccccug       60

guggccaucu gggagcucaa gaaggacgug uacgucgugg agcuggacug guacccggac      120

gcgcccggcg agaugguggu ccugaccugc gacacccccg aggaggacgg gaucacgugg      180

acccucgacc aguccagcga ggugcugggc uccgggaaga cccugaccau ccaggugaag      240

gaguucggcg acgccgggca guacacgugc cacaagggcg gcgagguccu cagccacucc      300

cugcugcucc ugcacaagaa ggaggacggg aucuggagca ccgacauccu gaaggaccag      360

aaggagccca agaacaagac cuuccuccgc ugcgaggcca agaacuacuc cggccgguuc      420

acgugcuggu ggcugaccac caucagcacc gaccugaccu ucuccgucaa gagcucccgc      480

gggagcuccg acccgcaggg cgugacgugc ggggccgcca cccucagcgc ggagcgggug      540

cgcggcgaca acaaggagua cgaguacucc guggagugcc aggaggacag cgccugcccc      600

gccgccgagg agucccugcc caucgaggug auggucgacg cggugcacaa gcugaaguac      660

gagaacuaca ccagcagcuu cuucauccgg gacaucauca agcccgaccc gcccaagaac      720

cuccagcuga agccccugaa gaacucccgc cagguggagg ucagcuggga guaccccgac      780

accuggucca cgccgcacag cuacuucucc cucaccuucu gcguccaggu gcagggcaag      840

agcaagcggg agaagaagga ccgcguguuc accgacaaga ccuccgccac ggugaucugc      900

cggaagaacg ccagcaucuc cgugcgcgcc caggaccggu acuacagcuc cagcuggucc      960

gagugggcca gcguccccug cuccggcagc accuccggga gcggcaagcc cggguccggc     1020

gaggggagca ccaagggccg gaaccugccg guggccaccc ccgaccccgg cauguucccc     1080

ugccugcacc acagccagaa ccuccugcgc gccgugucca acaugcugca gaaggcccgg     1140

cagacgcucg aguucuaccc gugcaccagc gaggagaucg accacgagga caucaccaag     1200

gacaagaccu ccacggucga ggccugccug ccccuggagc ucaccaagaa cgagagcugc     1260

cugaacuccc gcgagaccag cuucaucacc aacggguccu gccuggcgag ccggaagacg     1320

uccuucauga uggcccucug ccugagcucc aucuacgagg accugaagau guaccaggug     1380

gaguucaaga ccaugaacgc caagcuccug auggacccca agcgccagau cuuccuggac     1440

cagaacaugc ucgccgugau cgacgagcug augcaggcgc ugaacuucaa cagcgagacc     1500

gucccccaga aguccagccu cgaggagccg gacuucuaca agaccaagau caagcugugc     1560

auccugcucc acgccuuccg gauccgcgcc gugacgaucg accgggugau guccuaccug     1620

aacgccagcu ga                                                         1632


<210>  33
<211>  786
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  CD40LG CDS mRNA opt1

<400>  33
augaucgaga ccuacaacca gaccagcccc cgcuccgccg ccacgggccu gccgaucagc       60

augaagaucu ucauguaccu ccugaccgug uuccugauca cccagaugau cggguccgcg      120

cuguucgccg ucuaccugca ccggcgccug gacaagaucg aggacgagcg gaaccuccac      180

gaggacuucg uguucaugaa gaccauccag cgcugcaaca cgggcgagcg gagccugucc      240

cugcucaacu gcgaggagau caagagccag uucgaggggu ucgugaagga caucaugcug      300

aacaaggagg agaccaagaa ggagaacucc uucgagaugc agaagggcga ccagaacccc      360

cagaucgccg cccacgucau cagcgaggcc uccagcaaga ccaccuccgu gcugcagugg      420

gcggagaagg gguacuacac gaugagcaac aaccucguga cccuggagaa cggcaagcag      480

cugaccguca agcgccaggg ccucuacuac aucuacgccc aggugaccuu cugcuccaac      540

cgggaggcca gcucccaggc ccccuucauc gcgagccugu gccugaaguc ccccgggcgc      600

uucgagcgga uccuccugcg cgccgccaac acgcacagcu ccgccaagcc gugcggccag      660

cagagcaucc accucggggg cguguucgag cuccagcccg gggccagcgu cuucgugaac      720

gugaccgacc ccucccaggu cagccacggc accggcuuca ccuccuucgg gcugcugaag      780

cucuga                                                                 786


<210>  34
<211>  867
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  PDCD1 CDS mRNA opt2

<400>  34
augcagaucc cccaggcccc cuggcccguc gucugggccg uccuccagcu cggcuggcgc       60

cccggcuggu uccucgacuc ccccgaccgc cccuggaacc cccccaccuu cucccccgcc      120

cuccucgucg ucaccgaggg cgacaacgcc accuucaccu guuccuucuc caacaccucc      180

gaguccuucg uccucaacug guaccgcaug ucccccucca accagaccga caagcucgcc      240

gccuuccccg aggaccgcuc ccagcccggc caggacugcc gcuuccgcgu cacccagcuc      300

cccaacggcc gcgacuucca cauguccguc guccgcgccc gccgcaacga cuccggcacc      360

uaccucugcg gcgccaucuc ccucgccccc aaggcccaga ucaaggaguc ccuccgcgcc      420

gagcuccgcg ucaccgagcg ccgcgccgag guccccaccg cccaccccuc ccccuccccc      480

cgccccgccg gccaguucca gacccucguc gucggcgucg ucggcggccu ccucggcucc      540

cucguccucc ucgucugggu ccucgccguc aucugcuccc gcgccgcccg cggcaccauc      600

ggcgcccgcc gcaccggcca gccccucaag gaggaccccu ccgccguccc cgucuucucc      660

gucgacuacg gcgagcucga cuuccagugg cgcgagaaga cccccgagcc ccccgucccc      720

ugcguccccg agcagaccga guacgccacc aucgucuucc ccuccggcau gggcaccucc      780

ucccccgccc gccgcggcuc cgccgacggc ccccgcuccg cccagccccu ccgccccgag      840

gacggccacu gcuccuggcc ccucuga                                          867


<210>  35
<211>  450
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  PDCD1(1-149) CDS mRNA opt2

<400>  35
augcagaucc cccaggcccc cuggcccguc gucugggccg uccuccagcu cggcuggcgc       60

cccggcuggu uccucgacuc ccccgaccgc cccuggaacc cccccaccuu cucccccgcc      120

cuccucgucg ucaccgaggg cgacaacgcc accuucaccu guuccuucuc caacaccucc      180

gaguccuucg uccucaacug guaccgcaug ucccccucca accagaccga caagcucgcc      240

gccuuccccg aggaccgcuc ccagcccggc caggacugcc gcuuccgcgu cacccagcuc      300

cccaacggcc gcgacuucca cauguccguc guccgcgccc gccgcaacga cuccggcacc      360

uaccucugcg gcgccaucuc ccucgccccc aaggcccaga ucaaggaguc ccuccgcgcc      420

gagcuccgcg ucaccgagcg ccgcgccuga                                       450


<210>  36
<211>  660
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  IL12A CDS mRNA opt2

<400>  36
augugccccg cccgcucccu ccuccucguc gccacccucg uccuccucga ccaccucucc       60

cucgcccgca accuccccgu cgccaccccc gaccccggca uguuccccug ccuccaccac      120

ucccagaacc uccuccgcgc cgucuccaac augcuccaga aggcccgcca gacccucgag      180

uucuaccccu gcaccuccga ggagaucgac cacgaggaca ucaccaagga caagaccucc      240

accgucgagg ccugccuccc ccucgagcuc accaagaacg aguccugccu caacucccgc      300

gagaccuccu ucaucaccaa cggcuccugc cucgccuccc gcaagaccuc cuucaugaug      360

gcccucugcc ucuccuccau cuacgaggac cucaagaugu accaggucga guucaagacc      420

augaacgcca agcuccucau ggaccccaag cgccagaucu uccucgacca gaacaugcuc      480

gccgucaucg acgagcucau gcaggcccuc aacuucaacu ccgagaccgu cccccagaag      540

uccucccucg aggagcccga cuucuacaag accaagauca agcucugcau ccuccuccac      600

gccuuccgca uccgcgccgu caccaucgac cgcgucaugu ccuaccucaa cgccuccuga      660


<210>  37
<211>  657
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  IL12A(1-219) CDS mRNA opt2

<400>  37
augugccccg cccgcucccu ccuccucguc gccacccucg uccuccucga ccaccucucc       60

cucgcccgca accuccccgu cgccaccccc gaccccggca uguuccccug ccuccaccac      120

ucccagaacc uccuccgcgc cgucuccaac augcuccaga aggcccgcca gacccucgag      180

uucuaccccu gcaccuccga ggagaucgac cacgaggaca ucaccaagga caagaccucc      240

accgucgagg ccugccuccc ccucgagcuc accaagaacg aguccugccu caacucccgc      300

gagaccuccu ucaucaccaa cggcuccugc cucgccuccc gcaagaccuc cuucaugaug      360

gcccucugcc ucuccuccau cuacgaggac cucaagaugu accaggucga guucaagacc      420

augaacgcca agcuccucau ggaccccaag cgccagaucu uccucgacca gaacaugcuc      480

gccgucaucg acgagcucau gcaggcccuc aacuucaacu ccgagaccgu cccccagaag      540

uccucccucg aggagcccga cuucuacaag accaagauca agcucugcau ccuccuccac      600

gccuuccgca uccgcgccgu caccaucgac cgcgucaugu ccuaccucaa cgccucc         657


<210>  38
<211>  594
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  IL12A(23-219) CDS mRNA opt2

<400>  38
cgcaaccucc ccgucgccac ccccgacccc ggcauguucc ccugccucca ccacucccag       60

aaccuccucc gcgccgucuc caacaugcuc cagaaggccc gccagacccu cgaguucuac      120

cccugcaccu ccgaggagau cgaccacgag gacaucacca aggacaagac cuccaccguc      180

gaggccugcc ucccccucga gcucaccaag aacgaguccu gccucaacuc ccgcgagacc      240

uccuucauca ccaacggcuc cugccucgcc ucccgcaaga ccuccuucau gauggcccuc      300

ugccucuccu ccaucuacga ggaccucaag auguaccagg ucgaguucaa gaccaugaac      360

gccaagcucc ucauggaccc caagcgccag aucuuccucg accagaacau gcucgccguc      420

aucgacgagc ucaugcaggc ccucaacuuc aacuccgaga ccguccccca gaaguccucc      480

cucgaggagc ccgacuucua caagaccaag aucaagcucu gcauccuccu ccacgccuuc      540

cgcauccgcg ccgucaccau cgaccgcguc auguccuacc ucaacgccuc cuga            594


<210>  39
<211>  987
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  IL12B CDS mRNA opt2

<400>  39
augugccacc agcagcucgu caucuccugg uucucccucg ucuuccucgc cuccccccuc       60

gucgccaucu gggagcucaa gaaggacguc uacgucgucg agcucgacug guaccccgac      120

gcccccggcg agauggucgu ccucaccugu gacacccccg aggaggacgg caucaccugg      180

acccucgacc aguccuccga gguccucggc uccggcaaga cccucaccau ccaggucaag      240

gaguucggcg acgccggcca guacaccugu cacaagggcg gcgagguccu cucccacucc      300

cuccuccucc uccacaagaa ggaggacggc aucuggucca ccgacauccu caaggaccag      360

aaggagccca agaacaagac cuuccuccgc ugcgaggcca agaacuacuc cggccgcuuc      420

accuguuggu ggcucaccac caucuccacc gaccucaccu ucuccgucaa guccucccgc      480

ggcuccuccg acccccaggg cgucaccugu ggcgccgcca cccucuccgc cgagcgcguc      540

cgcggcgaca acaaggagua cgaguacucc gucgagugcc aggaggacuc cgccugcccc      600

gccgccgagg agucccuccc caucgagguc auggucgacg ccguccacaa gcucaaguac      660

gagaacuaca ccuccuccuu cuucauccgc gacaucauca agcccgaccc ccccaagaac      720

cuccagcuca agccccucaa gaacucccgc caggucgagg ucuccuggga guaccccgac      780

accuggucca ccccccacuc cuacuucucc cucaccuucu gcguccaggu ccagggcaag      840

uccaagcgcg agaagaagga ccgcgucuuc accgacaaga ccuccgccac cgucaucugc      900

cgcaagaacg ccuccaucuc cguccgcgcc caggaccgcu acuacuccuc cuccuggucc      960

gagugggccu ccguccccug cuccuga                                          987


<210>  40
<211>  984
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  IL12B(1-328) CDS mRNA opt2

<400>  40
augugccacc agcagcucgu caucuccugg uucucccucg ucuuccucgc cuccccccuc       60

gucgccaucu gggagcucaa gaaggacguc uacgucgucg agcucgacug guaccccgac      120

gcccccggcg agauggucgu ccucaccugu gacacccccg aggaggacgg caucaccugg      180

acccucgacc aguccuccga gguccucggc uccggcaaga cccucaccau ccaggucaag      240

gaguucggcg acgccggcca guacaccugu cacaagggcg gcgagguccu cucccacucc      300

cuccuccucc uccacaagaa ggaggacggc aucuggucca ccgacauccu caaggaccag      360

aaggagccca agaacaagac cuuccuccgc ugcgaggcca agaacuacuc cggccgcuuc      420

accuguuggu ggcucaccac caucuccacc gaccucaccu ucuccgucaa guccucccgc      480

ggcuccuccg acccccaggg cgucaccugu ggcgccgcca cccucuccgc cgagcgcguc      540

cgcggcgaca acaaggagua cgaguacucc gucgagugcc aggaggacuc cgccugcccc      600

gccgccgagg agucccuccc caucgagguc auggucgacg ccguccacaa gcucaaguac      660

gagaacuaca ccuccuccuu cuucauccgc gacaucauca agcccgaccc ccccaagaac      720

cuccagcuca agccccucaa gaacucccgc caggucgagg ucuccuggga guaccccgac      780

accuggucca ccccccacuc cuacuucucc cucaccuucu gcguccaggu ccagggcaag      840

uccaagcgcg agaagaagga ccgcgucuuc accgacaaga ccuccgccac cgucaucugc      900

cgcaagaacg ccuccaucuc cguccgcgcc caggaccgcu acuacuccuc cuccuggucc      960

gagugggccu ccguccccug cucc                                             984


<210>  41
<211>  921
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  IL12B(23-328) CDS mRNA opt2

<400>  41
aucugggagc ucaagaagga cgucuacguc gucgagcucg acugguaccc cgacgccccc       60

ggcgagaugg ucguccucac cugugacacc cccgaggagg acggcaucac cuggacccuc      120

gaccaguccu ccgagguccu cggcuccggc aagacccuca ccauccaggu caaggaguuc      180

ggcgacgccg gccaguacac cugucacaag ggcggcgagg uccucuccca cucccuccuc      240

cuccuccaca agaaggagga cggcaucugg uccaccgaca uccucaagga ccagaaggag      300

cccaagaaca agaccuuccu ccgcugcgag gccaagaacu acuccggccg cuucaccugu      360

ugguggcuca ccaccaucuc caccgaccuc accuucuccg ucaaguccuc ccgcggcucc      420

uccgaccccc agggcgucac cuguggcgcc gccacccucu ccgccgagcg cguccgcggc      480

gacaacaagg aguacgagua cuccgucgag ugccaggagg acuccgccug ccccgccgcc      540

gaggaguccc uccccaucga ggucaugguc gacgccgucc acaagcucaa guacgagaac      600

uacaccuccu ccuucuucau ccgcgacauc aucaagcccg acccccccaa gaaccuccag      660

cucaagcccc ucaagaacuc ccgccagguc gaggucuccu gggaguaccc cgacaccugg      720

uccacccccc acuccuacuu cucccucacc uucugcgucc agguccaggg caaguccaag      780

cgcgagaaga aggaccgcgu cuucaccgac aagaccuccg ccaccgucau cugccgcaag      840

aacgccucca ucuccguccg cgcccaggac cgcuacuacu ccuccuccug guccgagugg      900

gccuccgucc ccugcuccug a                                                921


<210>  42
<211>  54
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Linker-sFvCC49-218 CDS mRNA opt2

<400>  42
ggcuccaccu ccggcuccgg caagcccggc uccggcgagg gcuccaccaa gggc             54


<210>  43
<211>  1632
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  IL12 CDS mRNA opt2

<400>  43
augugccacc agcagcucgu caucuccugg uucucccucg ucuuccucgc cuccccccuc       60

gucgccaucu gggagcucaa gaaggacguc uacgucgucg agcucgacug guaccccgac      120

gcccccggcg agauggucgu ccucaccugu gacacccccg aggaggacgg caucaccugg      180

acccucgacc aguccuccga gguccucggc uccggcaaga cccucaccau ccaggucaag      240

gaguucggcg acgccggcca guacaccugu cacaagggcg gcgagguccu cucccacucc      300

cuccuccucc uccacaagaa ggaggacggc aucuggucca ccgacauccu caaggaccag      360

aaggagccca agaacaagac cuuccuccgc ugcgaggcca agaacuacuc cggccgcuuc      420

accuguuggu ggcucaccac caucuccacc gaccucaccu ucuccgucaa guccucccgc      480

ggcuccuccg acccccaggg cgucaccugu ggcgccgcca cccucuccgc cgagcgcguc      540

cgcggcgaca acaaggagua cgaguacucc gucgagugcc aggaggacuc cgccugcccc      600

gccgccgagg agucccuccc caucgagguc auggucgacg ccguccacaa gcucaaguac      660

gagaacuaca ccuccuccuu cuucauccgc gacaucauca agcccgaccc ccccaagaac      720

cuccagcuca agccccucaa gaacucccgc caggucgagg ucuccuggga guaccccgac      780

accuggucca ccccccacuc cuacuucucc cucaccuucu gcguccaggu ccagggcaag      840

uccaagcgcg agaagaagga ccgcgucuuc accgacaaga ccuccgccac cgucaucugc      900

cgcaagaacg ccuccaucuc cguccgcgcc caggaccgcu acuacuccuc cuccuggucc      960

gagugggccu ccguccccug cuccggcucc accuccggcu ccggcaagcc cggcuccggc     1020

gagggcucca ccaagggccg caaccucccc gucgccaccc ccgaccccgg cauguucccc     1080

ugccuccacc acucccagaa ccuccuccgc gccgucucca acaugcucca gaaggcccgc     1140

cagacccucg aguucuaccc cugcaccucc gaggagaucg accacgagga caucaccaag     1200

gacaagaccu ccaccgucga ggccugccuc ccccucgagc ucaccaagaa cgaguccugc     1260

cucaacuccc gcgagaccuc cuucaucacc aacggcuccu gccucgccuc ccgcaagacc     1320

uccuucauga uggcccucug ccucuccucc aucuacgagg accucaagau guaccagguc     1380

gaguucaaga ccaugaacgc caagcuccuc auggacccca agcgccagau cuuccucgac     1440

cagaacaugc ucgccgucau cgacgagcuc augcaggccc ucaacuucaa cuccgagacc     1500

gucccccaga aguccucccu cgaggagccc gacuucuaca agaccaagau caagcucugc     1560

auccuccucc acgccuuccg cauccgcgcc gucaccaucg accgcgucau guccuaccuc     1620

aacgccuccu ga                                                         1632


<210>  44
<211>  786
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  CD40LG CDS mRNA opt2

<400>  44
augaucgaga ccuacaacca gaccuccccc cgcuccgccg ccaccggccu ccccaucucc       60

augaagaucu ucauguaccu ccucaccguc uuccucauca cccagaugau cggcuccgcc      120

cucuucgccg ucuaccucca ccgccgccuc gacaagaucg aggacgagcg caaccuccac      180

gaggacuucg ucuucaugaa gaccauccag cgcugcaaca ccggcgagcg cucccucucc      240

cuccucaacu gcgaggagau caagucccag uucgagggcu ucgucaagga caucaugcuc      300

aacaaggagg agaccaagaa ggagaacucc uucgagaugc agaagggcga ccagaacccc      360

cagaucgccg cccacgucau cuccgaggcc uccuccaaga ccaccuccgu ccuccagugg      420

gccgagaagg gcuacuacac cauguccaac aaccucguca cccucgagaa cggcaagcag      480

cucaccguca agcgccaggg ccucuacuac aucuacgccc aggucaccuu cugcuccaac      540

cgcgaggccu ccucccaggc ccccuucauc gccucccucu gccucaaguc ccccggccgc      600

uucgagcgca uccuccuccg cgccgccaac acccacuccu ccgccaagcc cugcggccag      660

caguccaucc accucggcgg cgucuucgag cuccagcccg gcgccuccgu cuucgucaac      720

gucaccgacc ccucccaggu cucccacggc accggcuuca ccuccuucgg ccuccucaag      780

cucuga                                                                 786


<210>  45
<211>  867
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  PDCD1 CDS mRNA opt3

<400>  45
augcagaucc cccaagcccc uuggccagug gucugggcug uucugcagcu cggcuggaga       60

ccgggguggu uccuugacag ccccgauagg ccuuggaacc cacccaccuu uuccccugca      120

cuguuggugg uaacagaggg agacaaugcc acuuucacgu gcucuuuuuc aaacaccagu      180

gagagcuucg uguuaaauug guaccggaug uccccaucua accagacaga uaagcuggcg      240

gcuuuucccg aagaccgcuc gcagccuggu caagauuguc gauuccgugu cacucagcua      300

ccaaauggca gagacuuuca caugucagug guuagggccc ggcgcaacga uagcgggacc      360

uaucucugcg gagcaauuag ucuggccccg aaagcucaga uaaaggaauc ccuuagagca      420

gagcugaggg ugacagaacg gcgcgccgag guccccaccg cucauccuuc uccaagcccc      480

cgaccugccg gccaguucca aacuuuggug guagguguug ucgggggacu ccugggcucc      540

cuggugcucu uagugugggu gcuggcgguc aucuguucaa gagcagccag gggcacaauu      600

ggggcucggc guaccggaca gccacuuaaa gaggacccca gugccguucc gguguuuagc      660

guagauuacg gugaauugga cuuccagugg cgcgagaaga cgccugaacc cccagugccu      720

ugcguccccg agcagacuga guaugcaacc aucguguuuc caucuggcau ggggacaucc      780

ucacccgcua gaaggggaag cgccgauggc ccucggagug cgcaaccacu gcgaccggaa      840

gacggucacu guucuuggcc ccuauga                                          867


<210>  46
<211>  450
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  PDCD1(1-149) CDS mRNA opt3

<400>  46
augcagaucc cccaagcccc uuggccagug gucugggcug uucugcagcu cggcuggaga       60

ccgggguggu uccuugacag ccccgauagg ccuuggaacc cacccaccuu uuccccugca      120

cuguuggugg uaacagaggg agacaaugcc acuuucacgu gcucuuuuuc aaacaccagu      180

gagagcuucg uguuaaauug guaccggaug uccccaucua accagacaga uaagcuggcg      240

gcuuuucccg aagaccgcuc gcagccuggu caagauuguc gauuccgugu cacucagcua      300

ccaaauggca gagacuuuca caugucagug guuagggccc ggcgcaacga uagcgggacc      360

uaucucugcg gagcaauuag ucuggccccg aaagcucaga uaaaggaauc ccuuagagca      420

gagcugaggg ugacagaacg gcgcgccuga                                       450


<210>  47
<211>  660
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  IL12A CDS mRNA opt3

<400>  47
augugccccg ccagaagccu gcuccuugug gcuacccugg ucuuguuaga ccaccugucc       60

cuagcaagga accucccugu ugccacacca gauccgggca uguuccccug ucugcaucac      120

ucucagaauc uucugcgggc ggugucaaac auguugcaaa aggcucgcca gacucucgag      180

uuuuacccuu gcacgaguga agagaucgac caugaagaua uuaccaaaga caagacaagc      240

acuguagagg ccugucugcc acuggaacuc accaaaaaug aguccugcuu aaacucucga      300

gagacaucgu ucauaaccaa ugggucaugu cuggcaagcc guaagacaag uuuuaugaug      360

gcccuuugcu uguccucuau cuaugaagau cugaaaaugu accaggugga guucaagacu      420

augaacgcua agcuacucau ggaccccaaa agacagauuu uucuggauca aaauaugcuu      480

gcagucaucg acgaacugau gcaggccuug aacuucaaua gcgagaccgu gccucagaag      540

uccucacucg aggaaccaga uuuuuauaaa acgaagauua aacuguguau cuuacugcac      600

gcuuucagga uacgggccgu uacuaucgac cgcgugauga guuaccucaa cgcgagcuga      660


<210>  48
<211>  657
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  IL12A(1-219) CDS mRNA opt3

<400>  48
augugccccg ccagaagccu gcuccuugug gcuacccugg ucuuguuaga ccaccugucc       60

cuagcaagga accucccugu ugccacacca gauccgggca uguuccccug ucugcaucac      120

ucucagaauc uucugcgggc ggugucaaac auguugcaaa aggcucgcca gacucucgag      180

uuuuacccuu gcacgaguga agagaucgac caugaagaua uuaccaaaga caagacaagc      240

acuguagagg ccugucugcc acuggaacuc accaaaaaug aguccugcuu aaacucucga      300

gagacaucgu ucauaaccaa ugggucaugu cuggcaagcc guaagacaag uuuuaugaug      360

gcccuuugcu uguccucuau cuaugaagau cugaaaaugu accaggugga guucaagacu      420

augaacgcua agcuacucau ggaccccaaa agacagauuu uucuggauca aaauaugcuu      480

gcagucaucg acgaacugau gcaggccuug aacuucaaua gcgagaccgu gccucagaag      540

uccucacucg aggaaccaga uuuuuauaaa acgaagauua aacuguguau cuuacugcac      600

gcuuucagga uacgggccgu uacuaucgac cgcgugauga guuaccucaa cgcgagc         657


<210>  49
<211>  594
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  IL12A(23-219) CDS mRNA opt3

<400>  49
aggaaccucc cuguugccac accagauccg ggcauguucc ccugucugca ucacucucag       60

aaucuucugc gggcgguguc aaacauguug caaaaggcuc gccagacucu cgaguuuuac      120

ccuugcacga gugaagagau cgaccaugaa gauauuacca aagacaagac aagcacugua      180

gaggccuguc ugccacugga acucaccaaa aaugaguccu gcuuaaacuc ucgagagaca      240

ucguucauaa ccaauggguc augucuggca agccguaaga caaguuuuau gauggcccuu      300

ugcuuguccu cuaucuauga agaucugaaa auguaccagg uggaguucaa gacuaugaac      360

gcuaagcuac ucauggaccc caaaagacag auuuuucugg aucaaaauau gcuugcaguc      420

aucgacgaac ugaugcaggc cuugaacuuc aauagcgaga ccgugccuca gaaguccuca      480

cucgaggaac cagauuuuua uaaaacgaag auuaaacugu guaucuuacu gcacgcuuuc      540

aggauacggg ccguuacuau cgaccgcgug augaguuacc ucaacgcgag cuga            594


<210>  50
<211>  987
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  IL12B CDS mRNA opt3

<400>  50
augugccacc agcaacuggu gaucagcugg uucucccucg ucuuucuugc cucuccccug       60

guugcuauuu gggaguugaa gaaagacgug uacguagugg aauuagauug guauccugac      120

gcaccaggcg agauggucgu gcugaccugu gauacaccgg aagaggacgg gauaacuugg      180

acgcuagauc agucaaguga aguucucgga agcgguaaga cccugacaau ccaggugaaa      240

gaguucggcg acgccgggca guacacuugc cauaagggag gcgagguccu uucccacucu      300

cuguugcucc ugcauaaaaa ggaagauggu auuuggucga ccgacauccu gaaggaucaa      360

aaagagccca agaacaaaac auuucucaga ugugaagcga agaauuauuc agggagguuu      420

accugcuggu gguuaacuac aauuagcacc gaccugacgu ucagugugaa auccucucgg      480

ggaagcuccg auccucaggg cguaacuugu ggcgcugcca cccuuucagc agagcgcguu      540

cgaggggaca acaaggagua cgaauauagu guggagugcc aggaagauag cgccugucca      600

gcugcagagg aaucuuugcc caucgagguc augguggacg ccgugcacaa gcugaaauac      660

gagaauuaua cauccucauu cuuuauacgu gacaucauua agccugaucc acccaaaaac      720

cuacagcuca agccucugaa aaauagcaga caagucgaag uuaguuggga guacccagac      780

acuuggucua ccccgcauuc cuacuucagc cuuacauuuu gcgugcaggu acagggaaag      840

ucgaaaaggg aaaagaagga ucggguguuc accgacaaaa cgucugcuac ugucaucugu      900

cgcaagaacg ccuccauuuc agugagagcg caggauaggu auuacaguag cuccuggucu      960

gagugggcaa gcguucccug cucauga                                          987


<210>  51
<211>  984
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  IL12B(1-328) CDS mRNA opt3

<400>  51
augugccacc agcaacuggu gaucagcugg uucucccucg ucuuucuugc cucuccccug       60

guugcuauuu gggaguugaa gaaagacgug uacguagugg aauuagauug guauccugac      120

gcaccaggcg agauggucgu gcugaccugu gauacaccgg aagaggacgg gauaacuugg      180

acgcuagauc agucaaguga aguucucgga agcgguaaga cccugacaau ccaggugaaa      240

gaguucggcg acgccgggca guacacuugc cauaagggag gcgagguccu uucccacucu      300

cuguugcucc ugcauaaaaa ggaagauggu auuuggucga ccgacauccu gaaggaucaa      360

aaagagccca agaacaaaac auuucucaga ugugaagcga agaauuauuc agggagguuu      420

accugcuggu gguuaacuac aauuagcacc gaccugacgu ucagugugaa auccucucgg      480

ggaagcuccg auccucaggg cguaacuugu ggcgcugcca cccuuucagc agagcgcguu      540

cgaggggaca acaaggagua cgaauauagu guggagugcc aggaagauag cgccugucca      600

gcugcagagg aaucuuugcc caucgagguc augguggacg ccgugcacaa gcugaaauac      660

gagaauuaua cauccucauu cuuuauacgu gacaucauua agccugaucc acccaaaaac      720

cuacagcuca agccucugaa aaauagcaga caagucgaag uuaguuggga guacccagac      780

acuuggucua ccccgcauuc cuacuucagc cuuacauuuu gcgugcaggu acagggaaag      840

ucgaaaaggg aaaagaagga ucggguguuc accgacaaaa cgucugcuac ugucaucugu      900

cgcaagaacg ccuccauuuc agugagagcg caggauaggu auuacaguag cuccuggucu      960

gagugggcaa gcguucccug cuca                                             984


<210>  52
<211>  921
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  IL12B(23-328) CDS mRNA opt3

<400>  52
auuugggagu ugaagaaaga cguguacgua guggaauuag auugguaucc ugacgcacca       60

ggcgagaugg ucgugcugac cugugauaca ccggaagagg acgggauaac uuggacgcua      120

gaucagucaa gugaaguucu cggaagcggu aagacccuga caauccaggu gaaagaguuc      180

ggcgacgccg ggcaguacac uugccauaag ggaggcgagg uccuuuccca cucucuguug      240

cuccugcaua aaaaggaaga ugguauuugg ucgaccgaca uccugaagga ucaaaaagag      300

cccaagaaca aaacauuucu cagaugugaa gcgaagaauu auucagggag guuuaccugc      360

uggugguuaa cuacaauuag caccgaccug acguucagug ugaaauccuc ucggggaagc      420

uccgauccuc agggcguaac uuguggcgcu gccacccuuu cagcagagcg cguucgaggg      480

gacaacaagg aguacgaaua uaguguggag ugccaggaag auagcgccug uccagcugca      540

gaggaaucuu ugcccaucga ggucauggug gacgccgugc acaagcugaa auacgagaau      600

uauacauccu cauucuuuau acgugacauc auuaagccug auccacccaa aaaccuacag      660

cucaagccuc ugaaaaauag cagacaaguc gaaguuaguu gggaguaccc agacacuugg      720

ucuaccccgc auuccuacuu cagccuuaca uuuugcgugc agguacaggg aaagucgaaa      780

agggaaaaga aggaucgggu guucaccgac aaaacgucug cuacugucau cugucgcaag      840

aacgccucca uuucagugag agcgcaggau agguauuaca guagcuccug gucugagugg      900

gcaagcguuc ccugcucaug a                                                921


<210>  53
<211>  54
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Linker-sFvCC49-218 CDS mRNA opt3

<400>  53
ggcagcaccu ccgggucugg aaagcccggu ucaggcgagg ggaguacaaa agga             54


<210>  54
<211>  1632
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  IL12 CDS mRNA opt3

<400>  54
augugccacc agcaacuggu gaucagcugg uucucccucg ucuuucuugc cucuccccug       60

guugcuauuu gggaguugaa gaaagacgug uacguagugg aauuagauug guauccugac      120

gcaccaggcg agauggucgu gcugaccugu gauacaccgg aagaggacgg gauaacuugg      180

acgcuagauc agucaaguga aguucucgga agcgguaaga cccugacaau ccaggugaaa      240

gaguucggcg acgccgggca guacacuugc cauaagggag gcgagguccu uucccacucu      300

cuguugcucc ugcauaaaaa ggaagauggu auuuggucga ccgacauccu gaaggaucaa      360

aaagagccca agaacaaaac auuucucaga ugugaagcga agaauuauuc agggagguuu      420

accugcuggu gguuaacuac aauuagcacc gaccugacgu ucagugugaa auccucucgg      480

ggaagcuccg auccucaggg cguaacuugu ggcgcugcca cccuuucagc agagcgcguu      540

cgaggggaca acaaggagua cgaauauagu guggagugcc aggaagauag cgccugucca      600

gcugcagagg aaucuuugcc caucgagguc augguggacg ccgugcacaa gcugaaauac      660

gagaauuaua cauccucauu cuuuauacgu gacaucauua agccugaucc acccaaaaac      720

cuacagcuca agccucugaa aaauagcaga caagucgaag uuaguuggga guacccagac      780

acuuggucua ccccgcauuc cuacuucagc cuuacauuuu gcgugcaggu acagggaaag      840

ucgaaaaggg aaaagaagga ucggguguuc accgacaaaa cgucugcuac ugucaucugu      900

cgcaagaacg ccuccauuuc agugagagcg caggauaggu auuacaguag cuccuggucu      960

gagugggcaa gcguucccug cucaggcagc accuccgggu cuggaaagcc cgguucaggc     1020

gaggggagua caaaaggaag gaaccucccu guugccacac cagauccggg cauguucccc     1080

ugucugcauc acucucagaa ucuucugcgg gcggugucaa acauguugca aaaggcucgc     1140

cagacucucg aguuuuaccc uugcacgagu gaagagaucg accaugaaga uauuaccaaa     1200

gacaagacaa gcacuguaga ggccugucug ccacuggaac ucaccaaaaa ugaguccugc     1260

uuaaacucuc gagagacauc guucauaacc aaugggucau gucuggcaag ccguaagaca     1320

aguuuuauga uggcccuuug cuuguccucu aucuaugaag aucugaaaau guaccaggug     1380

gaguucaaga cuaugaacgc uaagcuacuc auggacccca aaagacagau uuuucuggau     1440

caaaauaugc uugcagucau cgacgaacug augcaggccu ugaacuucaa uagcgagacc     1500

gugccucaga aguccucacu cgaggaacca gauuuuuaua aaacgaagau uaaacugugu     1560

aucuuacugc acgcuuucag gauacgggcc guuacuaucg accgcgugau gaguuaccuc     1620

aacgcgagcu ga                                                         1632


<210>  55
<211>  786
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  CD40LG CDS mRNA opt3

<400>  55
augaucgaga ccuacaacca gacaagcccc agauccgccg cuacuggccu gccuauuucu       60

augaagauau ucauguaucu ccuuacggug uuucugauca cccaaaugau ugggucagca      120

uuguucgccg ucuacuuaca caggcggcug gacaaaaucg aagaugagcg caaucuacau      180

gaagacuuug uuuucaugaa gacaauucag cgaugcaaca cuggagagcg uagucucagc      240

cugcuuaauu gugaagagau caaaucccag uuugaggguu ucgugaagga uauaaugcug      300

aacaaagaag agaccaagaa ggaaaauucu uuugagaugc agaaaggcga ccaaaaccca      360

cagaucgcgg cucacguaau uucggaggcc ucaagcaaga caaccagugu guugcagugg      420

gcagaaaaag gguauuacac uauguccaau aaccucguca cacuggagaa uggaaagcag      480

cugaccguga aaagacaagg ccucuauuac aucuaugccc agguuacguu cugcucuaac      540

agggaagcua gcucccaggc accguuuauu gccucauuau gucugaagag ucccggucgg      600

uucgagcgca uccuuuugag agcugccaau acucauagcu cugcgaagcc uugcgggcag      660

caauccauac accugggagg cguguuugaa cuacagccag gcgcaucagu cuucgugaac      720

guaaccgauc ccagccaggu uagucauggg acaggauuua cuucuuucgg ucuccugaaa      780

cuuuga                                                                 786


<210>  56
<211>  867
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  PDCD1 CDS mRNA opt3v

<400>  56
augcagaucc cucaggcucc uuggccuguu gugugggcug uucugcaacu uggauggcgg       60

ccuggcuggu uccuggacuc uccugacaga cccuggaauc cuccaacauu cagccccgcu      120

cugcuggugg uuaccgaggg cgauaaugcc accuucaccu guagcuucag caacaccagc      180

gagagcuucg ugcugaacug guacagaaug agccccagca accagaccga caagcuggcc      240

gccuuuccug aggauagauc ucagcccggc caggacugcc gguucagagu uacacagcug      300

cccaacggcc gggacuucca caugucuguc guccgggcca gaagaaacga cagcggcaca      360

uaucugugcg gcgccauuuc ucuggccccu aaggcucaga ucaaagagag ccugagagcc      420

gagcugagag ugacagaaag acgggccgaa gugcccacag cucacccuuc accuucucca      480

agaccugccg gccaguucca gacacugguc gugggaguug uuggcggacu gcugggaucu      540

cuggugcugc uuguuugggu gcucgccgug aucuguagca gagccgccag aggaacaauc      600

ggcgccagaa ggacaggcca gccucugaaa gaggaucccu cugcuguccc cguguucagc      660

guggacuaug gcgagcugga uuuccagugg cgggaaaaga cacccgagcc uccagugccu      720

ugugugccug agcagacaga guacgccacc aucguguucc cuagcggcau gggcacaucu      780

agcccugcca gaagaggauc ugccgacgga ccuagaucug cccagccucu cagaccugag      840

gauggccacu guagcuggcc ucuguaa                                          867


<210>  57
<211>  450
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  PDCD1(1-149) CDS mRNA opt3v

<400>  57
augcagaucc cucaggcucc uuggccuguu gugugggcug uucugcaacu uggauggcgg       60

ccuggcuggu uccuggacuc uccugacaga cccuggaauc cuccaacauu cagccccgcu      120

cugcuggugg uuaccgaggg cgauaaugcc accuucaccu guagcuucag caacaccagc      180

gagagcuucg ugcugaacug guacagaaug agccccagca accagaccga caagcuggcc      240

gccuuuccug aggauagauc ucagcccggc caggacugcc gguucagagu uacacagcug      300

cccaacggcc gggacuucca caugucuguc guccgggcca gaagaaacga cagcggcaca      360

uaucugugcg gcgccauuuc ucuggccccu aaggcucaga ucaaagagag ccugagagcc      420

gagcugagag ugacagaaag acgggccuga                                       450


<210>  58
<211>  660
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  IL12A CDS mRNA opt3v

<400>  58
augugcccug ccagaucucu gcugcuggug gcuacacugg ugcugcugga ucaucugagc       60

cuggccagaa accugccagu ggccacgccu gauccuggca uguuuccuug ucugcaccac      120

agccagaacc ugcugagagc cguguccaac augcugcaga aggccagaca gacccucgag      180

uucuaccccu gcaccagcga ggaaaucgac cacgaggaca ucaccaagga caagaccagc      240

accguggaag ccugccugcc ucuggaacug accaagaacg agagcugccu gaacagccgg      300

gaaaccagcu ucaucaccaa cggcucuugc cuggccucca gaaagaccuc cuucaugaug      360

gcccugugcc ugagcagcau cuacgaggac cugaagaugu accaggucga guucaagacc      420

augaacgcca agcugcugau ggaccccaag cggcagaucu uccuggacca gaauaugcug      480

gccgugaucg acgagcugau gcaggcccug aacuucaaca gcgagacagu gccccagaag      540

uccagccugg aagaacccga cuucuacaag accaagauca agcugugcau ccugcugcac      600

gccuuccgga ucagagccgu gaccaucgac agagugauga gcuaccugaa cgccuccuga      660


<210>  59
<211>  657
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  IL12A(1-219) CDS mRNA opt3v

<400>  59
augugcccug ccagaucucu gcugcuggug gcuacacugg ugcugcugga ucaucugagc       60

cuggccagaa accugccagu ggccacgccu gauccuggca uguuuccuug ucugcaccac      120

agccagaacc ugcugagagc cguguccaac augcugcaga aggccagaca gacccucgag      180

uucuaccccu gcaccagcga ggaaaucgac cacgaggaca ucaccaagga caagaccagc      240

accguggaag ccugccugcc ucuggaacug accaagaacg agagcugccu gaacagccgg      300

gaaaccagcu ucaucaccaa cggcucuugc cuggccucca gaaagaccuc cuucaugaug      360

gcccugugcc ugagcagcau cuacgaggac cugaagaugu accaggucga guucaagacc      420

augaacgcca agcugcugau ggaccccaag cggcagaucu uccuggacca gaauaugcug      480

gccgugaucg acgagcugau gcaggcccug aacuucaaca gcgagacagu gccccagaag      540

uccagccugg aagaacccga cuucuacaag accaagauca agcugugcau ccugcugcac      600

gccuuccgga ucagagccgu gaccaucgac agagugauga gcuaccugaa cgccucc         657


<210>  60
<211>  594
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  IL12A(23-219) CDS mRNA opt3v

<400>  60
agaaaccugc caguggccac gccugauccu ggcauguuuc cuugucugca ccacagccag       60

aaccugcuga gagccguguc caacaugcug cagaaggcca gacagacccu cgaguucuac      120

cccugcacca gcgaggaaau cgaccacgag gacaucacca aggacaagac cagcaccgug      180

gaagccugcc ugccucugga acugaccaag aacgagagcu gccugaacag ccgggaaacc      240

agcuucauca ccaacggcuc uugccuggcc uccagaaaga ccuccuucau gauggcccug      300

ugccugagca gcaucuacga ggaccugaag auguaccagg ucgaguucaa gaccaugaac      360

gccaagcugc ugauggaccc caagcggcag aucuuccugg accagaauau gcuggccgug      420

aucgacgagc ugaugcaggc ccugaacuuc aacagcgaga cagugcccca gaaguccagc      480

cuggaagaac ccgacuucua caagaccaag aucaagcugu gcauccugcu gcacgccuuc      540

cggaucagag ccgugaccau cgacagagug augagcuacc ugaacgccuc cuga            594


<210>  61
<211>  987
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  IL12B CDS mRNA opt3v

<400>  61
augugucacc agcagcuggu caucagcugg uucagccugg uguuccuggc cucuccucug       60

guggccaucu gggagcugaa gaaagacgug uacguggugg aacuggacug guaucccgau      120

gcuccuggcg agaugguggu gcugaccugc gauaccccug aagaggacgg caucaccugg      180

acacuggauc agucuagcga ggugcucggc agcggcaaga cccugaccau ccaagugaaa      240

gaguuuggcg acgccggcca guacaccugu cacaaaggcg gagaagugcu gagccacagc      300

cugcugcugc uccacaagaa agaggauggc auuuggagca ccgacauccu gaaggaccag      360

aaagagccca agaacaagac cuuccugaga ugcgaggcca agaacuacag cggccgguuc      420

acauguuggu ggcugaccac caucagcacc gaccugaccu ucagcgugaa guccagcaga      480

ggcagcagug auccucaggg cguuacaugu ggcgccgcua cacugucugc cgaaagagug      540

cggggcgaca acaaagaaua cgaguacagc guggaaugcc aagaggacag cgccugucca      600

gccgccgaag agucucugcc uaucgaagug augguggacg ccgugcacaa gcugaaguac      660

gagaacuaca ccuccagcuu uuucauccgg gacaucauca agcccgaucc uccaaagaac      720

cugcagcuga agccucugaa gaacagcaga cagguggaag uguccuggga guaccccgac      780

accuggucua caccccacag cuacuucagc cugaccuuuu gcgugcaagu gcagggcaag      840

uccaagcgcg agaaaaagga ccggguguuc accgacaaga ccagcgccac cgugaucugc      900

agaaagaacg ccagcaucag cgucagagcc caggaccggu acuacagcag cucuuggagc      960

gaaugggcca gcgugccaug uagcuaa                                          987


<210>  62
<211>  984
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  IL12B(1-328) CDS mRNA opt3v

<400>  62
augugucacc agcagcuggu caucagcugg uucagccugg uguuccuggc cucuccucug       60

guggccaucu gggagcugaa gaaagacgug uacguggugg aacuggacug guaucccgau      120

gcuccuggcg agaugguggu gcugaccugc gauaccccug aagaggacgg caucaccugg      180

acacuggauc agucuagcga ggugcucggc agcggcaaga cccugaccau ccaagugaaa      240

gaguuuggcg acgccggcca guacaccugu cacaaaggcg gagaagugcu gagccacagc      300

cugcugcugc uccacaagaa agaggauggc auuuggagca ccgacauccu gaaggaccag      360

aaagagccca agaacaagac cuuccugaga ugcgaggcca agaacuacag cggccgguuc      420

acauguuggu ggcugaccac caucagcacc gaccugaccu ucagcgugaa guccagcaga      480

ggcagcagug auccucaggg cguuacaugu ggcgccgcua cacugucugc cgaaagagug      540

cggggcgaca acaaagaaua cgaguacagc guggaaugcc aagaggacag cgccugucca      600

gccgccgaag agucucugcc uaucgaagug augguggacg ccgugcacaa gcugaaguac      660

gagaacuaca ccuccagcuu uuucauccgg gacaucauca agcccgaucc uccaaagaac      720

cugcagcuga agccucugaa gaacagcaga cagguggaag uguccuggga guaccccgac      780

accuggucua caccccacag cuacuucagc cugaccuuuu gcgugcaagu gcagggcaag      840

uccaagcgcg agaaaaagga ccggguguuc accgacaaga ccagcgccac cgugaucugc      900

agaaagaacg ccagcaucag cgucagagcc caggaccggu acuacagcag cucuuggagc      960

gaaugggcca gcgugccaug uagc                                             984


<210>  63
<211>  921
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  IL12B(23-328) CDS mRNA opt3v

<400>  63
aucugggagc ugaagaaaga cguguacgug guggaacugg acugguaucc cgaugcuccu       60

ggcgagaugg uggugcugac cugcgauacc ccugaagagg acggcaucac cuggacacug      120

gaucagucua gcgaggugcu cggcagcggc aagacccuga ccauccaagu gaaagaguuu      180

ggcgacgccg gccaguacac cugucacaaa ggcggagaag ugcugagcca cagccugcug      240

cugcuccaca agaaagagga uggcauuugg agcaccgaca uccugaagga ccagaaagag      300

cccaagaaca agaccuuccu gagaugcgag gccaagaacu acagcggccg guucacaugu      360

ugguggcuga ccaccaucag caccgaccug accuucagcg ugaaguccag cagaggcagc      420

agugauccuc agggcguuac auguggcgcc gcuacacugu cugccgaaag agugcggggc      480

gacaacaaag aauacgagua cagcguggaa ugccaagagg acagcgccug uccagccgcc      540

gaagagucuc ugccuaucga agugauggug gacgccgugc acaagcugaa guacgagaac      600

uacaccucca gcuuuuucau ccgggacauc aucaagcccg auccuccaaa gaaccugcag      660

cugaagccuc ugaagaacag cagacaggug gaaguguccu gggaguaccc cgacaccugg      720

ucuacacccc acagcuacuu cagccugacc uuuugcgugc aagugcaggg caaguccaag      780

cgcgagaaaa aggaccgggu guucaccgac aagaccagcg ccaccgugau cugcagaaag      840

aacgccagca ucagcgucag agcccaggac cgguacuaca gcagcucuug gagcgaaugg      900

gccagcgugc cauguagcua a                                                921


<210>  64
<211>  54
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Linker-sFvCC49-218 CDS mRNA opt3v

<400>  64
ggcucuacau cuggcucugg caaaccugga ucuggcgagg gcucuacaaa gggc             54


<210>  65
<211>  1632
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  IL12 CDS mRNA opt3v

<400>  65
augugucacc agcagcuggu caucagcugg uucagccugg uguuccuggc cucuccucug       60

guggccaucu gggagcugaa gaaagacgug uacguggugg aacuggacug guaucccgau      120

gcuccuggcg agaugguggu gcugaccugc gauaccccug aagaggacgg caucaccugg      180

acacuggauc agucuagcga ggugcucggc agcggcaaga cccugaccau ccaagugaaa      240

gaguuuggcg acgccggcca guacaccugu cacaaaggcg gagaagugcu gagccacagc      300

cugcugcugc uccacaagaa agaggauggc auuuggagca ccgacauccu gaaggaccag      360

aaagagccca agaacaagac cuuccugaga ugcgaggcca agaacuacag cggccgguuc      420

acauguuggu ggcugaccac caucagcacc gaccugaccu ucagcgugaa guccagcaga      480

ggcagcagug auccucaggg cguuacaugu ggcgccgcua cacugucugc cgaaagagug      540

cggggcgaca acaaagaaua cgaguacagc guggaaugcc aagaggacag cgccugucca      600

gccgccgaag agucucugcc uaucgaagug augguggacg ccgugcacaa gcugaaguac      660

gagaacuaca ccuccagcuu uuucauccgg gacaucauca agcccgaucc uccaaagaac      720

cugcagcuga agccucugaa gaacagcaga cagguggaag uguccuggga guaccccgac      780

accuggucua caccccacag cuacuucagc cugaccuuuu gcgugcaagu gcagggcaag      840

uccaagcgcg agaaaaagga ccggguguuc accgacaaga ccagcgccac cgugaucugc      900

agaaagaacg ccagcaucag cgucagagcc caggaccggu acuacagcag cucuuggagc      960

gaaugggcca gcgugccaug uagcggcucu acaucuggcu cuggcaaacc uggaucuggc     1020

gagggcucua caaagggcag aaaccugcca guggccacgc cugauccugg cauguuuccu     1080

ugucugcacc acagccagaa ccugcugaga gccgugucca acaugcugca gaaggccaga     1140

cagacccucg aguucuaccc cugcaccagc gaggaaaucg accacgagga caucaccaag     1200

gacaagacca gcaccgugga agccugccug ccucuggaac ugaccaagaa cgagagcugc     1260

cugaacagcc gggaaaccag cuucaucacc aacggcucuu gccuggccuc cagaaagacc     1320

uccuucauga uggcccugug ccugagcagc aucuacgagg accugaagau guaccagguc     1380

gaguucaaga ccaugaacgc caagcugcug auggacccca agcggcagau cuuccuggac     1440

cagaauaugc uggccgugau cgacgagcug augcaggccc ugaacuucaa cagcgagaca     1500

gugccccaga aguccagccu ggaagaaccc gacuucuaca agaccaagau caagcugugc     1560

auccugcugc acgccuuccg gaucagagcc gugaccaucg acagagugau gagcuaccug     1620

aacgccuccu ga                                                         1632


<210>  66
<211>  786
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  CD40LG CDS mRNA opt3v

<400>  66
augaucgaga cauacaacca gacaagcccc agaagcgccg ccacaggacu gccuaucagc       60

augaagaucu uuauguaccu gcugaccgug uuccugauca cccagaugau cggcagcgcc      120

cuguuugccg uguaccugca cagacggcug gacaagaucg aggacgagag aaaccugcac      180

gaggacuucg uguucaugaa gaccauccag cggugcaaca ccggcgagag aagucugagc      240

cugcugaacu gcgaggaaau caagagccag uucgagggcu ucgugaagga caucaugcug      300

aacaaagagg aaacgaagaa agaaaacucc uucgagaugc agaagggcga ccagaauccu      360

cagaucgccg cucacgugau cagcgaggcc agcagcaaga caacaagcgu gcugcagugg      420

gccgagaagg gcuacuacac caugagcaac aaccugguca cccuggaaaa cggcaagcag      480

cugacaguga agcggcaggg ccuguacuac aucuacgccc aagugaccuu cugcagcaac      540

agagaggcca gcucucaggc cccuuuuauc gccagccugu gccugaaguc cccuggcaga      600

uucgagcgga uucugcugag agccgccaac acacacagca gcgccaaacc uuguggccag      660

cagucuauuc accucggcgg aguguuugag cugcagccug gcgcaagcgu guucgugaau      720

gugacagacc cuagccaggu gucccacggc accggcuuua caucuuucgg acugcugaag      780

cuguga                                                                 786


<210>  67
<211>  867
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  PDCD1 CDS mRNA opt4

<400>  67
augcagaucc cccaggcccc cuggcccgug gugugggccg ugcugcagcu gggcuggaga       60

cccggcuggu uccuggacag ccccgacaga cccuggaacc cccccaccuu cagccccgcc      120

cugcuggugg ugaccgaggg cgacaacgcc accuucaccu guagcuucag caacaccagc      180

gagagcuucg ugcugaacug guacagaaug agccccagca accagaccga caagcuggcc      240

gccuuccccg aggacagaag ccagcccggc caggacugca gauucagagu gacccagcug      300

cccaacggca gagacuucca caugagcgug gugagagcca gaagaaacga cagcggcacc      360

uaccugugcg gcgccaucag ccuggccccc aaggcccaga ucaaggagag ccugagagcc      420

gagcugagag ugaccgagag aagggccgag gugcccaccg cccaccccag ccccagcccc      480

agacccgccg gccaguucca gacccuggug gugggcgugg ugggcggccu gcugggcagc      540

cuggugcugc uggugugggu gcuggccgug aucugcagca gagccgccag aggcaccauc      600

ggcgccagaa gaaccggcca gccccugaag gaggacccca gcgccgugcc cguguucagc      660

guggacuacg gcgagcugga cuuccagugg agagagaaga cccccgagcc ccccgugccc      720

ugcgugcccg agcagaccga guacgccacc aucguguucc ccagcggcau gggcaccagc      780

agccccgcca gaagaggcag cgccgacggc cccagaagcg cccagccccu gagacccgag      840

gacggccacu gcagcuggcc ccuguga                                          867


<210>  68
<211>  450
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  PDCD1(1-149) CDS mRNA opt4

<400>  68
augcagaucc cccaggcccc cuggcccgug gugugggccg ugcugcagcu gggcuggaga       60

cccggcuggu uccuggacag ccccgacaga cccuggaacc cccccaccuu cagccccgcc      120

cugcuggugg ugaccgaggg cgacaacgcc accuucaccu guagcuucag caacaccagc      180

gagagcuucg ugcugaacug guacagaaug agccccagca accagaccga caagcuggcc      240

gccuuccccg aggacagaag ccagcccggc caggacugca gauucagagu gacccagcug      300

cccaacggca gagacuucca caugagcgug gugagagcca gaagaaacga cagcggcacc      360

uaccugugcg gcgccaucag ccuggccccc aaggcccaga ucaaggagag ccugagagcc      420

gagcugagag ugaccgagag aagggccuga                                       450


<210>  69
<211>  660
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  IL12A CDS mRNA opt4

<400>  69
augugccccg ccagaagccu gcugcuggug gccacccugg ugcugcugga ccaccugagc       60

cuggccagaa accugcccgu ggccaccccc gaccccggca uguuccccug ccugcaccac      120

agccagaacc ugcugagagc cgugagcaac augcugcaga aggccagaca gacccuggag      180

uucuaccccu gcaccagcga ggagaucgac cacgaggaca ucaccaagga caagaccagc      240

accguggagg ccugccugcc ccuggagcug accaagaacg agagcugccu gaacagcaga      300

gagaccagcu ucaucaccaa cggcagcugc cuggccagca gaaagaccag cuucaugaug      360

gcccugugcc ugagcagcau cuacgaggac cugaagaugu accaggugga guucaagacc      420

augaacgcca agcugcugau ggaccccaag agacagaucu uccuggacca gaacaugcug      480

gccgugaucg acgagcugau gcaggcccug aacuucaaca gcgagaccgu gccccagaag      540

aguagccugg aggagcccga cuucuacaag accaagauca agcugugcau ccugcugcac      600

gccuucagaa ucagagccgu gaccaucgac agagugauga gcuaccugaa cgccagcuga      660


<210>  70
<211>  657
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  IL12A(1-219) CDS mRNA opt4

<400>  70
augugccccg ccagaagccu gcugcuggug gccacccugg ugcugcugga ccaccugagc       60

cuggccagaa accugcccgu ggccaccccc gaccccggca uguuccccug ccugcaccac      120

agccagaacc ugcugagagc cgugagcaac augcugcaga aggccagaca gacccuggag      180

uucuaccccu gcaccagcga ggagaucgac cacgaggaca ucaccaagga caagaccagc      240

accguggagg ccugccugcc ccuggagcug accaagaacg agagcugccu gaacagcaga      300

gagaccagcu ucaucaccaa cggcagcugc cuggccagca gaaagaccag cuucaugaug      360

gcccugugcc ugagcagcau cuacgaggac cugaagaugu accaggugga guucaagacc      420

augaacgcca agcugcugau ggaccccaag agacagaucu uccuggacca gaacaugcug      480

gccgugaucg acgagcugau gcaggcccug aacuucaaca gcgagaccgu gccccagaag      540

aguagccugg aggagcccga cuucuacaag accaagauca agcugugcau ccugcugcac      600

gccuucagaa ucagagccgu gaccaucgac agagugauga gcuaccugaa cgccagc         657


<210>  71
<211>  594
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  IL12A(23-219) CDS mRNA opt4

<400>  71
agaaaccugc ccguggccac ccccgacccc ggcauguucc ccugccugca ccacagccag       60

aaccugcuga gagccgugag caacaugcug cagaaggcca gacagacccu ggaguucuac      120

cccugcacca gcgaggagau cgaccacgag gacaucacca aggacaagac cagcaccgug      180

gaggccugcc ugccccugga gcugaccaag aacgagagcu gccugaacag cagagagacc      240

agcuucauca ccaacggcag cugccuggcc agcagaaaga ccagcuucau gauggcccug      300

ugccugagca gcaucuacga ggaccugaag auguaccagg uggaguucaa gaccaugaac      360

gccaagcugc ugauggaccc caagagacag aucuuccugg accagaacau gcuggccgug      420

aucgacgagc ugaugcaggc ccugaacuuc aacagcgaga ccgugcccca gaagaguagc      480

cuggaggagc ccgacuucua caagaccaag aucaagcugu gcauccugcu gcacgccuuc      540

agaaucagag ccgugaccau cgacagagug augagcuacc ugaacgccag cuga            594


<210>  72
<211>  987
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  IL12B CDS mRNA opt4

<400>  72
augugccacc agcagcuggu gaucagcugg uucagccugg uguuccuggc cagcccccug       60

guggccaucu gggagcugaa gaaggacgug uacguggugg agcuggacug guaccccgac      120

gcccccggcg agaugguggu gcugaccugc gacacccccg aggaggacgg caucaccugg      180

acccuggacc agagcagcga ggugcugggc agcggcaaga cccugaccau ccaggugaag      240

gaguucggcg acgccggcca guacaccugu cacaagggcg gcgaggugcu gagccacagc      300

cugcugcugc ugcacaagaa ggaggacggc aucuggagca ccgacauccu gaaggaccag      360

aaggagccca agaacaagac cuuccugaga ugcgaggcca agaacuacag cggcagauuc      420

accuguuggu ggcugaccac caucagcacc gaccugaccu ucagcgugaa gaguagcaga      480

ggcagcagcg acccccaggg cgugaccugc ggcgccgcca cccugagcgc cgagagagug      540

agaggcgaca acaaggagua cgaguacagc guggagugcc aggaggacag cgccugcccc      600

gccgccgagg agagccugcc caucgaggug augguggacg ccgugcacaa gcugaaguac      660

gagaacuaca ccagcagcuu cuucaucaga gacaucauca agcccgaccc ccccaagaac      720

cugcagcuga agccccugaa gaacagcaga cagguggagg ugagcuggga guaccccgac      780

accuggagca ccccccacag cuacuucagc cugaccuucu gcgugcaggu ucagggcaag      840

agcaagagag agaagaagga cagaguguuc accgacaaga ccagcgccac cgugaucugc      900

agaaagaacg ccagcaucag cgugagagcc caggacagau acuacagcag cagcuggagc      960

gagugggcca gcgugcccug cagcuga                                          987


<210>  73
<211>  984
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  IL12B(1-328) CDS mRNA opt4

<400>  73
augugccacc agcagcuggu gaucagcugg uucagccugg uguuccuggc cagcccccug       60

guggccaucu gggagcugaa gaaggacgug uacguggugg agcuggacug guaccccgac      120

gcccccggcg agaugguggu gcugaccugc gacacccccg aggaggacgg caucaccugg      180

acccuggacc agagcagcga ggugcugggc agcggcaaga cccugaccau ccaggugaag      240

gaguucggcg acgccggcca guacaccugu cacaagggcg gcgaggugcu gagccacagc      300

cugcugcugc ugcacaagaa ggaggacggc aucuggagca ccgacauccu gaaggaccag      360

aaggagccca agaacaagac cuuccugaga ugcgaggcca agaacuacag cggcagauuc      420

accuguuggu ggcugaccac caucagcacc gaccugaccu ucagcgugaa gaguagcaga      480

ggcagcagcg acccccaggg cgugaccugc ggcgccgcca cccugagcgc cgagagagug      540

agaggcgaca acaaggagua cgaguacagc guggagugcc aggaggacag cgccugcccc      600

gccgccgagg agagccugcc caucgaggug augguggacg ccgugcacaa gcugaaguac      660

gagaacuaca ccagcagcuu cuucaucaga gacaucauca agcccgaccc ccccaagaac      720

cugcagcuga agccccugaa gaacagcaga cagguggagg ugagcuggga guaccccgac      780

accuggagca ccccccacag cuacuucagc cugaccuucu gcgugcaggu ucagggcaag      840

agcaagagag agaagaagga cagaguguuc accgacaaga ccagcgccac cgugaucugc      900

agaaagaacg ccagcaucag cgugagagcc caggacagau acuacagcag cagcuggagc      960

gagugggcca gcgugcccug cagc                                             984


<210>  74
<211>  921
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  IL12B(23-328) CDS mRNA opt4

<400>  74
aucugggagc ugaagaagga cguguacgug guggagcugg acugguaccc cgacgccccc       60

ggcgagaugg uggugcugac cugcgacacc cccgaggagg acggcaucac cuggacccug      120

gaccagagca gcgaggugcu gggcagcggc aagacccuga ccauccaggu gaaggaguuc      180

ggcgacgccg gccaguacac cugucacaag ggcggcgagg ugcugagcca cagccugcug      240

cugcugcaca agaaggagga cggcaucugg agcaccgaca uccugaagga ccagaaggag      300

cccaagaaca agaccuuccu gagaugcgag gccaagaacu acagcggcag auucaccugu      360

ugguggcuga ccaccaucag caccgaccug accuucagcg ugaagaguag cagaggcagc      420

agcgaccccc agggcgugac cugcggcgcc gccacccuga gcgccgagag agugagaggc      480

gacaacaagg aguacgagua cagcguggag ugccaggagg acagcgccug ccccgccgcc      540

gaggagagcc ugcccaucga ggugauggug gacgccgugc acaagcugaa guacgagaac      600

uacaccagca gcuucuucau cagagacauc aucaagcccg acccccccaa gaaccugcag      660

cugaagcccc ugaagaacag cagacaggug gaggugagcu gggaguaccc cgacaccugg      720

agcacccccc acagcuacuu cagccugacc uucugcgugc agguucaggg caagagcaag      780

agagagaaga aggacagagu guucaccgac aagaccagcg ccaccgugau cugcagaaag      840

aacgccagca ucagcgugag agcccaggac agauacuaca gcagcagcug gagcgagugg      900

gccagcgugc ccugcagcug a                                                921


<210>  75
<211>  54
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Linker-sFvCC49-218 CDS mRNA opt4

<400>  75
ggcagcacca gcggcagcgg caagcccggc agcggcgagg gcagcaccaa gggc             54


<210>  76
<211>  1632
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  IL12 CDS mRNA opt4

<400>  76
augugccacc agcagcuggu gaucagcugg uucagccugg uguuccuggc cagcccccug       60

guggccaucu gggagcugaa gaaggacgug uacguggugg agcuggacug guaccccgac      120

gcccccggcg agaugguggu gcugaccugc gacacccccg aggaggacgg caucaccugg      180

acccuggacc agagcagcga ggugcugggc agcggcaaga cccugaccau ccaggugaag      240

gaguucggcg acgccggcca guacaccugu cacaagggcg gcgaggugcu gagccacagc      300

cugcugcugc ugcacaagaa ggaggacggc aucuggagca ccgacauccu gaaggaccag      360

aaggagccca agaacaagac cuuccugaga ugcgaggcca agaacuacag cggcagauuc      420

accuguuggu ggcugaccac caucagcacc gaccugaccu ucagcgugaa gaguagcaga      480

ggcagcagcg acccccaggg cgugaccugc ggcgccgcca cccugagcgc cgagagagug      540

agaggcgaca acaaggagua cgaguacagc guggagugcc aggaggacag cgccugcccc      600

gccgccgagg agagccugcc caucgaggug augguggacg ccgugcacaa gcugaaguac      660

gagaacuaca ccagcagcuu cuucaucaga gacaucauca agcccgaccc ccccaagaac      720

cugcagcuga agccccugaa gaacagcaga cagguggagg ugagcuggga guaccccgac      780

accuggagca ccccccacag cuacuucagc cugaccuucu gcgugcaggu ucagggcaag      840

agcaagagag agaagaagga cagaguguuc accgacaaga ccagcgccac cgugaucugc      900

agaaagaacg ccagcaucag cgugagagcc caggacagau acuacagcag cagcuggagc      960

gagugggcca gcgugcccug cagcggcagc accagcggca gcggcaagcc cggcagcggc     1020

gagggcagca ccaagggcag aaaccugccc guggccaccc ccgaccccgg cauguucccc     1080

ugccugcacc acagccagaa ccugcugaga gccgugagca acaugcugca gaaggccaga     1140

cagacccugg aguucuaccc cugcaccagc gaggagaucg accacgagga caucaccaag     1200

gacaagacca gcaccgugga ggccugccug ccccuggagc ugaccaagaa cgagagcugc     1260

cugaacagca gagagaccag cuucaucacc aacggcagcu gccuggccag cagaaagacc     1320

agcuucauga uggcccugug ccugagcagc aucuacgagg accugaagau guaccaggug     1380

gaguucaaga ccaugaacgc caagcugcug auggacccca agagacagau cuuccuggac     1440

cagaacaugc uggccgugau cgacgagcug augcaggccc ugaacuucaa cagcgagacc     1500

gugccccaga agaguagccu ggaggagccc gacuucuaca agaccaagau caagcugugc     1560

auccugcugc acgccuucag aaucagagcc gugaccaucg acagagugau gagcuaccug     1620

aacgccagcu ga                                                         1632


<210>  77
<211>  786
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  CD40LG CDS mRNA opt4

<400>  77
augaucgaga ccuacaacca gaccagcccc agaagcgccg ccaccggccu gcccaucagc       60

augaagaucu ucauguaccu gcugaccgug uuccugauca cccagaugau cggcagcgcc      120

cuguucgccg uguaccugca cagaagacug gacaagaucg aggacgagag aaaccugcac      180

gaggacuucg uguucaugaa gaccauccag agaugcaaca ccggcgagag aagccugagc      240

cugcugaacu gcgaggagau caagagccag uucgagggcu ucgugaagga caucaugcug      300

aacaaggagg agaccaagaa ggagaacagc uucgagaugc agaagggcga ccagaacccc      360

cagaucgccg cccacgugau cagcgaggcc agcagcaaga ccaccagcgu gcugcagugg      420

gccgagaagg gcuacuacac caugagcaac aaccugguga cccuggagaa cggcaagcag      480

cugaccguga agagacaggg ccuguacuac aucuacgccc aggugaccuu cugcagcaac      540

agagaggcca gcagccaggc ccccuucauc gccagccugu gccugaagag ucccggcaga      600

uucgagagaa uccugcugag agccgccaac acccacagca gcgccaagcc cugcggccag      660

cagagcaucc accugggcgg cguguucgag cugcagcccg gcgccagcgu guucgugaac      720

gugaccgacc ccagccaggu gagccacggc accggcuuca ccagcuucgg ccugcugaag      780

cuguga                                                                 786


<210>  78
<211>  867
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  PDCD1 CDS mRNA opt5

<400>  78
augcagaucc cccaagcccc uuggccggug gucugggcug uucugcagcu cggcuggaga       60

cccggguggu uccuggacag cccugaucgg cccuggaacc cucccaccuu uuccccugcc      120

cuucuggugg ugacagaggg agacaaugcg acguuuaccu gcucuuucag caacacaucc      180

gaaucuuucg uccucaauug guaccgcaug agcccgucca accagaccga uaagcuggcu      240

gccuuucccg aggacagauc ucagccuggc caagauuguc gguuccgcgu gacacagcuu      300

cccaauggga gagacuuuca caugagcguu gugcgggccc gcagaaacga uuccggaacc      360

uaucugugcg gcgcuauuag ccucgccccu aaagcucaga ucaaggaauc ucugcgggcc      420

gagcugcgcg ucacagaaag acgggcggag gugcccaccg cccauccguc cccuagcccc      480

cgcccugcug ggcaguucca aacgcucguu gugggagucg ugggcggccu gcuugggucu      540

cuggugcucc uggucugggu ucuugccgug auuuguucca gagcugcccg gggaaccauc      600

ggcgcgcgca gaacagggca gccccugaaa gaggacccca gcgccgugcc ugucuuuucu      660

guggauuacg gagaacucga cuuccagugg cgggagaaga ccccggaacc cccuguuccc      720

ugcgugccug agcagacaga guaugcuacc auugucuuuc ccuccggcau ggggacgagc      780

uccccggcca gacgcggauc ugcugauggc ccucggagcg cccaaccccu gagaccugaa      840

gacggccacu guuccuggcc ccuguga                                          867


<210>  79
<211>  450
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  PDCD1(1-149) CDS mRNA opt5

<400>  79
augcagaucc cccaagcccc uuggccggug gucugggcug uucugcagcu cggcuggaga       60

cccggguggu uccuggacag cccugaucgg cccuggaacc cucccaccuu uuccccugcc      120

cuucuggugg ugacagaggg agacaaugcg acguuuaccu gcucuuucag caacacaucc      180

gaaucuuucg uccucaauug guaccgcaug agcccgucca accagaccga uaagcuggcu      240

gccuuucccg aggacagauc ucagccuggc caagauuguc gguuccgcgu gacacagcuu      300

cccaauggga gagacuuuca caugagcguu gugcgggccc gcagaaacga uuccggaacc      360

uaucugugcg gcgcuauuag ccucgccccu aaagcucaga ucaaggaauc ucugcgggcc      420

gagcugcgcg ucacagaaag acgggcguga                                       450


<210>  80
<211>  660
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  IL12A CDS mRNA opt5

<400>  80
augugccccg ccagaagccu gcuccuggug gcuacccuug uccugcucga ccaccugucc       60

cuugcccgga accugccugu ugcgacaccg gaucccggca uguucccuug ucuccaucac      120

ucucagaauc ugcugcgcgc ugugagcaac augcuccaaa aggccagaca gacgcuggag      180

uuuuaccccu gcaccuccga agagaucgac caugaagaua uuacaaaaga caagaccucu      240

acaguggagg ccugucuucc ucuggaacuc accaaaaaug agagcugccu gaacucccgg      300

gagacaucuu ucaucaccaa ugggagcugu cuugcuuccc gcaagacgag cuuuaugaug      360

gcccugugcc ucucuuccau uuaugaagau cugaaaaugu accaggucga guucaagacc      420

augaacgcua agcugcucau ggaccccaaa agacagaucu uucuggauca aaauaugcuu      480

gccgugauug acgaacugau gcaggcgcuc aacuucaaua gcgagacagu uccucagaag      540

ucuucccugg aggaaccgga uuuuuauaaa accaagauca aacuuuguau ccugcuccac      600

gccuuccgga uucgcgcugu gacaaucgac agagucauga gcuaccugaa cgccucuuga      660


<210>  81
<211>  657
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  IL12A(1-219) CDS mRNA opt5

<400>  81
augugccccg ccagaagccu gcuccuggug gcuacccuug uccugcucga ccaccugucc       60

cuugcccgga accugccugu ugcgacaccg gaucccggca uguucccuug ucuccaucac      120

ucucagaauc ugcugcgcgc ugugagcaac augcuccaaa aggccagaca gacgcuggag      180

uuuuaccccu gcaccuccga agagaucgac caugaagaua uuacaaaaga caagaccucu      240

acaguggagg ccugucuucc ucuggaacuc accaaaaaug agagcugccu gaacucccgg      300

gagacaucuu ucaucaccaa ugggagcugu cuugcuuccc gcaagacgag cuuuaugaug      360

gcccugugcc ucucuuccau uuaugaagau cugaaaaugu accaggucga guucaagacc      420

augaacgcua agcugcucau ggaccccaaa agacagaucu uucuggauca aaauaugcuu      480

gccgugauug acgaacugau gcaggcgcuc aacuucaaua gcgagacagu uccucagaag      540

ucuucccugg aggaaccgga uuuuuauaaa accaagauca aacuuuguau ccugcuccac      600

gccuuccgga uucgcgcugu gacaaucgac agagucauga gcuaccugaa cgccucu         657


<210>  82
<211>  594
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  IL12A(23-219) CDS mRNA opt5

<400>  82
cggaaccugc cuguugcgac accggauccc ggcauguucc cuugucucca ucacucucag       60

aaucugcugc gcgcugugag caacaugcuc caaaaggcca gacagacgcu ggaguuuuac      120

cccugcaccu ccgaagagau cgaccaugaa gauauuacaa aagacaagac cucuacagug      180

gaggccuguc uuccucugga acucaccaaa aaugagagcu gccugaacuc ccgggagaca      240

ucuuucauca ccaaugggag cugucuugcu ucccgcaaga cgagcuuuau gauggcccug      300

ugccucucuu ccauuuauga agaucugaaa auguaccagg ucgaguucaa gaccaugaac      360

gcuaagcugc ucauggaccc caaaagacag aucuuucugg aucaaaauau gcuugccgug      420

auugacgaac ugaugcaggc gcucaacuuc aauagcgaga caguuccuca gaagucuucc      480

cuggaggaac cggauuuuua uaaaaccaag aucaaacuuu guauccugcu ccacgccuuc      540

cggauucgcg cugugacaau cgacagaguc augagcuacc ugaacgccuc uuga            594


<210>  83
<211>  987
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  IL12B CDS mRNA opt5

<400>  83
augugccacc agcaacuggu gaucagcugg uucucccucg ucuuucuggc cucuccccuu       60

guugcuauuu gggagcugaa gaaagacgug uacguggucg aacucgauug guauccugac      120

gccccgggcg agaugguggu ucugaccugu gauacacccg aagaggacgg gaucacgugg      180

acccuugauc agagcuccga agugcuggga ucuggcaaga cacucaccau ucaggucaaa      240

gaguucgggg acgcgggaca guacacaugc cauaagggcg gggaggugcu gagccacucc      300

cugcuccugc uucauaaaaa ggaagaugga aucuggucua ccgacauucu gaaggaucaa      360

aaagagccua agaacaaaac auuucucaga ugugaagcua agaauuauag cggccgguuu      420

accugcuggu ggcugacgac caucuccaca gaccuuaccu ucagcguuaa aucuucccgc      480

ggcagcucug auccccaggg ggugacaugu ggagccgcca cccuguccgc ugagagaguc      540

cggggcgaca acaaggagua cgaauauagc guggagugcc aggaagauuc ugccuguccu      600

gcugccgagg aaucccuccc caucgaggug auggucgacg cgguucacaa gcugaaauac      660

gagaauuaua cgagcuccuu cuuuauucgc gacaucauua agccugaucc gcccaaaaac      720

cugcagcuca agccucugaa aaauucuaga caaguggaag ugagcuggga guaccccgac      780

acauggucca ccccucauag cuacuucucu cuuacauuuu gcguccaggu gcaggggaag      840

uccaaacggg aaaagaagga ucgcguuuuc accgacaaaa ccagcgccac agugaucugu      900

agaaagaacg cuucuauuag cguccgggcc caggaucgcu auuacuccuc uagcuggucc      960

gagugggcua gcgugcccug cucuuga                                          987


<210>  84
<211>  984
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  IL12B(1-328) CDS mRNA opt5

<400>  84
augugccacc agcaacuggu gaucagcugg uucucccucg ucuuucuggc cucuccccuu       60

guugcuauuu gggagcugaa gaaagacgug uacguggucg aacucgauug guauccugac      120

gccccgggcg agaugguggu ucugaccugu gauacacccg aagaggacgg gaucacgugg      180

acccuugauc agagcuccga agugcuggga ucuggcaaga cacucaccau ucaggucaaa      240

gaguucgggg acgcgggaca guacacaugc cauaagggcg gggaggugcu gagccacucc      300

cugcuccugc uucauaaaaa ggaagaugga aucuggucua ccgacauucu gaaggaucaa      360

aaagagccua agaacaaaac auuucucaga ugugaagcua agaauuauag cggccgguuu      420

accugcuggu ggcugacgac caucuccaca gaccuuaccu ucagcguuaa aucuucccgc      480

ggcagcucug auccccaggg ggugacaugu ggagccgcca cccuguccgc ugagagaguc      540

cggggcgaca acaaggagua cgaauauagc guggagugcc aggaagauuc ugccuguccu      600

gcugccgagg aaucccuccc caucgaggug auggucgacg cgguucacaa gcugaaauac      660

gagaauuaua cgagcuccuu cuuuauucgc gacaucauua agccugaucc gcccaaaaac      720

cugcagcuca agccucugaa aaauucuaga caaguggaag ugagcuggga guaccccgac      780

acauggucca ccccucauag cuacuucucu cuuacauuuu gcguccaggu gcaggggaag      840

uccaaacggg aaaagaagga ucgcguuuuc accgacaaaa ccagcgccac agugaucugu      900

agaaagaacg cuucuauuag cguccgggcc caggaucgcu auuacuccuc uagcuggucc      960

gagugggcua gcgugcccug cucu                                             984


<210>  85
<211>  921
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  IL12B(23-328) CDS mRNA opt5

<400>  85
auuugggagc ugaagaaaga cguguacgug gucgaacucg auugguaucc ugacgccccg       60

ggcgagaugg ugguucugac cugugauaca cccgaagagg acgggaucac guggacccuu      120

gaucagagcu ccgaagugcu gggaucuggc aagacacuca ccauucaggu caaagaguuc      180

ggggacgcgg gacaguacac augccauaag ggcggggagg ugcugagcca cucccugcuc      240

cugcuucaua aaaaggaaga uggaaucugg ucuaccgaca uucugaagga ucaaaaagag      300

ccuaagaaca aaacauuucu cagaugugaa gcuaagaauu auagcggccg guuuaccugc      360

ugguggcuga cgaccaucuc cacagaccuu accuucagcg uuaaaucuuc ccgcggcagc      420

ucugaucccc agggggugac auguggagcc gccacccugu ccgcugagag aguccggggc      480

gacaacaagg aguacgaaua uagcguggag ugccaggaag auucugccug uccugcugcc      540

gaggaauccc uccccaucga ggugaugguc gacgcgguuc acaagcugaa auacgagaau      600

uauacgagcu ccuucuuuau ucgcgacauc auuaagccug auccgcccaa aaaccugcag      660

cucaagccuc ugaaaaauuc uagacaagug gaagugagcu gggaguaccc cgacacaugg      720

uccaccccuc auagcuacuu cucucuuaca uuuugcgucc aggugcaggg gaaguccaaa      780

cgggaaaaga aggaucgcgu uuucaccgac aaaaccagcg ccacagugau cuguagaaag      840

aacgcuucua uuagcguccg ggcccaggau cgcuauuacu ccucuagcug guccgagugg      900

gcuagcgugc ccugcucuug a                                                921


<210>  86
<211>  54
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Linker-sFvCC49-218 CDS mRNA opt5

<400>  86
ggcagcaccu ccgggucugg aaagcccggc agcggggagg gauccacaaa aggc             54


<210>  87
<211>  1632
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  IL12 CDS mRNA opt5

<400>  87
augugccacc agcaacuggu gaucagcugg uucucccucg ucuuucuggc cucuccccuu       60

guugcuauuu gggagcugaa gaaagacgug uacguggucg aacucgauug guauccugac      120

gccccgggcg agaugguggu ucugaccugu gauacacccg aagaggacgg gaucacgugg      180

acccuugauc agagcuccga agugcuggga ucuggcaaga cacucaccau ucaggucaaa      240

gaguucgggg acgcgggaca guacacaugc cauaagggcg gggaggugcu gagccacucc      300

cugcuccugc uucauaaaaa ggaagaugga aucuggucua ccgacauucu gaaggaucaa      360

aaagagccua agaacaaaac auuucucaga ugugaagcua agaauuauag cggccgguuu      420

accugcuggu ggcugacgac caucuccaca gaccuuaccu ucagcguuaa aucuucccgc      480

ggcagcucug auccccaggg ggugacaugu ggagccgcca cccuguccgc ugagagaguc      540

cggggcgaca acaaggagua cgaauauagc guggagugcc aggaagauuc ugccuguccu      600

gcugccgagg aaucccuccc caucgaggug auggucgacg cgguucacaa gcugaaauac      660

gagaauuaua cgagcuccuu cuuuauucgc gacaucauua agccugaucc gcccaaaaac      720

cugcagcuca agccucugaa aaauucuaga caaguggaag ugagcuggga guaccccgac      780

acauggucca ccccucauag cuacuucucu cuuacauuuu gcguccaggu gcaggggaag      840

uccaaacggg aaaagaagga ucgcguuuuc accgacaaaa ccagcgccac agugaucugu      900

agaaagaacg cuucuauuag cguccgggcc caggaucgcu auuacuccuc uagcuggucc      960

gagugggcua gcgugcccug cucuggcagc accuccgggu cuggaaagcc cggcagcggg     1020

gagggaucca caaaaggccg gaaccugccu guugcgacac cggaucccgg cauguucccu     1080

ugucuccauc acucucagaa ucugcugcgc gcugugagca acaugcucca aaaggccaga     1140

cagacgcugg aguuuuaccc cugcaccucc gaagagaucg accaugaaga uauuacaaaa     1200

gacaagaccu cuacagugga ggccugucuu ccucuggaac ucaccaaaaa ugagagcugc     1260

cugaacuccc gggagacauc uuucaucacc aaugggagcu gucuugcuuc ccgcaagacg     1320

agcuuuauga uggcccugug ccucucuucc auuuaugaag aucugaaaau guaccagguc     1380

gaguucaaga ccaugaacgc uaagcugcuc auggacccca aaagacagau cuuucuggau     1440

caaaauaugc uugccgugau ugacgaacug augcaggcgc ucaacuucaa uagcgagaca     1500

guuccucaga agucuucccu ggaggaaccg gauuuuuaua aaaccaagau caaacuuugu     1560

auccugcucc acgccuuccg gauucgcgcu gugacaaucg acagagucau gagcuaccug     1620

aacgccucuu ga                                                         1632


<210>  88
<211>  786
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  CD40LG CDS mRNA opt5

<400>  88
augaucgaga ccuacaacca gacaagcccc agauccgccg cuacgggccu gccuauuucu       60

augaagaucu ucauguaucu ccugaccgug uuucuuauua cacaaaugau cgggagcgcc      120

cuguucgcgg ucuaccucca ccggcgccug gacaaaauug aagaugagag aaaucuucau      180

gaagacuuug uuuucaugaa gaccauccag cggugcaaca caggagagcg cucccugucu      240

cuccugaauu gugaagagau caaaagccag uuugagggcu ucgugaagga uauuaugcug      300

aacaaagaag agaccaagaa ggaaaauucc uuugagaugc agaaagggga ccaaaacccg      360

cagaucgcug cccacgugau uucugaggcc agcuccaaga caaccagcgu ccuccagugg      420

gcugaaaaag gauauuacac gaugucuaau aaccugguga cccuugagaa uggcaagcag      480

cugacaguua aaagacaagg gcucuauuac aucuaugccc aggugaccuu cugcuccaac      540

cgggaagcua gcucucaggc ccccuuuauu gcgucccugu gucuuaagag cccuggacgc      600

uucgagagaa uccugcuccg ggccgcuaau acacauucuu ccgccaagcc cugcggccag      660

caaagcauuc accugggcgg ggucuuugaa cugcagccug gagcuuccgu guucguuaac      720

gugaccgauc ccucucaggu cagccauggc acgggguuua cauccuucgg acuccugaaa      780

cuuuga                                                                 786


<210>  89
<211>  867
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  PDCD1 CDS mRNA opt6

<400>  89
augcaaauac cacaagcacc auggccagua guaugggcug uacuacaauu agguuggcga       60

ccaggauggu uuuuagacuc accagaucgu ccauggaacc caccaacauu uucaccagca      120

uuauuaguag uaacagaagg agauaaugca accuuuacau guucauucag uaacacauca      180

gaaaguuuug uacuaaauug guauagaaug ucaccuucaa aucaaacaga uaaauuagca      240

gcauuuccag aagauagauc acaaccagga caagauugca gauuuagagu aacacaauua      300

ccuaauggac gagacuuuca uaugucagua guaagagcuc gacguaacga uucaggaaca      360

uacuuaugug gagcaauauc auuagcacca aaagcacaaa uaaaagaauc uuuaagagca      420

gaauuaagag uaacagaaag acgcgcagaa guaccaacag cacauccaag cccuucacca      480

cgaccugcag gacaauuuca aacauuagua gucggaguag uaggaggauu auuagguuca      540

cugguauuau uaguaugggu auuagcagua auaugcucca gagcagcaag aggaacaaua      600

ggagcaagaa gaacaggaca accauuaaaa gaagacccau cugcaguacc aguauuuuca      660

guugacuaug gagaacuaga uuuccaaugg agggaaaaaa caccagaacc uccaguucca      720

uguguaccag aacaaacaga auaugcaaca auuguauuuc ccucaggaau gggaacaucu      780

aguccagcaa gaagaggauc agcugaugga ccaagaucag cacaaccauu aagaccagaa      840

gauggacauu guucauggcc auuauaa                                          867


<210>  90
<211>  450
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  PDCD1(1-149) CDS mRNA opt6

<400>  90
augcaaauac cacaagcacc auggccagua guaugggcug uacuacaauu agguuggcga       60

ccaggauggu uuuuagacuc accagaucgu ccauggaacc caccaacauu uucaccagca      120

uuauuaguag uaacagaagg agauaaugca accuuuacau guucauucag uaacacauca      180

gaaaguuuug uacuaaauug guauagaaug ucaccuucaa aucaaacaga uaaauuagca      240

gcauuuccag aagauagauc acaaccagga caagauugca gauuuagagu aacacaauua      300

ccuaauggac gagacuuuca uaugucagua guaagagcuc gacguaacga uucaggaaca      360

uacuuaugug gagcaauauc auuagcacca aaagcacaaa uaaaagaauc uuuaagagca      420

gaauuaagag uaacagaaag acgcgcauaa                                       450


<210>  91
<211>  660
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  IL12A CDS mRNA opt6

<400>  91
augugcccag caagaucacu acuacuggua gcaacacugg uacuacuaga ccaccuauca       60

cucgccagaa accucccagu agccacacca gacccaggaa uguuccccug ccuccaccau      120

ucccaaaacc uacuaagagc aguaucaaac augcuacaaa aagcaagaca aacacuagag      180

uucuauccau gcacaucaga agaaauagac cacgaagaca uaacaaaaga caaaacauca      240

accguagaag caugccuccc acucgaacuc acaaaaaacg aaucaugccu aaacucaaga      300

gaaacaucau ucauaacaaa cggcucaugc uuagccucaa gaaaaacauc auucaugaug      360

gcacuaugcc ucucauccau auaugaagac uuaaaaaugu accaaguaga auuuaaaacc      420

augaacgcaa aauuacuaau ggacccaaaa agacaaauau uccuagacca aaacaugcua      480

gcaguaauag acgaacuaau gcaagcacua aacuucaacu cagaaaccgu accccaaaaa      540

ucaucucuag aagaaccaga cuucuacaaa acaaaaauaa aacuaugcau acuacuacac      600

gccuucagaa uaagagccgu cacaauagac agagucaugu cauaccuaaa cgccucauaa      660


<210>  92
<211>  657
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  IL12A(1-219) CDS mRNA opt6

<400>  92
augugcccag caagaucacu acuacuggua gcaacacugg uacuacuaga ccaccuauca       60

cucgccagaa accucccagu agccacacca gacccaggaa uguuccccug ccuccaccau      120

ucccaaaacc uacuaagagc aguaucaaac augcuacaaa aagcaagaca aacacuagag      180

uucuauccau gcacaucaga agaaauagac cacgaagaca uaacaaaaga caaaacauca      240

accguagaag caugccuccc acucgaacuc acaaaaaacg aaucaugccu aaacucaaga      300

gaaacaucau ucauaacaaa cggcucaugc uuagccucaa gaaaaacauc auucaugaug      360

gcacuaugcc ucucauccau auaugaagac uuaaaaaugu accaaguaga auuuaaaacc      420

augaacgcaa aauuacuaau ggacccaaaa agacaaauau uccuagacca aaacaugcua      480

gcaguaauag acgaacuaau gcaagcacua aacuucaacu cagaaaccgu accccaaaaa      540

ucaucucuag aagaaccaga cuucuacaaa acaaaaauaa aacuaugcau acuacuacac      600

gccuucagaa uaagagccgu cacaauagac agagucaugu cauaccuaaa cgccuca         657


<210>  93
<211>  594
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  IL12A(23-219) CDS mRNA opt6

<400>  93
agaaaccucc caguagccac accagaccca ggaauguucc ccugccucca ccauucccaa       60

aaccuacuaa gagcaguauc aaacaugcua caaaaagcaa gacaaacacu agaguucuau      120

ccaugcacau cagaagaaau agaccacgaa gacauaacaa aagacaaaac aucaaccgua      180

gaagcaugcc ucccacucga acucacaaaa aacgaaucau gccuaaacuc aagagaaaca      240

ucauucauaa caaacggcuc augcuuagcc ucaagaaaaa caucauucau gauggcacua      300

ugccucucau ccauauauga agacuuaaaa auguaccaag uagaauuuaa aaccaugaac      360

gcaaaauuac uaauggaccc aaaaagacaa auauuccuag accaaaacau gcuagcagua      420

auagacgaac uaaugcaagc acuaaacuuc aacucagaaa ccguacccca aaaaucaucu      480

cuagaagaac cagacuucua caaaacaaaa auaaaacuau gcauacuacu acacgccuuc      540

agaauaagag ccgucacaau agacagaguc augucauacc uaaacgccuc auaa            594


<210>  94
<211>  987
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  IL12B CDS mRNA opt6

<400>  94
augugccacc aacaacuggu aauaucaugg uucucacugg uauucuuggc aucaccccua       60

guagcaauau gggaacuaaa aaaagacgua uacguaguag aacuagacug guacccagac      120

gcaccaggag aaaugguagu auuaacaugc gacacaccag aagaagaugg aauaacuugg      180

acauuagacc aaucaaguga aguauuagga ucaggcaaaa cacuaacuau acaaguaaaa      240

gaauuuggag acgcaggaca auacacgugc cacaaaggag gcgaaguccu aucacauuca      300

cuacuauuau uacacaaaaa agaagacgga aucuggagca cagacauauu aaaagaccaa      360

aaagaaccaa aaaacaaaac auuucuaaga ugcgaagcua aaaacuauuc aggaagauuc      420

acaugcuggu ggcuaacaac caucaguacc gacuuaacau ucucaguaaa aucaucaaga      480

ggaucaucag acccacaagg aguaacaugu ggagcagcaa cacuaagcgc agaaagagua      540

cgaggagaca acaaagaaua cgaauauuca guagaauguc aagaagacuc agcaugcccu      600

gcagcagaag aaucauuacc aauagaagua auggucgacg cuguacacaa acuaaaauau      660

gaaaauuaca caagcaguuu cuucauaaga gacauaauaa aacccgaccc accaaaaaac      720

cuacaacuaa aaccauuaaa aaauucaaga caaguagaag uaucauggga auacccagau      780

acauggagca caccacacag uuacuucuca uuaacauucu gcguacaagu acaaggaaaa      840

aguaaaagag aaaaaaaaga cagaguauuc acagauaaga cuucagcaac aguaauaugc      900

agaaaaaacg caagcauaag cguacgagca caagacagau auuacucaag cucaugguca      960

gaaugggcau caguaccaug uucauaa                                          987


<210>  95
<211>  984
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  IL12B(1-328) CDS mRNA opt6

<400>  95
augugccacc aacaacuggu aauaucaugg uucucacugg uauucuuggc aucaccccua       60

guagcaauau gggaacuaaa aaaagacgua uacguaguag aacuagacug guacccagac      120

gcaccaggag aaaugguagu auuaacaugc gacacaccag aagaagaugg aauaacuugg      180

acauuagacc aaucaaguga aguauuagga ucaggcaaaa cacuaacuau acaaguaaaa      240

gaauuuggag acgcaggaca auacacgugc cacaaaggag gcgaaguccu aucacauuca      300

cuacuauuau uacacaaaaa agaagacgga aucuggagca cagacauauu aaaagaccaa      360

aaagaaccaa aaaacaaaac auuucuaaga ugcgaagcua aaaacuauuc aggaagauuc      420

acaugcuggu ggcuaacaac caucaguacc gacuuaacau ucucaguaaa aucaucaaga      480

ggaucaucag acccacaagg aguaacaugu ggagcagcaa cacuaagcgc agaaagagua      540

cgaggagaca acaaagaaua cgaauauuca guagaauguc aagaagacuc agcaugcccu      600

gcagcagaag aaucauuacc aauagaagua auggucgacg cuguacacaa acuaaaauau      660

gaaaauuaca caagcaguuu cuucauaaga gacauaauaa aacccgaccc accaaaaaac      720

cuacaacuaa aaccauuaaa aaauucaaga caaguagaag uaucauggga auacccagau      780

acauggagca caccacacag uuacuucuca uuaacauucu gcguacaagu acaaggaaaa      840

aguaaaagag aaaaaaaaga cagaguauuc acagauaaga cuucagcaac aguaauaugc      900

agaaaaaacg caagcauaag cguacgagca caagacagau auuacucaag cucaugguca      960

gaaugggcau caguaccaug uuca                                             984


<210>  96
<211>  921
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  IL12B(23-328) CDS mRNA opt6

<400>  96
auaugggaac uaaaaaaaga cguauacgua guagaacuag acugguaccc agacgcacca       60

ggagaaaugg uaguauuaac augcgacaca ccagaagaag auggaauaac uuggacauua      120

gaccaaucaa gugaaguauu aggaucaggc aaaacacuaa cuauacaagu aaaagaauuu      180

ggagacgcag gacaauacac gugccacaaa ggaggcgaag uccuaucaca uucacuacua      240

uuauuacaca aaaaagaaga cggaaucugg agcacagaca uauuaaaaga ccaaaaagaa      300

ccaaaaaaca aaacauuucu aagaugcgaa gcuaaaaacu auucaggaag auucacaugc      360

ugguggcuaa caaccaucag uaccgacuua acauucucag uaaaaucauc aagaggauca      420

ucagacccac aaggaguaac auguggagca gcaacacuaa gcgcagaaag aguacgagga      480

gacaacaaag aauacgaaua uucaguagaa ugucaagaag acucagcaug cccugcagca      540

gaagaaucau uaccaauaga aguaaugguc gacgcuguac acaaacuaaa auaugaaaau      600

uacacaagca guuucuucau aagagacaua auaaaacccg acccaccaaa aaaccuacaa      660

cuaaaaccau uaaaaaauuc aagacaagua gaaguaucau gggaauaccc agauacaugg      720

agcacaccac acaguuacuu cucauuaaca uucugcguac aaguacaagg aaaaaguaaa      780

agagaaaaaa aagacagagu auucacagau aagacuucag caacaguaau augcagaaaa      840

aacgcaagca uaagcguacg agcacaagac agauauuacu caagcucaug gucagaaugg      900

gcaucaguac cauguucaua a                                                921


<210>  97
<211>  54
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Linker-sFvCC49-218 CDS mRNA opt6

<400>  97
ggaaguacaa guggaagugg aaaaccagga aguggagaag gaaguacaaa agga             54


<210>  98
<211>  1632
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  IL12 CDS mRNA opt6

<400>  98
augugccacc aacaacuggu aauaucaugg uucucacugg uauucuuggc aucaccccua       60

guagcaauau gggaacuaaa aaaagacgua uacguaguag aacuagacug guacccagac      120

gcaccaggag aaaugguagu auuaacaugc gacacaccag aagaagaugg aauaacuugg      180

acauuagacc aaucaaguga aguauuagga ucaggcaaaa cacuaacuau acaaguaaaa      240

gaauuuggag acgcaggaca auacacgugc cacaaaggag gcgaaguccu aucacauuca      300

cuacuauuau uacacaaaaa agaagacgga aucuggagca cagacauauu aaaagaccaa      360

aaagaaccaa aaaacaaaac auuucuaaga ugcgaagcua aaaacuauuc aggaagauuc      420

acaugcuggu ggcuaacaac caucaguacc gacuuaacau ucucaguaaa aucaucaaga      480

ggaucaucag acccacaagg aguaacaugu ggagcagcaa cacuaagcgc agaaagagua      540

cgaggagaca acaaagaaua cgaauauuca guagaauguc aagaagacuc agcaugcccu      600

gcagcagaag aaucauuacc aauagaagua auggucgacg cuguacacaa acuaaaauau      660

gaaaauuaca caagcaguuu cuucauaaga gacauaauaa aacccgaccc accaaaaaac      720

cuacaacuaa aaccauuaaa aaauucaaga caaguagaag uaucauggga auacccagau      780

acauggagca caccacacag uuacuucuca uuaacauucu gcguacaagu acaaggaaaa      840

aguaaaagag aaaaaaaaga cagaguauuc acagauaaga cuucagcaac aguaauaugc      900

agaaaaaacg caagcauaag cguacgagca caagacagau auuacucaag cucaugguca      960

gaaugggcau caguaccaug uucaggaagu acaaguggaa guggaaaacc aggaagugga     1020

gaaggaagua caaaaggaag aaaccuccca guagccacac cagacccagg aauguucccc     1080

ugccuccacc auucccaaaa ccuacuaaga gcaguaucaa acaugcuaca aaaagcaaga     1140

caaacacuag aguucuaucc augcacauca gaagaaauag accacgaaga cauaacaaaa     1200

gacaaaacau caaccguaga agcaugccuc ccacucgaac ucacaaaaaa cgaaucaugc     1260

cuaaacucaa gagaaacauc auucauaaca aacggcucau gcuuagccuc aagaaaaaca     1320

ucauucauga uggcacuaug ccucucaucc auauaugaag acuuaaaaau guaccaagua     1380

gaauuuaaaa ccaugaacgc aaaauuacua auggacccaa aaagacaaau auuccuagac     1440

caaaacaugc uagcaguaau agacgaacua augcaagcac uaaacuucaa cucagaaacc     1500

guaccccaaa aaucaucucu agaagaacca gacuucuaca aaacaaaaau aaaacuaugc     1560

auacuacuac acgccuucag aauaagagcc gucacaauag acagagucau gucauaccua     1620

aacgccucau aa                                                         1632


<210>  99
<211>  786
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  CD40LG CDS mRNA opt6

<400>  99
augauagaaa cauauaauca aacaagccca agaucagcag caacaggacu accaauauca       60

augaaaauau ucauguaccu acucacaguc uuccuaauaa cacaaaugau aggaucugcc      120

cuauuugcag uauaccuaca cagaagacua gauaaaauag aagacgaaag aaaccuacau      180

gaagacuucg uauucaugaa aacaauacaa agaugcaaca ccggagaaag aucccuauca      240

cuacuaaacu gcgaagaaau aaaaucacaa uucgaaggau ucguaaaaga cauaaugcua      300

aacaaagaag aaacaaaaaa agaaaacucu uucgaaaugc aaaaaggaga ccaaaaccca      360

caaauagcug cacacgucau aucagaagca ucaucaaaaa caacaucagu acuucaaugg      420

gcagaaaaag gauacuauac aaugucaaac aaucuaguaa cccuagaaaa cggaaaacaa      480

cuaacaguaa aaagacaagg acuauacuau auauacgcac aaguaacauu cugcucaaac      540

agagaagcau caucacaagc accauucauc gcaucacuau gccuaaaauc cccaggaaga      600

uucgaacgaa uccuacuaag agcagcaaac acacacucau cagcaaaacc augcggccaa      660

caaucaauac accuaggagg aguauucgaa cuacaaccag gagcaucagu auucguaaac      720

guaacagacc ccucacaagu aagccacggc acaggauuca caucauuugg acuauuaaaa      780

uuauaa                                                                 786


<210>  100
<211>  867
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  PDCD1 CDS mRNA opt7

<400>  100
augcagaucc cccaagcccc auggccggug gucugggcag ugcugcagcu cggcuggagg       60

cccggguggu uccuggacag cccagaucgg cccuggaacc cacccaccuu uuccccagcc      120

uugcugguag ugacugaggg ugacaaugcg accuucacgu gcaguuuuag caacacuucc      180

gaaaguuucg uccucaauug guaccgcaug agcccgucca accagaccga uaagcuggcc      240

gcauuucccg aggacaggag ccagccaggc caagauuguc gguuccgcgu gacccaguug      300

cccaauggga gggacuuuca cauguccgug guccgggccc gcaggaacga uaguggcacu      360

uaucugugcg gugcaauuag ccucgcccca aaagcgcaga ucaaggaauc ccugcgggcc      420

gagcugcgcg ugaccgaaag gcgggcagag guacccacgg cccauccgag ccccagucca      480

cgccccgccg ggcaguucca aacucucgug gucggcgugg ugggcgggcu guuggguucc      540

cugguccucc uggugugggu acuggcagug auuuguagca gggccgcgcg gggcaccauc      600

ggggcccgca ggacuggcca gccauugaaa gaggaccccu ccgcaguccc aguguuuagu      660

guggauuacg gugaacucga cuuccagugg cgggagaaga ccccggaacc cccagucccc      720

ugcgugccag agcagaccga guaugccacg auuguauuuc ccagcgggau gggcacuucc      780

agcccggcac gcaggggcag ugccgauggg ccacgguccg cccaaccccu gaggcccgaa      840

gacggucacu guagcuggcc acuguga                                          867


<210>  101
<211>  450
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  PDCD1(1-149) CDS mRNA opt7

<400>  101
augcagaucc cccaagcccc auggccggug gucugggcag ugcugcagcu cggcuggagg       60

cccggguggu uccuggacag cccagaucgg cccuggaacc cacccaccuu uuccccagcc      120

uugcugguag ugacugaggg ugacaaugcg accuucacgu gcaguuuuag caacacuucc      180

gaaaguuucg uccucaauug guaccgcaug agcccgucca accagaccga uaagcuggcc      240

gcauuucccg aggacaggag ccagccaggc caagauuguc gguuccgcgu gacccaguug      300

cccaauggga gggacuuuca cauguccgug guccgggccc gcaggaacga uaguggcacu      360

uaucugugcg gugcaauuag ccucgcccca aaagcgcaga ucaaggaauc ccugcgggcc      420

gagcugcgcg ugaccgaaag gcgggcauga                                       450


<210>  102
<211>  660
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  IL12A CDS mRNA opt7

<400>  102
augugccccg ccaggagccu gcuccuggug gcaaccuugg uccugcucga ccaccugucc       60

uuggcccgga accugccagu ggcgacuccg gaucccggca uguucccaug ucuccaucac      120

agucagaauc ugcugcgcgc cguaagcaac augcuccaaa aggcaaggca gacccuggag      180

uuuuaccccu gcacguccga agagaucgac caugaagaua uuacuaaaga caagaccagu      240

accguggagg ccuguuugcc acuggaacuc acuaaaaaug agagcugccu gaacucccgg      300

gagaccagcu ucaucacgaa uggguccugu cuggcaaguc gcaagacuag cuuuaugaug      360

gccuugugcc ucuccagcau uuaugaagau cugaaaaugu accaggucga guucaagacc      420

augaacgcga agcugcucau ggaccccaaa aggcagaucu uucuggauca aaauauguug      480

gccgugauug acgaacugau gcaggcacuc aacuucaaua gugagacugu gccacagaag      540

uccagccugg aggaaccgga uuuuuauaaa accaagauca aacuguguau cuugcuccac      600

gccuuccgga uucgcgccgu caccaucgac agggugaugu ccuaccugaa cgcaaguuga      660


<210>  103
<211>  657
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  IL12A(1-219) CDS mRNA opt7

<400>  103
augugccccg ccaggagccu gcuccuggug gcaaccuugg uccugcucga ccaccugucc       60

uuggcccgga accugccagu ggcgacuccg gaucccggca uguucccaug ucuccaucac      120

agucagaauc ugcugcgcgc cguaagcaac augcuccaaa aggcaaggca gacccuggag      180

uuuuaccccu gcacguccga agagaucgac caugaagaua uuacuaaaga caagaccagu      240

accguggagg ccuguuugcc acuggaacuc acuaaaaaug agagcugccu gaacucccgg      300

gagaccagcu ucaucacgaa uggguccugu cuggcaaguc gcaagacuag cuuuaugaug      360

gccuugugcc ucuccagcau uuaugaagau cugaaaaugu accaggucga guucaagacc      420

augaacgcga agcugcucau ggaccccaaa aggcagaucu uucuggauca aaauauguug      480

gccgugauug acgaacugau gcaggcacuc aacuucaaua gugagacugu gccacagaag      540

uccagccugg aggaaccgga uuuuuauaaa accaagauca aacuguguau cuugcuccac      600

gccuuccgga uucgcgccgu caccaucgac agggugaugu ccuaccugaa cgcaagu         657


<210>  104
<211>  594
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  IL12A(23-219) CDS mRNA opt7

<400>  104
cggaaccugc caguggcgac uccggauccc ggcauguucc caugucucca ucacagucag       60

aaucugcugc gcgccguaag caacaugcuc caaaaggcaa ggcagacccu ggaguuuuac      120

cccugcacgu ccgaagagau cgaccaugaa gauauuacua aagacaagac caguaccgug      180

gaggccuguu ugccacugga acucacuaaa aaugagagcu gccugaacuc ccgggagacc      240

agcuucauca cgaauggguc cugucuggca agucgcaaga cuagcuuuau gauggccuug      300

ugccucucca gcauuuauga agaucugaaa auguaccagg ucgaguucaa gaccaugaac      360

gcgaagcugc ucauggaccc caaaaggcag aucuuucugg aucaaaauau guuggccgug      420

auugacgaac ugaugcaggc acucaacuuc aauagugaga cugugccaca gaaguccagc      480

cuggaggaac cggauuuuua uaaaaccaag aucaaacugu guaucuugcu ccacgccuuc      540

cggauucgcg ccgucaccau cgacagggug auguccuacc ugaacgcaag uuga            594


<210>  105
<211>  987
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  IL12B CDS mRNA opt7

<400>  105
augugccacc agcaacuggu gaucagcugg uucucccucg ucuuucuggc cagucccuug       60

guggcaauuu gggagcugaa gaaagacgua uacguggucg aacucgauug guauccagac      120

gccccgggcg agaugguggu gcugaccugu gauacucccg aagaggacgg gaucaccugg      180

acguuggauc agagcuccga aguccugggu aguggcaaga cucucaccau ucaggugaaa      240

gaguucgggg acgcgggcca guauaccugc cauaagggug gggagguacu gagccacucc      300

cugcuccugu ugcauaaaaa ggaagauggc aucuggagca cugacauucu gaaggaucaa      360

aaagagccaa agaacaaaac cuuucucagg ugugaagcca agaauuacuc cggccgguuc      420

acgugcuggu ggcugacuac caucaguacu gaccugaccu uuagcgugaa auccagccgc      480

gggaguuccg auccccaggg ugucaccugu ggcgcagcca cguugagcgc agagagggug      540

cgcggggaca acaaggagua cgaauauucc guggagugcc aggaagauag ugccugucca      600

gcggccgagg aaagccuccc caucgagguc augguggacg caguacacaa acugaaguac      660

gagaauuaua cuuccagcuu cuuuauucgg gacaucauua agccagaucc gcccaaaaac      720

cugcagcuca agccacugaa aaauaguagg caaguggaag ucuccuggga guaccccgac      780

accuggagca cuccacauag uuacuucucc uugaccuuuu gcguccaggu gcagggcaag      840

agcaaacggg aaaagaagga ucgcguguuc accgacaaaa cuagcgccac ggugaucugu      900

aggaagaacg ccuccauuag uguacgggca caggaucgcu auuacagcuc cagcuggagu      960

gagugggccu ccgugcccug cagcuga                                          987


<210>  106
<211>  984
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  IL12B(1-328) CDS mRNA opt7

<400>  106
augugccacc agcaacuggu gaucagcugg uucucccucg ucuuucuggc cagucccuug       60

guggcaauuu gggagcugaa gaaagacgua uacguggucg aacucgauug guauccagac      120

gccccgggcg agaugguggu gcugaccugu gauacucccg aagaggacgg gaucaccugg      180

acguuggauc agagcuccga aguccugggu aguggcaaga cucucaccau ucaggugaaa      240

gaguucgggg acgcgggcca guauaccugc cauaagggug gggagguacu gagccacucc      300

cugcuccugu ugcauaaaaa ggaagauggc aucuggagca cugacauucu gaaggaucaa      360

aaagagccaa agaacaaaac cuuucucagg ugugaagcca agaauuacuc cggccgguuc      420

acgugcuggu ggcugacuac caucaguacu gaccugaccu uuagcgugaa auccagccgc      480

gggaguuccg auccccaggg ugucaccugu ggcgcagcca cguugagcgc agagagggug      540

cgcggggaca acaaggagua cgaauauucc guggagugcc aggaagauag ugccugucca      600

gcggccgagg aaagccuccc caucgagguc augguggacg caguacacaa acugaaguac      660

gagaauuaua cuuccagcuu cuuuauucgg gacaucauua agccagaucc gcccaaaaac      720

cugcagcuca agccacugaa aaauaguagg caaguggaag ucuccuggga guaccccgac      780

accuggagca cuccacauag uuacuucucc uugaccuuuu gcguccaggu gcagggcaag      840

agcaaacggg aaaagaagga ucgcguguuc accgacaaaa cuagcgccac ggugaucugu      900

aggaagaacg ccuccauuag uguacgggca caggaucgcu auuacagcuc cagcuggagu      960

gagugggccu ccgugcccug cagc                                             984


<210>  107
<211>  921
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  IL12B(23-328) CDS mRNA opt7

<400>  107
auuugggagc ugaagaaaga cguauacgug gucgaacucg auugguaucc agacgccccg       60

ggcgagaugg uggugcugac cugugauacu cccgaagagg acgggaucac cuggacguug      120

gaucagagcu ccgaaguccu ggguaguggc aagacucuca ccauucaggu gaaagaguuc      180

ggggacgcgg gccaguauac cugccauaag gguggggagg uacugagcca cucccugcuc      240

cuguugcaua aaaaggaaga uggcaucugg agcacugaca uucugaagga ucaaaaagag      300

ccaaagaaca aaaccuuucu caggugugaa gccaagaauu acuccggccg guucacgugc      360

ugguggcuga cuaccaucag uacugaccug accuuuagcg ugaaauccag ccgcgggagu      420

uccgaucccc agggugucac cuguggcgca gccacguuga gcgcagagag ggugcgcggg      480

gacaacaagg aguacgaaua uuccguggag ugccaggaag auagugccug uccagcggcc      540

gaggaaagcc uccccaucga ggucauggug gacgcaguac acaaacugaa guacgagaau      600

uauacuucca gcuucuuuau ucgggacauc auuaagccag auccgcccaa aaaccugcag      660

cucaagccac ugaaaaauag uaggcaagug gaagucuccu gggaguaccc cgacaccugg      720

agcacuccac auaguuacuu cuccuugacc uuuugcgucc aggugcaggg caagagcaaa      780

cgggaaaaga aggaucgcgu guucaccgac aaaacuagcg ccacggugau cuguaggaag      840

aacgccucca uuaguguacg ggcacaggau cgcuauuaca gcuccagcug gagugagugg      900

gccuccgugc ccugcagcug a                                                921


<210>  108
<211>  54
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Linker-sFvCC49-218 CDS mRNA opt7

<400>  108
ggcagcaccu ccgggagugg uaagcccggc agcggggagg gcuccacuaa aggu             54


<210>  109
<211>  1632
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  IL12 CDS mRNA opt7

<400>  109
augugccacc agcaacuggu gaucagcugg uucucccucg ucuuucuggc cagucccuug       60

guggcaauuu gggagcugaa gaaagacgua uacguggucg aacucgauug guauccagac      120

gccccgggcg agaugguggu gcugaccugu gauacucccg aagaggacgg gaucaccugg      180

acguuggauc agagcuccga aguccugggu aguggcaaga cucucaccau ucaggugaaa      240

gaguucgggg acgcgggcca guauaccugc cauaagggug gggagguacu gagccacucc      300

cugcuccugu ugcauaaaaa ggaagauggc aucuggagca cugacauucu gaaggaucaa      360

aaagagccaa agaacaaaac cuuucucagg ugugaagcca agaauuacuc cggccgguuc      420

acgugcuggu ggcugacuac caucaguacu gaccugaccu uuagcgugaa auccagccgc      480

gggaguuccg auccccaggg ugucaccugu ggcgcagcca cguugagcgc agagagggug      540

cgcggggaca acaaggagua cgaauauucc guggagugcc aggaagauag ugccugucca      600

gcggccgagg aaagccuccc caucgagguc augguggacg caguacacaa acugaaguac      660

gagaauuaua cuuccagcuu cuuuauucgg gacaucauua agccagaucc gcccaaaaac      720

cugcagcuca agccacugaa aaauaguagg caaguggaag ucuccuggga guaccccgac      780

accuggagca cuccacauag uuacuucucc uugaccuuuu gcguccaggu gcagggcaag      840

agcaaacggg aaaagaagga ucgcguguuc accgacaaaa cuagcgccac ggugaucugu      900

aggaagaacg ccuccauuag uguacgggca caggaucgcu auuacagcuc cagcuggagu      960

gagugggccu ccgugcccug cagcggcagc accuccggga gugguaagcc cggcagcggg     1020

gagggcucca cuaaaggucg gaaccugcca guggcgacuc cggaucccgg cauguuccca     1080

ugucuccauc acagucagaa ucugcugcgc gccguaagca acaugcucca aaaggcaagg     1140

cagacccugg aguuuuaccc cugcacgucc gaagagaucg accaugaaga uauuacuaaa     1200

gacaagacca guaccgugga ggccuguuug ccacuggaac ucacuaaaaa ugagagcugc     1260

cugaacuccc gggagaccag cuucaucacg aauggguccu gucuggcaag ucgcaagacu     1320

agcuuuauga uggccuugug ccucuccagc auuuaugaag aucugaaaau guaccagguc     1380

gaguucaaga ccaugaacgc gaagcugcuc auggacccca aaaggcagau cuuucuggau     1440

caaaauaugu uggccgugau ugacgaacug augcaggcac ucaacuucaa uagugagacu     1500

gugccacaga aguccagccu ggaggaaccg gauuuuuaua aaaccaagau caaacugugu     1560

aucuugcucc acgccuuccg gauucgcgcc gucaccaucg acagggugau guccuaccug     1620

aacgcaaguu ga                                                         1632


<210>  110
<211>  786
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  CD40LG CDS mRNA opt7

<400>  110
augaucgaga ccuacaacca gacuagcccc agguccgccg caaccggccu gccaauuagu       60

augaagaucu ucauguaucu ccugacggug uuuuugauua cucaaaugau cgggagcgcc      120

cuguucgcgg ucuaccucca ccggcgccug gacaaaauug aagaugagag gaauuugcau      180

gaagacuuug uguucaugaa gaccauccag cggugcaaca ccggugagcg cucccugagu      240

cuccugaauu gugaagagau caaaagccag uuugagggcu ucguaaagga uauuaugcug      300

aacaaagaag agacuaagaa ggaaaauucc uuugagaugc agaaagggga ccaaaacccg      360

cagaucgccg cacacgugau uagcgaggcc uccaguaaga ccacgagcgu ccuccagugg      420

gcagaaaaag gcuauuacac uauguccaau aaccugguga ccuuggagaa ugguaagcag      480

cugacuguga aaaggcaagg gcucuauuac aucuaugccc aggucaccuu cugcagcaac      540

cgggaagcga guucccaggc ccccuuuauu gcaagccugu gucugaaguc cccaggccgc      600

uucgagagga ucuugcuccg ggccgccaau acccauagua gcgcaaaacc cugcggccag      660

caauccauuc accucggggg uguguuugaa cugcagccag gcgccagcgu auucgugaac      720

gucacggauc ccagucaggu gucccauggg acuggcuuca ccagcuuugg ucugcugaag      780

uuguga                                                                 786


<210>  111
<211>  867
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  PDCD1 CDS mRNA opt8

<400>  111
augcaaaucc cacaagcccc cuggcccgua gucugggccg uacuacaacu aggcuggaga       60

cccggcuggu uucucgacag ccccgaccga cccuggaacc cccccaccuu cucacccgcc      120

cuccucgucg ucaccgaagg cgacaacgcc acauucacau gcuccuucuc caacaccucu      180

gaaucauucg uccuaaacug guaccgaaug ucacccucca accaaacuga caaacucgcc      240

gccuuucccg aagaccgcuc ccaacccggc caagacugcc gauuccgagu cacacaacuu      300

ccuaacggca gagacuucca cauguccgua guccgagccc gccgaaacga cuccggaacc      360

uaccucugcg gagccaucuc ccucgccccc aaagcccaaa ucaaagaauc ccuccgagca      420

gaacuccgcg ucaccgaacg ccgcgccgaa guccccaccg cacacccauc acccuccccc      480

cgccccgccg gccaauucca aacacuugua guaggcgucg ucggcggccu ccuuggauca      540

cucguccuac uuguaugggu ccuagccguc aucugcucuc gcgccgcacg cggcaccauc      600

ggcgcacgac gaaccggcca accucuaaaa gaagaccccu ccgcaguccc cgucuucucc      660

gucgacuacg gcgaacucga cuuccaaugg cgcgaaaaaa cccccgaacc cccagucccc      720

ugcguacccg aacaaaccga auacgcaaca aucguauucc ccucaggaau gggcaccuca      780

ucccccgccc gacgaggauc agccgacggc ccacgauccg cccaaccccu ccgaccagaa      840

gacggccacu gcucauggcc ccuuuaa                                          867


<210>  112
<211>  450
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  PDCD1(1-149) CDS mRNA opt8

<400>  112
augcaaaucc cacaagcccc cuggcccgua gucugggccg uacuacaacu aggcuggaga       60

cccggcuggu uucucgacag ccccgaccga cccuggaacc cccccaccuu cucacccgcc      120

cuccucgucg ucaccgaagg cgacaacgcc acauucacau gcuccuucuc caacaccucu      180

gaaucauucg uccuaaacug guaccgaaug ucacccucca accaaacuga caaacucgcc      240

gccuuucccg aagaccgcuc ccaacccggc caagacugcc gauuccgagu cacacaacuu      300

ccuaacggca gagacuucca cauguccgua guccgagccc gccgaaacga cuccggaacc      360

uaccucugcg gagccaucuc ccucgccccc aaagcccaaa ucaaagaauc ccuccgagca      420

gaacuccgcg ucaccgaacg ccgcgccuaa                                       450


<210>  113
<211>  660
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  IL12A CDS mRNA opt8

<400>  113
augugccccg ccagaucccu ccuacucguc gcaacacuug uccuccucga ccaccucucc       60

cucgcccgca aucuccccgu cgccaccccc gaccccggaa uguuucccug ccuccaccac      120

ucacaaaacc uccuacgcgc cgucucaaac augcuucaaa aagcccgaca aacccucgaa      180

uuuuaccccu gcaccuccga agaaaucgac cacgaagaca uaaccaaaga caaaaccucc      240

accgucgaag ccugccuacc auuagaacua accaaaaacg aauccugccu caacucacgc      300

gaaaccuccu ucaucacaaa cggcucaugc cucgccucac gcaaaaccuc cuucaugaug      360

gcccucugcc uaucaucaau cuaugaagac cucaaaaugu accaaguaga auuuaaaacc      420

augaacgcca aacuccucau ggaccccaaa cgccaaaucu uccucgacca aaacaugcuc      480

gcagucaucg acgaacucau gcaagcccuc aacuucaacu cagaaacagu cccacaaaaa      540

uccucccucg aagaacccga cuucuauaaa accaaaauca aacucugcau ccuccuccac      600

gccuuccgca uacgcgccgu aaccaucgac cgcguaaugu cauaccuaaa ugccucuuaa      660


<210>  114
<211>  657
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  IL12A(1-219) CDS mRNA opt8

<400>  114
augugccccg ccagaucccu ccuacucguc gcaacacuug uccuccucga ccaccucucc       60

cucgcccgca aucuccccgu cgccaccccc gaccccggaa uguuucccug ccuccaccac      120

ucacaaaacc uccuacgcgc cgucucaaac augcuucaaa aagcccgaca aacccucgaa      180

uuuuaccccu gcaccuccga agaaaucgac cacgaagaca uaaccaaaga caaaaccucc      240

accgucgaag ccugccuacc auuagaacua accaaaaacg aauccugccu caacucacgc      300

gaaaccuccu ucaucacaaa cggcucaugc cucgccucac gcaaaaccuc cuucaugaug      360

gcccucugcc uaucaucaau cuaugaagac cucaaaaugu accaaguaga auuuaaaacc      420

augaacgcca aacuccucau ggaccccaaa cgccaaaucu uccucgacca aaacaugcuc      480

gcagucaucg acgaacucau gcaagcccuc aacuucaacu cagaaacagu cccacaaaaa      540

uccucccucg aagaacccga cuucuauaaa accaaaauca aacucugcau ccuccuccac      600

gccuuccgca uacgcgccgu aaccaucgac cgcguaaugu cauaccuaaa ugccucu         657


<210>  115
<211>  594
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  IL12A(23-219) CDS mRNA opt8

<400>  115
cgcaaucucc ccgucgccac ccccgacccc ggaauguuuc ccugccucca ccacucacaa       60

aaccuccuac gcgccgucuc aaacaugcuu caaaaagccc gacaaacccu cgaauuuuac      120

cccugcaccu ccgaagaaau cgaccacgaa gacauaacca aagacaaaac cuccaccguc      180

gaagccugcc uaccauuaga acuaaccaaa aacgaauccu gccucaacuc acgcgaaacc      240

uccuucauca caaacggcuc augccucgcc ucacgcaaaa ccuccuucau gauggcccuc      300

ugccuaucau caaucuauga agaccucaaa auguaccaag uagaauuuaa aaccaugaac      360

gccaaacucc ucauggaccc caaacgccaa aucuuccucg accaaaacau gcucgcaguc      420

aucgacgaac ucaugcaagc ccucaacuuc aacucagaaa cagucccaca aaaauccucc      480

cucgaagaac ccgacuucua uaaaaccaaa aucaaacucu gcauccuccu ccacgccuuc      540

cgcauacgcg ccguaaccau cgaccgcgua augucauacc uaaaugccuc uuaa            594


<210>  116
<211>  987
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  IL12B CDS mRNA opt8

<400>  116
augugccacc aacaacucgu cauaagcugg uucagccuag uauuccucgc cucaccccuc       60

gucgccaucu gggaacucaa gaaagacgua uacgucgucg aacuagacug guaccccgac      120

gcacccggag aaaugguagu acucacaugc gacacccccg aagaagacgg caucacaugg      180

accuuagacc aaucaucaga aguccucgga uccggaaaaa cccucacaau ccaagucaaa      240

gaguucggcg acgccggcca auacacaugc cacaaaggcg gagaaguccu cucacacuca      300

cuccuucuac uacacaagaa agaagacggc aucuggucca ccgacauacu caaagaccaa      360

aaagaaccca aaaacaaaac cuuccuccgc ugcgaagcca aaaacuacuc cggccgauuc      420

acaugcuggu ggcucaccac caucuccacc gaccugaccu ucuccgucaa auccagcagg      480

ggcuccucag acccacaagg cguaaccugc ggcgcagcca cccuaucggc cgaacgaguc      540

cgcggagaca acaaagaaua cgaauacagc gucgaaugcc aagaagacuc agcaugccca      600

gcagccgaag aaucacuccc caucgaaguc auggucgacg ccguccacaa acuaaaauac      660

gaaaacuaca caagcucauu cuucauccgc gacauaauca aacccgaccc accgaaaaac      720

cuccaacuca aaccccuuaa aaacagccgc caagucgaag ucuccuggga auaccccgac      780

accuggucca caccccacuc cuacuucuca cucaccuucu gcguccaagu ccaaggcaaa      840

uccaaacgcg aaaagaaaga ccgcguauuc accgacaaaa ccuccgccac agucaucugc      900

cgcaaaaacg ccucaaucuc cguccgcgcc caagaccgau acuacagcuc cuccugguca      960

gaaugggccu ccgucccaug cuccuaa                                          987


<210>  117
<211>  984
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  IL12B(1-328) CDS mRNA opt8

<400>  117
augugccacc aacaacucgu cauaagcugg uucagccuag uauuccucgc cucaccccuc       60

gucgccaucu gggaacucaa gaaagacgua uacgucgucg aacuagacug guaccccgac      120

gcacccggag aaaugguagu acucacaugc gacacccccg aagaagacgg caucacaugg      180

accuuagacc aaucaucaga aguccucgga uccggaaaaa cccucacaau ccaagucaaa      240

gaguucggcg acgccggcca auacacaugc cacaaaggcg gagaaguccu cucacacuca      300

cuccuucuac uacacaagaa agaagacggc aucuggucca ccgacauacu caaagaccaa      360

aaagaaccca aaaacaaaac cuuccuccgc ugcgaagcca aaaacuacuc cggccgauuc      420

acaugcuggu ggcucaccac caucuccacc gaccugaccu ucuccgucaa auccagcagg      480

ggcuccucag acccacaagg cguaaccugc ggcgcagcca cccuaucggc cgaacgaguc      540

cgcggagaca acaaagaaua cgaauacagc gucgaaugcc aagaagacuc agcaugccca      600

gcagccgaag aaucacuccc caucgaaguc auggucgacg ccguccacaa acuaaaauac      660

gaaaacuaca caagcucauu cuucauccgc gacauaauca aacccgaccc accgaaaaac      720

cuccaacuca aaccccuuaa aaacagccgc caagucgaag ucuccuggga auaccccgac      780

accuggucca caccccacuc cuacuucuca cucaccuucu gcguccaagu ccaaggcaaa      840

uccaaacgcg aaaagaaaga ccgcguauuc accgacaaaa ccuccgccac agucaucugc      900

cgcaaaaacg ccucaaucuc cguccgcgcc caagaccgau acuacagcuc cuccugguca      960

gaaugggccu ccgucccaug cucc                                             984


<210>  118
<211>  921
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  IL12B(23-328) CDS mRNA opt8

<400>  118
aucugggaac ucaagaaaga cguauacguc gucgaacuag acugguaccc cgacgcaccc       60

ggagaaaugg uaguacucac augcgacacc cccgaagaag acggcaucac auggaccuua      120

gaccaaucau cagaaguccu cggauccgga aaaacccuca caauccaagu caaagaguuc      180

ggcgacgccg gccaauacac augccacaaa ggcggagaag uccucucaca cucacuccuu      240

cuacuacaca agaaagaaga cggcaucugg uccaccgaca uacucaaaga ccaaaaagaa      300

cccaaaaaca aaaccuuccu ccgcugcgaa gccaaaaacu acuccggccg auucacaugc      360

ugguggcuca ccaccaucuc caccgaccug accuucuccg ucaaauccag caggggcucc      420

ucagacccac aaggcguaac cugcggcgca gccacccuau cggccgaacg aguccgcgga      480

gacaacaaag aauacgaaua cagcgucgaa ugccaagaag acucagcaug cccagcagcc      540

gaagaaucac uccccaucga agucaugguc gacgccgucc acaaacuaaa auacgaaaac      600

uacacaagcu cauucuucau ccgcgacaua aucaaacccg acccaccgaa aaaccuccaa      660

cucaaacccc uuaaaaacag ccgccaaguc gaagucuccu gggaauaccc cgacaccugg      720

uccacacccc acuccuacuu cucacucacc uucugcgucc aaguccaagg caaauccaaa      780

cgcgaaaaga aagaccgcgu auucaccgac aaaaccuccg ccacagucau cugccgcaaa      840

aacgccucaa ucuccguccg cgcccaagac cgauacuaca gcuccuccug gucagaaugg      900

gccuccgucc caugcuccua a                                                921


<210>  119
<211>  54
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Linker-sFvCC49-218 CDS mRNA opt8

<400>  119
gggagcacga gcgggagcgg gaagccggga aguggagagg gaaguacaaa ggga             54


<210>  120
<211>  1632
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  IL12 CDS mRNA opt8

<400>  120
augugccacc aacaacucgu cauaagcugg uucagccuag uauuccucgc cucaccccuc       60

gucgccaucu gggaacucaa gaaagacgua uacgucgucg aacuagacug guaccccgac      120

gcacccggag aaaugguagu acucacaugc gacacccccg aagaagacgg caucacaugg      180

accuuagacc aaucaucaga aguccucgga uccggaaaaa cccucacaau ccaagucaaa      240

gaguucggcg acgccggcca auacacaugc cacaaaggcg gagaaguccu cucacacuca      300

cuccuucuac uacacaagaa agaagacggc aucuggucca ccgacauacu caaagaccaa      360

aaagaaccca aaaacaaaac cuuccuccgc ugcgaagcca aaaacuacuc cggccgauuc      420

acaugcuggu ggcucaccac caucuccacc gaccugaccu ucuccgucaa auccagcagg      480

ggcuccucag acccacaagg cguaaccugc ggcgcagcca cccuaucggc cgaacgaguc      540

cgcggagaca acaaagaaua cgaauacagc gucgaaugcc aagaagacuc agcaugccca      600

gcagccgaag aaucacuccc caucgaaguc auggucgacg ccguccacaa acuaaaauac      660

gaaaacuaca caagcucauu cuucauccgc gacauaauca aacccgaccc accgaaaaac      720

cuccaacuca aaccccuuaa aaacagccgc caagucgaag ucuccuggga auaccccgac      780

accuggucca caccccacuc cuacuucuca cucaccuucu gcguccaagu ccaaggcaaa      840

uccaaacgcg aaaagaaaga ccgcguauuc accgacaaaa ccuccgccac agucaucugc      900

cgcaaaaacg ccucaaucuc cguccgcgcc caagaccgau acuacagcuc cuccugguca      960

gaaugggccu ccgucccaug cuccgggagc acgagcggga gcgggaagcc gggaagugga     1020

gagggaagua caaagggacg caaucucccc gucgccaccc ccgaccccgg aauguuuccc     1080

ugccuccacc acucacaaaa ccuccuacgc gccgucucaa acaugcuuca aaaagcccga     1140

caaacccucg aauuuuaccc cugcaccucc gaagaaaucg accacgaaga cauaaccaaa     1200

gacaaaaccu ccaccgucga agccugccua ccauuagaac uaaccaaaaa cgaauccugc     1260

cucaacucac gcgaaaccuc cuucaucaca aacggcucau gccucgccuc acgcaaaacc     1320

uccuucauga uggcccucug ccuaucauca aucuaugaag accucaaaau guaccaagua     1380

gaauuuaaaa ccaugaacgc caaacuccuc auggacccca aacgccaaau cuuccucgac     1440

caaaacaugc ucgcagucau cgacgaacuc augcaagccc ucaacuucaa cucagaaaca     1500

gucccacaaa aauccucccu cgaagaaccc gacuucuaua aaaccaaaau caaacucugc     1560

auccuccucc acgccuuccg cauacgcgcc guaaccaucg accgcguaau gucauaccua     1620

aaugccucuu aa                                                         1632


<210>  121
<211>  786
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  CD40LG CDS mRNA opt8

<400>  121
augauagaaa ccuacaacca aaccucuccc cgauccgcag ccaccggccu ccccaucucc       60

augaaaaucu ucauguaccu ccuaaccguc uuccuaauca cucaaaugau cggcuccgcu      120

cucuucgcag ucuaccucca ccgccgccua gacaaaaucg aagacgaacg caaccuacac      180

gaagacuucg ucuucaugaa aaccauucaa cgcugcaaca caggcgaacg aucccuaucc      240

cuacucaacu gcgaagaaau caaaucccaa uucgaaggcu uuguaaaaga caucaugcuc      300

aacaaagaag aaaccaaaaa agaaaacucc uucgaaaugc aaaaaggcga ccaaaacccc      360

caaauagccg cccaugucau aucagaagcc uccuccaaaa ccaccuccgu ccuccaaugg      420

gccgaaaaag gcuacuacac cauguccaac aaccuaguaa cccuugaaaa cggcaaacaa      480

cucaccguaa aacgccaagg ccucuacuac aucuacgccc aagucaccuu cugcuccaac      540

agagaagcau ccucccaagc acccuucauc gccucccuau gccucaaauc ccccggccgc      600

uucgaacgaa uccuccuccg cgccgccaac acucacuccu cagccaaacc cugcggccaa      660

caaaguauac accuuggcgg agucuucgaa cuccaacccg gcgccuccgu cuucguaaac      720

gucaccgacc ccucacaagu cucccacgga accggauuca ccuccuucgg ccuacuaaaa      780

cuauag                                                                 786


<210>  122
<211>  867
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  PDCD1 CDS mRNA opt9

<400>  122
augcaaaucc cccaagcccc auggcccguc gucugggccg uccuccaacu cggcuggcgc       60

cccggauggu uccuagacuc uccagaccgc cccuggaauc cacccaccuu cucccccgcc      120

cuccuagucg ucaccgaagg cgacaacgcc accuucaccu guucauucuc caacaccuca      180

gaauccuucg uacucaacug guaccgcaug uccccaagca accaaacaga caaacucgcc      240

gccuuccccg aagaccgcuc ccaacccggu caagacugcc gauuccgcgu cacccaacuc      300

cccaacggac gcgacuucca cauguccguc guucgagcac gacgcaacga cucaggcaca      360

uaccuaugcg gagccaucuc ccuagccccc aaagcccaaa ucaaagaauc acuacgcgcc      420

gaacuccgcg ucaccgaacg ccgcgccgaa guacccacag cccacccauc cccaucacca      480

cgcccagcag gucaauucca aaccuuaguc gucggagucg ucggcggccu ccuaggcuca      540

cucguccucc uagucugggu ccucgccguc auaugcagcc gcgccgcacg cggcaccauc      600

ggcgccagac gcaccggaca accccucaaa gaagaccccu cagccguccc cgucuuuucc      660

gucgacuacg gcgaacuaga cuuccaaugg cgcgaaaaaa cccccgaacc ccccguccca      720

ugcguacccg aacaaaccga auacgccaca auagucuucc cauccggcau gggaaccuca      780

ucacccgcca gacgaggcuc agcagauggc ccccgcuccg cacaaccacu ccgaccagaa      840

gacggccacu gcagcuggcc ccuguaa                                          867


<210>  123
<211>  450
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  PDCD1(1-149) CDS mRNA opt9

<400>  123
augcaaaucc cccaagcccc auggcccguc gucugggccg uccuccaacu cggcuggcgc       60

cccggauggu uccuagacuc uccagaccgc cccuggaauc cacccaccuu cucccccgcc      120

cuccuagucg ucaccgaagg cgacaacgcc accuucaccu guucauucuc caacaccuca      180

gaauccuucg uacucaacug guaccgcaug uccccaagca accaaacaga caaacucgcc      240

gccuuccccg aagaccgcuc ccaacccggu caagacugcc gauuccgcgu cacccaacuc      300

cccaacggac gcgacuucca cauguccguc guucgagcac gacgcaacga cucaggcaca      360

uaccuaugcg gagccaucuc ccuagccccc aaagcccaaa ucaaagaauc acuacgcgcc      420

gaacuccgcg ucaccgaacg ccgcgccuaa                                       450


<210>  124
<211>  660
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  IL12A CDS mRNA opt9

<400>  124
augugccccg ccagaucccu ccuccucguc gcaacccucg uccuccucga ccaccucucc       60

cuagcacgua accucccagu cgccacccca gaccccggaa uguuccccug ccuccaucac      120

ucccaaaauc uccuccgugc cgucuccaac augcuccaaa aagcccgcca aacccucgaa      180

uuuuauccau gcaccuccga agaaauagac caugaagaca ucaccaaaga caaaacaucc      240

accgucgaag ccugccuccc ccucgaacuc acaaaaaacg aaucaugccu caacucccgc      300

gaaaccuccu ucauaaccaa cggcucaugc cucgccucuc gcaaaaccuc auucaugaug      360

gcccucugcc uauccucuau cuacgaagac cucaaaaugu accaagucga auuuaaaacc      420

augaacgcca aacuccucau ggaccccaaa cgccaaaucu uccucgacca aaacaugcuc      480

gcagucaucg acgaacucau gcaagcacuc aacuucaacu cagaaaccgu cccccaaaaa      540

uccucccucg aagaacccga cuucuacaaa acaaaaauaa aacucugcau ccuccuccac      600

gccuuccgca uccgagcagu caccaucgau cgcgucaugu ccuaccuaaa cgccuccuaa      660


<210>  125
<211>  657
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  IL12A(1-219) CDS mRNA opt9

<400>  125
augugccccg ccagaucccu ccuccucguc gcaacccucg uccuccucga ccaccucucc       60

cuagcacgua accucccagu cgccacccca gaccccggaa uguuccccug ccuccaucac      120

ucccaaaauc uccuccgugc cgucuccaac augcuccaaa aagcccgcca aacccucgaa      180

uuuuauccau gcaccuccga agaaauagac caugaagaca ucaccaaaga caaaacaucc      240

accgucgaag ccugccuccc ccucgaacuc acaaaaaacg aaucaugccu caacucccgc      300

gaaaccuccu ucauaaccaa cggcucaugc cucgccucuc gcaaaaccuc auucaugaug      360

gcccucugcc uauccucuau cuacgaagac cucaaaaugu accaagucga auuuaaaacc      420

augaacgcca aacuccucau ggaccccaaa cgccaaaucu uccucgacca aaacaugcuc      480

gcagucaucg acgaacucau gcaagcacuc aacuucaacu cagaaaccgu cccccaaaaa      540

uccucccucg aagaacccga cuucuacaaa acaaaaauaa aacucugcau ccuccuccac      600

gccuuccgca uccgagcagu caccaucgau cgcgucaugu ccuaccuaaa cgccucc         657


<210>  126
<211>  594
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  IL12A(23-219) CDS mRNA opt9

<400>  126
cguaaccucc cagucgccac cccagacccc ggaauguucc ccugccucca ucacucccaa       60

aaucuccucc gugccgucuc caacaugcuc caaaaagccc gccaaacccu cgaauuuuau      120

ccaugcaccu ccgaagaaau agaccaugaa gacaucacca aagacaaaac auccaccguc      180

gaagccugcc ucccccucga acucacaaaa aacgaaucau gccucaacuc ccgcgaaacc      240

uccuucauaa ccaacggcuc augccucgcc ucucgcaaaa ccucauucau gauggcccuc      300

ugccuauccu cuaucuacga agaccucaaa auguaccaag ucgaauuuaa aaccaugaac      360

gccaaacucc ucauggaccc caaacgccaa aucuuccucg accaaaacau gcucgcaguc      420

aucgacgaac ucaugcaagc acucaacuuc aacucagaaa ccguccccca aaaauccucc      480

cucgaagaac ccgacuucua caaaacaaaa auaaaacucu gcauccuccu ccacgccuuc      540

cgcauccgag cagucaccau cgaucgcguc auguccuacc uaaacgccuc cuaa            594


<210>  127
<211>  987
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  IL12B CDS mRNA opt9

<400>  127
augugucacc aacaacuugu aaucagcugg uucucccucg ucuuccucgc cucaccccuc       60

gucgccaucu gggaacucaa aaaagacguc uacguagucg aacucgacug guaccccgac      120

gccccaggag aaauggucgu acucaccugu gacacccccg aagaagacgg caucaccugg      180

acccucgacc aauccuccga aguccucggu ucaggaaaaa cccucaccau ccaaguaaaa      240

gaauuuggcg acgccgggca auauaccugc cacaaaggcg gcgagguccu aucccacuca      300

cuccuccucc uccacaagaa agaagacgga aucuggucca ccgacauccu uaaagaccaa      360

aaagaaccaa aaaacaaaac auuccuccgc ugcgaagcca aaaacuacag cggccgcuuc      420

accuguuggu ggcuaaccac aauaucaacc gacuuaaccu ucagcgucaa auccuccaga      480

ggauccagcg acccacaagg aguuaccugc ggagccgcaa cacucagcgc cgaacgaguc      540

cgcggagaca acaaagaaua cgaauacucc gucgaaugcc aagaagacuc agcaugcccc      600

gccgcagaag aaucccuacc caucgaagua augguagacg ccguccacaa acucaaauac      660

gaaaacuaca ccagcuccuu cuucauccga gacaucauca aacccgaccc cccaaaaaac      720

cuccaacuaa aaccccucaa aaacagccgc caaguagaag uauccuggga auaccccgac      780

accuggucca caccccacuc cuacuucucg cucacguucu gcguccaagu ccaaggcaaa      840

uccaaacgag aaaaaaaaga ccgcgucuuc accgacaaaa cuuccgccac cgucaucugc      900

cgcaaaaacg ccagcaucag cguccgcgca caagaccgcu acuacucaag cuccuggucc      960

gaaugggccu ccgucccaug cucauaa                                          987


<210>  128
<211>  984
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  IL12B(1-328) CDS mRNA opt9

<400>  128
augugucacc aacaacuugu aaucagcugg uucucccucg ucuuccucgc cucaccccuc       60

gucgccaucu gggaacucaa aaaagacguc uacguagucg aacucgacug guaccccgac      120

gccccaggag aaauggucgu acucaccugu gacacccccg aagaagacgg caucaccugg      180

acccucgacc aauccuccga aguccucggu ucaggaaaaa cccucaccau ccaaguaaaa      240

gaauuuggcg acgccgggca auauaccugc cacaaaggcg gcgagguccu aucccacuca      300

cuccuccucc uccacaagaa agaagacgga aucuggucca ccgacauccu uaaagaccaa      360

aaagaaccaa aaaacaaaac auuccuccgc ugcgaagcca aaaacuacag cggccgcuuc      420

accuguuggu ggcuaaccac aauaucaacc gacuuaaccu ucagcgucaa auccuccaga      480

ggauccagcg acccacaagg aguuaccugc ggagccgcaa cacucagcgc cgaacgaguc      540

cgcggagaca acaaagaaua cgaauacucc gucgaaugcc aagaagacuc agcaugcccc      600

gccgcagaag aaucccuacc caucgaagua augguagacg ccguccacaa acucaaauac      660

gaaaacuaca ccagcuccuu cuucauccga gacaucauca aacccgaccc cccaaaaaac      720

cuccaacuaa aaccccucaa aaacagccgc caaguagaag uauccuggga auaccccgac      780

accuggucca caccccacuc cuacuucucg cucacguucu gcguccaagu ccaaggcaaa      840

uccaaacgag aaaaaaaaga ccgcgucuuc accgacaaaa cuuccgccac cgucaucugc      900

cgcaaaaacg ccagcaucag cguccgcgca caagaccgcu acuacucaag cuccuggucc      960

gaaugggccu ccgucccaug cuca                                             984


<210>  129
<211>  921
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  IL12B(23-328) CDS mRNA opt9

<400>  129
aucugggaac ucaaaaaaga cgucuacgua gucgaacucg acugguaccc cgacgcccca       60

ggagaaaugg ucguacucac cugugacacc cccgaagaag acggcaucac cuggacccuc      120

gaccaauccu ccgaaguccu cgguucagga aaaacccuca ccauccaagu aaaagaauuu      180

ggcgacgccg ggcaauauac cugccacaaa ggcggcgagg uccuauccca cucacuccuc      240

cuccuccaca agaaagaaga cggaaucugg uccaccgaca uccuuaaaga ccaaaaagaa      300

ccaaaaaaca aaacauuccu ccgcugcgaa gccaaaaacu acagcggccg cuucaccugu      360

ugguggcuaa ccacaauauc aaccgacuua accuucagcg ucaaauccuc cagaggaucc      420

agcgacccac aaggaguuac cugcggagcc gcaacacuca gcgccgaacg aguccgcgga      480

gacaacaaag aauacgaaua cuccgucgaa ugccaagaag acucagcaug ccccgccgca      540

gaagaauccc uacccaucga aguaauggua gacgccgucc acaaacucaa auacgaaaac      600

uacaccagcu ccuucuucau ccgagacauc aucaaacccg accccccaaa aaaccuccaa      660

cuaaaacccc ucaaaaacag ccgccaagua gaaguauccu gggaauaccc cgacaccugg      720

uccacacccc acuccuacuu cucgcucacg uucugcgucc aaguccaagg caaauccaaa      780

cgagaaaaaa aagaccgcgu cuucaccgac aaaacuuccg ccaccgucau cugccgcaaa      840

aacgccagca ucagcguccg cgcacaagac cgcuacuacu caagcuccug guccgaaugg      900

gccuccgucc caugcucaua a                                                921


<210>  130
<211>  54
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Linker-sFvCC49-218 CDS mRNA opt9

<400>  130
gggaguacga gugggagugg gaagccgggg aguggggagg ggaguacgaa gggg             54


<210>  131
<211>  1632
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  IL12 CDS mRNA opt9

<400>  131
augugucacc aacaacuugu aaucagcugg uucucccucg ucuuccucgc cucaccccuc       60

gucgccaucu gggaacucaa aaaagacguc uacguagucg aacucgacug guaccccgac      120

gccccaggag aaauggucgu acucaccugu gacacccccg aagaagacgg caucaccugg      180

acccucgacc aauccuccga aguccucggu ucaggaaaaa cccucaccau ccaaguaaaa      240

gaauuuggcg acgccgggca auauaccugc cacaaaggcg gcgagguccu aucccacuca      300

cuccuccucc uccacaagaa agaagacgga aucuggucca ccgacauccu uaaagaccaa      360

aaagaaccaa aaaacaaaac auuccuccgc ugcgaagcca aaaacuacag cggccgcuuc      420

accuguuggu ggcuaaccac aauaucaacc gacuuaaccu ucagcgucaa auccuccaga      480

ggauccagcg acccacaagg aguuaccugc ggagccgcaa cacucagcgc cgaacgaguc      540

cgcggagaca acaaagaaua cgaauacucc gucgaaugcc aagaagacuc agcaugcccc      600

gccgcagaag aaucccuacc caucgaagua augguagacg ccguccacaa acucaaauac      660

gaaaacuaca ccagcuccuu cuucauccga gacaucauca aacccgaccc cccaaaaaac      720

cuccaacuaa aaccccucaa aaacagccgc caaguagaag uauccuggga auaccccgac      780

accuggucca caccccacuc cuacuucucg cucacguucu gcguccaagu ccaaggcaaa      840

uccaaacgag aaaaaaaaga ccgcgucuuc accgacaaaa cuuccgccac cgucaucugc      900

cgcaaaaacg ccagcaucag cguccgcgca caagaccgcu acuacucaag cuccuggucc      960

gaaugggccu ccgucccaug cucagggagu acgaguggga gugggaagcc ggggaguggg     1020

gaggggagua cgaaggggcg uaaccuccca gucgccaccc cagaccccgg aauguucccc     1080

ugccuccauc acucccaaaa ucuccuccgu gccgucucca acaugcucca aaaagcccgc     1140

caaacccucg aauuuuaucc augcaccucc gaagaaauag accaugaaga caucaccaaa     1200

gacaaaacau ccaccgucga agccugccuc ccccucgaac ucacaaaaaa cgaaucaugc     1260

cucaacuccc gcgaaaccuc cuucauaacc aacggcucau gccucgccuc ucgcaaaacc     1320

ucauucauga uggcccucug ccuauccucu aucuacgaag accucaaaau guaccaaguc     1380

gaauuuaaaa ccaugaacgc caaacuccuc auggacccca aacgccaaau cuuccucgac     1440

caaaacaugc ucgcagucau cgacgaacuc augcaagcac ucaacuucaa cucagaaacc     1500

gucccccaaa aauccucccu cgaagaaccc gacuucuaca aaacaaaaau aaaacucugc     1560

auccuccucc acgccuuccg cauccgagca gucaccaucg aucgcgucau guccuaccua     1620

aacgccuccu aa                                                         1632


<210>  132
<211>  786
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  CD40LG CDS mRNA opt9

<400>  132
augaucgaaa cauacaacca aacauccccc cgcuccgccg ccacaggccu ccccaucucc       60

augaaaaucu ucauguaccu ccucacagua uuccucauca cccaaaugau cggcuccgca      120

cucuuugcag ucuaucucca ccgucgccuc gacaaaaucg aagacgaacg caaccuccac      180

gaagacuucg ucuucaugaa aaccauacaa cgcugcaaca ccggcgaacg cucacucucc      240

cuacuaaacu gcgaagaaau caaaucccaa uucgaaggcu ucgucaaaga caucaugcua      300

aacaaagaag aaacaaaaaa agaaaacucc uucgaaaugc aaaaaggcga ccaaaacccc      360

caaauagccg cccacgucau cuccgaagcc uccuccaaaa ccaccuccgu ccuccaaugg      420

gccgaaaaag gcuacuacac aauguccaac aaccucguca cccucgaaaa cggcaaacaa      480

cucaccguca aacgccaagg ccucuacuac aucuacgccc aaguaaccuu cugcuccaac      540

cgcgaagccu caucucaagc ucccuucauc gccucacucu gccucaaauc acccggccgc      600

uucgaaagaa uccuccuccg cgccgcaaac acccacucau ccgccaaacc cugcggccaa      660

caauccauac accucggcgg cguuuucgag cuccaaccug gcgccuccgu cuucguaaac      720

gucaccgacc ccucacaagu cucccacggu accggcuuca ccuccuucgg acuccuaaaa      780

cucuaa                                                                 786


<210>  133
<211>  867
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  PDCD1 CDS mRNA opt10

<400>  133
augcaaaucc cccaagcccc cuggccgguc gucugggccg uccuccaacu cggcuggcgc       60

cccggauggu uccucgacuc ccccgaccgc ccguggaacc cccccaccuu cucccccgcc      120

cuccuagucg ucaccgaagg cgacaacgcc accuucaccu guuccuucuc caacaccuca      180

gaauccuucg uccucaacug guaccgcaug ucccccucca accaaaccga caaacucgcc      240

gccuuccccg aagaccgauc ccaacccggc caagacugcc gcuuccgcgu cacacaacuu      300

cccaacggac gcgacuuuca cauguccguc guccgcgccc gccgcaacga cuccggcacc      360

uaccucugcg gcgccaucuc ccucgccccc aaagcccaaa ucaaagaauc ccucagagcc      420

gaacuccgcg ucaccgaacg gcgcgccgaa guccccacug cccaccccuc ccccuccccc      480

cgccccgccg gccaauucca aacccucguc gucggcguug ucggcggccu ccucggcuca      540

cucguccucc ucgucugggu acucgccguc aucugcuccc gcgccgcgcg cggcaccauc      600

ggcgcgcgcc gcaccggaca accccuaaaa gaagaccccu ccgccguccc cgucuucucc      660

gucgacuacg gcgaacucga cuuccaaugg cgcgaaaaaa ccccggaacc ccccgucccg      720

ugcguccccg aacaaacaga auacgcgacc aucgucuucc cguccggcau gggcacaucc      780

ucacccgccc gccgaggcuc cgccgacggc ccccgauccg cccaaccccu acgccccgaa      840

gacggccacu gcuccuggcc ccucuaa                                          867


<210>  134
<211>  450
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  PDCD1(1-149) CDS mRNA opt10

<400>  134
augcaaaucc cccaagcccc cuggccgguc gucugggccg uccuccaacu cggcuggcgc       60

cccggauggu uccucgacuc ccccgaccgc ccguggaacc cccccaccuu cucccccgcc      120

cuccuagucg ucaccgaagg cgacaacgcc accuucaccu guuccuucuc caacaccuca      180

gaauccuucg uccucaacug guaccgcaug ucccccucca accaaaccga caaacucgcc      240

gccuuccccg aagaccgauc ccaacccggc caagacugcc gcuuccgcgu cacacaacuu      300

cccaacggac gcgacuuuca cauguccguc guccgcgccc gccgcaacga cuccggcacc      360

uaccucugcg gcgccaucuc ccucgccccc aaagcccaaa ucaaagaauc ccucagagcc      420

gaacuccgcg ucaccgaacg gcgcgccuaa                                       450


<210>  135
<211>  660
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  IL12A CDS mRNA opt10

<400>  135
augugccccg cccguucacu ccuccucguc gccacccucg uccuccuaga ccaccucucc       60

cuggcccgca accucccagu cgccaccccc gaccccggca uguuccccug ccuccaccac      120

ucccaaaacc uccuccgcgc cgucuccaac augcuccaaa aagcccgcca aacccucgaa      180

uuuuaccccu gcaccuccga agagaucgac cacgaagaca ucaccaaaga caaaaccucc      240

acagucgaag ccugccuccc ccucgaacuc accaaaaacg aauccugccu uaacucccgc      300

gaaaccuccu ucaucaccaa cggcuccugc cucgccuccc gcaaaaccuc cuucaugaug      360

gcccucugcc ucuccuccau cuacgaagac cucaaaaugu accaagucga auuuaaaacc      420

augaacgcca aacuccucau ggaccccaaa cgccaaaucu uccucgacca aaacaugcuc      480

gccgucaucg acgaacucau gcaagcccuc aacuucaacu ccgaaaccgu cccccaaaaa      540

uccucccucg aagaacccga cuucuacaaa accaaaauca aacuuugcau ccuccuccac      600

gcauuccgca uccgcgccgu caccaucgac cgugucauga gcuaccuaaa cgccuccuga      660


<210>  136
<211>  657
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  IL12A(1-219) CDS mRNA opt10

<400>  136
augugccccg cccguucacu ccuccucguc gccacccucg uccuccuaga ccaccucucc       60

cuggcccgca accucccagu cgccaccccc gaccccggca uguuccccug ccuccaccac      120

ucccaaaacc uccuccgcgc cgucuccaac augcuccaaa aagcccgcca aacccucgaa      180

uuuuaccccu gcaccuccga agagaucgac cacgaagaca ucaccaaaga caaaaccucc      240

acagucgaag ccugccuccc ccucgaacuc accaaaaacg aauccugccu uaacucccgc      300

gaaaccuccu ucaucaccaa cggcuccugc cucgccuccc gcaaaaccuc cuucaugaug      360

gcccucugcc ucuccuccau cuacgaagac cucaaaaugu accaagucga auuuaaaacc      420

augaacgcca aacuccucau ggaccccaaa cgccaaaucu uccucgacca aaacaugcuc      480

gccgucaucg acgaacucau gcaagcccuc aacuucaacu ccgaaaccgu cccccaaaaa      540

uccucccucg aagaacccga cuucuacaaa accaaaauca aacuuugcau ccuccuccac      600

gcauuccgca uccgcgccgu caccaucgac cgugucauga gcuaccuaaa cgccucc         657


<210>  137
<211>  594
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  IL12A(23-219) CDS mRNA opt10

<400>  137
cgcaaccucc cagucgccac ccccgacccc ggcauguucc ccugccucca ccacucccaa       60

aaccuccucc gcgccgucuc caacaugcuc caaaaagccc gccaaacccu cgaauuuuac      120

cccugcaccu ccgaagagau cgaccacgaa gacaucacca aagacaaaac cuccacaguc      180

gaagccugcc ucccccucga acucaccaaa aacgaauccu gccuuaacuc ccgcgaaacc      240

uccuucauca ccaacggcuc cugccucgcc ucccgcaaaa ccuccuucau gauggcccuc      300

ugccucuccu ccaucuacga agaccucaaa auguaccaag ucgaauuuaa aaccaugaac      360

gccaaacucc ucauggaccc caaacgccaa aucuuccucg accaaaacau gcucgccguc      420

aucgacgaac ucaugcaagc ccucaacuuc aacuccgaaa ccguccccca aaaauccucc      480

cucgaagaac ccgacuucua caaaaccaaa aucaaacuuu gcauccuccu ccacgcauuc      540

cgcauccgcg ccgucaccau cgaccguguc augagcuacc uaaacgccuc cuga            594


<210>  138
<211>  987
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  IL12B CDS mRNA opt10

<400>  138
augugccacc aacaacucgu caucuccugg uucucccucg ucuuccuagc cuccccacuc       60

gucgccaucu gggaacucaa aaaagacgua uacgucgucg aacucgacug guaccccgac      120

gccccaggag aaauggucgu ccuaaccugc gacacacccg aagaagacgg uaucaccugg      180

acccucgacc aauccuccga aguccuaggc uccggcaaga cccucaccau ccaagucaaa      240

gaauuuggcg acgcaggaca auacaccugu cacaaaggcg gcgaaguccu cagccacagc      300

cuucuccuac uccauaaaaa agaagacggc aucuggucca cugacauccu caaagaccaa      360

aaagaaccca aaaauaaaac cuuccuccgc ugcgaagcca aaaacuacuc cggccgauuc      420

accuguuggu ggcuaaccac aaucagcacc gaccucaccu ucucagucaa auccucccgc      480

ggcucaucug acccccaagg cgucacaugc ggcgccgcca cccucuccgc cgaacgcguc      540

cgcggcgaca acaaagaaua cgaauacucc gucgaauguc aagaagacuc cgccugcccc      600

gccgccgaag aaucacuccc caucgaaguc auggucgacg caguccacaa acucaaauac      660

gaaaacuaca ccuccuccuu cuucauccgc gacauaauaa aacccgaccc acccaaaaac      720

cuccaacuca agccacucaa aaacucccga caagucgaag ucuccuggga guaccccgac      780

accuggucca caccacacuc cuacuucucc cucaccuucu gcguccaagu ccaaggcaaa      840

uccaaacgcg aaaaaaaaga ccgcguuuuc acagacaaaa ccuccgccac aguaauaugc      900

cgcaaaaacg ccuccaucuc cguccgggcc caagaccgcu acuacuccuc cuccuggucc      960

gagugggccu caguccccug cagcuaa                                          987


<210>  139
<211>  984
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  IL12B(1-328) CDS mRNA opt10

<400>  139
augugccacc aacaacucgu caucuccugg uucucccucg ucuuccuagc cuccccacuc       60

gucgccaucu gggaacucaa aaaagacgua uacgucgucg aacucgacug guaccccgac      120

gccccaggag aaauggucgu ccuaaccugc gacacacccg aagaagacgg uaucaccugg      180

acccucgacc aauccuccga aguccuaggc uccggcaaga cccucaccau ccaagucaaa      240

gaauuuggcg acgcaggaca auacaccugu cacaaaggcg gcgaaguccu cagccacagc      300

cuucuccuac uccauaaaaa agaagacggc aucuggucca cugacauccu caaagaccaa      360

aaagaaccca aaaauaaaac cuuccuccgc ugcgaagcca aaaacuacuc cggccgauuc      420

accuguuggu ggcuaaccac aaucagcacc gaccucaccu ucucagucaa auccucccgc      480

ggcucaucug acccccaagg cgucacaugc ggcgccgcca cccucuccgc cgaacgcguc      540

cgcggcgaca acaaagaaua cgaauacucc gucgaauguc aagaagacuc cgccugcccc      600

gccgccgaag aaucacuccc caucgaaguc auggucgacg caguccacaa acucaaauac      660

gaaaacuaca ccuccuccuu cuucauccgc gacauaauaa aacccgaccc acccaaaaac      720

cuccaacuca agccacucaa aaacucccga caagucgaag ucuccuggga guaccccgac      780

accuggucca caccacacuc cuacuucucc cucaccuucu gcguccaagu ccaaggcaaa      840

uccaaacgcg aaaaaaaaga ccgcguuuuc acagacaaaa ccuccgccac aguaauaugc      900

cgcaaaaacg ccuccaucuc cguccgggcc caagaccgcu acuacuccuc cuccuggucc      960

gagugggccu caguccccug cagc                                             984


<210>  140
<211>  921
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  IL12B(23-328) CDS mRNA opt10

<400>  140
aucugggaac ucaaaaaaga cguauacguc gucgaacucg acugguaccc cgacgcccca       60

ggagaaaugg ucguccuaac cugcgacaca cccgaagaag acgguaucac cuggacccuc      120

gaccaauccu ccgaaguccu aggcuccggc aagacccuca ccauccaagu caaagaauuu      180

ggcgacgcag gacaauacac cugucacaaa ggcggcgaag uccucagcca cagccuucuc      240

cuacuccaua aaaaagaaga cggcaucugg uccacugaca uccucaaaga ccaaaaagaa      300

cccaaaaaua aaaccuuccu ccgcugcgaa gccaaaaacu acuccggccg auucaccugu      360

ugguggcuaa ccacaaucag caccgaccuc accuucucag ucaaauccuc ccgcggcuca      420

ucugaccccc aaggcgucac augcggcgcc gccacccucu ccgccgaacg cguccgcggc      480

gacaacaaag aauacgaaua cuccgucgaa ugucaagaag acuccgccug ccccgccgcc      540

gaagaaucac uccccaucga agucaugguc gacgcagucc acaaacucaa auacgaaaac      600

uacaccuccu ccuucuucau ccgcgacaua auaaaacccg acccacccaa aaaccuccaa      660

cucaagccac ucaaaaacuc ccgacaaguc gaagucuccu gggaguaccc cgacaccugg      720

uccacaccac acuccuacuu cucccucacc uucugcgucc aaguccaagg caaauccaaa      780

cgcgaaaaaa aagaccgcgu uuucacagac aaaaccuccg ccacaguaau augccgcaaa      840

aacgccucca ucuccguccg ggcccaagac cgcuacuacu ccuccuccug guccgagugg      900

gccucagucc ccugcagcua a                                                921


<210>  141
<211>  54
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Linker-sFvCC49-218 CDS mRNA opt10

<400>  141
gggaguacga gugggagugg gaagccgggg aguggggagg ggaguacgaa gggg             54


<210>  142
<211>  1632
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  IL12 CDS mRNA opt10

<400>  142
augugccacc aacaacucgu caucuccugg uucucccucg ucuuccuagc cuccccacuc       60

gucgccaucu gggaacucaa aaaagacgua uacgucgucg aacucgacug guaccccgac      120

gccccaggag aaauggucgu ccuaaccugc gacacacccg aagaagacgg uaucaccugg      180

acccucgacc aauccuccga aguccuaggc uccggcaaga cccucaccau ccaagucaaa      240

gaauuuggcg acgcaggaca auacaccugu cacaaaggcg gcgaaguccu cagccacagc      300

cuucuccuac uccauaaaaa agaagacggc aucuggucca cugacauccu caaagaccaa      360

aaagaaccca aaaauaaaac cuuccuccgc ugcgaagcca aaaacuacuc cggccgauuc      420

accuguuggu ggcuaaccac aaucagcacc gaccucaccu ucucagucaa auccucccgc      480

ggcucaucug acccccaagg cgucacaugc ggcgccgcca cccucuccgc cgaacgcguc      540

cgcggcgaca acaaagaaua cgaauacucc gucgaauguc aagaagacuc cgccugcccc      600

gccgccgaag aaucacuccc caucgaaguc auggucgacg caguccacaa acucaaauac      660

gaaaacuaca ccuccuccuu cuucauccgc gacauaauaa aacccgaccc acccaaaaac      720

cuccaacuca agccacucaa aaacucccga caagucgaag ucuccuggga guaccccgac      780

accuggucca caccacacuc cuacuucucc cucaccuucu gcguccaagu ccaaggcaaa      840

uccaaacgcg aaaaaaaaga ccgcguuuuc acagacaaaa ccuccgccac aguaauaugc      900

cgcaaaaacg ccuccaucuc cguccgggcc caagaccgcu acuacuccuc cuccuggucc      960

gagugggccu caguccccug cagcgggagu acgaguggga gugggaagcc ggggaguggg     1020

gaggggagua cgaaggggcg caaccuccca gucgccaccc ccgaccccgg cauguucccc     1080

ugccuccacc acucccaaaa ccuccuccgc gccgucucca acaugcucca aaaagcccgc     1140

caaacccucg aauuuuaccc cugcaccucc gaagagaucg accacgaaga caucaccaaa     1200

gacaaaaccu ccacagucga agccugccuc ccccucgaac ucaccaaaaa cgaauccugc     1260

cuuaacuccc gcgaaaccuc cuucaucacc aacggcuccu gccucgccuc ccgcaaaacc     1320

uccuucauga uggcccucug ccucuccucc aucuacgaag accucaaaau guaccaaguc     1380

gaauuuaaaa ccaugaacgc caaacuccuc auggacccca aacgccaaau cuuccucgac     1440

caaaacaugc ucgccgucau cgacgaacuc augcaagccc ucaacuucaa cuccgaaacc     1500

gucccccaaa aauccucccu cgaagaaccc gacuucuaca aaaccaaaau caaacuuugc     1560

auccuccucc acgcauuccg cauccgcgcc gucaccaucg accgugucau gagcuaccua     1620

aacgccuccu ga                                                         1632


<210>  143
<211>  786
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  CD40LG CDS mRNA opt10

<400>  143
augaucgaaa ccuacaauca aaccuccccc cgcagcgccg caacaggccu ccccaucucc       60

augaaaaucu ucauguaccu ccucaccguc uuccuaauca cccaaaugau cggcuccgcc      120

cuauucgccg ucuaccucca ccgccgccuc gacaaaaucg aagacgaacg caaccuccac      180

gaagacuuug ucuucaugaa aacuauccaa cgaugcaaca ccggcgaacg aucccuaucc      240

cuccucaacu gcgaagaaau aaaaucccaa uucgaaggau ucgucaaaga caucaugcua      300

aacaaagaag aaaccaaaaa agaaaacucc uucgaaaugc aaaaaggcga ccaaaacccc      360

caaaucgcag cccacgucau cucagaagca ucuuccaaaa ccaccuccgu ccuccaaugg      420

gccgaaaaag gcuacuacac caugucaaac aaccucguca cccucgaaaa cggcaaacaa      480

cucaccguca aacgccaagg ccucuacuac aucuacgcac aagucaccuu cugcuccaac      540

cgcgaagcau ccucccaagc ccccuucauc gccucccucu gccucaaauc ccccggccgc      600

uucgaacgca uccuccuccg cgccgcaaau acccacuccu ccgccaaacc augcggccaa      660

caauccaucc accucggcgg cgucuucgaa cuccaacccg gcgccuccgu cuucgucaac      720

gucaccgacc ccucccaagu aucccaugga accggcuuca ccuccuucgg ccuccucaaa      780

cucuag                                                                 786


<210>  144
<211>  1084
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  PDCD1 mRNA product wild type

<400>  144
gggagaaagc uuaccaugca gaucccacag gcgcccuggc cagucgucug ggcggugcua       60

caacugggcu ggcggccagg augguucuua gacuccccag acaggcccug gaaccccccc      120

accuucuccc cagcccugcu cguggugacc gaaggggaca acgccaccuu caccugcagc      180

uucuccaaca caucggagag cuucgugcua aacugguacc gcaugagccc cagcaaccag      240

acggacaagc uggccgcuuu ccccgaggac cgcagccagc ccggccagga cugccgcuuc      300

cgugucacac aacugcccaa cgggcgugac uuccacauga gcguggucag ggcccggcgc      360

aaugacagcg gcaccuaccu cuguggggcc aucucccugg cccccaaggc gcagaucaaa      420

gagagccugc gggcagagcu cagggugaca gagagaaggg cagaagugcc cacagcccac      480

cccagccccu cacccaggcc agccggccag uuccaaaccc uggugguugg ugucgugggc      540

ggccugcugg gcagccuggu gcugcuaguc uggguccugg ccgucaucug cucccgggcc      600

gcacgaggga caauaggagc caggcgcacc ggccagcccc ugaaggagga ccccucagcc      660

gugccugugu ucucugugga cuauggggag cuggauuucc aguggcgaga gaagaccccg      720

gagccccccg ugcccugugu cccugagcag acggaguaug ccaccauugu cuuuccuagc      780

ggaaugggca ccucaucccc cgcccgcagg ggcucagccg acggcccucg gagugcccag      840

ccacugaggc cugaggaugg acacugcucu uggccccucu gaggacuagu uauaagacug      900

acuagcccga ugggccuccc aacgggcccu ccuccccucc uugcaccgag auuaauaaaa      960

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa     1020

ugcauccccc cccccccccc cccccccccc ccccccaaag gcucuuuuca gagccaccag     1080

aauu                                                                  1084


<210>  145
<211>  667
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  PDCD1(1-149) mRNA product wild type

<400>  145
gggagaaagc uuaccaugca gaucccacag gcgcccuggc cagucgucug ggcggugcua       60

caacugggcu ggcggccagg augguucuua gacuccccag acaggcccug gaaccccccc      120

accuucuccc cagcccugcu cguggugacc gaaggggaca acgccaccuu caccugcagc      180

uucuccaaca caucggagag cuucgugcua aacugguacc gcaugagccc cagcaaccag      240

acggacaagc uggccgcuuu ccccgaggac cgcagccagc ccggccagga cugccgcuuc      300

cgugucacac aacugcccaa cgggcgugac uuccacauga gcguggucag ggcccggcgc      360

aaugacagcg gcaccuaccu cuguggggcc aucucccugg cccccaaggc gcagaucaaa      420

gagagccugc gggcagagcu cagggugaca gagagaaggg caugaggacu aguuauaaga      480

cugacuagcc cgaugggccu cccaacgggc ccuccucccc uccuugcacc gagauuaaua      540

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa      600

aaaugcaucc cccccccccc cccccccccc ccccccccca aaggcucuuu ucagagccac      660

cagaauu                                                                667


<210>  146
<211>  877
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  IL12A mRNA product wild type

<400>  146
gggagaaagc uuaccaugug uccagcgcgc agccuccucc uuguggcuac ccugguccuc       60

cuggaccacc ucaguuuggc cagaaaccuc cccguggcca cuccagaccc aggaauguuc      120

ccaugccuuc accacuccca aaaccugcug agggccguca gcaacaugcu ccagaaggcc      180

agacaaacuc uagaauuuua cccuugcacu ucugaagaga uugaucauga agauaucaca      240

aaagauaaaa ccagcacagu ggaggccugu uuaccauugg aauuaaccaa gaaugagagu      300

ugccuaaauu ccagagagac cucuuucaua acuaauggga guugccuggc cuccagaaag      360

accucuuuua ugauggcccu gugccuuagu aguauuuaug aagacuugaa gauguaccag      420

guggaguuca agaccaugaa ugcaaagcuu cugauggauc cuaagaggca gaucuuucua      480

gaucaaaaca ugcuggcagu uauugaugag cugaugcagg cccugaauuu caacagugag      540

acugugccac aaaaauccuc ccuugaagaa ccggauuuuu auaaaacuaa aaucaagcuc      600

ugcauacuuc uucaugcuuu cagaauucgg gcagugacua uugauagagu gaugagcuau      660

cugaaugcuu ccuaaggacu aguuauaaga cugacuagcc cgaugggccu cccaacgggc      720

ccuccucccc uccuugcacc gagauuaaua aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa      780

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaugcaucc cccccccccc cccccccccc      840

ccccccccca aaggcucuuu ucagagccac cagaauu                               877


<210>  147
<211>  874
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  IL12A(1-219) mRNA product wild type

<400>  147
gggagaaagc uuaccaugug uccagcgcgc agccuccucc uuguggcuac ccugguccuc       60

cuggaccacc ucaguuuggc cagaaaccuc cccguggcca cuccagaccc aggaauguuc      120

ccaugccuuc accacuccca aaaccugcug agggccguca gcaacaugcu ccagaaggcc      180

agacaaacuc uagaauuuua cccuugcacu ucugaagaga uugaucauga agauaucaca      240

aaagauaaaa ccagcacagu ggaggccugu uuaccauugg aauuaaccaa gaaugagagu      300

ugccuaaauu ccagagagac cucuuucaua acuaauggga guugccuggc cuccagaaag      360

accucuuuua ugauggcccu gugccuuagu aguauuuaug aagacuugaa gauguaccag      420

guggaguuca agaccaugaa ugcaaagcuu cugauggauc cuaagaggca gaucuuucua      480

gaucaaaaca ugcuggcagu uauugaugag cugaugcagg cccugaauuu caacagugag      540

acugugccac aaaaauccuc ccuugaagaa ccggauuuuu auaaaacuaa aaucaagcuc      600

ugcauacuuc uucaugcuuu cagaauucgg gcagugacua uugauagagu gaugagcuau      660

cugaaugcuu ccggacuagu uauaagacug acuagcccga ugggccuccc aacgggcccu      720

ccuccccucc uugcaccgag auuaauaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa      780

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa ugcauccccc cccccccccc cccccccccc      840

ccccccaaag gcucuuuuca gagccaccag aauu                                  874


<210>  148
<211>  811
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  IL12A(23-219) mRNA product wild type

<400>  148
gggagaaagc uuaccagaaa ccuccccgug gccacuccag acccaggaau guucccaugc       60

cuucaccacu cccaaaaccu gcugagggcc gucagcaaca ugcuccagaa ggccagacaa      120

acucuagaau uuuacccuug cacuucugaa gagauugauc augaagauau cacaaaagau      180

aaaaccagca caguggaggc cuguuuacca uuggaauuaa ccaagaauga gaguugccua      240

aauuccagag agaccucuuu cauaacuaau gggaguugcc uggccuccag aaagaccucu      300

uuuaugaugg cccugugccu uaguaguauu uaugaagacu ugaagaugua ccagguggag      360

uucaagacca ugaaugcaaa gcuucugaug gauccuaaga ggcagaucuu ucuagaucaa      420

aacaugcugg caguuauuga ugagcugaug caggcccuga auuucaacag ugagacugug      480

ccacaaaaau ccucccuuga agaaccggau uuuuauaaaa cuaaaaucaa gcucugcaua      540

cuucuucaug cuuucagaau ucgggcagug acuauugaua gagugaugag cuaucugaau      600

gcuuccuaag gacuaguuau aagacugacu agcccgaugg gccucccaac gggcccuccu      660

ccccuccuug caccgagauu aauaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa      720

aaaaaaaaaa aaaaaaaaaa aaaaaaaugc aucccccccc cccccccccc cccccccccc      780

cccaaaggcu cuuuucagag ccaccagaau u                                     811


<210>  149
<211>  1204
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  IL12B mRNA product wild type

<400>  149
gggagaaagc uuaccaugug ucaccagcag uuggucaucu cuugguuuuc ccugguuuuu       60

cuggcaucuc cccucguggc cauaugggaa cugaagaaag auguuuaugu cguagaauug      120

gauugguauc cggaugcccc uggagaaaug gugguccuca ccugugacac cccugaagaa      180

gaugguauca ccuggaccuu ggaccagagc agugaggucu uaggcucugg caaaacccug      240

accauccaag ucaaagaguu uggagaugcu ggccaguaca ccugucacaa aggaggcgag      300

guucuaagcc auucgcuccu gcugcuucac aaaaaggaag auggaauuug guccacugau      360

auuuuaaagg accagaaaga acccaaaaau aagaccuuuc uaagaugcga ggccaagaau      420

uauucuggac guuucaccug cugguggcug acgacaauca guacugauuu gacauucagu      480

gucaaaagca gcagaggcuc uucugacccc caagggguga cgugcggagc ugcuacacuc      540

ucugcagaga gagucagagg ggacaacaag gaguaugagu acucagugga gugccaggag      600

gacagugccu gcccagcugc ugaggagagu cugcccauug aggucauggu ggaugccguu      660

cacaagcuca aguaugaaaa cuacaccagc agcuucuuca ucagggacau caucaaaccu      720

gacccaccca agaacuugca gcugaagcca uuaaagaauu cucggcaggu ggaggucagc      780

ugggaguacc cugacaccug gaguacucca cauuccuacu ucucccugac auucugcguu      840

cagguccagg gcaagagcaa gagagaaaag aaagauagag ucuucacgga caagaccuca      900

gccacgguca ucugccgcaa aaaugccagc auuagcgugc gggcccagga ccgcuacuau      960

agcucaucuu ggagcgaaug ggcaucugug cccugcaguu agggacuagu uauaagacug     1020

acuagcccga ugggccuccc aacgggcccu ccuccccucc uugcaccgag auuaauaaaa     1080

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa     1140

ugcauccccc cccccccccc cccccccccc ccccccaaag gcucuuuuca gagccaccag     1200

aauu                                                                  1204


<210>  150
<211>  1201
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  IL12B(1-328) mRNA product wild type

<400>  150
gggagaaagc uuaccaugug ucaccagcag uuggucaucu cuugguuuuc ccugguuuuu       60

cuggcaucuc cccucguggc cauaugggaa cugaagaaag auguuuaugu cguagaauug      120

gauugguauc cggaugcccc uggagaaaug gugguccuca ccugugacac cccugaagaa      180

gaugguauca ccuggaccuu ggaccagagc agugaggucu uaggcucugg caaaacccug      240

accauccaag ucaaagaguu uggagaugcu ggccaguaca ccugucacaa aggaggcgag      300

guucuaagcc auucgcuccu gcugcuucac aaaaaggaag auggaauuug guccacugau      360

auuuuaaagg accagaaaga acccaaaaau aagaccuuuc uaagaugcga ggccaagaau      420

uauucuggac guuucaccug cugguggcug acgacaauca guacugauuu gacauucagu      480

gucaaaagca gcagaggcuc uucugacccc caagggguga cgugcggagc ugcuacacuc      540

ucugcagaga gagucagagg ggacaacaag gaguaugagu acucagugga gugccaggag      600

gacagugccu gcccagcugc ugaggagagu cugcccauug aggucauggu ggaugccguu      660

cacaagcuca aguaugaaaa cuacaccagc agcuucuuca ucagggacau caucaaaccu      720

gacccaccca agaacuugca gcugaagcca uuaaagaauu cucggcaggu ggaggucagc      780

ugggaguacc cugacaccug gaguacucca cauuccuacu ucucccugac auucugcguu      840

cagguccagg gcaagagcaa gagagaaaag aaagauagag ucuucacgga caagaccuca      900

gccacgguca ucugccgcaa aaaugccagc auuagcgugc gggcccagga ccgcuacuau      960

agcucaucuu ggagcgaaug ggcaucugug cccugcagug gacuaguuau aagacugacu     1020

agcccgaugg gccucccaac gggcccuccu ccccuccuug caccgagauu aauaaaaaaa     1080

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaugc     1140

aucccccccc cccccccccc cccccccccc cccaaaggcu cuuuucagag ccaccagaau     1200

u                                                                     1201


<210>  151
<211>  1138
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  IL12B(23-328) mRNA product wild type

<400>  151
gggagaaagc uuaccauaug ggaacugaag aaagauguuu augucguaga auuggauugg       60

uauccggaug ccccuggaga aauggugguc cucaccugug acaccccuga agaagauggu      120

aucaccugga ccuuggacca gagcagugag gucuuaggcu cuggcaaaac ccugaccauc      180

caagucaaag aguuuggaga ugcuggccag uacaccuguc acaaaggagg cgagguucua      240

agccauucgc uccugcugcu ucacaaaaag gaagauggaa uuugguccac ugauauuuua      300

aaggaccaga aagaacccaa aaauaagacc uuucuaagau gcgaggccaa gaauuauucu      360

ggacguuuca ccugcuggug gcugacgaca aucaguacug auuugacauu cagugucaaa      420

agcagcagag gcucuucuga cccccaaggg gugacgugcg gagcugcuac acucucugca      480

gagagaguca gaggggacaa caaggaguau gaguacucag uggagugcca ggaggacagu      540

gccugcccag cugcugagga gagucugccc auugagguca ugguggaugc cguucacaag      600

cucaaguaug aaaacuacac cagcagcuuc uucaucaggg acaucaucaa accugaccca      660

cccaagaacu ugcagcugaa gccauuaaag aauucucggc agguggaggu cagcugggag      720

uacccugaca ccuggaguac uccacauucc uacuucuccc ugacauucug cguucagguc      780

cagggcaaga gcaagagaga aaagaaagau agagucuuca cggacaagac cucagccacg      840

gucaucugcc gcaaaaaugc cagcauuagc gugcgggccc aggaccgcua cuauagcuca      900

ucuuggagcg aaugggcauc ugugcccugc aguuagggac uaguuauaag acugacuagc      960

ccgaugggcc ucccaacggg cccuccuccc cuccuugcac cgagauuaau aaaaaaaaaa     1020

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaugcauc     1080

cccccccccc cccccccccc cccccccccc aaaggcucuu uucagagcca ccagaauu       1138


<210>  152
<211>  271
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Linker-sFvCC49-218 mRNA product wild type

<400>  152
gggagaaagc uuaccggcag uacuucgggc agugguaagc cugguagugg ugaggguagu       60

acuaagggug gacuaguuau aagacugacu agcccgaugg gccucccaac gggcccuccu      120

ccccuccuug caccgagauu aauaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa      180

aaaaaaaaaa aaaaaaaaaa aaaaaaaugc aucccccccc cccccccccc cccccccccc      240

cccaaaggcu cuuuucagag ccaccagaau u                                     271


<210>  153
<211>  1849
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  IL12 mRNA product wild type

<400>  153
gggagaaagc uuaccaugug ucaccagcag uuggucaucu cuugguuuuc ccugguuuuu       60

cuggcaucuc cccucguggc cauaugggaa cugaagaaag auguuuaugu cguagaauug      120

gauugguauc cggaugcccc uggagaaaug gugguccuca ccugugacac cccugaagaa      180

gaugguauca ccuggaccuu ggaccagagc agugaggucu uaggcucugg caaaacccug      240

accauccaag ucaaagaguu uggagaugcu ggccaguaca ccugucacaa aggaggcgag      300

guucuaagcc auucgcuccu gcugcuucac aaaaaggaag auggaauuug guccacugau      360

auuuuaaagg accagaaaga acccaaaaau aagaccuuuc uaagaugcga ggccaagaau      420

uauucuggac guuucaccug cugguggcug acgacaauca guacugauuu gacauucagu      480

gucaaaagca gcagaggcuc uucugacccc caagggguga cgugcggagc ugcuacacuc      540

ucugcagaga gagucagagg ggacaacaag gaguaugagu acucagugga gugccaggag      600

gacagugccu gcccagcugc ugaggagagu cugcccauug aggucauggu ggaugccguu      660

cacaagcuca aguaugaaaa cuacaccagc agcuucuuca ucagggacau caucaaaccu      720

gacccaccca agaacuugca gcugaagcca uuaaagaauu cucggcaggu ggaggucagc      780

ugggaguacc cugacaccug gaguacucca cauuccuacu ucucccugac auucugcguu      840

cagguccagg gcaagagcaa gagagaaaag aaagauagag ucuucacgga caagaccuca      900

gccacgguca ucugccgcaa aaaugccagc auuagcgugc gggcccagga ccgcuacuau      960

agcucaucuu ggagcgaaug ggcaucugug cccugcagug gcaguacuuc gggcaguggu     1020

aagccuggua guggugaggg uaguacuaag gguagaaacc uccccguggc cacuccagac     1080

ccaggaaugu ucccaugccu ucaccacucc caaaaccugc ugagggccgu cagcaacaug     1140

cuccagaagg ccagacaaac ucuagaauuu uacccuugca cuucugaaga gauugaucau     1200

gaagauauca caaaagauaa aaccagcaca guggaggccu guuuaccauu ggaauuaacc     1260

aagaaugaga guugccuaaa uuccagagag accucuuuca uaacuaaugg gaguugccug     1320

gccuccagaa agaccucuuu uaugauggcc cugugccuua guaguauuua ugaagacuug     1380

aagauguacc agguggaguu caagaccaug aaugcaaagc uucugaugga uccuaagagg     1440

cagaucuuuc uagaucaaaa caugcuggca guuauugaug agcugaugca ggcccugaau     1500

uucaacagug agacugugcc acaaaaaucc ucccuugaag aaccggauuu uuauaaaacu     1560

aaaaucaagc ucugcauacu ucuucaugcu uucagaauuc gggcagugac uauugauaga     1620

gugaugagcu aucugaaugc uuccuaagga cuaguuauaa gacugacuag cccgaugggc     1680

cucccaacgg gcccuccucc ccuccuugca ccgagauuaa uaaaaaaaaa aaaaaaaaaa     1740

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaugcau cccccccccc     1800

cccccccccc cccccccccc caaaggcucu uuucagagcc accagaauu                 1849


<210>  154
<211>  1003
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  CD40LG mRNA product wild type

<400>  154
gggagaaagc uuaccaugau cgaaacauac aaccaaacuu cuccccgauc ugcggccacu       60

ggacugccca ucagcaugaa aauuuuuaug uauuuacuua cuguuuuucu uaucacccag      120

augauugggu cagcacuuuu ugcuguguau cuucauagaa gguuggacaa gauagaagau      180

gaaaggaauc uucaugaaga uuuuguauuc augaaaacga uacagagaug caacacagga      240

gaaagauccu uauccuuacu gaacugugag gagauuaaaa gccaguuuga aggcuuugug      300

aaggauauaa uguuaaacaa agaggagacg aagaaagaaa acagcuuuga aaugcaaaaa      360

ggugaucaga auccucaaau ugcggcacau gucauaagug aggccagcag uaaaacaaca      420

ucuguguuac agugggcuga aaaaggauac uacaccauga gcaacaacuu gguaacccug      480

gaaaauggga aacagcugac cguuaaaaga caaggacucu auuauaucua ugcccaaguc      540

accuucuguu ccaaucggga agcuucgagu caagcuccau uuauagccag ccucugccua      600

aagucccccg guagauucga gagaaucuua cucagagcug caaauaccca caguuccgcc      660

aaaccuugcg ggcaacaauc cauucacuug ggaggaguau uugaauugca accaggugcu      720

ucgguguuug ucaaugugac ugauccaagc caagugagcc auggcacugg cuucacgucc      780

uuuggcuuac ucaaacucug aggacuaguu auaagacuga cuagcccgau gggccuccca      840

acgggcccuc cuccccuccu ugcaccgaga uuaauaaaaa aaaaaaaaaa aaaaaaaaaa      900

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaau gcaucccccc cccccccccc      960

cccccccccc cccccaaagg cucuuuucag agccaccaga auu                       1003


<210>  155
<211>  1084
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  PDCD1 mRNA product opt1

<400>  155
gggagaaagc uuaccaugca gaucccccag gccccguggc ccguggucug ggccgugcug       60

cagcucggcu ggcgccccgg gugguuccug gacagccccg accggccgug gaacccgccc      120

accuucuccc ccgcgcugcu cguggucacc gagggcgaca acgccacguu cacgugcagc      180

uucuccaaca ccagcgaguc cuucgugcug aacugguacc gcaugagccc cuccaaccag      240

accgacaagc uggccgccuu ccccgaggac cggagccagc ccgggcagga cugccgcuuc      300

cgggugaccc agcuccccaa cggccgcgac uuccacaugu ccgucgugcg ggcccgccgg      360

aacgacagcg ggaccuaccu gugcggcgcg aucucccugg ccccgaaggc ccagaucaag      420

gagagccucc gcgccgagcu gcgggugacc gagcgccggg cggagguccc caccgcccac      480

cccuccccca gcccgcgccc cgccggccag uuccagacgc uggugguggg ggucgugggc      540

gggcuccugg gcucccuggu gcuccugguc ugggugcugg ccgugaucug cagccgggcc      600

gcgcgcggga ccaucggcgc ccggcgcacc ggccagcccc ucaaggagga ccccuccgcc      660

gucccggugu ucagcgugga cuacggggag cuggacuucc aguggcggga gaagaccccc      720

gagccgcccg uccccugcgu gcccgagcag acggaguacg ccaccaucgu guuccccucc      780

ggcaugggga ccagcagccc cgcccgccgg ggcuccgcgg acggcccgcg cagcgcccag      840

ccccugcgcc ccgaggacgg gcacugcucc uggccgcucu gaggacuagu uauaagacug      900

acuagcccga ugggccuccc aacgggcccu ccuccccucc uugcaccgag auuaauaaaa      960

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa     1020

ugcauccccc cccccccccc cccccccccc ccccccaaag gcucuuuuca gagccaccag     1080

aauu                                                                  1084


<210>  156
<211>  667
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  PDCD1(1-149) mRNA product opt1

<400>  156
gggagaaagc uuaccaugca gaucccccag gccccguggc ccguggucug ggccgugcug       60

cagcucggcu ggcgccccgg gugguuccug gacagccccg accggccgug gaacccgccc      120

accuucuccc ccgcgcugcu cguggucacc gagggcgaca acgccacguu cacgugcagc      180

uucuccaaca ccagcgaguc cuucgugcug aacugguacc gcaugagccc cuccaaccag      240

accgacaagc uggccgccuu ccccgaggac cggagccagc ccgggcagga cugccgcuuc      300

cgggugaccc agcuccccaa cggccgcgac uuccacaugu ccgucgugcg ggcccgccgg      360

aacgacagcg ggaccuaccu gugcggcgcg aucucccugg ccccgaaggc ccagaucaag      420

gagagccucc gcgccgagcu gcgggugacc gagcgccggg cgugaggacu aguuauaaga      480

cugacuagcc cgaugggccu cccaacgggc ccuccucccc uccuugcacc gagauuaaua      540

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa      600

aaaugcaucc cccccccccc cccccccccc ccccccccca aaggcucuuu ucagagccac      660

cagaauu                                                                667


<210>  157
<211>  877
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  IL12A mRNA product opt1

<400>  157
gggagaaagc uuaccaugug ccccgcccgc agccugcucc ugguggccac ccugguccuc       60

cuggaccacc ugucccucgc gcggaaccug ccgguggcca cccccgaccc cggcauguuc      120

cccugccugc accacagcca gaaccuccug cgcgccgugu ccaacaugcu gcagaaggcc      180

cggcagacgc ucgaguucua cccgugcacc agcgaggaga ucgaccacga ggacaucacc      240

aaggacaaga ccuccacggu cgaggccugc cugccccugg agcucaccaa gaacgagagc      300

ugccugaacu cccgcgagac cagcuucauc accaacgggu ccugccuggc gagccggaag      360

acguccuuca ugauggcccu cugccugagc uccaucuacg aggaccugaa gauguaccag      420

guggaguuca agaccaugaa cgccaagcuc cugauggacc ccaagcgcca gaucuuccug      480

gaccagaaca ugcucgccgu gaucgacgag cugaugcagg cgcugaacuu caacagcgag      540

accguccccc agaaguccag ccucgaggag ccggacuucu acaagaccaa gaucaagcug      600

ugcauccugc uccacgccuu ccggauccgc gccgugacga ucgaccgggu gauguccuac      660

cugaacgcca gcugaggacu aguuauaaga cugacuagcc cgaugggccu cccaacgggc      720

ccuccucccc uccuugcacc gagauuaaua aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa      780

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaugcaucc cccccccccc cccccccccc      840

ccccccccca aaggcucuuu ucagagccac cagaauu                               877


<210>  158
<211>  874
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  IL12A(1-219) mRNA product opt1

<400>  158
gggagaaagc uuaccaugug ccccgcccgc agccugcucc ugguggccac ccugguccuc       60

cuggaccacc ugucccucgc gcggaaccug ccgguggcca cccccgaccc cggcauguuc      120

cccugccugc accacagcca gaaccuccug cgcgccgugu ccaacaugcu gcagaaggcc      180

cggcagacgc ucgaguucua cccgugcacc agcgaggaga ucgaccacga ggacaucacc      240

aaggacaaga ccuccacggu cgaggccugc cugccccugg agcucaccaa gaacgagagc      300

ugccugaacu cccgcgagac cagcuucauc accaacgggu ccugccuggc gagccggaag      360

acguccuuca ugauggcccu cugccugagc uccaucuacg aggaccugaa gauguaccag      420

guggaguuca agaccaugaa cgccaagcuc cugauggacc ccaagcgcca gaucuuccug      480

gaccagaaca ugcucgccgu gaucgacgag cugaugcagg cgcugaacuu caacagcgag      540

accguccccc agaaguccag ccucgaggag ccggacuucu acaagaccaa gaucaagcug      600

ugcauccugc uccacgccuu ccggauccgc gccgugacga ucgaccgggu gauguccuac      660

cugaacgcca gcggacuagu uauaagacug acuagcccga ugggccuccc aacgggcccu      720

ccuccccucc uugcaccgag auuaauaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa      780

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa ugcauccccc cccccccccc cccccccccc      840

ccccccaaag gcucuuuuca gagccaccag aauu                                  874


<210>  159
<211>  811
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  IL12A(23-219) mRNA product opt1

<400>  159
gggagaaagc uuacccggaa ccugccggug gccacccccg accccggcau guuccccugc       60

cugcaccaca gccagaaccu ccugcgcgcc guguccaaca ugcugcagaa ggcccggcag      120

acgcucgagu ucuacccgug caccagcgag gagaucgacc acgaggacau caccaaggac      180

aagaccucca cggucgaggc cugccugccc cuggagcuca ccaagaacga gagcugccug      240

aacucccgcg agaccagcuu caucaccaac ggguccugcc uggcgagccg gaagacgucc      300

uucaugaugg cccucugccu gagcuccauc uacgaggacc ugaagaugua ccagguggag      360

uucaagacca ugaacgccaa gcuccugaug gaccccaagc gccagaucuu ccuggaccag      420

aacaugcucg ccgugaucga cgagcugaug caggcgcuga acuucaacag cgagaccguc      480

ccccagaagu ccagccucga ggagccggac uucuacaaga ccaagaucaa gcugugcauc      540

cugcuccacg ccuuccggau ccgcgccgug acgaucgacc gggugauguc cuaccugaac      600

gccagcugag gacuaguuau aagacugacu agcccgaugg gccucccaac gggcccuccu      660

ccccuccuug caccgagauu aauaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa      720

aaaaaaaaaa aaaaaaaaaa aaaaaaaugc aucccccccc cccccccccc cccccccccc      780

cccaaaggcu cuuuucagag ccaccagaau u                                     811


<210>  160
<211>  1204
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  IL12B mRNA product opt1

<400>  160
gggagaaagc uuaccaugug ccaccagcag cuggugauca gcugguucuc ccucgucuuc       60

cuggccagcc cccugguggc caucugggag cucaagaagg acguguacgu cguggagcug      120

gacugguacc cggacgcgcc cggcgagaug gugguccuga ccugcgacac ccccgaggag      180

gacgggauca cguggacccu cgaccagucc agcgaggugc ugggcuccgg gaagacccug      240

accauccagg ugaaggaguu cggcgacgcc gggcaguaca cgugccacaa gggcggcgag      300

guccucagcc acucccugcu gcuccugcac aagaaggagg acgggaucug gagcaccgac      360

auccugaagg accagaagga gcccaagaac aagaccuucc uccgcugcga ggccaagaac      420

uacuccggcc gguucacgug cugguggcug accaccauca gcaccgaccu gaccuucucc      480

gucaagagcu cccgcgggag cuccgacccg cagggcguga cgugcggggc cgccacccuc      540

agcgcggagc gggugcgcgg cgacaacaag gaguacgagu acuccgugga gugccaggag      600

gacagcgccu gccccgccgc cgaggagucc cugcccaucg aggugauggu cgacgcggug      660

cacaagcuga aguacgagaa cuacaccagc agcuucuuca uccgggacau caucaagccc      720

gacccgccca agaaccucca gcugaagccc cugaagaacu cccgccaggu ggaggucagc      780

ugggaguacc ccgacaccug guccacgccg cacagcuacu ucucccucac cuucugcguc      840

caggugcagg gcaagagcaa gcgggagaag aaggaccgcg uguucaccga caagaccucc      900

gccacgguga ucugccggaa gaacgccagc aucuccgugc gcgcccagga ccgguacuac      960

agcuccagcu gguccgagug ggccagcguc cccugcuccu gaggacuagu uauaagacug     1020

acuagcccga ugggccuccc aacgggcccu ccuccccucc uugcaccgag auuaauaaaa     1080

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa     1140

ugcauccccc cccccccccc cccccccccc ccccccaaag gcucuuuuca gagccaccag     1200

aauu                                                                  1204


<210>  161
<211>  1201
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  IL12B(1-328) mRNA product opt1

<400>  161
gggagaaagc uuaccaugug ccaccagcag cuggugauca gcugguucuc ccucgucuuc       60

cuggccagcc cccugguggc caucugggag cucaagaagg acguguacgu cguggagcug      120

gacugguacc cggacgcgcc cggcgagaug gugguccuga ccugcgacac ccccgaggag      180

gacgggauca cguggacccu cgaccagucc agcgaggugc ugggcuccgg gaagacccug      240

accauccagg ugaaggaguu cggcgacgcc gggcaguaca cgugccacaa gggcggcgag      300

guccucagcc acucccugcu gcuccugcac aagaaggagg acgggaucug gagcaccgac      360

auccugaagg accagaagga gcccaagaac aagaccuucc uccgcugcga ggccaagaac      420

uacuccggcc gguucacgug cugguggcug accaccauca gcaccgaccu gaccuucucc      480

gucaagagcu cccgcgggag cuccgacccg cagggcguga cgugcggggc cgccacccuc      540

agcgcggagc gggugcgcgg cgacaacaag gaguacgagu acuccgugga gugccaggag      600

gacagcgccu gccccgccgc cgaggagucc cugcccaucg aggugauggu cgacgcggug      660

cacaagcuga aguacgagaa cuacaccagc agcuucuuca uccgggacau caucaagccc      720

gacccgccca agaaccucca gcugaagccc cugaagaacu cccgccaggu ggaggucagc      780

ugggaguacc ccgacaccug guccacgccg cacagcuacu ucucccucac cuucugcguc      840

caggugcagg gcaagagcaa gcgggagaag aaggaccgcg uguucaccga caagaccucc      900

gccacgguga ucugccggaa gaacgccagc aucuccgugc gcgcccagga ccgguacuac      960

agcuccagcu gguccgagug ggccagcguc cccugcuccg gacuaguuau aagacugacu     1020

agcccgaugg gccucccaac gggcccuccu ccccuccuug caccgagauu aauaaaaaaa     1080

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaugc     1140

aucccccccc cccccccccc cccccccccc cccaaaggcu cuuuucagag ccaccagaau     1200

u                                                                     1201


<210>  162
<211>  1138
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  IL12B(23-328) mRNA product opt1

<400>  162
gggagaaagc uuaccaucug ggagcucaag aaggacgugu acgucgugga gcuggacugg       60

uacccggacg cgcccggcga gauggugguc cugaccugcg acacccccga ggaggacggg      120

aucacgugga cccucgacca guccagcgag gugcugggcu ccgggaagac ccugaccauc      180

caggugaagg aguucggcga cgccgggcag uacacgugcc acaagggcgg cgagguccuc      240

agccacuccc ugcugcuccu gcacaagaag gaggacggga ucuggagcac cgacauccug      300

aaggaccaga aggagcccaa gaacaagacc uuccuccgcu gcgaggccaa gaacuacucc      360

ggccgguuca cgugcuggug gcugaccacc aucagcaccg accugaccuu cuccgucaag      420

agcucccgcg ggagcuccga cccgcagggc gugacgugcg gggccgccac ccucagcgcg      480

gagcgggugc gcggcgacaa caaggaguac gaguacuccg uggagugcca ggaggacagc      540

gccugccccg ccgccgagga gucccugccc aucgagguga uggucgacgc ggugcacaag      600

cugaaguacg agaacuacac cagcagcuuc uucauccggg acaucaucaa gcccgacccg      660

cccaagaacc uccagcugaa gccccugaag aacucccgcc agguggaggu cagcugggag      720

uaccccgaca ccugguccac gccgcacagc uacuucuccc ucaccuucug cguccaggug      780

cagggcaaga gcaagcggga gaagaaggac cgcguguuca ccgacaagac cuccgccacg      840

gugaucugcc ggaagaacgc cagcaucucc gugcgcgccc aggaccggua cuacagcucc      900

agcugguccg agugggccag cguccccugc uccugaggac uaguuauaag acugacuagc      960

ccgaugggcc ucccaacggg cccuccuccc cuccuugcac cgagauuaau aaaaaaaaaa     1020

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaugcauc     1080

cccccccccc cccccccccc cccccccccc aaaggcucuu uucagagcca ccagaauu       1138


<210>  163
<211>  271
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Linker-sFvCC49-218 mRNA product opt1

<400>  163
gggagaaagc uuaccggcag caccuccggg agcggcaagc ccggguccgg cgaggggagc       60

accaagggcg gacuaguuau aagacugacu agcccgaugg gccucccaac gggcccuccu      120

ccccuccuug caccgagauu aauaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa      180

aaaaaaaaaa aaaaaaaaaa aaaaaaaugc aucccccccc cccccccccc cccccccccc      240

cccaaaggcu cuuuucagag ccaccagaau u                                     271


<210>  164
<211>  1849
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  IL12 mRNA product opt1

<400>  164
gggagaaagc uuaccaugug ccaccagcag cuggugauca gcugguucuc ccucgucuuc       60

cuggccagcc cccugguggc caucugggag cucaagaagg acguguacgu cguggagcug      120

gacugguacc cggacgcgcc cggcgagaug gugguccuga ccugcgacac ccccgaggag      180

gacgggauca cguggacccu cgaccagucc agcgaggugc ugggcuccgg gaagacccug      240

accauccagg ugaaggaguu cggcgacgcc gggcaguaca cgugccacaa gggcggcgag      300

guccucagcc acucccugcu gcuccugcac aagaaggagg acgggaucug gagcaccgac      360

auccugaagg accagaagga gcccaagaac aagaccuucc uccgcugcga ggccaagaac      420

uacuccggcc gguucacgug cugguggcug accaccauca gcaccgaccu gaccuucucc      480

gucaagagcu cccgcgggag cuccgacccg cagggcguga cgugcggggc cgccacccuc      540

agcgcggagc gggugcgcgg cgacaacaag gaguacgagu acuccgugga gugccaggag      600

gacagcgccu gccccgccgc cgaggagucc cugcccaucg aggugauggu cgacgcggug      660

cacaagcuga aguacgagaa cuacaccagc agcuucuuca uccgggacau caucaagccc      720

gacccgccca agaaccucca gcugaagccc cugaagaacu cccgccaggu ggaggucagc      780

ugggaguacc ccgacaccug guccacgccg cacagcuacu ucucccucac cuucugcguc      840

caggugcagg gcaagagcaa gcgggagaag aaggaccgcg uguucaccga caagaccucc      900

gccacgguga ucugccggaa gaacgccagc aucuccgugc gcgcccagga ccgguacuac      960

agcuccagcu gguccgagug ggccagcguc cccugcuccg gcagcaccuc cgggagcggc     1020

aagcccgggu ccggcgaggg gagcaccaag ggccggaacc ugccgguggc cacccccgac     1080

cccggcaugu uccccugccu gcaccacagc cagaaccucc ugcgcgccgu guccaacaug     1140

cugcagaagg cccggcagac gcucgaguuc uacccgugca ccagcgagga gaucgaccac     1200

gaggacauca ccaaggacaa gaccuccacg gucgaggccu gccugccccu ggagcucacc     1260

aagaacgaga gcugccugaa cucccgcgag accagcuuca ucaccaacgg guccugccug     1320

gcgagccgga agacguccuu caugauggcc cucugccuga gcuccaucua cgaggaccug     1380

aagauguacc agguggaguu caagaccaug aacgccaagc uccugaugga ccccaagcgc     1440

cagaucuucc uggaccagaa caugcucgcc gugaucgacg agcugaugca ggcgcugaac     1500

uucaacagcg agaccguccc ccagaagucc agccucgagg agccggacuu cuacaagacc     1560

aagaucaagc ugugcauccu gcuccacgcc uuccggaucc gcgccgugac gaucgaccgg     1620

gugauguccu accugaacgc cagcugagga cuaguuauaa gacugacuag cccgaugggc     1680

cucccaacgg gcccuccucc ccuccuugca ccgagauuaa uaaaaaaaaa aaaaaaaaaa     1740

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaugcau cccccccccc     1800

cccccccccc cccccccccc caaaggcucu uuucagagcc accagaauu                 1849


<210>  165
<211>  1003
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  CD40LG mRNA product opt1

<400>  165
gggagaaagc uuaccaugau cgagaccuac aaccagacca gcccccgcuc cgccgccacg       60

ggccugccga ucagcaugaa gaucuucaug uaccuccuga ccguguuccu gaucacccag      120

augaucgggu ccgcgcuguu cgccgucuac cugcaccggc gccuggacaa gaucgaggac      180

gagcggaacc uccacgagga cuucguguuc augaagacca uccagcgcug caacacgggc      240

gagcggagcc ugucccugcu caacugcgag gagaucaaga gccaguucga gggguucgug      300

aaggacauca ugcugaacaa ggaggagacc aagaaggaga acuccuucga gaugcagaag      360

ggcgaccaga acccccagau cgccgcccac gucaucagcg aggccuccag caagaccacc      420

uccgugcugc agugggcgga gaagggguac uacacgauga gcaacaaccu cgugacccug      480

gagaacggca agcagcugac cgucaagcgc cagggccucu acuacaucua cgcccaggug      540

accuucugcu ccaaccggga ggccagcucc caggcccccu ucaucgcgag ccugugccug      600

aagucccccg ggcgcuucga gcggauccuc cugcgcgccg ccaacacgca cagcuccgcc      660

aagccgugcg gccagcagag cauccaccuc gggggcgugu ucgagcucca gcccggggcc      720

agcgucuucg ugaacgugac cgaccccucc caggucagcc acggcaccgg cuucaccucc      780

uucgggcugc ugaagcucug aggacuaguu auaagacuga cuagcccgau gggccuccca      840

acgggcccuc cuccccuccu ugcaccgaga uuaauaaaaa aaaaaaaaaa aaaaaaaaaa      900

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaau gcaucccccc cccccccccc      960

cccccccccc cccccaaagg cucuuuucag agccaccaga auu                       1003


<210>  166
<211>  1084
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  PDCD1 mRNA product opt2

<400>  166
gggagaaagc uuaccaugca gaucccccag gcccccuggc ccgucgucug ggccguccuc       60

cagcucggcu ggcgccccgg cugguuccuc gacucccccg accgccccug gaaccccccc      120

accuucuccc ccgcccuccu cgucgucacc gagggcgaca acgccaccuu caccuguucc      180

uucuccaaca ccuccgaguc cuucguccuc aacugguacc gcaugucccc cuccaaccag      240

accgacaagc ucgccgccuu ccccgaggac cgcucccagc ccggccagga cugccgcuuc      300

cgcgucaccc agcuccccaa cggccgcgac uuccacaugu ccgucguccg cgcccgccgc      360

aacgacuccg gcaccuaccu cugcggcgcc aucucccucg cccccaaggc ccagaucaag      420

gagucccucc gcgccgagcu ccgcgucacc gagcgccgcg ccgagguccc caccgcccac      480

cccucccccu ccccccgccc cgccggccag uuccagaccc ucgucgucgg cgucgucggc      540

ggccuccucg gcucccucgu ccuccucguc uggguccucg ccgucaucug cucccgcgcc      600

gcccgcggca ccaucggcgc ccgccgcacc ggccagcccc ucaaggagga ccccuccgcc      660

guccccgucu ucuccgucga cuacggcgag cucgacuucc aguggcgcga gaagaccccc      720

gagccccccg uccccugcgu ccccgagcag accgaguacg ccaccaucgu cuuccccucc      780

ggcaugggca ccuccucccc cgcccgccgc ggcuccgccg acggcccccg cuccgcccag      840

ccccuccgcc ccgaggacgg ccacugcucc uggccccucu gaggacuagu uauaagacug      900

acuagcccga ugggccuccc aacgggcccu ccuccccucc uugcaccgag auuaauaaaa      960

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa     1020

ugcauccccc cccccccccc cccccccccc ccccccaaag gcucuuuuca gagccaccag     1080

aauu                                                                  1084


<210>  167
<211>  667
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  PDCD1(1-149) mRNA product opt2

<400>  167
gggagaaagc uuaccaugca gaucccccag gcccccuggc ccgucgucug ggccguccuc       60

cagcucggcu ggcgccccgg cugguuccuc gacucccccg accgccccug gaaccccccc      120

accuucuccc ccgcccuccu cgucgucacc gagggcgaca acgccaccuu caccuguucc      180

uucuccaaca ccuccgaguc cuucguccuc aacugguacc gcaugucccc cuccaaccag      240

accgacaagc ucgccgccuu ccccgaggac cgcucccagc ccggccagga cugccgcuuc      300

cgcgucaccc agcuccccaa cggccgcgac uuccacaugu ccgucguccg cgcccgccgc      360

aacgacuccg gcaccuaccu cugcggcgcc aucucccucg cccccaaggc ccagaucaag      420

gagucccucc gcgccgagcu ccgcgucacc gagcgccgcg ccugaggacu aguuauaaga      480

cugacuagcc cgaugggccu cccaacgggc ccuccucccc uccuugcacc gagauuaaua      540

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa      600

aaaugcaucc cccccccccc cccccccccc ccccccccca aaggcucuuu ucagagccac      660

cagaauu                                                                667


<210>  168
<211>  877
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  IL12A mRNA product opt2

<400>  168
gggagaaagc uuaccaugug ccccgcccgc ucccuccucc ucgucgccac ccucguccuc       60

cucgaccacc ucucccucgc ccgcaaccuc cccgucgcca cccccgaccc cggcauguuc      120

cccugccucc accacuccca gaaccuccuc cgcgccgucu ccaacaugcu ccagaaggcc      180

cgccagaccc ucgaguucua ccccugcacc uccgaggaga ucgaccacga ggacaucacc      240

aaggacaaga ccuccaccgu cgaggccugc cucccccucg agcucaccaa gaacgagucc      300

ugccucaacu cccgcgagac cuccuucauc accaacggcu ccugccucgc cucccgcaag      360

accuccuuca ugauggcccu cugccucucc uccaucuacg aggaccucaa gauguaccag      420

gucgaguuca agaccaugaa cgccaagcuc cucauggacc ccaagcgcca gaucuuccuc      480

gaccagaaca ugcucgccgu caucgacgag cucaugcagg cccucaacuu caacuccgag      540

accguccccc agaaguccuc ccucgaggag cccgacuucu acaagaccaa gaucaagcuc      600

ugcauccucc uccacgccuu ccgcauccgc gccgucacca ucgaccgcgu cauguccuac      660

cucaacgccu ccugaggacu aguuauaaga cugacuagcc cgaugggccu cccaacgggc      720

ccuccucccc uccuugcacc gagauuaaua aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa      780

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaugcaucc cccccccccc cccccccccc      840

ccccccccca aaggcucuuu ucagagccac cagaauu                               877


<210>  169
<211>  874
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  IL12A(1-219) mRNA product opt2

<400>  169
gggagaaagc uuaccaugug ccccgcccgc ucccuccucc ucgucgccac ccucguccuc       60

cucgaccacc ucucccucgc ccgcaaccuc cccgucgcca cccccgaccc cggcauguuc      120

cccugccucc accacuccca gaaccuccuc cgcgccgucu ccaacaugcu ccagaaggcc      180

cgccagaccc ucgaguucua ccccugcacc uccgaggaga ucgaccacga ggacaucacc      240

aaggacaaga ccuccaccgu cgaggccugc cucccccucg agcucaccaa gaacgagucc      300

ugccucaacu cccgcgagac cuccuucauc accaacggcu ccugccucgc cucccgcaag      360

accuccuuca ugauggcccu cugccucucc uccaucuacg aggaccucaa gauguaccag      420

gucgaguuca agaccaugaa cgccaagcuc cucauggacc ccaagcgcca gaucuuccuc      480

gaccagaaca ugcucgccgu caucgacgag cucaugcagg cccucaacuu caacuccgag      540

accguccccc agaaguccuc ccucgaggag cccgacuucu acaagaccaa gaucaagcuc      600

ugcauccucc uccacgccuu ccgcauccgc gccgucacca ucgaccgcgu cauguccuac      660

cucaacgccu ccggacuagu uauaagacug acuagcccga ugggccuccc aacgggcccu      720

ccuccccucc uugcaccgag auuaauaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa      780

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa ugcauccccc cccccccccc cccccccccc      840

ccccccaaag gcucuuuuca gagccaccag aauu                                  874


<210>  170
<211>  811
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  IL12A(23-219) mRNA product opt2

<400>  170
gggagaaagc uuacccgcaa ccuccccguc gccacccccg accccggcau guuccccugc       60

cuccaccacu cccagaaccu ccuccgcgcc gucuccaaca ugcuccagaa ggcccgccag      120

acccucgagu ucuaccccug caccuccgag gagaucgacc acgaggacau caccaaggac      180

aagaccucca ccgucgaggc cugccucccc cucgagcuca ccaagaacga guccugccuc      240

aacucccgcg agaccuccuu caucaccaac ggcuccugcc ucgccucccg caagaccucc      300

uucaugaugg cccucugccu cuccuccauc uacgaggacc ucaagaugua ccaggucgag      360

uucaagacca ugaacgccaa gcuccucaug gaccccaagc gccagaucuu ccucgaccag      420

aacaugcucg ccgucaucga cgagcucaug caggcccuca acuucaacuc cgagaccguc      480

ccccagaagu ccucccucga ggagcccgac uucuacaaga ccaagaucaa gcucugcauc      540

cuccuccacg ccuuccgcau ccgcgccguc accaucgacc gcgucauguc cuaccucaac      600

gccuccugag gacuaguuau aagacugacu agcccgaugg gccucccaac gggcccuccu      660

ccccuccuug caccgagauu aauaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa      720

aaaaaaaaaa aaaaaaaaaa aaaaaaaugc aucccccccc cccccccccc cccccccccc      780

cccaaaggcu cuuuucagag ccaccagaau u                                     811


<210>  171
<211>  1204
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  IL12B mRNA product opt2

<400>  171
gggagaaagc uuaccaugug ccaccagcag cucgucaucu ccugguucuc ccucgucuuc       60

cucgccuccc cccucgucgc caucugggag cucaagaagg acgucuacgu cgucgagcuc      120

gacugguacc ccgacgcccc cggcgagaug gucguccuca ccugugacac ccccgaggag      180

gacggcauca ccuggacccu cgaccagucc uccgaggucc ucggcuccgg caagacccuc      240

accauccagg ucaaggaguu cggcgacgcc ggccaguaca ccugucacaa gggcggcgag      300

guccucuccc acucccuccu ccuccuccac aagaaggagg acggcaucug guccaccgac      360

auccucaagg accagaagga gcccaagaac aagaccuucc uccgcugcga ggccaagaac      420

uacuccggcc gcuucaccug uugguggcuc accaccaucu ccaccgaccu caccuucucc      480

gucaaguccu cccgcggcuc cuccgacccc cagggcguca ccuguggcgc cgccacccuc      540

uccgccgagc gcguccgcgg cgacaacaag gaguacgagu acuccgucga gugccaggag      600

gacuccgccu gccccgccgc cgaggagucc cuccccaucg aggucauggu cgacgccguc      660

cacaagcuca aguacgagaa cuacaccucc uccuucuuca uccgcgacau caucaagccc      720

gaccccccca agaaccucca gcucaagccc cucaagaacu cccgccaggu cgaggucucc      780

ugggaguacc ccgacaccug guccaccccc cacuccuacu ucucccucac cuucugcguc      840

cagguccagg gcaaguccaa gcgcgagaag aaggaccgcg ucuucaccga caagaccucc      900

gccaccguca ucugccgcaa gaacgccucc aucuccgucc gcgcccagga ccgcuacuac      960

uccuccuccu gguccgagug ggccuccguc cccugcuccu gaggacuagu uauaagacug     1020

acuagcccga ugggccuccc aacgggcccu ccuccccucc uugcaccgag auuaauaaaa     1080

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa     1140

ugcauccccc cccccccccc cccccccccc ccccccaaag gcucuuuuca gagccaccag     1200

aauu                                                                  1204


<210>  172
<211>  1201
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  IL12B(1-328) mRNA product opt2

<400>  172
gggagaaagc uuaccaugug ccaccagcag cucgucaucu ccugguucuc ccucgucuuc       60

cucgccuccc cccucgucgc caucugggag cucaagaagg acgucuacgu cgucgagcuc      120

gacugguacc ccgacgcccc cggcgagaug gucguccuca ccugugacac ccccgaggag      180

gacggcauca ccuggacccu cgaccagucc uccgaggucc ucggcuccgg caagacccuc      240

accauccagg ucaaggaguu cggcgacgcc ggccaguaca ccugucacaa gggcggcgag      300

guccucuccc acucccuccu ccuccuccac aagaaggagg acggcaucug guccaccgac      360

auccucaagg accagaagga gcccaagaac aagaccuucc uccgcugcga ggccaagaac      420

uacuccggcc gcuucaccug uugguggcuc accaccaucu ccaccgaccu caccuucucc      480

gucaaguccu cccgcggcuc cuccgacccc cagggcguca ccuguggcgc cgccacccuc      540

uccgccgagc gcguccgcgg cgacaacaag gaguacgagu acuccgucga gugccaggag      600

gacuccgccu gccccgccgc cgaggagucc cuccccaucg aggucauggu cgacgccguc      660

cacaagcuca aguacgagaa cuacaccucc uccuucuuca uccgcgacau caucaagccc      720

gaccccccca agaaccucca gcucaagccc cucaagaacu cccgccaggu cgaggucucc      780

ugggaguacc ccgacaccug guccaccccc cacuccuacu ucucccucac cuucugcguc      840

cagguccagg gcaaguccaa gcgcgagaag aaggaccgcg ucuucaccga caagaccucc      900

gccaccguca ucugccgcaa gaacgccucc aucuccgucc gcgcccagga ccgcuacuac      960

uccuccuccu gguccgagug ggccuccguc cccugcuccg gacuaguuau aagacugacu     1020

agcccgaugg gccucccaac gggcccuccu ccccuccuug caccgagauu aauaaaaaaa     1080

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaugc     1140

aucccccccc cccccccccc cccccccccc cccaaaggcu cuuuucagag ccaccagaau     1200

u                                                                     1201


<210>  173
<211>  1138
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  IL12B(23-328) mRNA product opt2

<400>  173
gggagaaagc uuaccaucug ggagcucaag aaggacgucu acgucgucga gcucgacugg       60

uaccccgacg cccccggcga gauggucguc cucaccugug acacccccga ggaggacggc      120

aucaccugga cccucgacca guccuccgag guccucggcu ccggcaagac ccucaccauc      180

caggucaagg aguucggcga cgccggccag uacaccuguc acaagggcgg cgagguccuc      240

ucccacuccc uccuccuccu ccacaagaag gaggacggca ucugguccac cgacauccuc      300

aaggaccaga aggagcccaa gaacaagacc uuccuccgcu gcgaggccaa gaacuacucc      360

ggccgcuuca ccuguuggug gcucaccacc aucuccaccg accucaccuu cuccgucaag      420

uccucccgcg gcuccuccga cccccagggc gucaccugug gcgccgccac ccucuccgcc      480

gagcgcgucc gcggcgacaa caaggaguac gaguacuccg ucgagugcca ggaggacucc      540

gccugccccg ccgccgagga gucccucccc aucgagguca uggucgacgc cguccacaag      600

cucaaguacg agaacuacac cuccuccuuc uucauccgcg acaucaucaa gcccgacccc      660

cccaagaacc uccagcucaa gccccucaag aacucccgcc aggucgaggu cuccugggag      720

uaccccgaca ccugguccac cccccacucc uacuucuccc ucaccuucug cguccagguc      780

cagggcaagu ccaagcgcga gaagaaggac cgcgucuuca ccgacaagac cuccgccacc      840

gucaucugcc gcaagaacgc cuccaucucc guccgcgccc aggaccgcua cuacuccucc      900

uccugguccg agugggccuc cguccccugc uccugaggac uaguuauaag acugacuagc      960

ccgaugggcc ucccaacggg cccuccuccc cuccuugcac cgagauuaau aaaaaaaaaa     1020

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaugcauc     1080

cccccccccc cccccccccc cccccccccc aaaggcucuu uucagagcca ccagaauu       1138


<210>  174
<211>  271
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Linker-sFvCC49-218 mRNA product opt2

<400>  174
gggagaaagc uuaccggcuc caccuccggc uccggcaagc ccggcuccgg cgagggcucc       60

accaagggcg gacuaguuau aagacugacu agcccgaugg gccucccaac gggcccuccu      120

ccccuccuug caccgagauu aauaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa      180

aaaaaaaaaa aaaaaaaaaa aaaaaaaugc aucccccccc cccccccccc cccccccccc      240

cccaaaggcu cuuuucagag ccaccagaau u                                     271


<210>  175
<211>  1849
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  IL12 mRNA product opt2

<400>  175
gggagaaagc uuaccaugug ccaccagcag cucgucaucu ccugguucuc ccucgucuuc       60

cucgccuccc cccucgucgc caucugggag cucaagaagg acgucuacgu cgucgagcuc      120

gacugguacc ccgacgcccc cggcgagaug gucguccuca ccugugacac ccccgaggag      180

gacggcauca ccuggacccu cgaccagucc uccgaggucc ucggcuccgg caagacccuc      240

accauccagg ucaaggaguu cggcgacgcc ggccaguaca ccugucacaa gggcggcgag      300

guccucuccc acucccuccu ccuccuccac aagaaggagg acggcaucug guccaccgac      360

auccucaagg accagaagga gcccaagaac aagaccuucc uccgcugcga ggccaagaac      420

uacuccggcc gcuucaccug uugguggcuc accaccaucu ccaccgaccu caccuucucc      480

gucaaguccu cccgcggcuc cuccgacccc cagggcguca ccuguggcgc cgccacccuc      540

uccgccgagc gcguccgcgg cgacaacaag gaguacgagu acuccgucga gugccaggag      600

gacuccgccu gccccgccgc cgaggagucc cuccccaucg aggucauggu cgacgccguc      660

cacaagcuca aguacgagaa cuacaccucc uccuucuuca uccgcgacau caucaagccc      720

gaccccccca agaaccucca gcucaagccc cucaagaacu cccgccaggu cgaggucucc      780

ugggaguacc ccgacaccug guccaccccc cacuccuacu ucucccucac cuucugcguc      840

cagguccagg gcaaguccaa gcgcgagaag aaggaccgcg ucuucaccga caagaccucc      900

gccaccguca ucugccgcaa gaacgccucc aucuccgucc gcgcccagga ccgcuacuac      960

uccuccuccu gguccgagug ggccuccguc cccugcuccg gcuccaccuc cggcuccggc     1020

aagcccggcu ccggcgaggg cuccaccaag ggccgcaacc uccccgucgc cacccccgac     1080

cccggcaugu uccccugccu ccaccacucc cagaaccucc uccgcgccgu cuccaacaug     1140

cuccagaagg cccgccagac ccucgaguuc uaccccugca ccuccgagga gaucgaccac     1200

gaggacauca ccaaggacaa gaccuccacc gucgaggccu gccucccccu cgagcucacc     1260

aagaacgagu ccugccucaa cucccgcgag accuccuuca ucaccaacgg cuccugccuc     1320

gccucccgca agaccuccuu caugauggcc cucugccucu ccuccaucua cgaggaccuc     1380

aagauguacc aggucgaguu caagaccaug aacgccaagc uccucaugga ccccaagcgc     1440

cagaucuucc ucgaccagaa caugcucgcc gucaucgacg agcucaugca ggcccucaac     1500

uucaacuccg agaccguccc ccagaagucc ucccucgagg agcccgacuu cuacaagacc     1560

aagaucaagc ucugcauccu ccuccacgcc uuccgcaucc gcgccgucac caucgaccgc     1620

gucauguccu accucaacgc cuccugagga cuaguuauaa gacugacuag cccgaugggc     1680

cucccaacgg gcccuccucc ccuccuugca ccgagauuaa uaaaaaaaaa aaaaaaaaaa     1740

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaugcau cccccccccc     1800

cccccccccc cccccccccc caaaggcucu uuucagagcc accagaauu                 1849


<210>  176
<211>  1003
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  CD40LG mRNA product opt2

<400>  176
gggagaaagc uuaccaugau cgagaccuac aaccagaccu ccccccgcuc cgccgccacc       60

ggccucccca ucuccaugaa gaucuucaug uaccuccuca ccgucuuccu caucacccag      120

augaucggcu ccgcccucuu cgccgucuac cuccaccgcc gccucgacaa gaucgaggac      180

gagcgcaacc uccacgagga cuucgucuuc augaagacca uccagcgcug caacaccggc      240

gagcgcuccc ucucccuccu caacugcgag gagaucaagu cccaguucga gggcuucguc      300

aaggacauca ugcucaacaa ggaggagacc aagaaggaga acuccuucga gaugcagaag      360

ggcgaccaga acccccagau cgccgcccac gucaucuccg aggccuccuc caagaccacc      420

uccguccucc agugggccga gaagggcuac uacaccaugu ccaacaaccu cgucacccuc      480

gagaacggca agcagcucac cgucaagcgc cagggccucu acuacaucua cgcccagguc      540

accuucugcu ccaaccgcga ggccuccucc caggcccccu ucaucgccuc ccucugccuc      600

aagucccccg gccgcuucga gcgcauccuc cuccgcgccg ccaacaccca cuccuccgcc      660

aagcccugcg gccagcaguc cauccaccuc ggcggcgucu ucgagcucca gcccggcgcc      720

uccgucuucg ucaacgucac cgaccccucc caggucuccc acggcaccgg cuucaccucc      780

uucggccucc ucaagcucug aggacuaguu auaagacuga cuagcccgau gggccuccca      840

acgggcccuc cuccccuccu ugcaccgaga uuaauaaaaa aaaaaaaaaa aaaaaaaaaa      900

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaau gcaucccccc cccccccccc      960

cccccccccc cccccaaagg cucuuuucag agccaccaga auu                       1003


<210>  177
<211>  1084
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  PDCD1 mRNA product opt3

<400>  177
gggagaaagc uuaccaugca gaucccccaa gccccuuggc caguggucug ggcuguucug       60

cagcucggcu ggagaccggg gugguuccuu gacagccccg auaggccuug gaacccaccc      120

accuuuuccc cugcacuguu ggugguaaca gagggagaca augccacuuu cacgugcucu      180

uuuucaaaca ccagugagag cuucguguua aauugguacc ggaugucccc aucuaaccag      240

acagauaagc uggcggcuuu ucccgaagac cgcucgcagc cuggucaaga uugucgauuc      300

cgugucacuc agcuaccaaa uggcagagac uuucacaugu cagugguuag ggcccggcgc      360

aacgauagcg ggaccuaucu cugcggagca auuagucugg ccccgaaagc ucagauaaag      420

gaaucccuua gagcagagcu gagggugaca gaacggcgcg ccgagguccc caccgcucau      480

ccuucuccaa gcccccgacc ugccggccag uuccaaacuu uggugguagg uguugucggg      540

ggacuccugg gcucccuggu gcucuuagug ugggugcugg cggucaucug uucaagagca      600

gccaggggca caauuggggc ucggcguacc ggacagccac uuaaagagga ccccagugcc      660

guuccggugu uuagcguaga uuacggugaa uuggacuucc aguggcgcga gaagacgccu      720

gaacccccag ugccuugcgu ccccgagcag acugaguaug caaccaucgu guuuccaucu      780

ggcaugggga cauccucacc cgcuagaagg ggaagcgccg auggcccucg gagugcgcaa      840

ccacugcgac cggaagacgg ucacuguucu uggccccuau gaggacuagu uauaagacug      900

acuagcccga ugggccuccc aacgggcccu ccuccccucc uugcaccgag auuaauaaaa      960

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa     1020

ugcauccccc cccccccccc cccccccccc ccccccaaag gcucuuuuca gagccaccag     1080

aauu                                                                  1084


<210>  178
<211>  667
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  PDCD1(1-149) mRNA product opt3

<400>  178
gggagaaagc uuaccaugca gaucccccaa gccccuuggc caguggucug ggcuguucug       60

cagcucggcu ggagaccggg gugguuccuu gacagccccg auaggccuug gaacccaccc      120

accuuuuccc cugcacuguu ggugguaaca gagggagaca augccacuuu cacgugcucu      180

uuuucaaaca ccagugagag cuucguguua aauugguacc ggaugucccc aucuaaccag      240

acagauaagc uggcggcuuu ucccgaagac cgcucgcagc cuggucaaga uugucgauuc      300

cgugucacuc agcuaccaaa uggcagagac uuucacaugu cagugguuag ggcccggcgc      360

aacgauagcg ggaccuaucu cugcggagca auuagucugg ccccgaaagc ucagauaaag      420

gaaucccuua gagcagagcu gagggugaca gaacggcgcg ccugaggacu aguuauaaga      480

cugacuagcc cgaugggccu cccaacgggc ccuccucccc uccuugcacc gagauuaaua      540

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa      600

aaaugcaucc cccccccccc cccccccccc ccccccccca aaggcucuuu ucagagccac      660

cagaauu                                                                667


<210>  179
<211>  877
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  IL12A mRNA product opt3

<400>  179
gggagaaagc uuaccaugug ccccgccaga agccugcucc uuguggcuac ccuggucuug       60

uuagaccacc ugucccuagc aaggaaccuc ccuguugcca caccagaucc gggcauguuc      120

cccugucugc aucacucuca gaaucuucug cgggcggugu caaacauguu gcaaaaggcu      180

cgccagacuc ucgaguuuua cccuugcacg agugaagaga ucgaccauga agauauuacc      240

aaagacaaga caagcacugu agaggccugu cugccacugg aacucaccaa aaaugagucc      300

ugcuuaaacu cucgagagac aucguucaua accaaugggu caugucuggc aagccguaag      360

acaaguuuua ugauggcccu uugcuugucc ucuaucuaug aagaucugaa aauguaccag      420

guggaguuca agacuaugaa cgcuaagcua cucauggacc ccaaaagaca gauuuuucug      480

gaucaaaaua ugcuugcagu caucgacgaa cugaugcagg ccuugaacuu caauagcgag      540

accgugccuc agaaguccuc acucgaggaa ccagauuuuu auaaaacgaa gauuaaacug      600

uguaucuuac ugcacgcuuu caggauacgg gccguuacua ucgaccgcgu gaugaguuac      660

cucaacgcga gcugaggacu aguuauaaga cugacuagcc cgaugggccu cccaacgggc      720

ccuccucccc uccuugcacc gagauuaaua aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa      780

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaugcaucc cccccccccc cccccccccc      840

ccccccccca aaggcucuuu ucagagccac cagaauu                               877


<210>  180
<211>  874
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  IL12A(1-219) mRNA product opt3

<400>  180
gggagaaagc uuaccaugug ccccgccaga agccugcucc uuguggcuac ccuggucuug       60

uuagaccacc ugucccuagc aaggaaccuc ccuguugcca caccagaucc gggcauguuc      120

cccugucugc aucacucuca gaaucuucug cgggcggugu caaacauguu gcaaaaggcu      180

cgccagacuc ucgaguuuua cccuugcacg agugaagaga ucgaccauga agauauuacc      240

aaagacaaga caagcacugu agaggccugu cugccacugg aacucaccaa aaaugagucc      300

ugcuuaaacu cucgagagac aucguucaua accaaugggu caugucuggc aagccguaag      360

acaaguuuua ugauggcccu uugcuugucc ucuaucuaug aagaucugaa aauguaccag      420

guggaguuca agacuaugaa cgcuaagcua cucauggacc ccaaaagaca gauuuuucug      480

gaucaaaaua ugcuugcagu caucgacgaa cugaugcagg ccuugaacuu caauagcgag      540

accgugccuc agaaguccuc acucgaggaa ccagauuuuu auaaaacgaa gauuaaacug      600

uguaucuuac ugcacgcuuu caggauacgg gccguuacua ucgaccgcgu gaugaguuac      660

cucaacgcga gcggacuagu uauaagacug acuagcccga ugggccuccc aacgggcccu      720

ccuccccucc uugcaccgag auuaauaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa      780

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa ugcauccccc cccccccccc cccccccccc      840

ccccccaaag gcucuuuuca gagccaccag aauu                                  874


<210>  181
<211>  811
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  IL12A(23-219) mRNA product opt3

<400>  181
gggagaaagc uuaccaggaa ccucccuguu gccacaccag auccgggcau guuccccugu       60

cugcaucacu cucagaaucu ucugcgggcg gugucaaaca uguugcaaaa ggcucgccag      120

acucucgagu uuuacccuug cacgagugaa gagaucgacc augaagauau uaccaaagac      180

aagacaagca cuguagaggc cugucugcca cuggaacuca ccaaaaauga guccugcuua      240

aacucucgag agacaucguu cauaaccaau gggucauguc uggcaagccg uaagacaagu      300

uuuaugaugg cccuuugcuu guccucuauc uaugaagauc ugaaaaugua ccagguggag      360

uucaagacua ugaacgcuaa gcuacucaug gaccccaaaa gacagauuuu ucuggaucaa      420

aauaugcuug cagucaucga cgaacugaug caggccuuga acuucaauag cgagaccgug      480

ccucagaagu ccucacucga ggaaccagau uuuuauaaaa cgaagauuaa acuguguauc      540

uuacugcacg cuuucaggau acgggccguu acuaucgacc gcgugaugag uuaccucaac      600

gcgagcugag gacuaguuau aagacugacu agcccgaugg gccucccaac gggcccuccu      660

ccccuccuug caccgagauu aauaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa      720

aaaaaaaaaa aaaaaaaaaa aaaaaaaugc aucccccccc cccccccccc cccccccccc      780

cccaaaggcu cuuuucagag ccaccagaau u                                     811


<210>  182
<211>  1204
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  IL12B mRNA product opt3

<400>  182
gggagaaagc uuaccaugug ccaccagcaa cuggugauca gcugguucuc ccucgucuuu       60

cuugccucuc cccugguugc uauuugggag uugaagaaag acguguacgu aguggaauua      120

gauugguauc cugacgcacc aggcgagaug gucgugcuga ccugugauac accggaagag      180

gacgggauaa cuuggacgcu agaucaguca agugaaguuc ucggaagcgg uaagacccug      240

acaauccagg ugaaagaguu cggcgacgcc gggcaguaca cuugccauaa gggaggcgag      300

guccuuuccc acucucuguu gcuccugcau aaaaaggaag augguauuug gucgaccgac      360

auccugaagg aucaaaaaga gcccaagaac aaaacauuuc ucagauguga agcgaagaau      420

uauucaggga gguuuaccug cuggugguua acuacaauua gcaccgaccu gacguucagu      480

gugaaauccu cucggggaag cuccgauccu cagggcguaa cuuguggcgc ugccacccuu      540

ucagcagagc gcguucgagg ggacaacaag gaguacgaau auagugugga gugccaggaa      600

gauagcgccu guccagcugc agaggaaucu uugcccaucg aggucauggu ggacgccgug      660

cacaagcuga aauacgagaa uuauacaucc ucauucuuua uacgugacau cauuaagccu      720

gauccaccca aaaaccuaca gcucaagccu cugaaaaaua gcagacaagu cgaaguuagu      780

ugggaguacc cagacacuug gucuaccccg cauuccuacu ucagccuuac auuuugcgug      840

cagguacagg gaaagucgaa aagggaaaag aaggaucggg uguucaccga caaaacgucu      900

gcuacuguca ucugucgcaa gaacgccucc auuucaguga gagcgcagga uagguauuac      960

aguagcuccu ggucugagug ggcaagcguu cccugcucau gaggacuagu uauaagacug     1020

acuagcccga ugggccuccc aacgggcccu ccuccccucc uugcaccgag auuaauaaaa     1080

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa     1140

ugcauccccc cccccccccc cccccccccc ccccccaaag gcucuuuuca gagccaccag     1200

aauu                                                                  1204


<210>  183
<211>  1201
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  IL12B(1-328) mRNA product opt3

<400>  183
gggagaaagc uuaccaugug ccaccagcaa cuggugauca gcugguucuc ccucgucuuu       60

cuugccucuc cccugguugc uauuugggag uugaagaaag acguguacgu aguggaauua      120

gauugguauc cugacgcacc aggcgagaug gucgugcuga ccugugauac accggaagag      180

gacgggauaa cuuggacgcu agaucaguca agugaaguuc ucggaagcgg uaagacccug      240

acaauccagg ugaaagaguu cggcgacgcc gggcaguaca cuugccauaa gggaggcgag      300

guccuuuccc acucucuguu gcuccugcau aaaaaggaag augguauuug gucgaccgac      360

auccugaagg aucaaaaaga gcccaagaac aaaacauuuc ucagauguga agcgaagaau      420

uauucaggga gguuuaccug cuggugguua acuacaauua gcaccgaccu gacguucagu      480

gugaaauccu cucggggaag cuccgauccu cagggcguaa cuuguggcgc ugccacccuu      540

ucagcagagc gcguucgagg ggacaacaag gaguacgaau auagugugga gugccaggaa      600

gauagcgccu guccagcugc agaggaaucu uugcccaucg aggucauggu ggacgccgug      660

cacaagcuga aauacgagaa uuauacaucc ucauucuuua uacgugacau cauuaagccu      720

gauccaccca aaaaccuaca gcucaagccu cugaaaaaua gcagacaagu cgaaguuagu      780

ugggaguacc cagacacuug gucuaccccg cauuccuacu ucagccuuac auuuugcgug      840

cagguacagg gaaagucgaa aagggaaaag aaggaucggg uguucaccga caaaacgucu      900

gcuacuguca ucugucgcaa gaacgccucc auuucaguga gagcgcagga uagguauuac      960

aguagcuccu ggucugagug ggcaagcguu cccugcucag gacuaguuau aagacugacu     1020

agcccgaugg gccucccaac gggcccuccu ccccuccuug caccgagauu aauaaaaaaa     1080

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaugc     1140

aucccccccc cccccccccc cccccccccc cccaaaggcu cuuuucagag ccaccagaau     1200

u                                                                     1201


<210>  184
<211>  1138
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  IL12B(23-328) mRNA product opt3

<400>  184
gggagaaagc uuaccauuug ggaguugaag aaagacgugu acguagugga auuagauugg       60

uauccugacg caccaggcga gauggucgug cugaccugug auacaccgga agaggacggg      120

auaacuugga cgcuagauca gucaagugaa guucucggaa gcgguaagac ccugacaauc      180

caggugaaag aguucggcga cgccgggcag uacacuugcc auaagggagg cgagguccuu      240

ucccacucuc uguugcuccu gcauaaaaag gaagauggua uuuggucgac cgacauccug      300

aaggaucaaa aagagcccaa gaacaaaaca uuucucagau gugaagcgaa gaauuauuca      360

gggagguuua ccugcuggug guuaacuaca auuagcaccg accugacguu cagugugaaa      420

uccucucggg gaagcuccga uccucagggc guaacuugug gcgcugccac ccuuucagca      480

gagcgcguuc gaggggacaa caaggaguac gaauauagug uggagugcca ggaagauagc      540

gccuguccag cugcagagga aucuuugccc aucgagguca ugguggacgc cgugcacaag      600

cugaaauacg agaauuauac auccucauuc uuuauacgug acaucauuaa gccugaucca      660

cccaaaaacc uacagcucaa gccucugaaa aauagcagac aagucgaagu uaguugggag      720

uacccagaca cuuggucuac cccgcauucc uacuucagcc uuacauuuug cgugcaggua      780

cagggaaagu cgaaaaggga aaagaaggau cggguguuca ccgacaaaac gucugcuacu      840

gucaucuguc gcaagaacgc cuccauuuca gugagagcgc aggauaggua uuacaguagc      900

uccuggucug agugggcaag cguucccugc ucaugaggac uaguuauaag acugacuagc      960

ccgaugggcc ucccaacggg cccuccuccc cuccuugcac cgagauuaau aaaaaaaaaa     1020

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaugcauc     1080

cccccccccc cccccccccc cccccccccc aaaggcucuu uucagagcca ccagaauu       1138


<210>  185
<211>  271
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Linker-sFvCC49-218 mRNA product opt3

<400>  185
gggagaaagc uuaccggcag caccuccggg ucuggaaagc ccgguucagg cgaggggagu       60

acaaaaggag gacuaguuau aagacugacu agcccgaugg gccucccaac gggcccuccu      120

ccccuccuug caccgagauu aauaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa      180

aaaaaaaaaa aaaaaaaaaa aaaaaaaugc aucccccccc cccccccccc cccccccccc      240

cccaaaggcu cuuuucagag ccaccagaau u                                     271


<210>  186
<211>  1849
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  IL12 mRNA product opt3

<400>  186
gggagaaagc uuaccaugug ccaccagcaa cuggugauca gcugguucuc ccucgucuuu       60

cuugccucuc cccugguugc uauuugggag uugaagaaag acguguacgu aguggaauua      120

gauugguauc cugacgcacc aggcgagaug gucgugcuga ccugugauac accggaagag      180

gacgggauaa cuuggacgcu agaucaguca agugaaguuc ucggaagcgg uaagacccug      240

acaauccagg ugaaagaguu cggcgacgcc gggcaguaca cuugccauaa gggaggcgag      300

guccuuuccc acucucuguu gcuccugcau aaaaaggaag augguauuug gucgaccgac      360

auccugaagg aucaaaaaga gcccaagaac aaaacauuuc ucagauguga agcgaagaau      420

uauucaggga gguuuaccug cuggugguua acuacaauua gcaccgaccu gacguucagu      480

gugaaauccu cucggggaag cuccgauccu cagggcguaa cuuguggcgc ugccacccuu      540

ucagcagagc gcguucgagg ggacaacaag gaguacgaau auagugugga gugccaggaa      600

gauagcgccu guccagcugc agaggaaucu uugcccaucg aggucauggu ggacgccgug      660

cacaagcuga aauacgagaa uuauacaucc ucauucuuua uacgugacau cauuaagccu      720

gauccaccca aaaaccuaca gcucaagccu cugaaaaaua gcagacaagu cgaaguuagu      780

ugggaguacc cagacacuug gucuaccccg cauuccuacu ucagccuuac auuuugcgug      840

cagguacagg gaaagucgaa aagggaaaag aaggaucggg uguucaccga caaaacgucu      900

gcuacuguca ucugucgcaa gaacgccucc auuucaguga gagcgcagga uagguauuac      960

aguagcuccu ggucugagug ggcaagcguu cccugcucag gcagcaccuc cgggucugga     1020

aagcccgguu caggcgaggg gaguacaaaa ggaaggaacc ucccuguugc cacaccagau     1080

ccgggcaugu uccccugucu gcaucacucu cagaaucuuc ugcgggcggu gucaaacaug     1140

uugcaaaagg cucgccagac ucucgaguuu uacccuugca cgagugaaga gaucgaccau     1200

gaagauauua ccaaagacaa gacaagcacu guagaggccu gucugccacu ggaacucacc     1260

aaaaaugagu ccugcuuaaa cucucgagag acaucguuca uaaccaaugg gucaugucug     1320

gcaagccgua agacaaguuu uaugauggcc cuuugcuugu ccucuaucua ugaagaucug     1380

aaaauguacc agguggaguu caagacuaug aacgcuaagc uacucaugga ccccaaaaga     1440

cagauuuuuc uggaucaaaa uaugcuugca gucaucgacg aacugaugca ggccuugaac     1500

uucaauagcg agaccgugcc ucagaagucc ucacucgagg aaccagauuu uuauaaaacg     1560

aagauuaaac uguguaucuu acugcacgcu uucaggauac gggccguuac uaucgaccgc     1620

gugaugaguu accucaacgc gagcugagga cuaguuauaa gacugacuag cccgaugggc     1680

cucccaacgg gcccuccucc ccuccuugca ccgagauuaa uaaaaaaaaa aaaaaaaaaa     1740

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaugcau cccccccccc     1800

cccccccccc cccccccccc caaaggcucu uuucagagcc accagaauu                 1849


<210>  187
<211>  1003
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  CD40LG mRNA product opt3

<400>  187
gggagaaagc uuaccaugau cgagaccuac aaccagacaa gccccagauc cgccgcuacu       60

ggccugccua uuucuaugaa gauauucaug uaucuccuua cgguguuucu gaucacccaa      120

augauugggu cagcauuguu cgccgucuac uuacacaggc ggcuggacaa aaucgaagau      180

gagcgcaauc uacaugaaga cuuuguuuuc augaagacaa uucagcgaug caacacugga      240

gagcguaguc ucagccugcu uaauugugaa gagaucaaau cccaguuuga ggguuucgug      300

aaggauauaa ugcugaacaa agaagagacc aagaaggaaa auucuuuuga gaugcagaaa      360

ggcgaccaaa acccacagau cgcggcucac guaauuucgg aggccucaag caagacaacc      420

aguguguugc agugggcaga aaaaggguau uacacuaugu ccaauaaccu cgucacacug      480

gagaauggaa agcagcugac cgugaaaaga caaggccucu auuacaucua ugcccagguu      540

acguucugcu cuaacaggga agcuagcucc caggcaccgu uuauugccuc auuaugucug      600

aagagucccg gucgguucga gcgcauccuu uugagagcug ccaauacuca uagcucugcg      660

aagccuugcg ggcagcaauc cauacaccug ggaggcgugu uugaacuaca gccaggcgca      720

ucagucuucg ugaacguaac cgaucccagc cagguuaguc augggacagg auuuacuucu      780

uucggucucc ugaaacuuug aggacuaguu auaagacuga cuagcccgau gggccuccca      840

acgggcccuc cuccccuccu ugcaccgaga uuaauaaaaa aaaaaaaaaa aaaaaaaaaa      900

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaau gcaucccccc cccccccccc      960

cccccccccc cccccaaagg cucuuuucag agccaccaga auu                       1003


<210>  188
<211>  1084
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  PDCD1 mRNA product opt3v

<400>  188
gggagaaagc uuaccaugca gaucccucag gcuccuuggc cuguugugug ggcuguucug       60

caacuuggau ggcggccugg cugguuccug gacucuccug acagacccug gaauccucca      120

acauucagcc ccgcucugcu ggugguuacc gagggcgaua augccaccuu caccuguagc      180

uucagcaaca ccagcgagag cuucgugcug aacugguaca gaaugagccc cagcaaccag      240

accgacaagc uggccgccuu uccugaggau agaucucagc ccggccagga cugccgguuc      300

agaguuacac agcugcccaa cggccgggac uuccacaugu cugucguccg ggccagaaga      360

aacgacagcg gcacauaucu gugcggcgcc auuucucugg ccccuaaggc ucagaucaaa      420

gagagccuga gagccgagcu gagagugaca gaaagacggg ccgaagugcc cacagcucac      480

ccuucaccuu cuccaagacc ugccggccag uuccagacac uggucguggg aguuguuggc      540

ggacugcugg gaucucuggu gcugcuuguu ugggugcucg ccgugaucug uagcagagcc      600

gccagaggaa caaucggcgc cagaaggaca ggccagccuc ugaaagagga ucccucugcu      660

guccccgugu ucagcgugga cuauggcgag cuggauuucc aguggcggga aaagacaccc      720

gagccuccag ugccuugugu gccugagcag acagaguacg ccaccaucgu guucccuagc      780

ggcaugggca caucuagccc ugccagaaga ggaucugccg acggaccuag aucugcccag      840

ccucucagac cugaggaugg ccacuguagc uggccucugu aaggacuagu uauaagacug      900

acuagcccga ugggccuccc aacgggcccu ccuccccucc uugcaccgag auuaauaaaa      960

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa     1020

ugcauccccc cccccccccc cccccccccc ccccccaaag gcucuuuuca gagccaccag     1080

aauu                                                                  1084


<210>  189
<211>  667
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  PDCD1(1-149) mRNA product opt3v

<400>  189
gggagaaagc uuaccaugca gaucccucag gcuccuuggc cuguugugug ggcuguucug       60

caacuuggau ggcggccugg cugguuccug gacucuccug acagacccug gaauccucca      120

acauucagcc ccgcucugcu ggugguuacc gagggcgaua augccaccuu caccuguagc      180

uucagcaaca ccagcgagag cuucgugcug aacugguaca gaaugagccc cagcaaccag      240

accgacaagc uggccgccuu uccugaggau agaucucagc ccggccagga cugccgguuc      300

agaguuacac agcugcccaa cggccgggac uuccacaugu cugucguccg ggccagaaga      360

aacgacagcg gcacauaucu gugcggcgcc auuucucugg ccccuaaggc ucagaucaaa      420

gagagccuga gagccgagcu gagagugaca gaaagacggg ccugaggacu aguuauaaga      480

cugacuagcc cgaugggccu cccaacgggc ccuccucccc uccuugcacc gagauuaaua      540

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa      600

aaaugcaucc cccccccccc cccccccccc ccccccccca aaggcucuuu ucagagccac      660

cagaauu                                                                667


<210>  190
<211>  877
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  IL12A mRNA product opt3v

<400>  190
gggagaaagc uuaccaugug cccugccaga ucucugcugc ugguggcuac acuggugcug       60

cuggaucauc ugagccuggc cagaaaccug ccaguggcca cgccugaucc uggcauguuu      120

ccuugucugc accacagcca gaaccugcug agagccgugu ccaacaugcu gcagaaggcc      180

agacagaccc ucgaguucua ccccugcacc agcgaggaaa ucgaccacga ggacaucacc      240

aaggacaaga ccagcaccgu ggaagccugc cugccucugg aacugaccaa gaacgagagc      300

ugccugaaca gccgggaaac cagcuucauc accaacggcu cuugccuggc cuccagaaag      360

accuccuuca ugauggcccu gugccugagc agcaucuacg aggaccugaa gauguaccag      420

gucgaguuca agaccaugaa cgccaagcug cugauggacc ccaagcggca gaucuuccug      480

gaccagaaua ugcuggccgu gaucgacgag cugaugcagg cccugaacuu caacagcgag      540

acagugcccc agaaguccag ccuggaagaa cccgacuucu acaagaccaa gaucaagcug      600

ugcauccugc ugcacgccuu ccggaucaga gccgugacca ucgacagagu gaugagcuac      660

cugaacgccu ccugaggacu aguuauaaga cugacuagcc cgaugggccu cccaacgggc      720

ccuccucccc uccuugcacc gagauuaaua aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa      780

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaugcaucc cccccccccc cccccccccc      840

ccccccccca aaggcucuuu ucagagccac cagaauu                               877


<210>  191
<211>  874
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  IL12A(1-219) mRNA product opt3v

<400>  191
gggagaaagc uuaccaugug cccugccaga ucucugcugc ugguggcuac acuggugcug       60

cuggaucauc ugagccuggc cagaaaccug ccaguggcca cgccugaucc uggcauguuu      120

ccuugucugc accacagcca gaaccugcug agagccgugu ccaacaugcu gcagaaggcc      180

agacagaccc ucgaguucua ccccugcacc agcgaggaaa ucgaccacga ggacaucacc      240

aaggacaaga ccagcaccgu ggaagccugc cugccucugg aacugaccaa gaacgagagc      300

ugccugaaca gccgggaaac cagcuucauc accaacggcu cuugccuggc cuccagaaag      360

accuccuuca ugauggcccu gugccugagc agcaucuacg aggaccugaa gauguaccag      420

gucgaguuca agaccaugaa cgccaagcug cugauggacc ccaagcggca gaucuuccug      480

gaccagaaua ugcuggccgu gaucgacgag cugaugcagg cccugaacuu caacagcgag      540

acagugcccc agaaguccag ccuggaagaa cccgacuucu acaagaccaa gaucaagcug      600

ugcauccugc ugcacgccuu ccggaucaga gccgugacca ucgacagagu gaugagcuac      660

cugaacgccu ccggacuagu uauaagacug acuagcccga ugggccuccc aacgggcccu      720

ccuccccucc uugcaccgag auuaauaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa      780

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa ugcauccccc cccccccccc cccccccccc      840

ccccccaaag gcucuuuuca gagccaccag aauu                                  874


<210>  192
<211>  811
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  IL12A(23-219) mRNA product opt3v

<400>  192
gggagaaagc uuaccagaaa ccugccagug gccacgccug auccuggcau guuuccuugu       60

cugcaccaca gccagaaccu gcugagagcc guguccaaca ugcugcagaa ggccagacag      120

acccucgagu ucuaccccug caccagcgag gaaaucgacc acgaggacau caccaaggac      180

aagaccagca ccguggaagc cugccugccu cuggaacuga ccaagaacga gagcugccug      240

aacagccggg aaaccagcuu caucaccaac ggcucuugcc uggccuccag aaagaccucc      300

uucaugaugg cccugugccu gagcagcauc uacgaggacc ugaagaugua ccaggucgag      360

uucaagacca ugaacgccaa gcugcugaug gaccccaagc ggcagaucuu ccuggaccag      420

aauaugcugg ccgugaucga cgagcugaug caggcccuga acuucaacag cgagacagug      480

ccccagaagu ccagccugga agaacccgac uucuacaaga ccaagaucaa gcugugcauc      540

cugcugcacg ccuuccggau cagagccgug accaucgaca gagugaugag cuaccugaac      600

gccuccugag gacuaguuau aagacugacu agcccgaugg gccucccaac gggcccuccu      660

ccccuccuug caccgagauu aauaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa      720

aaaaaaaaaa aaaaaaaaaa aaaaaaaugc aucccccccc cccccccccc cccccccccc      780

cccaaaggcu cuuuucagag ccaccagaau u                                     811


<210>  193
<211>  1204
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  IL12B mRNA product opt3v

<400>  193
gggagaaagc uuaccaugug ucaccagcag cuggucauca gcugguucag ccugguguuc       60

cuggccucuc cucugguggc caucugggag cugaagaaag acguguacgu gguggaacug      120

gacugguauc ccgaugcucc uggcgagaug guggugcuga ccugcgauac cccugaagag      180

gacggcauca ccuggacacu ggaucagucu agcgaggugc ucggcagcgg caagacccug      240

accauccaag ugaaagaguu uggcgacgcc ggccaguaca ccugucacaa aggcggagaa      300

gugcugagcc acagccugcu gcugcuccac aagaaagagg auggcauuug gagcaccgac      360

auccugaagg accagaaaga gcccaagaac aagaccuucc ugagaugcga ggccaagaac      420

uacagcggcc gguucacaug uugguggcug accaccauca gcaccgaccu gaccuucagc      480

gugaagucca gcagaggcag cagugauccu cagggcguua cauguggcgc cgcuacacug      540

ucugccgaaa gagugcgggg cgacaacaaa gaauacgagu acagcgugga augccaagag      600

gacagcgccu guccagccgc cgaagagucu cugccuaucg aagugauggu ggacgccgug      660

cacaagcuga aguacgagaa cuacaccucc agcuuuuuca uccgggacau caucaagccc      720

gauccuccaa agaaccugca gcugaagccu cugaagaaca gcagacaggu ggaagugucc      780

ugggaguacc ccgacaccug gucuacaccc cacagcuacu ucagccugac cuuuugcgug      840

caagugcagg gcaaguccaa gcgcgagaaa aaggaccggg uguucaccga caagaccagc      900

gccaccguga ucugcagaaa gaacgccagc aucagcguca gagcccagga ccgguacuac      960

agcagcucuu ggagcgaaug ggccagcgug ccauguagcu aaggacuagu uauaagacug     1020

acuagcccga ugggccuccc aacgggcccu ccuccccucc uugcaccgag auuaauaaaa     1080

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa     1140

ugcauccccc cccccccccc cccccccccc ccccccaaag gcucuuuuca gagccaccag     1200

aauu                                                                  1204


<210>  194
<211>  1201
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  IL12B(1-328) mRNA product opt3v

<400>  194
gggagaaagc uuaccaugug ucaccagcag cuggucauca gcugguucag ccugguguuc       60

cuggccucuc cucugguggc caucugggag cugaagaaag acguguacgu gguggaacug      120

gacugguauc ccgaugcucc uggcgagaug guggugcuga ccugcgauac cccugaagag      180

gacggcauca ccuggacacu ggaucagucu agcgaggugc ucggcagcgg caagacccug      240

accauccaag ugaaagaguu uggcgacgcc ggccaguaca ccugucacaa aggcggagaa      300

gugcugagcc acagccugcu gcugcuccac aagaaagagg auggcauuug gagcaccgac      360

auccugaagg accagaaaga gcccaagaac aagaccuucc ugagaugcga ggccaagaac      420

uacagcggcc gguucacaug uugguggcug accaccauca gcaccgaccu gaccuucagc      480

gugaagucca gcagaggcag cagugauccu cagggcguua cauguggcgc cgcuacacug      540

ucugccgaaa gagugcgggg cgacaacaaa gaauacgagu acagcgugga augccaagag      600

gacagcgccu guccagccgc cgaagagucu cugccuaucg aagugauggu ggacgccgug      660

cacaagcuga aguacgagaa cuacaccucc agcuuuuuca uccgggacau caucaagccc      720

gauccuccaa agaaccugca gcugaagccu cugaagaaca gcagacaggu ggaagugucc      780

ugggaguacc ccgacaccug gucuacaccc cacagcuacu ucagccugac cuuuugcgug      840

caagugcagg gcaaguccaa gcgcgagaaa aaggaccggg uguucaccga caagaccagc      900

gccaccguga ucugcagaaa gaacgccagc aucagcguca gagcccagga ccgguacuac      960

agcagcucuu ggagcgaaug ggccagcgug ccauguagcg gacuaguuau aagacugacu     1020

agcccgaugg gccucccaac gggcccuccu ccccuccuug caccgagauu aauaaaaaaa     1080

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaugc     1140

aucccccccc cccccccccc cccccccccc cccaaaggcu cuuuucagag ccaccagaau     1200

u                                                                     1201


<210>  195
<211>  1138
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  IL12B(23-328) mRNA product opt3v

<400>  195
gggagaaagc uuaccaucug ggagcugaag aaagacgugu acguggugga acuggacugg       60

uaucccgaug cuccuggcga gaugguggug cugaccugcg auaccccuga agaggacggc      120

aucaccugga cacuggauca gucuagcgag gugcucggca gcggcaagac ccugaccauc      180

caagugaaag aguuuggcga cgccggccag uacaccuguc acaaaggcgg agaagugcug      240

agccacagcc ugcugcugcu ccacaagaaa gaggauggca uuuggagcac cgacauccug      300

aaggaccaga aagagcccaa gaacaagacc uuccugagau gcgaggccaa gaacuacagc      360

ggccgguuca cauguuggug gcugaccacc aucagcaccg accugaccuu cagcgugaag      420

uccagcagag gcagcaguga uccucagggc guuacaugug gcgccgcuac acugucugcc      480

gaaagagugc ggggcgacaa caaagaauac gaguacagcg uggaaugcca agaggacagc      540

gccuguccag ccgccgaaga gucucugccu aucgaaguga ugguggacgc cgugcacaag      600

cugaaguacg agaacuacac cuccagcuuu uucauccggg acaucaucaa gcccgauccu      660

ccaaagaacc ugcagcugaa gccucugaag aacagcagac agguggaagu guccugggag      720

uaccccgaca ccuggucuac accccacagc uacuucagcc ugaccuuuug cgugcaagug      780

cagggcaagu ccaagcgcga gaaaaaggac cggguguuca ccgacaagac cagcgccacc      840

gugaucugca gaaagaacgc cagcaucagc gucagagccc aggaccggua cuacagcagc      900

ucuuggagcg aaugggccag cgugccaugu agcuaaggac uaguuauaag acugacuagc      960

ccgaugggcc ucccaacggg cccuccuccc cuccuugcac cgagauuaau aaaaaaaaaa     1020

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaugcauc     1080

cccccccccc cccccccccc cccccccccc aaaggcucuu uucagagcca ccagaauu       1138


<210>  196
<211>  271
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Linker-sFvCC49-218 mRNA product opt3v

<400>  196
gggagaaagc uuaccggcuc uacaucuggc ucuggcaaac cuggaucugg cgagggcucu       60

acaaagggcg gacuaguuau aagacugacu agcccgaugg gccucccaac gggcccuccu      120

ccccuccuug caccgagauu aauaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa      180

aaaaaaaaaa aaaaaaaaaa aaaaaaaugc aucccccccc cccccccccc cccccccccc      240

cccaaaggcu cuuuucagag ccaccagaau u                                     271


<210>  197
<211>  1849
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  IL12 mRNA product opt3v

<400>  197
gggagaaagc uuaccaugug ucaccagcag cuggucauca gcugguucag ccugguguuc       60

cuggccucuc cucugguggc caucugggag cugaagaaag acguguacgu gguggaacug      120

gacugguauc ccgaugcucc uggcgagaug guggugcuga ccugcgauac cccugaagag      180

gacggcauca ccuggacacu ggaucagucu agcgaggugc ucggcagcgg caagacccug      240

accauccaag ugaaagaguu uggcgacgcc ggccaguaca ccugucacaa aggcggagaa      300

gugcugagcc acagccugcu gcugcuccac aagaaagagg auggcauuug gagcaccgac      360

auccugaagg accagaaaga gcccaagaac aagaccuucc ugagaugcga ggccaagaac      420

uacagcggcc gguucacaug uugguggcug accaccauca gcaccgaccu gaccuucagc      480

gugaagucca gcagaggcag cagugauccu cagggcguua cauguggcgc cgcuacacug      540

ucugccgaaa gagugcgggg cgacaacaaa gaauacgagu acagcgugga augccaagag      600

gacagcgccu guccagccgc cgaagagucu cugccuaucg aagugauggu ggacgccgug      660

cacaagcuga aguacgagaa cuacaccucc agcuuuuuca uccgggacau caucaagccc      720

gauccuccaa agaaccugca gcugaagccu cugaagaaca gcagacaggu ggaagugucc      780

ugggaguacc ccgacaccug gucuacaccc cacagcuacu ucagccugac cuuuugcgug      840

caagugcagg gcaaguccaa gcgcgagaaa aaggaccggg uguucaccga caagaccagc      900

gccaccguga ucugcagaaa gaacgccagc aucagcguca gagcccagga ccgguacuac      960

agcagcucuu ggagcgaaug ggccagcgug ccauguagcg gcucuacauc uggcucuggc     1020

aaaccuggau cuggcgaggg cucuacaaag ggcagaaacc ugccaguggc cacgccugau     1080

ccuggcaugu uuccuugucu gcaccacagc cagaaccugc ugagagccgu guccaacaug     1140

cugcagaagg ccagacagac ccucgaguuc uaccccugca ccagcgagga aaucgaccac     1200

gaggacauca ccaaggacaa gaccagcacc guggaagccu gccugccucu ggaacugacc     1260

aagaacgaga gcugccugaa cagccgggaa accagcuuca ucaccaacgg cucuugccug     1320

gccuccagaa agaccuccuu caugauggcc cugugccuga gcagcaucua cgaggaccug     1380

aagauguacc aggucgaguu caagaccaug aacgccaagc ugcugaugga ccccaagcgg     1440

cagaucuucc uggaccagaa uaugcuggcc gugaucgacg agcugaugca ggcccugaac     1500

uucaacagcg agacagugcc ccagaagucc agccuggaag aacccgacuu cuacaagacc     1560

aagaucaagc ugugcauccu gcugcacgcc uuccggauca gagccgugac caucgacaga     1620

gugaugagcu accugaacgc cuccugagga cuaguuauaa gacugacuag cccgaugggc     1680

cucccaacgg gcccuccucc ccuccuugca ccgagauuaa uaaaaaaaaa aaaaaaaaaa     1740

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaugcau cccccccccc     1800

cccccccccc cccccccccc caaaggcucu uuucagagcc accagaauu                 1849


<210>  198
<211>  1003
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  CD40LG mRNA product opt3v

<400>  198
gggagaaagc uuaccaugau cgagacauac aaccagacaa gccccagaag cgccgccaca       60

ggacugccua ucagcaugaa gaucuuuaug uaccugcuga ccguguuccu gaucacccag      120

augaucggca gcgcccuguu ugccguguac cugcacagac ggcuggacaa gaucgaggac      180

gagagaaacc ugcacgagga cuucguguuc augaagacca uccagcggug caacaccggc      240

gagagaaguc ugagccugcu gaacugcgag gaaaucaaga gccaguucga gggcuucgug      300

aaggacauca ugcugaacaa agaggaaacg aagaaagaaa acuccuucga gaugcagaag      360

ggcgaccaga auccucagau cgccgcucac gugaucagcg aggccagcag caagacaaca      420

agcgugcugc agugggccga gaagggcuac uacaccauga gcaacaaccu ggucacccug      480

gaaaacggca agcagcugac agugaagcgg cagggccugu acuacaucua cgcccaagug      540

accuucugca gcaacagaga ggccagcucu caggccccuu uuaucgccag ccugugccug      600

aaguccccug gcagauucga gcggauucug cugagagccg ccaacacaca cagcagcgcc      660

aaaccuugug gccagcaguc uauucaccuc ggcggagugu uugagcugca gccuggcgca      720

agcguguucg ugaaugugac agacccuagc cagguguccc acggcaccgg cuuuacaucu      780

uucggacugc ugaagcugug aggacuaguu auaagacuga cuagcccgau gggccuccca      840

acgggcccuc cuccccuccu ugcaccgaga uuaauaaaaa aaaaaaaaaa aaaaaaaaaa      900

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaau gcaucccccc cccccccccc      960

cccccccccc cccccaaagg cucuuuucag agccaccaga auu                       1003


<210>  199
<211>  1084
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  PDCD1 mRNA product opt4

<400>  199
gggagaaagc uuaccaugca gaucccccag gcccccuggc ccguggugug ggccgugcug       60

cagcugggcu ggagacccgg cugguuccug gacagccccg acagacccug gaaccccccc      120

accuucagcc ccgcccugcu gguggugacc gagggcgaca acgccaccuu caccuguagc      180

uucagcaaca ccagcgagag cuucgugcug aacugguaca gaaugagccc cagcaaccag      240

accgacaagc uggccgccuu ccccgaggac agaagccagc ccggccagga cugcagauuc      300

agagugaccc agcugcccaa cggcagagac uuccacauga gcguggugag agccagaaga      360

aacgacagcg gcaccuaccu gugcggcgcc aucagccugg cccccaaggc ccagaucaag      420

gagagccuga gagccgagcu gagagugacc gagagaaggg ccgaggugcc caccgcccac      480

cccagcccca gccccagacc cgccggccag uuccagaccc uggugguggg cguggugggc      540

ggccugcugg gcagccuggu gcugcuggug ugggugcugg ccgugaucug cagcagagcc      600

gccagaggca ccaucggcgc cagaagaacc ggccagcccc ugaaggagga ccccagcgcc      660

gugcccgugu ucagcgugga cuacggcgag cuggacuucc aguggagaga gaagaccccc      720

gagccccccg ugcccugcgu gcccgagcag accgaguacg ccaccaucgu guuccccagc      780

ggcaugggca ccagcagccc cgccagaaga ggcagcgccg acggccccag aagcgcccag      840

ccccugagac ccgaggacgg ccacugcagc uggccccugu gaggacuagu uauaagacug      900

acuagcccga ugggccuccc aacgggcccu ccuccccucc uugcaccgag auuaauaaaa      960

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa     1020

ugcauccccc cccccccccc cccccccccc ccccccaaag gcucuuuuca gagccaccag     1080

aauu                                                                  1084


<210>  200
<211>  667
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  PDCD1(1-149) mRNA product opt4

<400>  200
gggagaaagc uuaccaugca gaucccccag gcccccuggc ccguggugug ggccgugcug       60

cagcugggcu ggagacccgg cugguuccug gacagccccg acagacccug gaaccccccc      120

accuucagcc ccgcccugcu gguggugacc gagggcgaca acgccaccuu caccuguagc      180

uucagcaaca ccagcgagag cuucgugcug aacugguaca gaaugagccc cagcaaccag      240

accgacaagc uggccgccuu ccccgaggac agaagccagc ccggccagga cugcagauuc      300

agagugaccc agcugcccaa cggcagagac uuccacauga gcguggugag agccagaaga      360

aacgacagcg gcaccuaccu gugcggcgcc aucagccugg cccccaaggc ccagaucaag      420

gagagccuga gagccgagcu gagagugacc gagagaaggg ccugaggacu aguuauaaga      480

cugacuagcc cgaugggccu cccaacgggc ccuccucccc uccuugcacc gagauuaaua      540

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa      600

aaaugcaucc cccccccccc cccccccccc ccccccccca aaggcucuuu ucagagccac      660

cagaauu                                                                667


<210>  201
<211>  877
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  IL12A mRNA product opt4

<400>  201
gggagaaagc uuaccaugug ccccgccaga agccugcugc ugguggccac ccuggugcug       60

cuggaccacc ugagccuggc cagaaaccug cccguggcca cccccgaccc cggcauguuc      120

cccugccugc accacagcca gaaccugcug agagccguga gcaacaugcu gcagaaggcc      180

agacagaccc uggaguucua ccccugcacc agcgaggaga ucgaccacga ggacaucacc      240

aaggacaaga ccagcaccgu ggaggccugc cugccccugg agcugaccaa gaacgagagc      300

ugccugaaca gcagagagac cagcuucauc accaacggca gcugccuggc cagcagaaag      360

accagcuuca ugauggcccu gugccugagc agcaucuacg aggaccugaa gauguaccag      420

guggaguuca agaccaugaa cgccaagcug cugauggacc ccaagagaca gaucuuccug      480

gaccagaaca ugcuggccgu gaucgacgag cugaugcagg cccugaacuu caacagcgag      540

accgugcccc agaagaguag ccuggaggag cccgacuucu acaagaccaa gaucaagcug      600

ugcauccugc ugcacgccuu cagaaucaga gccgugacca ucgacagagu gaugagcuac      660

cugaacgcca gcugaggacu aguuauaaga cugacuagcc cgaugggccu cccaacgggc      720

ccuccucccc uccuugcacc gagauuaaua aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa      780

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaugcaucc cccccccccc cccccccccc      840

ccccccccca aaggcucuuu ucagagccac cagaauu                               877


<210>  202
<211>  874
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  IL12A(1-219) mRNA product opt4

<400>  202
gggagaaagc uuaccaugug ccccgccaga agccugcugc ugguggccac ccuggugcug       60

cuggaccacc ugagccuggc cagaaaccug cccguggcca cccccgaccc cggcauguuc      120

cccugccugc accacagcca gaaccugcug agagccguga gcaacaugcu gcagaaggcc      180

agacagaccc uggaguucua ccccugcacc agcgaggaga ucgaccacga ggacaucacc      240

aaggacaaga ccagcaccgu ggaggccugc cugccccugg agcugaccaa gaacgagagc      300

ugccugaaca gcagagagac cagcuucauc accaacggca gcugccuggc cagcagaaag      360

accagcuuca ugauggcccu gugccugagc agcaucuacg aggaccugaa gauguaccag      420

guggaguuca agaccaugaa cgccaagcug cugauggacc ccaagagaca gaucuuccug      480

gaccagaaca ugcuggccgu gaucgacgag cugaugcagg cccugaacuu caacagcgag      540

accgugcccc agaagaguag ccuggaggag cccgacuucu acaagaccaa gaucaagcug      600

ugcauccugc ugcacgccuu cagaaucaga gccgugacca ucgacagagu gaugagcuac      660

cugaacgcca gcggacuagu uauaagacug acuagcccga ugggccuccc aacgggcccu      720

ccuccccucc uugcaccgag auuaauaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa      780

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa ugcauccccc cccccccccc cccccccccc      840

ccccccaaag gcucuuuuca gagccaccag aauu                                  874


<210>  203
<211>  811
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  IL12A(23-219) mRNA product opt4

<400>  203
gggagaaagc uuaccagaaa ccugcccgug gccacccccg accccggcau guuccccugc       60

cugcaccaca gccagaaccu gcugagagcc gugagcaaca ugcugcagaa ggccagacag      120

acccuggagu ucuaccccug caccagcgag gagaucgacc acgaggacau caccaaggac      180

aagaccagca ccguggaggc cugccugccc cuggagcuga ccaagaacga gagcugccug      240

aacagcagag agaccagcuu caucaccaac ggcagcugcc uggccagcag aaagaccagc      300

uucaugaugg cccugugccu gagcagcauc uacgaggacc ugaagaugua ccagguggag      360

uucaagacca ugaacgccaa gcugcugaug gaccccaaga gacagaucuu ccuggaccag      420

aacaugcugg ccgugaucga cgagcugaug caggcccuga acuucaacag cgagaccgug      480

ccccagaaga guagccugga ggagcccgac uucuacaaga ccaagaucaa gcugugcauc      540

cugcugcacg ccuucagaau cagagccgug accaucgaca gagugaugag cuaccugaac      600

gccagcugag gacuaguuau aagacugacu agcccgaugg gccucccaac gggcccuccu      660

ccccuccuug caccgagauu aauaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa      720

aaaaaaaaaa aaaaaaaaaa aaaaaaaugc aucccccccc cccccccccc cccccccccc      780

cccaaaggcu cuuuucagag ccaccagaau u                                     811


<210>  204
<211>  1204
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  IL12B mRNA product opt4

<400>  204
gggagaaagc uuaccaugug ccaccagcag cuggugauca gcugguucag ccugguguuc       60

cuggccagcc cccugguggc caucugggag cugaagaagg acguguacgu gguggagcug      120

gacugguacc ccgacgcccc cggcgagaug guggugcuga ccugcgacac ccccgaggag      180

gacggcauca ccuggacccu ggaccagagc agcgaggugc ugggcagcgg caagacccug      240

accauccagg ugaaggaguu cggcgacgcc ggccaguaca ccugucacaa gggcggcgag      300

gugcugagcc acagccugcu gcugcugcac aagaaggagg acggcaucug gagcaccgac      360

auccugaagg accagaagga gcccaagaac aagaccuucc ugagaugcga ggccaagaac      420

uacagcggca gauucaccug uugguggcug accaccauca gcaccgaccu gaccuucagc      480

gugaagagua gcagaggcag cagcgacccc cagggcguga ccugcggcgc cgccacccug      540

agcgccgaga gagugagagg cgacaacaag gaguacgagu acagcgugga gugccaggag      600

gacagcgccu gccccgccgc cgaggagagc cugcccaucg aggugauggu ggacgccgug      660

cacaagcuga aguacgagaa cuacaccagc agcuucuuca ucagagacau caucaagccc      720

gaccccccca agaaccugca gcugaagccc cugaagaaca gcagacaggu ggaggugagc      780

ugggaguacc ccgacaccug gagcaccccc cacagcuacu ucagccugac cuucugcgug      840

cagguucagg gcaagagcaa gagagagaag aaggacagag uguucaccga caagaccagc      900

gccaccguga ucugcagaaa gaacgccagc aucagcguga gagcccagga cagauacuac      960

agcagcagcu ggagcgagug ggccagcgug cccugcagcu gaggacuagu uauaagacug     1020

acuagcccga ugggccuccc aacgggcccu ccuccccucc uugcaccgag auuaauaaaa     1080

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa     1140

ugcauccccc cccccccccc cccccccccc ccccccaaag gcucuuuuca gagccaccag     1200

aauu                                                                  1204


<210>  205
<211>  1201
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  IL12B(1-328) mRNA product opt4

<400>  205
gggagaaagc uuaccaugug ccaccagcag cuggugauca gcugguucag ccugguguuc       60

cuggccagcc cccugguggc caucugggag cugaagaagg acguguacgu gguggagcug      120

gacugguacc ccgacgcccc cggcgagaug guggugcuga ccugcgacac ccccgaggag      180

gacggcauca ccuggacccu ggaccagagc agcgaggugc ugggcagcgg caagacccug      240

accauccagg ugaaggaguu cggcgacgcc ggccaguaca ccugucacaa gggcggcgag      300

gugcugagcc acagccugcu gcugcugcac aagaaggagg acggcaucug gagcaccgac      360

auccugaagg accagaagga gcccaagaac aagaccuucc ugagaugcga ggccaagaac      420

uacagcggca gauucaccug uugguggcug accaccauca gcaccgaccu gaccuucagc      480

gugaagagua gcagaggcag cagcgacccc cagggcguga ccugcggcgc cgccacccug      540

agcgccgaga gagugagagg cgacaacaag gaguacgagu acagcgugga gugccaggag      600

gacagcgccu gccccgccgc cgaggagagc cugcccaucg aggugauggu ggacgccgug      660

cacaagcuga aguacgagaa cuacaccagc agcuucuuca ucagagacau caucaagccc      720

gaccccccca agaaccugca gcugaagccc cugaagaaca gcagacaggu ggaggugagc      780

ugggaguacc ccgacaccug gagcaccccc cacagcuacu ucagccugac cuucugcgug      840

cagguucagg gcaagagcaa gagagagaag aaggacagag uguucaccga caagaccagc      900

gccaccguga ucugcagaaa gaacgccagc aucagcguga gagcccagga cagauacuac      960

agcagcagcu ggagcgagug ggccagcgug cccugcagcg gacuaguuau aagacugacu     1020

agcccgaugg gccucccaac gggcccuccu ccccuccuug caccgagauu aauaaaaaaa     1080

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaugc     1140

aucccccccc cccccccccc cccccccccc cccaaaggcu cuuuucagag ccaccagaau     1200

u                                                                     1201


<210>  206
<211>  1138
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  IL12B(23-328) mRNA product opt4

<400>  206
gggagaaagc uuaccaucug ggagcugaag aaggacgugu acguggugga gcuggacugg       60

uaccccgacg cccccggcga gaugguggug cugaccugcg acacccccga ggaggacggc      120

aucaccugga cccuggacca gagcagcgag gugcugggca gcggcaagac ccugaccauc      180

caggugaagg aguucggcga cgccggccag uacaccuguc acaagggcgg cgaggugcug      240

agccacagcc ugcugcugcu gcacaagaag gaggacggca ucuggagcac cgacauccug      300

aaggaccaga aggagcccaa gaacaagacc uuccugagau gcgaggccaa gaacuacagc      360

ggcagauuca ccuguuggug gcugaccacc aucagcaccg accugaccuu cagcgugaag      420

aguagcagag gcagcagcga cccccagggc gugaccugcg gcgccgccac ccugagcgcc      480

gagagaguga gaggcgacaa caaggaguac gaguacagcg uggagugcca ggaggacagc      540

gccugccccg ccgccgagga gagccugccc aucgagguga ugguggacgc cgugcacaag      600

cugaaguacg agaacuacac cagcagcuuc uucaucagag acaucaucaa gcccgacccc      660

cccaagaacc ugcagcugaa gccccugaag aacagcagac agguggaggu gagcugggag      720

uaccccgaca ccuggagcac cccccacagc uacuucagcc ugaccuucug cgugcagguu      780

cagggcaaga gcaagagaga gaagaaggac agaguguuca ccgacaagac cagcgccacc      840

gugaucugca gaaagaacgc cagcaucagc gugagagccc aggacagaua cuacagcagc      900

agcuggagcg agugggccag cgugcccugc agcugaggac uaguuauaag acugacuagc      960

ccgaugggcc ucccaacggg cccuccuccc cuccuugcac cgagauuaau aaaaaaaaaa     1020

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaugcauc     1080

cccccccccc cccccccccc cccccccccc aaaggcucuu uucagagcca ccagaauu       1138


<210>  207
<211>  271
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Linker-sFvCC49-218 mRNA product opt4

<400>  207
gggagaaagc uuaccggcag caccagcggc agcggcaagc ccggcagcgg cgagggcagc       60

accaagggcg gacuaguuau aagacugacu agcccgaugg gccucccaac gggcccuccu      120

ccccuccuug caccgagauu aauaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa      180

aaaaaaaaaa aaaaaaaaaa aaaaaaaugc aucccccccc cccccccccc cccccccccc      240

cccaaaggcu cuuuucagag ccaccagaau u                                     271


<210>  208
<211>  1849
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  IL12 mRNA product opt4

<400>  208
gggagaaagc uuaccaugug ccaccagcag cuggugauca gcugguucag ccugguguuc       60

cuggccagcc cccugguggc caucugggag cugaagaagg acguguacgu gguggagcug      120

gacugguacc ccgacgcccc cggcgagaug guggugcuga ccugcgacac ccccgaggag      180

gacggcauca ccuggacccu ggaccagagc agcgaggugc ugggcagcgg caagacccug      240

accauccagg ugaaggaguu cggcgacgcc ggccaguaca ccugucacaa gggcggcgag      300

gugcugagcc acagccugcu gcugcugcac aagaaggagg acggcaucug gagcaccgac      360

auccugaagg accagaagga gcccaagaac aagaccuucc ugagaugcga ggccaagaac      420

uacagcggca gauucaccug uugguggcug accaccauca gcaccgaccu gaccuucagc      480

gugaagagua gcagaggcag cagcgacccc cagggcguga ccugcggcgc cgccacccug      540

agcgccgaga gagugagagg cgacaacaag gaguacgagu acagcgugga gugccaggag      600

gacagcgccu gccccgccgc cgaggagagc cugcccaucg aggugauggu ggacgccgug      660

cacaagcuga aguacgagaa cuacaccagc agcuucuuca ucagagacau caucaagccc      720

gaccccccca agaaccugca gcugaagccc cugaagaaca gcagacaggu ggaggugagc      780

ugggaguacc ccgacaccug gagcaccccc cacagcuacu ucagccugac cuucugcgug      840

cagguucagg gcaagagcaa gagagagaag aaggacagag uguucaccga caagaccagc      900

gccaccguga ucugcagaaa gaacgccagc aucagcguga gagcccagga cagauacuac      960

agcagcagcu ggagcgagug ggccagcgug cccugcagcg gcagcaccag cggcagcggc     1020

aagcccggca gcggcgaggg cagcaccaag ggcagaaacc ugcccguggc cacccccgac     1080

cccggcaugu uccccugccu gcaccacagc cagaaccugc ugagagccgu gagcaacaug     1140

cugcagaagg ccagacagac ccuggaguuc uaccccugca ccagcgagga gaucgaccac     1200

gaggacauca ccaaggacaa gaccagcacc guggaggccu gccugccccu ggagcugacc     1260

aagaacgaga gcugccugaa cagcagagag accagcuuca ucaccaacgg cagcugccug     1320

gccagcagaa agaccagcuu caugauggcc cugugccuga gcagcaucua cgaggaccug     1380

aagauguacc agguggaguu caagaccaug aacgccaagc ugcugaugga ccccaagaga     1440

cagaucuucc uggaccagaa caugcuggcc gugaucgacg agcugaugca ggcccugaac     1500

uucaacagcg agaccgugcc ccagaagagu agccuggagg agcccgacuu cuacaagacc     1560

aagaucaagc ugugcauccu gcugcacgcc uucagaauca gagccgugac caucgacaga     1620

gugaugagcu accugaacgc cagcugagga cuaguuauaa gacugacuag cccgaugggc     1680

cucccaacgg gcccuccucc ccuccuugca ccgagauuaa uaaaaaaaaa aaaaaaaaaa     1740

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaugcau cccccccccc     1800

cccccccccc cccccccccc caaaggcucu uuucagagcc accagaauu                 1849


<210>  209
<211>  1003
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  CD40LG mRNA product opt4

<400>  209
gggagaaagc uuaccaugau cgagaccuac aaccagacca gccccagaag cgccgccacc       60

ggccugccca ucagcaugaa gaucuucaug uaccugcuga ccguguuccu gaucacccag      120

augaucggca gcgcccuguu cgccguguac cugcacagaa gacuggacaa gaucgaggac      180

gagagaaacc ugcacgagga cuucguguuc augaagacca uccagagaug caacaccggc      240

gagagaagcc ugagccugcu gaacugcgag gagaucaaga gccaguucga gggcuucgug      300

aaggacauca ugcugaacaa ggaggagacc aagaaggaga acagcuucga gaugcagaag      360

ggcgaccaga acccccagau cgccgcccac gugaucagcg aggccagcag caagaccacc      420

agcgugcugc agugggccga gaagggcuac uacaccauga gcaacaaccu ggugacccug      480

gagaacggca agcagcugac cgugaagaga cagggccugu acuacaucua cgcccaggug      540

accuucugca gcaacagaga ggccagcagc caggcccccu ucaucgccag ccugugccug      600

aagagucccg gcagauucga gagaauccug cugagagccg ccaacaccca cagcagcgcc      660

aagcccugcg gccagcagag cauccaccug ggcggcgugu ucgagcugca gcccggcgcc      720

agcguguucg ugaacgugac cgaccccagc caggugagcc acggcaccgg cuucaccagc      780

uucggccugc ugaagcugug aggacuaguu auaagacuga cuagcccgau gggccuccca      840

acgggcccuc cuccccuccu ugcaccgaga uuaauaaaaa aaaaaaaaaa aaaaaaaaaa      900

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaau gcaucccccc cccccccccc      960

cccccccccc cccccaaagg cucuuuucag agccaccaga auu                       1003


<210>  210
<211>  1084
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  PDCD1 mRNA product opt5

<400>  210
gggagaaagc uuaccaugca gaucccccaa gccccuuggc cgguggucug ggcuguucug       60

cagcucggcu ggagacccgg gugguuccug gacagcccug aucggcccug gaacccuccc      120

accuuuuccc cugcccuucu gguggugaca gagggagaca augcgacguu uaccugcucu      180

uucagcaaca cauccgaauc uuucguccuc aauugguacc gcaugagccc guccaaccag      240

accgauaagc uggcugccuu ucccgaggac agaucucagc cuggccaaga uugucgguuc      300

cgcgugacac agcuucccaa ugggagagac uuucacauga gcguugugcg ggcccgcaga      360

aacgauuccg gaaccuaucu gugcggcgcu auuagccucg ccccuaaagc ucagaucaag      420

gaaucucugc gggccgagcu gcgcgucaca gaaagacggg cggaggugcc caccgcccau      480

ccguccccua gcccccgccc ugcugggcag uuccaaacgc ucguuguggg agucgugggc      540

ggccugcuug ggucucuggu gcuccugguc uggguucuug ccgugauuug uuccagagcu      600

gcccggggaa ccaucggcgc gcgcagaaca gggcagcccc ugaaagagga ccccagcgcc      660

gugccugucu uuucugugga uuacggagaa cucgacuucc aguggcggga gaagaccccg      720

gaacccccug uucccugcgu gccugagcag acagaguaug cuaccauugu cuuucccucc      780

ggcaugggga cgagcucccc ggccagacgc ggaucugcug auggcccucg gagcgcccaa      840

ccccugagac cugaagacgg ccacuguucc uggccccugu gaggacuagu uauaagacug      900

acuagcccga ugggccuccc aacgggcccu ccuccccucc uugcaccgag auuaauaaaa      960

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa     1020

ugcauccccc cccccccccc cccccccccc ccccccaaag gcucuuuuca gagccaccag     1080

aauu                                                                  1084


<210>  211
<211>  667
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  PDCD1(1-149) mRNA product opt5

<400>  211
gggagaaagc uuaccaugca gaucccccaa gccccuuggc cgguggucug ggcuguucug       60

cagcucggcu ggagacccgg gugguuccug gacagcccug aucggcccug gaacccuccc      120

accuuuuccc cugcccuucu gguggugaca gagggagaca augcgacguu uaccugcucu      180

uucagcaaca cauccgaauc uuucguccuc aauugguacc gcaugagccc guccaaccag      240

accgauaagc uggcugccuu ucccgaggac agaucucagc cuggccaaga uugucgguuc      300

cgcgugacac agcuucccaa ugggagagac uuucacauga gcguugugcg ggcccgcaga      360

aacgauuccg gaaccuaucu gugcggcgcu auuagccucg ccccuaaagc ucagaucaag      420

gaaucucugc gggccgagcu gcgcgucaca gaaagacggg cgugaggacu aguuauaaga      480

cugacuagcc cgaugggccu cccaacgggc ccuccucccc uccuugcacc gagauuaaua      540

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa      600

aaaugcaucc cccccccccc cccccccccc ccccccccca aaggcucuuu ucagagccac      660

cagaauu                                                                667


<210>  212
<211>  877
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  IL12A mRNA product opt5

<400>  212
gggagaaagc uuaccaugug ccccgccaga agccugcucc ugguggcuac ccuuguccug       60

cucgaccacc ugucccuugc ccggaaccug ccuguugcga caccggaucc cggcauguuc      120

ccuugucucc aucacucuca gaaucugcug cgcgcuguga gcaacaugcu ccaaaaggcc      180

agacagacgc uggaguuuua ccccugcacc uccgaagaga ucgaccauga agauauuaca      240

aaagacaaga ccucuacagu ggaggccugu cuuccucugg aacucaccaa aaaugagagc      300

ugccugaacu cccgggagac aucuuucauc accaauggga gcugucuugc uucccgcaag      360

acgagcuuua ugauggcccu gugccucucu uccauuuaug aagaucugaa aauguaccag      420

gucgaguuca agaccaugaa cgcuaagcug cucauggacc ccaaaagaca gaucuuucug      480

gaucaaaaua ugcuugccgu gauugacgaa cugaugcagg cgcucaacuu caauagcgag      540

acaguuccuc agaagucuuc ccuggaggaa ccggauuuuu auaaaaccaa gaucaaacuu      600

uguauccugc uccacgccuu ccggauucgc gcugugacaa ucgacagagu caugagcuac      660

cugaacgccu cuugaggacu aguuauaaga cugacuagcc cgaugggccu cccaacgggc      720

ccuccucccc uccuugcacc gagauuaaua aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa      780

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaugcaucc cccccccccc cccccccccc      840

ccccccccca aaggcucuuu ucagagccac cagaauu                               877


<210>  213
<211>  874
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  IL12A(1-219) mRNA product opt5

<400>  213
gggagaaagc uuaccaugug ccccgccaga agccugcucc ugguggcuac ccuuguccug       60

cucgaccacc ugucccuugc ccggaaccug ccuguugcga caccggaucc cggcauguuc      120

ccuugucucc aucacucuca gaaucugcug cgcgcuguga gcaacaugcu ccaaaaggcc      180

agacagacgc uggaguuuua ccccugcacc uccgaagaga ucgaccauga agauauuaca      240

aaagacaaga ccucuacagu ggaggccugu cuuccucugg aacucaccaa aaaugagagc      300

ugccugaacu cccgggagac aucuuucauc accaauggga gcugucuugc uucccgcaag      360

acgagcuuua ugauggcccu gugccucucu uccauuuaug aagaucugaa aauguaccag      420

gucgaguuca agaccaugaa cgcuaagcug cucauggacc ccaaaagaca gaucuuucug      480

gaucaaaaua ugcuugccgu gauugacgaa cugaugcagg cgcucaacuu caauagcgag      540

acaguuccuc agaagucuuc ccuggaggaa ccggauuuuu auaaaaccaa gaucaaacuu      600

uguauccugc uccacgccuu ccggauucgc gcugugacaa ucgacagagu caugagcuac      660

cugaacgccu cuggacuagu uauaagacug acuagcccga ugggccuccc aacgggcccu      720

ccuccccucc uugcaccgag auuaauaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa      780

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa ugcauccccc cccccccccc cccccccccc      840

ccccccaaag gcucuuuuca gagccaccag aauu                                  874


<210>  214
<211>  811
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  IL12A(23-219) mRNA product opt5

<400>  214
gggagaaagc uuacccggaa ccugccuguu gcgacaccgg aucccggcau guucccuugu       60

cuccaucacu cucagaaucu gcugcgcgcu gugagcaaca ugcuccaaaa ggccagacag      120

acgcuggagu uuuaccccug caccuccgaa gagaucgacc augaagauau uacaaaagac      180

aagaccucua caguggaggc cugucuuccu cuggaacuca ccaaaaauga gagcugccug      240

aacucccggg agacaucuuu caucaccaau gggagcuguc uugcuucccg caagacgagc      300

uuuaugaugg cccugugccu cucuuccauu uaugaagauc ugaaaaugua ccaggucgag      360

uucaagacca ugaacgcuaa gcugcucaug gaccccaaaa gacagaucuu ucuggaucaa      420

aauaugcuug ccgugauuga cgaacugaug caggcgcuca acuucaauag cgagacaguu      480

ccucagaagu cuucccugga ggaaccggau uuuuauaaaa ccaagaucaa acuuuguauc      540

cugcuccacg ccuuccggau ucgcgcugug acaaucgaca gagucaugag cuaccugaac      600

gccucuugag gacuaguuau aagacugacu agcccgaugg gccucccaac gggcccuccu      660

ccccuccuug caccgagauu aauaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa      720

aaaaaaaaaa aaaaaaaaaa aaaaaaaugc aucccccccc cccccccccc cccccccccc      780

cccaaaggcu cuuuucagag ccaccagaau u                                     811


<210>  215
<211>  1204
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  IL12B mRNA product opt5

<400>  215
gggagaaagc uuaccaugug ccaccagcaa cuggugauca gcugguucuc ccucgucuuu       60

cuggccucuc cccuuguugc uauuugggag cugaagaaag acguguacgu ggucgaacuc      120

gauugguauc cugacgcccc gggcgagaug gugguucuga ccugugauac acccgaagag      180

gacgggauca cguggacccu ugaucagagc uccgaagugc ugggaucugg caagacacuc      240

accauucagg ucaaagaguu cggggacgcg ggacaguaca caugccauaa gggcggggag      300

gugcugagcc acucccugcu ccugcuucau aaaaaggaag auggaaucug gucuaccgac      360

auucugaagg aucaaaaaga gccuaagaac aaaacauuuc ucagauguga agcuaagaau      420

uauagcggcc gguuuaccug cugguggcug acgaccaucu ccacagaccu uaccuucagc      480

guuaaaucuu cccgcggcag cucugauccc caggggguga cauguggagc cgccacccug      540

uccgcugaga gaguccgggg cgacaacaag gaguacgaau auagcgugga gugccaggaa      600

gauucugccu guccugcugc cgaggaaucc cuccccaucg aggugauggu cgacgcgguu      660

cacaagcuga aauacgagaa uuauacgagc uccuucuuua uucgcgacau cauuaagccu      720

gauccgccca aaaaccugca gcucaagccu cugaaaaauu cuagacaagu ggaagugagc      780

ugggaguacc ccgacacaug guccaccccu cauagcuacu ucucucuuac auuuugcguc      840

caggugcagg ggaaguccaa acgggaaaag aaggaucgcg uuuucaccga caaaaccagc      900

gccacaguga ucuguagaaa gaacgcuucu auuagcgucc gggcccagga ucgcuauuac      960

uccucuagcu gguccgagug ggcuagcgug cccugcucuu gaggacuagu uauaagacug     1020

acuagcccga ugggccuccc aacgggcccu ccuccccucc uugcaccgag auuaauaaaa     1080

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa     1140

ugcauccccc cccccccccc cccccccccc ccccccaaag gcucuuuuca gagccaccag     1200

aauu                                                                  1204


<210>  216
<211>  1201
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  IL12B(1-328) mRNA product opt5

<400>  216
gggagaaagc uuaccaugug ccaccagcaa cuggugauca gcugguucuc ccucgucuuu       60

cuggccucuc cccuuguugc uauuugggag cugaagaaag acguguacgu ggucgaacuc      120

gauugguauc cugacgcccc gggcgagaug gugguucuga ccugugauac acccgaagag      180

gacgggauca cguggacccu ugaucagagc uccgaagugc ugggaucugg caagacacuc      240

accauucagg ucaaagaguu cggggacgcg ggacaguaca caugccauaa gggcggggag      300

gugcugagcc acucccugcu ccugcuucau aaaaaggaag auggaaucug gucuaccgac      360

auucugaagg aucaaaaaga gccuaagaac aaaacauuuc ucagauguga agcuaagaau      420

uauagcggcc gguuuaccug cugguggcug acgaccaucu ccacagaccu uaccuucagc      480

guuaaaucuu cccgcggcag cucugauccc caggggguga cauguggagc cgccacccug      540

uccgcugaga gaguccgggg cgacaacaag gaguacgaau auagcgugga gugccaggaa      600

gauucugccu guccugcugc cgaggaaucc cuccccaucg aggugauggu cgacgcgguu      660

cacaagcuga aauacgagaa uuauacgagc uccuucuuua uucgcgacau cauuaagccu      720

gauccgccca aaaaccugca gcucaagccu cugaaaaauu cuagacaagu ggaagugagc      780

ugggaguacc ccgacacaug guccaccccu cauagcuacu ucucucuuac auuuugcguc      840

caggugcagg ggaaguccaa acgggaaaag aaggaucgcg uuuucaccga caaaaccagc      900

gccacaguga ucuguagaaa gaacgcuucu auuagcgucc gggcccagga ucgcuauuac      960

uccucuagcu gguccgagug ggcuagcgug cccugcucug gacuaguuau aagacugacu     1020

agcccgaugg gccucccaac gggcccuccu ccccuccuug caccgagauu aauaaaaaaa     1080

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaugc     1140

aucccccccc cccccccccc cccccccccc cccaaaggcu cuuuucagag ccaccagaau     1200

u                                                                     1201


<210>  217
<211>  1138
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  IL12B(23-328) mRNA product opt5

<400>  217
gggagaaagc uuaccauuug ggagcugaag aaagacgugu acguggucga acucgauugg       60

uauccugacg ccccgggcga gauggugguu cugaccugug auacacccga agaggacggg      120

aucacgugga cccuugauca gagcuccgaa gugcugggau cuggcaagac acucaccauu      180

caggucaaag aguucgggga cgcgggacag uacacaugcc auaagggcgg ggaggugcug      240

agccacuccc ugcuccugcu ucauaaaaag gaagauggaa ucuggucuac cgacauucug      300

aaggaucaaa aagagccuaa gaacaaaaca uuucucagau gugaagcuaa gaauuauagc      360

ggccgguuua ccugcuggug gcugacgacc aucuccacag accuuaccuu cagcguuaaa      420

ucuucccgcg gcagcucuga uccccagggg gugacaugug gagccgccac ccuguccgcu      480

gagagagucc ggggcgacaa caaggaguac gaauauagcg uggagugcca ggaagauucu      540

gccuguccug cugccgagga aucccucccc aucgagguga uggucgacgc gguucacaag      600

cugaaauacg agaauuauac gagcuccuuc uuuauucgcg acaucauuaa gccugauccg      660

cccaaaaacc ugcagcucaa gccucugaaa aauucuagac aaguggaagu gagcugggag      720

uaccccgaca caugguccac cccucauagc uacuucucuc uuacauuuug cguccaggug      780

caggggaagu ccaaacggga aaagaaggau cgcguuuuca ccgacaaaac cagcgccaca      840

gugaucugua gaaagaacgc uucuauuagc guccgggccc aggaucgcua uuacuccucu      900

agcugguccg agugggcuag cgugcccugc ucuugaggac uaguuauaag acugacuagc      960

ccgaugggcc ucccaacggg cccuccuccc cuccuugcac cgagauuaau aaaaaaaaaa     1020

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaugcauc     1080

cccccccccc cccccccccc cccccccccc aaaggcucuu uucagagcca ccagaauu       1138


<210>  218
<211>  271
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Linker-sFvCC49-218 mRNA product opt5

<400>  218
gggagaaagc uuaccggcag caccuccggg ucuggaaagc ccggcagcgg ggagggaucc       60

acaaaaggcg gacuaguuau aagacugacu agcccgaugg gccucccaac gggcccuccu      120

ccccuccuug caccgagauu aauaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa      180

aaaaaaaaaa aaaaaaaaaa aaaaaaaugc aucccccccc cccccccccc cccccccccc      240

cccaaaggcu cuuuucagag ccaccagaau u                                     271


<210>  219
<211>  1849
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  IL12 mRNA product opt5

<400>  219
gggagaaagc uuaccaugug ccaccagcaa cuggugauca gcugguucuc ccucgucuuu       60

cuggccucuc cccuuguugc uauuugggag cugaagaaag acguguacgu ggucgaacuc      120

gauugguauc cugacgcccc gggcgagaug gugguucuga ccugugauac acccgaagag      180

gacgggauca cguggacccu ugaucagagc uccgaagugc ugggaucugg caagacacuc      240

accauucagg ucaaagaguu cggggacgcg ggacaguaca caugccauaa gggcggggag      300

gugcugagcc acucccugcu ccugcuucau aaaaaggaag auggaaucug gucuaccgac      360

auucugaagg aucaaaaaga gccuaagaac aaaacauuuc ucagauguga agcuaagaau      420

uauagcggcc gguuuaccug cugguggcug acgaccaucu ccacagaccu uaccuucagc      480

guuaaaucuu cccgcggcag cucugauccc caggggguga cauguggagc cgccacccug      540

uccgcugaga gaguccgggg cgacaacaag gaguacgaau auagcgugga gugccaggaa      600

gauucugccu guccugcugc cgaggaaucc cuccccaucg aggugauggu cgacgcgguu      660

cacaagcuga aauacgagaa uuauacgagc uccuucuuua uucgcgacau cauuaagccu      720

gauccgccca aaaaccugca gcucaagccu cugaaaaauu cuagacaagu ggaagugagc      780

ugggaguacc ccgacacaug guccaccccu cauagcuacu ucucucuuac auuuugcguc      840

caggugcagg ggaaguccaa acgggaaaag aaggaucgcg uuuucaccga caaaaccagc      900

gccacaguga ucuguagaaa gaacgcuucu auuagcgucc gggcccagga ucgcuauuac      960

uccucuagcu gguccgagug ggcuagcgug cccugcucug gcagcaccuc cgggucugga     1020

aagcccggca gcggggaggg auccacaaaa ggccggaacc ugccuguugc gacaccggau     1080

cccggcaugu ucccuugucu ccaucacucu cagaaucugc ugcgcgcugu gagcaacaug     1140

cuccaaaagg ccagacagac gcuggaguuu uaccccugca ccuccgaaga gaucgaccau     1200

gaagauauua caaaagacaa gaccucuaca guggaggccu gucuuccucu ggaacucacc     1260

aaaaaugaga gcugccugaa cucccgggag acaucuuuca ucaccaaugg gagcugucuu     1320

gcuucccgca agacgagcuu uaugauggcc cugugccucu cuuccauuua ugaagaucug     1380

aaaauguacc aggucgaguu caagaccaug aacgcuaagc ugcucaugga ccccaaaaga     1440

cagaucuuuc uggaucaaaa uaugcuugcc gugauugacg aacugaugca ggcgcucaac     1500

uucaauagcg agacaguucc ucagaagucu ucccuggagg aaccggauuu uuauaaaacc     1560

aagaucaaac uuuguauccu gcuccacgcc uuccggauuc gcgcugugac aaucgacaga     1620

gucaugagcu accugaacgc cucuugagga cuaguuauaa gacugacuag cccgaugggc     1680

cucccaacgg gcccuccucc ccuccuugca ccgagauuaa uaaaaaaaaa aaaaaaaaaa     1740

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaugcau cccccccccc     1800

cccccccccc cccccccccc caaaggcucu uuucagagcc accagaauu                 1849


<210>  220
<211>  1003
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  CD40LG mRNA product opt5

<400>  220
gggagaaagc uuaccaugau cgagaccuac aaccagacaa gccccagauc cgccgcuacg       60

ggccugccua uuucuaugaa gaucuucaug uaucuccuga ccguguuucu uauuacacaa      120

augaucggga gcgcccuguu cgcggucuac cuccaccggc gccuggacaa aauugaagau      180

gagagaaauc uucaugaaga cuuuguuuuc augaagacca uccagcggug caacacagga      240

gagcgcuccc ugucucuccu gaauugugaa gagaucaaaa gccaguuuga gggcuucgug      300

aaggauauua ugcugaacaa agaagagacc aagaaggaaa auuccuuuga gaugcagaaa      360

ggggaccaaa acccgcagau cgcugcccac gugauuucug aggccagcuc caagacaacc      420

agcguccucc agugggcuga aaaaggauau uacacgaugu cuaauaaccu ggugacccuu      480

gagaauggca agcagcugac aguuaaaaga caagggcucu auuacaucua ugcccaggug      540

accuucugcu ccaaccggga agcuagcucu caggcccccu uuauugcguc ccugugucuu      600

aagagcccug gacgcuucga gagaauccug cuccgggccg cuaauacaca uucuuccgcc      660

aagcccugcg gccagcaaag cauucaccug ggcggggucu uugaacugca gccuggagcu      720

uccguguucg uuaacgugac cgaucccucu caggucagcc auggcacggg guuuacaucc      780

uucggacucc ugaaacuuug aggacuaguu auaagacuga cuagcccgau gggccuccca      840

acgggcccuc cuccccuccu ugcaccgaga uuaauaaaaa aaaaaaaaaa aaaaaaaaaa      900

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaau gcaucccccc cccccccccc      960

cccccccccc cccccaaagg cucuuuucag agccaccaga auu                       1003


<210>  221
<211>  1084
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  PDCD1 mRNA product opt6

<400>  221
gggagaaagc uuaccaugca aauaccacaa gcaccauggc caguaguaug ggcuguacua       60

caauuagguu ggcgaccagg augguuuuua gacucaccag aucguccaug gaacccacca      120

acauuuucac cagcauuauu aguaguaaca gaaggagaua augcaaccuu uacauguuca      180

uucaguaaca caucagaaag uuuuguacua aauugguaua gaaugucacc uucaaaucaa      240

acagauaaau uagcagcauu uccagaagau agaucacaac caggacaaga uugcagauuu      300

agaguaacac aauuaccuaa uggacgagac uuucauaugu caguaguaag agcucgacgu      360

aacgauucag gaacauacuu auguggagca auaucauuag caccaaaagc acaaauaaaa      420

gaaucuuuaa gagcagaauu aagaguaaca gaaagacgcg cagaaguacc aacagcacau      480

ccaagcccuu caccacgacc ugcaggacaa uuucaaacau uaguagucgg aguaguagga      540

ggauuauuag guucacuggu auuauuagua uggguauuag caguaauaug cuccagagca      600

gcaagaggaa caauaggagc aagaagaaca ggacaaccau uaaaagaaga cccaucugca      660

guaccaguau uuucaguuga cuauggagaa cuagauuucc aauggaggga aaaaacacca      720

gaaccuccag uuccaugugu accagaacaa acagaauaug caacaauugu auuucccuca      780

ggaaugggaa caucuagucc agcaagaaga ggaucagcug auggaccaag aucagcacaa      840

ccauuaagac cagaagaugg acauuguuca uggccauuau aaggacuagu uauaagacug      900

acuagcccga ugggccuccc aacgggcccu ccuccccucc uugcaccgag auuaauaaaa      960

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa     1020

ugcauccccc cccccccccc cccccccccc ccccccaaag gcucuuuuca gagccaccag     1080

aauu                                                                  1084


<210>  222
<211>  667
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  PDCD1(1-149) mRNA product opt6

<400>  222
gggagaaagc uuaccaugca aauaccacaa gcaccauggc caguaguaug ggcuguacua       60

caauuagguu ggcgaccagg augguuuuua gacucaccag aucguccaug gaacccacca      120

acauuuucac cagcauuauu aguaguaaca gaaggagaua augcaaccuu uacauguuca      180

uucaguaaca caucagaaag uuuuguacua aauugguaua gaaugucacc uucaaaucaa      240

acagauaaau uagcagcauu uccagaagau agaucacaac caggacaaga uugcagauuu      300

agaguaacac aauuaccuaa uggacgagac uuucauaugu caguaguaag agcucgacgu      360

aacgauucag gaacauacuu auguggagca auaucauuag caccaaaagc acaaauaaaa      420

gaaucuuuaa gagcagaauu aagaguaaca gaaagacgcg cauaaggacu aguuauaaga      480

cugacuagcc cgaugggccu cccaacgggc ccuccucccc uccuugcacc gagauuaaua      540

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa      600

aaaugcaucc cccccccccc cccccccccc ccccccccca aaggcucuuu ucagagccac      660

cagaauu                                                                667


<210>  223
<211>  877
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  IL12A mRNA product opt6

<400>  223
gggagaaagc uuaccaugug cccagcaaga ucacuacuac ugguagcaac acugguacua       60

cuagaccacc uaucacucgc cagaaaccuc ccaguagcca caccagaccc aggaauguuc      120

cccugccucc accauuccca aaaccuacua agagcaguau caaacaugcu acaaaaagca      180

agacaaacac uagaguucua uccaugcaca ucagaagaaa uagaccacga agacauaaca      240

aaagacaaaa caucaaccgu agaagcaugc cucccacucg aacucacaaa aaacgaauca      300

ugccuaaacu caagagaaac aucauucaua acaaacggcu caugcuuagc cucaagaaaa      360

acaucauuca ugauggcacu augccucuca uccauauaug aagacuuaaa aauguaccaa      420

guagaauuua aaaccaugaa cgcaaaauua cuaauggacc caaaaagaca aauauuccua      480

gaccaaaaca ugcuagcagu aauagacgaa cuaaugcaag cacuaaacuu caacucagaa      540

accguacccc aaaaaucauc ucuagaagaa ccagacuucu acaaaacaaa aauaaaacua      600

ugcauacuac uacacgccuu cagaauaaga gccgucacaa uagacagagu caugucauac      660

cuaaacgccu cauaaggacu aguuauaaga cugacuagcc cgaugggccu cccaacgggc      720

ccuccucccc uccuugcacc gagauuaaua aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa      780

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaugcaucc cccccccccc cccccccccc      840

ccccccccca aaggcucuuu ucagagccac cagaauu                               877


<210>  224
<211>  874
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  IL12A(1-219) mRNA product opt6

<400>  224
gggagaaagc uuaccaugug cccagcaaga ucacuacuac ugguagcaac acugguacua       60

cuagaccacc uaucacucgc cagaaaccuc ccaguagcca caccagaccc aggaauguuc      120

cccugccucc accauuccca aaaccuacua agagcaguau caaacaugcu acaaaaagca      180

agacaaacac uagaguucua uccaugcaca ucagaagaaa uagaccacga agacauaaca      240

aaagacaaaa caucaaccgu agaagcaugc cucccacucg aacucacaaa aaacgaauca      300

ugccuaaacu caagagaaac aucauucaua acaaacggcu caugcuuagc cucaagaaaa      360

acaucauuca ugauggcacu augccucuca uccauauaug aagacuuaaa aauguaccaa      420

guagaauuua aaaccaugaa cgcaaaauua cuaauggacc caaaaagaca aauauuccua      480

gaccaaaaca ugcuagcagu aauagacgaa cuaaugcaag cacuaaacuu caacucagaa      540

accguacccc aaaaaucauc ucuagaagaa ccagacuucu acaaaacaaa aauaaaacua      600

ugcauacuac uacacgccuu cagaauaaga gccgucacaa uagacagagu caugucauac      660

cuaaacgccu caggacuagu uauaagacug acuagcccga ugggccuccc aacgggcccu      720

ccuccccucc uugcaccgag auuaauaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa      780

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa ugcauccccc cccccccccc cccccccccc      840

ccccccaaag gcucuuuuca gagccaccag aauu                                  874


<210>  225
<211>  811
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  IL12A(23-219) mRNA product opt6

<400>  225
gggagaaagc uuaccagaaa ccucccagua gccacaccag acccaggaau guuccccugc       60

cuccaccauu cccaaaaccu acuaagagca guaucaaaca ugcuacaaaa agcaagacaa      120

acacuagagu ucuauccaug cacaucagaa gaaauagacc acgaagacau aacaaaagac      180

aaaacaucaa ccguagaagc augccuccca cucgaacuca caaaaaacga aucaugccua      240

aacucaagag aaacaucauu cauaacaaac ggcucaugcu uagccucaag aaaaacauca      300

uucaugaugg cacuaugccu cucauccaua uaugaagacu uaaaaaugua ccaaguagaa      360

uuuaaaacca ugaacgcaaa auuacuaaug gacccaaaaa gacaaauauu ccuagaccaa      420

aacaugcuag caguaauaga cgaacuaaug caagcacuaa acuucaacuc agaaaccgua      480

ccccaaaaau caucucuaga agaaccagac uucuacaaaa caaaaauaaa acuaugcaua      540

cuacuacacg ccuucagaau aagagccguc acaauagaca gagucauguc auaccuaaac      600

gccucauaag gacuaguuau aagacugacu agcccgaugg gccucccaac gggcccuccu      660

ccccuccuug caccgagauu aauaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa      720

aaaaaaaaaa aaaaaaaaaa aaaaaaaugc aucccccccc cccccccccc cccccccccc      780

cccaaaggcu cuuuucagag ccaccagaau u                                     811


<210>  226
<211>  1204
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  IL12B mRNA product opt6

<400>  226
gggagaaagc uuaccaugug ccaccaacaa cugguaauau caugguucuc acugguauuc       60

uuggcaucac cccuaguagc aauaugggaa cuaaaaaaag acguauacgu aguagaacua      120

gacugguacc cagacgcacc aggagaaaug guaguauuaa caugcgacac accagaagaa      180

gauggaauaa cuuggacauu agaccaauca agugaaguau uaggaucagg caaaacacua      240

acuauacaag uaaaagaauu uggagacgca ggacaauaca cgugccacaa aggaggcgaa      300

guccuaucac auucacuacu auuauuacac aaaaaagaag acggaaucug gagcacagac      360

auauuaaaag accaaaaaga accaaaaaac aaaacauuuc uaagaugcga agcuaaaaac      420

uauucaggaa gauucacaug cugguggcua acaaccauca guaccgacuu aacauucuca      480

guaaaaucau caagaggauc aucagaccca caaggaguaa cauguggagc agcaacacua      540

agcgcagaaa gaguacgagg agacaacaaa gaauacgaau auucaguaga augucaagaa      600

gacucagcau gcccugcagc agaagaauca uuaccaauag aaguaauggu cgacgcugua      660

cacaaacuaa aauaugaaaa uuacacaagc aguuucuuca uaagagacau aauaaaaccc      720

gacccaccaa aaaaccuaca acuaaaacca uuaaaaaauu caagacaagu agaaguauca      780

ugggaauacc cagauacaug gagcacacca cacaguuacu ucucauuaac auucugcgua      840

caaguacaag gaaaaaguaa aagagaaaaa aaagacagag uauucacaga uaagacuuca      900

gcaacaguaa uaugcagaaa aaacgcaagc auaagcguac gagcacaaga cagauauuac      960

ucaagcucau ggucagaaug ggcaucagua ccauguucau aaggacuagu uauaagacug     1020

acuagcccga ugggccuccc aacgggcccu ccuccccucc uugcaccgag auuaauaaaa     1080

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa     1140

ugcauccccc cccccccccc cccccccccc ccccccaaag gcucuuuuca gagccaccag     1200

aauu                                                                  1204


<210>  227
<211>  1201
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  IL12B(1-328) mRNA product opt6

<400>  227
gggagaaagc uuaccaugug ccaccaacaa cugguaauau caugguucuc acugguauuc       60

uuggcaucac cccuaguagc aauaugggaa cuaaaaaaag acguauacgu aguagaacua      120

gacugguacc cagacgcacc aggagaaaug guaguauuaa caugcgacac accagaagaa      180

gauggaauaa cuuggacauu agaccaauca agugaaguau uaggaucagg caaaacacua      240

acuauacaag uaaaagaauu uggagacgca ggacaauaca cgugccacaa aggaggcgaa      300

guccuaucac auucacuacu auuauuacac aaaaaagaag acggaaucug gagcacagac      360

auauuaaaag accaaaaaga accaaaaaac aaaacauuuc uaagaugcga agcuaaaaac      420

uauucaggaa gauucacaug cugguggcua acaaccauca guaccgacuu aacauucuca      480

guaaaaucau caagaggauc aucagaccca caaggaguaa cauguggagc agcaacacua      540

agcgcagaaa gaguacgagg agacaacaaa gaauacgaau auucaguaga augucaagaa      600

gacucagcau gcccugcagc agaagaauca uuaccaauag aaguaauggu cgacgcugua      660

cacaaacuaa aauaugaaaa uuacacaagc aguuucuuca uaagagacau aauaaaaccc      720

gacccaccaa aaaaccuaca acuaaaacca uuaaaaaauu caagacaagu agaaguauca      780

ugggaauacc cagauacaug gagcacacca cacaguuacu ucucauuaac auucugcgua      840

caaguacaag gaaaaaguaa aagagaaaaa aaagacagag uauucacaga uaagacuuca      900

gcaacaguaa uaugcagaaa aaacgcaagc auaagcguac gagcacaaga cagauauuac      960

ucaagcucau ggucagaaug ggcaucagua ccauguucag gacuaguuau aagacugacu     1020

agcccgaugg gccucccaac gggcccuccu ccccuccuug caccgagauu aauaaaaaaa     1080

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaugc     1140

aucccccccc cccccccccc cccccccccc cccaaaggcu cuuuucagag ccaccagaau     1200

u                                                                     1201


<210>  228
<211>  1138
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  IL12B(23-328) mRNA product opt6

<400>  228
gggagaaagc uuaccauaug ggaacuaaaa aaagacguau acguaguaga acuagacugg       60

uacccagacg caccaggaga aaugguagua uuaacaugcg acacaccaga agaagaugga      120

auaacuugga cauuagacca aucaagugaa guauuaggau caggcaaaac acuaacuaua      180

caaguaaaag aauuuggaga cgcaggacaa uacacgugcc acaaaggagg cgaaguccua      240

ucacauucac uacuauuauu acacaaaaaa gaagacggaa ucuggagcac agacauauua      300

aaagaccaaa aagaaccaaa aaacaaaaca uuucuaagau gcgaagcuaa aaacuauuca      360

ggaagauuca caugcuggug gcuaacaacc aucaguaccg acuuaacauu cucaguaaaa      420

ucaucaagag gaucaucaga cccacaagga guaacaugug gagcagcaac acuaagcgca      480

gaaagaguac gaggagacaa caaagaauac gaauauucag uagaauguca agaagacuca      540

gcaugcccug cagcagaaga aucauuacca auagaaguaa uggucgacgc uguacacaaa      600

cuaaaauaug aaaauuacac aagcaguuuc uucauaagag acauaauaaa acccgaccca      660

ccaaaaaacc uacaacuaaa accauuaaaa aauucaagac aaguagaagu aucaugggaa      720

uacccagaua cauggagcac accacacagu uacuucucau uaacauucug cguacaagua      780

caaggaaaaa guaaaagaga aaaaaaagac agaguauuca cagauaagac uucagcaaca      840

guaauaugca gaaaaaacgc aagcauaagc guacgagcac aagacagaua uuacucaagc      900

ucauggucag aaugggcauc aguaccaugu ucauaaggac uaguuauaag acugacuagc      960

ccgaugggcc ucccaacggg cccuccuccc cuccuugcac cgagauuaau aaaaaaaaaa     1020

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaugcauc     1080

cccccccccc cccccccccc cccccccccc aaaggcucuu uucagagcca ccagaauu       1138


<210>  229
<211>  271
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Linker-sFvCC49-218 mRNA product opt6

<400>  229
gggagaaagc uuaccggaag uacaagugga aguggaaaac caggaagugg agaaggaagu       60

acaaaaggag gacuaguuau aagacugacu agcccgaugg gccucccaac gggcccuccu      120

ccccuccuug caccgagauu aauaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa      180

aaaaaaaaaa aaaaaaaaaa aaaaaaaugc aucccccccc cccccccccc cccccccccc      240

cccaaaggcu cuuuucagag ccaccagaau u                                     271


<210>  230
<211>  1849
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  IL12 mRNA product opt6

<400>  230
gggagaaagc uuaccaugug ccaccaacaa cugguaauau caugguucuc acugguauuc       60

uuggcaucac cccuaguagc aauaugggaa cuaaaaaaag acguauacgu aguagaacua      120

gacugguacc cagacgcacc aggagaaaug guaguauuaa caugcgacac accagaagaa      180

gauggaauaa cuuggacauu agaccaauca agugaaguau uaggaucagg caaaacacua      240

acuauacaag uaaaagaauu uggagacgca ggacaauaca cgugccacaa aggaggcgaa      300

guccuaucac auucacuacu auuauuacac aaaaaagaag acggaaucug gagcacagac      360

auauuaaaag accaaaaaga accaaaaaac aaaacauuuc uaagaugcga agcuaaaaac      420

uauucaggaa gauucacaug cugguggcua acaaccauca guaccgacuu aacauucuca      480

guaaaaucau caagaggauc aucagaccca caaggaguaa cauguggagc agcaacacua      540

agcgcagaaa gaguacgagg agacaacaaa gaauacgaau auucaguaga augucaagaa      600

gacucagcau gcccugcagc agaagaauca uuaccaauag aaguaauggu cgacgcugua      660

cacaaacuaa aauaugaaaa uuacacaagc aguuucuuca uaagagacau aauaaaaccc      720

gacccaccaa aaaaccuaca acuaaaacca uuaaaaaauu caagacaagu agaaguauca      780

ugggaauacc cagauacaug gagcacacca cacaguuacu ucucauuaac auucugcgua      840

caaguacaag gaaaaaguaa aagagaaaaa aaagacagag uauucacaga uaagacuuca      900

gcaacaguaa uaugcagaaa aaacgcaagc auaagcguac gagcacaaga cagauauuac      960

ucaagcucau ggucagaaug ggcaucagua ccauguucag gaaguacaag uggaagugga     1020

aaaccaggaa guggagaagg aaguacaaaa ggaagaaacc ucccaguagc cacaccagac     1080

ccaggaaugu uccccugccu ccaccauucc caaaaccuac uaagagcagu aucaaacaug     1140

cuacaaaaag caagacaaac acuagaguuc uauccaugca caucagaaga aauagaccac     1200

gaagacauaa caaaagacaa aacaucaacc guagaagcau gccucccacu cgaacucaca     1260

aaaaacgaau caugccuaaa cucaagagaa acaucauuca uaacaaacgg cucaugcuua     1320

gccucaagaa aaacaucauu caugauggca cuaugccucu cauccauaua ugaagacuua     1380

aaaauguacc aaguagaauu uaaaaccaug aacgcaaaau uacuaaugga cccaaaaaga     1440

caaauauucc uagaccaaaa caugcuagca guaauagacg aacuaaugca agcacuaaac     1500

uucaacucag aaaccguacc ccaaaaauca ucucuagaag aaccagacuu cuacaaaaca     1560

aaaauaaaac uaugcauacu acuacacgcc uucagaauaa gagccgucac aauagacaga     1620

gucaugucau accuaaacgc cucauaagga cuaguuauaa gacugacuag cccgaugggc     1680

cucccaacgg gcccuccucc ccuccuugca ccgagauuaa uaaaaaaaaa aaaaaaaaaa     1740

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaugcau cccccccccc     1800

cccccccccc cccccccccc caaaggcucu uuucagagcc accagaauu                 1849


<210>  231
<211>  1003
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  CD40LG mRNA product opt6

<400>  231
gggagaaagc uuaccaugau agaaacauau aaucaaacaa gcccaagauc agcagcaaca       60

ggacuaccaa uaucaaugaa aauauucaug uaccuacuca cagucuuccu aauaacacaa      120

augauaggau cugcccuauu ugcaguauac cuacacagaa gacuagauaa aauagaagac      180

gaaagaaacc uacaugaaga cuucguauuc augaaaacaa uacaaagaug caacaccgga      240

gaaagauccc uaucacuacu aaacugcgaa gaaauaaaau cacaauucga aggauucgua      300

aaagacauaa ugcuaaacaa agaagaaaca aaaaaagaaa acucuuucga aaugcaaaaa      360

ggagaccaaa acccacaaau agcugcacac gucauaucag aagcaucauc aaaaacaaca      420

ucaguacuuc aaugggcaga aaaaggauac uauacaaugu caaacaaucu aguaacccua      480

gaaaacggaa aacaacuaac aguaaaaaga caaggacuau acuauauaua cgcacaagua      540

acauucugcu caaacagaga agcaucauca caagcaccau ucaucgcauc acuaugccua      600

aaauccccag gaagauucga acgaauccua cuaagagcag caaacacaca cucaucagca      660

aaaccaugcg gccaacaauc aauacaccua ggaggaguau ucgaacuaca accaggagca      720

ucaguauucg uaaacguaac agaccccuca caaguaagcc acggcacagg auucacauca      780

uuuggacuau uaaaauuaua aggacuaguu auaagacuga cuagcccgau gggccuccca      840

acgggcccuc cuccccuccu ugcaccgaga uuaauaaaaa aaaaaaaaaa aaaaaaaaaa      900

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaau gcaucccccc cccccccccc      960

cccccccccc cccccaaagg cucuuuucag agccaccaga auu                       1003


<210>  232
<211>  1084
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  PDCD1 mRNA product opt7

<400>  232
gggagaaagc uuaccaugca gaucccccaa gccccauggc cgguggucug ggcagugcug       60

cagcucggcu ggaggcccgg gugguuccug gacagcccag aucggcccug gaacccaccc      120

accuuuuccc cagccuugcu gguagugacu gagggugaca augcgaccuu cacgugcagu      180

uuuagcaaca cuuccgaaag uuucguccuc aauugguacc gcaugagccc guccaaccag      240

accgauaagc uggccgcauu ucccgaggac aggagccagc caggccaaga uugucgguuc      300

cgcgugaccc aguugcccaa ugggagggac uuucacaugu ccgugguccg ggcccgcagg      360

aacgauagug gcacuuaucu gugcggugca auuagccucg ccccaaaagc gcagaucaag      420

gaaucccugc gggccgagcu gcgcgugacc gaaaggcggg cagagguacc cacggcccau      480

ccgagcccca guccacgccc cgccgggcag uuccaaacuc ucguggucgg cguggugggc      540

gggcuguugg guucccuggu ccuccuggug uggguacugg cagugauuug uagcagggcc      600

gcgcggggca ccaucggggc ccgcaggacu ggccagccau ugaaagagga ccccuccgca      660

gucccagugu uuagugugga uuacggugaa cucgacuucc aguggcggga gaagaccccg      720

gaacccccag uccccugcgu gccagagcag accgaguaug ccacgauugu auuucccagc      780

gggaugggca cuuccagccc ggcacgcagg ggcagugccg augggccacg guccgcccaa      840

ccccugaggc ccgaagacgg ucacuguagc uggccacugu gaggacuagu uauaagacug      900

acuagcccga ugggccuccc aacgggcccu ccuccccucc uugcaccgag auuaauaaaa      960

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa     1020

ugcauccccc cccccccccc cccccccccc ccccccaaag gcucuuuuca gagccaccag     1080

aauu                                                                  1084


<210>  233
<211>  667
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  PDCD1(1-149) mRNA product opt7

<400>  233
gggagaaagc uuaccaugca gaucccccaa gccccauggc cgguggucug ggcagugcug       60

cagcucggcu ggaggcccgg gugguuccug gacagcccag aucggcccug gaacccaccc      120

accuuuuccc cagccuugcu gguagugacu gagggugaca augcgaccuu cacgugcagu      180

uuuagcaaca cuuccgaaag uuucguccuc aauugguacc gcaugagccc guccaaccag      240

accgauaagc uggccgcauu ucccgaggac aggagccagc caggccaaga uugucgguuc      300

cgcgugaccc aguugcccaa ugggagggac uuucacaugu ccgugguccg ggcccgcagg      360

aacgauagug gcacuuaucu gugcggugca auuagccucg ccccaaaagc gcagaucaag      420

gaaucccugc gggccgagcu gcgcgugacc gaaaggcggg caugaggacu aguuauaaga      480

cugacuagcc cgaugggccu cccaacgggc ccuccucccc uccuugcacc gagauuaaua      540

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa      600

aaaugcaucc cccccccccc cccccccccc ccccccccca aaggcucuuu ucagagccac      660

cagaauu                                                                667


<210>  234
<211>  877
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  IL12A mRNA product opt7

<400>  234
gggagaaagc uuaccaugug ccccgccagg agccugcucc ugguggcaac cuugguccug       60

cucgaccacc uguccuuggc ccggaaccug ccaguggcga cuccggaucc cggcauguuc      120

ccaugucucc aucacaguca gaaucugcug cgcgccguaa gcaacaugcu ccaaaaggca      180

aggcagaccc uggaguuuua ccccugcacg uccgaagaga ucgaccauga agauauuacu      240

aaagacaaga ccaguaccgu ggaggccugu uugccacugg aacucacuaa aaaugagagc      300

ugccugaacu cccgggagac cagcuucauc acgaaugggu ccugucuggc aagucgcaag      360

acuagcuuua ugauggccuu gugccucucc agcauuuaug aagaucugaa aauguaccag      420

gucgaguuca agaccaugaa cgcgaagcug cucauggacc ccaaaaggca gaucuuucug      480

gaucaaaaua uguuggccgu gauugacgaa cugaugcagg cacucaacuu caauagugag      540

acugugccac agaaguccag ccuggaggaa ccggauuuuu auaaaaccaa gaucaaacug      600

uguaucuugc uccacgccuu ccggauucgc gccgucacca ucgacagggu gauguccuac      660

cugaacgcaa guugaggacu aguuauaaga cugacuagcc cgaugggccu cccaacgggc      720

ccuccucccc uccuugcacc gagauuaaua aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa      780

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaugcaucc cccccccccc cccccccccc      840

ccccccccca aaggcucuuu ucagagccac cagaauu                               877


<210>  235
<211>  874
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  IL12A(1-219) mRNA product opt7

<400>  235
gggagaaagc uuaccaugug ccccgccagg agccugcucc ugguggcaac cuugguccug       60

cucgaccacc uguccuuggc ccggaaccug ccaguggcga cuccggaucc cggcauguuc      120

ccaugucucc aucacaguca gaaucugcug cgcgccguaa gcaacaugcu ccaaaaggca      180

aggcagaccc uggaguuuua ccccugcacg uccgaagaga ucgaccauga agauauuacu      240

aaagacaaga ccaguaccgu ggaggccugu uugccacugg aacucacuaa aaaugagagc      300

ugccugaacu cccgggagac cagcuucauc acgaaugggu ccugucuggc aagucgcaag      360

acuagcuuua ugauggccuu gugccucucc agcauuuaug aagaucugaa aauguaccag      420

gucgaguuca agaccaugaa cgcgaagcug cucauggacc ccaaaaggca gaucuuucug      480

gaucaaaaua uguuggccgu gauugacgaa cugaugcagg cacucaacuu caauagugag      540

acugugccac agaaguccag ccuggaggaa ccggauuuuu auaaaaccaa gaucaaacug      600

uguaucuugc uccacgccuu ccggauucgc gccgucacca ucgacagggu gauguccuac      660

cugaacgcaa guggacuagu uauaagacug acuagcccga ugggccuccc aacgggcccu      720

ccuccccucc uugcaccgag auuaauaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa      780

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa ugcauccccc cccccccccc cccccccccc      840

ccccccaaag gcucuuuuca gagccaccag aauu                                  874


<210>  236
<211>  811
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  IL12A(23-219) mRNA product opt7

<400>  236
gggagaaagc uuacccggaa ccugccagug gcgacuccgg aucccggcau guucccaugu       60

cuccaucaca gucagaaucu gcugcgcgcc guaagcaaca ugcuccaaaa ggcaaggcag      120

acccuggagu uuuaccccug cacguccgaa gagaucgacc augaagauau uacuaaagac      180

aagaccagua ccguggaggc cuguuugcca cuggaacuca cuaaaaauga gagcugccug      240

aacucccggg agaccagcuu caucacgaau ggguccuguc uggcaagucg caagacuagc      300

uuuaugaugg ccuugugccu cuccagcauu uaugaagauc ugaaaaugua ccaggucgag      360

uucaagacca ugaacgcgaa gcugcucaug gaccccaaaa ggcagaucuu ucuggaucaa      420

aauauguugg ccgugauuga cgaacugaug caggcacuca acuucaauag ugagacugug      480

ccacagaagu ccagccugga ggaaccggau uuuuauaaaa ccaagaucaa acuguguauc      540

uugcuccacg ccuuccggau ucgcgccguc accaucgaca gggugauguc cuaccugaac      600

gcaaguugag gacuaguuau aagacugacu agcccgaugg gccucccaac gggcccuccu      660

ccccuccuug caccgagauu aauaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa      720

aaaaaaaaaa aaaaaaaaaa aaaaaaaugc aucccccccc cccccccccc cccccccccc      780

cccaaaggcu cuuuucagag ccaccagaau u                                     811


<210>  237
<211>  1204
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  IL12B mRNA product opt7

<400>  237
gggagaaagc uuaccaugug ccaccagcaa cuggugauca gcugguucuc ccucgucuuu       60

cuggccaguc ccuugguggc aauuugggag cugaagaaag acguauacgu ggucgaacuc      120

gauugguauc cagacgcccc gggcgagaug guggugcuga ccugugauac ucccgaagag      180

gacgggauca ccuggacguu ggaucagagc uccgaagucc uggguagugg caagacucuc      240

accauucagg ugaaagaguu cggggacgcg ggccaguaua ccugccauaa ggguggggag      300

guacugagcc acucccugcu ccuguugcau aaaaaggaag auggcaucug gagcacugac      360

auucugaagg aucaaaaaga gccaaagaac aaaaccuuuc ucagguguga agccaagaau      420

uacuccggcc gguucacgug cugguggcug acuaccauca guacugaccu gaccuuuagc      480

gugaaaucca gccgcgggag uuccgauccc caggguguca ccuguggcgc agccacguug      540

agcgcagaga gggugcgcgg ggacaacaag gaguacgaau auuccgugga gugccaggaa      600

gauagugccu guccagcggc cgaggaaagc cuccccaucg aggucauggu ggacgcagua      660

cacaaacuga aguacgagaa uuauacuucc agcuucuuua uucgggacau cauuaagcca      720

gauccgccca aaaaccugca gcucaagcca cugaaaaaua guaggcaagu ggaagucucc      780

ugggaguacc ccgacaccug gagcacucca cauaguuacu ucuccuugac cuuuugcguc      840

caggugcagg gcaagagcaa acgggaaaag aaggaucgcg uguucaccga caaaacuagc      900

gccacgguga ucuguaggaa gaacgccucc auuaguguac gggcacagga ucgcuauuac      960

agcuccagcu ggagugagug ggccuccgug cccugcagcu gaggacuagu uauaagacug     1020

acuagcccga ugggccuccc aacgggcccu ccuccccucc uugcaccgag auuaauaaaa     1080

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa     1140

ugcauccccc cccccccccc cccccccccc ccccccaaag gcucuuuuca gagccaccag     1200

aauu                                                                  1204


<210>  238
<211>  1201
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  IL12B(1-328) mRNA product opt7

<400>  238
gggagaaagc uuaccaugug ccaccagcaa cuggugauca gcugguucuc ccucgucuuu       60

cuggccaguc ccuugguggc aauuugggag cugaagaaag acguauacgu ggucgaacuc      120

gauugguauc cagacgcccc gggcgagaug guggugcuga ccugugauac ucccgaagag      180

gacgggauca ccuggacguu ggaucagagc uccgaagucc uggguagugg caagacucuc      240

accauucagg ugaaagaguu cggggacgcg ggccaguaua ccugccauaa ggguggggag      300

guacugagcc acucccugcu ccuguugcau aaaaaggaag auggcaucug gagcacugac      360

auucugaagg aucaaaaaga gccaaagaac aaaaccuuuc ucagguguga agccaagaau      420

uacuccggcc gguucacgug cugguggcug acuaccauca guacugaccu gaccuuuagc      480

gugaaaucca gccgcgggag uuccgauccc caggguguca ccuguggcgc agccacguug      540

agcgcagaga gggugcgcgg ggacaacaag gaguacgaau auuccgugga gugccaggaa      600

gauagugccu guccagcggc cgaggaaagc cuccccaucg aggucauggu ggacgcagua      660

cacaaacuga aguacgagaa uuauacuucc agcuucuuua uucgggacau cauuaagcca      720

gauccgccca aaaaccugca gcucaagcca cugaaaaaua guaggcaagu ggaagucucc      780

ugggaguacc ccgacaccug gagcacucca cauaguuacu ucuccuugac cuuuugcguc      840

caggugcagg gcaagagcaa acgggaaaag aaggaucgcg uguucaccga caaaacuagc      900

gccacgguga ucuguaggaa gaacgccucc auuaguguac gggcacagga ucgcuauuac      960

agcuccagcu ggagugagug ggccuccgug cccugcagcg gacuaguuau aagacugacu     1020

agcccgaugg gccucccaac gggcccuccu ccccuccuug caccgagauu aauaaaaaaa     1080

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaugc     1140

aucccccccc cccccccccc cccccccccc cccaaaggcu cuuuucagag ccaccagaau     1200

u                                                                     1201


<210>  239
<211>  1138
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  IL12B(23-328) mRNA product opt7

<400>  239
gggagaaagc uuaccauuug ggagcugaag aaagacguau acguggucga acucgauugg       60

uauccagacg ccccgggcga gaugguggug cugaccugug auacucccga agaggacggg      120

aucaccugga cguuggauca gagcuccgaa guccugggua guggcaagac ucucaccauu      180

caggugaaag aguucgggga cgcgggccag uauaccugcc auaagggugg ggagguacug      240

agccacuccc ugcuccuguu gcauaaaaag gaagauggca ucuggagcac ugacauucug      300

aaggaucaaa aagagccaaa gaacaaaacc uuucucaggu gugaagccaa gaauuacucc      360

ggccgguuca cgugcuggug gcugacuacc aucaguacug accugaccuu uagcgugaaa      420

uccagccgcg ggaguuccga uccccagggu gucaccugug gcgcagccac guugagcgca      480

gagagggugc gcggggacaa caaggaguac gaauauuccg uggagugcca ggaagauagu      540

gccuguccag cggccgagga aagccucccc aucgagguca ugguggacgc aguacacaaa      600

cugaaguacg agaauuauac uuccagcuuc uuuauucggg acaucauuaa gccagauccg      660

cccaaaaacc ugcagcucaa gccacugaaa aauaguaggc aaguggaagu cuccugggag      720

uaccccgaca ccuggagcac uccacauagu uacuucuccu ugaccuuuug cguccaggug      780

cagggcaaga gcaaacggga aaagaaggau cgcguguuca ccgacaaaac uagcgccacg      840

gugaucugua ggaagaacgc cuccauuagu guacgggcac aggaucgcua uuacagcucc      900

agcuggagug agugggccuc cgugcccugc agcugaggac uaguuauaag acugacuagc      960

ccgaugggcc ucccaacggg cccuccuccc cuccuugcac cgagauuaau aaaaaaaaaa     1020

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaugcauc     1080

cccccccccc cccccccccc cccccccccc aaaggcucuu uucagagcca ccagaauu       1138


<210>  240
<211>  271
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Linker-sFvCC49-218 mRNA product opt7

<400>  240
gggagaaagc uuaccggcag caccuccggg agugguaagc ccggcagcgg ggagggcucc       60

acuaaaggug gacuaguuau aagacugacu agcccgaugg gccucccaac gggcccuccu      120

ccccuccuug caccgagauu aauaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa      180

aaaaaaaaaa aaaaaaaaaa aaaaaaaugc aucccccccc cccccccccc cccccccccc      240

cccaaaggcu cuuuucagag ccaccagaau u                                     271


<210>  241
<211>  1849
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  IL12 mRNA product opt7

<400>  241
gggagaaagc uuaccaugug ccaccagcaa cuggugauca gcugguucuc ccucgucuuu       60

cuggccaguc ccuugguggc aauuugggag cugaagaaag acguauacgu ggucgaacuc      120

gauugguauc cagacgcccc gggcgagaug guggugcuga ccugugauac ucccgaagag      180

gacgggauca ccuggacguu ggaucagagc uccgaagucc uggguagugg caagacucuc      240

accauucagg ugaaagaguu cggggacgcg ggccaguaua ccugccauaa ggguggggag      300

guacugagcc acucccugcu ccuguugcau aaaaaggaag auggcaucug gagcacugac      360

auucugaagg aucaaaaaga gccaaagaac aaaaccuuuc ucagguguga agccaagaau      420

uacuccggcc gguucacgug cugguggcug acuaccauca guacugaccu gaccuuuagc      480

gugaaaucca gccgcgggag uuccgauccc caggguguca ccuguggcgc agccacguug      540

agcgcagaga gggugcgcgg ggacaacaag gaguacgaau auuccgugga gugccaggaa      600

gauagugccu guccagcggc cgaggaaagc cuccccaucg aggucauggu ggacgcagua      660

cacaaacuga aguacgagaa uuauacuucc agcuucuuua uucgggacau cauuaagcca      720

gauccgccca aaaaccugca gcucaagcca cugaaaaaua guaggcaagu ggaagucucc      780

ugggaguacc ccgacaccug gagcacucca cauaguuacu ucuccuugac cuuuugcguc      840

caggugcagg gcaagagcaa acgggaaaag aaggaucgcg uguucaccga caaaacuagc      900

gccacgguga ucuguaggaa gaacgccucc auuaguguac gggcacagga ucgcuauuac      960

agcuccagcu ggagugagug ggccuccgug cccugcagcg gcagcaccuc cgggaguggu     1020

aagcccggca gcggggaggg cuccacuaaa ggucggaacc ugccaguggc gacuccggau     1080

cccggcaugu ucccaugucu ccaucacagu cagaaucugc ugcgcgccgu aagcaacaug     1140

cuccaaaagg caaggcagac ccuggaguuu uaccccugca cguccgaaga gaucgaccau     1200

gaagauauua cuaaagacaa gaccaguacc guggaggccu guuugccacu ggaacucacu     1260

aaaaaugaga gcugccugaa cucccgggag accagcuuca ucacgaaugg guccugucug     1320

gcaagucgca agacuagcuu uaugauggcc uugugccucu ccagcauuua ugaagaucug     1380

aaaauguacc aggucgaguu caagaccaug aacgcgaagc ugcucaugga ccccaaaagg     1440

cagaucuuuc uggaucaaaa uauguuggcc gugauugacg aacugaugca ggcacucaac     1500

uucaauagug agacugugcc acagaagucc agccuggagg aaccggauuu uuauaaaacc     1560

aagaucaaac uguguaucuu gcuccacgcc uuccggauuc gcgccgucac caucgacagg     1620

gugauguccu accugaacgc aaguugagga cuaguuauaa gacugacuag cccgaugggc     1680

cucccaacgg gcccuccucc ccuccuugca ccgagauuaa uaaaaaaaaa aaaaaaaaaa     1740

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaugcau cccccccccc     1800

cccccccccc cccccccccc caaaggcucu uuucagagcc accagaauu                 1849


<210>  242
<211>  1003
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  CD40LG mRNA product opt7

<400>  242
gggagaaagc uuaccaugau cgagaccuac aaccagacua gccccagguc cgccgcaacc       60

ggccugccaa uuaguaugaa gaucuucaug uaucuccuga cgguguuuuu gauuacucaa      120

augaucggga gcgcccuguu cgcggucuac cuccaccggc gccuggacaa aauugaagau      180

gagaggaauu ugcaugaaga cuuuguguuc augaagacca uccagcggug caacaccggu      240

gagcgcuccc ugagucuccu gaauugugaa gagaucaaaa gccaguuuga gggcuucgua      300

aaggauauua ugcugaacaa agaagagacu aagaaggaaa auuccuuuga gaugcagaaa      360

ggggaccaaa acccgcagau cgccgcacac gugauuagcg aggccuccag uaagaccacg      420

agcguccucc agugggcaga aaaaggcuau uacacuaugu ccaauaaccu ggugaccuug      480

gagaauggua agcagcugac ugugaaaagg caagggcucu auuacaucua ugcccagguc      540

accuucugca gcaaccggga agcgaguucc caggcccccu uuauugcaag ccugugucug      600

aaguccccag gccgcuucga gaggaucuug cuccgggccg ccaauaccca uaguagcgca      660

aaacccugcg gccagcaauc cauucaccuc gggggugugu uugaacugca gccaggcgcc      720

agcguauucg ugaacgucac ggaucccagu cagguguccc augggacugg cuucaccagc      780

uuuggucugc ugaaguugug aggacuaguu auaagacuga cuagcccgau gggccuccca      840

acgggcccuc cuccccuccu ugcaccgaga uuaauaaaaa aaaaaaaaaa aaaaaaaaaa      900

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaau gcaucccccc cccccccccc      960

cccccccccc cccccaaagg cucuuuucag agccaccaga auu                       1003


<210>  243
<211>  1084
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  PDCD1 mRNA product opt8

<400>  243
gggagaaagc uuaccaugca aaucccacaa gcccccuggc ccguagucug ggccguacua       60

caacuaggcu ggagacccgg cugguuucuc gacagccccg accgacccug gaaccccccc      120

accuucucac ccgcccuccu cgucgucacc gaaggcgaca acgccacauu cacaugcucc      180

uucuccaaca ccucugaauc auucguccua aacugguacc gaaugucacc cuccaaccaa      240

acugacaaac ucgccgccuu ucccgaagac cgcucccaac ccggccaaga cugccgauuc      300

cgagucacac aacuuccuaa cggcagagac uuccacaugu ccguaguccg agcccgccga      360

aacgacuccg gaaccuaccu cugcggagcc aucucccucg cccccaaagc ccaaaucaaa      420

gaaucccucc gagcagaacu ccgcgucacc gaacgccgcg ccgaaguccc caccgcacac      480

ccaucacccu ccccccgccc cgccggccaa uuccaaacac uuguaguagg cgucgucggc      540

ggccuccuug gaucacucgu ccuacuugua uggguccuag ccgucaucug cucucgcgcc      600

gcacgcggca ccaucggcgc acgacgaacc ggccaaccuc uaaaagaaga ccccuccgca      660

guccccgucu ucuccgucga cuacggcgaa cucgacuucc aauggcgcga aaaaaccccc      720

gaacccccag uccccugcgu acccgaacaa accgaauacg caacaaucgu auuccccuca      780

ggaaugggca ccucaucccc cgcccgacga ggaucagccg acggcccacg auccgcccaa      840

ccccuccgac cagaagacgg ccacugcuca uggccccuuu aaggacuagu uauaagacug      900

acuagcccga ugggccuccc aacgggcccu ccuccccucc uugcaccgag auuaauaaaa      960

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa     1020

ugcauccccc cccccccccc cccccccccc ccccccaaag gcucuuuuca gagccaccag     1080

aauu                                                                  1084


<210>  244
<211>  667
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  PDCD1(1-149) mRNA product opt8

<400>  244
gggagaaagc uuaccaugca aaucccacaa gcccccuggc ccguagucug ggccguacua       60

caacuaggcu ggagacccgg cugguuucuc gacagccccg accgacccug gaaccccccc      120

accuucucac ccgcccuccu cgucgucacc gaaggcgaca acgccacauu cacaugcucc      180

uucuccaaca ccucugaauc auucguccua aacugguacc gaaugucacc cuccaaccaa      240

acugacaaac ucgccgccuu ucccgaagac cgcucccaac ccggccaaga cugccgauuc      300

cgagucacac aacuuccuaa cggcagagac uuccacaugu ccguaguccg agcccgccga      360

aacgacuccg gaaccuaccu cugcggagcc aucucccucg cccccaaagc ccaaaucaaa      420

gaaucccucc gagcagaacu ccgcgucacc gaacgccgcg ccuaaggacu aguuauaaga      480

cugacuagcc cgaugggccu cccaacgggc ccuccucccc uccuugcacc gagauuaaua      540

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa      600

aaaugcaucc cccccccccc cccccccccc ccccccccca aaggcucuuu ucagagccac      660

cagaauu                                                                667


<210>  245
<211>  877
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  IL12A mRNA product opt8

<400>  245
gggagaaagc uuaccaugug ccccgccaga ucccuccuac ucgucgcaac acuuguccuc       60

cucgaccacc ucucccucgc ccgcaaucuc cccgucgcca cccccgaccc cggaauguuu      120

cccugccucc accacucaca aaaccuccua cgcgccgucu caaacaugcu ucaaaaagcc      180

cgacaaaccc ucgaauuuua ccccugcacc uccgaagaaa ucgaccacga agacauaacc      240

aaagacaaaa ccuccaccgu cgaagccugc cuaccauuag aacuaaccaa aaacgaaucc      300

ugccucaacu cacgcgaaac cuccuucauc acaaacggcu caugccucgc cucacgcaaa      360

accuccuuca ugauggcccu cugccuauca ucaaucuaug aagaccucaa aauguaccaa      420

guagaauuua aaaccaugaa cgccaaacuc cucauggacc ccaaacgcca aaucuuccuc      480

gaccaaaaca ugcucgcagu caucgacgaa cucaugcaag cccucaacuu caacucagaa      540

acagucccac aaaaauccuc ccucgaagaa cccgacuucu auaaaaccaa aaucaaacuc      600

ugcauccucc uccacgccuu ccgcauacgc gccguaacca ucgaccgcgu aaugucauac      660

cuaaaugccu cuuaaggacu aguuauaaga cugacuagcc cgaugggccu cccaacgggc      720

ccuccucccc uccuugcacc gagauuaaua aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa      780

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaugcaucc cccccccccc cccccccccc      840

ccccccccca aaggcucuuu ucagagccac cagaauu                               877


<210>  246
<211>  874
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  IL12A(1-219) mRNA product opt8

<400>  246
gggagaaagc uuaccaugug ccccgccaga ucccuccuac ucgucgcaac acuuguccuc       60

cucgaccacc ucucccucgc ccgcaaucuc cccgucgcca cccccgaccc cggaauguuu      120

cccugccucc accacucaca aaaccuccua cgcgccgucu caaacaugcu ucaaaaagcc      180

cgacaaaccc ucgaauuuua ccccugcacc uccgaagaaa ucgaccacga agacauaacc      240

aaagacaaaa ccuccaccgu cgaagccugc cuaccauuag aacuaaccaa aaacgaaucc      300

ugccucaacu cacgcgaaac cuccuucauc acaaacggcu caugccucgc cucacgcaaa      360

accuccuuca ugauggcccu cugccuauca ucaaucuaug aagaccucaa aauguaccaa      420

guagaauuua aaaccaugaa cgccaaacuc cucauggacc ccaaacgcca aaucuuccuc      480

gaccaaaaca ugcucgcagu caucgacgaa cucaugcaag cccucaacuu caacucagaa      540

acagucccac aaaaauccuc ccucgaagaa cccgacuucu auaaaaccaa aaucaaacuc      600

ugcauccucc uccacgccuu ccgcauacgc gccguaacca ucgaccgcgu aaugucauac      660

cuaaaugccu cuggacuagu uauaagacug acuagcccga ugggccuccc aacgggcccu      720

ccuccccucc uugcaccgag auuaauaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa      780

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa ugcauccccc cccccccccc cccccccccc      840

ccccccaaag gcucuuuuca gagccaccag aauu                                  874


<210>  247
<211>  811
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  IL12A(23-219) mRNA product opt8

<400>  247
gggagaaagc uuacccgcaa ucuccccguc gccacccccg accccggaau guuucccugc       60

cuccaccacu cacaaaaccu ccuacgcgcc gucucaaaca ugcuucaaaa agcccgacaa      120

acccucgaau uuuaccccug caccuccgaa gaaaucgacc acgaagacau aaccaaagac      180

aaaaccucca ccgucgaagc cugccuacca uuagaacuaa ccaaaaacga auccugccuc      240

aacucacgcg aaaccuccuu caucacaaac ggcucaugcc ucgccucacg caaaaccucc      300

uucaugaugg cccucugccu aucaucaauc uaugaagacc ucaaaaugua ccaaguagaa      360

uuuaaaacca ugaacgccaa acuccucaug gaccccaaac gccaaaucuu ccucgaccaa      420

aacaugcucg cagucaucga cgaacucaug caagcccuca acuucaacuc agaaacaguc      480

ccacaaaaau ccucccucga agaacccgac uucuauaaaa ccaaaaucaa acucugcauc      540

cuccuccacg ccuuccgcau acgcgccgua accaucgacc gcguaauguc auaccuaaau      600

gccucuuaag gacuaguuau aagacugacu agcccgaugg gccucccaac gggcccuccu      660

ccccuccuug caccgagauu aauaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa      720

aaaaaaaaaa aaaaaaaaaa aaaaaaaugc aucccccccc cccccccccc cccccccccc      780

cccaaaggcu cuuuucagag ccaccagaau u                                     811


<210>  248
<211>  1204
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  IL12B mRNA product opt8

<400>  248
gggagaaagc uuaccaugug ccaccaacaa cucgucauaa gcugguucag ccuaguauuc       60

cucgccucac cccucgucgc caucugggaa cucaagaaag acguauacgu cgucgaacua      120

gacugguacc ccgacgcacc cggagaaaug guaguacuca caugcgacac ccccgaagaa      180

gacggcauca cauggaccuu agaccaauca ucagaagucc ucggauccgg aaaaacccuc      240

acaauccaag ucaaagaguu cggcgacgcc ggccaauaca caugccacaa aggcggagaa      300

guccucucac acucacuccu ucuacuacac aagaaagaag acggcaucug guccaccgac      360

auacucaaag accaaaaaga acccaaaaac aaaaccuucc uccgcugcga agccaaaaac      420

uacuccggcc gauucacaug cugguggcuc accaccaucu ccaccgaccu gaccuucucc      480

gucaaaucca gcaggggcuc cucagaccca caaggcguaa ccugcggcgc agccacccua      540

ucggccgaac gaguccgcgg agacaacaaa gaauacgaau acagcgucga augccaagaa      600

gacucagcau gcccagcagc cgaagaauca cuccccaucg aagucauggu cgacgccguc      660

cacaaacuaa aauacgaaaa cuacacaagc ucauucuuca uccgcgacau aaucaaaccc      720

gacccaccga aaaaccucca acucaaaccc cuuaaaaaca gccgccaagu cgaagucucc      780

ugggaauacc ccgacaccug guccacaccc cacuccuacu ucucacucac cuucugcguc      840

caaguccaag gcaaauccaa acgcgaaaag aaagaccgcg uauucaccga caaaaccucc      900

gccacaguca ucugccgcaa aaacgccuca aucuccgucc gcgcccaaga ccgauacuac      960

agcuccuccu ggucagaaug ggccuccguc ccaugcuccu aaggacuagu uauaagacug     1020

acuagcccga ugggccuccc aacgggcccu ccuccccucc uugcaccgag auuaauaaaa     1080

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa     1140

ugcauccccc cccccccccc cccccccccc ccccccaaag gcucuuuuca gagccaccag     1200

aauu                                                                  1204


<210>  249
<211>  1201
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  IL12B(1-328) mRNA product opt8

<400>  249
gggagaaagc uuaccaugug ccaccaacaa cucgucauaa gcugguucag ccuaguauuc       60

cucgccucac cccucgucgc caucugggaa cucaagaaag acguauacgu cgucgaacua      120

gacugguacc ccgacgcacc cggagaaaug guaguacuca caugcgacac ccccgaagaa      180

gacggcauca cauggaccuu agaccaauca ucagaagucc ucggauccgg aaaaacccuc      240

acaauccaag ucaaagaguu cggcgacgcc ggccaauaca caugccacaa aggcggagaa      300

guccucucac acucacuccu ucuacuacac aagaaagaag acggcaucug guccaccgac      360

auacucaaag accaaaaaga acccaaaaac aaaaccuucc uccgcugcga agccaaaaac      420

uacuccggcc gauucacaug cugguggcuc accaccaucu ccaccgaccu gaccuucucc      480

gucaaaucca gcaggggcuc cucagaccca caaggcguaa ccugcggcgc agccacccua      540

ucggccgaac gaguccgcgg agacaacaaa gaauacgaau acagcgucga augccaagaa      600

gacucagcau gcccagcagc cgaagaauca cuccccaucg aagucauggu cgacgccguc      660

cacaaacuaa aauacgaaaa cuacacaagc ucauucuuca uccgcgacau aaucaaaccc      720

gacccaccga aaaaccucca acucaaaccc cuuaaaaaca gccgccaagu cgaagucucc      780

ugggaauacc ccgacaccug guccacaccc cacuccuacu ucucacucac cuucugcguc      840

caaguccaag gcaaauccaa acgcgaaaag aaagaccgcg uauucaccga caaaaccucc      900

gccacaguca ucugccgcaa aaacgccuca aucuccgucc gcgcccaaga ccgauacuac      960

agcuccuccu ggucagaaug ggccuccguc ccaugcuccg gacuaguuau aagacugacu     1020

agcccgaugg gccucccaac gggcccuccu ccccuccuug caccgagauu aauaaaaaaa     1080

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaugc     1140

aucccccccc cccccccccc cccccccccc cccaaaggcu cuuuucagag ccaccagaau     1200

u                                                                     1201


<210>  250
<211>  1138
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  IL12B(23-328) mRNA product opt8

<400>  250
gggagaaagc uuaccaucug ggaacucaag aaagacguau acgucgucga acuagacugg       60

uaccccgacg cacccggaga aaugguagua cucacaugcg acacccccga agaagacggc      120

aucacaugga ccuuagacca aucaucagaa guccucggau ccggaaaaac ccucacaauc      180

caagucaaag aguucggcga cgccggccaa uacacaugcc acaaaggcgg agaaguccuc      240

ucacacucac uccuucuacu acacaagaaa gaagacggca ucugguccac cgacauacuc      300

aaagaccaaa aagaacccaa aaacaaaacc uuccuccgcu gcgaagccaa aaacuacucc      360

ggccgauuca caugcuggug gcucaccacc aucuccaccg accugaccuu cuccgucaaa      420

uccagcaggg gcuccucaga cccacaaggc guaaccugcg gcgcagccac ccuaucggcc      480

gaacgagucc gcggagacaa caaagaauac gaauacagcg ucgaaugcca agaagacuca      540

gcaugcccag cagccgaaga aucacucccc aucgaaguca uggucgacgc cguccacaaa      600

cuaaaauacg aaaacuacac aagcucauuc uucauccgcg acauaaucaa acccgaccca      660

ccgaaaaacc uccaacucaa accccuuaaa aacagccgcc aagucgaagu cuccugggaa      720

uaccccgaca ccugguccac accccacucc uacuucucac ucaccuucug cguccaaguc      780

caaggcaaau ccaaacgcga aaagaaagac cgcguauuca ccgacaaaac cuccgccaca      840

gucaucugcc gcaaaaacgc cucaaucucc guccgcgccc aagaccgaua cuacagcucc      900

uccuggucag aaugggccuc cgucccaugc uccuaaggac uaguuauaag acugacuagc      960

ccgaugggcc ucccaacggg cccuccuccc cuccuugcac cgagauuaau aaaaaaaaaa     1020

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaugcauc     1080

cccccccccc cccccccccc cccccccccc aaaggcucuu uucagagcca ccagaauu       1138


<210>  251
<211>  271
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Linker-sFvCC49-218 mRNA product opt8

<400>  251
gggagaaagc uuaccgggag cacgagcggg agcgggaagc cgggaagugg agagggaagu       60

acaaagggag gacuaguuau aagacugacu agcccgaugg gccucccaac gggcccuccu      120

ccccuccuug caccgagauu aauaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa      180

aaaaaaaaaa aaaaaaaaaa aaaaaaaugc aucccccccc cccccccccc cccccccccc      240

cccaaaggcu cuuuucagag ccaccagaau u                                     271


<210>  252
<211>  1849
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  IL12 mRNA product opt8

<400>  252
gggagaaagc uuaccaugug ccaccaacaa cucgucauaa gcugguucag ccuaguauuc       60

cucgccucac cccucgucgc caucugggaa cucaagaaag acguauacgu cgucgaacua      120

gacugguacc ccgacgcacc cggagaaaug guaguacuca caugcgacac ccccgaagaa      180

gacggcauca cauggaccuu agaccaauca ucagaagucc ucggauccgg aaaaacccuc      240

acaauccaag ucaaagaguu cggcgacgcc ggccaauaca caugccacaa aggcggagaa      300

guccucucac acucacuccu ucuacuacac aagaaagaag acggcaucug guccaccgac      360

auacucaaag accaaaaaga acccaaaaac aaaaccuucc uccgcugcga agccaaaaac      420

uacuccggcc gauucacaug cugguggcuc accaccaucu ccaccgaccu gaccuucucc      480

gucaaaucca gcaggggcuc cucagaccca caaggcguaa ccugcggcgc agccacccua      540

ucggccgaac gaguccgcgg agacaacaaa gaauacgaau acagcgucga augccaagaa      600

gacucagcau gcccagcagc cgaagaauca cuccccaucg aagucauggu cgacgccguc      660

cacaaacuaa aauacgaaaa cuacacaagc ucauucuuca uccgcgacau aaucaaaccc      720

gacccaccga aaaaccucca acucaaaccc cuuaaaaaca gccgccaagu cgaagucucc      780

ugggaauacc ccgacaccug guccacaccc cacuccuacu ucucacucac cuucugcguc      840

caaguccaag gcaaauccaa acgcgaaaag aaagaccgcg uauucaccga caaaaccucc      900

gccacaguca ucugccgcaa aaacgccuca aucuccgucc gcgcccaaga ccgauacuac      960

agcuccuccu ggucagaaug ggccuccguc ccaugcuccg ggagcacgag cgggagcggg     1020

aagccgggaa guggagaggg aaguacaaag ggacgcaauc uccccgucgc cacccccgac     1080

cccggaaugu uucccugccu ccaccacuca caaaaccucc uacgcgccgu cucaaacaug     1140

cuucaaaaag cccgacaaac ccucgaauuu uaccccugca ccuccgaaga aaucgaccac     1200

gaagacauaa ccaaagacaa aaccuccacc gucgaagccu gccuaccauu agaacuaacc     1260

aaaaacgaau ccugccucaa cucacgcgaa accuccuuca ucacaaacgg cucaugccuc     1320

gccucacgca aaaccuccuu caugauggcc cucugccuau caucaaucua ugaagaccuc     1380

aaaauguacc aaguagaauu uaaaaccaug aacgccaaac uccucaugga ccccaaacgc     1440

caaaucuucc ucgaccaaaa caugcucgca gucaucgacg aacucaugca agcccucaac     1500

uucaacucag aaacaguccc acaaaaaucc ucccucgaag aacccgacuu cuauaaaacc     1560

aaaaucaaac ucugcauccu ccuccacgcc uuccgcauac gcgccguaac caucgaccgc     1620

guaaugucau accuaaaugc cucuuaagga cuaguuauaa gacugacuag cccgaugggc     1680

cucccaacgg gcccuccucc ccuccuugca ccgagauuaa uaaaaaaaaa aaaaaaaaaa     1740

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaugcau cccccccccc     1800

cccccccccc cccccccccc caaaggcucu uuucagagcc accagaauu                 1849


<210>  253
<211>  1003
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  CD40LG mRNA product opt8

<400>  253
gggagaaagc uuaccaugau agaaaccuac aaccaaaccu cuccccgauc cgcagccacc       60

ggccucccca ucuccaugaa aaucuucaug uaccuccuaa ccgucuuccu aaucacucaa      120

augaucggcu ccgcucucuu cgcagucuac cuccaccgcc gccuagacaa aaucgaagac      180

gaacgcaacc uacacgaaga cuucgucuuc augaaaacca uucaacgcug caacacaggc      240

gaacgauccc uaucccuacu caacugcgaa gaaaucaaau cccaauucga aggcuuugua      300

aaagacauca ugcucaacaa agaagaaacc aaaaaagaaa acuccuucga aaugcaaaaa      360

ggcgaccaaa acccccaaau agccgcccau gucauaucag aagccuccuc caaaaccacc      420

uccguccucc aaugggccga aaaaggcuac uacaccaugu ccaacaaccu aguaacccuu      480

gaaaacggca aacaacucac cguaaaacgc caaggccucu acuacaucua cgcccaaguc      540

accuucugcu ccaacagaga agcauccucc caagcacccu ucaucgccuc ccuaugccuc      600

aaaucccccg gccgcuucga acgaauccuc cuccgcgccg ccaacacuca cuccucagcc      660

aaacccugcg gccaacaaag uauacaccuu ggcggagucu ucgaacucca acccggcgcc      720

uccgucuucg uaaacgucac cgaccccuca caagucuccc acggaaccgg auucaccucc      780

uucggccuac uaaaacuaua gggacuaguu auaagacuga cuagcccgau gggccuccca      840

acgggcccuc cuccccuccu ugcaccgaga uuaauaaaaa aaaaaaaaaa aaaaaaaaaa      900

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaau gcaucccccc cccccccccc      960

cccccccccc cccccaaagg cucuuuucag agccaccaga auu                       1003


<210>  254
<211>  1084
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  PDCD1 mRNA product opt9

<400>  254
gggagaaagc uuaccaugca aaucccccaa gccccauggc ccgucgucug ggccguccuc       60

caacucggcu ggcgccccgg augguuccua gacucuccag accgccccug gaauccaccc      120

accuucuccc ccgcccuccu agucgucacc gaaggcgaca acgccaccuu caccuguuca      180

uucuccaaca ccucagaauc cuucguacuc aacugguacc gcaugucccc aagcaaccaa      240

acagacaaac ucgccgccuu ccccgaagac cgcucccaac ccggucaaga cugccgauuc      300

cgcgucaccc aacuccccaa cggacgcgac uuccacaugu ccgucguucg agcacgacgc      360

aacgacucag gcacauaccu augcggagcc aucucccuag cccccaaagc ccaaaucaaa      420

gaaucacuac gcgccgaacu ccgcgucacc gaacgccgcg ccgaaguacc cacagcccac      480

ccauccccau caccacgccc agcaggucaa uuccaaaccu uagucgucgg agucgucggc      540

ggccuccuag gcucacucgu ccuccuaguc uggguccucg ccgucauaug cagccgcgcc      600

gcacgcggca ccaucggcgc cagacgcacc ggacaacccc ucaaagaaga ccccucagcc      660

guccccgucu uuuccgucga cuacggcgaa cuagacuucc aauggcgcga aaaaaccccc      720

gaaccccccg ucccaugcgu acccgaacaa accgaauacg ccacaauagu cuucccaucc      780

ggcaugggaa ccucaucacc cgccagacga ggcucagcag auggcccccg cuccgcacaa      840

ccacuccgac cagaagacgg ccacugcagc uggccccugu aaggacuagu uauaagacug      900

acuagcccga ugggccuccc aacgggcccu ccuccccucc uugcaccgag auuaauaaaa      960

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa     1020

ugcauccccc cccccccccc cccccccccc ccccccaaag gcucuuuuca gagccaccag     1080

aauu                                                                  1084


<210>  255
<211>  667
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  PDCD1(1-149) mRNA product opt9

<400>  255
gggagaaagc uuaccaugca aaucccccaa gccccauggc ccgucgucug ggccguccuc       60

caacucggcu ggcgccccgg augguuccua gacucuccag accgccccug gaauccaccc      120

accuucuccc ccgcccuccu agucgucacc gaaggcgaca acgccaccuu caccuguuca      180

uucuccaaca ccucagaauc cuucguacuc aacugguacc gcaugucccc aagcaaccaa      240

acagacaaac ucgccgccuu ccccgaagac cgcucccaac ccggucaaga cugccgauuc      300

cgcgucaccc aacuccccaa cggacgcgac uuccacaugu ccgucguucg agcacgacgc      360

aacgacucag gcacauaccu augcggagcc aucucccuag cccccaaagc ccaaaucaaa      420

gaaucacuac gcgccgaacu ccgcgucacc gaacgccgcg ccuaaggacu aguuauaaga      480

cugacuagcc cgaugggccu cccaacgggc ccuccucccc uccuugcacc gagauuaaua      540

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa      600

aaaugcaucc cccccccccc cccccccccc ccccccccca aaggcucuuu ucagagccac      660

cagaauu                                                                667


<210>  256
<211>  877
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  IL12A mRNA product opt9

<400>  256
gggagaaagc uuaccaugug ccccgccaga ucccuccucc ucgucgcaac ccucguccuc       60

cucgaccacc ucucccuagc acguaaccuc ccagucgcca ccccagaccc cggaauguuc      120

cccugccucc aucacuccca aaaucuccuc cgugccgucu ccaacaugcu ccaaaaagcc      180

cgccaaaccc ucgaauuuua uccaugcacc uccgaagaaa uagaccauga agacaucacc      240

aaagacaaaa cauccaccgu cgaagccugc cucccccucg aacucacaaa aaacgaauca      300

ugccucaacu cccgcgaaac cuccuucaua accaacggcu caugccucgc cucucgcaaa      360

accucauuca ugauggcccu cugccuaucc ucuaucuacg aagaccucaa aauguaccaa      420

gucgaauuua aaaccaugaa cgccaaacuc cucauggacc ccaaacgcca aaucuuccuc      480

gaccaaaaca ugcucgcagu caucgacgaa cucaugcaag cacucaacuu caacucagaa      540

accguccccc aaaaauccuc ccucgaagaa cccgacuucu acaaaacaaa aauaaaacuc      600

ugcauccucc uccacgccuu ccgcauccga gcagucacca ucgaucgcgu cauguccuac      660

cuaaacgccu ccuaaggacu aguuauaaga cugacuagcc cgaugggccu cccaacgggc      720

ccuccucccc uccuugcacc gagauuaaua aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa      780

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaugcaucc cccccccccc cccccccccc      840

ccccccccca aaggcucuuu ucagagccac cagaauu                               877


<210>  257
<211>  874
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  IL12A(1-219) mRNA product opt9

<400>  257
gggagaaagc uuaccaugug ccccgccaga ucccuccucc ucgucgcaac ccucguccuc       60

cucgaccacc ucucccuagc acguaaccuc ccagucgcca ccccagaccc cggaauguuc      120

cccugccucc aucacuccca aaaucuccuc cgugccgucu ccaacaugcu ccaaaaagcc      180

cgccaaaccc ucgaauuuua uccaugcacc uccgaagaaa uagaccauga agacaucacc      240

aaagacaaaa cauccaccgu cgaagccugc cucccccucg aacucacaaa aaacgaauca      300

ugccucaacu cccgcgaaac cuccuucaua accaacggcu caugccucgc cucucgcaaa      360

accucauuca ugauggcccu cugccuaucc ucuaucuacg aagaccucaa aauguaccaa      420

gucgaauuua aaaccaugaa cgccaaacuc cucauggacc ccaaacgcca aaucuuccuc      480

gaccaaaaca ugcucgcagu caucgacgaa cucaugcaag cacucaacuu caacucagaa      540

accguccccc aaaaauccuc ccucgaagaa cccgacuucu acaaaacaaa aauaaaacuc      600

ugcauccucc uccacgccuu ccgcauccga gcagucacca ucgaucgcgu cauguccuac      660

cuaaacgccu ccggacuagu uauaagacug acuagcccga ugggccuccc aacgggcccu      720

ccuccccucc uugcaccgag auuaauaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa      780

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa ugcauccccc cccccccccc cccccccccc      840

ccccccaaag gcucuuuuca gagccaccag aauu                                  874


<210>  258
<211>  811
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  IL12A(23-219) mRNA product opt9

<400>  258
gggagaaagc uuacccguaa ccucccaguc gccaccccag accccggaau guuccccugc       60

cuccaucacu cccaaaaucu ccuccgugcc gucuccaaca ugcuccaaaa agcccgccaa      120

acccucgaau uuuauccaug caccuccgaa gaaauagacc augaagacau caccaaagac      180

aaaacaucca ccgucgaagc cugccucccc cucgaacuca caaaaaacga aucaugccuc      240

aacucccgcg aaaccuccuu cauaaccaac ggcucaugcc ucgccucucg caaaaccuca      300

uucaugaugg cccucugccu auccucuauc uacgaagacc ucaaaaugua ccaagucgaa      360

uuuaaaacca ugaacgccaa acuccucaug gaccccaaac gccaaaucuu ccucgaccaa      420

aacaugcucg cagucaucga cgaacucaug caagcacuca acuucaacuc agaaaccguc      480

ccccaaaaau ccucccucga agaacccgac uucuacaaaa caaaaauaaa acucugcauc      540

cuccuccacg ccuuccgcau ccgagcaguc accaucgauc gcgucauguc cuaccuaaac      600

gccuccuaag gacuaguuau aagacugacu agcccgaugg gccucccaac gggcccuccu      660

ccccuccuug caccgagauu aauaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa      720

aaaaaaaaaa aaaaaaaaaa aaaaaaaugc aucccccccc cccccccccc cccccccccc      780

cccaaaggcu cuuuucagag ccaccagaau u                                     811


<210>  259
<211>  1204
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  IL12B mRNA product opt9

<400>  259
gggagaaagc uuaccaugug ucaccaacaa cuuguaauca gcugguucuc ccucgucuuc       60

cucgccucac cccucgucgc caucugggaa cucaaaaaag acgucuacgu agucgaacuc      120

gacugguacc ccgacgcccc aggagaaaug gucguacuca ccugugacac ccccgaagaa      180

gacggcauca ccuggacccu cgaccaaucc uccgaagucc ucgguucagg aaaaacccuc      240

accauccaag uaaaagaauu uggcgacgcc gggcaauaua ccugccacaa aggcggcgag      300

guccuauccc acucacuccu ccuccuccac aagaaagaag acggaaucug guccaccgac      360

auccuuaaag accaaaaaga accaaaaaac aaaacauucc uccgcugcga agccaaaaac      420

uacagcggcc gcuucaccug uugguggcua accacaauau caaccgacuu aaccuucagc      480

gucaaauccu ccagaggauc cagcgaccca caaggaguua ccugcggagc cgcaacacuc      540

agcgccgaac gaguccgcgg agacaacaaa gaauacgaau acuccgucga augccaagaa      600

gacucagcau gccccgccgc agaagaaucc cuacccaucg aaguaauggu agacgccguc      660

cacaaacuca aauacgaaaa cuacaccagc uccuucuuca uccgagacau caucaaaccc      720

gaccccccaa aaaaccucca acuaaaaccc cucaaaaaca gccgccaagu agaaguaucc      780

ugggaauacc ccgacaccug guccacaccc cacuccuacu ucucgcucac guucugcguc      840

caaguccaag gcaaauccaa acgagaaaaa aaagaccgcg ucuucaccga caaaacuucc      900

gccaccguca ucugccgcaa aaacgccagc aucagcgucc gcgcacaaga ccgcuacuac      960

ucaagcuccu gguccgaaug ggccuccguc ccaugcucau aaggacuagu uauaagacug     1020

acuagcccga ugggccuccc aacgggcccu ccuccccucc uugcaccgag auuaauaaaa     1080

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa     1140

ugcauccccc cccccccccc cccccccccc ccccccaaag gcucuuuuca gagccaccag     1200

aauu                                                                  1204


<210>  260
<211>  1201
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  IL12B(1-328) mRNA product opt9

<400>  260
gggagaaagc uuaccaugug ucaccaacaa cuuguaauca gcugguucuc ccucgucuuc       60

cucgccucac cccucgucgc caucugggaa cucaaaaaag acgucuacgu agucgaacuc      120

gacugguacc ccgacgcccc aggagaaaug gucguacuca ccugugacac ccccgaagaa      180

gacggcauca ccuggacccu cgaccaaucc uccgaagucc ucgguucagg aaaaacccuc      240

accauccaag uaaaagaauu uggcgacgcc gggcaauaua ccugccacaa aggcggcgag      300

guccuauccc acucacuccu ccuccuccac aagaaagaag acggaaucug guccaccgac      360

auccuuaaag accaaaaaga accaaaaaac aaaacauucc uccgcugcga agccaaaaac      420

uacagcggcc gcuucaccug uugguggcua accacaauau caaccgacuu aaccuucagc      480

gucaaauccu ccagaggauc cagcgaccca caaggaguua ccugcggagc cgcaacacuc      540

agcgccgaac gaguccgcgg agacaacaaa gaauacgaau acuccgucga augccaagaa      600

gacucagcau gccccgccgc agaagaaucc cuacccaucg aaguaauggu agacgccguc      660

cacaaacuca aauacgaaaa cuacaccagc uccuucuuca uccgagacau caucaaaccc      720

gaccccccaa aaaaccucca acuaaaaccc cucaaaaaca gccgccaagu agaaguaucc      780

ugggaauacc ccgacaccug guccacaccc cacuccuacu ucucgcucac guucugcguc      840

caaguccaag gcaaauccaa acgagaaaaa aaagaccgcg ucuucaccga caaaacuucc      900

gccaccguca ucugccgcaa aaacgccagc aucagcgucc gcgcacaaga ccgcuacuac      960

ucaagcuccu gguccgaaug ggccuccguc ccaugcucag gacuaguuau aagacugacu     1020

agcccgaugg gccucccaac gggcccuccu ccccuccuug caccgagauu aauaaaaaaa     1080

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaugc     1140

aucccccccc cccccccccc cccccccccc cccaaaggcu cuuuucagag ccaccagaau     1200

u                                                                     1201


<210>  261
<211>  1138
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  IL12B(23-328) mRNA product opt9

<400>  261
gggagaaagc uuaccaucug ggaacucaaa aaagacgucu acguagucga acucgacugg       60

uaccccgacg ccccaggaga aauggucgua cucaccugug acacccccga agaagacggc      120

aucaccugga cccucgacca auccuccgaa guccucgguu caggaaaaac ccucaccauc      180

caaguaaaag aauuuggcga cgccgggcaa uauaccugcc acaaaggcgg cgagguccua      240

ucccacucac uccuccuccu ccacaagaaa gaagacggaa ucugguccac cgacauccuu      300

aaagaccaaa aagaaccaaa aaacaaaaca uuccuccgcu gcgaagccaa aaacuacagc      360

ggccgcuuca ccuguuggug gcuaaccaca auaucaaccg acuuaaccuu cagcgucaaa      420

uccuccagag gauccagcga cccacaagga guuaccugcg gagccgcaac acucagcgcc      480

gaacgagucc gcggagacaa caaagaauac gaauacuccg ucgaaugcca agaagacuca      540

gcaugccccg ccgcagaaga aucccuaccc aucgaaguaa ugguagacgc cguccacaaa      600

cucaaauacg aaaacuacac cagcuccuuc uucauccgag acaucaucaa acccgacccc      660

ccaaaaaacc uccaacuaaa accccucaaa aacagccgcc aaguagaagu auccugggaa      720

uaccccgaca ccugguccac accccacucc uacuucucgc ucacguucug cguccaaguc      780

caaggcaaau ccaaacgaga aaaaaaagac cgcgucuuca ccgacaaaac uuccgccacc      840

gucaucugcc gcaaaaacgc cagcaucagc guccgcgcac aagaccgcua cuacucaagc      900

uccugguccg aaugggccuc cgucccaugc ucauaaggac uaguuauaag acugacuagc      960

ccgaugggcc ucccaacggg cccuccuccc cuccuugcac cgagauuaau aaaaaaaaaa     1020

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaugcauc     1080

cccccccccc cccccccccc cccccccccc aaaggcucuu uucagagcca ccagaauu       1138


<210>  262
<211>  271
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Linker-sFvCC49-218 mRNA product opt9

<400>  262
gggagaaagc uuaccgggag uacgaguggg agugggaagc cggggagugg ggaggggagu       60

acgaaggggg gacuaguuau aagacugacu agcccgaugg gccucccaac gggcccuccu      120

ccccuccuug caccgagauu aauaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa      180

aaaaaaaaaa aaaaaaaaaa aaaaaaaugc aucccccccc cccccccccc cccccccccc      240

cccaaaggcu cuuuucagag ccaccagaau u                                     271


<210>  263
<211>  1849
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  IL12 mRNA product opt9

<400>  263
gggagaaagc uuaccaugug ucaccaacaa cuuguaauca gcugguucuc ccucgucuuc       60

cucgccucac cccucgucgc caucugggaa cucaaaaaag acgucuacgu agucgaacuc      120

gacugguacc ccgacgcccc aggagaaaug gucguacuca ccugugacac ccccgaagaa      180

gacggcauca ccuggacccu cgaccaaucc uccgaagucc ucgguucagg aaaaacccuc      240

accauccaag uaaaagaauu uggcgacgcc gggcaauaua ccugccacaa aggcggcgag      300

guccuauccc acucacuccu ccuccuccac aagaaagaag acggaaucug guccaccgac      360

auccuuaaag accaaaaaga accaaaaaac aaaacauucc uccgcugcga agccaaaaac      420

uacagcggcc gcuucaccug uugguggcua accacaauau caaccgacuu aaccuucagc      480

gucaaauccu ccagaggauc cagcgaccca caaggaguua ccugcggagc cgcaacacuc      540

agcgccgaac gaguccgcgg agacaacaaa gaauacgaau acuccgucga augccaagaa      600

gacucagcau gccccgccgc agaagaaucc cuacccaucg aaguaauggu agacgccguc      660

cacaaacuca aauacgaaaa cuacaccagc uccuucuuca uccgagacau caucaaaccc      720

gaccccccaa aaaaccucca acuaaaaccc cucaaaaaca gccgccaagu agaaguaucc      780

ugggaauacc ccgacaccug guccacaccc cacuccuacu ucucgcucac guucugcguc      840

caaguccaag gcaaauccaa acgagaaaaa aaagaccgcg ucuucaccga caaaacuucc      900

gccaccguca ucugccgcaa aaacgccagc aucagcgucc gcgcacaaga ccgcuacuac      960

ucaagcuccu gguccgaaug ggccuccguc ccaugcucag ggaguacgag ugggaguggg     1020

aagccgggga guggggaggg gaguacgaag gggcguaacc ucccagucgc caccccagac     1080

cccggaaugu uccccugccu ccaucacucc caaaaucucc uccgugccgu cuccaacaug     1140

cuccaaaaag cccgccaaac ccucgaauuu uauccaugca ccuccgaaga aauagaccau     1200

gaagacauca ccaaagacaa aacauccacc gucgaagccu gccucccccu cgaacucaca     1260

aaaaacgaau caugccucaa cucccgcgaa accuccuuca uaaccaacgg cucaugccuc     1320

gccucucgca aaaccucauu caugauggcc cucugccuau ccucuaucua cgaagaccuc     1380

aaaauguacc aagucgaauu uaaaaccaug aacgccaaac uccucaugga ccccaaacgc     1440

caaaucuucc ucgaccaaaa caugcucgca gucaucgacg aacucaugca agcacucaac     1500

uucaacucag aaaccguccc ccaaaaaucc ucccucgaag aacccgacuu cuacaaaaca     1560

aaaauaaaac ucugcauccu ccuccacgcc uuccgcaucc gagcagucac caucgaucgc     1620

gucauguccu accuaaacgc cuccuaagga cuaguuauaa gacugacuag cccgaugggc     1680

cucccaacgg gcccuccucc ccuccuugca ccgagauuaa uaaaaaaaaa aaaaaaaaaa     1740

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaugcau cccccccccc     1800

cccccccccc cccccccccc caaaggcucu uuucagagcc accagaauu                 1849


<210>  264
<211>  1003
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  CD40LG mRNA product opt9

<400>  264
gggagaaagc uuaccaugau cgaaacauac aaccaaacau ccccccgcuc cgccgccaca       60

ggccucccca ucuccaugaa aaucuucaug uaccuccuca caguauuccu caucacccaa      120

augaucggcu ccgcacucuu ugcagucuau cuccaccguc gccucgacaa aaucgaagac      180

gaacgcaacc uccacgaaga cuucgucuuc augaaaacca uacaacgcug caacaccggc      240

gaacgcucac ucucccuacu aaacugcgaa gaaaucaaau cccaauucga aggcuucguc      300

aaagacauca ugcuaaacaa agaagaaaca aaaaaagaaa acuccuucga aaugcaaaaa      360

ggcgaccaaa acccccaaau agccgcccac gucaucuccg aagccuccuc caaaaccacc      420

uccguccucc aaugggccga aaaaggcuac uacacaaugu ccaacaaccu cgucacccuc      480

gaaaacggca aacaacucac cgucaaacgc caaggccucu acuacaucua cgcccaagua      540

accuucugcu ccaaccgcga agccucaucu caagcucccu ucaucgccuc acucugccuc      600

aaaucacccg gccgcuucga aagaauccuc cuccgcgccg caaacaccca cucauccgcc      660

aaacccugcg gccaacaauc cauacaccuc ggcggcguuu ucgagcucca accuggcgcc      720

uccgucuucg uaaacgucac cgaccccuca caagucuccc acgguaccgg cuucaccucc      780

uucggacucc uaaaacucua aggacuaguu auaagacuga cuagcccgau gggccuccca      840

acgggcccuc cuccccuccu ugcaccgaga uuaauaaaaa aaaaaaaaaa aaaaaaaaaa      900

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaau gcaucccccc cccccccccc      960

cccccccccc cccccaaagg cucuuuucag agccaccaga auu                       1003


<210>  265
<211>  1084
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  PDCD1 mRNA product opt10

<400>  265
gggagaaagc uuaccaugca aaucccccaa gcccccuggc cggucgucug ggccguccuc       60

caacucggcu ggcgccccgg augguuccuc gacucccccg accgcccgug gaaccccccc      120

accuucuccc ccgcccuccu agucgucacc gaaggcgaca acgccaccuu caccuguucc      180

uucuccaaca ccucagaauc cuucguccuc aacugguacc gcaugucccc cuccaaccaa      240

accgacaaac ucgccgccuu ccccgaagac cgaucccaac ccggccaaga cugccgcuuc      300

cgcgucacac aacuucccaa cggacgcgac uuucacaugu ccgucguccg cgcccgccgc      360

aacgacuccg gcaccuaccu cugcggcgcc aucucccucg cccccaaagc ccaaaucaaa      420

gaaucccuca gagccgaacu ccgcgucacc gaacggcgcg ccgaaguccc cacugcccac      480

cccucccccu ccccccgccc cgccggccaa uuccaaaccc ucgucgucgg cguugucggc      540

ggccuccucg gcucacucgu ccuccucguc uggguacucg ccgucaucug cucccgcgcc      600

gcgcgcggca ccaucggcgc gcgccgcacc ggacaacccc uaaaagaaga ccccuccgcc      660

guccccgucu ucuccgucga cuacggcgaa cucgacuucc aauggcgcga aaaaaccccg      720

gaaccccccg ucccgugcgu ccccgaacaa acagaauacg cgaccaucgu cuucccgucc      780

ggcaugggca cauccucacc cgcccgccga ggcuccgccg acggcccccg auccgcccaa      840

ccccuacgcc ccgaagacgg ccacugcucc uggccccucu aaggacuagu uauaagacug      900

acuagcccga ugggccuccc aacgggcccu ccuccccucc uugcaccgag auuaauaaaa      960

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa     1020

ugcauccccc cccccccccc cccccccccc ccccccaaag gcucuuuuca gagccaccag     1080

aauu                                                                  1084


<210>  266
<211>  667
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  PDCD1(1-149) mRNA product opt10

<400>  266
gggagaaagc uuaccaugca aaucccccaa gcccccuggc cggucgucug ggccguccuc       60

caacucggcu ggcgccccgg augguuccuc gacucccccg accgcccgug gaaccccccc      120

accuucuccc ccgcccuccu agucgucacc gaaggcgaca acgccaccuu caccuguucc      180

uucuccaaca ccucagaauc cuucguccuc aacugguacc gcaugucccc cuccaaccaa      240

accgacaaac ucgccgccuu ccccgaagac cgaucccaac ccggccaaga cugccgcuuc      300

cgcgucacac aacuucccaa cggacgcgac uuucacaugu ccgucguccg cgcccgccgc      360

aacgacuccg gcaccuaccu cugcggcgcc aucucccucg cccccaaagc ccaaaucaaa      420

gaaucccuca gagccgaacu ccgcgucacc gaacggcgcg ccuaaggacu aguuauaaga      480

cugacuagcc cgaugggccu cccaacgggc ccuccucccc uccuugcacc gagauuaaua      540

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa      600

aaaugcaucc cccccccccc cccccccccc ccccccccca aaggcucuuu ucagagccac      660

cagaauu                                                                667


<210>  267
<211>  877
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  IL12A mRNA product opt10

<400>  267
gggagaaagc uuaccaugug ccccgcccgu ucacuccucc ucgucgccac ccucguccuc       60

cuagaccacc ucucccuggc ccgcaaccuc ccagucgcca cccccgaccc cggcauguuc      120

cccugccucc accacuccca aaaccuccuc cgcgccgucu ccaacaugcu ccaaaaagcc      180

cgccaaaccc ucgaauuuua ccccugcacc uccgaagaga ucgaccacga agacaucacc      240

aaagacaaaa ccuccacagu cgaagccugc cucccccucg aacucaccaa aaacgaaucc      300

ugccuuaacu cccgcgaaac cuccuucauc accaacggcu ccugccucgc cucccgcaaa      360

accuccuuca ugauggcccu cugccucucc uccaucuacg aagaccucaa aauguaccaa      420

gucgaauuua aaaccaugaa cgccaaacuc cucauggacc ccaaacgcca aaucuuccuc      480

gaccaaaaca ugcucgccgu caucgacgaa cucaugcaag cccucaacuu caacuccgaa      540

accguccccc aaaaauccuc ccucgaagaa cccgacuucu acaaaaccaa aaucaaacuu      600

ugcauccucc uccacgcauu ccgcauccgc gccgucacca ucgaccgugu caugagcuac      660

cuaaacgccu ccugaggacu aguuauaaga cugacuagcc cgaugggccu cccaacgggc      720

ccuccucccc uccuugcacc gagauuaaua aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa      780

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaugcaucc cccccccccc cccccccccc      840

ccccccccca aaggcucuuu ucagagccac cagaauu                               877


<210>  268
<211>  874
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  IL12A(1-219) mRNA product opt10

<400>  268
gggagaaagc uuaccaugug ccccgcccgu ucacuccucc ucgucgccac ccucguccuc       60

cuagaccacc ucucccuggc ccgcaaccuc ccagucgcca cccccgaccc cggcauguuc      120

cccugccucc accacuccca aaaccuccuc cgcgccgucu ccaacaugcu ccaaaaagcc      180

cgccaaaccc ucgaauuuua ccccugcacc uccgaagaga ucgaccacga agacaucacc      240

aaagacaaaa ccuccacagu cgaagccugc cucccccucg aacucaccaa aaacgaaucc      300

ugccuuaacu cccgcgaaac cuccuucauc accaacggcu ccugccucgc cucccgcaaa      360

accuccuuca ugauggcccu cugccucucc uccaucuacg aagaccucaa aauguaccaa      420

gucgaauuua aaaccaugaa cgccaaacuc cucauggacc ccaaacgcca aaucuuccuc      480

gaccaaaaca ugcucgccgu caucgacgaa cucaugcaag cccucaacuu caacuccgaa      540

accguccccc aaaaauccuc ccucgaagaa cccgacuucu acaaaaccaa aaucaaacuu      600

ugcauccucc uccacgcauu ccgcauccgc gccgucacca ucgaccgugu caugagcuac      660

cuaaacgccu ccggacuagu uauaagacug acuagcccga ugggccuccc aacgggcccu      720

ccuccccucc uugcaccgag auuaauaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa      780

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa ugcauccccc cccccccccc cccccccccc      840

ccccccaaag gcucuuuuca gagccaccag aauu                                  874


<210>  269
<211>  811
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  IL12A(23-219) mRNA product opt10

<400>  269
gggagaaagc uuacccgcaa ccucccaguc gccacccccg accccggcau guuccccugc       60

cuccaccacu cccaaaaccu ccuccgcgcc gucuccaaca ugcuccaaaa agcccgccaa      120

acccucgaau uuuaccccug caccuccgaa gagaucgacc acgaagacau caccaaagac      180

aaaaccucca cagucgaagc cugccucccc cucgaacuca ccaaaaacga auccugccuu      240

aacucccgcg aaaccuccuu caucaccaac ggcuccugcc ucgccucccg caaaaccucc      300

uucaugaugg cccucugccu cuccuccauc uacgaagacc ucaaaaugua ccaagucgaa      360

uuuaaaacca ugaacgccaa acuccucaug gaccccaaac gccaaaucuu ccucgaccaa      420

aacaugcucg ccgucaucga cgaacucaug caagcccuca acuucaacuc cgaaaccguc      480

ccccaaaaau ccucccucga agaacccgac uucuacaaaa ccaaaaucaa acuuugcauc      540

cuccuccacg cauuccgcau ccgcgccguc accaucgacc gugucaugag cuaccuaaac      600

gccuccugag gacuaguuau aagacugacu agcccgaugg gccucccaac gggcccuccu      660

ccccuccuug caccgagauu aauaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa      720

aaaaaaaaaa aaaaaaaaaa aaaaaaaugc aucccccccc cccccccccc cccccccccc      780

cccaaaggcu cuuuucagag ccaccagaau u                                     811


<210>  270
<211>  1204
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  IL12B mRNA product opt10

<400>  270
gggagaaagc uuaccaugug ccaccaacaa cucgucaucu ccugguucuc ccucgucuuc       60

cuagccuccc cacucgucgc caucugggaa cucaaaaaag acguauacgu cgucgaacuc      120

gacugguacc ccgacgcccc aggagaaaug gucguccuaa ccugcgacac acccgaagaa      180

gacgguauca ccuggacccu cgaccaaucc uccgaagucc uaggcuccgg caagacccuc      240

accauccaag ucaaagaauu uggcgacgca ggacaauaca ccugucacaa aggcggcgaa      300

guccucagcc acagccuucu ccuacuccau aaaaaagaag acggcaucug guccacugac      360

auccucaaag accaaaaaga acccaaaaau aaaaccuucc uccgcugcga agccaaaaac      420

uacuccggcc gauucaccug uugguggcua accacaauca gcaccgaccu caccuucuca      480

gucaaauccu cccgcggcuc aucugacccc caaggcguca caugcggcgc cgccacccuc      540

uccgccgaac gcguccgcgg cgacaacaaa gaauacgaau acuccgucga augucaagaa      600

gacuccgccu gccccgccgc cgaagaauca cuccccaucg aagucauggu cgacgcaguc      660

cacaaacuca aauacgaaaa cuacaccucc uccuucuuca uccgcgacau aauaaaaccc      720

gacccaccca aaaaccucca acucaagcca cucaaaaacu cccgacaagu cgaagucucc      780

ugggaguacc ccgacaccug guccacacca cacuccuacu ucucccucac cuucugcguc      840

caaguccaag gcaaauccaa acgcgaaaaa aaagaccgcg uuuucacaga caaaaccucc      900

gccacaguaa uaugccgcaa aaacgccucc aucuccgucc gggcccaaga ccgcuacuac      960

uccuccuccu gguccgagug ggccucaguc cccugcagcu aaggacuagu uauaagacug     1020

acuagcccga ugggccuccc aacgggcccu ccuccccucc uugcaccgag auuaauaaaa     1080

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa     1140

ugcauccccc cccccccccc cccccccccc ccccccaaag gcucuuuuca gagccaccag     1200

aauu                                                                  1204


<210>  271
<211>  1201
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  IL12B(1-328) mRNA product opt10

<400>  271
gggagaaagc uuaccaugug ccaccaacaa cucgucaucu ccugguucuc ccucgucuuc       60

cuagccuccc cacucgucgc caucugggaa cucaaaaaag acguauacgu cgucgaacuc      120

gacugguacc ccgacgcccc aggagaaaug gucguccuaa ccugcgacac acccgaagaa      180

gacgguauca ccuggacccu cgaccaaucc uccgaagucc uaggcuccgg caagacccuc      240

accauccaag ucaaagaauu uggcgacgca ggacaauaca ccugucacaa aggcggcgaa      300

guccucagcc acagccuucu ccuacuccau aaaaaagaag acggcaucug guccacugac      360

auccucaaag accaaaaaga acccaaaaau aaaaccuucc uccgcugcga agccaaaaac      420

uacuccggcc gauucaccug uugguggcua accacaauca gcaccgaccu caccuucuca      480

gucaaauccu cccgcggcuc aucugacccc caaggcguca caugcggcgc cgccacccuc      540

uccgccgaac gcguccgcgg cgacaacaaa gaauacgaau acuccgucga augucaagaa      600

gacuccgccu gccccgccgc cgaagaauca cuccccaucg aagucauggu cgacgcaguc      660

cacaaacuca aauacgaaaa cuacaccucc uccuucuuca uccgcgacau aauaaaaccc      720

gacccaccca aaaaccucca acucaagcca cucaaaaacu cccgacaagu cgaagucucc      780

ugggaguacc ccgacaccug guccacacca cacuccuacu ucucccucac cuucugcguc      840

caaguccaag gcaaauccaa acgcgaaaaa aaagaccgcg uuuucacaga caaaaccucc      900

gccacaguaa uaugccgcaa aaacgccucc aucuccgucc gggcccaaga ccgcuacuac      960

uccuccuccu gguccgagug ggccucaguc cccugcagcg gacuaguuau aagacugacu     1020

agcccgaugg gccucccaac gggcccuccu ccccuccuug caccgagauu aauaaaaaaa     1080

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaugc     1140

aucccccccc cccccccccc cccccccccc cccaaaggcu cuuuucagag ccaccagaau     1200

u                                                                     1201


<210>  272
<211>  1138
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  IL12B(23-328) mRNA product opt10

<400>  272
gggagaaagc uuaccaucug ggaacucaaa aaagacguau acgucgucga acucgacugg       60

uaccccgacg ccccaggaga aauggucguc cuaaccugcg acacacccga agaagacggu      120

aucaccugga cccucgacca auccuccgaa guccuaggcu ccggcaagac ccucaccauc      180

caagucaaag aauuuggcga cgcaggacaa uacaccuguc acaaaggcgg cgaaguccuc      240

agccacagcc uucuccuacu ccauaaaaaa gaagacggca ucugguccac ugacauccuc      300

aaagaccaaa aagaacccaa aaauaaaacc uuccuccgcu gcgaagccaa aaacuacucc      360

ggccgauuca ccuguuggug gcuaaccaca aucagcaccg accucaccuu cucagucaaa      420

uccucccgcg gcucaucuga cccccaaggc gucacaugcg gcgccgccac ccucuccgcc      480

gaacgcgucc gcggcgacaa caaagaauac gaauacuccg ucgaauguca agaagacucc      540

gccugccccg ccgccgaaga aucacucccc aucgaaguca uggucgacgc aguccacaaa      600

cucaaauacg aaaacuacac cuccuccuuc uucauccgcg acauaauaaa acccgaccca      660

cccaaaaacc uccaacucaa gccacucaaa aacucccgac aagucgaagu cuccugggag      720

uaccccgaca ccugguccac accacacucc uacuucuccc ucaccuucug cguccaaguc      780

caaggcaaau ccaaacgcga aaaaaaagac cgcguuuuca cagacaaaac cuccgccaca      840

guaauaugcc gcaaaaacgc cuccaucucc guccgggccc aagaccgcua cuacuccucc      900

uccugguccg agugggccuc aguccccugc agcuaaggac uaguuauaag acugacuagc      960

ccgaugggcc ucccaacggg cccuccuccc cuccuugcac cgagauuaau aaaaaaaaaa     1020

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaugcauc     1080

cccccccccc cccccccccc cccccccccc aaaggcucuu uucagagcca ccagaauu       1138


<210>  273
<211>  271
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Linker-sFvCC49-218 mRNA product opt10

<400>  273
gggagaaagc uuaccgggag uacgaguggg agugggaagc cggggagugg ggaggggagu       60

acgaaggggg gacuaguuau aagacugacu agcccgaugg gccucccaac gggcccuccu      120

ccccuccuug caccgagauu aauaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa      180

aaaaaaaaaa aaaaaaaaaa aaaaaaaugc aucccccccc cccccccccc cccccccccc      240

cccaaaggcu cuuuucagag ccaccagaau u                                     271


<210>  274
<211>  1849
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  IL12 mRNA product opt10

<400>  274
gggagaaagc uuaccaugug ccaccaacaa cucgucaucu ccugguucuc ccucgucuuc       60

cuagccuccc cacucgucgc caucugggaa cucaaaaaag acguauacgu cgucgaacuc      120

gacugguacc ccgacgcccc aggagaaaug gucguccuaa ccugcgacac acccgaagaa      180

gacgguauca ccuggacccu cgaccaaucc uccgaagucc uaggcuccgg caagacccuc      240

accauccaag ucaaagaauu uggcgacgca ggacaauaca ccugucacaa aggcggcgaa      300

guccucagcc acagccuucu ccuacuccau aaaaaagaag acggcaucug guccacugac      360

auccucaaag accaaaaaga acccaaaaau aaaaccuucc uccgcugcga agccaaaaac      420

uacuccggcc gauucaccug uugguggcua accacaauca gcaccgaccu caccuucuca      480

gucaaauccu cccgcggcuc aucugacccc caaggcguca caugcggcgc cgccacccuc      540

uccgccgaac gcguccgcgg cgacaacaaa gaauacgaau acuccgucga augucaagaa      600

gacuccgccu gccccgccgc cgaagaauca cuccccaucg aagucauggu cgacgcaguc      660

cacaaacuca aauacgaaaa cuacaccucc uccuucuuca uccgcgacau aauaaaaccc      720

gacccaccca aaaaccucca acucaagcca cucaaaaacu cccgacaagu cgaagucucc      780

ugggaguacc ccgacaccug guccacacca cacuccuacu ucucccucac cuucugcguc      840

caaguccaag gcaaauccaa acgcgaaaaa aaagaccgcg uuuucacaga caaaaccucc      900

gccacaguaa uaugccgcaa aaacgccucc aucuccgucc gggcccaaga ccgcuacuac      960

uccuccuccu gguccgagug ggccucaguc cccugcagcg ggaguacgag ugggaguggg     1020

aagccgggga guggggaggg gaguacgaag gggcgcaacc ucccagucgc cacccccgac     1080

cccggcaugu uccccugccu ccaccacucc caaaaccucc uccgcgccgu cuccaacaug     1140

cuccaaaaag cccgccaaac ccucgaauuu uaccccugca ccuccgaaga gaucgaccac     1200

gaagacauca ccaaagacaa aaccuccaca gucgaagccu gccucccccu cgaacucacc     1260

aaaaacgaau ccugccuuaa cucccgcgaa accuccuuca ucaccaacgg cuccugccuc     1320

gccucccgca aaaccuccuu caugauggcc cucugccucu ccuccaucua cgaagaccuc     1380

aaaauguacc aagucgaauu uaaaaccaug aacgccaaac uccucaugga ccccaaacgc     1440

caaaucuucc ucgaccaaaa caugcucgcc gucaucgacg aacucaugca agcccucaac     1500

uucaacuccg aaaccguccc ccaaaaaucc ucccucgaag aacccgacuu cuacaaaacc     1560

aaaaucaaac uuugcauccu ccuccacgca uuccgcaucc gcgccgucac caucgaccgu     1620

gucaugagcu accuaaacgc cuccugagga cuaguuauaa gacugacuag cccgaugggc     1680

cucccaacgg gcccuccucc ccuccuugca ccgagauuaa uaaaaaaaaa aaaaaaaaaa     1740

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaugcau cccccccccc     1800

cccccccccc cccccccccc caaaggcucu uuucagagcc accagaauu                 1849


<210>  275
<211>  1003
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  CD40LG mRNA product opt10

<400>  275
gggagaaagc uuaccaugau cgaaaccuac aaucaaaccu ccccccgcag cgccgcaaca       60

ggccucccca ucuccaugaa aaucuucaug uaccuccuca ccgucuuccu aaucacccaa      120

augaucggcu ccgcccuauu cgccgucuac cuccaccgcc gccucgacaa aaucgaagac      180

gaacgcaacc uccacgaaga cuuugucuuc augaaaacua uccaacgaug caacaccggc      240

gaacgauccc uaucccuccu caacugcgaa gaaauaaaau cccaauucga aggauucguc      300

aaagacauca ugcuaaacaa agaagaaacc aaaaaagaaa acuccuucga aaugcaaaaa      360

ggcgaccaaa acccccaaau cgcagcccac gucaucucag aagcaucuuc caaaaccacc      420

uccguccucc aaugggccga aaaaggcuac uacaccaugu caaacaaccu cgucacccuc      480

gaaaacggca aacaacucac cgucaaacgc caaggccucu acuacaucua cgcacaaguc      540

accuucugcu ccaaccgcga agcauccucc caagcccccu ucaucgccuc ccucugccuc      600

aaaucccccg gccgcuucga acgcauccuc cuccgcgccg caaauaccca cuccuccgcc      660

aaaccaugcg gccaacaauc cauccaccuc ggcggcgucu ucgaacucca acccggcgcc      720

uccgucuucg ucaacgucac cgaccccucc caaguauccc auggaaccgg cuucaccucc      780

uucggccucc ucaaacucua gggacuaguu auaagacuga cuagcccgau gggccuccca      840

acgggcccuc cuccccuccu ugcaccgaga uuaauaaaaa aaaaaaaaaa aaaaaaaaaa      900

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaau gcaucccccc cccccccccc      960

cccccccccc cccccaaagg cucuuuucag agccaccaga auu                       1003


<210>  276
<211>  1249
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  PDCD1 mRNA product TOP UTR wild type

<400>  276
ggggcgcugc cuacggaggu ggcagccauc uccuucucgg caucaagcuu accaugcaga       60

ucccacaggc gcccuggcca gucgucuggg cggugcuaca acugggcugg cggccaggau      120

gguucuuaga cuccccagac aggcccugga acccccccac cuucucccca gcccugcucg      180

uggugaccga aggggacaac gccaccuuca ccugcagcuu cuccaacaca ucggagagcu      240

ucgugcuaaa cugguaccgc augagcccca gcaaccagac ggacaagcug gccgcuuucc      300

ccgaggaccg cagccagccc ggccaggacu gccgcuuccg ugucacacaa cugcccaacg      360

ggcgugacuu ccacaugagc guggucaggg cccggcgcaa ugacagcggc accuaccucu      420

guggggccau cucccuggcc cccaaggcgc agaucaaaga gagccugcgg gcagagcuca      480

gggugacaga gagaagggca gaagugccca cagcccaccc cagccccuca cccaggccag      540

ccggccaguu ccaaacccug gugguuggug ucgugggcgg ccugcugggc agccuggugc      600

ugcuagucug gguccuggcc gucaucugcu cccgggccgc acgagggaca auaggagcca      660

ggcgcaccgg ccagccccug aaggaggacc ccucagccgu gccuguguuc ucuguggacu      720

auggggagcu ggauuuccag uggcgagaga agaccccgga gccccccgug cccugugucc      780

cugagcagac ggaguaugcc accauugucu uuccuagcgg aaugggcacc ucaucccccg      840

cccgcagggg cucagccgac ggcccucgga gugcccagcc acugaggccu gaggauggac      900

acugcucuug gccccucuga ggacuagugc aucacauuua aaagcaucuc agccuaccau      960

gagaauaaga gaaagaaaau gaagaucaau agcuuauuca ucucuuuuuc uuuuucguug     1020

guguaaagcc aacacccugu cuaaaaaaca uaaauuucuu uaaucauuuu gccucuuuuc     1080

ucugugcuuc aauuaauaaa aaauggaaag aaccuagauc uaaaaaaaaa aaaaaaaaaa     1140

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaugcau cccccccccc     1200

cccccccccc cccccccccc caaaggcucu uuucagagcc accagaauu                 1249


<210>  277
<211>  832
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  PDCD1(1-149) mRNA product TOP UTR wild type

<400>  277
ggggcgcugc cuacggaggu ggcagccauc uccuucucgg caucaagcuu accaugcaga       60

ucccacaggc gcccuggcca gucgucuggg cggugcuaca acugggcugg cggccaggau      120

gguucuuaga cuccccagac aggcccugga acccccccac cuucucccca gcccugcucg      180

uggugaccga aggggacaac gccaccuuca ccugcagcuu cuccaacaca ucggagagcu      240

ucgugcuaaa cugguaccgc augagcccca gcaaccagac ggacaagcug gccgcuuucc      300

ccgaggaccg cagccagccc ggccaggacu gccgcuuccg ugucacacaa cugcccaacg      360

ggcgugacuu ccacaugagc guggucaggg cccggcgcaa ugacagcggc accuaccucu      420

guggggccau cucccuggcc cccaaggcgc agaucaaaga gagccugcgg gcagagcuca      480

gggugacaga gagaagggca ugaggacuag ugcaucacau uuaaaagcau cucagccuac      540

caugagaaua agagaaagaa aaugaagauc aauagcuuau ucaucucuuu uucuuuuucg      600

uugguguaaa gccaacaccc ugucuaaaaa acauaaauuu cuuuaaucau uuugccucuu      660

uucucugugc uucaauuaau aaaaaaugga aagaaccuag aucuaaaaaa aaaaaaaaaa      720

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaug cauccccccc      780

cccccccccc cccccccccc ccccaaaggc ucuuuucaga gccaccagaa uu              832


<210>  278
<211>  1042
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  IL12A mRNA product TOP UTR wild type

<400>  278
ggggcgcugc cuacggaggu ggcagccauc uccuucucgg caucaagcuu accauguguc       60

cagcgcgcag ccuccuccuu guggcuaccc ugguccuccu ggaccaccuc aguuuggcca      120

gaaaccuccc cguggccacu ccagacccag gaauguuccc augccuucac cacucccaaa      180

accugcugag ggccgucagc aacaugcucc agaaggccag acaaacucua gaauuuuacc      240

cuugcacuuc ugaagagauu gaucaugaag auaucacaaa agauaaaacc agcacagugg      300

aggccuguuu accauuggaa uuaaccaaga augagaguug ccuaaauucc agagagaccu      360

cuuucauaac uaaugggagu ugccuggccu ccagaaagac cucuuuuaug auggcccugu      420

gccuuaguag uauuuaugaa gacuugaaga uguaccaggu ggaguucaag accaugaaug      480

caaagcuucu gauggauccu aagaggcaga ucuuucuaga ucaaaacaug cuggcaguua      540

uugaugagcu gaugcaggcc cugaauuuca acagugagac ugugccacaa aaauccuccc      600

uugaagaacc ggauuuuuau aaaacuaaaa ucaagcucug cauacuucuu caugcuuuca      660

gaauucgggc agugacuauu gauagaguga ugagcuaucu gaaugcuucc uaaggacuag      720

ugcaucacau uuaaaagcau cucagccuac caugagaaua agagaaagaa aaugaagauc      780

aauagcuuau ucaucucuuu uucuuuuucg uugguguaaa gccaacaccc ugucuaaaaa      840

acauaaauuu cuuuaaucau uuugccucuu uucucugugc uucaauuaau aaaaaaugga      900

aagaaccuag aucuaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa      960

aaaaaaaaaa aaaaaaaaug cauccccccc cccccccccc cccccccccc ccccaaaggc     1020

ucuuuucaga gccaccagaa uu                                              1042


<210>  279
<211>  1039
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  IL12A(1-219) mRNA product TOP UTR wild type

<400>  279
ggggcgcugc cuacggaggu ggcagccauc uccuucucgg caucaagcuu accauguguc       60

cagcgcgcag ccuccuccuu guggcuaccc ugguccuccu ggaccaccuc aguuuggcca      120

gaaaccuccc cguggccacu ccagacccag gaauguuccc augccuucac cacucccaaa      180

accugcugag ggccgucagc aacaugcucc agaaggccag acaaacucua gaauuuuacc      240

cuugcacuuc ugaagagauu gaucaugaag auaucacaaa agauaaaacc agcacagugg      300

aggccuguuu accauuggaa uuaaccaaga augagaguug ccuaaauucc agagagaccu      360

cuuucauaac uaaugggagu ugccuggccu ccagaaagac cucuuuuaug auggcccugu      420

gccuuaguag uauuuaugaa gacuugaaga uguaccaggu ggaguucaag accaugaaug      480

caaagcuucu gauggauccu aagaggcaga ucuuucuaga ucaaaacaug cuggcaguua      540

uugaugagcu gaugcaggcc cugaauuuca acagugagac ugugccacaa aaauccuccc      600

uugaagaacc ggauuuuuau aaaacuaaaa ucaagcucug cauacuucuu caugcuuuca      660

gaauucgggc agugacuauu gauagaguga ugagcuaucu gaaugcuucc ggacuagugc      720

aucacauuua aaagcaucuc agccuaccau gagaauaaga gaaagaaaau gaagaucaau      780

agcuuauuca ucucuuuuuc uuuuucguug guguaaagcc aacacccugu cuaaaaaaca      840

uaaauuucuu uaaucauuuu gccucuuuuc ucugugcuuc aauuaauaaa aaauggaaag      900

aaccuagauc uaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa      960

aaaaaaaaaa aaaaaugcau cccccccccc cccccccccc cccccccccc caaaggcucu     1020

uuucagagcc accagaauu                                                  1039


<210>  280
<211>  976
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  IL12A(23-219) mRNA product TOP UTR wild type

<400>  280
ggggcgcugc cuacggaggu ggcagccauc uccuucucgg caucaagcuu accagaaacc       60

uccccguggc cacuccagac ccaggaaugu ucccaugccu ucaccacucc caaaaccugc      120

ugagggccgu cagcaacaug cuccagaagg ccagacaaac ucuagaauuu uacccuugca      180

cuucugaaga gauugaucau gaagauauca caaaagauaa aaccagcaca guggaggccu      240

guuuaccauu ggaauuaacc aagaaugaga guugccuaaa uuccagagag accucuuuca      300

uaacuaaugg gaguugccug gccuccagaa agaccucuuu uaugauggcc cugugccuua      360

guaguauuua ugaagacuug aagauguacc agguggaguu caagaccaug aaugcaaagc      420

uucugaugga uccuaagagg cagaucuuuc uagaucaaaa caugcuggca guuauugaug      480

agcugaugca ggcccugaau uucaacagug agacugugcc acaaaaaucc ucccuugaag      540

aaccggauuu uuauaaaacu aaaaucaagc ucugcauacu ucuucaugcu uucagaauuc      600

gggcagugac uauugauaga gugaugagcu aucugaaugc uuccuaagga cuagugcauc      660

acauuuaaaa gcaucucagc cuaccaugag aauaagagaa agaaaaugaa gaucaauagc      720

uuauucaucu cuuuuucuuu uucguuggug uaaagccaac acccugucua aaaaacauaa      780

auuucuuuaa ucauuuugcc ucuuuucucu gugcuucaau uaauaaaaaa uggaaagaac      840

cuagaucuaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa      900

aaaaaaaaaa aaugcauccc cccccccccc cccccccccc ccccccccaa aggcucuuuu      960

cagagccacc agaauu                                                      976


<210>  281
<211>  1369
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  IL12B mRNA product TOP UTR wild type

<400>  281
ggggcgcugc cuacggaggu ggcagccauc uccuucucgg caucaagcuu accauguguc       60

accagcaguu ggucaucucu ugguuuuccc ugguuuuucu ggcaucuccc cucguggcca      120

uaugggaacu gaagaaagau guuuaugucg uagaauugga uugguauccg gaugccccug      180

gagaaauggu gguccucacc ugugacaccc cugaagaaga ugguaucacc uggaccuugg      240

accagagcag ugaggucuua ggcucuggca aaacccugac cauccaaguc aaagaguuug      300

gagaugcugg ccaguacacc ugucacaaag gaggcgaggu ucuaagccau ucgcuccugc      360

ugcuucacaa aaaggaagau ggaauuuggu ccacugauau uuuaaaggac cagaaagaac      420

ccaaaaauaa gaccuuucua agaugcgagg ccaagaauua uucuggacgu uucaccugcu      480

gguggcugac gacaaucagu acugauuuga cauucagugu caaaagcagc agaggcucuu      540

cugaccccca aggggugacg ugcggagcug cuacacucuc ugcagagaga gucagagggg      600

acaacaagga guaugaguac ucaguggagu gccaggagga cagugccugc ccagcugcug      660

aggagagucu gcccauugag gucauggugg augccguuca caagcucaag uaugaaaacu      720

acaccagcag cuucuucauc agggacauca ucaaaccuga cccacccaag aacuugcagc      780

ugaagccauu aaagaauucu cggcaggugg aggucagcug ggaguacccu gacaccugga      840

guacuccaca uuccuacuuc ucccugacau ucugcguuca gguccagggc aagagcaaga      900

gagaaaagaa agauagaguc uucacggaca agaccucagc cacggucauc ugccgcaaaa      960

augccagcau uagcgugcgg gcccaggacc gcuacuauag cucaucuugg agcgaauggg     1020

caucugugcc cugcaguuag ggacuagugc aucacauuua aaagcaucuc agccuaccau     1080

gagaauaaga gaaagaaaau gaagaucaau agcuuauuca ucucuuuuuc uuuuucguug     1140

guguaaagcc aacacccugu cuaaaaaaca uaaauuucuu uaaucauuuu gccucuuuuc     1200

ucugugcuuc aauuaauaaa aaauggaaag aaccuagauc uaaaaaaaaa aaaaaaaaaa     1260

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaugcau cccccccccc     1320

cccccccccc cccccccccc caaaggcucu uuucagagcc accagaauu                 1369


<210>  282
<211>  1366
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  IL12B(1-328) mRNA product TOP UTR wild type

<400>  282
ggggcgcugc cuacggaggu ggcagccauc uccuucucgg caucaagcuu accauguguc       60

accagcaguu ggucaucucu ugguuuuccc ugguuuuucu ggcaucuccc cucguggcca      120

uaugggaacu gaagaaagau guuuaugucg uagaauugga uugguauccg gaugccccug      180

gagaaauggu gguccucacc ugugacaccc cugaagaaga ugguaucacc uggaccuugg      240

accagagcag ugaggucuua ggcucuggca aaacccugac cauccaaguc aaagaguuug      300

gagaugcugg ccaguacacc ugucacaaag gaggcgaggu ucuaagccau ucgcuccugc      360

ugcuucacaa aaaggaagau ggaauuuggu ccacugauau uuuaaaggac cagaaagaac      420

ccaaaaauaa gaccuuucua agaugcgagg ccaagaauua uucuggacgu uucaccugcu      480

gguggcugac gacaaucagu acugauuuga cauucagugu caaaagcagc agaggcucuu      540

cugaccccca aggggugacg ugcggagcug cuacacucuc ugcagagaga gucagagggg      600

acaacaagga guaugaguac ucaguggagu gccaggagga cagugccugc ccagcugcug      660

aggagagucu gcccauugag gucauggugg augccguuca caagcucaag uaugaaaacu      720

acaccagcag cuucuucauc agggacauca ucaaaccuga cccacccaag aacuugcagc      780

ugaagccauu aaagaauucu cggcaggugg aggucagcug ggaguacccu gacaccugga      840

guacuccaca uuccuacuuc ucccugacau ucugcguuca gguccagggc aagagcaaga      900

gagaaaagaa agauagaguc uucacggaca agaccucagc cacggucauc ugccgcaaaa      960

augccagcau uagcgugcgg gcccaggacc gcuacuauag cucaucuugg agcgaauggg     1020

caucugugcc cugcagugga cuagugcauc acauuuaaaa gcaucucagc cuaccaugag     1080

aauaagagaa agaaaaugaa gaucaauagc uuauucaucu cuuuuucuuu uucguuggug     1140

uaaagccaac acccugucua aaaaacauaa auuucuuuaa ucauuuugcc ucuuuucucu     1200

gugcuucaau uaauaaaaaa uggaaagaac cuagaucuaa aaaaaaaaaa aaaaaaaaaa     1260

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaugcauccc cccccccccc     1320

cccccccccc ccccccccaa aggcucuuuu cagagccacc agaauu                    1366


<210>  283
<211>  1303
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  IL12B(23-328) mRNA product TOP UTR wild type

<400>  283
ggggcgcugc cuacggaggu ggcagccauc uccuucucgg caucaagcuu accauauggg       60

aacugaagaa agauguuuau gucguagaau uggauuggua uccggaugcc ccuggagaaa      120

uggugguccu caccugugac accccugaag aagaugguau caccuggacc uuggaccaga      180

gcagugaggu cuuaggcucu ggcaaaaccc ugaccaucca agucaaagag uuuggagaug      240

cuggccagua caccugucac aaaggaggcg agguucuaag ccauucgcuc cugcugcuuc      300

acaaaaagga agauggaauu ugguccacug auauuuuaaa ggaccagaaa gaacccaaaa      360

auaagaccuu ucuaagaugc gaggccaaga auuauucugg acguuucacc ugcugguggc      420

ugacgacaau caguacugau uugacauuca gugucaaaag cagcagaggc ucuucugacc      480

cccaaggggu gacgugcgga gcugcuacac ucucugcaga gagagucaga ggggacaaca      540

aggaguauga guacucagug gagugccagg aggacagugc cugcccagcu gcugaggaga      600

gucugcccau ugaggucaug guggaugccg uucacaagcu caaguaugaa aacuacacca      660

gcagcuucuu caucagggac aucaucaaac cugacccacc caagaacuug cagcugaagc      720

cauuaaagaa uucucggcag guggagguca gcugggagua cccugacacc uggaguacuc      780

cacauuccua cuucucccug acauucugcg uucaggucca gggcaagagc aagagagaaa      840

agaaagauag agucuucacg gacaagaccu cagccacggu caucugccgc aaaaaugcca      900

gcauuagcgu gcgggcccag gaccgcuacu auagcucauc uuggagcgaa ugggcaucug      960

ugcccugcag uuagggacua gugcaucaca uuuaaaagca ucucagccua ccaugagaau     1020

aagagaaaga aaaugaagau caauagcuua uucaucucuu uuucuuuuuc guugguguaa     1080

agccaacacc cugucuaaaa aacauaaauu ucuuuaauca uuuugccucu uuucucugug     1140

cuucaauuaa uaaaaaaugg aaagaaccua gaucuaaaaa aaaaaaaaaa aaaaaaaaaa     1200

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaau gcaucccccc cccccccccc     1260

cccccccccc cccccaaagg cucuuuucag agccaccaga auu                       1303


<210>  284
<211>  436
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Linker-sFvCC49-218 mRNA product TOP UTR wild type

<400>  284
ggggcgcugc cuacggaggu ggcagccauc uccuucucgg caucaagcuu accggcagua       60

cuucgggcag ugguaagccu gguaguggug aggguaguac uaagggugga cuagugcauc      120

acauuuaaaa gcaucucagc cuaccaugag aauaagagaa agaaaaugaa gaucaauagc      180

uuauucaucu cuuuuucuuu uucguuggug uaaagccaac acccugucua aaaaacauaa      240

auuucuuuaa ucauuuugcc ucuuuucucu gugcuucaau uaauaaaaaa uggaaagaac      300

cuagaucuaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa      360

aaaaaaaaaa aaugcauccc cccccccccc cccccccccc ccccccccaa aggcucuuuu      420

cagagccacc agaauu                                                      436


<210>  285
<211>  2014
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  IL12 mRNA product TOP UTR wild type

<400>  285
ggggcgcugc cuacggaggu ggcagccauc uccuucucgg caucaagcuu accauguguc       60

accagcaguu ggucaucucu ugguuuuccc ugguuuuucu ggcaucuccc cucguggcca      120

uaugggaacu gaagaaagau guuuaugucg uagaauugga uugguauccg gaugccccug      180

gagaaauggu gguccucacc ugugacaccc cugaagaaga ugguaucacc uggaccuugg      240

accagagcag ugaggucuua ggcucuggca aaacccugac cauccaaguc aaagaguuug      300

gagaugcugg ccaguacacc ugucacaaag gaggcgaggu ucuaagccau ucgcuccugc      360

ugcuucacaa aaaggaagau ggaauuuggu ccacugauau uuuaaaggac cagaaagaac      420

ccaaaaauaa gaccuuucua agaugcgagg ccaagaauua uucuggacgu uucaccugcu      480

gguggcugac gacaaucagu acugauuuga cauucagugu caaaagcagc agaggcucuu      540

cugaccccca aggggugacg ugcggagcug cuacacucuc ugcagagaga gucagagggg      600

acaacaagga guaugaguac ucaguggagu gccaggagga cagugccugc ccagcugcug      660

aggagagucu gcccauugag gucauggugg augccguuca caagcucaag uaugaaaacu      720

acaccagcag cuucuucauc agggacauca ucaaaccuga cccacccaag aacuugcagc      780

ugaagccauu aaagaauucu cggcaggugg aggucagcug ggaguacccu gacaccugga      840

guacuccaca uuccuacuuc ucccugacau ucugcguuca gguccagggc aagagcaaga      900

gagaaaagaa agauagaguc uucacggaca agaccucagc cacggucauc ugccgcaaaa      960

augccagcau uagcgugcgg gcccaggacc gcuacuauag cucaucuugg agcgaauggg     1020

caucugugcc cugcaguggc aguacuucgg gcagugguaa gccugguagu ggugagggua     1080

guacuaaggg uagaaaccuc cccguggcca cuccagaccc aggaauguuc ccaugccuuc     1140

accacuccca aaaccugcug agggccguca gcaacaugcu ccagaaggcc agacaaacuc     1200

uagaauuuua cccuugcacu ucugaagaga uugaucauga agauaucaca aaagauaaaa     1260

ccagcacagu ggaggccugu uuaccauugg aauuaaccaa gaaugagagu ugccuaaauu     1320

ccagagagac cucuuucaua acuaauggga guugccuggc cuccagaaag accucuuuua     1380

ugauggcccu gugccuuagu aguauuuaug aagacuugaa gauguaccag guggaguuca     1440

agaccaugaa ugcaaagcuu cugauggauc cuaagaggca gaucuuucua gaucaaaaca     1500

ugcuggcagu uauugaugag cugaugcagg cccugaauuu caacagugag acugugccac     1560

aaaaauccuc ccuugaagaa ccggauuuuu auaaaacuaa aaucaagcuc ugcauacuuc     1620

uucaugcuuu cagaauucgg gcagugacua uugauagagu gaugagcuau cugaaugcuu     1680

ccuaaggacu agugcaucac auuuaaaagc aucucagccu accaugagaa uaagagaaag     1740

aaaaugaaga ucaauagcuu auucaucucu uuuucuuuuu cguuggugua aagccaacac     1800

ccugucuaaa aaacauaaau uucuuuaauc auuuugccuc uuuucucugu gcuucaauua     1860

auaaaaaaug gaaagaaccu agaucuaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa     1920

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa ugcauccccc cccccccccc cccccccccc     1980

ccccccaaag gcucuuuuca gagccaccag aauu                                 2014


<210>  286
<211>  1168
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  CD40LG mRNA product TOP UTR wild type

<400>  286
ggggcgcugc cuacggaggu ggcagccauc uccuucucgg caucaagcuu accaugaucg       60

aaacauacaa ccaaacuucu ccccgaucug cggccacugg acugcccauc agcaugaaaa      120

uuuuuaugua uuuacuuacu guuuuucuua ucacccagau gauuggguca gcacuuuuug      180

cuguguaucu ucauagaagg uuggacaaga uagaagauga aaggaaucuu caugaagauu      240

uuguauucau gaaaacgaua cagagaugca acacaggaga aagauccuua uccuuacuga      300

acugugagga gauuaaaagc caguuugaag gcuuugugaa ggauauaaug uuaaacaaag      360

aggagacgaa gaaagaaaac agcuuugaaa ugcaaaaagg ugaucagaau ccucaaauug      420

cggcacaugu cauaagugag gccagcagua aaacaacauc uguguuacag ugggcugaaa      480

aaggauacua caccaugagc aacaacuugg uaacccugga aaaugggaaa cagcugaccg      540

uuaaaagaca aggacucuau uauaucuaug cccaagucac cuucuguucc aaucgggaag      600

cuucgaguca agcuccauuu auagccagcc ucugccuaaa gucccccggu agauucgaga      660

gaaucuuacu cagagcugca aauacccaca guuccgccaa accuugcggg caacaaucca      720

uucacuuggg aggaguauuu gaauugcaac caggugcuuc gguguuuguc aaugugacug      780

auccaagcca agugagccau ggcacuggcu ucacguccuu uggcuuacuc aaacucugag      840

gacuagugca ucacauuuaa aagcaucuca gccuaccaug agaauaagag aaagaaaaug      900

aagaucaaua gcuuauucau cucuuuuucu uuuucguugg uguaaagcca acacccuguc      960

uaaaaaacau aaauuucuuu aaucauuuug ccucuuuucu cugugcuuca auuaauaaaa     1020

aauggaaaga accuagaucu aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa     1080

aaaaaaaaaa aaaaaaaaaa aaaaugcauc cccccccccc cccccccccc cccccccccc     1140

aaaggcucuu uucagagcca ccagaauu                                        1168


<210>  287
<211>  1249
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  PDCD1 mRNA product TOP UTR opt1

<400>  287
ggggcgcugc cuacggaggu ggcagccauc uccuucucgg caucaagcuu accaugcaga       60

ucccccaggc cccguggccc guggucuggg ccgugcugca gcucggcugg cgccccgggu      120

gguuccugga cagccccgac cggccgugga acccgcccac cuucuccccc gcgcugcucg      180

uggucaccga gggcgacaac gccacguuca cgugcagcuu cuccaacacc agcgaguccu      240

ucgugcugaa cugguaccgc augagccccu ccaaccagac cgacaagcug gccgccuucc      300

ccgaggaccg gagccagccc gggcaggacu gccgcuuccg ggugacccag cuccccaacg      360

gccgcgacuu ccacaugucc gucgugcggg cccgccggaa cgacagcggg accuaccugu      420

gcggcgcgau cucccuggcc ccgaaggccc agaucaagga gagccuccgc gccgagcugc      480

gggugaccga gcgccgggcg gaggucccca ccgcccaccc cucccccagc ccgcgccccg      540

ccggccaguu ccagacgcug gugguggggg ucgugggcgg gcuccugggc ucccuggugc      600

uccuggucug ggugcuggcc gugaucugca gccgggccgc gcgcgggacc aucggcgccc      660

ggcgcaccgg ccagccccuc aaggaggacc ccuccgccgu cccgguguuc agcguggacu      720

acggggagcu ggacuuccag uggcgggaga agacccccga gccgcccguc cccugcgugc      780

ccgagcagac ggaguacgcc accaucgugu uccccuccgg cauggggacc agcagccccg      840

cccgccgggg cuccgcggac ggcccgcgca gcgcccagcc ccugcgcccc gaggacgggc      900

acugcuccug gccgcucuga ggacuagugc aucacauuua aaagcaucuc agccuaccau      960

gagaauaaga gaaagaaaau gaagaucaau agcuuauuca ucucuuuuuc uuuuucguug     1020

guguaaagcc aacacccugu cuaaaaaaca uaaauuucuu uaaucauuuu gccucuuuuc     1080

ucugugcuuc aauuaauaaa aaauggaaag aaccuagauc uaaaaaaaaa aaaaaaaaaa     1140

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaugcau cccccccccc     1200

cccccccccc cccccccccc caaaggcucu uuucagagcc accagaauu                 1249


<210>  288
<211>  832
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  PDCD1(1-149) mRNA product TOP UTR opt1

<400>  288
ggggcgcugc cuacggaggu ggcagccauc uccuucucgg caucaagcuu accaugcaga       60

ucccccaggc cccguggccc guggucuggg ccgugcugca gcucggcugg cgccccgggu      120

gguuccugga cagccccgac cggccgugga acccgcccac cuucuccccc gcgcugcucg      180

uggucaccga gggcgacaac gccacguuca cgugcagcuu cuccaacacc agcgaguccu      240

ucgugcugaa cugguaccgc augagccccu ccaaccagac cgacaagcug gccgccuucc      300

ccgaggaccg gagccagccc gggcaggacu gccgcuuccg ggugacccag cuccccaacg      360

gccgcgacuu ccacaugucc gucgugcggg cccgccggaa cgacagcggg accuaccugu      420

gcggcgcgau cucccuggcc ccgaaggccc agaucaagga gagccuccgc gccgagcugc      480

gggugaccga gcgccgggcg ugaggacuag ugcaucacau uuaaaagcau cucagccuac      540

caugagaaua agagaaagaa aaugaagauc aauagcuuau ucaucucuuu uucuuuuucg      600

uugguguaaa gccaacaccc ugucuaaaaa acauaaauuu cuuuaaucau uuugccucuu      660

uucucugugc uucaauuaau aaaaaaugga aagaaccuag aucuaaaaaa aaaaaaaaaa      720

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaug cauccccccc      780

cccccccccc cccccccccc ccccaaaggc ucuuuucaga gccaccagaa uu              832


<210>  289
<211>  1042
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  IL12A mRNA product TOP UTR opt1

<400>  289
ggggcgcugc cuacggaggu ggcagccauc uccuucucgg caucaagcuu accaugugcc       60

ccgcccgcag ccugcuccug guggccaccc ugguccuccu ggaccaccug ucccucgcgc      120

ggaaccugcc gguggccacc cccgaccccg gcauguuccc cugccugcac cacagccaga      180

accuccugcg cgccgugucc aacaugcugc agaaggcccg gcagacgcuc gaguucuacc      240

cgugcaccag cgaggagauc gaccacgagg acaucaccaa ggacaagacc uccacggucg      300

aggccugccu gccccuggag cucaccaaga acgagagcug ccugaacucc cgcgagacca      360

gcuucaucac caacgggucc ugccuggcga gccggaagac guccuucaug auggcccucu      420

gccugagcuc caucuacgag gaccugaaga uguaccaggu ggaguucaag accaugaacg      480

ccaagcuccu gauggacccc aagcgccaga ucuuccugga ccagaacaug cucgccguga      540

ucgacgagcu gaugcaggcg cugaacuuca acagcgagac cgucccccag aaguccagcc      600

ucgaggagcc ggacuucuac aagaccaaga ucaagcugug cauccugcuc cacgccuucc      660

ggauccgcgc cgugacgauc gaccggguga uguccuaccu gaacgccagc ugaggacuag      720

ugcaucacau uuaaaagcau cucagccuac caugagaaua agagaaagaa aaugaagauc      780

aauagcuuau ucaucucuuu uucuuuuucg uugguguaaa gccaacaccc ugucuaaaaa      840

acauaaauuu cuuuaaucau uuugccucuu uucucugugc uucaauuaau aaaaaaugga      900

aagaaccuag aucuaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa      960

aaaaaaaaaa aaaaaaaaug cauccccccc cccccccccc cccccccccc ccccaaaggc     1020

ucuuuucaga gccaccagaa uu                                              1042


<210>  290
<211>  1039
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  IL12A(1-219) mRNA product TOP UTR opt1

<400>  290
ggggcgcugc cuacggaggu ggcagccauc uccuucucgg caucaagcuu accaugugcc       60

ccgcccgcag ccugcuccug guggccaccc ugguccuccu ggaccaccug ucccucgcgc      120

ggaaccugcc gguggccacc cccgaccccg gcauguuccc cugccugcac cacagccaga      180

accuccugcg cgccgugucc aacaugcugc agaaggcccg gcagacgcuc gaguucuacc      240

cgugcaccag cgaggagauc gaccacgagg acaucaccaa ggacaagacc uccacggucg      300

aggccugccu gccccuggag cucaccaaga acgagagcug ccugaacucc cgcgagacca      360

gcuucaucac caacgggucc ugccuggcga gccggaagac guccuucaug auggcccucu      420

gccugagcuc caucuacgag gaccugaaga uguaccaggu ggaguucaag accaugaacg      480

ccaagcuccu gauggacccc aagcgccaga ucuuccugga ccagaacaug cucgccguga      540

ucgacgagcu gaugcaggcg cugaacuuca acagcgagac cgucccccag aaguccagcc      600

ucgaggagcc ggacuucuac aagaccaaga ucaagcugug cauccugcuc cacgccuucc      660

ggauccgcgc cgugacgauc gaccggguga uguccuaccu gaacgccagc ggacuagugc      720

aucacauuua aaagcaucuc agccuaccau gagaauaaga gaaagaaaau gaagaucaau      780

agcuuauuca ucucuuuuuc uuuuucguug guguaaagcc aacacccugu cuaaaaaaca      840

uaaauuucuu uaaucauuuu gccucuuuuc ucugugcuuc aauuaauaaa aaauggaaag      900

aaccuagauc uaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa      960

aaaaaaaaaa aaaaaugcau cccccccccc cccccccccc cccccccccc caaaggcucu     1020

uuucagagcc accagaauu                                                  1039


<210>  291
<211>  976
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  IL12A(23-219) mRNA product TOP UTR opt1

<400>  291
ggggcgcugc cuacggaggu ggcagccauc uccuucucgg caucaagcuu acccggaacc       60

ugccgguggc cacccccgac cccggcaugu uccccugccu gcaccacagc cagaaccucc      120

ugcgcgccgu guccaacaug cugcagaagg cccggcagac gcucgaguuc uacccgugca      180

ccagcgagga gaucgaccac gaggacauca ccaaggacaa gaccuccacg gucgaggccu      240

gccugccccu ggagcucacc aagaacgaga gcugccugaa cucccgcgag accagcuuca      300

ucaccaacgg guccugccug gcgagccgga agacguccuu caugauggcc cucugccuga      360

gcuccaucua cgaggaccug aagauguacc agguggaguu caagaccaug aacgccaagc      420

uccugaugga ccccaagcgc cagaucuucc uggaccagaa caugcucgcc gugaucgacg      480

agcugaugca ggcgcugaac uucaacagcg agaccguccc ccagaagucc agccucgagg      540

agccggacuu cuacaagacc aagaucaagc ugugcauccu gcuccacgcc uuccggaucc      600

gcgccgugac gaucgaccgg gugauguccu accugaacgc cagcugagga cuagugcauc      660

acauuuaaaa gcaucucagc cuaccaugag aauaagagaa agaaaaugaa gaucaauagc      720

uuauucaucu cuuuuucuuu uucguuggug uaaagccaac acccugucua aaaaacauaa      780

auuucuuuaa ucauuuugcc ucuuuucucu gugcuucaau uaauaaaaaa uggaaagaac      840

cuagaucuaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa      900

aaaaaaaaaa aaugcauccc cccccccccc cccccccccc ccccccccaa aggcucuuuu      960

cagagccacc agaauu                                                      976


<210>  292
<211>  1369
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  IL12B mRNA product TOP UTR opt1

<400>  292
ggggcgcugc cuacggaggu ggcagccauc uccuucucgg caucaagcuu accaugugcc       60

accagcagcu ggugaucagc ugguucuccc ucgucuuccu ggccagcccc cugguggcca      120

ucugggagcu caagaaggac guguacgucg uggagcugga cugguacccg gacgcgcccg      180

gcgagauggu gguccugacc ugcgacaccc ccgaggagga cgggaucacg uggacccucg      240

accaguccag cgaggugcug ggcuccggga agacccugac cauccaggug aaggaguucg      300

gcgacgccgg gcaguacacg ugccacaagg gcggcgaggu ccucagccac ucccugcugc      360

uccugcacaa gaaggaggac gggaucugga gcaccgacau ccugaaggac cagaaggagc      420

ccaagaacaa gaccuuccuc cgcugcgagg ccaagaacua cuccggccgg uucacgugcu      480

gguggcugac caccaucagc accgaccuga ccuucuccgu caagagcucc cgcgggagcu      540

ccgacccgca gggcgugacg ugcggggccg ccacccucag cgcggagcgg gugcgcggcg      600

acaacaagga guacgaguac uccguggagu gccaggagga cagcgccugc cccgccgccg      660

aggagucccu gcccaucgag gugauggucg acgcggugca caagcugaag uacgagaacu      720

acaccagcag cuucuucauc cgggacauca ucaagcccga cccgcccaag aaccuccagc      780

ugaagccccu gaagaacucc cgccaggugg aggucagcug ggaguacccc gacaccuggu      840

ccacgccgca cagcuacuuc ucccucaccu ucugcgucca ggugcagggc aagagcaagc      900

gggagaagaa ggaccgcgug uucaccgaca agaccuccgc cacggugauc ugccggaaga      960

acgccagcau cuccgugcgc gcccaggacc gguacuacag cuccagcugg uccgaguggg     1020

ccagcguccc cugcuccuga ggacuagugc aucacauuua aaagcaucuc agccuaccau     1080

gagaauaaga gaaagaaaau gaagaucaau agcuuauuca ucucuuuuuc uuuuucguug     1140

guguaaagcc aacacccugu cuaaaaaaca uaaauuucuu uaaucauuuu gccucuuuuc     1200

ucugugcuuc aauuaauaaa aaauggaaag aaccuagauc uaaaaaaaaa aaaaaaaaaa     1260

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaugcau cccccccccc     1320

cccccccccc cccccccccc caaaggcucu uuucagagcc accagaauu                 1369


<210>  293
<211>  1366
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  IL12B(1-328) mRNA product TOP UTR opt1

<400>  293
ggggcgcugc cuacggaggu ggcagccauc uccuucucgg caucaagcuu accaugugcc       60

accagcagcu ggugaucagc ugguucuccc ucgucuuccu ggccagcccc cugguggcca      120

ucugggagcu caagaaggac guguacgucg uggagcugga cugguacccg gacgcgcccg      180

gcgagauggu gguccugacc ugcgacaccc ccgaggagga cgggaucacg uggacccucg      240

accaguccag cgaggugcug ggcuccggga agacccugac cauccaggug aaggaguucg      300

gcgacgccgg gcaguacacg ugccacaagg gcggcgaggu ccucagccac ucccugcugc      360

uccugcacaa gaaggaggac gggaucugga gcaccgacau ccugaaggac cagaaggagc      420

ccaagaacaa gaccuuccuc cgcugcgagg ccaagaacua cuccggccgg uucacgugcu      480

gguggcugac caccaucagc accgaccuga ccuucuccgu caagagcucc cgcgggagcu      540

ccgacccgca gggcgugacg ugcggggccg ccacccucag cgcggagcgg gugcgcggcg      600

acaacaagga guacgaguac uccguggagu gccaggagga cagcgccugc cccgccgccg      660

aggagucccu gcccaucgag gugauggucg acgcggugca caagcugaag uacgagaacu      720

acaccagcag cuucuucauc cgggacauca ucaagcccga cccgcccaag aaccuccagc      780

ugaagccccu gaagaacucc cgccaggugg aggucagcug ggaguacccc gacaccuggu      840

ccacgccgca cagcuacuuc ucccucaccu ucugcgucca ggugcagggc aagagcaagc      900

gggagaagaa ggaccgcgug uucaccgaca agaccuccgc cacggugauc ugccggaaga      960

acgccagcau cuccgugcgc gcccaggacc gguacuacag cuccagcugg uccgaguggg     1020

ccagcguccc cugcuccgga cuagugcauc acauuuaaaa gcaucucagc cuaccaugag     1080

aauaagagaa agaaaaugaa gaucaauagc uuauucaucu cuuuuucuuu uucguuggug     1140

uaaagccaac acccugucua aaaaacauaa auuucuuuaa ucauuuugcc ucuuuucucu     1200

gugcuucaau uaauaaaaaa uggaaagaac cuagaucuaa aaaaaaaaaa aaaaaaaaaa     1260

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaugcauccc cccccccccc     1320

cccccccccc ccccccccaa aggcucuuuu cagagccacc agaauu                    1366


<210>  294
<211>  1303
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  IL12B(23-328) mRNA product TOP UTR opt1

<400>  294
ggggcgcugc cuacggaggu ggcagccauc uccuucucgg caucaagcuu accaucuggg       60

agcucaagaa ggacguguac gucguggagc uggacuggua cccggacgcg cccggcgaga      120

uggugguccu gaccugcgac acccccgagg aggacgggau cacguggacc cucgaccagu      180

ccagcgaggu gcugggcucc gggaagaccc ugaccaucca ggugaaggag uucggcgacg      240

ccgggcagua cacgugccac aagggcggcg agguccucag ccacucccug cugcuccugc      300

acaagaagga ggacgggauc uggagcaccg acauccugaa ggaccagaag gagcccaaga      360

acaagaccuu ccuccgcugc gaggccaaga acuacuccgg ccgguucacg ugcugguggc      420

ugaccaccau cagcaccgac cugaccuucu ccgucaagag cucccgcggg agcuccgacc      480

cgcagggcgu gacgugcggg gccgccaccc ucagcgcgga gcgggugcgc ggcgacaaca      540

aggaguacga guacuccgug gagugccagg aggacagcgc cugccccgcc gccgaggagu      600

cccugcccau cgaggugaug gucgacgcgg ugcacaagcu gaaguacgag aacuacacca      660

gcagcuucuu cauccgggac aucaucaagc ccgacccgcc caagaaccuc cagcugaagc      720

cccugaagaa cucccgccag guggagguca gcugggagua ccccgacacc ugguccacgc      780

cgcacagcua cuucucccuc accuucugcg uccaggugca gggcaagagc aagcgggaga      840

agaaggaccg cguguucacc gacaagaccu ccgccacggu gaucugccgg aagaacgcca      900

gcaucuccgu gcgcgcccag gaccgguacu acagcuccag cugguccgag ugggccagcg      960

uccccugcuc cugaggacua gugcaucaca uuuaaaagca ucucagccua ccaugagaau     1020

aagagaaaga aaaugaagau caauagcuua uucaucucuu uuucuuuuuc guugguguaa     1080

agccaacacc cugucuaaaa aacauaaauu ucuuuaauca uuuugccucu uuucucugug     1140

cuucaauuaa uaaaaaaugg aaagaaccua gaucuaaaaa aaaaaaaaaa aaaaaaaaaa     1200

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaau gcaucccccc cccccccccc     1260

cccccccccc cccccaaagg cucuuuucag agccaccaga auu                       1303


<210>  295
<211>  436
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Linker-sFvCC49-218 mRNA product TOP UTR opt1

<400>  295
ggggcgcugc cuacggaggu ggcagccauc uccuucucgg caucaagcuu accggcagca       60

ccuccgggag cggcaagccc ggguccggcg aggggagcac caagggcgga cuagugcauc      120

acauuuaaaa gcaucucagc cuaccaugag aauaagagaa agaaaaugaa gaucaauagc      180

uuauucaucu cuuuuucuuu uucguuggug uaaagccaac acccugucua aaaaacauaa      240

auuucuuuaa ucauuuugcc ucuuuucucu gugcuucaau uaauaaaaaa uggaaagaac      300

cuagaucuaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa      360

aaaaaaaaaa aaugcauccc cccccccccc cccccccccc ccccccccaa aggcucuuuu      420

cagagccacc agaauu                                                      436


<210>  296
<211>  2014
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  IL12 mRNA product TOP UTR opt1

<400>  296
ggggcgcugc cuacggaggu ggcagccauc uccuucucgg caucaagcuu accaugugcc       60

accagcagcu ggugaucagc ugguucuccc ucgucuuccu ggccagcccc cugguggcca      120

ucugggagcu caagaaggac guguacgucg uggagcugga cugguacccg gacgcgcccg      180

gcgagauggu gguccugacc ugcgacaccc ccgaggagga cgggaucacg uggacccucg      240

accaguccag cgaggugcug ggcuccggga agacccugac cauccaggug aaggaguucg      300

gcgacgccgg gcaguacacg ugccacaagg gcggcgaggu ccucagccac ucccugcugc      360

uccugcacaa gaaggaggac gggaucugga gcaccgacau ccugaaggac cagaaggagc      420

ccaagaacaa gaccuuccuc cgcugcgagg ccaagaacua cuccggccgg uucacgugcu      480

gguggcugac caccaucagc accgaccuga ccuucuccgu caagagcucc cgcgggagcu      540

ccgacccgca gggcgugacg ugcggggccg ccacccucag cgcggagcgg gugcgcggcg      600

acaacaagga guacgaguac uccguggagu gccaggagga cagcgccugc cccgccgccg      660

aggagucccu gcccaucgag gugauggucg acgcggugca caagcugaag uacgagaacu      720

acaccagcag cuucuucauc cgggacauca ucaagcccga cccgcccaag aaccuccagc      780

ugaagccccu gaagaacucc cgccaggugg aggucagcug ggaguacccc gacaccuggu      840

ccacgccgca cagcuacuuc ucccucaccu ucugcgucca ggugcagggc aagagcaagc      900

gggagaagaa ggaccgcgug uucaccgaca agaccuccgc cacggugauc ugccggaaga      960

acgccagcau cuccgugcgc gcccaggacc gguacuacag cuccagcugg uccgaguggg     1020

ccagcguccc cugcuccggc agcaccuccg ggagcggcaa gcccgggucc ggcgagggga     1080

gcaccaaggg ccggaaccug ccgguggcca cccccgaccc cggcauguuc cccugccugc     1140

accacagcca gaaccuccug cgcgccgugu ccaacaugcu gcagaaggcc cggcagacgc     1200

ucgaguucua cccgugcacc agcgaggaga ucgaccacga ggacaucacc aaggacaaga     1260

ccuccacggu cgaggccugc cugccccugg agcucaccaa gaacgagagc ugccugaacu     1320

cccgcgagac cagcuucauc accaacgggu ccugccuggc gagccggaag acguccuuca     1380

ugauggcccu cugccugagc uccaucuacg aggaccugaa gauguaccag guggaguuca     1440

agaccaugaa cgccaagcuc cugauggacc ccaagcgcca gaucuuccug gaccagaaca     1500

ugcucgccgu gaucgacgag cugaugcagg cgcugaacuu caacagcgag accguccccc     1560

agaaguccag ccucgaggag ccggacuucu acaagaccaa gaucaagcug ugcauccugc     1620

uccacgccuu ccggauccgc gccgugacga ucgaccgggu gauguccuac cugaacgcca     1680

gcugaggacu agugcaucac auuuaaaagc aucucagccu accaugagaa uaagagaaag     1740

aaaaugaaga ucaauagcuu auucaucucu uuuucuuuuu cguuggugua aagccaacac     1800

ccugucuaaa aaacauaaau uucuuuaauc auuuugccuc uuuucucugu gcuucaauua     1860

auaaaaaaug gaaagaaccu agaucuaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa     1920

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa ugcauccccc cccccccccc cccccccccc     1980

ccccccaaag gcucuuuuca gagccaccag aauu                                 2014


<210>  297
<211>  1168
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  CD40LG mRNA product TOP UTR opt1

<400>  297
ggggcgcugc cuacggaggu ggcagccauc uccuucucgg caucaagcuu accaugaucg       60

agaccuacaa ccagaccagc ccccgcuccg ccgccacggg ccugccgauc agcaugaaga      120

ucuucaugua ccuccugacc guguuccuga ucacccagau gaucgggucc gcgcuguucg      180

ccgucuaccu gcaccggcgc cuggacaaga ucgaggacga gcggaaccuc cacgaggacu      240

ucguguucau gaagaccauc cagcgcugca acacgggcga gcggagccug ucccugcuca      300

acugcgagga gaucaagagc caguucgagg gguucgugaa ggacaucaug cugaacaagg      360

aggagaccaa gaaggagaac uccuucgaga ugcagaaggg cgaccagaac ccccagaucg      420

ccgcccacgu caucagcgag gccuccagca agaccaccuc cgugcugcag ugggcggaga      480

agggguacua cacgaugagc aacaaccucg ugacccugga gaacggcaag cagcugaccg      540

ucaagcgcca gggccucuac uacaucuacg cccaggugac cuucugcucc aaccgggagg      600

ccagcuccca ggcccccuuc aucgcgagcc ugugccugaa gucccccggg cgcuucgagc      660

ggauccuccu gcgcgccgcc aacacgcaca gcuccgccaa gccgugcggc cagcagagca      720

uccaccucgg gggcguguuc gagcuccagc ccggggccag cgucuucgug aacgugaccg      780

accccuccca ggucagccac ggcaccggcu ucaccuccuu cgggcugcug aagcucugag      840

gacuagugca ucacauuuaa aagcaucuca gccuaccaug agaauaagag aaagaaaaug      900

aagaucaaua gcuuauucau cucuuuuucu uuuucguugg uguaaagcca acacccuguc      960

uaaaaaacau aaauuucuuu aaucauuuug ccucuuuucu cugugcuuca auuaauaaaa     1020

aauggaaaga accuagaucu aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa     1080

aaaaaaaaaa aaaaaaaaaa aaaaugcauc cccccccccc cccccccccc cccccccccc     1140

aaaggcucuu uucagagcca ccagaauu                                        1168


<210>  298
<211>  1249
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  PDCD1 mRNA product TOP UTR opt2

<400>  298
ggggcgcugc cuacggaggu ggcagccauc uccuucucgg caucaagcuu accaugcaga       60

ucccccaggc ccccuggccc gucgucuggg ccguccucca gcucggcugg cgccccggcu      120

gguuccucga cucccccgac cgccccugga acccccccac cuucuccccc gcccuccucg      180

ucgucaccga gggcgacaac gccaccuuca ccuguuccuu cuccaacacc uccgaguccu      240

ucguccucaa cugguaccgc augucccccu ccaaccagac cgacaagcuc gccgccuucc      300

ccgaggaccg cucccagccc ggccaggacu gccgcuuccg cgucacccag cuccccaacg      360

gccgcgacuu ccacaugucc gucguccgcg cccgccgcaa cgacuccggc accuaccucu      420

gcggcgccau cucccucgcc cccaaggccc agaucaagga gucccuccgc gccgagcucc      480

gcgucaccga gcgccgcgcc gaggucccca ccgcccaccc cucccccucc ccccgccccg      540

ccggccaguu ccagacccuc gucgucggcg ucgucggcgg ccuccucggc ucccucgucc      600

uccucgucug gguccucgcc gucaucugcu cccgcgccgc ccgcggcacc aucggcgccc      660

gccgcaccgg ccagccccuc aaggaggacc ccuccgccgu ccccgucuuc uccgucgacu      720

acggcgagcu cgacuuccag uggcgcgaga agacccccga gccccccguc cccugcgucc      780

ccgagcagac cgaguacgcc accaucgucu uccccuccgg caugggcacc uccucccccg      840

cccgccgcgg cuccgccgac ggcccccgcu ccgcccagcc ccuccgcccc gaggacggcc      900

acugcuccug gccccucuga ggacuagugc aucacauuua aaagcaucuc agccuaccau      960

gagaauaaga gaaagaaaau gaagaucaau agcuuauuca ucucuuuuuc uuuuucguug     1020

guguaaagcc aacacccugu cuaaaaaaca uaaauuucuu uaaucauuuu gccucuuuuc     1080

ucugugcuuc aauuaauaaa aaauggaaag aaccuagauc uaaaaaaaaa aaaaaaaaaa     1140

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaugcau cccccccccc     1200

cccccccccc cccccccccc caaaggcucu uuucagagcc accagaauu                 1249


<210>  299
<211>  832
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  PDCD1(1-149) mRNA product TOP UTR opt2

<400>  299
ggggcgcugc cuacggaggu ggcagccauc uccuucucgg caucaagcuu accaugcaga       60

ucccccaggc ccccuggccc gucgucuggg ccguccucca gcucggcugg cgccccggcu      120

gguuccucga cucccccgac cgccccugga acccccccac cuucuccccc gcccuccucg      180

ucgucaccga gggcgacaac gccaccuuca ccuguuccuu cuccaacacc uccgaguccu      240

ucguccucaa cugguaccgc augucccccu ccaaccagac cgacaagcuc gccgccuucc      300

ccgaggaccg cucccagccc ggccaggacu gccgcuuccg cgucacccag cuccccaacg      360

gccgcgacuu ccacaugucc gucguccgcg cccgccgcaa cgacuccggc accuaccucu      420

gcggcgccau cucccucgcc cccaaggccc agaucaagga gucccuccgc gccgagcucc      480

gcgucaccga gcgccgcgcc ugaggacuag ugcaucacau uuaaaagcau cucagccuac      540

caugagaaua agagaaagaa aaugaagauc aauagcuuau ucaucucuuu uucuuuuucg      600

uugguguaaa gccaacaccc ugucuaaaaa acauaaauuu cuuuaaucau uuugccucuu      660

uucucugugc uucaauuaau aaaaaaugga aagaaccuag aucuaaaaaa aaaaaaaaaa      720

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaug cauccccccc      780

cccccccccc cccccccccc ccccaaaggc ucuuuucaga gccaccagaa uu              832


<210>  300
<211>  1042
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  IL12A mRNA product TOP UTR opt2

<400>  300
ggggcgcugc cuacggaggu ggcagccauc uccuucucgg caucaagcuu accaugugcc       60

ccgcccgcuc ccuccuccuc gucgccaccc ucguccuccu cgaccaccuc ucccucgccc      120

gcaaccuccc cgucgccacc cccgaccccg gcauguuccc cugccuccac cacucccaga      180

accuccuccg cgccgucucc aacaugcucc agaaggcccg ccagacccuc gaguucuacc      240

ccugcaccuc cgaggagauc gaccacgagg acaucaccaa ggacaagacc uccaccgucg      300

aggccugccu cccccucgag cucaccaaga acgaguccug ccucaacucc cgcgagaccu      360

ccuucaucac caacggcucc ugccucgccu cccgcaagac cuccuucaug auggcccucu      420

gccucuccuc caucuacgag gaccucaaga uguaccaggu cgaguucaag accaugaacg      480

ccaagcuccu cauggacccc aagcgccaga ucuuccucga ccagaacaug cucgccguca      540

ucgacgagcu caugcaggcc cucaacuuca acuccgagac cgucccccag aaguccuccc      600

ucgaggagcc cgacuucuac aagaccaaga ucaagcucug cauccuccuc cacgccuucc      660

gcauccgcgc cgucaccauc gaccgcguca uguccuaccu caacgccucc ugaggacuag      720

ugcaucacau uuaaaagcau cucagccuac caugagaaua agagaaagaa aaugaagauc      780

aauagcuuau ucaucucuuu uucuuuuucg uugguguaaa gccaacaccc ugucuaaaaa      840

acauaaauuu cuuuaaucau uuugccucuu uucucugugc uucaauuaau aaaaaaugga      900

aagaaccuag aucuaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa      960

aaaaaaaaaa aaaaaaaaug cauccccccc cccccccccc cccccccccc ccccaaaggc     1020

ucuuuucaga gccaccagaa uu                                              1042


<210>  301
<211>  1039
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  IL12A(1-219) mRNA product TOP UTR opt2

<400>  301
ggggcgcugc cuacggaggu ggcagccauc uccuucucgg caucaagcuu accaugugcc       60

ccgcccgcuc ccuccuccuc gucgccaccc ucguccuccu cgaccaccuc ucccucgccc      120

gcaaccuccc cgucgccacc cccgaccccg gcauguuccc cugccuccac cacucccaga      180

accuccuccg cgccgucucc aacaugcucc agaaggcccg ccagacccuc gaguucuacc      240

ccugcaccuc cgaggagauc gaccacgagg acaucaccaa ggacaagacc uccaccgucg      300

aggccugccu cccccucgag cucaccaaga acgaguccug ccucaacucc cgcgagaccu      360

ccuucaucac caacggcucc ugccucgccu cccgcaagac cuccuucaug auggcccucu      420

gccucuccuc caucuacgag gaccucaaga uguaccaggu cgaguucaag accaugaacg      480

ccaagcuccu cauggacccc aagcgccaga ucuuccucga ccagaacaug cucgccguca      540

ucgacgagcu caugcaggcc cucaacuuca acuccgagac cgucccccag aaguccuccc      600

ucgaggagcc cgacuucuac aagaccaaga ucaagcucug cauccuccuc cacgccuucc      660

gcauccgcgc cgucaccauc gaccgcguca uguccuaccu caacgccucc ggacuagugc      720

aucacauuua aaagcaucuc agccuaccau gagaauaaga gaaagaaaau gaagaucaau      780

agcuuauuca ucucuuuuuc uuuuucguug guguaaagcc aacacccugu cuaaaaaaca      840

uaaauuucuu uaaucauuuu gccucuuuuc ucugugcuuc aauuaauaaa aaauggaaag      900

aaccuagauc uaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa      960

aaaaaaaaaa aaaaaugcau cccccccccc cccccccccc cccccccccc caaaggcucu     1020

uuucagagcc accagaauu                                                  1039


<210>  302
<211>  976
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  IL12A(23-219) mRNA product TOP UTR opt2

<400>  302
ggggcgcugc cuacggaggu ggcagccauc uccuucucgg caucaagcuu acccgcaacc       60

uccccgucgc cacccccgac cccggcaugu uccccugccu ccaccacucc cagaaccucc      120

uccgcgccgu cuccaacaug cuccagaagg cccgccagac ccucgaguuc uaccccugca      180

ccuccgagga gaucgaccac gaggacauca ccaaggacaa gaccuccacc gucgaggccu      240

gccucccccu cgagcucacc aagaacgagu ccugccucaa cucccgcgag accuccuuca      300

ucaccaacgg cuccugccuc gccucccgca agaccuccuu caugauggcc cucugccucu      360

ccuccaucua cgaggaccuc aagauguacc aggucgaguu caagaccaug aacgccaagc      420

uccucaugga ccccaagcgc cagaucuucc ucgaccagaa caugcucgcc gucaucgacg      480

agcucaugca ggcccucaac uucaacuccg agaccguccc ccagaagucc ucccucgagg      540

agcccgacuu cuacaagacc aagaucaagc ucugcauccu ccuccacgcc uuccgcaucc      600

gcgccgucac caucgaccgc gucauguccu accucaacgc cuccugagga cuagugcauc      660

acauuuaaaa gcaucucagc cuaccaugag aauaagagaa agaaaaugaa gaucaauagc      720

uuauucaucu cuuuuucuuu uucguuggug uaaagccaac acccugucua aaaaacauaa      780

auuucuuuaa ucauuuugcc ucuuuucucu gugcuucaau uaauaaaaaa uggaaagaac      840

cuagaucuaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa      900

aaaaaaaaaa aaugcauccc cccccccccc cccccccccc ccccccccaa aggcucuuuu      960

cagagccacc agaauu                                                      976


<210>  303
<211>  1369
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  IL12B mRNA product TOP UTR opt2

<400>  303
ggggcgcugc cuacggaggu ggcagccauc uccuucucgg caucaagcuu accaugugcc       60

accagcagcu cgucaucucc ugguucuccc ucgucuuccu cgccuccccc cucgucgcca      120

ucugggagcu caagaaggac gucuacgucg ucgagcucga cugguacccc gacgcccccg      180

gcgagauggu cguccucacc ugugacaccc ccgaggagga cggcaucacc uggacccucg      240

accaguccuc cgagguccuc ggcuccggca agacccucac cauccagguc aaggaguucg      300

gcgacgccgg ccaguacacc ugucacaagg gcggcgaggu ccucucccac ucccuccucc      360

uccuccacaa gaaggaggac ggcaucuggu ccaccgacau ccucaaggac cagaaggagc      420

ccaagaacaa gaccuuccuc cgcugcgagg ccaagaacua cuccggccgc uucaccuguu      480

gguggcucac caccaucucc accgaccuca ccuucuccgu caaguccucc cgcggcuccu      540

ccgaccccca gggcgucacc uguggcgccg ccacccucuc cgccgagcgc guccgcggcg      600

acaacaagga guacgaguac uccgucgagu gccaggagga cuccgccugc cccgccgccg      660

aggagucccu ccccaucgag gucauggucg acgccgucca caagcucaag uacgagaacu      720

acaccuccuc cuucuucauc cgcgacauca ucaagcccga cccccccaag aaccuccagc      780

ucaagccccu caagaacucc cgccaggucg aggucuccug ggaguacccc gacaccuggu      840

ccacccccca cuccuacuuc ucccucaccu ucugcgucca gguccagggc aaguccaagc      900

gcgagaagaa ggaccgcguc uucaccgaca agaccuccgc caccgucauc ugccgcaaga      960

acgccuccau cuccguccgc gcccaggacc gcuacuacuc cuccuccugg uccgaguggg     1020

ccuccguccc cugcuccuga ggacuagugc aucacauuua aaagcaucuc agccuaccau     1080

gagaauaaga gaaagaaaau gaagaucaau agcuuauuca ucucuuuuuc uuuuucguug     1140

guguaaagcc aacacccugu cuaaaaaaca uaaauuucuu uaaucauuuu gccucuuuuc     1200

ucugugcuuc aauuaauaaa aaauggaaag aaccuagauc uaaaaaaaaa aaaaaaaaaa     1260

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaugcau cccccccccc     1320

cccccccccc cccccccccc caaaggcucu uuucagagcc accagaauu                 1369


<210>  304
<211>  1366
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  IL12B(1-328) mRNA product TOP UTR opt2

<400>  304
ggggcgcugc cuacggaggu ggcagccauc uccuucucgg caucaagcuu accaugugcc       60

accagcagcu cgucaucucc ugguucuccc ucgucuuccu cgccuccccc cucgucgcca      120

ucugggagcu caagaaggac gucuacgucg ucgagcucga cugguacccc gacgcccccg      180

gcgagauggu cguccucacc ugugacaccc ccgaggagga cggcaucacc uggacccucg      240

accaguccuc cgagguccuc ggcuccggca agacccucac cauccagguc aaggaguucg      300

gcgacgccgg ccaguacacc ugucacaagg gcggcgaggu ccucucccac ucccuccucc      360

uccuccacaa gaaggaggac ggcaucuggu ccaccgacau ccucaaggac cagaaggagc      420

ccaagaacaa gaccuuccuc cgcugcgagg ccaagaacua cuccggccgc uucaccuguu      480

gguggcucac caccaucucc accgaccuca ccuucuccgu caaguccucc cgcggcuccu      540

ccgaccccca gggcgucacc uguggcgccg ccacccucuc cgccgagcgc guccgcggcg      600

acaacaagga guacgaguac uccgucgagu gccaggagga cuccgccugc cccgccgccg      660

aggagucccu ccccaucgag gucauggucg acgccgucca caagcucaag uacgagaacu      720

acaccuccuc cuucuucauc cgcgacauca ucaagcccga cccccccaag aaccuccagc      780

ucaagccccu caagaacucc cgccaggucg aggucuccug ggaguacccc gacaccuggu      840

ccacccccca cuccuacuuc ucccucaccu ucugcgucca gguccagggc aaguccaagc      900

gcgagaagaa ggaccgcguc uucaccgaca agaccuccgc caccgucauc ugccgcaaga      960

acgccuccau cuccguccgc gcccaggacc gcuacuacuc cuccuccugg uccgaguggg     1020

ccuccguccc cugcuccgga cuagugcauc acauuuaaaa gcaucucagc cuaccaugag     1080

aauaagagaa agaaaaugaa gaucaauagc uuauucaucu cuuuuucuuu uucguuggug     1140

uaaagccaac acccugucua aaaaacauaa auuucuuuaa ucauuuugcc ucuuuucucu     1200

gugcuucaau uaauaaaaaa uggaaagaac cuagaucuaa aaaaaaaaaa aaaaaaaaaa     1260

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaugcauccc cccccccccc     1320

cccccccccc ccccccccaa aggcucuuuu cagagccacc agaauu                    1366


<210>  305
<211>  1303
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  IL12B(23-328) mRNA product TOP UTR opt2

<400>  305
ggggcgcugc cuacggaggu ggcagccauc uccuucucgg caucaagcuu accaucuggg       60

agcucaagaa ggacgucuac gucgucgagc ucgacuggua ccccgacgcc cccggcgaga      120

uggucguccu caccugugac acccccgagg aggacggcau caccuggacc cucgaccagu      180

ccuccgaggu ccucggcucc ggcaagaccc ucaccaucca ggucaaggag uucggcgacg      240

ccggccagua caccugucac aagggcggcg agguccucuc ccacucccuc cuccuccucc      300

acaagaagga ggacggcauc ugguccaccg acauccucaa ggaccagaag gagcccaaga      360

acaagaccuu ccuccgcugc gaggccaaga acuacuccgg ccgcuucacc uguugguggc      420

ucaccaccau cuccaccgac cucaccuucu ccgucaaguc cucccgcggc uccuccgacc      480

cccagggcgu caccuguggc gccgccaccc ucuccgccga gcgcguccgc ggcgacaaca      540

aggaguacga guacuccguc gagugccagg aggacuccgc cugccccgcc gccgaggagu      600

cccuccccau cgaggucaug gucgacgccg uccacaagcu caaguacgag aacuacaccu      660

ccuccuucuu cauccgcgac aucaucaagc ccgacccccc caagaaccuc cagcucaagc      720

cccucaagaa cucccgccag gucgaggucu ccugggagua ccccgacacc ugguccaccc      780

cccacuccua cuucucccuc accuucugcg uccaggucca gggcaagucc aagcgcgaga      840

agaaggaccg cgucuucacc gacaagaccu ccgccaccgu caucugccgc aagaacgccu      900

ccaucuccgu ccgcgcccag gaccgcuacu acuccuccuc cugguccgag ugggccuccg      960

uccccugcuc cugaggacua gugcaucaca uuuaaaagca ucucagccua ccaugagaau     1020

aagagaaaga aaaugaagau caauagcuua uucaucucuu uuucuuuuuc guugguguaa     1080

agccaacacc cugucuaaaa aacauaaauu ucuuuaauca uuuugccucu uuucucugug     1140

cuucaauuaa uaaaaaaugg aaagaaccua gaucuaaaaa aaaaaaaaaa aaaaaaaaaa     1200

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaau gcaucccccc cccccccccc     1260

cccccccccc cccccaaagg cucuuuucag agccaccaga auu                       1303


<210>  306
<211>  436
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Linker-sFvCC49-218 mRNA product TOP UTR opt2

<400>  306
ggggcgcugc cuacggaggu ggcagccauc uccuucucgg caucaagcuu accggcucca       60

ccuccggcuc cggcaagccc ggcuccggcg agggcuccac caagggcgga cuagugcauc      120

acauuuaaaa gcaucucagc cuaccaugag aauaagagaa agaaaaugaa gaucaauagc      180

uuauucaucu cuuuuucuuu uucguuggug uaaagccaac acccugucua aaaaacauaa      240

auuucuuuaa ucauuuugcc ucuuuucucu gugcuucaau uaauaaaaaa uggaaagaac      300

cuagaucuaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa      360

aaaaaaaaaa aaugcauccc cccccccccc cccccccccc ccccccccaa aggcucuuuu      420

cagagccacc agaauu                                                      436


<210>  307
<211>  2014
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  IL12 mRNA product TOP UTR opt2

<400>  307
ggggcgcugc cuacggaggu ggcagccauc uccuucucgg caucaagcuu accaugugcc       60

accagcagcu cgucaucucc ugguucuccc ucgucuuccu cgccuccccc cucgucgcca      120

ucugggagcu caagaaggac gucuacgucg ucgagcucga cugguacccc gacgcccccg      180

gcgagauggu cguccucacc ugugacaccc ccgaggagga cggcaucacc uggacccucg      240

accaguccuc cgagguccuc ggcuccggca agacccucac cauccagguc aaggaguucg      300

gcgacgccgg ccaguacacc ugucacaagg gcggcgaggu ccucucccac ucccuccucc      360

uccuccacaa gaaggaggac ggcaucuggu ccaccgacau ccucaaggac cagaaggagc      420

ccaagaacaa gaccuuccuc cgcugcgagg ccaagaacua cuccggccgc uucaccuguu      480

gguggcucac caccaucucc accgaccuca ccuucuccgu caaguccucc cgcggcuccu      540

ccgaccccca gggcgucacc uguggcgccg ccacccucuc cgccgagcgc guccgcggcg      600

acaacaagga guacgaguac uccgucgagu gccaggagga cuccgccugc cccgccgccg      660

aggagucccu ccccaucgag gucauggucg acgccgucca caagcucaag uacgagaacu      720

acaccuccuc cuucuucauc cgcgacauca ucaagcccga cccccccaag aaccuccagc      780

ucaagccccu caagaacucc cgccaggucg aggucuccug ggaguacccc gacaccuggu      840

ccacccccca cuccuacuuc ucccucaccu ucugcgucca gguccagggc aaguccaagc      900

gcgagaagaa ggaccgcguc uucaccgaca agaccuccgc caccgucauc ugccgcaaga      960

acgccuccau cuccguccgc gcccaggacc gcuacuacuc cuccuccugg uccgaguggg     1020

ccuccguccc cugcuccggc uccaccuccg gcuccggcaa gcccggcucc ggcgagggcu     1080

ccaccaaggg ccgcaaccuc cccgucgcca cccccgaccc cggcauguuc cccugccucc     1140

accacuccca gaaccuccuc cgcgccgucu ccaacaugcu ccagaaggcc cgccagaccc     1200

ucgaguucua ccccugcacc uccgaggaga ucgaccacga ggacaucacc aaggacaaga     1260

ccuccaccgu cgaggccugc cucccccucg agcucaccaa gaacgagucc ugccucaacu     1320

cccgcgagac cuccuucauc accaacggcu ccugccucgc cucccgcaag accuccuuca     1380

ugauggcccu cugccucucc uccaucuacg aggaccucaa gauguaccag gucgaguuca     1440

agaccaugaa cgccaagcuc cucauggacc ccaagcgcca gaucuuccuc gaccagaaca     1500

ugcucgccgu caucgacgag cucaugcagg cccucaacuu caacuccgag accguccccc     1560

agaaguccuc ccucgaggag cccgacuucu acaagaccaa gaucaagcuc ugcauccucc     1620

uccacgccuu ccgcauccgc gccgucacca ucgaccgcgu cauguccuac cucaacgccu     1680

ccugaggacu agugcaucac auuuaaaagc aucucagccu accaugagaa uaagagaaag     1740

aaaaugaaga ucaauagcuu auucaucucu uuuucuuuuu cguuggugua aagccaacac     1800

ccugucuaaa aaacauaaau uucuuuaauc auuuugccuc uuuucucugu gcuucaauua     1860

auaaaaaaug gaaagaaccu agaucuaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa     1920

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa ugcauccccc cccccccccc cccccccccc     1980

ccccccaaag gcucuuuuca gagccaccag aauu                                 2014


<210>  308
<211>  1168
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  CD40LG mRNA product TOP UTR opt2

<400>  308
ggggcgcugc cuacggaggu ggcagccauc uccuucucgg caucaagcuu accaugaucg       60

agaccuacaa ccagaccucc ccccgcuccg ccgccaccgg ccuccccauc uccaugaaga      120

ucuucaugua ccuccucacc gucuuccuca ucacccagau gaucggcucc gcccucuucg      180

ccgucuaccu ccaccgccgc cucgacaaga ucgaggacga gcgcaaccuc cacgaggacu      240

ucgucuucau gaagaccauc cagcgcugca acaccggcga gcgcucccuc ucccuccuca      300

acugcgagga gaucaagucc caguucgagg gcuucgucaa ggacaucaug cucaacaagg      360

aggagaccaa gaaggagaac uccuucgaga ugcagaaggg cgaccagaac ccccagaucg      420

ccgcccacgu caucuccgag gccuccucca agaccaccuc cguccuccag ugggccgaga      480

agggcuacua caccaugucc aacaaccucg ucacccucga gaacggcaag cagcucaccg      540

ucaagcgcca gggccucuac uacaucuacg cccaggucac cuucugcucc aaccgcgagg      600

ccuccuccca ggcccccuuc aucgccuccc ucugccucaa gucccccggc cgcuucgagc      660

gcauccuccu ccgcgccgcc aacacccacu ccuccgccaa gcccugcggc cagcagucca      720

uccaccucgg cggcgucuuc gagcuccagc ccggcgccuc cgucuucguc aacgucaccg      780

accccuccca ggucucccac ggcaccggcu ucaccuccuu cggccuccuc aagcucugag      840

gacuagugca ucacauuuaa aagcaucuca gccuaccaug agaauaagag aaagaaaaug      900

aagaucaaua gcuuauucau cucuuuuucu uuuucguugg uguaaagcca acacccuguc      960

uaaaaaacau aaauuucuuu aaucauuuug ccucuuuucu cugugcuuca auuaauaaaa     1020

aauggaaaga accuagaucu aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa     1080

aaaaaaaaaa aaaaaaaaaa aaaaugcauc cccccccccc cccccccccc cccccccccc     1140

aaaggcucuu uucagagcca ccagaauu                                        1168


<210>  309
<211>  1249
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  PDCD1 mRNA product TOP UTR opt3

<400>  309
ggggcgcugc cuacggaggu ggcagccauc uccuucucgg caucaagcuu accaugcaga       60

ucccccaagc cccuuggcca guggucuggg cuguucugca gcucggcugg agaccggggu      120

gguuccuuga cagccccgau aggccuugga acccacccac cuuuuccccu gcacuguugg      180

ugguaacaga gggagacaau gccacuuuca cgugcucuuu uucaaacacc agugagagcu      240

ucguguuaaa uugguaccgg auguccccau cuaaccagac agauaagcug gcggcuuuuc      300

ccgaagaccg cucgcagccu ggucaagauu gucgauuccg ugucacucag cuaccaaaug      360

gcagagacuu ucacauguca gugguuaggg cccggcgcaa cgauagcggg accuaucucu      420

gcggagcaau uagucuggcc ccgaaagcuc agauaaagga aucccuuaga gcagagcuga      480

gggugacaga acggcgcgcc gaggucccca ccgcucaucc uucuccaagc ccccgaccug      540

ccggccaguu ccaaacuuug gugguaggug uugucggggg acuccugggc ucccuggugc      600

ucuuagugug ggugcuggcg gucaucuguu caagagcagc caggggcaca auuggggcuc      660

ggcguaccgg acagccacuu aaagaggacc ccagugccgu uccgguguuu agcguagauu      720

acggugaauu ggacuuccag uggcgcgaga agacgccuga acccccagug ccuugcgucc      780

ccgagcagac ugaguaugca accaucgugu uuccaucugg cauggggaca uccucacccg      840

cuagaagggg aagcgccgau ggcccucgga gugcgcaacc acugcgaccg gaagacgguc      900

acuguucuug gccccuauga ggacuagugc aucacauuua aaagcaucuc agccuaccau      960

gagaauaaga gaaagaaaau gaagaucaau agcuuauuca ucucuuuuuc uuuuucguug     1020

guguaaagcc aacacccugu cuaaaaaaca uaaauuucuu uaaucauuuu gccucuuuuc     1080

ucugugcuuc aauuaauaaa aaauggaaag aaccuagauc uaaaaaaaaa aaaaaaaaaa     1140

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaugcau cccccccccc     1200

cccccccccc cccccccccc caaaggcucu uuucagagcc accagaauu                 1249


<210>  310
<211>  832
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  PDCD1(1-149) mRNA product TOP UTR opt3

<400>  310
ggggcgcugc cuacggaggu ggcagccauc uccuucucgg caucaagcuu accaugcaga       60

ucccccaagc cccuuggcca guggucuggg cuguucugca gcucggcugg agaccggggu      120

gguuccuuga cagccccgau aggccuugga acccacccac cuuuuccccu gcacuguugg      180

ugguaacaga gggagacaau gccacuuuca cgugcucuuu uucaaacacc agugagagcu      240

ucguguuaaa uugguaccgg auguccccau cuaaccagac agauaagcug gcggcuuuuc      300

ccgaagaccg cucgcagccu ggucaagauu gucgauuccg ugucacucag cuaccaaaug      360

gcagagacuu ucacauguca gugguuaggg cccggcgcaa cgauagcggg accuaucucu      420

gcggagcaau uagucuggcc ccgaaagcuc agauaaagga aucccuuaga gcagagcuga      480

gggugacaga acggcgcgcc ugaggacuag ugcaucacau uuaaaagcau cucagccuac      540

caugagaaua agagaaagaa aaugaagauc aauagcuuau ucaucucuuu uucuuuuucg      600

uugguguaaa gccaacaccc ugucuaaaaa acauaaauuu cuuuaaucau uuugccucuu      660

uucucugugc uucaauuaau aaaaaaugga aagaaccuag aucuaaaaaa aaaaaaaaaa      720

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaug cauccccccc      780

cccccccccc cccccccccc ccccaaaggc ucuuuucaga gccaccagaa uu              832


<210>  311
<211>  1042
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  IL12A mRNA product TOP UTR opt3

<400>  311
ggggcgcugc cuacggaggu ggcagccauc uccuucucgg caucaagcuu accaugugcc       60

ccgccagaag ccugcuccuu guggcuaccc uggucuuguu agaccaccug ucccuagcaa      120

ggaaccuccc uguugccaca ccagauccgg gcauguuccc cugucugcau cacucucaga      180

aucuucugcg ggcgguguca aacauguugc aaaaggcucg ccagacucuc gaguuuuacc      240

cuugcacgag ugaagagauc gaccaugaag auauuaccaa agacaagaca agcacuguag      300

aggccugucu gccacuggaa cucaccaaaa augaguccug cuuaaacucu cgagagacau      360

cguucauaac caauggguca ugucuggcaa gccguaagac aaguuuuaug auggcccuuu      420

gcuuguccuc uaucuaugaa gaucugaaaa uguaccaggu ggaguucaag acuaugaacg      480

cuaagcuacu cauggacccc aaaagacaga uuuuucugga ucaaaauaug cuugcaguca      540

ucgacgaacu gaugcaggcc uugaacuuca auagcgagac cgugccucag aaguccucac      600

ucgaggaacc agauuuuuau aaaacgaaga uuaaacugug uaucuuacug cacgcuuuca      660

ggauacgggc cguuacuauc gaccgcguga ugaguuaccu caacgcgagc ugaggacuag      720

ugcaucacau uuaaaagcau cucagccuac caugagaaua agagaaagaa aaugaagauc      780

aauagcuuau ucaucucuuu uucuuuuucg uugguguaaa gccaacaccc ugucuaaaaa      840

acauaaauuu cuuuaaucau uuugccucuu uucucugugc uucaauuaau aaaaaaugga      900

aagaaccuag aucuaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa      960

aaaaaaaaaa aaaaaaaaug cauccccccc cccccccccc cccccccccc ccccaaaggc     1020

ucuuuucaga gccaccagaa uu                                              1042


<210>  312
<211>  1039
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  IL12A(1-219) mRNA product TOP UTR opt3

<400>  312
ggggcgcugc cuacggaggu ggcagccauc uccuucucgg caucaagcuu accaugugcc       60

ccgccagaag ccugcuccuu guggcuaccc uggucuuguu agaccaccug ucccuagcaa      120

ggaaccuccc uguugccaca ccagauccgg gcauguuccc cugucugcau cacucucaga      180

aucuucugcg ggcgguguca aacauguugc aaaaggcucg ccagacucuc gaguuuuacc      240

cuugcacgag ugaagagauc gaccaugaag auauuaccaa agacaagaca agcacuguag      300

aggccugucu gccacuggaa cucaccaaaa augaguccug cuuaaacucu cgagagacau      360

cguucauaac caauggguca ugucuggcaa gccguaagac aaguuuuaug auggcccuuu      420

gcuuguccuc uaucuaugaa gaucugaaaa uguaccaggu ggaguucaag acuaugaacg      480

cuaagcuacu cauggacccc aaaagacaga uuuuucugga ucaaaauaug cuugcaguca      540

ucgacgaacu gaugcaggcc uugaacuuca auagcgagac cgugccucag aaguccucac      600

ucgaggaacc agauuuuuau aaaacgaaga uuaaacugug uaucuuacug cacgcuuuca      660

ggauacgggc cguuacuauc gaccgcguga ugaguuaccu caacgcgagc ggacuagugc      720

aucacauuua aaagcaucuc agccuaccau gagaauaaga gaaagaaaau gaagaucaau      780

agcuuauuca ucucuuuuuc uuuuucguug guguaaagcc aacacccugu cuaaaaaaca      840

uaaauuucuu uaaucauuuu gccucuuuuc ucugugcuuc aauuaauaaa aaauggaaag      900

aaccuagauc uaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa      960

aaaaaaaaaa aaaaaugcau cccccccccc cccccccccc cccccccccc caaaggcucu     1020

uuucagagcc accagaauu                                                  1039


<210>  313
<211>  976
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  IL12A(23-219) mRNA product TOP UTR opt3

<400>  313
ggggcgcugc cuacggaggu ggcagccauc uccuucucgg caucaagcuu accaggaacc       60

ucccuguugc cacaccagau ccgggcaugu uccccugucu gcaucacucu cagaaucuuc      120

ugcgggcggu gucaaacaug uugcaaaagg cucgccagac ucucgaguuu uacccuugca      180

cgagugaaga gaucgaccau gaagauauua ccaaagacaa gacaagcacu guagaggccu      240

gucugccacu ggaacucacc aaaaaugagu ccugcuuaaa cucucgagag acaucguuca      300

uaaccaaugg gucaugucug gcaagccgua agacaaguuu uaugauggcc cuuugcuugu      360

ccucuaucua ugaagaucug aaaauguacc agguggaguu caagacuaug aacgcuaagc      420

uacucaugga ccccaaaaga cagauuuuuc uggaucaaaa uaugcuugca gucaucgacg      480

aacugaugca ggccuugaac uucaauagcg agaccgugcc ucagaagucc ucacucgagg      540

aaccagauuu uuauaaaacg aagauuaaac uguguaucuu acugcacgcu uucaggauac      600

gggccguuac uaucgaccgc gugaugaguu accucaacgc gagcugagga cuagugcauc      660

acauuuaaaa gcaucucagc cuaccaugag aauaagagaa agaaaaugaa gaucaauagc      720

uuauucaucu cuuuuucuuu uucguuggug uaaagccaac acccugucua aaaaacauaa      780

auuucuuuaa ucauuuugcc ucuuuucucu gugcuucaau uaauaaaaaa uggaaagaac      840

cuagaucuaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa      900

aaaaaaaaaa aaugcauccc cccccccccc cccccccccc ccccccccaa aggcucuuuu      960

cagagccacc agaauu                                                      976


<210>  314
<211>  1369
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  IL12B mRNA product TOP UTR opt3

<400>  314
ggggcgcugc cuacggaggu ggcagccauc uccuucucgg caucaagcuu accaugugcc       60

accagcaacu ggugaucagc ugguucuccc ucgucuuucu ugccucuccc cugguugcua      120

uuugggaguu gaagaaagac guguacguag uggaauuaga uugguauccu gacgcaccag      180

gcgagauggu cgugcugacc ugugauacac cggaagagga cgggauaacu uggacgcuag      240

aucagucaag ugaaguucuc ggaagcggua agacccugac aauccaggug aaagaguucg      300

gcgacgccgg gcaguacacu ugccauaagg gaggcgaggu ccuuucccac ucucuguugc      360

uccugcauaa aaaggaagau gguauuuggu cgaccgacau ccugaaggau caaaaagagc      420

ccaagaacaa aacauuucuc agaugugaag cgaagaauua uucagggagg uuuaccugcu      480

ggugguuaac uacaauuagc accgaccuga cguucagugu gaaauccucu cggggaagcu      540

ccgauccuca gggcguaacu uguggcgcug ccacccuuuc agcagagcgc guucgagggg      600

acaacaagga guacgaauau aguguggagu gccaggaaga uagcgccugu ccagcugcag      660

aggaaucuuu gcccaucgag gucauggugg acgccgugca caagcugaaa uacgagaauu      720

auacauccuc auucuuuaua cgugacauca uuaagccuga uccacccaaa aaccuacagc      780

ucaagccucu gaaaaauagc agacaagucg aaguuaguug ggaguaccca gacacuuggu      840

cuaccccgca uuccuacuuc agccuuacau uuugcgugca gguacaggga aagucgaaaa      900

gggaaaagaa ggaucgggug uucaccgaca aaacgucugc uacugucauc ugucgcaaga      960

acgccuccau uucagugaga gcgcaggaua gguauuacag uagcuccugg ucugaguggg     1020

caagcguucc cugcucauga ggacuagugc aucacauuua aaagcaucuc agccuaccau     1080

gagaauaaga gaaagaaaau gaagaucaau agcuuauuca ucucuuuuuc uuuuucguug     1140

guguaaagcc aacacccugu cuaaaaaaca uaaauuucuu uaaucauuuu gccucuuuuc     1200

ucugugcuuc aauuaauaaa aaauggaaag aaccuagauc uaaaaaaaaa aaaaaaaaaa     1260

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaugcau cccccccccc     1320

cccccccccc cccccccccc caaaggcucu uuucagagcc accagaauu                 1369


<210>  315
<211>  1366
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  IL12B(1-328) mRNA product TOP UTR opt3

<400>  315
ggggcgcugc cuacggaggu ggcagccauc uccuucucgg caucaagcuu accaugugcc       60

accagcaacu ggugaucagc ugguucuccc ucgucuuucu ugccucuccc cugguugcua      120

uuugggaguu gaagaaagac guguacguag uggaauuaga uugguauccu gacgcaccag      180

gcgagauggu cgugcugacc ugugauacac cggaagagga cgggauaacu uggacgcuag      240

aucagucaag ugaaguucuc ggaagcggua agacccugac aauccaggug aaagaguucg      300

gcgacgccgg gcaguacacu ugccauaagg gaggcgaggu ccuuucccac ucucuguugc      360

uccugcauaa aaaggaagau gguauuuggu cgaccgacau ccugaaggau caaaaagagc      420

ccaagaacaa aacauuucuc agaugugaag cgaagaauua uucagggagg uuuaccugcu      480

ggugguuaac uacaauuagc accgaccuga cguucagugu gaaauccucu cggggaagcu      540

ccgauccuca gggcguaacu uguggcgcug ccacccuuuc agcagagcgc guucgagggg      600

acaacaagga guacgaauau aguguggagu gccaggaaga uagcgccugu ccagcugcag      660

aggaaucuuu gcccaucgag gucauggugg acgccgugca caagcugaaa uacgagaauu      720

auacauccuc auucuuuaua cgugacauca uuaagccuga uccacccaaa aaccuacagc      780

ucaagccucu gaaaaauagc agacaagucg aaguuaguug ggaguaccca gacacuuggu      840

cuaccccgca uuccuacuuc agccuuacau uuugcgugca gguacaggga aagucgaaaa      900

gggaaaagaa ggaucgggug uucaccgaca aaacgucugc uacugucauc ugucgcaaga      960

acgccuccau uucagugaga gcgcaggaua gguauuacag uagcuccugg ucugaguggg     1020

caagcguucc cugcucagga cuagugcauc acauuuaaaa gcaucucagc cuaccaugag     1080

aauaagagaa agaaaaugaa gaucaauagc uuauucaucu cuuuuucuuu uucguuggug     1140

uaaagccaac acccugucua aaaaacauaa auuucuuuaa ucauuuugcc ucuuuucucu     1200

gugcuucaau uaauaaaaaa uggaaagaac cuagaucuaa aaaaaaaaaa aaaaaaaaaa     1260

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaugcauccc cccccccccc     1320

cccccccccc ccccccccaa aggcucuuuu cagagccacc agaauu                    1366


<210>  316
<211>  1303
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  IL12B(23-328) mRNA product TOP UTR opt3

<400>  316
ggggcgcugc cuacggaggu ggcagccauc uccuucucgg caucaagcuu accauuuggg       60

aguugaagaa agacguguac guaguggaau uagauuggua uccugacgca ccaggcgaga      120

uggucgugcu gaccugugau acaccggaag aggacgggau aacuuggacg cuagaucagu      180

caagugaagu ucucggaagc gguaagaccc ugacaaucca ggugaaagag uucggcgacg      240

ccgggcagua cacuugccau aagggaggcg agguccuuuc ccacucucug uugcuccugc      300

auaaaaagga agaugguauu uggucgaccg acauccugaa ggaucaaaaa gagcccaaga      360

acaaaacauu ucucagaugu gaagcgaaga auuauucagg gagguuuacc ugcugguggu      420

uaacuacaau uagcaccgac cugacguuca gugugaaauc cucucgggga agcuccgauc      480

cucagggcgu aacuuguggc gcugccaccc uuucagcaga gcgcguucga ggggacaaca      540

aggaguacga auauagugug gagugccagg aagauagcgc cuguccagcu gcagaggaau      600

cuuugcccau cgaggucaug guggacgccg ugcacaagcu gaaauacgag aauuauacau      660

ccucauucuu uauacgugac aucauuaagc cugauccacc caaaaaccua cagcucaagc      720

cucugaaaaa uagcagacaa gucgaaguua guugggagua cccagacacu uggucuaccc      780

cgcauuccua cuucagccuu acauuuugcg ugcagguaca gggaaagucg aaaagggaaa      840

agaaggaucg gguguucacc gacaaaacgu cugcuacugu caucugucgc aagaacgccu      900

ccauuucagu gagagcgcag gauagguauu acaguagcuc cuggucugag ugggcaagcg      960

uucccugcuc augaggacua gugcaucaca uuuaaaagca ucucagccua ccaugagaau     1020

aagagaaaga aaaugaagau caauagcuua uucaucucuu uuucuuuuuc guugguguaa     1080

agccaacacc cugucuaaaa aacauaaauu ucuuuaauca uuuugccucu uuucucugug     1140

cuucaauuaa uaaaaaaugg aaagaaccua gaucuaaaaa aaaaaaaaaa aaaaaaaaaa     1200

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaau gcaucccccc cccccccccc     1260

cccccccccc cccccaaagg cucuuuucag agccaccaga auu                       1303


<210>  317
<211>  436
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Linker-sFvCC49-218 mRNA product TOP UTR opt3

<400>  317
ggggcgcugc cuacggaggu ggcagccauc uccuucucgg caucaagcuu accggcagca       60

ccuccggguc uggaaagccc gguucaggcg aggggaguac aaaaggagga cuagugcauc      120

acauuuaaaa gcaucucagc cuaccaugag aauaagagaa agaaaaugaa gaucaauagc      180

uuauucaucu cuuuuucuuu uucguuggug uaaagccaac acccugucua aaaaacauaa      240

auuucuuuaa ucauuuugcc ucuuuucucu gugcuucaau uaauaaaaaa uggaaagaac      300

cuagaucuaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa      360

aaaaaaaaaa aaugcauccc cccccccccc cccccccccc ccccccccaa aggcucuuuu      420

cagagccacc agaauu                                                      436


<210>  318
<211>  2014
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  IL12 mRNA product TOP UTR opt3

<400>  318
ggggcgcugc cuacggaggu ggcagccauc uccuucucgg caucaagcuu accaugugcc       60

accagcaacu ggugaucagc ugguucuccc ucgucuuucu ugccucuccc cugguugcua      120

uuugggaguu gaagaaagac guguacguag uggaauuaga uugguauccu gacgcaccag      180

gcgagauggu cgugcugacc ugugauacac cggaagagga cgggauaacu uggacgcuag      240

aucagucaag ugaaguucuc ggaagcggua agacccugac aauccaggug aaagaguucg      300

gcgacgccgg gcaguacacu ugccauaagg gaggcgaggu ccuuucccac ucucuguugc      360

uccugcauaa aaaggaagau gguauuuggu cgaccgacau ccugaaggau caaaaagagc      420

ccaagaacaa aacauuucuc agaugugaag cgaagaauua uucagggagg uuuaccugcu      480

ggugguuaac uacaauuagc accgaccuga cguucagugu gaaauccucu cggggaagcu      540

ccgauccuca gggcguaacu uguggcgcug ccacccuuuc agcagagcgc guucgagggg      600

acaacaagga guacgaauau aguguggagu gccaggaaga uagcgccugu ccagcugcag      660

aggaaucuuu gcccaucgag gucauggugg acgccgugca caagcugaaa uacgagaauu      720

auacauccuc auucuuuaua cgugacauca uuaagccuga uccacccaaa aaccuacagc      780

ucaagccucu gaaaaauagc agacaagucg aaguuaguug ggaguaccca gacacuuggu      840

cuaccccgca uuccuacuuc agccuuacau uuugcgugca gguacaggga aagucgaaaa      900

gggaaaagaa ggaucgggug uucaccgaca aaacgucugc uacugucauc ugucgcaaga      960

acgccuccau uucagugaga gcgcaggaua gguauuacag uagcuccugg ucugaguggg     1020

caagcguucc cugcucaggc agcaccuccg ggucuggaaa gcccgguuca ggcgagggga     1080

guacaaaagg aaggaaccuc ccuguugcca caccagaucc gggcauguuc cccugucugc     1140

aucacucuca gaaucuucug cgggcggugu caaacauguu gcaaaaggcu cgccagacuc     1200

ucgaguuuua cccuugcacg agugaagaga ucgaccauga agauauuacc aaagacaaga     1260

caagcacugu agaggccugu cugccacugg aacucaccaa aaaugagucc ugcuuaaacu     1320

cucgagagac aucguucaua accaaugggu caugucuggc aagccguaag acaaguuuua     1380

ugauggcccu uugcuugucc ucuaucuaug aagaucugaa aauguaccag guggaguuca     1440

agacuaugaa cgcuaagcua cucauggacc ccaaaagaca gauuuuucug gaucaaaaua     1500

ugcuugcagu caucgacgaa cugaugcagg ccuugaacuu caauagcgag accgugccuc     1560

agaaguccuc acucgaggaa ccagauuuuu auaaaacgaa gauuaaacug uguaucuuac     1620

ugcacgcuuu caggauacgg gccguuacua ucgaccgcgu gaugaguuac cucaacgcga     1680

gcugaggacu agugcaucac auuuaaaagc aucucagccu accaugagaa uaagagaaag     1740

aaaaugaaga ucaauagcuu auucaucucu uuuucuuuuu cguuggugua aagccaacac     1800

ccugucuaaa aaacauaaau uucuuuaauc auuuugccuc uuuucucugu gcuucaauua     1860

auaaaaaaug gaaagaaccu agaucuaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa     1920

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa ugcauccccc cccccccccc cccccccccc     1980

ccccccaaag gcucuuuuca gagccaccag aauu                                 2014


<210>  319
<211>  1168
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  CD40LG mRNA product TOP UTR opt3

<400>  319
ggggcgcugc cuacggaggu ggcagccauc uccuucucgg caucaagcuu accaugaucg       60

agaccuacaa ccagacaagc cccagauccg ccgcuacugg ccugccuauu ucuaugaaga      120

uauucaugua ucuccuuacg guguuucuga ucacccaaau gauuggguca gcauuguucg      180

ccgucuacuu acacaggcgg cuggacaaaa ucgaagauga gcgcaaucua caugaagacu      240

uuguuuucau gaagacaauu cagcgaugca acacuggaga gcguagucuc agccugcuua      300

auugugaaga gaucaaaucc caguuugagg guuucgugaa ggauauaaug cugaacaaag      360

aagagaccaa gaaggaaaau ucuuuugaga ugcagaaagg cgaccaaaac ccacagaucg      420

cggcucacgu aauuucggag gccucaagca agacaaccag uguguugcag ugggcagaaa      480

aaggguauua cacuaugucc aauaaccucg ucacacugga gaauggaaag cagcugaccg      540

ugaaaagaca aggccucuau uacaucuaug cccagguuac guucugcucu aacagggaag      600

cuagcuccca ggcaccguuu auugccucau uaugucugaa gagucccggu cgguucgagc      660

gcauccuuuu gagagcugcc aauacucaua gcucugcgaa gccuugcggg cagcaaucca      720

uacaccuggg aggcguguuu gaacuacagc caggcgcauc agucuucgug aacguaaccg      780

aucccagcca gguuagucau gggacaggau uuacuucuuu cggucuccug aaacuuugag      840

gacuagugca ucacauuuaa aagcaucuca gccuaccaug agaauaagag aaagaaaaug      900

aagaucaaua gcuuauucau cucuuuuucu uuuucguugg uguaaagcca acacccuguc      960

uaaaaaacau aaauuucuuu aaucauuuug ccucuuuucu cugugcuuca auuaauaaaa     1020

aauggaaaga accuagaucu aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa     1080

aaaaaaaaaa aaaaaaaaaa aaaaugcauc cccccccccc cccccccccc cccccccccc     1140

aaaggcucuu uucagagcca ccagaauu                                        1168


<210>  320
<211>  1249
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  PDCD1 mRNA product TOP UTR opt3v

<400>  320
ggggcgcugc cuacggaggu ggcagccauc uccuucucgg caucaagcuu accaugcaga       60

ucccucaggc uccuuggccu guuguguggg cuguucugca acuuggaugg cggccuggcu      120

gguuccugga cucuccugac agacccugga auccuccaac auucagcccc gcucugcugg      180

ugguuaccga gggcgauaau gccaccuuca ccuguagcuu cagcaacacc agcgagagcu      240

ucgugcugaa cugguacaga augagcccca gcaaccagac cgacaagcug gccgccuuuc      300

cugaggauag aucucagccc ggccaggacu gccgguucag aguuacacag cugcccaacg      360

gccgggacuu ccacaugucu gucguccggg ccagaagaaa cgacagcggc acauaucugu      420

gcggcgccau uucucuggcc ccuaaggcuc agaucaaaga gagccugaga gccgagcuga      480

gagugacaga aagacgggcc gaagugccca cagcucaccc uucaccuucu ccaagaccug      540

ccggccaguu ccagacacug gucgugggag uuguuggcgg acugcuggga ucucuggugc      600

ugcuuguuug ggugcucgcc gugaucugua gcagagccgc cagaggaaca aucggcgcca      660

gaaggacagg ccagccucug aaagaggauc ccucugcugu ccccguguuc agcguggacu      720

auggcgagcu ggauuuccag uggcgggaaa agacacccga gccuccagug ccuugugugc      780

cugagcagac agaguacgcc accaucgugu ucccuagcgg caugggcaca ucuagcccug      840

ccagaagagg aucugccgac ggaccuagau cugcccagcc ucucagaccu gaggauggcc      900

acuguagcug gccucuguaa ggacuagugc aucacauuua aaagcaucuc agccuaccau      960

gagaauaaga gaaagaaaau gaagaucaau agcuuauuca ucucuuuuuc uuuuucguug     1020

guguaaagcc aacacccugu cuaaaaaaca uaaauuucuu uaaucauuuu gccucuuuuc     1080

ucugugcuuc aauuaauaaa aaauggaaag aaccuagauc uaaaaaaaaa aaaaaaaaaa     1140

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaugcau cccccccccc     1200

cccccccccc cccccccccc caaaggcucu uuucagagcc accagaauu                 1249


<210>  321
<211>  832
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  PDCD1(1-149) mRNA product TOP UTR opt3v

<400>  321
ggggcgcugc cuacggaggu ggcagccauc uccuucucgg caucaagcuu accaugcaga       60

ucccucaggc uccuuggccu guuguguggg cuguucugca acuuggaugg cggccuggcu      120

gguuccugga cucuccugac agacccugga auccuccaac auucagcccc gcucugcugg      180

ugguuaccga gggcgauaau gccaccuuca ccuguagcuu cagcaacacc agcgagagcu      240

ucgugcugaa cugguacaga augagcccca gcaaccagac cgacaagcug gccgccuuuc      300

cugaggauag aucucagccc ggccaggacu gccgguucag aguuacacag cugcccaacg      360

gccgggacuu ccacaugucu gucguccggg ccagaagaaa cgacagcggc acauaucugu      420

gcggcgccau uucucuggcc ccuaaggcuc agaucaaaga gagccugaga gccgagcuga      480

gagugacaga aagacgggcc ugaggacuag ugcaucacau uuaaaagcau cucagccuac      540

caugagaaua agagaaagaa aaugaagauc aauagcuuau ucaucucuuu uucuuuuucg      600

uugguguaaa gccaacaccc ugucuaaaaa acauaaauuu cuuuaaucau uuugccucuu      660

uucucugugc uucaauuaau aaaaaaugga aagaaccuag aucuaaaaaa aaaaaaaaaa      720

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaug cauccccccc      780

cccccccccc cccccccccc ccccaaaggc ucuuuucaga gccaccagaa uu              832


<210>  322
<211>  1042
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  IL12A mRNA product TOP UTR opt3v

<400>  322
ggggcgcugc cuacggaggu ggcagccauc uccuucucgg caucaagcuu accaugugcc       60

cugccagauc ucugcugcug guggcuacac uggugcugcu ggaucaucug agccuggcca      120

gaaaccugcc aguggccacg ccugauccug gcauguuucc uugucugcac cacagccaga      180

accugcugag agccgugucc aacaugcugc agaaggccag acagacccuc gaguucuacc      240

ccugcaccag cgaggaaauc gaccacgagg acaucaccaa ggacaagacc agcaccgugg      300

aagccugccu gccucuggaa cugaccaaga acgagagcug ccugaacagc cgggaaacca      360

gcuucaucac caacggcucu ugccuggccu ccagaaagac cuccuucaug auggcccugu      420

gccugagcag caucuacgag gaccugaaga uguaccaggu cgaguucaag accaugaacg      480

ccaagcugcu gauggacccc aagcggcaga ucuuccugga ccagaauaug cuggccguga      540

ucgacgagcu gaugcaggcc cugaacuuca acagcgagac agugccccag aaguccagcc      600

uggaagaacc cgacuucuac aagaccaaga ucaagcugug cauccugcug cacgccuucc      660

ggaucagagc cgugaccauc gacagaguga ugagcuaccu gaacgccucc ugaggacuag      720

ugcaucacau uuaaaagcau cucagccuac caugagaaua agagaaagaa aaugaagauc      780

aauagcuuau ucaucucuuu uucuuuuucg uugguguaaa gccaacaccc ugucuaaaaa      840

acauaaauuu cuuuaaucau uuugccucuu uucucugugc uucaauuaau aaaaaaugga      900

aagaaccuag aucuaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa      960

aaaaaaaaaa aaaaaaaaug cauccccccc cccccccccc cccccccccc ccccaaaggc     1020

ucuuuucaga gccaccagaa uu                                              1042


<210>  323
<211>  1039
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  IL12A(1-219) mRNA product TOP UTR opt3v

<400>  323
ggggcgcugc cuacggaggu ggcagccauc uccuucucgg caucaagcuu accaugugcc       60

cugccagauc ucugcugcug guggcuacac uggugcugcu ggaucaucug agccuggcca      120

gaaaccugcc aguggccacg ccugauccug gcauguuucc uugucugcac cacagccaga      180

accugcugag agccgugucc aacaugcugc agaaggccag acagacccuc gaguucuacc      240

ccugcaccag cgaggaaauc gaccacgagg acaucaccaa ggacaagacc agcaccgugg      300

aagccugccu gccucuggaa cugaccaaga acgagagcug ccugaacagc cgggaaacca      360

gcuucaucac caacggcucu ugccuggccu ccagaaagac cuccuucaug auggcccugu      420

gccugagcag caucuacgag gaccugaaga uguaccaggu cgaguucaag accaugaacg      480

ccaagcugcu gauggacccc aagcggcaga ucuuccugga ccagaauaug cuggccguga      540

ucgacgagcu gaugcaggcc cugaacuuca acagcgagac agugccccag aaguccagcc      600

uggaagaacc cgacuucuac aagaccaaga ucaagcugug cauccugcug cacgccuucc      660

ggaucagagc cgugaccauc gacagaguga ugagcuaccu gaacgccucc ggacuagugc      720

aucacauuua aaagcaucuc agccuaccau gagaauaaga gaaagaaaau gaagaucaau      780

agcuuauuca ucucuuuuuc uuuuucguug guguaaagcc aacacccugu cuaaaaaaca      840

uaaauuucuu uaaucauuuu gccucuuuuc ucugugcuuc aauuaauaaa aaauggaaag      900

aaccuagauc uaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa      960

aaaaaaaaaa aaaaaugcau cccccccccc cccccccccc cccccccccc caaaggcucu     1020

uuucagagcc accagaauu                                                  1039


<210>  324
<211>  976
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  IL12A(23-219) mRNA product TOP UTR opt3v

<400>  324
ggggcgcugc cuacggaggu ggcagccauc uccuucucgg caucaagcuu accagaaacc       60

ugccaguggc cacgccugau ccuggcaugu uuccuugucu gcaccacagc cagaaccugc      120

ugagagccgu guccaacaug cugcagaagg ccagacagac ccucgaguuc uaccccugca      180

ccagcgagga aaucgaccac gaggacauca ccaaggacaa gaccagcacc guggaagccu      240

gccugccucu ggaacugacc aagaacgaga gcugccugaa cagccgggaa accagcuuca      300

ucaccaacgg cucuugccug gccuccagaa agaccuccuu caugauggcc cugugccuga      360

gcagcaucua cgaggaccug aagauguacc aggucgaguu caagaccaug aacgccaagc      420

ugcugaugga ccccaagcgg cagaucuucc uggaccagaa uaugcuggcc gugaucgacg      480

agcugaugca ggcccugaac uucaacagcg agacagugcc ccagaagucc agccuggaag      540

aacccgacuu cuacaagacc aagaucaagc ugugcauccu gcugcacgcc uuccggauca      600

gagccgugac caucgacaga gugaugagcu accugaacgc cuccugagga cuagugcauc      660

acauuuaaaa gcaucucagc cuaccaugag aauaagagaa agaaaaugaa gaucaauagc      720

uuauucaucu cuuuuucuuu uucguuggug uaaagccaac acccugucua aaaaacauaa      780

auuucuuuaa ucauuuugcc ucuuuucucu gugcuucaau uaauaaaaaa uggaaagaac      840

cuagaucuaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa      900

aaaaaaaaaa aaugcauccc cccccccccc cccccccccc ccccccccaa aggcucuuuu      960

cagagccacc agaauu                                                      976


<210>  325
<211>  1369
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  IL12B mRNA product TOP UTR opt3v

<400>  325
ggggcgcugc cuacggaggu ggcagccauc uccuucucgg caucaagcuu accauguguc       60

accagcagcu ggucaucagc ugguucagcc ugguguuccu ggccucuccu cugguggcca      120

ucugggagcu gaagaaagac guguacgugg uggaacugga cugguauccc gaugcuccug      180

gcgagauggu ggugcugacc ugcgauaccc cugaagagga cggcaucacc uggacacugg      240

aucagucuag cgaggugcuc ggcagcggca agacccugac cauccaagug aaagaguuug      300

gcgacgccgg ccaguacacc ugucacaaag gcggagaagu gcugagccac agccugcugc      360

ugcuccacaa gaaagaggau ggcauuugga gcaccgacau ccugaaggac cagaaagagc      420

ccaagaacaa gaccuuccug agaugcgagg ccaagaacua cagcggccgg uucacauguu      480

gguggcugac caccaucagc accgaccuga ccuucagcgu gaaguccagc agaggcagca      540

gugauccuca gggcguuaca uguggcgccg cuacacuguc ugccgaaaga gugcggggcg      600

acaacaaaga auacgaguac agcguggaau gccaagagga cagcgccugu ccagccgccg      660

aagagucucu gccuaucgaa gugauggugg acgccgugca caagcugaag uacgagaacu      720

acaccuccag cuuuuucauc cgggacauca ucaagcccga uccuccaaag aaccugcagc      780

ugaagccucu gaagaacagc agacaggugg aaguguccug ggaguacccc gacaccuggu      840

cuacacccca cagcuacuuc agccugaccu uuugcgugca agugcagggc aaguccaagc      900

gcgagaaaaa ggaccgggug uucaccgaca agaccagcgc caccgugauc ugcagaaaga      960

acgccagcau cagcgucaga gcccaggacc gguacuacag cagcucuugg agcgaauggg     1020

ccagcgugcc auguagcuaa ggacuagugc aucacauuua aaagcaucuc agccuaccau     1080

gagaauaaga gaaagaaaau gaagaucaau agcuuauuca ucucuuuuuc uuuuucguug     1140

guguaaagcc aacacccugu cuaaaaaaca uaaauuucuu uaaucauuuu gccucuuuuc     1200

ucugugcuuc aauuaauaaa aaauggaaag aaccuagauc uaaaaaaaaa aaaaaaaaaa     1260

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaugcau cccccccccc     1320

cccccccccc cccccccccc caaaggcucu uuucagagcc accagaauu                 1369


<210>  326
<211>  1366
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  IL12B(1-328) mRNA product TOP UTR opt3v

<400>  326
ggggcgcugc cuacggaggu ggcagccauc uccuucucgg caucaagcuu accauguguc       60

accagcagcu ggucaucagc ugguucagcc ugguguuccu ggccucuccu cugguggcca      120

ucugggagcu gaagaaagac guguacgugg uggaacugga cugguauccc gaugcuccug      180

gcgagauggu ggugcugacc ugcgauaccc cugaagagga cggcaucacc uggacacugg      240

aucagucuag cgaggugcuc ggcagcggca agacccugac cauccaagug aaagaguuug      300

gcgacgccgg ccaguacacc ugucacaaag gcggagaagu gcugagccac agccugcugc      360

ugcuccacaa gaaagaggau ggcauuugga gcaccgacau ccugaaggac cagaaagagc      420

ccaagaacaa gaccuuccug agaugcgagg ccaagaacua cagcggccgg uucacauguu      480

gguggcugac caccaucagc accgaccuga ccuucagcgu gaaguccagc agaggcagca      540

gugauccuca gggcguuaca uguggcgccg cuacacuguc ugccgaaaga gugcggggcg      600

acaacaaaga auacgaguac agcguggaau gccaagagga cagcgccugu ccagccgccg      660

aagagucucu gccuaucgaa gugauggugg acgccgugca caagcugaag uacgagaacu      720

acaccuccag cuuuuucauc cgggacauca ucaagcccga uccuccaaag aaccugcagc      780

ugaagccucu gaagaacagc agacaggugg aaguguccug ggaguacccc gacaccuggu      840

cuacacccca cagcuacuuc agccugaccu uuugcgugca agugcagggc aaguccaagc      900

gcgagaaaaa ggaccgggug uucaccgaca agaccagcgc caccgugauc ugcagaaaga      960

acgccagcau cagcgucaga gcccaggacc gguacuacag cagcucuugg agcgaauggg     1020

ccagcgugcc auguagcgga cuagugcauc acauuuaaaa gcaucucagc cuaccaugag     1080

aauaagagaa agaaaaugaa gaucaauagc uuauucaucu cuuuuucuuu uucguuggug     1140

uaaagccaac acccugucua aaaaacauaa auuucuuuaa ucauuuugcc ucuuuucucu     1200

gugcuucaau uaauaaaaaa uggaaagaac cuagaucuaa aaaaaaaaaa aaaaaaaaaa     1260

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaugcauccc cccccccccc     1320

cccccccccc ccccccccaa aggcucuuuu cagagccacc agaauu                    1366


<210>  327
<211>  1303
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  IL12B(23-328) mRNA product TOP UTR opt3v

<400>  327
ggggcgcugc cuacggaggu ggcagccauc uccuucucgg caucaagcuu accaucuggg       60

agcugaagaa agacguguac gugguggaac uggacuggua ucccgaugcu ccuggcgaga      120

ugguggugcu gaccugcgau accccugaag aggacggcau caccuggaca cuggaucagu      180

cuagcgaggu gcucggcagc ggcaagaccc ugaccaucca agugaaagag uuuggcgacg      240

ccggccagua caccugucac aaaggcggag aagugcugag ccacagccug cugcugcucc      300

acaagaaaga ggauggcauu uggagcaccg acauccugaa ggaccagaaa gagcccaaga      360

acaagaccuu ccugagaugc gaggccaaga acuacagcgg ccgguucaca uguugguggc      420

ugaccaccau cagcaccgac cugaccuuca gcgugaaguc cagcagaggc agcagugauc      480

cucagggcgu uacauguggc gccgcuacac ugucugccga aagagugcgg ggcgacaaca      540

aagaauacga guacagcgug gaaugccaag aggacagcgc cuguccagcc gccgaagagu      600

cucugccuau cgaagugaug guggacgccg ugcacaagcu gaaguacgag aacuacaccu      660

ccagcuuuuu cauccgggac aucaucaagc ccgauccucc aaagaaccug cagcugaagc      720

cucugaagaa cagcagacag guggaagugu ccugggagua ccccgacacc uggucuacac      780

cccacagcua cuucagccug accuuuugcg ugcaagugca gggcaagucc aagcgcgaga      840

aaaaggaccg gguguucacc gacaagacca gcgccaccgu gaucugcaga aagaacgcca      900

gcaucagcgu cagagcccag gaccgguacu acagcagcuc uuggagcgaa ugggccagcg      960

ugccauguag cuaaggacua gugcaucaca uuuaaaagca ucucagccua ccaugagaau     1020

aagagaaaga aaaugaagau caauagcuua uucaucucuu uuucuuuuuc guugguguaa     1080

agccaacacc cugucuaaaa aacauaaauu ucuuuaauca uuuugccucu uuucucugug     1140

cuucaauuaa uaaaaaaugg aaagaaccua gaucuaaaaa aaaaaaaaaa aaaaaaaaaa     1200

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaau gcaucccccc cccccccccc     1260

cccccccccc cccccaaagg cucuuuucag agccaccaga auu                       1303


<210>  328
<211>  436
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Linker-sFvCC49-218 mRNA product TOP UTR opt3v

<400>  328
ggggcgcugc cuacggaggu ggcagccauc uccuucucgg caucaagcuu accggcucua       60

caucuggcuc uggcaaaccu ggaucuggcg agggcucuac aaagggcgga cuagugcauc      120

acauuuaaaa gcaucucagc cuaccaugag aauaagagaa agaaaaugaa gaucaauagc      180

uuauucaucu cuuuuucuuu uucguuggug uaaagccaac acccugucua aaaaacauaa      240

auuucuuuaa ucauuuugcc ucuuuucucu gugcuucaau uaauaaaaaa uggaaagaac      300

cuagaucuaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa      360

aaaaaaaaaa aaugcauccc cccccccccc cccccccccc ccccccccaa aggcucuuuu      420

cagagccacc agaauu                                                      436


<210>  329
<211>  2014
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  IL12 mRNA product TOP UTR opt3v

<400>  329
ggggcgcugc cuacggaggu ggcagccauc uccuucucgg caucaagcuu accauguguc       60

accagcagcu ggucaucagc ugguucagcc ugguguuccu ggccucuccu cugguggcca      120

ucugggagcu gaagaaagac guguacgugg uggaacugga cugguauccc gaugcuccug      180

gcgagauggu ggugcugacc ugcgauaccc cugaagagga cggcaucacc uggacacugg      240

aucagucuag cgaggugcuc ggcagcggca agacccugac cauccaagug aaagaguuug      300

gcgacgccgg ccaguacacc ugucacaaag gcggagaagu gcugagccac agccugcugc      360

ugcuccacaa gaaagaggau ggcauuugga gcaccgacau ccugaaggac cagaaagagc      420

ccaagaacaa gaccuuccug agaugcgagg ccaagaacua cagcggccgg uucacauguu      480

gguggcugac caccaucagc accgaccuga ccuucagcgu gaaguccagc agaggcagca      540

gugauccuca gggcguuaca uguggcgccg cuacacuguc ugccgaaaga gugcggggcg      600

acaacaaaga auacgaguac agcguggaau gccaagagga cagcgccugu ccagccgccg      660

aagagucucu gccuaucgaa gugauggugg acgccgugca caagcugaag uacgagaacu      720

acaccuccag cuuuuucauc cgggacauca ucaagcccga uccuccaaag aaccugcagc      780

ugaagccucu gaagaacagc agacaggugg aaguguccug ggaguacccc gacaccuggu      840

cuacacccca cagcuacuuc agccugaccu uuugcgugca agugcagggc aaguccaagc      900

gcgagaaaaa ggaccgggug uucaccgaca agaccagcgc caccgugauc ugcagaaaga      960

acgccagcau cagcgucaga gcccaggacc gguacuacag cagcucuugg agcgaauggg     1020

ccagcgugcc auguagcggc ucuacaucug gcucuggcaa accuggaucu ggcgagggcu     1080

cuacaaaggg cagaaaccug ccaguggcca cgccugaucc uggcauguuu ccuugucugc     1140

accacagcca gaaccugcug agagccgugu ccaacaugcu gcagaaggcc agacagaccc     1200

ucgaguucua ccccugcacc agcgaggaaa ucgaccacga ggacaucacc aaggacaaga     1260

ccagcaccgu ggaagccugc cugccucugg aacugaccaa gaacgagagc ugccugaaca     1320

gccgggaaac cagcuucauc accaacggcu cuugccuggc cuccagaaag accuccuuca     1380

ugauggcccu gugccugagc agcaucuacg aggaccugaa gauguaccag gucgaguuca     1440

agaccaugaa cgccaagcug cugauggacc ccaagcggca gaucuuccug gaccagaaua     1500

ugcuggccgu gaucgacgag cugaugcagg cccugaacuu caacagcgag acagugcccc     1560

agaaguccag ccuggaagaa cccgacuucu acaagaccaa gaucaagcug ugcauccugc     1620

ugcacgccuu ccggaucaga gccgugacca ucgacagagu gaugagcuac cugaacgccu     1680

ccugaggacu agugcaucac auuuaaaagc aucucagccu accaugagaa uaagagaaag     1740

aaaaugaaga ucaauagcuu auucaucucu uuuucuuuuu cguuggugua aagccaacac     1800

ccugucuaaa aaacauaaau uucuuuaauc auuuugccuc uuuucucugu gcuucaauua     1860

auaaaaaaug gaaagaaccu agaucuaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa     1920

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa ugcauccccc cccccccccc cccccccccc     1980

ccccccaaag gcucuuuuca gagccaccag aauu                                 2014


<210>  330
<211>  1168
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  CD40LG mRNA product TOP UTR opt3v

<400>  330
ggggcgcugc cuacggaggu ggcagccauc uccuucucgg caucaagcuu accaugaucg       60

agacauacaa ccagacaagc cccagaagcg ccgccacagg acugccuauc agcaugaaga      120

ucuuuaugua ccugcugacc guguuccuga ucacccagau gaucggcagc gcccuguuug      180

ccguguaccu gcacagacgg cuggacaaga ucgaggacga gagaaaccug cacgaggacu      240

ucguguucau gaagaccauc cagcggugca acaccggcga gagaagucug agccugcuga      300

acugcgagga aaucaagagc caguucgagg gcuucgugaa ggacaucaug cugaacaaag      360

aggaaacgaa gaaagaaaac uccuucgaga ugcagaaggg cgaccagaau ccucagaucg      420

ccgcucacgu gaucagcgag gccagcagca agacaacaag cgugcugcag ugggccgaga      480

agggcuacua caccaugagc aacaaccugg ucacccugga aaacggcaag cagcugacag      540

ugaagcggca gggccuguac uacaucuacg cccaagugac cuucugcagc aacagagagg      600

ccagcucuca ggccccuuuu aucgccagcc ugugccugaa guccccuggc agauucgagc      660

ggauucugcu gagagccgcc aacacacaca gcagcgccaa accuuguggc cagcagucua      720

uucaccucgg cggaguguuu gagcugcagc cuggcgcaag cguguucgug aaugugacag      780

acccuagcca ggugucccac ggcaccggcu uuacaucuuu cggacugcug aagcugugag      840

gacuagugca ucacauuuaa aagcaucuca gccuaccaug agaauaagag aaagaaaaug      900

aagaucaaua gcuuauucau cucuuuuucu uuuucguugg uguaaagcca acacccuguc      960

uaaaaaacau aaauuucuuu aaucauuuug ccucuuuucu cugugcuuca auuaauaaaa     1020

aauggaaaga accuagaucu aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa     1080

aaaaaaaaaa aaaaaaaaaa aaaaugcauc cccccccccc cccccccccc cccccccccc     1140

aaaggcucuu uucagagcca ccagaauu                                        1168


<210>  331
<211>  1249
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  PDCD1 mRNA product TOP UTR opt4

<400>  331
ggggcgcugc cuacggaggu ggcagccauc uccuucucgg caucaagcuu accaugcaga       60

ucccccaggc ccccuggccc gugguguggg ccgugcugca gcugggcugg agacccggcu      120

gguuccugga cagccccgac agacccugga acccccccac cuucagcccc gcccugcugg      180

uggugaccga gggcgacaac gccaccuuca ccuguagcuu cagcaacacc agcgagagcu      240

ucgugcugaa cugguacaga augagcccca gcaaccagac cgacaagcug gccgccuucc      300

ccgaggacag aagccagccc ggccaggacu gcagauucag agugacccag cugcccaacg      360

gcagagacuu ccacaugagc guggugagag ccagaagaaa cgacagcggc accuaccugu      420

gcggcgccau cagccuggcc cccaaggccc agaucaagga gagccugaga gccgagcuga      480

gagugaccga gagaagggcc gaggugccca ccgcccaccc cagccccagc cccagacccg      540

ccggccaguu ccagacccug guggugggcg uggugggcgg ccugcugggc agccuggugc      600

ugcuggugug ggugcuggcc gugaucugca gcagagccgc cagaggcacc aucggcgcca      660

gaagaaccgg ccagccccug aaggaggacc ccagcgccgu gcccguguuc agcguggacu      720

acggcgagcu ggacuuccag uggagagaga agacccccga gccccccgug cccugcgugc      780

ccgagcagac cgaguacgcc accaucgugu uccccagcgg caugggcacc agcagccccg      840

ccagaagagg cagcgccgac ggccccagaa gcgcccagcc ccugagaccc gaggacggcc      900

acugcagcug gccccuguga ggacuagugc aucacauuua aaagcaucuc agccuaccau      960

gagaauaaga gaaagaaaau gaagaucaau agcuuauuca ucucuuuuuc uuuuucguug     1020

guguaaagcc aacacccugu cuaaaaaaca uaaauuucuu uaaucauuuu gccucuuuuc     1080

ucugugcuuc aauuaauaaa aaauggaaag aaccuagauc uaaaaaaaaa aaaaaaaaaa     1140

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaugcau cccccccccc     1200

cccccccccc cccccccccc caaaggcucu uuucagagcc accagaauu                 1249


<210>  332
<211>  832
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  PDCD1(1-149) mRNA product TOP UTR opt4

<400>  332
ggggcgcugc cuacggaggu ggcagccauc uccuucucgg caucaagcuu accaugcaga       60

ucccccaggc ccccuggccc gugguguggg ccgugcugca gcugggcugg agacccggcu      120

gguuccugga cagccccgac agacccugga acccccccac cuucagcccc gcccugcugg      180

uggugaccga gggcgacaac gccaccuuca ccuguagcuu cagcaacacc agcgagagcu      240

ucgugcugaa cugguacaga augagcccca gcaaccagac cgacaagcug gccgccuucc      300

ccgaggacag aagccagccc ggccaggacu gcagauucag agugacccag cugcccaacg      360

gcagagacuu ccacaugagc guggugagag ccagaagaaa cgacagcggc accuaccugu      420

gcggcgccau cagccuggcc cccaaggccc agaucaagga gagccugaga gccgagcuga      480

gagugaccga gagaagggcc ugaggacuag ugcaucacau uuaaaagcau cucagccuac      540

caugagaaua agagaaagaa aaugaagauc aauagcuuau ucaucucuuu uucuuuuucg      600

uugguguaaa gccaacaccc ugucuaaaaa acauaaauuu cuuuaaucau uuugccucuu      660

uucucugugc uucaauuaau aaaaaaugga aagaaccuag aucuaaaaaa aaaaaaaaaa      720

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaug cauccccccc      780

cccccccccc cccccccccc ccccaaaggc ucuuuucaga gccaccagaa uu              832


<210>  333
<211>  1042
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  IL12A mRNA product TOP UTR opt4

<400>  333
ggggcgcugc cuacggaggu ggcagccauc uccuucucgg caucaagcuu accaugugcc       60

ccgccagaag ccugcugcug guggccaccc uggugcugcu ggaccaccug agccuggcca      120

gaaaccugcc cguggccacc cccgaccccg gcauguuccc cugccugcac cacagccaga      180

accugcugag agccgugagc aacaugcugc agaaggccag acagacccug gaguucuacc      240

ccugcaccag cgaggagauc gaccacgagg acaucaccaa ggacaagacc agcaccgugg      300

aggccugccu gccccuggag cugaccaaga acgagagcug ccugaacagc agagagacca      360

gcuucaucac caacggcagc ugccuggcca gcagaaagac cagcuucaug auggcccugu      420

gccugagcag caucuacgag gaccugaaga uguaccaggu ggaguucaag accaugaacg      480

ccaagcugcu gauggacccc aagagacaga ucuuccugga ccagaacaug cuggccguga      540

ucgacgagcu gaugcaggcc cugaacuuca acagcgagac cgugccccag aagaguagcc      600

uggaggagcc cgacuucuac aagaccaaga ucaagcugug cauccugcug cacgccuuca      660

gaaucagagc cgugaccauc gacagaguga ugagcuaccu gaacgccagc ugaggacuag      720

ugcaucacau uuaaaagcau cucagccuac caugagaaua agagaaagaa aaugaagauc      780

aauagcuuau ucaucucuuu uucuuuuucg uugguguaaa gccaacaccc ugucuaaaaa      840

acauaaauuu cuuuaaucau uuugccucuu uucucugugc uucaauuaau aaaaaaugga      900

aagaaccuag aucuaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa      960

aaaaaaaaaa aaaaaaaaug cauccccccc cccccccccc cccccccccc ccccaaaggc     1020

ucuuuucaga gccaccagaa uu                                              1042


<210>  334
<211>  1039
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  IL12A(1-219) mRNA product TOP UTR opt4

<400>  334
ggggcgcugc cuacggaggu ggcagccauc uccuucucgg caucaagcuu accaugugcc       60

ccgccagaag ccugcugcug guggccaccc uggugcugcu ggaccaccug agccuggcca      120

gaaaccugcc cguggccacc cccgaccccg gcauguuccc cugccugcac cacagccaga      180

accugcugag agccgugagc aacaugcugc agaaggccag acagacccug gaguucuacc      240

ccugcaccag cgaggagauc gaccacgagg acaucaccaa ggacaagacc agcaccgugg      300

aggccugccu gccccuggag cugaccaaga acgagagcug ccugaacagc agagagacca      360

gcuucaucac caacggcagc ugccuggcca gcagaaagac cagcuucaug auggcccugu      420

gccugagcag caucuacgag gaccugaaga uguaccaggu ggaguucaag accaugaacg      480

ccaagcugcu gauggacccc aagagacaga ucuuccugga ccagaacaug cuggccguga      540

ucgacgagcu gaugcaggcc cugaacuuca acagcgagac cgugccccag aagaguagcc      600

uggaggagcc cgacuucuac aagaccaaga ucaagcugug cauccugcug cacgccuuca      660

gaaucagagc cgugaccauc gacagaguga ugagcuaccu gaacgccagc ggacuagugc      720

aucacauuua aaagcaucuc agccuaccau gagaauaaga gaaagaaaau gaagaucaau      780

agcuuauuca ucucuuuuuc uuuuucguug guguaaagcc aacacccugu cuaaaaaaca      840

uaaauuucuu uaaucauuuu gccucuuuuc ucugugcuuc aauuaauaaa aaauggaaag      900

aaccuagauc uaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa      960

aaaaaaaaaa aaaaaugcau cccccccccc cccccccccc cccccccccc caaaggcucu     1020

uuucagagcc accagaauu                                                  1039


<210>  335
<211>  976
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  IL12A(23-219) mRNA product TOP UTR opt4

<400>  335
ggggcgcugc cuacggaggu ggcagccauc uccuucucgg caucaagcuu accagaaacc       60

ugcccguggc cacccccgac cccggcaugu uccccugccu gcaccacagc cagaaccugc      120

ugagagccgu gagcaacaug cugcagaagg ccagacagac ccuggaguuc uaccccugca      180

ccagcgagga gaucgaccac gaggacauca ccaaggacaa gaccagcacc guggaggccu      240

gccugccccu ggagcugacc aagaacgaga gcugccugaa cagcagagag accagcuuca      300

ucaccaacgg cagcugccug gccagcagaa agaccagcuu caugauggcc cugugccuga      360

gcagcaucua cgaggaccug aagauguacc agguggaguu caagaccaug aacgccaagc      420

ugcugaugga ccccaagaga cagaucuucc uggaccagaa caugcuggcc gugaucgacg      480

agcugaugca ggcccugaac uucaacagcg agaccgugcc ccagaagagu agccuggagg      540

agcccgacuu cuacaagacc aagaucaagc ugugcauccu gcugcacgcc uucagaauca      600

gagccgugac caucgacaga gugaugagcu accugaacgc cagcugagga cuagugcauc      660

acauuuaaaa gcaucucagc cuaccaugag aauaagagaa agaaaaugaa gaucaauagc      720

uuauucaucu cuuuuucuuu uucguuggug uaaagccaac acccugucua aaaaacauaa      780

auuucuuuaa ucauuuugcc ucuuuucucu gugcuucaau uaauaaaaaa uggaaagaac      840

cuagaucuaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa      900

aaaaaaaaaa aaugcauccc cccccccccc cccccccccc ccccccccaa aggcucuuuu      960

cagagccacc agaauu                                                      976


<210>  336
<211>  1369
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  IL12B mRNA product TOP UTR opt4

<400>  336
ggggcgcugc cuacggaggu ggcagccauc uccuucucgg caucaagcuu accaugugcc       60

accagcagcu ggugaucagc ugguucagcc ugguguuccu ggccagcccc cugguggcca      120

ucugggagcu gaagaaggac guguacgugg uggagcugga cugguacccc gacgcccccg      180

gcgagauggu ggugcugacc ugcgacaccc ccgaggagga cggcaucacc uggacccugg      240

accagagcag cgaggugcug ggcagcggca agacccugac cauccaggug aaggaguucg      300

gcgacgccgg ccaguacacc ugucacaagg gcggcgaggu gcugagccac agccugcugc      360

ugcugcacaa gaaggaggac ggcaucugga gcaccgacau ccugaaggac cagaaggagc      420

ccaagaacaa gaccuuccug agaugcgagg ccaagaacua cagcggcaga uucaccuguu      480

gguggcugac caccaucagc accgaccuga ccuucagcgu gaagaguagc agaggcagca      540

gcgaccccca gggcgugacc ugcggcgccg ccacccugag cgccgagaga gugagaggcg      600

acaacaagga guacgaguac agcguggagu gccaggagga cagcgccugc cccgccgccg      660

aggagagccu gcccaucgag gugauggugg acgccgugca caagcugaag uacgagaacu      720

acaccagcag cuucuucauc agagacauca ucaagcccga cccccccaag aaccugcagc      780

ugaagccccu gaagaacagc agacaggugg aggugagcug ggaguacccc gacaccugga      840

gcacccccca cagcuacuuc agccugaccu ucugcgugca gguucagggc aagagcaaga      900

gagagaagaa ggacagagug uucaccgaca agaccagcgc caccgugauc ugcagaaaga      960

acgccagcau cagcgugaga gcccaggaca gauacuacag cagcagcugg agcgaguggg     1020

ccagcgugcc cugcagcuga ggacuagugc aucacauuua aaagcaucuc agccuaccau     1080

gagaauaaga gaaagaaaau gaagaucaau agcuuauuca ucucuuuuuc uuuuucguug     1140

guguaaagcc aacacccugu cuaaaaaaca uaaauuucuu uaaucauuuu gccucuuuuc     1200

ucugugcuuc aauuaauaaa aaauggaaag aaccuagauc uaaaaaaaaa aaaaaaaaaa     1260

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaugcau cccccccccc     1320

cccccccccc cccccccccc caaaggcucu uuucagagcc accagaauu                 1369


<210>  337
<211>  1366
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  IL12B(1-328) mRNA product TOP UTR opt4

<400>  337
ggggcgcugc cuacggaggu ggcagccauc uccuucucgg caucaagcuu accaugugcc       60

accagcagcu ggugaucagc ugguucagcc ugguguuccu ggccagcccc cugguggcca      120

ucugggagcu gaagaaggac guguacgugg uggagcugga cugguacccc gacgcccccg      180

gcgagauggu ggugcugacc ugcgacaccc ccgaggagga cggcaucacc uggacccugg      240

accagagcag cgaggugcug ggcagcggca agacccugac cauccaggug aaggaguucg      300

gcgacgccgg ccaguacacc ugucacaagg gcggcgaggu gcugagccac agccugcugc      360

ugcugcacaa gaaggaggac ggcaucugga gcaccgacau ccugaaggac cagaaggagc      420

ccaagaacaa gaccuuccug agaugcgagg ccaagaacua cagcggcaga uucaccuguu      480

gguggcugac caccaucagc accgaccuga ccuucagcgu gaagaguagc agaggcagca      540

gcgaccccca gggcgugacc ugcggcgccg ccacccugag cgccgagaga gugagaggcg      600

acaacaagga guacgaguac agcguggagu gccaggagga cagcgccugc cccgccgccg      660

aggagagccu gcccaucgag gugauggugg acgccgugca caagcugaag uacgagaacu      720

acaccagcag cuucuucauc agagacauca ucaagcccga cccccccaag aaccugcagc      780

ugaagccccu gaagaacagc agacaggugg aggugagcug ggaguacccc gacaccugga      840

gcacccccca cagcuacuuc agccugaccu ucugcgugca gguucagggc aagagcaaga      900

gagagaagaa ggacagagug uucaccgaca agaccagcgc caccgugauc ugcagaaaga      960

acgccagcau cagcgugaga gcccaggaca gauacuacag cagcagcugg agcgaguggg     1020

ccagcgugcc cugcagcgga cuagugcauc acauuuaaaa gcaucucagc cuaccaugag     1080

aauaagagaa agaaaaugaa gaucaauagc uuauucaucu cuuuuucuuu uucguuggug     1140

uaaagccaac acccugucua aaaaacauaa auuucuuuaa ucauuuugcc ucuuuucucu     1200

gugcuucaau uaauaaaaaa uggaaagaac cuagaucuaa aaaaaaaaaa aaaaaaaaaa     1260

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaugcauccc cccccccccc     1320

cccccccccc ccccccccaa aggcucuuuu cagagccacc agaauu                    1366


<210>  338
<211>  1303
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  IL12B(23-328) mRNA product TOP UTR opt4

<400>  338
ggggcgcugc cuacggaggu ggcagccauc uccuucucgg caucaagcuu accaucuggg       60

agcugaagaa ggacguguac gugguggagc uggacuggua ccccgacgcc cccggcgaga      120

ugguggugcu gaccugcgac acccccgagg aggacggcau caccuggacc cuggaccaga      180

gcagcgaggu gcugggcagc ggcaagaccc ugaccaucca ggugaaggag uucggcgacg      240

ccggccagua caccugucac aagggcggcg aggugcugag ccacagccug cugcugcugc      300

acaagaagga ggacggcauc uggagcaccg acauccugaa ggaccagaag gagcccaaga      360

acaagaccuu ccugagaugc gaggccaaga acuacagcgg cagauucacc uguugguggc      420

ugaccaccau cagcaccgac cugaccuuca gcgugaagag uagcagaggc agcagcgacc      480

cccagggcgu gaccugcggc gccgccaccc ugagcgccga gagagugaga ggcgacaaca      540

aggaguacga guacagcgug gagugccagg aggacagcgc cugccccgcc gccgaggaga      600

gccugcccau cgaggugaug guggacgccg ugcacaagcu gaaguacgag aacuacacca      660

gcagcuucuu caucagagac aucaucaagc ccgacccccc caagaaccug cagcugaagc      720

cccugaagaa cagcagacag guggagguga gcugggagua ccccgacacc uggagcaccc      780

cccacagcua cuucagccug accuucugcg ugcagguuca gggcaagagc aagagagaga      840

agaaggacag aguguucacc gacaagacca gcgccaccgu gaucugcaga aagaacgcca      900

gcaucagcgu gagagcccag gacagauacu acagcagcag cuggagcgag ugggccagcg      960

ugcccugcag cugaggacua gugcaucaca uuuaaaagca ucucagccua ccaugagaau     1020

aagagaaaga aaaugaagau caauagcuua uucaucucuu uuucuuuuuc guugguguaa     1080

agccaacacc cugucuaaaa aacauaaauu ucuuuaauca uuuugccucu uuucucugug     1140

cuucaauuaa uaaaaaaugg aaagaaccua gaucuaaaaa aaaaaaaaaa aaaaaaaaaa     1200

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaau gcaucccccc cccccccccc     1260

cccccccccc cccccaaagg cucuuuucag agccaccaga auu                       1303


<210>  339
<211>  436
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Linker-sFvCC49-218 mRNA product TOP UTR opt4

<400>  339
ggggcgcugc cuacggaggu ggcagccauc uccuucucgg caucaagcuu accggcagca       60

ccagcggcag cggcaagccc ggcagcggcg agggcagcac caagggcgga cuagugcauc      120

acauuuaaaa gcaucucagc cuaccaugag aauaagagaa agaaaaugaa gaucaauagc      180

uuauucaucu cuuuuucuuu uucguuggug uaaagccaac acccugucua aaaaacauaa      240

auuucuuuaa ucauuuugcc ucuuuucucu gugcuucaau uaauaaaaaa uggaaagaac      300

cuagaucuaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa      360

aaaaaaaaaa aaugcauccc cccccccccc cccccccccc ccccccccaa aggcucuuuu      420

cagagccacc agaauu                                                      436


<210>  340
<211>  2014
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  IL12 mRNA product TOP UTR opt4

<400>  340
ggggcgcugc cuacggaggu ggcagccauc uccuucucgg caucaagcuu accaugugcc       60

accagcagcu ggugaucagc ugguucagcc ugguguuccu ggccagcccc cugguggcca      120

ucugggagcu gaagaaggac guguacgugg uggagcugga cugguacccc gacgcccccg      180

gcgagauggu ggugcugacc ugcgacaccc ccgaggagga cggcaucacc uggacccugg      240

accagagcag cgaggugcug ggcagcggca agacccugac cauccaggug aaggaguucg      300

gcgacgccgg ccaguacacc ugucacaagg gcggcgaggu gcugagccac agccugcugc      360

ugcugcacaa gaaggaggac ggcaucugga gcaccgacau ccugaaggac cagaaggagc      420

ccaagaacaa gaccuuccug agaugcgagg ccaagaacua cagcggcaga uucaccuguu      480

gguggcugac caccaucagc accgaccuga ccuucagcgu gaagaguagc agaggcagca      540

gcgaccccca gggcgugacc ugcggcgccg ccacccugag cgccgagaga gugagaggcg      600

acaacaagga guacgaguac agcguggagu gccaggagga cagcgccugc cccgccgccg      660

aggagagccu gcccaucgag gugauggugg acgccgugca caagcugaag uacgagaacu      720

acaccagcag cuucuucauc agagacauca ucaagcccga cccccccaag aaccugcagc      780

ugaagccccu gaagaacagc agacaggugg aggugagcug ggaguacccc gacaccugga      840

gcacccccca cagcuacuuc agccugaccu ucugcgugca gguucagggc aagagcaaga      900

gagagaagaa ggacagagug uucaccgaca agaccagcgc caccgugauc ugcagaaaga      960

acgccagcau cagcgugaga gcccaggaca gauacuacag cagcagcugg agcgaguggg     1020

ccagcgugcc cugcagcggc agcaccagcg gcagcggcaa gcccggcagc ggcgagggca     1080

gcaccaaggg cagaaaccug cccguggcca cccccgaccc cggcauguuc cccugccugc     1140

accacagcca gaaccugcug agagccguga gcaacaugcu gcagaaggcc agacagaccc     1200

uggaguucua ccccugcacc agcgaggaga ucgaccacga ggacaucacc aaggacaaga     1260

ccagcaccgu ggaggccugc cugccccugg agcugaccaa gaacgagagc ugccugaaca     1320

gcagagagac cagcuucauc accaacggca gcugccuggc cagcagaaag accagcuuca     1380

ugauggcccu gugccugagc agcaucuacg aggaccugaa gauguaccag guggaguuca     1440

agaccaugaa cgccaagcug cugauggacc ccaagagaca gaucuuccug gaccagaaca     1500

ugcuggccgu gaucgacgag cugaugcagg cccugaacuu caacagcgag accgugcccc     1560

agaagaguag ccuggaggag cccgacuucu acaagaccaa gaucaagcug ugcauccugc     1620

ugcacgccuu cagaaucaga gccgugacca ucgacagagu gaugagcuac cugaacgcca     1680

gcugaggacu agugcaucac auuuaaaagc aucucagccu accaugagaa uaagagaaag     1740

aaaaugaaga ucaauagcuu auucaucucu uuuucuuuuu cguuggugua aagccaacac     1800

ccugucuaaa aaacauaaau uucuuuaauc auuuugccuc uuuucucugu gcuucaauua     1860

auaaaaaaug gaaagaaccu agaucuaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa     1920

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa ugcauccccc cccccccccc cccccccccc     1980

ccccccaaag gcucuuuuca gagccaccag aauu                                 2014


<210>  341
<211>  1168
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  CD40LG mRNA product TOP UTR opt4

<400>  341
ggggcgcugc cuacggaggu ggcagccauc uccuucucgg caucaagcuu accaugaucg       60

agaccuacaa ccagaccagc cccagaagcg ccgccaccgg ccugcccauc agcaugaaga      120

ucuucaugua ccugcugacc guguuccuga ucacccagau gaucggcagc gcccuguucg      180

ccguguaccu gcacagaaga cuggacaaga ucgaggacga gagaaaccug cacgaggacu      240

ucguguucau gaagaccauc cagagaugca acaccggcga gagaagccug agccugcuga      300

acugcgagga gaucaagagc caguucgagg gcuucgugaa ggacaucaug cugaacaagg      360

aggagaccaa gaaggagaac agcuucgaga ugcagaaggg cgaccagaac ccccagaucg      420

ccgcccacgu gaucagcgag gccagcagca agaccaccag cgugcugcag ugggccgaga      480

agggcuacua caccaugagc aacaaccugg ugacccugga gaacggcaag cagcugaccg      540

ugaagagaca gggccuguac uacaucuacg cccaggugac cuucugcagc aacagagagg      600

ccagcagcca ggcccccuuc aucgccagcc ugugccugaa gagucccggc agauucgaga      660

gaauccugcu gagagccgcc aacacccaca gcagcgccaa gcccugcggc cagcagagca      720

uccaccuggg cggcguguuc gagcugcagc ccggcgccag cguguucgug aacgugaccg      780

accccagcca ggugagccac ggcaccggcu ucaccagcuu cggccugcug aagcugugag      840

gacuagugca ucacauuuaa aagcaucuca gccuaccaug agaauaagag aaagaaaaug      900

aagaucaaua gcuuauucau cucuuuuucu uuuucguugg uguaaagcca acacccuguc      960

uaaaaaacau aaauuucuuu aaucauuuug ccucuuuucu cugugcuuca auuaauaaaa     1020

aauggaaaga accuagaucu aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa     1080

aaaaaaaaaa aaaaaaaaaa aaaaugcauc cccccccccc cccccccccc cccccccccc     1140

aaaggcucuu uucagagcca ccagaauu                                        1168


<210>  342
<211>  1249
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  PDCD1 mRNA product TOP UTR opt5

<400>  342
ggggcgcugc cuacggaggu ggcagccauc uccuucucgg caucaagcuu accaugcaga       60

ucccccaagc cccuuggccg guggucuggg cuguucugca gcucggcugg agacccgggu      120

gguuccugga cagcccugau cggcccugga acccucccac cuuuuccccu gcccuucugg      180

uggugacaga gggagacaau gcgacguuua ccugcucuuu cagcaacaca uccgaaucuu      240

ucguccucaa uugguaccgc augagcccgu ccaaccagac cgauaagcug gcugccuuuc      300

ccgaggacag aucucagccu ggccaagauu gucgguuccg cgugacacag cuucccaaug      360

ggagagacuu ucacaugagc guugugcggg cccgcagaaa cgauuccgga accuaucugu      420

gcggcgcuau uagccucgcc ccuaaagcuc agaucaagga aucucugcgg gccgagcugc      480

gcgucacaga aagacgggcg gaggugccca ccgcccaucc guccccuagc ccccgcccug      540

cugggcaguu ccaaacgcuc guugugggag ucgugggcgg ccugcuuggg ucucuggugc      600

uccuggucug gguucuugcc gugauuuguu ccagagcugc ccggggaacc aucggcgcgc      660

gcagaacagg gcagccccug aaagaggacc ccagcgccgu gccugucuuu ucuguggauu      720

acggagaacu cgacuuccag uggcgggaga agaccccgga acccccuguu cccugcgugc      780

cugagcagac agaguaugcu accauugucu uucccuccgg cauggggacg agcuccccgg      840

ccagacgcgg aucugcugau ggcccucgga gcgcccaacc ccugagaccu gaagacggcc      900

acuguuccug gccccuguga ggacuagugc aucacauuua aaagcaucuc agccuaccau      960

gagaauaaga gaaagaaaau gaagaucaau agcuuauuca ucucuuuuuc uuuuucguug     1020

guguaaagcc aacacccugu cuaaaaaaca uaaauuucuu uaaucauuuu gccucuuuuc     1080

ucugugcuuc aauuaauaaa aaauggaaag aaccuagauc uaaaaaaaaa aaaaaaaaaa     1140

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaugcau cccccccccc     1200

cccccccccc cccccccccc caaaggcucu uuucagagcc accagaauu                 1249


<210>  343
<211>  832
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  PDCD1(1-149) mRNA product TOP UTR opt5

<400>  343
ggggcgcugc cuacggaggu ggcagccauc uccuucucgg caucaagcuu accaugcaga       60

ucccccaagc cccuuggccg guggucuggg cuguucugca gcucggcugg agacccgggu      120

gguuccugga cagcccugau cggcccugga acccucccac cuuuuccccu gcccuucugg      180

uggugacaga gggagacaau gcgacguuua ccugcucuuu cagcaacaca uccgaaucuu      240

ucguccucaa uugguaccgc augagcccgu ccaaccagac cgauaagcug gcugccuuuc      300

ccgaggacag aucucagccu ggccaagauu gucgguuccg cgugacacag cuucccaaug      360

ggagagacuu ucacaugagc guugugcggg cccgcagaaa cgauuccgga accuaucugu      420

gcggcgcuau uagccucgcc ccuaaagcuc agaucaagga aucucugcgg gccgagcugc      480

gcgucacaga aagacgggcg ugaggacuag ugcaucacau uuaaaagcau cucagccuac      540

caugagaaua agagaaagaa aaugaagauc aauagcuuau ucaucucuuu uucuuuuucg      600

uugguguaaa gccaacaccc ugucuaaaaa acauaaauuu cuuuaaucau uuugccucuu      660

uucucugugc uucaauuaau aaaaaaugga aagaaccuag aucuaaaaaa aaaaaaaaaa      720

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaug cauccccccc      780

cccccccccc cccccccccc ccccaaaggc ucuuuucaga gccaccagaa uu              832


<210>  344
<211>  1042
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  IL12A mRNA product TOP UTR opt5

<400>  344
ggggcgcugc cuacggaggu ggcagccauc uccuucucgg caucaagcuu accaugugcc       60

ccgccagaag ccugcuccug guggcuaccc uuguccugcu cgaccaccug ucccuugccc      120

ggaaccugcc uguugcgaca ccggaucccg gcauguuccc uugucuccau cacucucaga      180

aucugcugcg cgcugugagc aacaugcucc aaaaggccag acagacgcug gaguuuuacc      240

ccugcaccuc cgaagagauc gaccaugaag auauuacaaa agacaagacc ucuacagugg      300

aggccugucu uccucuggaa cucaccaaaa augagagcug ccugaacucc cgggagacau      360

cuuucaucac caaugggagc ugucuugcuu cccgcaagac gagcuuuaug auggcccugu      420

gccucucuuc cauuuaugaa gaucugaaaa uguaccaggu cgaguucaag accaugaacg      480

cuaagcugcu cauggacccc aaaagacaga ucuuucugga ucaaaauaug cuugccguga      540

uugacgaacu gaugcaggcg cucaacuuca auagcgagac aguuccucag aagucuuccc      600

uggaggaacc ggauuuuuau aaaaccaaga ucaaacuuug uauccugcuc cacgccuucc      660

ggauucgcgc ugugacaauc gacagaguca ugagcuaccu gaacgccucu ugaggacuag      720

ugcaucacau uuaaaagcau cucagccuac caugagaaua agagaaagaa aaugaagauc      780

aauagcuuau ucaucucuuu uucuuuuucg uugguguaaa gccaacaccc ugucuaaaaa      840

acauaaauuu cuuuaaucau uuugccucuu uucucugugc uucaauuaau aaaaaaugga      900

aagaaccuag aucuaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa      960

aaaaaaaaaa aaaaaaaaug cauccccccc cccccccccc cccccccccc ccccaaaggc     1020

ucuuuucaga gccaccagaa uu                                              1042


<210>  345
<211>  1039
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  IL12A(1-219) mRNA product TOP UTR opt5

<400>  345
ggggcgcugc cuacggaggu ggcagccauc uccuucucgg caucaagcuu accaugugcc       60

ccgccagaag ccugcuccug guggcuaccc uuguccugcu cgaccaccug ucccuugccc      120

ggaaccugcc uguugcgaca ccggaucccg gcauguuccc uugucuccau cacucucaga      180

aucugcugcg cgcugugagc aacaugcucc aaaaggccag acagacgcug gaguuuuacc      240

ccugcaccuc cgaagagauc gaccaugaag auauuacaaa agacaagacc ucuacagugg      300

aggccugucu uccucuggaa cucaccaaaa augagagcug ccugaacucc cgggagacau      360

cuuucaucac caaugggagc ugucuugcuu cccgcaagac gagcuuuaug auggcccugu      420

gccucucuuc cauuuaugaa gaucugaaaa uguaccaggu cgaguucaag accaugaacg      480

cuaagcugcu cauggacccc aaaagacaga ucuuucugga ucaaaauaug cuugccguga      540

uugacgaacu gaugcaggcg cucaacuuca auagcgagac aguuccucag aagucuuccc      600

uggaggaacc ggauuuuuau aaaaccaaga ucaaacuuug uauccugcuc cacgccuucc      660

ggauucgcgc ugugacaauc gacagaguca ugagcuaccu gaacgccucu ggacuagugc      720

aucacauuua aaagcaucuc agccuaccau gagaauaaga gaaagaaaau gaagaucaau      780

agcuuauuca ucucuuuuuc uuuuucguug guguaaagcc aacacccugu cuaaaaaaca      840

uaaauuucuu uaaucauuuu gccucuuuuc ucugugcuuc aauuaauaaa aaauggaaag      900

aaccuagauc uaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa      960

aaaaaaaaaa aaaaaugcau cccccccccc cccccccccc cccccccccc caaaggcucu     1020

uuucagagcc accagaauu                                                  1039


<210>  346
<211>  976
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  IL12A(23-219) mRNA product TOP UTR opt5

<400>  346
ggggcgcugc cuacggaggu ggcagccauc uccuucucgg caucaagcuu acccggaacc       60

ugccuguugc gacaccggau cccggcaugu ucccuugucu ccaucacucu cagaaucugc      120

ugcgcgcugu gagcaacaug cuccaaaagg ccagacagac gcuggaguuu uaccccugca      180

ccuccgaaga gaucgaccau gaagauauua caaaagacaa gaccucuaca guggaggccu      240

gucuuccucu ggaacucacc aaaaaugaga gcugccugaa cucccgggag acaucuuuca      300

ucaccaaugg gagcugucuu gcuucccgca agacgagcuu uaugauggcc cugugccucu      360

cuuccauuua ugaagaucug aaaauguacc aggucgaguu caagaccaug aacgcuaagc      420

ugcucaugga ccccaaaaga cagaucuuuc uggaucaaaa uaugcuugcc gugauugacg      480

aacugaugca ggcgcucaac uucaauagcg agacaguucc ucagaagucu ucccuggagg      540

aaccggauuu uuauaaaacc aagaucaaac uuuguauccu gcuccacgcc uuccggauuc      600

gcgcugugac aaucgacaga gucaugagcu accugaacgc cucuugagga cuagugcauc      660

acauuuaaaa gcaucucagc cuaccaugag aauaagagaa agaaaaugaa gaucaauagc      720

uuauucaucu cuuuuucuuu uucguuggug uaaagccaac acccugucua aaaaacauaa      780

auuucuuuaa ucauuuugcc ucuuuucucu gugcuucaau uaauaaaaaa uggaaagaac      840

cuagaucuaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa      900

aaaaaaaaaa aaugcauccc cccccccccc cccccccccc ccccccccaa aggcucuuuu      960

cagagccacc agaauu                                                      976


<210>  347
<211>  1369
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  IL12B mRNA product TOP UTR opt5

<400>  347
ggggcgcugc cuacggaggu ggcagccauc uccuucucgg caucaagcuu accaugugcc       60

accagcaacu ggugaucagc ugguucuccc ucgucuuucu ggccucuccc cuuguugcua      120

uuugggagcu gaagaaagac guguacgugg ucgaacucga uugguauccu gacgccccgg      180

gcgagauggu gguucugacc ugugauacac ccgaagagga cgggaucacg uggacccuug      240

aucagagcuc cgaagugcug ggaucuggca agacacucac cauucagguc aaagaguucg      300

gggacgcggg acaguacaca ugccauaagg gcggggaggu gcugagccac ucccugcucc      360

ugcuucauaa aaaggaagau ggaaucuggu cuaccgacau ucugaaggau caaaaagagc      420

cuaagaacaa aacauuucuc agaugugaag cuaagaauua uagcggccgg uuuaccugcu      480

gguggcugac gaccaucucc acagaccuua ccuucagcgu uaaaucuucc cgcggcagcu      540

cugaucccca gggggugaca uguggagccg ccacccuguc cgcugagaga guccggggcg      600

acaacaagga guacgaauau agcguggagu gccaggaaga uucugccugu ccugcugccg      660

aggaaucccu ccccaucgag gugauggucg acgcgguuca caagcugaaa uacgagaauu      720

auacgagcuc cuucuuuauu cgcgacauca uuaagccuga uccgcccaaa aaccugcagc      780

ucaagccucu gaaaaauucu agacaagugg aagugagcug ggaguacccc gacacauggu      840

ccaccccuca uagcuacuuc ucucuuacau uuugcgucca ggugcagggg aaguccaaac      900

gggaaaagaa ggaucgcguu uucaccgaca aaaccagcgc cacagugauc uguagaaaga      960

acgcuucuau uagcguccgg gcccaggauc gcuauuacuc cucuagcugg uccgaguggg     1020

cuagcgugcc cugcucuuga ggacuagugc aucacauuua aaagcaucuc agccuaccau     1080

gagaauaaga gaaagaaaau gaagaucaau agcuuauuca ucucuuuuuc uuuuucguug     1140

guguaaagcc aacacccugu cuaaaaaaca uaaauuucuu uaaucauuuu gccucuuuuc     1200

ucugugcuuc aauuaauaaa aaauggaaag aaccuagauc uaaaaaaaaa aaaaaaaaaa     1260

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaugcau cccccccccc     1320

cccccccccc cccccccccc caaaggcucu uuucagagcc accagaauu                 1369


<210>  348
<211>  1366
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  IL12B(1-328) mRNA product TOP UTR opt5

<400>  348
ggggcgcugc cuacggaggu ggcagccauc uccuucucgg caucaagcuu accaugugcc       60

accagcaacu ggugaucagc ugguucuccc ucgucuuucu ggccucuccc cuuguugcua      120

uuugggagcu gaagaaagac guguacgugg ucgaacucga uugguauccu gacgccccgg      180

gcgagauggu gguucugacc ugugauacac ccgaagagga cgggaucacg uggacccuug      240

aucagagcuc cgaagugcug ggaucuggca agacacucac cauucagguc aaagaguucg      300

gggacgcggg acaguacaca ugccauaagg gcggggaggu gcugagccac ucccugcucc      360

ugcuucauaa aaaggaagau ggaaucuggu cuaccgacau ucugaaggau caaaaagagc      420

cuaagaacaa aacauuucuc agaugugaag cuaagaauua uagcggccgg uuuaccugcu      480

gguggcugac gaccaucucc acagaccuua ccuucagcgu uaaaucuucc cgcggcagcu      540

cugaucccca gggggugaca uguggagccg ccacccuguc cgcugagaga guccggggcg      600

acaacaagga guacgaauau agcguggagu gccaggaaga uucugccugu ccugcugccg      660

aggaaucccu ccccaucgag gugauggucg acgcgguuca caagcugaaa uacgagaauu      720

auacgagcuc cuucuuuauu cgcgacauca uuaagccuga uccgcccaaa aaccugcagc      780

ucaagccucu gaaaaauucu agacaagugg aagugagcug ggaguacccc gacacauggu      840

ccaccccuca uagcuacuuc ucucuuacau uuugcgucca ggugcagggg aaguccaaac      900

gggaaaagaa ggaucgcguu uucaccgaca aaaccagcgc cacagugauc uguagaaaga      960

acgcuucuau uagcguccgg gcccaggauc gcuauuacuc cucuagcugg uccgaguggg     1020

cuagcgugcc cugcucugga cuagugcauc acauuuaaaa gcaucucagc cuaccaugag     1080

aauaagagaa agaaaaugaa gaucaauagc uuauucaucu cuuuuucuuu uucguuggug     1140

uaaagccaac acccugucua aaaaacauaa auuucuuuaa ucauuuugcc ucuuuucucu     1200

gugcuucaau uaauaaaaaa uggaaagaac cuagaucuaa aaaaaaaaaa aaaaaaaaaa     1260

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaugcauccc cccccccccc     1320

cccccccccc ccccccccaa aggcucuuuu cagagccacc agaauu                    1366


<210>  349
<211>  1303
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  IL12B(23-328) mRNA product TOP UTR opt5

<400>  349
ggggcgcugc cuacggaggu ggcagccauc uccuucucgg caucaagcuu accauuuggg       60

agcugaagaa agacguguac guggucgaac ucgauuggua uccugacgcc ccgggcgaga      120

uggugguucu gaccugugau acacccgaag aggacgggau cacguggacc cuugaucaga      180

gcuccgaagu gcugggaucu ggcaagacac ucaccauuca ggucaaagag uucggggacg      240

cgggacagua cacaugccau aagggcgggg aggugcugag ccacucccug cuccugcuuc      300

auaaaaagga agauggaauc uggucuaccg acauucugaa ggaucaaaaa gagccuaaga      360

acaaaacauu ucucagaugu gaagcuaaga auuauagcgg ccgguuuacc ugcugguggc      420

ugacgaccau cuccacagac cuuaccuuca gcguuaaauc uucccgcggc agcucugauc      480

cccagggggu gacaugugga gccgccaccc uguccgcuga gagaguccgg ggcgacaaca      540

aggaguacga auauagcgug gagugccagg aagauucugc cuguccugcu gccgaggaau      600

cccuccccau cgaggugaug gucgacgcgg uucacaagcu gaaauacgag aauuauacga      660

gcuccuucuu uauucgcgac aucauuaagc cugauccgcc caaaaaccug cagcucaagc      720

cucugaaaaa uucuagacaa guggaaguga gcugggagua ccccgacaca ugguccaccc      780

cucauagcua cuucucucuu acauuuugcg uccaggugca ggggaagucc aaacgggaaa      840

agaaggaucg cguuuucacc gacaaaacca gcgccacagu gaucuguaga aagaacgcuu      900

cuauuagcgu ccgggcccag gaucgcuauu acuccucuag cugguccgag ugggcuagcg      960

ugcccugcuc uugaggacua gugcaucaca uuuaaaagca ucucagccua ccaugagaau     1020

aagagaaaga aaaugaagau caauagcuua uucaucucuu uuucuuuuuc guugguguaa     1080

agccaacacc cugucuaaaa aacauaaauu ucuuuaauca uuuugccucu uuucucugug     1140

cuucaauuaa uaaaaaaugg aaagaaccua gaucuaaaaa aaaaaaaaaa aaaaaaaaaa     1200

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaau gcaucccccc cccccccccc     1260

cccccccccc cccccaaagg cucuuuucag agccaccaga auu                       1303


<210>  350
<211>  436
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Linker-sFvCC49-218 mRNA product TOP UTR opt5

<400>  350
ggggcgcugc cuacggaggu ggcagccauc uccuucucgg caucaagcuu accggcagca       60

ccuccggguc uggaaagccc ggcagcgggg agggauccac aaaaggcgga cuagugcauc      120

acauuuaaaa gcaucucagc cuaccaugag aauaagagaa agaaaaugaa gaucaauagc      180

uuauucaucu cuuuuucuuu uucguuggug uaaagccaac acccugucua aaaaacauaa      240

auuucuuuaa ucauuuugcc ucuuuucucu gugcuucaau uaauaaaaaa uggaaagaac      300

cuagaucuaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa      360

aaaaaaaaaa aaugcauccc cccccccccc cccccccccc ccccccccaa aggcucuuuu      420

cagagccacc agaauu                                                      436


<210>  351
<211>  2014
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  IL12 mRNA product TOP UTR opt5

<400>  351
ggggcgcugc cuacggaggu ggcagccauc uccuucucgg caucaagcuu accaugugcc       60

accagcaacu ggugaucagc ugguucuccc ucgucuuucu ggccucuccc cuuguugcua      120

uuugggagcu gaagaaagac guguacgugg ucgaacucga uugguauccu gacgccccgg      180

gcgagauggu gguucugacc ugugauacac ccgaagagga cgggaucacg uggacccuug      240

aucagagcuc cgaagugcug ggaucuggca agacacucac cauucagguc aaagaguucg      300

gggacgcggg acaguacaca ugccauaagg gcggggaggu gcugagccac ucccugcucc      360

ugcuucauaa aaaggaagau ggaaucuggu cuaccgacau ucugaaggau caaaaagagc      420

cuaagaacaa aacauuucuc agaugugaag cuaagaauua uagcggccgg uuuaccugcu      480

gguggcugac gaccaucucc acagaccuua ccuucagcgu uaaaucuucc cgcggcagcu      540

cugaucccca gggggugaca uguggagccg ccacccuguc cgcugagaga guccggggcg      600

acaacaagga guacgaauau agcguggagu gccaggaaga uucugccugu ccugcugccg      660

aggaaucccu ccccaucgag gugauggucg acgcgguuca caagcugaaa uacgagaauu      720

auacgagcuc cuucuuuauu cgcgacauca uuaagccuga uccgcccaaa aaccugcagc      780

ucaagccucu gaaaaauucu agacaagugg aagugagcug ggaguacccc gacacauggu      840

ccaccccuca uagcuacuuc ucucuuacau uuugcgucca ggugcagggg aaguccaaac      900

gggaaaagaa ggaucgcguu uucaccgaca aaaccagcgc cacagugauc uguagaaaga      960

acgcuucuau uagcguccgg gcccaggauc gcuauuacuc cucuagcugg uccgaguggg     1020

cuagcgugcc cugcucuggc agcaccuccg ggucuggaaa gcccggcagc ggggagggau     1080

ccacaaaagg ccggaaccug ccuguugcga caccggaucc cggcauguuc ccuugucucc     1140

aucacucuca gaaucugcug cgcgcuguga gcaacaugcu ccaaaaggcc agacagacgc     1200

uggaguuuua ccccugcacc uccgaagaga ucgaccauga agauauuaca aaagacaaga     1260

ccucuacagu ggaggccugu cuuccucugg aacucaccaa aaaugagagc ugccugaacu     1320

cccgggagac aucuuucauc accaauggga gcugucuugc uucccgcaag acgagcuuua     1380

ugauggcccu gugccucucu uccauuuaug aagaucugaa aauguaccag gucgaguuca     1440

agaccaugaa cgcuaagcug cucauggacc ccaaaagaca gaucuuucug gaucaaaaua     1500

ugcuugccgu gauugacgaa cugaugcagg cgcucaacuu caauagcgag acaguuccuc     1560

agaagucuuc ccuggaggaa ccggauuuuu auaaaaccaa gaucaaacuu uguauccugc     1620

uccacgccuu ccggauucgc gcugugacaa ucgacagagu caugagcuac cugaacgccu     1680

cuugaggacu agugcaucac auuuaaaagc aucucagccu accaugagaa uaagagaaag     1740

aaaaugaaga ucaauagcuu auucaucucu uuuucuuuuu cguuggugua aagccaacac     1800

ccugucuaaa aaacauaaau uucuuuaauc auuuugccuc uuuucucugu gcuucaauua     1860

auaaaaaaug gaaagaaccu agaucuaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa     1920

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa ugcauccccc cccccccccc cccccccccc     1980

ccccccaaag gcucuuuuca gagccaccag aauu                                 2014


<210>  352
<211>  1168
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  CD40LG mRNA product TOP UTR opt5

<400>  352
ggggcgcugc cuacggaggu ggcagccauc uccuucucgg caucaagcuu accaugaucg       60

agaccuacaa ccagacaagc cccagauccg ccgcuacggg ccugccuauu ucuaugaaga      120

ucuucaugua ucuccugacc guguuucuua uuacacaaau gaucgggagc gcccuguucg      180

cggucuaccu ccaccggcgc cuggacaaaa uugaagauga gagaaaucuu caugaagacu      240

uuguuuucau gaagaccauc cagcggugca acacaggaga gcgcucccug ucucuccuga      300

auugugaaga gaucaaaagc caguuugagg gcuucgugaa ggauauuaug cugaacaaag      360

aagagaccaa gaaggaaaau uccuuugaga ugcagaaagg ggaccaaaac ccgcagaucg      420

cugcccacgu gauuucugag gccagcucca agacaaccag cguccuccag ugggcugaaa      480

aaggauauua cacgaugucu aauaaccugg ugacccuuga gaauggcaag cagcugacag      540

uuaaaagaca agggcucuau uacaucuaug cccaggugac cuucugcucc aaccgggaag      600

cuagcucuca ggcccccuuu auugcguccc ugugucuuaa gagcccugga cgcuucgaga      660

gaauccugcu ccgggccgcu aauacacauu cuuccgccaa gcccugcggc cagcaaagca      720

uucaccuggg cggggucuuu gaacugcagc cuggagcuuc cguguucguu aacgugaccg      780

aucccucuca ggucagccau ggcacggggu uuacauccuu cggacuccug aaacuuugag      840

gacuagugca ucacauuuaa aagcaucuca gccuaccaug agaauaagag aaagaaaaug      900

aagaucaaua gcuuauucau cucuuuuucu uuuucguugg uguaaagcca acacccuguc      960

uaaaaaacau aaauuucuuu aaucauuuug ccucuuuucu cugugcuuca auuaauaaaa     1020

aauggaaaga accuagaucu aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa     1080

aaaaaaaaaa aaaaaaaaaa aaaaugcauc cccccccccc cccccccccc cccccccccc     1140

aaaggcucuu uucagagcca ccagaauu                                        1168


<210>  353
<211>  1249
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  PDCD1 mRNA product TOP UTR opt6

<400>  353
ggggcgcugc cuacggaggu ggcagccauc uccuucucgg caucaagcuu accaugcaaa       60

uaccacaagc accauggcca guaguauggg cuguacuaca auuagguugg cgaccaggau      120

gguuuuuaga cucaccagau cguccaugga acccaccaac auuuucacca gcauuauuag      180

uaguaacaga aggagauaau gcaaccuuua cauguucauu caguaacaca ucagaaaguu      240

uuguacuaaa uugguauaga augucaccuu caaaucaaac agauaaauua gcagcauuuc      300

cagaagauag aucacaacca ggacaagauu gcagauuuag aguaacacaa uuaccuaaug      360

gacgagacuu ucauauguca guaguaagag cucgacguaa cgauucagga acauacuuau      420

guggagcaau aucauuagca ccaaaagcac aaauaaaaga aucuuuaaga gcagaauuaa      480

gaguaacaga aagacgcgca gaaguaccaa cagcacaucc aagcccuuca ccacgaccug      540

caggacaauu ucaaacauua guagucggag uaguaggagg auuauuaggu ucacugguau      600

uauuaguaug gguauuagca guaauaugcu ccagagcagc aagaggaaca auaggagcaa      660

gaagaacagg acaaccauua aaagaagacc caucugcagu accaguauuu ucaguugacu      720

auggagaacu agauuuccaa uggagggaaa aaacaccaga accuccaguu ccauguguac      780

cagaacaaac agaauaugca acaauuguau uucccucagg aaugggaaca ucuaguccag      840

caagaagagg aucagcugau ggaccaagau cagcacaacc auuaagacca gaagauggac      900

auuguucaug gccauuauaa ggacuagugc aucacauuua aaagcaucuc agccuaccau      960

gagaauaaga gaaagaaaau gaagaucaau agcuuauuca ucucuuuuuc uuuuucguug     1020

guguaaagcc aacacccugu cuaaaaaaca uaaauuucuu uaaucauuuu gccucuuuuc     1080

ucugugcuuc aauuaauaaa aaauggaaag aaccuagauc uaaaaaaaaa aaaaaaaaaa     1140

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaugcau cccccccccc     1200

cccccccccc cccccccccc caaaggcucu uuucagagcc accagaauu                 1249


<210>  354
<211>  832
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  PDCD1(1-149) mRNA product TOP UTR opt6

<400>  354
ggggcgcugc cuacggaggu ggcagccauc uccuucucgg caucaagcuu accaugcaaa       60

uaccacaagc accauggcca guaguauggg cuguacuaca auuagguugg cgaccaggau      120

gguuuuuaga cucaccagau cguccaugga acccaccaac auuuucacca gcauuauuag      180

uaguaacaga aggagauaau gcaaccuuua cauguucauu caguaacaca ucagaaaguu      240

uuguacuaaa uugguauaga augucaccuu caaaucaaac agauaaauua gcagcauuuc      300

cagaagauag aucacaacca ggacaagauu gcagauuuag aguaacacaa uuaccuaaug      360

gacgagacuu ucauauguca guaguaagag cucgacguaa cgauucagga acauacuuau      420

guggagcaau aucauuagca ccaaaagcac aaauaaaaga aucuuuaaga gcagaauuaa      480

gaguaacaga aagacgcgca uaaggacuag ugcaucacau uuaaaagcau cucagccuac      540

caugagaaua agagaaagaa aaugaagauc aauagcuuau ucaucucuuu uucuuuuucg      600

uugguguaaa gccaacaccc ugucuaaaaa acauaaauuu cuuuaaucau uuugccucuu      660

uucucugugc uucaauuaau aaaaaaugga aagaaccuag aucuaaaaaa aaaaaaaaaa      720

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaug cauccccccc      780

cccccccccc cccccccccc ccccaaaggc ucuuuucaga gccaccagaa uu              832


<210>  355
<211>  1042
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  IL12A mRNA product TOP UTR opt6

<400>  355
ggggcgcugc cuacggaggu ggcagccauc uccuucucgg caucaagcuu accaugugcc       60

cagcaagauc acuacuacug guagcaacac ugguacuacu agaccaccua ucacucgcca      120

gaaaccuccc aguagccaca ccagacccag gaauguuccc cugccuccac cauucccaaa      180

accuacuaag agcaguauca aacaugcuac aaaaagcaag acaaacacua gaguucuauc      240

caugcacauc agaagaaaua gaccacgaag acauaacaaa agacaaaaca ucaaccguag      300

aagcaugccu cccacucgaa cucacaaaaa acgaaucaug ccuaaacuca agagaaacau      360

cauucauaac aaacggcuca ugcuuagccu caagaaaaac aucauucaug auggcacuau      420

gccucucauc cauauaugaa gacuuaaaaa uguaccaagu agaauuuaaa accaugaacg      480

caaaauuacu aauggaccca aaaagacaaa uauuccuaga ccaaaacaug cuagcaguaa      540

uagacgaacu aaugcaagca cuaaacuuca acucagaaac cguaccccaa aaaucaucuc      600

uagaagaacc agacuucuac aaaacaaaaa uaaaacuaug cauacuacua cacgccuuca      660

gaauaagagc cgucacaaua gacagaguca ugucauaccu aaacgccuca uaaggacuag      720

ugcaucacau uuaaaagcau cucagccuac caugagaaua agagaaagaa aaugaagauc      780

aauagcuuau ucaucucuuu uucuuuuucg uugguguaaa gccaacaccc ugucuaaaaa      840

acauaaauuu cuuuaaucau uuugccucuu uucucugugc uucaauuaau aaaaaaugga      900

aagaaccuag aucuaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa      960

aaaaaaaaaa aaaaaaaaug cauccccccc cccccccccc cccccccccc ccccaaaggc     1020

ucuuuucaga gccaccagaa uu                                              1042


<210>  356
<211>  1039
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  IL12A(1-219) mRNA product TOP UTR opt6

<400>  356
ggggcgcugc cuacggaggu ggcagccauc uccuucucgg caucaagcuu accaugugcc       60

cagcaagauc acuacuacug guagcaacac ugguacuacu agaccaccua ucacucgcca      120

gaaaccuccc aguagccaca ccagacccag gaauguuccc cugccuccac cauucccaaa      180

accuacuaag agcaguauca aacaugcuac aaaaagcaag acaaacacua gaguucuauc      240

caugcacauc agaagaaaua gaccacgaag acauaacaaa agacaaaaca ucaaccguag      300

aagcaugccu cccacucgaa cucacaaaaa acgaaucaug ccuaaacuca agagaaacau      360

cauucauaac aaacggcuca ugcuuagccu caagaaaaac aucauucaug auggcacuau      420

gccucucauc cauauaugaa gacuuaaaaa uguaccaagu agaauuuaaa accaugaacg      480

caaaauuacu aauggaccca aaaagacaaa uauuccuaga ccaaaacaug cuagcaguaa      540

uagacgaacu aaugcaagca cuaaacuuca acucagaaac cguaccccaa aaaucaucuc      600

uagaagaacc agacuucuac aaaacaaaaa uaaaacuaug cauacuacua cacgccuuca      660

gaauaagagc cgucacaaua gacagaguca ugucauaccu aaacgccuca ggacuagugc      720

aucacauuua aaagcaucuc agccuaccau gagaauaaga gaaagaaaau gaagaucaau      780

agcuuauuca ucucuuuuuc uuuuucguug guguaaagcc aacacccugu cuaaaaaaca      840

uaaauuucuu uaaucauuuu gccucuuuuc ucugugcuuc aauuaauaaa aaauggaaag      900

aaccuagauc uaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa      960

aaaaaaaaaa aaaaaugcau cccccccccc cccccccccc cccccccccc caaaggcucu     1020

uuucagagcc accagaauu                                                  1039


<210>  357
<211>  976
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  IL12A(23-219) mRNA product TOP UTR opt6

<400>  357
ggggcgcugc cuacggaggu ggcagccauc uccuucucgg caucaagcuu accagaaacc       60

ucccaguagc cacaccagac ccaggaaugu uccccugccu ccaccauucc caaaaccuac      120

uaagagcagu aucaaacaug cuacaaaaag caagacaaac acuagaguuc uauccaugca      180

caucagaaga aauagaccac gaagacauaa caaaagacaa aacaucaacc guagaagcau      240

gccucccacu cgaacucaca aaaaacgaau caugccuaaa cucaagagaa acaucauuca      300

uaacaaacgg cucaugcuua gccucaagaa aaacaucauu caugauggca cuaugccucu      360

cauccauaua ugaagacuua aaaauguacc aaguagaauu uaaaaccaug aacgcaaaau      420

uacuaaugga cccaaaaaga caaauauucc uagaccaaaa caugcuagca guaauagacg      480

aacuaaugca agcacuaaac uucaacucag aaaccguacc ccaaaaauca ucucuagaag      540

aaccagacuu cuacaaaaca aaaauaaaac uaugcauacu acuacacgcc uucagaauaa      600

gagccgucac aauagacaga gucaugucau accuaaacgc cucauaagga cuagugcauc      660

acauuuaaaa gcaucucagc cuaccaugag aauaagagaa agaaaaugaa gaucaauagc      720

uuauucaucu cuuuuucuuu uucguuggug uaaagccaac acccugucua aaaaacauaa      780

auuucuuuaa ucauuuugcc ucuuuucucu gugcuucaau uaauaaaaaa uggaaagaac      840

cuagaucuaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa      900

aaaaaaaaaa aaugcauccc cccccccccc cccccccccc ccccccccaa aggcucuuuu      960

cagagccacc agaauu                                                      976


<210>  358
<211>  1369
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  IL12B mRNA product TOP UTR opt6

<400>  358
ggggcgcugc cuacggaggu ggcagccauc uccuucucgg caucaagcuu accaugugcc       60

accaacaacu gguaauauca ugguucucac ugguauucuu ggcaucaccc cuaguagcaa      120

uaugggaacu aaaaaaagac guauacguag uagaacuaga cugguaccca gacgcaccag      180

gagaaauggu aguauuaaca ugcgacacac cagaagaaga uggaauaacu uggacauuag      240

accaaucaag ugaaguauua ggaucaggca aaacacuaac uauacaagua aaagaauuug      300

gagacgcagg acaauacacg ugccacaaag gaggcgaagu ccuaucacau ucacuacuau      360

uauuacacaa aaaagaagac ggaaucugga gcacagacau auuaaaagac caaaaagaac      420

caaaaaacaa aacauuucua agaugcgaag cuaaaaacua uucaggaaga uucacaugcu      480

gguggcuaac aaccaucagu accgacuuaa cauucucagu aaaaucauca agaggaucau      540

cagacccaca aggaguaaca uguggagcag caacacuaag cgcagaaaga guacgaggag      600

acaacaaaga auacgaauau ucaguagaau gucaagaaga cucagcaugc ccugcagcag      660

aagaaucauu accaauagaa guaauggucg acgcuguaca caaacuaaaa uaugaaaauu      720

acacaagcag uuucuucaua agagacauaa uaaaacccga cccaccaaaa aaccuacaac      780

uaaaaccauu aaaaaauuca agacaaguag aaguaucaug ggaauaccca gauacaugga      840

gcacaccaca caguuacuuc ucauuaacau ucugcguaca aguacaagga aaaaguaaaa      900

gagaaaaaaa agacagagua uucacagaua agacuucagc aacaguaaua ugcagaaaaa      960

acgcaagcau aagcguacga gcacaagaca gauauuacuc aagcucaugg ucagaauggg     1020

caucaguacc auguucauaa ggacuagugc aucacauuua aaagcaucuc agccuaccau     1080

gagaauaaga gaaagaaaau gaagaucaau agcuuauuca ucucuuuuuc uuuuucguug     1140

guguaaagcc aacacccugu cuaaaaaaca uaaauuucuu uaaucauuuu gccucuuuuc     1200

ucugugcuuc aauuaauaaa aaauggaaag aaccuagauc uaaaaaaaaa aaaaaaaaaa     1260

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaugcau cccccccccc     1320

cccccccccc cccccccccc caaaggcucu uuucagagcc accagaauu                 1369


<210>  359
<211>  1366
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  IL12B(1-328) mRNA product TOP UTR opt6

<400>  359
ggggcgcugc cuacggaggu ggcagccauc uccuucucgg caucaagcuu accaugugcc       60

accaacaacu gguaauauca ugguucucac ugguauucuu ggcaucaccc cuaguagcaa      120

uaugggaacu aaaaaaagac guauacguag uagaacuaga cugguaccca gacgcaccag      180

gagaaauggu aguauuaaca ugcgacacac cagaagaaga uggaauaacu uggacauuag      240

accaaucaag ugaaguauua ggaucaggca aaacacuaac uauacaagua aaagaauuug      300

gagacgcagg acaauacacg ugccacaaag gaggcgaagu ccuaucacau ucacuacuau      360

uauuacacaa aaaagaagac ggaaucugga gcacagacau auuaaaagac caaaaagaac      420

caaaaaacaa aacauuucua agaugcgaag cuaaaaacua uucaggaaga uucacaugcu      480

gguggcuaac aaccaucagu accgacuuaa cauucucagu aaaaucauca agaggaucau      540

cagacccaca aggaguaaca uguggagcag caacacuaag cgcagaaaga guacgaggag      600

acaacaaaga auacgaauau ucaguagaau gucaagaaga cucagcaugc ccugcagcag      660

aagaaucauu accaauagaa guaauggucg acgcuguaca caaacuaaaa uaugaaaauu      720

acacaagcag uuucuucaua agagacauaa uaaaacccga cccaccaaaa aaccuacaac      780

uaaaaccauu aaaaaauuca agacaaguag aaguaucaug ggaauaccca gauacaugga      840

gcacaccaca caguuacuuc ucauuaacau ucugcguaca aguacaagga aaaaguaaaa      900

gagaaaaaaa agacagagua uucacagaua agacuucagc aacaguaaua ugcagaaaaa      960

acgcaagcau aagcguacga gcacaagaca gauauuacuc aagcucaugg ucagaauggg     1020

caucaguacc auguucagga cuagugcauc acauuuaaaa gcaucucagc cuaccaugag     1080

aauaagagaa agaaaaugaa gaucaauagc uuauucaucu cuuuuucuuu uucguuggug     1140

uaaagccaac acccugucua aaaaacauaa auuucuuuaa ucauuuugcc ucuuuucucu     1200

gugcuucaau uaauaaaaaa uggaaagaac cuagaucuaa aaaaaaaaaa aaaaaaaaaa     1260

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaugcauccc cccccccccc     1320

cccccccccc ccccccccaa aggcucuuuu cagagccacc agaauu                    1366


<210>  360
<211>  1303
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  IL12B(23-328) mRNA product TOP UTR opt6

<400>  360
ggggcgcugc cuacggaggu ggcagccauc uccuucucgg caucaagcuu accauauggg       60

aacuaaaaaa agacguauac guaguagaac uagacuggua cccagacgca ccaggagaaa      120

ugguaguauu aacaugcgac acaccagaag aagauggaau aacuuggaca uuagaccaau      180

caagugaagu auuaggauca ggcaaaacac uaacuauaca aguaaaagaa uuuggagacg      240

caggacaaua cacgugccac aaaggaggcg aaguccuauc acauucacua cuauuauuac      300

acaaaaaaga agacggaauc uggagcacag acauauuaaa agaccaaaaa gaaccaaaaa      360

acaaaacauu ucuaagaugc gaagcuaaaa acuauucagg aagauucaca ugcugguggc      420

uaacaaccau caguaccgac uuaacauucu caguaaaauc aucaagagga ucaucagacc      480

cacaaggagu aacaugugga gcagcaacac uaagcgcaga aagaguacga ggagacaaca      540

aagaauacga auauucagua gaaugucaag aagacucagc augcccugca gcagaagaau      600

cauuaccaau agaaguaaug gucgacgcug uacacaaacu aaaauaugaa aauuacacaa      660

gcaguuucuu cauaagagac auaauaaaac ccgacccacc aaaaaaccua caacuaaaac      720

cauuaaaaaa uucaagacaa guagaaguau caugggaaua cccagauaca uggagcacac      780

cacacaguua cuucucauua acauucugcg uacaaguaca aggaaaaagu aaaagagaaa      840

aaaaagacag aguauucaca gauaagacuu cagcaacagu aauaugcaga aaaaacgcaa      900

gcauaagcgu acgagcacaa gacagauauu acucaagcuc auggucagaa ugggcaucag      960

uaccauguuc auaaggacua gugcaucaca uuuaaaagca ucucagccua ccaugagaau     1020

aagagaaaga aaaugaagau caauagcuua uucaucucuu uuucuuuuuc guugguguaa     1080

agccaacacc cugucuaaaa aacauaaauu ucuuuaauca uuuugccucu uuucucugug     1140

cuucaauuaa uaaaaaaugg aaagaaccua gaucuaaaaa aaaaaaaaaa aaaaaaaaaa     1200

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaau gcaucccccc cccccccccc     1260

cccccccccc cccccaaagg cucuuuucag agccaccaga auu                       1303


<210>  361
<211>  436
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Linker-sFvCC49-218 mRNA product TOP UTR opt6

<400>  361
ggggcgcugc cuacggaggu ggcagccauc uccuucucgg caucaagcuu accggaagua       60

caaguggaag uggaaaacca ggaaguggag aaggaaguac aaaaggagga cuagugcauc      120

acauuuaaaa gcaucucagc cuaccaugag aauaagagaa agaaaaugaa gaucaauagc      180

uuauucaucu cuuuuucuuu uucguuggug uaaagccaac acccugucua aaaaacauaa      240

auuucuuuaa ucauuuugcc ucuuuucucu gugcuucaau uaauaaaaaa uggaaagaac      300

cuagaucuaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa      360

aaaaaaaaaa aaugcauccc cccccccccc cccccccccc ccccccccaa aggcucuuuu      420

cagagccacc agaauu                                                      436


<210>  362
<211>  2014
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  IL12 mRNA product TOP UTR opt6

<400>  362
ggggcgcugc cuacggaggu ggcagccauc uccuucucgg caucaagcuu accaugugcc       60

accaacaacu gguaauauca ugguucucac ugguauucuu ggcaucaccc cuaguagcaa      120

uaugggaacu aaaaaaagac guauacguag uagaacuaga cugguaccca gacgcaccag      180

gagaaauggu aguauuaaca ugcgacacac cagaagaaga uggaauaacu uggacauuag      240

accaaucaag ugaaguauua ggaucaggca aaacacuaac uauacaagua aaagaauuug      300

gagacgcagg acaauacacg ugccacaaag gaggcgaagu ccuaucacau ucacuacuau      360

uauuacacaa aaaagaagac ggaaucugga gcacagacau auuaaaagac caaaaagaac      420

caaaaaacaa aacauuucua agaugcgaag cuaaaaacua uucaggaaga uucacaugcu      480

gguggcuaac aaccaucagu accgacuuaa cauucucagu aaaaucauca agaggaucau      540

cagacccaca aggaguaaca uguggagcag caacacuaag cgcagaaaga guacgaggag      600

acaacaaaga auacgaauau ucaguagaau gucaagaaga cucagcaugc ccugcagcag      660

aagaaucauu accaauagaa guaauggucg acgcuguaca caaacuaaaa uaugaaaauu      720

acacaagcag uuucuucaua agagacauaa uaaaacccga cccaccaaaa aaccuacaac      780

uaaaaccauu aaaaaauuca agacaaguag aaguaucaug ggaauaccca gauacaugga      840

gcacaccaca caguuacuuc ucauuaacau ucugcguaca aguacaagga aaaaguaaaa      900

gagaaaaaaa agacagagua uucacagaua agacuucagc aacaguaaua ugcagaaaaa      960

acgcaagcau aagcguacga gcacaagaca gauauuacuc aagcucaugg ucagaauggg     1020

caucaguacc auguucagga aguacaagug gaaguggaaa accaggaagu ggagaaggaa     1080

guacaaaagg aagaaaccuc ccaguagcca caccagaccc aggaauguuc cccugccucc     1140

accauuccca aaaccuacua agagcaguau caaacaugcu acaaaaagca agacaaacac     1200

uagaguucua uccaugcaca ucagaagaaa uagaccacga agacauaaca aaagacaaaa     1260

caucaaccgu agaagcaugc cucccacucg aacucacaaa aaacgaauca ugccuaaacu     1320

caagagaaac aucauucaua acaaacggcu caugcuuagc cucaagaaaa acaucauuca     1380

ugauggcacu augccucuca uccauauaug aagacuuaaa aauguaccaa guagaauuua     1440

aaaccaugaa cgcaaaauua cuaauggacc caaaaagaca aauauuccua gaccaaaaca     1500

ugcuagcagu aauagacgaa cuaaugcaag cacuaaacuu caacucagaa accguacccc     1560

aaaaaucauc ucuagaagaa ccagacuucu acaaaacaaa aauaaaacua ugcauacuac     1620

uacacgccuu cagaauaaga gccgucacaa uagacagagu caugucauac cuaaacgccu     1680

cauaaggacu agugcaucac auuuaaaagc aucucagccu accaugagaa uaagagaaag     1740

aaaaugaaga ucaauagcuu auucaucucu uuuucuuuuu cguuggugua aagccaacac     1800

ccugucuaaa aaacauaaau uucuuuaauc auuuugccuc uuuucucugu gcuucaauua     1860

auaaaaaaug gaaagaaccu agaucuaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa     1920

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa ugcauccccc cccccccccc cccccccccc     1980

ccccccaaag gcucuuuuca gagccaccag aauu                                 2014


<210>  363
<211>  1168
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  CD40LG mRNA product TOP UTR opt6

<400>  363
ggggcgcugc cuacggaggu ggcagccauc uccuucucgg caucaagcuu accaugauag       60

aaacauauaa ucaaacaagc ccaagaucag cagcaacagg acuaccaaua ucaaugaaaa      120

uauucaugua ccuacucaca gucuuccuaa uaacacaaau gauaggaucu gcccuauuug      180

caguauaccu acacagaaga cuagauaaaa uagaagacga aagaaaccua caugaagacu      240

ucguauucau gaaaacaaua caaagaugca acaccggaga aagaucccua ucacuacuaa      300

acugcgaaga aauaaaauca caauucgaag gauucguaaa agacauaaug cuaaacaaag      360

aagaaacaaa aaaagaaaac ucuuucgaaa ugcaaaaagg agaccaaaac ccacaaauag      420

cugcacacgu cauaucagaa gcaucaucaa aaacaacauc aguacuucaa ugggcagaaa      480

aaggauacua uacaauguca aacaaucuag uaacccuaga aaacggaaaa caacuaacag      540

uaaaaagaca aggacuauac uauauauacg cacaaguaac auucugcuca aacagagaag      600

caucaucaca agcaccauuc aucgcaucac uaugccuaaa auccccagga agauucgaac      660

gaauccuacu aagagcagca aacacacacu caucagcaaa accaugcggc caacaaucaa      720

uacaccuagg aggaguauuc gaacuacaac caggagcauc aguauucgua aacguaacag      780

accccucaca aguaagccac ggcacaggau ucacaucauu uggacuauua aaauuauaag      840

gacuagugca ucacauuuaa aagcaucuca gccuaccaug agaauaagag aaagaaaaug      900

aagaucaaua gcuuauucau cucuuuuucu uuuucguugg uguaaagcca acacccuguc      960

uaaaaaacau aaauuucuuu aaucauuuug ccucuuuucu cugugcuuca auuaauaaaa     1020

aauggaaaga accuagaucu aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa     1080

aaaaaaaaaa aaaaaaaaaa aaaaugcauc cccccccccc cccccccccc cccccccccc     1140

aaaggcucuu uucagagcca ccagaauu                                        1168


<210>  364
<211>  1249
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  PDCD1 mRNA product TOP UTR opt7

<400>  364
ggggcgcugc cuacggaggu ggcagccauc uccuucucgg caucaagcuu accaugcaga       60

ucccccaagc cccauggccg guggucuggg cagugcugca gcucggcugg aggcccgggu      120

gguuccugga cagcccagau cggcccugga acccacccac cuuuucccca gccuugcugg      180

uagugacuga gggugacaau gcgaccuuca cgugcaguuu uagcaacacu uccgaaaguu      240

ucguccucaa uugguaccgc augagcccgu ccaaccagac cgauaagcug gccgcauuuc      300

ccgaggacag gagccagcca ggccaagauu gucgguuccg cgugacccag uugcccaaug      360

ggagggacuu ucacaugucc gugguccggg cccgcaggaa cgauaguggc acuuaucugu      420

gcggugcaau uagccucgcc ccaaaagcgc agaucaagga aucccugcgg gccgagcugc      480

gcgugaccga aaggcgggca gagguaccca cggcccaucc gagccccagu ccacgccccg      540

ccgggcaguu ccaaacucuc guggucggcg uggugggcgg gcuguugggu ucccuggucc      600

uccuggugug gguacuggca gugauuugua gcagggccgc gcggggcacc aucggggccc      660

gcaggacugg ccagccauug aaagaggacc ccuccgcagu cccaguguuu aguguggauu      720

acggugaacu cgacuuccag uggcgggaga agaccccgga acccccaguc cccugcgugc      780

cagagcagac cgaguaugcc acgauuguau uucccagcgg gaugggcacu uccagcccgg      840

cacgcagggg cagugccgau gggccacggu ccgcccaacc ccugaggccc gaagacgguc      900

acuguagcug gccacuguga ggacuagugc aucacauuua aaagcaucuc agccuaccau      960

gagaauaaga gaaagaaaau gaagaucaau agcuuauuca ucucuuuuuc uuuuucguug     1020

guguaaagcc aacacccugu cuaaaaaaca uaaauuucuu uaaucauuuu gccucuuuuc     1080

ucugugcuuc aauuaauaaa aaauggaaag aaccuagauc uaaaaaaaaa aaaaaaaaaa     1140

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaugcau cccccccccc     1200

cccccccccc cccccccccc caaaggcucu uuucagagcc accagaauu                 1249


<210>  365
<211>  832
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  PDCD1(1-149) mRNA product TOP UTR opt7

<400>  365
ggggcgcugc cuacggaggu ggcagccauc uccuucucgg caucaagcuu accaugcaga       60

ucccccaagc cccauggccg guggucuggg cagugcugca gcucggcugg aggcccgggu      120

gguuccugga cagcccagau cggcccugga acccacccac cuuuucccca gccuugcugg      180

uagugacuga gggugacaau gcgaccuuca cgugcaguuu uagcaacacu uccgaaaguu      240

ucguccucaa uugguaccgc augagcccgu ccaaccagac cgauaagcug gccgcauuuc      300

ccgaggacag gagccagcca ggccaagauu gucgguuccg cgugacccag uugcccaaug      360

ggagggacuu ucacaugucc gugguccggg cccgcaggaa cgauaguggc acuuaucugu      420

gcggugcaau uagccucgcc ccaaaagcgc agaucaagga aucccugcgg gccgagcugc      480

gcgugaccga aaggcgggca ugaggacuag ugcaucacau uuaaaagcau cucagccuac      540

caugagaaua agagaaagaa aaugaagauc aauagcuuau ucaucucuuu uucuuuuucg      600

uugguguaaa gccaacaccc ugucuaaaaa acauaaauuu cuuuaaucau uuugccucuu      660

uucucugugc uucaauuaau aaaaaaugga aagaaccuag aucuaaaaaa aaaaaaaaaa      720

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaug cauccccccc      780

cccccccccc cccccccccc ccccaaaggc ucuuuucaga gccaccagaa uu              832


<210>  366
<211>  1042
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  IL12A mRNA product TOP UTR opt7

<400>  366
ggggcgcugc cuacggaggu ggcagccauc uccuucucgg caucaagcuu accaugugcc       60

ccgccaggag ccugcuccug guggcaaccu ugguccugcu cgaccaccug uccuuggccc      120

ggaaccugcc aguggcgacu ccggaucccg gcauguuccc augucuccau cacagucaga      180

aucugcugcg cgccguaagc aacaugcucc aaaaggcaag gcagacccug gaguuuuacc      240

ccugcacguc cgaagagauc gaccaugaag auauuacuaa agacaagacc aguaccgugg      300

aggccuguuu gccacuggaa cucacuaaaa augagagcug ccugaacucc cgggagacca      360

gcuucaucac gaaugggucc ugucuggcaa gucgcaagac uagcuuuaug auggccuugu      420

gccucuccag cauuuaugaa gaucugaaaa uguaccaggu cgaguucaag accaugaacg      480

cgaagcugcu cauggacccc aaaaggcaga ucuuucugga ucaaaauaug uuggccguga      540

uugacgaacu gaugcaggca cucaacuuca auagugagac ugugccacag aaguccagcc      600

uggaggaacc ggauuuuuau aaaaccaaga ucaaacugug uaucuugcuc cacgccuucc      660

ggauucgcgc cgucaccauc gacaggguga uguccuaccu gaacgcaagu ugaggacuag      720

ugcaucacau uuaaaagcau cucagccuac caugagaaua agagaaagaa aaugaagauc      780

aauagcuuau ucaucucuuu uucuuuuucg uugguguaaa gccaacaccc ugucuaaaaa      840

acauaaauuu cuuuaaucau uuugccucuu uucucugugc uucaauuaau aaaaaaugga      900

aagaaccuag aucuaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa      960

aaaaaaaaaa aaaaaaaaug cauccccccc cccccccccc cccccccccc ccccaaaggc     1020

ucuuuucaga gccaccagaa uu                                              1042


<210>  367
<211>  1039
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  IL12A(1-219) mRNA product TOP UTR opt7

<400>  367
ggggcgcugc cuacggaggu ggcagccauc uccuucucgg caucaagcuu accaugugcc       60

ccgccaggag ccugcuccug guggcaaccu ugguccugcu cgaccaccug uccuuggccc      120

ggaaccugcc aguggcgacu ccggaucccg gcauguuccc augucuccau cacagucaga      180

aucugcugcg cgccguaagc aacaugcucc aaaaggcaag gcagacccug gaguuuuacc      240

ccugcacguc cgaagagauc gaccaugaag auauuacuaa agacaagacc aguaccgugg      300

aggccuguuu gccacuggaa cucacuaaaa augagagcug ccugaacucc cgggagacca      360

gcuucaucac gaaugggucc ugucuggcaa gucgcaagac uagcuuuaug auggccuugu      420

gccucuccag cauuuaugaa gaucugaaaa uguaccaggu cgaguucaag accaugaacg      480

cgaagcugcu cauggacccc aaaaggcaga ucuuucugga ucaaaauaug uuggccguga      540

uugacgaacu gaugcaggca cucaacuuca auagugagac ugugccacag aaguccagcc      600

uggaggaacc ggauuuuuau aaaaccaaga ucaaacugug uaucuugcuc cacgccuucc      660

ggauucgcgc cgucaccauc gacaggguga uguccuaccu gaacgcaagu ggacuagugc      720

aucacauuua aaagcaucuc agccuaccau gagaauaaga gaaagaaaau gaagaucaau      780

agcuuauuca ucucuuuuuc uuuuucguug guguaaagcc aacacccugu cuaaaaaaca      840

uaaauuucuu uaaucauuuu gccucuuuuc ucugugcuuc aauuaauaaa aaauggaaag      900

aaccuagauc uaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa      960

aaaaaaaaaa aaaaaugcau cccccccccc cccccccccc cccccccccc caaaggcucu     1020

uuucagagcc accagaauu                                                  1039


<210>  368
<211>  976
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  IL12A(23-219) mRNA product TOP UTR opt7

<400>  368
ggggcgcugc cuacggaggu ggcagccauc uccuucucgg caucaagcuu acccggaacc       60

ugccaguggc gacuccggau cccggcaugu ucccaugucu ccaucacagu cagaaucugc      120

ugcgcgccgu aagcaacaug cuccaaaagg caaggcagac ccuggaguuu uaccccugca      180

cguccgaaga gaucgaccau gaagauauua cuaaagacaa gaccaguacc guggaggccu      240

guuugccacu ggaacucacu aaaaaugaga gcugccugaa cucccgggag accagcuuca      300

ucacgaaugg guccugucug gcaagucgca agacuagcuu uaugauggcc uugugccucu      360

ccagcauuua ugaagaucug aaaauguacc aggucgaguu caagaccaug aacgcgaagc      420

ugcucaugga ccccaaaagg cagaucuuuc uggaucaaaa uauguuggcc gugauugacg      480

aacugaugca ggcacucaac uucaauagug agacugugcc acagaagucc agccuggagg      540

aaccggauuu uuauaaaacc aagaucaaac uguguaucuu gcuccacgcc uuccggauuc      600

gcgccgucac caucgacagg gugauguccu accugaacgc aaguugagga cuagugcauc      660

acauuuaaaa gcaucucagc cuaccaugag aauaagagaa agaaaaugaa gaucaauagc      720

uuauucaucu cuuuuucuuu uucguuggug uaaagccaac acccugucua aaaaacauaa      780

auuucuuuaa ucauuuugcc ucuuuucucu gugcuucaau uaauaaaaaa uggaaagaac      840

cuagaucuaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa      900

aaaaaaaaaa aaugcauccc cccccccccc cccccccccc ccccccccaa aggcucuuuu      960

cagagccacc agaauu                                                      976


<210>  369
<211>  1369
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  IL12B mRNA product TOP UTR opt7

<400>  369
ggggcgcugc cuacggaggu ggcagccauc uccuucucgg caucaagcuu accaugugcc       60

accagcaacu ggugaucagc ugguucuccc ucgucuuucu ggccaguccc uugguggcaa      120

uuugggagcu gaagaaagac guauacgugg ucgaacucga uugguaucca gacgccccgg      180

gcgagauggu ggugcugacc ugugauacuc ccgaagagga cgggaucacc uggacguugg      240

aucagagcuc cgaaguccug gguaguggca agacucucac cauucaggug aaagaguucg      300

gggacgcggg ccaguauacc ugccauaagg guggggaggu acugagccac ucccugcucc      360

uguugcauaa aaaggaagau ggcaucugga gcacugacau ucugaaggau caaaaagagc      420

caaagaacaa aaccuuucuc aggugugaag ccaagaauua cuccggccgg uucacgugcu      480

gguggcugac uaccaucagu acugaccuga ccuuuagcgu gaaauccagc cgcgggaguu      540

ccgaucccca gggugucacc uguggcgcag ccacguugag cgcagagagg gugcgcgggg      600

acaacaagga guacgaauau uccguggagu gccaggaaga uagugccugu ccagcggccg      660

aggaaagccu ccccaucgag gucauggugg acgcaguaca caaacugaag uacgagaauu      720

auacuuccag cuucuuuauu cgggacauca uuaagccaga uccgcccaaa aaccugcagc      780

ucaagccacu gaaaaauagu aggcaagugg aagucuccug ggaguacccc gacaccugga      840

gcacuccaca uaguuacuuc uccuugaccu uuugcgucca ggugcagggc aagagcaaac      900

gggaaaagaa ggaucgcgug uucaccgaca aaacuagcgc cacggugauc uguaggaaga      960

acgccuccau uaguguacgg gcacaggauc gcuauuacag cuccagcugg agugaguggg     1020

ccuccgugcc cugcagcuga ggacuagugc aucacauuua aaagcaucuc agccuaccau     1080

gagaauaaga gaaagaaaau gaagaucaau agcuuauuca ucucuuuuuc uuuuucguug     1140

guguaaagcc aacacccugu cuaaaaaaca uaaauuucuu uaaucauuuu gccucuuuuc     1200

ucugugcuuc aauuaauaaa aaauggaaag aaccuagauc uaaaaaaaaa aaaaaaaaaa     1260

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaugcau cccccccccc     1320

cccccccccc cccccccccc caaaggcucu uuucagagcc accagaauu                 1369


<210>  370
<211>  1366
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  IL12B(1-328) mRNA product TOP UTR opt7

<400>  370
ggggcgcugc cuacggaggu ggcagccauc uccuucucgg caucaagcuu accaugugcc       60

accagcaacu ggugaucagc ugguucuccc ucgucuuucu ggccaguccc uugguggcaa      120

uuugggagcu gaagaaagac guauacgugg ucgaacucga uugguaucca gacgccccgg      180

gcgagauggu ggugcugacc ugugauacuc ccgaagagga cgggaucacc uggacguugg      240

aucagagcuc cgaaguccug gguaguggca agacucucac cauucaggug aaagaguucg      300

gggacgcggg ccaguauacc ugccauaagg guggggaggu acugagccac ucccugcucc      360

uguugcauaa aaaggaagau ggcaucugga gcacugacau ucugaaggau caaaaagagc      420

caaagaacaa aaccuuucuc aggugugaag ccaagaauua cuccggccgg uucacgugcu      480

gguggcugac uaccaucagu acugaccuga ccuuuagcgu gaaauccagc cgcgggaguu      540

ccgaucccca gggugucacc uguggcgcag ccacguugag cgcagagagg gugcgcgggg      600

acaacaagga guacgaauau uccguggagu gccaggaaga uagugccugu ccagcggccg      660

aggaaagccu ccccaucgag gucauggugg acgcaguaca caaacugaag uacgagaauu      720

auacuuccag cuucuuuauu cgggacauca uuaagccaga uccgcccaaa aaccugcagc      780

ucaagccacu gaaaaauagu aggcaagugg aagucuccug ggaguacccc gacaccugga      840

gcacuccaca uaguuacuuc uccuugaccu uuugcgucca ggugcagggc aagagcaaac      900

gggaaaagaa ggaucgcgug uucaccgaca aaacuagcgc cacggugauc uguaggaaga      960

acgccuccau uaguguacgg gcacaggauc gcuauuacag cuccagcugg agugaguggg     1020

ccuccgugcc cugcagcgga cuagugcauc acauuuaaaa gcaucucagc cuaccaugag     1080

aauaagagaa agaaaaugaa gaucaauagc uuauucaucu cuuuuucuuu uucguuggug     1140

uaaagccaac acccugucua aaaaacauaa auuucuuuaa ucauuuugcc ucuuuucucu     1200

gugcuucaau uaauaaaaaa uggaaagaac cuagaucuaa aaaaaaaaaa aaaaaaaaaa     1260

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaugcauccc cccccccccc     1320

cccccccccc ccccccccaa aggcucuuuu cagagccacc agaauu                    1366


<210>  371
<211>  1303
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  IL12B(23-328) mRNA product TOP UTR opt7

<400>  371
ggggcgcugc cuacggaggu ggcagccauc uccuucucgg caucaagcuu accauuuggg       60

agcugaagaa agacguauac guggucgaac ucgauuggua uccagacgcc ccgggcgaga      120

ugguggugcu gaccugugau acucccgaag aggacgggau caccuggacg uuggaucaga      180

gcuccgaagu ccuggguagu ggcaagacuc ucaccauuca ggugaaagag uucggggacg      240

cgggccagua uaccugccau aagggugggg agguacugag ccacucccug cuccuguugc      300

auaaaaagga agauggcauc uggagcacug acauucugaa ggaucaaaaa gagccaaaga      360

acaaaaccuu ucucaggugu gaagccaaga auuacuccgg ccgguucacg ugcugguggc      420

ugacuaccau caguacugac cugaccuuua gcgugaaauc cagccgcggg aguuccgauc      480

cccagggugu caccuguggc gcagccacgu ugagcgcaga gagggugcgc ggggacaaca      540

aggaguacga auauuccgug gagugccagg aagauagugc cuguccagcg gccgaggaaa      600

gccuccccau cgaggucaug guggacgcag uacacaaacu gaaguacgag aauuauacuu      660

ccagcuucuu uauucgggac aucauuaagc cagauccgcc caaaaaccug cagcucaagc      720

cacugaaaaa uaguaggcaa guggaagucu ccugggagua ccccgacacc uggagcacuc      780

cacauaguua cuucuccuug accuuuugcg uccaggugca gggcaagagc aaacgggaaa      840

agaaggaucg cguguucacc gacaaaacua gcgccacggu gaucuguagg aagaacgccu      900

ccauuagugu acgggcacag gaucgcuauu acagcuccag cuggagugag ugggccuccg      960

ugcccugcag cugaggacua gugcaucaca uuuaaaagca ucucagccua ccaugagaau     1020

aagagaaaga aaaugaagau caauagcuua uucaucucuu uuucuuuuuc guugguguaa     1080

agccaacacc cugucuaaaa aacauaaauu ucuuuaauca uuuugccucu uuucucugug     1140

cuucaauuaa uaaaaaaugg aaagaaccua gaucuaaaaa aaaaaaaaaa aaaaaaaaaa     1200

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaau gcaucccccc cccccccccc     1260

cccccccccc cccccaaagg cucuuuucag agccaccaga auu                       1303


<210>  372
<211>  436
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Linker-sFvCC49-218 mRNA product TOP UTR opt7

<400>  372
ggggcgcugc cuacggaggu ggcagccauc uccuucucgg caucaagcuu accggcagca       60

ccuccgggag ugguaagccc ggcagcgggg agggcuccac uaaaggugga cuagugcauc      120

acauuuaaaa gcaucucagc cuaccaugag aauaagagaa agaaaaugaa gaucaauagc      180

uuauucaucu cuuuuucuuu uucguuggug uaaagccaac acccugucua aaaaacauaa      240

auuucuuuaa ucauuuugcc ucuuuucucu gugcuucaau uaauaaaaaa uggaaagaac      300

cuagaucuaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa      360

aaaaaaaaaa aaugcauccc cccccccccc cccccccccc ccccccccaa aggcucuuuu      420

cagagccacc agaauu                                                      436


<210>  373
<211>  2014
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  IL12 mRNA product TOP UTR opt7

<400>  373
ggggcgcugc cuacggaggu ggcagccauc uccuucucgg caucaagcuu accaugugcc       60

accagcaacu ggugaucagc ugguucuccc ucgucuuucu ggccaguccc uugguggcaa      120

uuugggagcu gaagaaagac guauacgugg ucgaacucga uugguaucca gacgccccgg      180

gcgagauggu ggugcugacc ugugauacuc ccgaagagga cgggaucacc uggacguugg      240

aucagagcuc cgaaguccug gguaguggca agacucucac cauucaggug aaagaguucg      300

gggacgcggg ccaguauacc ugccauaagg guggggaggu acugagccac ucccugcucc      360

uguugcauaa aaaggaagau ggcaucugga gcacugacau ucugaaggau caaaaagagc      420

caaagaacaa aaccuuucuc aggugugaag ccaagaauua cuccggccgg uucacgugcu      480

gguggcugac uaccaucagu acugaccuga ccuuuagcgu gaaauccagc cgcgggaguu      540

ccgaucccca gggugucacc uguggcgcag ccacguugag cgcagagagg gugcgcgggg      600

acaacaagga guacgaauau uccguggagu gccaggaaga uagugccugu ccagcggccg      660

aggaaagccu ccccaucgag gucauggugg acgcaguaca caaacugaag uacgagaauu      720

auacuuccag cuucuuuauu cgggacauca uuaagccaga uccgcccaaa aaccugcagc      780

ucaagccacu gaaaaauagu aggcaagugg aagucuccug ggaguacccc gacaccugga      840

gcacuccaca uaguuacuuc uccuugaccu uuugcgucca ggugcagggc aagagcaaac      900

gggaaaagaa ggaucgcgug uucaccgaca aaacuagcgc cacggugauc uguaggaaga      960

acgccuccau uaguguacgg gcacaggauc gcuauuacag cuccagcugg agugaguggg     1020

ccuccgugcc cugcagcggc agcaccuccg ggagugguaa gcccggcagc ggggagggcu     1080

ccacuaaagg ucggaaccug ccaguggcga cuccggaucc cggcauguuc ccaugucucc     1140

aucacaguca gaaucugcug cgcgccguaa gcaacaugcu ccaaaaggca aggcagaccc     1200

uggaguuuua ccccugcacg uccgaagaga ucgaccauga agauauuacu aaagacaaga     1260

ccaguaccgu ggaggccugu uugccacugg aacucacuaa aaaugagagc ugccugaacu     1320

cccgggagac cagcuucauc acgaaugggu ccugucuggc aagucgcaag acuagcuuua     1380

ugauggccuu gugccucucc agcauuuaug aagaucugaa aauguaccag gucgaguuca     1440

agaccaugaa cgcgaagcug cucauggacc ccaaaaggca gaucuuucug gaucaaaaua     1500

uguuggccgu gauugacgaa cugaugcagg cacucaacuu caauagugag acugugccac     1560

agaaguccag ccuggaggaa ccggauuuuu auaaaaccaa gaucaaacug uguaucuugc     1620

uccacgccuu ccggauucgc gccgucacca ucgacagggu gauguccuac cugaacgcaa     1680

guugaggacu agugcaucac auuuaaaagc aucucagccu accaugagaa uaagagaaag     1740

aaaaugaaga ucaauagcuu auucaucucu uuuucuuuuu cguuggugua aagccaacac     1800

ccugucuaaa aaacauaaau uucuuuaauc auuuugccuc uuuucucugu gcuucaauua     1860

auaaaaaaug gaaagaaccu agaucuaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa     1920

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa ugcauccccc cccccccccc cccccccccc     1980

ccccccaaag gcucuuuuca gagccaccag aauu                                 2014


<210>  374
<211>  1168
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  CD40LG mRNA product TOP UTR opt7

<400>  374
ggggcgcugc cuacggaggu ggcagccauc uccuucucgg caucaagcuu accaugaucg       60

agaccuacaa ccagacuagc cccagguccg ccgcaaccgg ccugccaauu aguaugaaga      120

ucuucaugua ucuccugacg guguuuuuga uuacucaaau gaucgggagc gcccuguucg      180

cggucuaccu ccaccggcgc cuggacaaaa uugaagauga gaggaauuug caugaagacu      240

uuguguucau gaagaccauc cagcggugca acaccgguga gcgcucccug agucuccuga      300

auugugaaga gaucaaaagc caguuugagg gcuucguaaa ggauauuaug cugaacaaag      360

aagagacuaa gaaggaaaau uccuuugaga ugcagaaagg ggaccaaaac ccgcagaucg      420

ccgcacacgu gauuagcgag gccuccagua agaccacgag cguccuccag ugggcagaaa      480

aaggcuauua cacuaugucc aauaaccugg ugaccuugga gaaugguaag cagcugacug      540

ugaaaaggca agggcucuau uacaucuaug cccaggucac cuucugcagc aaccgggaag      600

cgaguuccca ggcccccuuu auugcaagcc ugugucugaa guccccaggc cgcuucgaga      660

ggaucuugcu ccgggccgcc aauacccaua guagcgcaaa acccugcggc cagcaaucca      720

uucaccucgg ggguguguuu gaacugcagc caggcgccag cguauucgug aacgucacgg      780

aucccaguca ggugucccau gggacuggcu ucaccagcuu uggucugcug aaguugugag      840

gacuagugca ucacauuuaa aagcaucuca gccuaccaug agaauaagag aaagaaaaug      900

aagaucaaua gcuuauucau cucuuuuucu uuuucguugg uguaaagcca acacccuguc      960

uaaaaaacau aaauuucuuu aaucauuuug ccucuuuucu cugugcuuca auuaauaaaa     1020

aauggaaaga accuagaucu aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa     1080

aaaaaaaaaa aaaaaaaaaa aaaaugcauc cccccccccc cccccccccc cccccccccc     1140

aaaggcucuu uucagagcca ccagaauu                                        1168


<210>  375
<211>  1249
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  PDCD1 mRNA product TOP UTR opt8

<400>  375
ggggcgcugc cuacggaggu ggcagccauc uccuucucgg caucaagcuu accaugcaaa       60

ucccacaagc ccccuggccc guagucuggg ccguacuaca acuaggcugg agacccggcu      120

gguuucucga cagccccgac cgacccugga acccccccac cuucucaccc gcccuccucg      180

ucgucaccga aggcgacaac gccacauuca caugcuccuu cuccaacacc ucugaaucau      240

ucguccuaaa cugguaccga augucacccu ccaaccaaac ugacaaacuc gccgccuuuc      300

ccgaagaccg cucccaaccc ggccaagacu gccgauuccg agucacacaa cuuccuaacg      360

gcagagacuu ccacaugucc guaguccgag cccgccgaaa cgacuccgga accuaccucu      420

gcggagccau cucccucgcc cccaaagccc aaaucaaaga aucccuccga gcagaacucc      480

gcgucaccga acgccgcgcc gaagucccca ccgcacaccc aucacccucc ccccgccccg      540

ccggccaauu ccaaacacuu guaguaggcg ucgucggcgg ccuccuugga ucacucgucc      600

uacuuguaug gguccuagcc gucaucugcu cucgcgccgc acgcggcacc aucggcgcac      660

gacgaaccgg ccaaccucua aaagaagacc ccuccgcagu ccccgucuuc uccgucgacu      720

acggcgaacu cgacuuccaa uggcgcgaaa aaacccccga acccccaguc cccugcguac      780

ccgaacaaac cgaauacgca acaaucguau uccccucagg aaugggcacc ucaucccccg      840

cccgacgagg aucagccgac ggcccacgau ccgcccaacc ccuccgacca gaagacggcc      900

acugcucaug gccccuuuaa ggacuagugc aucacauuua aaagcaucuc agccuaccau      960

gagaauaaga gaaagaaaau gaagaucaau agcuuauuca ucucuuuuuc uuuuucguug     1020

guguaaagcc aacacccugu cuaaaaaaca uaaauuucuu uaaucauuuu gccucuuuuc     1080

ucugugcuuc aauuaauaaa aaauggaaag aaccuagauc uaaaaaaaaa aaaaaaaaaa     1140

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaugcau cccccccccc     1200

cccccccccc cccccccccc caaaggcucu uuucagagcc accagaauu                 1249


<210>  376
<211>  832
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  PDCD1(1-149) mRNA product TOP UTR opt8

<400>  376
ggggcgcugc cuacggaggu ggcagccauc uccuucucgg caucaagcuu accaugcaaa       60

ucccacaagc ccccuggccc guagucuggg ccguacuaca acuaggcugg agacccggcu      120

gguuucucga cagccccgac cgacccugga acccccccac cuucucaccc gcccuccucg      180

ucgucaccga aggcgacaac gccacauuca caugcuccuu cuccaacacc ucugaaucau      240

ucguccuaaa cugguaccga augucacccu ccaaccaaac ugacaaacuc gccgccuuuc      300

ccgaagaccg cucccaaccc ggccaagacu gccgauuccg agucacacaa cuuccuaacg      360

gcagagacuu ccacaugucc guaguccgag cccgccgaaa cgacuccgga accuaccucu      420

gcggagccau cucccucgcc cccaaagccc aaaucaaaga aucccuccga gcagaacucc      480

gcgucaccga acgccgcgcc uaaggacuag ugcaucacau uuaaaagcau cucagccuac      540

caugagaaua agagaaagaa aaugaagauc aauagcuuau ucaucucuuu uucuuuuucg      600

uugguguaaa gccaacaccc ugucuaaaaa acauaaauuu cuuuaaucau uuugccucuu      660

uucucugugc uucaauuaau aaaaaaugga aagaaccuag aucuaaaaaa aaaaaaaaaa      720

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaug cauccccccc      780

cccccccccc cccccccccc ccccaaaggc ucuuuucaga gccaccagaa uu              832


<210>  377
<211>  1042
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  IL12A mRNA product TOP UTR opt8

<400>  377
ggggcgcugc cuacggaggu ggcagccauc uccuucucgg caucaagcuu accaugugcc       60

ccgccagauc ccuccuacuc gucgcaacac uuguccuccu cgaccaccuc ucccucgccc      120

gcaaucuccc cgucgccacc cccgaccccg gaauguuucc cugccuccac cacucacaaa      180

accuccuacg cgccgucuca aacaugcuuc aaaaagcccg acaaacccuc gaauuuuacc      240

ccugcaccuc cgaagaaauc gaccacgaag acauaaccaa agacaaaacc uccaccgucg      300

aagccugccu accauuagaa cuaaccaaaa acgaauccug ccucaacuca cgcgaaaccu      360

ccuucaucac aaacggcuca ugccucgccu cacgcaaaac cuccuucaug auggcccucu      420

gccuaucauc aaucuaugaa gaccucaaaa uguaccaagu agaauuuaaa accaugaacg      480

ccaaacuccu cauggacccc aaacgccaaa ucuuccucga ccaaaacaug cucgcaguca      540

ucgacgaacu caugcaagcc cucaacuuca acucagaaac agucccacaa aaauccuccc      600

ucgaagaacc cgacuucuau aaaaccaaaa ucaaacucug cauccuccuc cacgccuucc      660

gcauacgcgc cguaaccauc gaccgcguaa ugucauaccu aaaugccucu uaaggacuag      720

ugcaucacau uuaaaagcau cucagccuac caugagaaua agagaaagaa aaugaagauc      780

aauagcuuau ucaucucuuu uucuuuuucg uugguguaaa gccaacaccc ugucuaaaaa      840

acauaaauuu cuuuaaucau uuugccucuu uucucugugc uucaauuaau aaaaaaugga      900

aagaaccuag aucuaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa      960

aaaaaaaaaa aaaaaaaaug cauccccccc cccccccccc cccccccccc ccccaaaggc     1020

ucuuuucaga gccaccagaa uu                                              1042


<210>  378
<211>  1039
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  IL12A(1-219) mRNA product TOP UTR opt8

<400>  378
ggggcgcugc cuacggaggu ggcagccauc uccuucucgg caucaagcuu accaugugcc       60

ccgccagauc ccuccuacuc gucgcaacac uuguccuccu cgaccaccuc ucccucgccc      120

gcaaucuccc cgucgccacc cccgaccccg gaauguuucc cugccuccac cacucacaaa      180

accuccuacg cgccgucuca aacaugcuuc aaaaagcccg acaaacccuc gaauuuuacc      240

ccugcaccuc cgaagaaauc gaccacgaag acauaaccaa agacaaaacc uccaccgucg      300

aagccugccu accauuagaa cuaaccaaaa acgaauccug ccucaacuca cgcgaaaccu      360

ccuucaucac aaacggcuca ugccucgccu cacgcaaaac cuccuucaug auggcccucu      420

gccuaucauc aaucuaugaa gaccucaaaa uguaccaagu agaauuuaaa accaugaacg      480

ccaaacuccu cauggacccc aaacgccaaa ucuuccucga ccaaaacaug cucgcaguca      540

ucgacgaacu caugcaagcc cucaacuuca acucagaaac agucccacaa aaauccuccc      600

ucgaagaacc cgacuucuau aaaaccaaaa ucaaacucug cauccuccuc cacgccuucc      660

gcauacgcgc cguaaccauc gaccgcguaa ugucauaccu aaaugccucu ggacuagugc      720

aucacauuua aaagcaucuc agccuaccau gagaauaaga gaaagaaaau gaagaucaau      780

agcuuauuca ucucuuuuuc uuuuucguug guguaaagcc aacacccugu cuaaaaaaca      840

uaaauuucuu uaaucauuuu gccucuuuuc ucugugcuuc aauuaauaaa aaauggaaag      900

aaccuagauc uaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa      960

aaaaaaaaaa aaaaaugcau cccccccccc cccccccccc cccccccccc caaaggcucu     1020

uuucagagcc accagaauu                                                  1039


<210>  379
<211>  976
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  IL12A(23-219) mRNA product TOP UTR opt8

<400>  379
ggggcgcugc cuacggaggu ggcagccauc uccuucucgg caucaagcuu acccgcaauc       60

uccccgucgc cacccccgac cccggaaugu uucccugccu ccaccacuca caaaaccucc      120

uacgcgccgu cucaaacaug cuucaaaaag cccgacaaac ccucgaauuu uaccccugca      180

ccuccgaaga aaucgaccac gaagacauaa ccaaagacaa aaccuccacc gucgaagccu      240

gccuaccauu agaacuaacc aaaaacgaau ccugccucaa cucacgcgaa accuccuuca      300

ucacaaacgg cucaugccuc gccucacgca aaaccuccuu caugauggcc cucugccuau      360

caucaaucua ugaagaccuc aaaauguacc aaguagaauu uaaaaccaug aacgccaaac      420

uccucaugga ccccaaacgc caaaucuucc ucgaccaaaa caugcucgca gucaucgacg      480

aacucaugca agcccucaac uucaacucag aaacaguccc acaaaaaucc ucccucgaag      540

aacccgacuu cuauaaaacc aaaaucaaac ucugcauccu ccuccacgcc uuccgcauac      600

gcgccguaac caucgaccgc guaaugucau accuaaaugc cucuuaagga cuagugcauc      660

acauuuaaaa gcaucucagc cuaccaugag aauaagagaa agaaaaugaa gaucaauagc      720

uuauucaucu cuuuuucuuu uucguuggug uaaagccaac acccugucua aaaaacauaa      780

auuucuuuaa ucauuuugcc ucuuuucucu gugcuucaau uaauaaaaaa uggaaagaac      840

cuagaucuaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa      900

aaaaaaaaaa aaugcauccc cccccccccc cccccccccc ccccccccaa aggcucuuuu      960

cagagccacc agaauu                                                      976


<210>  380
<211>  1369
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  IL12B mRNA product TOP UTR opt8

<400>  380
ggggcgcugc cuacggaggu ggcagccauc uccuucucgg caucaagcuu accaugugcc       60

accaacaacu cgucauaagc ugguucagcc uaguauuccu cgccucaccc cucgucgcca      120

ucugggaacu caagaaagac guauacgucg ucgaacuaga cugguacccc gacgcacccg      180

gagaaauggu aguacucaca ugcgacaccc ccgaagaaga cggcaucaca uggaccuuag      240

accaaucauc agaaguccuc ggauccggaa aaacccucac aauccaaguc aaagaguucg      300

gcgacgccgg ccaauacaca ugccacaaag gcggagaagu ccucucacac ucacuccuuc      360

uacuacacaa gaaagaagac ggcaucuggu ccaccgacau acucaaagac caaaaagaac      420

ccaaaaacaa aaccuuccuc cgcugcgaag ccaaaaacua cuccggccga uucacaugcu      480

gguggcucac caccaucucc accgaccuga ccuucuccgu caaauccagc aggggcuccu      540

cagacccaca aggcguaacc ugcggcgcag ccacccuauc ggccgaacga guccgcggag      600

acaacaaaga auacgaauac agcgucgaau gccaagaaga cucagcaugc ccagcagccg      660

aagaaucacu ccccaucgaa gucauggucg acgccgucca caaacuaaaa uacgaaaacu      720

acacaagcuc auucuucauc cgcgacauaa ucaaacccga cccaccgaaa aaccuccaac      780

ucaaaccccu uaaaaacagc cgccaagucg aagucuccug ggaauacccc gacaccuggu      840

ccacacccca cuccuacuuc ucacucaccu ucugcgucca aguccaaggc aaauccaaac      900

gcgaaaagaa agaccgcgua uucaccgaca aaaccuccgc cacagucauc ugccgcaaaa      960

acgccucaau cuccguccgc gcccaagacc gauacuacag cuccuccugg ucagaauggg     1020

ccuccguccc augcuccuaa ggacuagugc aucacauuua aaagcaucuc agccuaccau     1080

gagaauaaga gaaagaaaau gaagaucaau agcuuauuca ucucuuuuuc uuuuucguug     1140

guguaaagcc aacacccugu cuaaaaaaca uaaauuucuu uaaucauuuu gccucuuuuc     1200

ucugugcuuc aauuaauaaa aaauggaaag aaccuagauc uaaaaaaaaa aaaaaaaaaa     1260

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaugcau cccccccccc     1320

cccccccccc cccccccccc caaaggcucu uuucagagcc accagaauu                 1369


<210>  381
<211>  1366
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  IL12B(1-328) mRNA product TOP UTR opt8

<400>  381
ggggcgcugc cuacggaggu ggcagccauc uccuucucgg caucaagcuu accaugugcc       60

accaacaacu cgucauaagc ugguucagcc uaguauuccu cgccucaccc cucgucgcca      120

ucugggaacu caagaaagac guauacgucg ucgaacuaga cugguacccc gacgcacccg      180

gagaaauggu aguacucaca ugcgacaccc ccgaagaaga cggcaucaca uggaccuuag      240

accaaucauc agaaguccuc ggauccggaa aaacccucac aauccaaguc aaagaguucg      300

gcgacgccgg ccaauacaca ugccacaaag gcggagaagu ccucucacac ucacuccuuc      360

uacuacacaa gaaagaagac ggcaucuggu ccaccgacau acucaaagac caaaaagaac      420

ccaaaaacaa aaccuuccuc cgcugcgaag ccaaaaacua cuccggccga uucacaugcu      480

gguggcucac caccaucucc accgaccuga ccuucuccgu caaauccagc aggggcuccu      540

cagacccaca aggcguaacc ugcggcgcag ccacccuauc ggccgaacga guccgcggag      600

acaacaaaga auacgaauac agcgucgaau gccaagaaga cucagcaugc ccagcagccg      660

aagaaucacu ccccaucgaa gucauggucg acgccgucca caaacuaaaa uacgaaaacu      720

acacaagcuc auucuucauc cgcgacauaa ucaaacccga cccaccgaaa aaccuccaac      780

ucaaaccccu uaaaaacagc cgccaagucg aagucuccug ggaauacccc gacaccuggu      840

ccacacccca cuccuacuuc ucacucaccu ucugcgucca aguccaaggc aaauccaaac      900

gcgaaaagaa agaccgcgua uucaccgaca aaaccuccgc cacagucauc ugccgcaaaa      960

acgccucaau cuccguccgc gcccaagacc gauacuacag cuccuccugg ucagaauggg     1020

ccuccguccc augcuccgga cuagugcauc acauuuaaaa gcaucucagc cuaccaugag     1080

aauaagagaa agaaaaugaa gaucaauagc uuauucaucu cuuuuucuuu uucguuggug     1140

uaaagccaac acccugucua aaaaacauaa auuucuuuaa ucauuuugcc ucuuuucucu     1200

gugcuucaau uaauaaaaaa uggaaagaac cuagaucuaa aaaaaaaaaa aaaaaaaaaa     1260

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaugcauccc cccccccccc     1320

cccccccccc ccccccccaa aggcucuuuu cagagccacc agaauu                    1366


<210>  382
<211>  1303
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  IL12B(23-328) mRNA product TOP UTR opt8

<400>  382
ggggcgcugc cuacggaggu ggcagccauc uccuucucgg caucaagcuu accaucuggg       60

aacucaagaa agacguauac gucgucgaac uagacuggua ccccgacgca cccggagaaa      120

ugguaguacu cacaugcgac acccccgaag aagacggcau cacauggacc uuagaccaau      180

caucagaagu ccucggaucc ggaaaaaccc ucacaaucca agucaaagag uucggcgacg      240

ccggccaaua cacaugccac aaaggcggag aaguccucuc acacucacuc cuucuacuac      300

acaagaaaga agacggcauc ugguccaccg acauacucaa agaccaaaaa gaacccaaaa      360

acaaaaccuu ccuccgcugc gaagccaaaa acuacuccgg ccgauucaca ugcugguggc      420

ucaccaccau cuccaccgac cugaccuucu ccgucaaauc cagcaggggc uccucagacc      480

cacaaggcgu aaccugcggc gcagccaccc uaucggccga acgaguccgc ggagacaaca      540

aagaauacga auacagcguc gaaugccaag aagacucagc augcccagca gccgaagaau      600

cacuccccau cgaagucaug gucgacgccg uccacaaacu aaaauacgaa aacuacacaa      660

gcucauucuu cauccgcgac auaaucaaac ccgacccacc gaaaaaccuc caacucaaac      720

cccuuaaaaa cagccgccaa gucgaagucu ccugggaaua ccccgacacc ugguccacac      780

cccacuccua cuucucacuc accuucugcg uccaagucca aggcaaaucc aaacgcgaaa      840

agaaagaccg cguauucacc gacaaaaccu ccgccacagu caucugccgc aaaaacgccu      900

caaucuccgu ccgcgcccaa gaccgauacu acagcuccuc cuggucagaa ugggccuccg      960

ucccaugcuc cuaaggacua gugcaucaca uuuaaaagca ucucagccua ccaugagaau     1020

aagagaaaga aaaugaagau caauagcuua uucaucucuu uuucuuuuuc guugguguaa     1080

agccaacacc cugucuaaaa aacauaaauu ucuuuaauca uuuugccucu uuucucugug     1140

cuucaauuaa uaaaaaaugg aaagaaccua gaucuaaaaa aaaaaaaaaa aaaaaaaaaa     1200

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaau gcaucccccc cccccccccc     1260

cccccccccc cccccaaagg cucuuuucag agccaccaga auu                       1303


<210>  383
<211>  436
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Linker-sFvCC49-218 mRNA product TOP UTR opt8

<400>  383
ggggcgcugc cuacggaggu ggcagccauc uccuucucgg caucaagcuu accgggagca       60

cgagcgggag cgggaagccg ggaaguggag agggaaguac aaagggagga cuagugcauc      120

acauuuaaaa gcaucucagc cuaccaugag aauaagagaa agaaaaugaa gaucaauagc      180

uuauucaucu cuuuuucuuu uucguuggug uaaagccaac acccugucua aaaaacauaa      240

auuucuuuaa ucauuuugcc ucuuuucucu gugcuucaau uaauaaaaaa uggaaagaac      300

cuagaucuaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa      360

aaaaaaaaaa aaugcauccc cccccccccc cccccccccc ccccccccaa aggcucuuuu      420

cagagccacc agaauu                                                      436


<210>  384
<211>  2014
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  IL12 mRNA product TOP UTR opt8

<400>  384
ggggcgcugc cuacggaggu ggcagccauc uccuucucgg caucaagcuu accaugugcc       60

accaacaacu cgucauaagc ugguucagcc uaguauuccu cgccucaccc cucgucgcca      120

ucugggaacu caagaaagac guauacgucg ucgaacuaga cugguacccc gacgcacccg      180

gagaaauggu aguacucaca ugcgacaccc ccgaagaaga cggcaucaca uggaccuuag      240

accaaucauc agaaguccuc ggauccggaa aaacccucac aauccaaguc aaagaguucg      300

gcgacgccgg ccaauacaca ugccacaaag gcggagaagu ccucucacac ucacuccuuc      360

uacuacacaa gaaagaagac ggcaucuggu ccaccgacau acucaaagac caaaaagaac      420

ccaaaaacaa aaccuuccuc cgcugcgaag ccaaaaacua cuccggccga uucacaugcu      480

gguggcucac caccaucucc accgaccuga ccuucuccgu caaauccagc aggggcuccu      540

cagacccaca aggcguaacc ugcggcgcag ccacccuauc ggccgaacga guccgcggag      600

acaacaaaga auacgaauac agcgucgaau gccaagaaga cucagcaugc ccagcagccg      660

aagaaucacu ccccaucgaa gucauggucg acgccgucca caaacuaaaa uacgaaaacu      720

acacaagcuc auucuucauc cgcgacauaa ucaaacccga cccaccgaaa aaccuccaac      780

ucaaaccccu uaaaaacagc cgccaagucg aagucuccug ggaauacccc gacaccuggu      840

ccacacccca cuccuacuuc ucacucaccu ucugcgucca aguccaaggc aaauccaaac      900

gcgaaaagaa agaccgcgua uucaccgaca aaaccuccgc cacagucauc ugccgcaaaa      960

acgccucaau cuccguccgc gcccaagacc gauacuacag cuccuccugg ucagaauggg     1020

ccuccguccc augcuccggg agcacgagcg ggagcgggaa gccgggaagu ggagagggaa     1080

guacaaaggg acgcaaucuc cccgucgcca cccccgaccc cggaauguuu cccugccucc     1140

accacucaca aaaccuccua cgcgccgucu caaacaugcu ucaaaaagcc cgacaaaccc     1200

ucgaauuuua ccccugcacc uccgaagaaa ucgaccacga agacauaacc aaagacaaaa     1260

ccuccaccgu cgaagccugc cuaccauuag aacuaaccaa aaacgaaucc ugccucaacu     1320

cacgcgaaac cuccuucauc acaaacggcu caugccucgc cucacgcaaa accuccuuca     1380

ugauggcccu cugccuauca ucaaucuaug aagaccucaa aauguaccaa guagaauuua     1440

aaaccaugaa cgccaaacuc cucauggacc ccaaacgcca aaucuuccuc gaccaaaaca     1500

ugcucgcagu caucgacgaa cucaugcaag cccucaacuu caacucagaa acagucccac     1560

aaaaauccuc ccucgaagaa cccgacuucu auaaaaccaa aaucaaacuc ugcauccucc     1620

uccacgccuu ccgcauacgc gccguaacca ucgaccgcgu aaugucauac cuaaaugccu     1680

cuuaaggacu agugcaucac auuuaaaagc aucucagccu accaugagaa uaagagaaag     1740

aaaaugaaga ucaauagcuu auucaucucu uuuucuuuuu cguuggugua aagccaacac     1800

ccugucuaaa aaacauaaau uucuuuaauc auuuugccuc uuuucucugu gcuucaauua     1860

auaaaaaaug gaaagaaccu agaucuaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa     1920

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa ugcauccccc cccccccccc cccccccccc     1980

ccccccaaag gcucuuuuca gagccaccag aauu                                 2014


<210>  385
<211>  1168
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  CD40LG mRNA product TOP UTR opt8

<400>  385
ggggcgcugc cuacggaggu ggcagccauc uccuucucgg caucaagcuu accaugauag       60

aaaccuacaa ccaaaccucu ccccgauccg cagccaccgg ccuccccauc uccaugaaaa      120

ucuucaugua ccuccuaacc gucuuccuaa ucacucaaau gaucggcucc gcucucuucg      180

cagucuaccu ccaccgccgc cuagacaaaa ucgaagacga acgcaaccua cacgaagacu      240

ucgucuucau gaaaaccauu caacgcugca acacaggcga acgaucccua ucccuacuca      300

acugcgaaga aaucaaaucc caauucgaag gcuuuguaaa agacaucaug cucaacaaag      360

aagaaaccaa aaaagaaaac uccuucgaaa ugcaaaaagg cgaccaaaac ccccaaauag      420

ccgcccaugu cauaucagaa gccuccucca aaaccaccuc cguccuccaa ugggccgaaa      480

aaggcuacua caccaugucc aacaaccuag uaacccuuga aaacggcaaa caacucaccg      540

uaaaacgcca aggccucuac uacaucuacg cccaagucac cuucugcucc aacagagaag      600

cauccuccca agcacccuuc aucgccuccc uaugccucaa aucccccggc cgcuucgaac      660

gaauccuccu ccgcgccgcc aacacucacu ccucagccaa acccugcggc caacaaagua      720

uacaccuugg cggagucuuc gaacuccaac ccggcgccuc cgucuucgua aacgucaccg      780

accccucaca agucucccac ggaaccggau ucaccuccuu cggccuacua aaacuauagg      840

gacuagugca ucacauuuaa aagcaucuca gccuaccaug agaauaagag aaagaaaaug      900

aagaucaaua gcuuauucau cucuuuuucu uuuucguugg uguaaagcca acacccuguc      960

uaaaaaacau aaauuucuuu aaucauuuug ccucuuuucu cugugcuuca auuaauaaaa     1020

aauggaaaga accuagaucu aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa     1080

aaaaaaaaaa aaaaaaaaaa aaaaugcauc cccccccccc cccccccccc cccccccccc     1140

aaaggcucuu uucagagcca ccagaauu                                        1168


<210>  386
<211>  1249
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  PDCD1 mRNA product TOP UTR opt9

<400>  386
ggggcgcugc cuacggaggu ggcagccauc uccuucucgg caucaagcuu accaugcaaa       60

ucccccaagc cccauggccc gucgucuggg ccguccucca acucggcugg cgccccggau      120

gguuccuaga cucuccagac cgccccugga auccacccac cuucuccccc gcccuccuag      180

ucgucaccga aggcgacaac gccaccuuca ccuguucauu cuccaacacc ucagaauccu      240

ucguacucaa cugguaccgc auguccccaa gcaaccaaac agacaaacuc gccgccuucc      300

ccgaagaccg cucccaaccc ggucaagacu gccgauuccg cgucacccaa cuccccaacg      360

gacgcgacuu ccacaugucc gucguucgag cacgacgcaa cgacucaggc acauaccuau      420

gcggagccau cucccuagcc cccaaagccc aaaucaaaga aucacuacgc gccgaacucc      480

gcgucaccga acgccgcgcc gaaguaccca cagcccaccc auccccauca ccacgcccag      540

caggucaauu ccaaaccuua gucgucggag ucgucggcgg ccuccuaggc ucacucgucc      600

uccuagucug gguccucgcc gucauaugca gccgcgccgc acgcggcacc aucggcgcca      660

gacgcaccgg acaaccccuc aaagaagacc ccucagccgu ccccgucuuu uccgucgacu      720

acggcgaacu agacuuccaa uggcgcgaaa aaacccccga accccccguc ccaugcguac      780

ccgaacaaac cgaauacgcc acaauagucu ucccauccgg caugggaacc ucaucacccg      840

ccagacgagg cucagcagau ggcccccgcu ccgcacaacc acuccgacca gaagacggcc      900

acugcagcug gccccuguaa ggacuagugc aucacauuua aaagcaucuc agccuaccau      960

gagaauaaga gaaagaaaau gaagaucaau agcuuauuca ucucuuuuuc uuuuucguug     1020

guguaaagcc aacacccugu cuaaaaaaca uaaauuucuu uaaucauuuu gccucuuuuc     1080

ucugugcuuc aauuaauaaa aaauggaaag aaccuagauc uaaaaaaaaa aaaaaaaaaa     1140

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaugcau cccccccccc     1200

cccccccccc cccccccccc caaaggcucu uuucagagcc accagaauu                 1249


<210>  387
<211>  832
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  PDCD1(1-149) mRNA product TOP UTR opt9

<400>  387
ggggcgcugc cuacggaggu ggcagccauc uccuucucgg caucaagcuu accaugcaaa       60

ucccccaagc cccauggccc gucgucuggg ccguccucca acucggcugg cgccccggau      120

gguuccuaga cucuccagac cgccccugga auccacccac cuucuccccc gcccuccuag      180

ucgucaccga aggcgacaac gccaccuuca ccuguucauu cuccaacacc ucagaauccu      240

ucguacucaa cugguaccgc auguccccaa gcaaccaaac agacaaacuc gccgccuucc      300

ccgaagaccg cucccaaccc ggucaagacu gccgauuccg cgucacccaa cuccccaacg      360

gacgcgacuu ccacaugucc gucguucgag cacgacgcaa cgacucaggc acauaccuau      420

gcggagccau cucccuagcc cccaaagccc aaaucaaaga aucacuacgc gccgaacucc      480

gcgucaccga acgccgcgcc uaaggacuag ugcaucacau uuaaaagcau cucagccuac      540

caugagaaua agagaaagaa aaugaagauc aauagcuuau ucaucucuuu uucuuuuucg      600

uugguguaaa gccaacaccc ugucuaaaaa acauaaauuu cuuuaaucau uuugccucuu      660

uucucugugc uucaauuaau aaaaaaugga aagaaccuag aucuaaaaaa aaaaaaaaaa      720

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaug cauccccccc      780

cccccccccc cccccccccc ccccaaaggc ucuuuucaga gccaccagaa uu              832


<210>  388
<211>  1042
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  IL12A mRNA product TOP UTR opt9

<400>  388
ggggcgcugc cuacggaggu ggcagccauc uccuucucgg caucaagcuu accaugugcc       60

ccgccagauc ccuccuccuc gucgcaaccc ucguccuccu cgaccaccuc ucccuagcac      120

guaaccuccc agucgccacc ccagaccccg gaauguuccc cugccuccau cacucccaaa      180

aucuccuccg ugccgucucc aacaugcucc aaaaagcccg ccaaacccuc gaauuuuauc      240

caugcaccuc cgaagaaaua gaccaugaag acaucaccaa agacaaaaca uccaccgucg      300

aagccugccu cccccucgaa cucacaaaaa acgaaucaug ccucaacucc cgcgaaaccu      360

ccuucauaac caacggcuca ugccucgccu cucgcaaaac cucauucaug auggcccucu      420

gccuauccuc uaucuacgaa gaccucaaaa uguaccaagu cgaauuuaaa accaugaacg      480

ccaaacuccu cauggacccc aaacgccaaa ucuuccucga ccaaaacaug cucgcaguca      540

ucgacgaacu caugcaagca cucaacuuca acucagaaac cgucccccaa aaauccuccc      600

ucgaagaacc cgacuucuac aaaacaaaaa uaaaacucug cauccuccuc cacgccuucc      660

gcauccgagc agucaccauc gaucgcguca uguccuaccu aaacgccucc uaaggacuag      720

ugcaucacau uuaaaagcau cucagccuac caugagaaua agagaaagaa aaugaagauc      780

aauagcuuau ucaucucuuu uucuuuuucg uugguguaaa gccaacaccc ugucuaaaaa      840

acauaaauuu cuuuaaucau uuugccucuu uucucugugc uucaauuaau aaaaaaugga      900

aagaaccuag aucuaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa      960

aaaaaaaaaa aaaaaaaaug cauccccccc cccccccccc cccccccccc ccccaaaggc     1020

ucuuuucaga gccaccagaa uu                                              1042


<210>  389
<211>  1039
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  IL12A(1-219) mRNA product TOP UTR opt9

<400>  389
ggggcgcugc cuacggaggu ggcagccauc uccuucucgg caucaagcuu accaugugcc       60

ccgccagauc ccuccuccuc gucgcaaccc ucguccuccu cgaccaccuc ucccuagcac      120

guaaccuccc agucgccacc ccagaccccg gaauguuccc cugccuccau cacucccaaa      180

aucuccuccg ugccgucucc aacaugcucc aaaaagcccg ccaaacccuc gaauuuuauc      240

caugcaccuc cgaagaaaua gaccaugaag acaucaccaa agacaaaaca uccaccgucg      300

aagccugccu cccccucgaa cucacaaaaa acgaaucaug ccucaacucc cgcgaaaccu      360

ccuucauaac caacggcuca ugccucgccu cucgcaaaac cucauucaug auggcccucu      420

gccuauccuc uaucuacgaa gaccucaaaa uguaccaagu cgaauuuaaa accaugaacg      480

ccaaacuccu cauggacccc aaacgccaaa ucuuccucga ccaaaacaug cucgcaguca      540

ucgacgaacu caugcaagca cucaacuuca acucagaaac cgucccccaa aaauccuccc      600

ucgaagaacc cgacuucuac aaaacaaaaa uaaaacucug cauccuccuc cacgccuucc      660

gcauccgagc agucaccauc gaucgcguca uguccuaccu aaacgccucc ggacuagugc      720

aucacauuua aaagcaucuc agccuaccau gagaauaaga gaaagaaaau gaagaucaau      780

agcuuauuca ucucuuuuuc uuuuucguug guguaaagcc aacacccugu cuaaaaaaca      840

uaaauuucuu uaaucauuuu gccucuuuuc ucugugcuuc aauuaauaaa aaauggaaag      900

aaccuagauc uaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa      960

aaaaaaaaaa aaaaaugcau cccccccccc cccccccccc cccccccccc caaaggcucu     1020

uuucagagcc accagaauu                                                  1039


<210>  390
<211>  976
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  IL12A(23-219) mRNA product TOP UTR opt9

<400>  390
ggggcgcugc cuacggaggu ggcagccauc uccuucucgg caucaagcuu acccguaacc       60

ucccagucgc caccccagac cccggaaugu uccccugccu ccaucacucc caaaaucucc      120

uccgugccgu cuccaacaug cuccaaaaag cccgccaaac ccucgaauuu uauccaugca      180

ccuccgaaga aauagaccau gaagacauca ccaaagacaa aacauccacc gucgaagccu      240

gccucccccu cgaacucaca aaaaacgaau caugccucaa cucccgcgaa accuccuuca      300

uaaccaacgg cucaugccuc gccucucgca aaaccucauu caugauggcc cucugccuau      360

ccucuaucua cgaagaccuc aaaauguacc aagucgaauu uaaaaccaug aacgccaaac      420

uccucaugga ccccaaacgc caaaucuucc ucgaccaaaa caugcucgca gucaucgacg      480

aacucaugca agcacucaac uucaacucag aaaccguccc ccaaaaaucc ucccucgaag      540

aacccgacuu cuacaaaaca aaaauaaaac ucugcauccu ccuccacgcc uuccgcaucc      600

gagcagucac caucgaucgc gucauguccu accuaaacgc cuccuaagga cuagugcauc      660

acauuuaaaa gcaucucagc cuaccaugag aauaagagaa agaaaaugaa gaucaauagc      720

uuauucaucu cuuuuucuuu uucguuggug uaaagccaac acccugucua aaaaacauaa      780

auuucuuuaa ucauuuugcc ucuuuucucu gugcuucaau uaauaaaaaa uggaaagaac      840

cuagaucuaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa      900

aaaaaaaaaa aaugcauccc cccccccccc cccccccccc ccccccccaa aggcucuuuu      960

cagagccacc agaauu                                                      976


<210>  391
<211>  1369
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  IL12B mRNA product TOP UTR opt9

<400>  391
ggggcgcugc cuacggaggu ggcagccauc uccuucucgg caucaagcuu accauguguc       60

accaacaacu uguaaucagc ugguucuccc ucgucuuccu cgccucaccc cucgucgcca      120

ucugggaacu caaaaaagac gucuacguag ucgaacucga cugguacccc gacgccccag      180

gagaaauggu cguacucacc ugugacaccc ccgaagaaga cggcaucacc uggacccucg      240

accaauccuc cgaaguccuc gguucaggaa aaacccucac cauccaagua aaagaauuug      300

gcgacgccgg gcaauauacc ugccacaaag gcggcgaggu ccuaucccac ucacuccucc      360

uccuccacaa gaaagaagac ggaaucuggu ccaccgacau ccuuaaagac caaaaagaac      420

caaaaaacaa aacauuccuc cgcugcgaag ccaaaaacua cagcggccgc uucaccuguu      480

gguggcuaac cacaauauca accgacuuaa ccuucagcgu caaauccucc agaggaucca      540

gcgacccaca aggaguuacc ugcggagccg caacacucag cgccgaacga guccgcggag      600

acaacaaaga auacgaauac uccgucgaau gccaagaaga cucagcaugc cccgccgcag      660

aagaaucccu acccaucgaa guaaugguag acgccgucca caaacucaaa uacgaaaacu      720

acaccagcuc cuucuucauc cgagacauca ucaaacccga ccccccaaaa aaccuccaac      780

uaaaaccccu caaaaacagc cgccaaguag aaguauccug ggaauacccc gacaccuggu      840

ccacacccca cuccuacuuc ucgcucacgu ucugcgucca aguccaaggc aaauccaaac      900

gagaaaaaaa agaccgcguc uucaccgaca aaacuuccgc caccgucauc ugccgcaaaa      960

acgccagcau cagcguccgc gcacaagacc gcuacuacuc aagcuccugg uccgaauggg     1020

ccuccguccc augcucauaa ggacuagugc aucacauuua aaagcaucuc agccuaccau     1080

gagaauaaga gaaagaaaau gaagaucaau agcuuauuca ucucuuuuuc uuuuucguug     1140

guguaaagcc aacacccugu cuaaaaaaca uaaauuucuu uaaucauuuu gccucuuuuc     1200

ucugugcuuc aauuaauaaa aaauggaaag aaccuagauc uaaaaaaaaa aaaaaaaaaa     1260

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaugcau cccccccccc     1320

cccccccccc cccccccccc caaaggcucu uuucagagcc accagaauu                 1369


<210>  392
<211>  1366
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  IL12B(1-328) mRNA product TOP UTR opt9

<400>  392
ggggcgcugc cuacggaggu ggcagccauc uccuucucgg caucaagcuu accauguguc       60

accaacaacu uguaaucagc ugguucuccc ucgucuuccu cgccucaccc cucgucgcca      120

ucugggaacu caaaaaagac gucuacguag ucgaacucga cugguacccc gacgccccag      180

gagaaauggu cguacucacc ugugacaccc ccgaagaaga cggcaucacc uggacccucg      240

accaauccuc cgaaguccuc gguucaggaa aaacccucac cauccaagua aaagaauuug      300

gcgacgccgg gcaauauacc ugccacaaag gcggcgaggu ccuaucccac ucacuccucc      360

uccuccacaa gaaagaagac ggaaucuggu ccaccgacau ccuuaaagac caaaaagaac      420

caaaaaacaa aacauuccuc cgcugcgaag ccaaaaacua cagcggccgc uucaccuguu      480

gguggcuaac cacaauauca accgacuuaa ccuucagcgu caaauccucc agaggaucca      540

gcgacccaca aggaguuacc ugcggagccg caacacucag cgccgaacga guccgcggag      600

acaacaaaga auacgaauac uccgucgaau gccaagaaga cucagcaugc cccgccgcag      660

aagaaucccu acccaucgaa guaaugguag acgccgucca caaacucaaa uacgaaaacu      720

acaccagcuc cuucuucauc cgagacauca ucaaacccga ccccccaaaa aaccuccaac      780

uaaaaccccu caaaaacagc cgccaaguag aaguauccug ggaauacccc gacaccuggu      840

ccacacccca cuccuacuuc ucgcucacgu ucugcgucca aguccaaggc aaauccaaac      900

gagaaaaaaa agaccgcguc uucaccgaca aaacuuccgc caccgucauc ugccgcaaaa      960

acgccagcau cagcguccgc gcacaagacc gcuacuacuc aagcuccugg uccgaauggg     1020

ccuccguccc augcucagga cuagugcauc acauuuaaaa gcaucucagc cuaccaugag     1080

aauaagagaa agaaaaugaa gaucaauagc uuauucaucu cuuuuucuuu uucguuggug     1140

uaaagccaac acccugucua aaaaacauaa auuucuuuaa ucauuuugcc ucuuuucucu     1200

gugcuucaau uaauaaaaaa uggaaagaac cuagaucuaa aaaaaaaaaa aaaaaaaaaa     1260

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaugcauccc cccccccccc     1320

cccccccccc ccccccccaa aggcucuuuu cagagccacc agaauu                    1366


<210>  393
<211>  1303
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  IL12B(23-328) mRNA product TOP UTR opt9

<400>  393
ggggcgcugc cuacggaggu ggcagccauc uccuucucgg caucaagcuu accaucuggg       60

aacucaaaaa agacgucuac guagucgaac ucgacuggua ccccgacgcc ccaggagaaa      120

uggucguacu caccugugac acccccgaag aagacggcau caccuggacc cucgaccaau      180

ccuccgaagu ccucgguuca ggaaaaaccc ucaccaucca aguaaaagaa uuuggcgacg      240

ccgggcaaua uaccugccac aaaggcggcg agguccuauc ccacucacuc cuccuccucc      300

acaagaaaga agacggaauc ugguccaccg acauccuuaa agaccaaaaa gaaccaaaaa      360

acaaaacauu ccuccgcugc gaagccaaaa acuacagcgg ccgcuucacc uguugguggc      420

uaaccacaau aucaaccgac uuaaccuuca gcgucaaauc cuccagagga uccagcgacc      480

cacaaggagu uaccugcgga gccgcaacac ucagcgccga acgaguccgc ggagacaaca      540

aagaauacga auacuccguc gaaugccaag aagacucagc augccccgcc gcagaagaau      600

cccuacccau cgaaguaaug guagacgccg uccacaaacu caaauacgaa aacuacacca      660

gcuccuucuu cauccgagac aucaucaaac ccgacccccc aaaaaaccuc caacuaaaac      720

cccucaaaaa cagccgccaa guagaaguau ccugggaaua ccccgacacc ugguccacac      780

cccacuccua cuucucgcuc acguucugcg uccaagucca aggcaaaucc aaacgagaaa      840

aaaaagaccg cgucuucacc gacaaaacuu ccgccaccgu caucugccgc aaaaacgcca      900

gcaucagcgu ccgcgcacaa gaccgcuacu acucaagcuc cugguccgaa ugggccuccg      960

ucccaugcuc auaaggacua gugcaucaca uuuaaaagca ucucagccua ccaugagaau     1020

aagagaaaga aaaugaagau caauagcuua uucaucucuu uuucuuuuuc guugguguaa     1080

agccaacacc cugucuaaaa aacauaaauu ucuuuaauca uuuugccucu uuucucugug     1140

cuucaauuaa uaaaaaaugg aaagaaccua gaucuaaaaa aaaaaaaaaa aaaaaaaaaa     1200

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaau gcaucccccc cccccccccc     1260

cccccccccc cccccaaagg cucuuuucag agccaccaga auu                       1303


<210>  394
<211>  436
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Linker-sFvCC49-218 mRNA product TOP UTR opt9

<400>  394
ggggcgcugc cuacggaggu ggcagccauc uccuucucgg caucaagcuu accgggagua       60

cgagugggag ugggaagccg gggagugggg aggggaguac gaagggggga cuagugcauc      120

acauuuaaaa gcaucucagc cuaccaugag aauaagagaa agaaaaugaa gaucaauagc      180

uuauucaucu cuuuuucuuu uucguuggug uaaagccaac acccugucua aaaaacauaa      240

auuucuuuaa ucauuuugcc ucuuuucucu gugcuucaau uaauaaaaaa uggaaagaac      300

cuagaucuaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa      360

aaaaaaaaaa aaugcauccc cccccccccc cccccccccc ccccccccaa aggcucuuuu      420

cagagccacc agaauu                                                      436


<210>  395
<211>  2014
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  IL12 mRNA product TOP UTR opt9

<400>  395
ggggcgcugc cuacggaggu ggcagccauc uccuucucgg caucaagcuu accauguguc       60

accaacaacu uguaaucagc ugguucuccc ucgucuuccu cgccucaccc cucgucgcca      120

ucugggaacu caaaaaagac gucuacguag ucgaacucga cugguacccc gacgccccag      180

gagaaauggu cguacucacc ugugacaccc ccgaagaaga cggcaucacc uggacccucg      240

accaauccuc cgaaguccuc gguucaggaa aaacccucac cauccaagua aaagaauuug      300

gcgacgccgg gcaauauacc ugccacaaag gcggcgaggu ccuaucccac ucacuccucc      360

uccuccacaa gaaagaagac ggaaucuggu ccaccgacau ccuuaaagac caaaaagaac      420

caaaaaacaa aacauuccuc cgcugcgaag ccaaaaacua cagcggccgc uucaccuguu      480

gguggcuaac cacaauauca accgacuuaa ccuucagcgu caaauccucc agaggaucca      540

gcgacccaca aggaguuacc ugcggagccg caacacucag cgccgaacga guccgcggag      600

acaacaaaga auacgaauac uccgucgaau gccaagaaga cucagcaugc cccgccgcag      660

aagaaucccu acccaucgaa guaaugguag acgccgucca caaacucaaa uacgaaaacu      720

acaccagcuc cuucuucauc cgagacauca ucaaacccga ccccccaaaa aaccuccaac      780

uaaaaccccu caaaaacagc cgccaaguag aaguauccug ggaauacccc gacaccuggu      840

ccacacccca cuccuacuuc ucgcucacgu ucugcgucca aguccaaggc aaauccaaac      900

gagaaaaaaa agaccgcguc uucaccgaca aaacuuccgc caccgucauc ugccgcaaaa      960

acgccagcau cagcguccgc gcacaagacc gcuacuacuc aagcuccugg uccgaauggg     1020

ccuccguccc augcucaggg aguacgagug ggagugggaa gccggggagu ggggagggga     1080

guacgaaggg gcguaaccuc ccagucgcca ccccagaccc cggaauguuc cccugccucc     1140

aucacuccca aaaucuccuc cgugccgucu ccaacaugcu ccaaaaagcc cgccaaaccc     1200

ucgaauuuua uccaugcacc uccgaagaaa uagaccauga agacaucacc aaagacaaaa     1260

cauccaccgu cgaagccugc cucccccucg aacucacaaa aaacgaauca ugccucaacu     1320

cccgcgaaac cuccuucaua accaacggcu caugccucgc cucucgcaaa accucauuca     1380

ugauggcccu cugccuaucc ucuaucuacg aagaccucaa aauguaccaa gucgaauuua     1440

aaaccaugaa cgccaaacuc cucauggacc ccaaacgcca aaucuuccuc gaccaaaaca     1500

ugcucgcagu caucgacgaa cucaugcaag cacucaacuu caacucagaa accguccccc     1560

aaaaauccuc ccucgaagaa cccgacuucu acaaaacaaa aauaaaacuc ugcauccucc     1620

uccacgccuu ccgcauccga gcagucacca ucgaucgcgu cauguccuac cuaaacgccu     1680

ccuaaggacu agugcaucac auuuaaaagc aucucagccu accaugagaa uaagagaaag     1740

aaaaugaaga ucaauagcuu auucaucucu uuuucuuuuu cguuggugua aagccaacac     1800

ccugucuaaa aaacauaaau uucuuuaauc auuuugccuc uuuucucugu gcuucaauua     1860

auaaaaaaug gaaagaaccu agaucuaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa     1920

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa ugcauccccc cccccccccc cccccccccc     1980

ccccccaaag gcucuuuuca gagccaccag aauu                                 2014


<210>  396
<211>  1168
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  CD40LG mRNA product TOP UTR opt9

<400>  396
ggggcgcugc cuacggaggu ggcagccauc uccuucucgg caucaagcuu accaugaucg       60

aaacauacaa ccaaacaucc ccccgcuccg ccgccacagg ccuccccauc uccaugaaaa      120

ucuucaugua ccuccucaca guauuccuca ucacccaaau gaucggcucc gcacucuuug      180

cagucuaucu ccaccgucgc cucgacaaaa ucgaagacga acgcaaccuc cacgaagacu      240

ucgucuucau gaaaaccaua caacgcugca acaccggcga acgcucacuc ucccuacuaa      300

acugcgaaga aaucaaaucc caauucgaag gcuucgucaa agacaucaug cuaaacaaag      360

aagaaacaaa aaaagaaaac uccuucgaaa ugcaaaaagg cgaccaaaac ccccaaauag      420

ccgcccacgu caucuccgaa gccuccucca aaaccaccuc cguccuccaa ugggccgaaa      480

aaggcuacua cacaaugucc aacaaccucg ucacccucga aaacggcaaa caacucaccg      540

ucaaacgcca aggccucuac uacaucuacg cccaaguaac cuucugcucc aaccgcgaag      600

ccucaucuca agcucccuuc aucgccucac ucugccucaa aucacccggc cgcuucgaaa      660

gaauccuccu ccgcgccgca aacacccacu cauccgccaa acccugcggc caacaaucca      720

uacaccucgg cggcguuuuc gagcuccaac cuggcgccuc cgucuucgua aacgucaccg      780

accccucaca agucucccac gguaccggcu ucaccuccuu cggacuccua aaacucuaag      840

gacuagugca ucacauuuaa aagcaucuca gccuaccaug agaauaagag aaagaaaaug      900

aagaucaaua gcuuauucau cucuuuuucu uuuucguugg uguaaagcca acacccuguc      960

uaaaaaacau aaauuucuuu aaucauuuug ccucuuuucu cugugcuuca auuaauaaaa     1020

aauggaaaga accuagaucu aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa     1080

aaaaaaaaaa aaaaaaaaaa aaaaugcauc cccccccccc cccccccccc cccccccccc     1140

aaaggcucuu uucagagcca ccagaauu                                        1168


<210>  397
<211>  1249
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  PDCD1 mRNA product TOP UTR opt10

<400>  397
ggggcgcugc cuacggaggu ggcagccauc uccuucucgg caucaagcuu accaugcaaa       60

ucccccaagc ccccuggccg gucgucuggg ccguccucca acucggcugg cgccccggau      120

gguuccucga cucccccgac cgcccgugga acccccccac cuucuccccc gcccuccuag      180

ucgucaccga aggcgacaac gccaccuuca ccuguuccuu cuccaacacc ucagaauccu      240

ucguccucaa cugguaccgc augucccccu ccaaccaaac cgacaaacuc gccgccuucc      300

ccgaagaccg aucccaaccc ggccaagacu gccgcuuccg cgucacacaa cuucccaacg      360

gacgcgacuu ucacaugucc gucguccgcg cccgccgcaa cgacuccggc accuaccucu      420

gcggcgccau cucccucgcc cccaaagccc aaaucaaaga aucccucaga gccgaacucc      480

gcgucaccga acggcgcgcc gaagucccca cugcccaccc cucccccucc ccccgccccg      540

ccggccaauu ccaaacccuc gucgucggcg uugucggcgg ccuccucggc ucacucgucc      600

uccucgucug gguacucgcc gucaucugcu cccgcgccgc gcgcggcacc aucggcgcgc      660

gccgcaccgg acaaccccua aaagaagacc ccuccgccgu ccccgucuuc uccgucgacu      720

acggcgaacu cgacuuccaa uggcgcgaaa aaaccccgga accccccguc ccgugcgucc      780

ccgaacaaac agaauacgcg accaucgucu ucccguccgg caugggcaca uccucacccg      840

cccgccgagg cuccgccgac ggcccccgau ccgcccaacc ccuacgcccc gaagacggcc      900

acugcuccug gccccucuaa ggacuagugc aucacauuua aaagcaucuc agccuaccau      960

gagaauaaga gaaagaaaau gaagaucaau agcuuauuca ucucuuuuuc uuuuucguug     1020

guguaaagcc aacacccugu cuaaaaaaca uaaauuucuu uaaucauuuu gccucuuuuc     1080

ucugugcuuc aauuaauaaa aaauggaaag aaccuagauc uaaaaaaaaa aaaaaaaaaa     1140

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaugcau cccccccccc     1200

cccccccccc cccccccccc caaaggcucu uuucagagcc accagaauu                 1249


<210>  398
<211>  832
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  PDCD1(1-149) mRNA product TOP UTR opt10

<400>  398
ggggcgcugc cuacggaggu ggcagccauc uccuucucgg caucaagcuu accaugcaaa       60

ucccccaagc ccccuggccg gucgucuggg ccguccucca acucggcugg cgccccggau      120

gguuccucga cucccccgac cgcccgugga acccccccac cuucuccccc gcccuccuag      180

ucgucaccga aggcgacaac gccaccuuca ccuguuccuu cuccaacacc ucagaauccu      240

ucguccucaa cugguaccgc augucccccu ccaaccaaac cgacaaacuc gccgccuucc      300

ccgaagaccg aucccaaccc ggccaagacu gccgcuuccg cgucacacaa cuucccaacg      360

gacgcgacuu ucacaugucc gucguccgcg cccgccgcaa cgacuccggc accuaccucu      420

gcggcgccau cucccucgcc cccaaagccc aaaucaaaga aucccucaga gccgaacucc      480

gcgucaccga acggcgcgcc uaaggacuag ugcaucacau uuaaaagcau cucagccuac      540

caugagaaua agagaaagaa aaugaagauc aauagcuuau ucaucucuuu uucuuuuucg      600

uugguguaaa gccaacaccc ugucuaaaaa acauaaauuu cuuuaaucau uuugccucuu      660

uucucugugc uucaauuaau aaaaaaugga aagaaccuag aucuaaaaaa aaaaaaaaaa      720

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaug cauccccccc      780

cccccccccc cccccccccc ccccaaaggc ucuuuucaga gccaccagaa uu              832


<210>  399
<211>  1042
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  IL12A mRNA product TOP UTR opt10

<400>  399
ggggcgcugc cuacggaggu ggcagccauc uccuucucgg caucaagcuu accaugugcc       60

ccgcccguuc acuccuccuc gucgccaccc ucguccuccu agaccaccuc ucccuggccc      120

gcaaccuccc agucgccacc cccgaccccg gcauguuccc cugccuccac cacucccaaa      180

accuccuccg cgccgucucc aacaugcucc aaaaagcccg ccaaacccuc gaauuuuacc      240

ccugcaccuc cgaagagauc gaccacgaag acaucaccaa agacaaaacc uccacagucg      300

aagccugccu cccccucgaa cucaccaaaa acgaauccug ccuuaacucc cgcgaaaccu      360

ccuucaucac caacggcucc ugccucgccu cccgcaaaac cuccuucaug auggcccucu      420

gccucuccuc caucuacgaa gaccucaaaa uguaccaagu cgaauuuaaa accaugaacg      480

ccaaacuccu cauggacccc aaacgccaaa ucuuccucga ccaaaacaug cucgccguca      540

ucgacgaacu caugcaagcc cucaacuuca acuccgaaac cgucccccaa aaauccuccc      600

ucgaagaacc cgacuucuac aaaaccaaaa ucaaacuuug cauccuccuc cacgcauucc      660

gcauccgcgc cgucaccauc gaccguguca ugagcuaccu aaacgccucc ugaggacuag      720

ugcaucacau uuaaaagcau cucagccuac caugagaaua agagaaagaa aaugaagauc      780

aauagcuuau ucaucucuuu uucuuuuucg uugguguaaa gccaacaccc ugucuaaaaa      840

acauaaauuu cuuuaaucau uuugccucuu uucucugugc uucaauuaau aaaaaaugga      900

aagaaccuag aucuaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa      960

aaaaaaaaaa aaaaaaaaug cauccccccc cccccccccc cccccccccc ccccaaaggc     1020

ucuuuucaga gccaccagaa uu                                              1042


<210>  400
<211>  1039
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  IL12A(1-219) mRNA product TOP UTR opt10

<400>  400
ggggcgcugc cuacggaggu ggcagccauc uccuucucgg caucaagcuu accaugugcc       60

ccgcccguuc acuccuccuc gucgccaccc ucguccuccu agaccaccuc ucccuggccc      120

gcaaccuccc agucgccacc cccgaccccg gcauguuccc cugccuccac cacucccaaa      180

accuccuccg cgccgucucc aacaugcucc aaaaagcccg ccaaacccuc gaauuuuacc      240

ccugcaccuc cgaagagauc gaccacgaag acaucaccaa agacaaaacc uccacagucg      300

aagccugccu cccccucgaa cucaccaaaa acgaauccug ccuuaacucc cgcgaaaccu      360

ccuucaucac caacggcucc ugccucgccu cccgcaaaac cuccuucaug auggcccucu      420

gccucuccuc caucuacgaa gaccucaaaa uguaccaagu cgaauuuaaa accaugaacg      480

ccaaacuccu cauggacccc aaacgccaaa ucuuccucga ccaaaacaug cucgccguca      540

ucgacgaacu caugcaagcc cucaacuuca acuccgaaac cgucccccaa aaauccuccc      600

ucgaagaacc cgacuucuac aaaaccaaaa ucaaacuuug cauccuccuc cacgcauucc      660

gcauccgcgc cgucaccauc gaccguguca ugagcuaccu aaacgccucc ggacuagugc      720

aucacauuua aaagcaucuc agccuaccau gagaauaaga gaaagaaaau gaagaucaau      780

agcuuauuca ucucuuuuuc uuuuucguug guguaaagcc aacacccugu cuaaaaaaca      840

uaaauuucuu uaaucauuuu gccucuuuuc ucugugcuuc aauuaauaaa aaauggaaag      900

aaccuagauc uaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa      960

aaaaaaaaaa aaaaaugcau cccccccccc cccccccccc cccccccccc caaaggcucu     1020

uuucagagcc accagaauu                                                  1039


<210>  401
<211>  976
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  IL12A(23-219) mRNA product TOP UTR opt10

<400>  401
ggggcgcugc cuacggaggu ggcagccauc uccuucucgg caucaagcuu acccgcaacc       60

ucccagucgc cacccccgac cccggcaugu uccccugccu ccaccacucc caaaaccucc      120

uccgcgccgu cuccaacaug cuccaaaaag cccgccaaac ccucgaauuu uaccccugca      180

ccuccgaaga gaucgaccac gaagacauca ccaaagacaa aaccuccaca gucgaagccu      240

gccucccccu cgaacucacc aaaaacgaau ccugccuuaa cucccgcgaa accuccuuca      300

ucaccaacgg cuccugccuc gccucccgca aaaccuccuu caugauggcc cucugccucu      360

ccuccaucua cgaagaccuc aaaauguacc aagucgaauu uaaaaccaug aacgccaaac      420

uccucaugga ccccaaacgc caaaucuucc ucgaccaaaa caugcucgcc gucaucgacg      480

aacucaugca agcccucaac uucaacuccg aaaccguccc ccaaaaaucc ucccucgaag      540

aacccgacuu cuacaaaacc aaaaucaaac uuugcauccu ccuccacgca uuccgcaucc      600

gcgccgucac caucgaccgu gucaugagcu accuaaacgc cuccugagga cuagugcauc      660

acauuuaaaa gcaucucagc cuaccaugag aauaagagaa agaaaaugaa gaucaauagc      720

uuauucaucu cuuuuucuuu uucguuggug uaaagccaac acccugucua aaaaacauaa      780

auuucuuuaa ucauuuugcc ucuuuucucu gugcuucaau uaauaaaaaa uggaaagaac      840

cuagaucuaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa      900

aaaaaaaaaa aaugcauccc cccccccccc cccccccccc ccccccccaa aggcucuuuu      960

cagagccacc agaauu                                                      976


<210>  402
<211>  1369
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  IL12B mRNA product TOP UTR opt10

<400>  402
ggggcgcugc cuacggaggu ggcagccauc uccuucucgg caucaagcuu accaugugcc       60

accaacaacu cgucaucucc ugguucuccc ucgucuuccu agccucccca cucgucgcca      120

ucugggaacu caaaaaagac guauacgucg ucgaacucga cugguacccc gacgccccag      180

gagaaauggu cguccuaacc ugcgacacac ccgaagaaga cgguaucacc uggacccucg      240

accaauccuc cgaaguccua ggcuccggca agacccucac cauccaaguc aaagaauuug      300

gcgacgcagg acaauacacc ugucacaaag gcggcgaagu ccucagccac agccuucucc      360

uacuccauaa aaaagaagac ggcaucuggu ccacugacau ccucaaagac caaaaagaac      420

ccaaaaauaa aaccuuccuc cgcugcgaag ccaaaaacua cuccggccga uucaccuguu      480

gguggcuaac cacaaucagc accgaccuca ccuucucagu caaauccucc cgcggcucau      540

cugaccccca aggcgucaca ugcggcgccg ccacccucuc cgccgaacgc guccgcggcg      600

acaacaaaga auacgaauac uccgucgaau gucaagaaga cuccgccugc cccgccgccg      660

aagaaucacu ccccaucgaa gucauggucg acgcagucca caaacucaaa uacgaaaacu      720

acaccuccuc cuucuucauc cgcgacauaa uaaaacccga cccacccaaa aaccuccaac      780

ucaagccacu caaaaacucc cgacaagucg aagucuccug ggaguacccc gacaccuggu      840

ccacaccaca cuccuacuuc ucccucaccu ucugcgucca aguccaaggc aaauccaaac      900

gcgaaaaaaa agaccgcguu uucacagaca aaaccuccgc cacaguaaua ugccgcaaaa      960

acgccuccau cuccguccgg gcccaagacc gcuacuacuc cuccuccugg uccgaguggg     1020

ccucaguccc cugcagcuaa ggacuagugc aucacauuua aaagcaucuc agccuaccau     1080

gagaauaaga gaaagaaaau gaagaucaau agcuuauuca ucucuuuuuc uuuuucguug     1140

guguaaagcc aacacccugu cuaaaaaaca uaaauuucuu uaaucauuuu gccucuuuuc     1200

ucugugcuuc aauuaauaaa aaauggaaag aaccuagauc uaaaaaaaaa aaaaaaaaaa     1260

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaugcau cccccccccc     1320

cccccccccc cccccccccc caaaggcucu uuucagagcc accagaauu                 1369


<210>  403
<211>  1366
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  IL12B(1-328) mRNA product TOP UTR opt10

<400>  403
ggggcgcugc cuacggaggu ggcagccauc uccuucucgg caucaagcuu accaugugcc       60

accaacaacu cgucaucucc ugguucuccc ucgucuuccu agccucccca cucgucgcca      120

ucugggaacu caaaaaagac guauacgucg ucgaacucga cugguacccc gacgccccag      180

gagaaauggu cguccuaacc ugcgacacac ccgaagaaga cgguaucacc uggacccucg      240

accaauccuc cgaaguccua ggcuccggca agacccucac cauccaaguc aaagaauuug      300

gcgacgcagg acaauacacc ugucacaaag gcggcgaagu ccucagccac agccuucucc      360

uacuccauaa aaaagaagac ggcaucuggu ccacugacau ccucaaagac caaaaagaac      420

ccaaaaauaa aaccuuccuc cgcugcgaag ccaaaaacua cuccggccga uucaccuguu      480

gguggcuaac cacaaucagc accgaccuca ccuucucagu caaauccucc cgcggcucau      540

cugaccccca aggcgucaca ugcggcgccg ccacccucuc cgccgaacgc guccgcggcg      600

acaacaaaga auacgaauac uccgucgaau gucaagaaga cuccgccugc cccgccgccg      660

aagaaucacu ccccaucgaa gucauggucg acgcagucca caaacucaaa uacgaaaacu      720

acaccuccuc cuucuucauc cgcgacauaa uaaaacccga cccacccaaa aaccuccaac      780

ucaagccacu caaaaacucc cgacaagucg aagucuccug ggaguacccc gacaccuggu      840

ccacaccaca cuccuacuuc ucccucaccu ucugcgucca aguccaaggc aaauccaaac      900

gcgaaaaaaa agaccgcguu uucacagaca aaaccuccgc cacaguaaua ugccgcaaaa      960

acgccuccau cuccguccgg gcccaagacc gcuacuacuc cuccuccugg uccgaguggg     1020

ccucaguccc cugcagcgga cuagugcauc acauuuaaaa gcaucucagc cuaccaugag     1080

aauaagagaa agaaaaugaa gaucaauagc uuauucaucu cuuuuucuuu uucguuggug     1140

uaaagccaac acccugucua aaaaacauaa auuucuuuaa ucauuuugcc ucuuuucucu     1200

gugcuucaau uaauaaaaaa uggaaagaac cuagaucuaa aaaaaaaaaa aaaaaaaaaa     1260

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaugcauccc cccccccccc     1320

cccccccccc ccccccccaa aggcucuuuu cagagccacc agaauu                    1366


<210>  404
<211>  1303
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  IL12B(23-328) mRNA product TOP UTR opt10

<400>  404
ggggcgcugc cuacggaggu ggcagccauc uccuucucgg caucaagcuu accaucuggg       60

aacucaaaaa agacguauac gucgucgaac ucgacuggua ccccgacgcc ccaggagaaa      120

uggucguccu aaccugcgac acacccgaag aagacgguau caccuggacc cucgaccaau      180

ccuccgaagu ccuaggcucc ggcaagaccc ucaccaucca agucaaagaa uuuggcgacg      240

caggacaaua caccugucac aaaggcggcg aaguccucag ccacagccuu cuccuacucc      300

auaaaaaaga agacggcauc ugguccacug acauccucaa agaccaaaaa gaacccaaaa      360

auaaaaccuu ccuccgcugc gaagccaaaa acuacuccgg ccgauucacc uguugguggc      420

uaaccacaau cagcaccgac cucaccuucu cagucaaauc cucccgcggc ucaucugacc      480

cccaaggcgu cacaugcggc gccgccaccc ucuccgccga acgcguccgc ggcgacaaca      540

aagaauacga auacuccguc gaaugucaag aagacuccgc cugccccgcc gccgaagaau      600

cacuccccau cgaagucaug gucgacgcag uccacaaacu caaauacgaa aacuacaccu      660

ccuccuucuu cauccgcgac auaauaaaac ccgacccacc caaaaaccuc caacucaagc      720

cacucaaaaa cucccgacaa gucgaagucu ccugggagua ccccgacacc ugguccacac      780

cacacuccua cuucucccuc accuucugcg uccaagucca aggcaaaucc aaacgcgaaa      840

aaaaagaccg cguuuucaca gacaaaaccu ccgccacagu aauaugccgc aaaaacgccu      900

ccaucuccgu ccgggcccaa gaccgcuacu acuccuccuc cugguccgag ugggccucag      960

uccccugcag cuaaggacua gugcaucaca uuuaaaagca ucucagccua ccaugagaau     1020

aagagaaaga aaaugaagau caauagcuua uucaucucuu uuucuuuuuc guugguguaa     1080

agccaacacc cugucuaaaa aacauaaauu ucuuuaauca uuuugccucu uuucucugug     1140

cuucaauuaa uaaaaaaugg aaagaaccua gaucuaaaaa aaaaaaaaaa aaaaaaaaaa     1200

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaau gcaucccccc cccccccccc     1260

cccccccccc cccccaaagg cucuuuucag agccaccaga auu                       1303


<210>  405
<211>  436
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Linker-sFvCC49-218 mRNA product TOP UTR opt10

<400>  405
ggggcgcugc cuacggaggu ggcagccauc uccuucucgg caucaagcuu accgggagua       60

cgagugggag ugggaagccg gggagugggg aggggaguac gaagggggga cuagugcauc      120

acauuuaaaa gcaucucagc cuaccaugag aauaagagaa agaaaaugaa gaucaauagc      180

uuauucaucu cuuuuucuuu uucguuggug uaaagccaac acccugucua aaaaacauaa      240

auuucuuuaa ucauuuugcc ucuuuucucu gugcuucaau uaauaaaaaa uggaaagaac      300

cuagaucuaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa      360

aaaaaaaaaa aaugcauccc cccccccccc cccccccccc ccccccccaa aggcucuuuu      420

cagagccacc agaauu                                                      436


<210>  406
<211>  2014
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  IL12 mRNA product TOP UTR opt10

<400>  406
ggggcgcugc cuacggaggu ggcagccauc uccuucucgg caucaagcuu accaugugcc       60

accaacaacu cgucaucucc ugguucuccc ucgucuuccu agccucccca cucgucgcca      120

ucugggaacu caaaaaagac guauacgucg ucgaacucga cugguacccc gacgccccag      180

gagaaauggu cguccuaacc ugcgacacac ccgaagaaga cgguaucacc uggacccucg      240

accaauccuc cgaaguccua ggcuccggca agacccucac cauccaaguc aaagaauuug      300

gcgacgcagg acaauacacc ugucacaaag gcggcgaagu ccucagccac agccuucucc      360

uacuccauaa aaaagaagac ggcaucuggu ccacugacau ccucaaagac caaaaagaac      420

ccaaaaauaa aaccuuccuc cgcugcgaag ccaaaaacua cuccggccga uucaccuguu      480

gguggcuaac cacaaucagc accgaccuca ccuucucagu caaauccucc cgcggcucau      540

cugaccccca aggcgucaca ugcggcgccg ccacccucuc cgccgaacgc guccgcggcg      600

acaacaaaga auacgaauac uccgucgaau gucaagaaga cuccgccugc cccgccgccg      660

aagaaucacu ccccaucgaa gucauggucg acgcagucca caaacucaaa uacgaaaacu      720

acaccuccuc cuucuucauc cgcgacauaa uaaaacccga cccacccaaa aaccuccaac      780

ucaagccacu caaaaacucc cgacaagucg aagucuccug ggaguacccc gacaccuggu      840

ccacaccaca cuccuacuuc ucccucaccu ucugcgucca aguccaaggc aaauccaaac      900

gcgaaaaaaa agaccgcguu uucacagaca aaaccuccgc cacaguaaua ugccgcaaaa      960

acgccuccau cuccguccgg gcccaagacc gcuacuacuc cuccuccugg uccgaguggg     1020

ccucaguccc cugcagcggg aguacgagug ggagugggaa gccggggagu ggggagggga     1080

guacgaaggg gcgcaaccuc ccagucgcca cccccgaccc cggcauguuc cccugccucc     1140

accacuccca aaaccuccuc cgcgccgucu ccaacaugcu ccaaaaagcc cgccaaaccc     1200

ucgaauuuua ccccugcacc uccgaagaga ucgaccacga agacaucacc aaagacaaaa     1260

ccuccacagu cgaagccugc cucccccucg aacucaccaa aaacgaaucc ugccuuaacu     1320

cccgcgaaac cuccuucauc accaacggcu ccugccucgc cucccgcaaa accuccuuca     1380

ugauggcccu cugccucucc uccaucuacg aagaccucaa aauguaccaa gucgaauuua     1440

aaaccaugaa cgccaaacuc cucauggacc ccaaacgcca aaucuuccuc gaccaaaaca     1500

ugcucgccgu caucgacgaa cucaugcaag cccucaacuu caacuccgaa accguccccc     1560

aaaaauccuc ccucgaagaa cccgacuucu acaaaaccaa aaucaaacuu ugcauccucc     1620

uccacgcauu ccgcauccgc gccgucacca ucgaccgugu caugagcuac cuaaacgccu     1680

ccugaggacu agugcaucac auuuaaaagc aucucagccu accaugagaa uaagagaaag     1740

aaaaugaaga ucaauagcuu auucaucucu uuuucuuuuu cguuggugua aagccaacac     1800

ccugucuaaa aaacauaaau uucuuuaauc auuuugccuc uuuucucugu gcuucaauua     1860

auaaaaaaug gaaagaaccu agaucuaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa     1920

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa ugcauccccc cccccccccc cccccccccc     1980

ccccccaaag gcucuuuuca gagccaccag aauu                                 2014


<210>  407
<211>  1168
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  CD40LG mRNA product TOP UTR opt10

<400>  407
ggggcgcugc cuacggaggu ggcagccauc uccuucucgg caucaagcuu accaugaucg       60

aaaccuacaa ucaaaccucc ccccgcagcg ccgcaacagg ccuccccauc uccaugaaaa      120

ucuucaugua ccuccucacc gucuuccuaa ucacccaaau gaucggcucc gcccuauucg      180

ccgucuaccu ccaccgccgc cucgacaaaa ucgaagacga acgcaaccuc cacgaagacu      240

uugucuucau gaaaacuauc caacgaugca acaccggcga acgaucccua ucccuccuca      300

acugcgaaga aauaaaaucc caauucgaag gauucgucaa agacaucaug cuaaacaaag      360

aagaaaccaa aaaagaaaac uccuucgaaa ugcaaaaagg cgaccaaaac ccccaaaucg      420

cagcccacgu caucucagaa gcaucuucca aaaccaccuc cguccuccaa ugggccgaaa      480

aaggcuacua caccauguca aacaaccucg ucacccucga aaacggcaaa caacucaccg      540

ucaaacgcca aggccucuac uacaucuacg cacaagucac cuucugcucc aaccgcgaag      600

cauccuccca agcccccuuc aucgccuccc ucugccucaa aucccccggc cgcuucgaac      660

gcauccuccu ccgcgccgca aauacccacu ccuccgccaa accaugcggc caacaaucca      720

uccaccucgg cggcgucuuc gaacuccaac ccggcgccuc cgucuucguc aacgucaccg      780

accccuccca aguaucccau ggaaccggcu ucaccuccuu cggccuccuc aaacucuagg      840

gacuagugca ucacauuuaa aagcaucuca gccuaccaug agaauaagag aaagaaaaug      900

aagaucaaua gcuuauucau cucuuuuucu uuuucguugg uguaaagcca acacccuguc      960

uaaaaaacau aaauuucuuu aaucauuuug ccucuuuucu cugugcuuca auuaauaaaa     1020

aauggaaaga accuagaucu aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa     1080

aaaaaaaaaa aaaaaaaaaa aaaaugcauc cccccccccc cccccccccc cccccccccc     1140

aaaggcucuu uucagagcca ccagaauu                                        1168


<210>  408
<211>  42
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  5-UTR of human ribosomal protein Large 32 lacking the 5 terminal 
       oligopyrimidine tract

<400>  408
ggcgctgcct acggaggtgg cagccatctc cttctcggca tc                          42


<210>  409
<211>  42
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  5-UTR of human ribosomal protein Large 32 lacking the 5 terminal 
       oligopyrimidine tract mRNA

<400>  409
ggcgcugccu acggaggugg cagccaucuc cuucucggca uc                          42


<210>  410
<211>  75
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  5-UTR of human mitochondrial ATP synthase subunit alpha lacking 
       the 5 terminal oligopyrimidine tract

<400>  410
gcggctcggc cattttgtcc cagtcagtcc ggaggctgcg gctgcagaag taccgcctgc       60

ggagtaactg caaag                                                        75


<210>  411
<211>  75
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  5-UTR of human mitochondrial ATP synthase subunit alpha lacking 
       the 5 terminal oligopyrimidine tract mRNA

<400>  411
gcggcucggc cauuuugucc cagucagucc ggaggcugcg gcugcagaag uaccgccugc       60

ggaguaacug caaag                                                        75


<210>  412
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  3-UTR of Homo sapiens hemoglobin, alpha 1 (HBA1)

<400>  412
gctggagcct cggtggccat gcttcttgcc ccttgggcct ccccccagcc cctcctcccc       60

ttcctgcacc cgtacccccg tggtctttga ataaagtctg agtgggcggc                 110


<210>  413
<211>  110
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  3-UTR of Homo sapiens hemoglobin, alpha 1 (HBA1) mRNA

<400>  413
gcuggagccu cgguggccau gcuucuugcc ccuugggccu ccccccagcc ccuccucccc       60

uuccugcacc cguacccccg uggucuuuga auaaagucug agugggcggc                 110


<210>  414
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  3-UTR of Homo sapiens hemoglobin, alpha 2 (HBA2)

<400>  414
gctggagcct cggtagccgt tcctcctgcc cgctgggcct cccaacgggc cctcctcccc       60

tccttgcacc ggcccttcct ggtctttgaa taaagtctga gtgggcag                   108


<210>  415
<211>  108
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  3-UTR of Homo sapiens hemoglobin, alpha 2 (HBA2) mRNA

<400>  415
gcuggagccu cgguagccgu uccuccugcc cgcugggccu cccaacgggc ccuccucccc       60

uccuugcacc ggcccuuccu ggucuuugaa uaaagucuga gugggcag                   108


<210>  416
<211>  132
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  3-UTR of Homo sapiens hemoglobin, beta (HBB)

<400>  416
gctcgctttc ttgctgtcca atttctatta aaggttcctt tgttccctaa gtccaactac       60

taaactgggg gatattatga agggccttga gcatctggat tctgcctaat aaaaaacatt      120

tattttcatt gc                                                          132


<210>  417
<211>  132
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  3-UTR of Homo sapiens hemoglobin, beta (HBB) mRNA

<400>  417
gcucgcuuuc uugcugucca auuucuauua aagguuccuu uguucccuaa guccaacuac       60

uaaacugggg gauauuauga agggccuuga gcaucuggau ucugccuaau aaaaaacauu      120

uauuuucauu gc                                                          132


<210>  418
<211>  44
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Center, alpha-complex-binding portion of the 3UTR of an 
       alpha-globin gene (muag)

<400>  418
gcccgatggg cctcccaacg ggccctcctc ccctccttgc accg                        44


<210>  419
<211>  44
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Center, alpha-complex-binding portion of the 3UTR of an 
       alpha-globin gene (muag) mRNA

<400>  419
gcccgauggg ccucccaacg ggcccuccuc cccuccuugc accg                        44


<210>  420
<211>  186
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  3-UTR of human albumin

<400>  420
catcacattt aaaagcatct cagcctacca tgagaataag agaaagaaaa tgaagatcaa       60

aagcttattc atctgttttt ctttttcgtt ggtgtaaagc caacaccctg tctaaaaaac      120

ataaatttct ttaatcattt tgcctctttt ctctgtgctt caattaataa aaaatggaaa      180

gaatct                                                                 186


<210>  421
<211>  186
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  3-UTR of human albumin mRNA

<400>  421
caucacauuu aaaagcaucu cagccuacca ugagaauaag agaaagaaaa ugaagaucaa       60

aagcuuauuc aucuguuuuu cuuuuucguu gguguaaagc caacacccug ucuaaaaaac      120

auaaauuucu uuaaucauuu ugccucuuuu cucugugcuu caauuaauaa aaaauggaaa      180

gaaucu                                                                 186


<210>  422
<211>  186
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  3-UTR albumin7

<400>  422
catcacattt aaaagcatct cagcctacca tgagaataag agaaagaaaa tgaagatcaa       60

tagcttattc atctcttttt ctttttcgtt ggtgtaaagc caacaccctg tctaaaaaac      120

ataaatttct ttaatcattt tgcctctttt ctctgtgctt caattaataa aaaatggaaa      180

gaacct                                                                 186


<210>  423
<211>  186
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  3-UTR albumin7 mRNA

<400>  423
caucacauuu aaaagcaucu cagccuacca ugagaauaag agaaagaaaa ugaagaucaa       60

uagcuuauuc aucucuuuuu cuuuuucguu gguguaaagc caacacccug ucuaaaaaac      120

auaaauuucu uuaaucauuu ugccucuuuu cucugugcuu caauuaauaa aaaauggaaa      180

gaaccu                                                                 186


<210>  424
<211>  187
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  3-UTR ALB7

<400>  424
gcatcacatt taaaagcatc tcagcctacc atgagaataa gagaaagaaa atgaagatca       60

atagcttatt catctctttt tctttttcgt tggtgtaaag ccaacaccct gtctaaaaaa      120

cataaatttc tttaatcatt ttgcctcttt tctctgtgct tcaattaata aaaaatggaa      180

agaacct                                                                187


<210>  425
<211>  187
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  3-UTR ALB7 mRNA

<400>  425
gcaucacauu uaaaagcauc ucagccuacc augagaauaa gagaaagaaa augaagauca       60

auagcuuauu caucucuuuu ucuuuuucgu ugguguaaag ccaacacccu gucuaaaaaa      120

cauaaauuuc uuuaaucauu uugccucuuu ucucugugcu ucaauuaaua aaaaauggaa      180

agaaccu                                                                187


<210>  426
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  histone stem-loop sequence

<400>  426
caaaggctct tttcagagcc acca                                              24


<210>  427
<211>  24
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  histone stem-loop sequence mRNA

<400>  427
caaaggcucu uuucagagcc acca                                              24


<210>  428
<211>  13
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Kozak

<400>  428
gccgccacca tgg                                                          13


<210>  429
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Kozak mRNA

<400>  429
gccgccacca ugg                                                          13


<210>  430
<211>  2023
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  R2763 MmIL-12 mRNA product TOP UTR opt1

<400>  430
ggggcgcugc cuacggaggu ggcagccauc uccuucucgg caucaagcuu accaugugcc       60

cccagaagcu gaccaucagc ugguucgcca ucgugcuccu ggucuccccg cugauggcca      120

ugugggagcu cgagaaggac guguacgugg ucgaggugga cuggaccccc gacgcgcccg      180

gcgagacggu gaaccugacc ugcgacaccc ccgaggagga cgacaucacc uggacgagcg      240

accagcggca cggggucauc ggcuccggga agacccugac caucaccgug aaggaguucc      300

ucgacgccgg ccaguacacg ugccacaagg gcggcgagac ccugagccac ucccaccugc      360

uccugcacaa gaaggagaac gggaucugga gcaccgagau ccugaagaac uucaagaaca      420

agaccuuccu caagugcgag gccccgaacu acuccgggcg cuucacgugc agcuggcugg      480

ugcagcggaa cauggaccug aaguucaaca ucaaguccag cuccagcucc cccgacagcc      540

gcgccgucac cugcggcaug gccucccuca gcgcggagaa ggugacccug gaccagcggg      600

acuacgagaa guacuccgug agcugccagg aggacgucac cugccccacg gccgaggaga      660

cccugcccau cgagcucgcc cuggaggccc gccagcagaa caaguacgag aacuacucca      720

ccagcuucuu cauccgggac aucaucaagc cggacccccc caagaaccug cagaugaagc      780

cccucaagaa cagccaggug gagguguccu gggaguaccc ggacagcugg uccaccccgc      840

acagcuacuu cucccugaag uucuucgucc gcauccagcg gaagaaggag aagaugaagg      900

agacggagga ggggugcaac cagaagggcg cguuccuggu ggagaagacc agcaccgagg      960

ugcagugcaa gggcgggaac gucugcgugc aggcccagga ccgguacuac aacuccagcu     1020

gcuccaagug ggccugcgug cccugccggg uccgcagcgg caguacuucg ggcaguggua     1080

agccugguag uggugagggu aguacuaagg gucgcgugau ccccgucagc ggcccggccc     1140

ggugccuguc ccagagccgc aaccugcuca agaccacgga cgacauggug aagaccgccc     1200

gggagaagcu gaagcacuac uccugcaccg ccgaggacau cgaccacgag gacaucaccc     1260

gcgaccagac gagcacccug aagaccugcc ucccccugga gcugcacaag aacgaguccu     1320

gccucgccac ccgggagacg agcuccacca cccgcgggag cugccugccg ccccagaaga     1380

ccucccugau gaugacgcuc ugccugggca gcaucuacga ggaccugaag auguaccaga     1440

ccgaguucca ggcgaucaac gccgcccucc agaaccacaa ccaccagcag aucauccugg     1500

acaaggggau gcugguggcc aucgacgagc ucaugcaguc ccugaaccac aacggcgaga     1560

cccugcggca gaagccgccc gucggggagg cggaccccua ccgcgugaag augaagcucu     1620

gcauccugcu gcacgccuuc agcacccggg uggucacgau caaccgcgug augggcuacc     1680

ucuccagcgc cugaggacua gugcaucaca uuuaaaagca ucucagccua ccaugagaau     1740

aagagaaaga aaaugaagau caauagcuua uucaucucuu uuucuuuuuc guugguguaa     1800

agccaacacc cugucuaaaa aacauaaauu ucuuuaauca uuuugccucu uuucucugug     1860

cuucaauuaa uaaaaaaugg aaagaaccua gaucuaaaaa aaaaaaaaaa aaaaaaaaaa     1920

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaau gcaucccccc cccccccccc     1980

cccccccccc cccccaaagg cucuuuucag agccaccaga auu                       2023


<210>  431
<211>  856
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  R3971 MmPdcd1(1-157,C83S) mRNA product TOP UTR opt1

<400>  431
ggggcgcugc cuacggaggu ggcagccauc uccuucucgg caucaagcuu accauguggg       60

ugcgccaggu ccccuggagc uucaccuggg ccgugcugca gcucuccugg cagagcggcu      120

ggcugcugga ggugccgaac gggcccuggc ggucccucac cuucuacccc gccuggcuga      180

cggucagcga gggcgcgaac gccaccuuca ccugcucccu gagcaacugg uccgaggacc      240

ucaugcugaa cuggaaccgc cugagccccu ccaaccagac cgagaagcag gccgccuuca      300

gcaacgggcu cucccagccg gugcaggacg cccgguucca gaucauccag cugcccaacc      360

gccacgacuu ccacaugaac auccuggaca cgcggcgcaa cgacagcggc aucuaccucu      420

gcggggcgau cucccugcac cccaaggcca agaucgagga gagccccggc gccgagcugg      480

uggucaccga gcggauccuc gagaccucca cccgcuaccc gagcugagga cuagugcauc      540

acauuuaaaa gcaucucagc cuaccaugag aauaagagaa agaaaaugaa gaucaauagc      600

uuauucaucu cuuuuucuuu uucguuggug uaaagccaac acccugucua aaaaacauaa      660

auuucuuuaa ucauuuugcc ucuuuucucu gugcuucaau uaauaaaaaa uggaaagaac      720

cuagaucuaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa      780

aaaaaaaaaa aaugcauccc cccccccccc cccccccccc ccccccccaa aggcucuuuu      840

cagagccacc agaauu                                                      856


<210>  432
<211>  1165
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  R3571 MmCd40lg mRNA product TOP UTR opt1

<400>  432
ggggcgcugc cuacggaggu ggcagccauc uccuucucgg caucaagcuu accaugaucg       60

agaccuacag ccagcccucc ccgcggagcg uggccaccgg ccugcccgcc uccaugaaga      120

ucuucaugua ccuccugacg gucuuccuga ucacccagau gaucgggagc gugcucuucg      180

cgguguaccu gcaccgccgg cuggacaagg ucgaggagga ggugaaccuc cacgaggacu      240

ucguguucau caagaagcug aagcgcugca acaagggcga ggggucccug agccuccuga      300

acugcgagga gaugcggcgc caguucgagg accuggucaa ggacaucacc cucaacaagg      360

aggagaagaa ggagaacucc uucgagaugc agcggggcga cgaggacccc cagaucgccg      420

cccacguggu gagcgaggcc aacuccaacg ccgcgagcgu ccugcagugg gccaagaagg      480

gguacuacac caugaagucc aaccugguga ugcucgagaa cggcaagcag cugacgguga      540

agcgcgaggg ccuguacuac gucuacaccc aggugaccuu cugcagcaac cgggagcccu      600

ccagccagcg cccguucauc guggggcucu ggcugaagcc cuccagcggc uccgagcgga      660

uccugcucaa ggccgccaac acccacagcu ccagccagcu gugcgagcag cagagcgucc      720

accugggcgg cguguucgag cuccaggcgg gggccuccgu guucgucaac gugacggagg      780

ccagccaggu gauccaccgc gucggguucu ccagcuucgg ccugcugaag cucugaggac      840

uagugcauca cauuuaaaag caucucagcc uaccaugaga auaagagaaa gaaaaugaag      900

aucaauagcu uauucaucuc uuuuucuuuu ucguuggugu aaagccaaca cccugucuaa      960

aaaacauaaa uuucuuuaau cauuuugccu cuuuucucug ugcuucaauu aauaaaaaau     1020

ggaaagaacc uagaucuaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa     1080

aaaaaaaaaa aaaaaaaaaa augcaucccc cccccccccc cccccccccc cccccccaaa     1140

ggcucuuuuc agagccacca gaauu                                           1165


<210>  433
<211>  547
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  R2025/R2391

<400>  433
gggagaaagc ucaagcuuau ccaaguaggc uggucaccug uacaacguag ccgguauuuu       60

uuuuuuuuuu uuuuuuuuga ccgucucaag guccaaguua gucugccuau aaaggugcgg      120

auccacagcu gaugaaagac uugugcggua cgguuaaucu ccccuuuuuu uuuuuuuuuu      180

uuuuuaguaa augcgucuac ugaauccagc gaugaugcug gcccagaucu ucgaccacaa      240

gugcauauag uagucaucga gggucgccuu uuuuuuuuuu uuuuuuuuuu uggcccaguu      300

cugagacuuc gcuagagacu acaguuacag cugcaguagu aaccacugcg gcuauugcag      360

gaaaucccgu ucagguuuuu uuuuuuuuuu uuuuuuccgc ucacuaugau uaagaaccag      420

guggaguguc acugcucucg aggucucacg agagcgcucg auacaguccu uggaagaauc      480

uuuuuuuuuu uuuuuuuuuu uugugcgacg aucacagaga acuucuauuc augcaggucu      540

gcucuag                                                                547


<210>  434
<211>  547
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  R3630/R3631

<400>  434
gggagaaagc ucaagcuuau ccaaguaggc uggucaccug uacaacguag ccgguauuuu       60

uuuuuuuuuu uuuuuuuuga ccgucucaag guccaaguua gucugccuau aaaggugcgg      120

auccacagcu gaugaaagac uugugcggua cgguuaaucu ccccuuuuuu uuuuuuuuuu      180

uuuuuaguaa augcgucuac ugaauccagc gaugaugcug gcccagaucu ucgaccacaa      240

gugcauauag uagucaucga gggucgccuu uuuuuuuuuu uuuuuuuuuu uggcccaguu      300

cugagacuuc gcuagagacu acaguuacag cugcaguagu aaccacugcg gcuauugcag      360

gaaaucccgu ucagguuuuu uuuuuuuuuu uuuuuuccgc ucacuaugau uaagaaccag      420

guggaguguc acugcucucg aggucucacg agagcgcucg auacagugcu uggaagaauc      480

uuuuuuuuuu uuuuuuuuuu uugugcgacg aucacagaga acuucuauuc augcaggucu      540

gcucuag                                                                547


<210>  435
<211>  546
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  R722

<400>  435
gggagaaagc ucaagcuuau ccaaguaggc uggucaccug uacaacguag ccgguauuuu       60

uuuuuuuuuu uuuuuuuuga ccgucucaag guccaaguua gucugccuau aaaggugcgg      120

auccacagcu gaugaaagac uugugcggua cgguuaaucu ccccuuuuuu uuuuuuuuuu      180

uuuuuaguaa augcgucuac ugaauccagc gaugaugcug gcccagaucu ucgaccacaa      240

gugcauauag uagucaucga gggucgccuu uuuuuuuuuu uuuuuuuuuu uggcccaguu      300

cugagacuuc gcuagagacu acaguuacag cugcaguagu aaccacugcg gcuauugcag      360

gaaaucccgu ucagguuuuu uuuuuuuuuu uuuuuuccgc ucacuaugau uaagaaccag      420

guggaguguc acugcucucg aggucucacg agagcgcucg auacaguccu uggaagaauc      480

uuuuuuuuuu uuuuuuuuuu uugugcgacg aucacagaga acuucuauuc augcaggucu      540

gcucua                                                                 546


<210>  436
<211>  1083
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  R723

<400>  436
gggagaaagc ucaagcuuau ccaaguaggc uggucaccug uacaacguag ccgguauuuu       60

uuuuuuuuuu uuuuuuuuga ccgucucaag guccaaguua gucugccuau aaaggugcgg      120

auccacagcu gaugaaagac uugugcggua cgguuaaucu ccccuuuuuu uuuuuuuuuu      180

uuuuuaguaa augcgucuac ugaauccagc gaugaugcug gcccagaucu ucgaccacaa      240

gugcauauag uagucaucga gggucgccuu uuuuuuuuuu uuuuuuuuuu uggcccaguu      300

cugagacuuc gcuagagacu acaguuacag cugcaguagu aaccacugcg gcuauugcag      360

gaaaucccgu ucagguuuuu uuuuuuuuuu uuuuuuccgc ucacuaugau uaagaaccag      420

guggaguguc acugcucucg aggucucacg agagcgcucg auacaguccu uggaagaauc      480

uuuuuuuuuu uuuuuuuuuu uugugcgacg aucacagaga acuucuauuc augcaggucu      540

gcucuagaac gaacugaccu gacgccugaa cuuaugagcg ugcguauuuu uuuuuuuuuu      600

uuuuuuuuuc cucccaacaa augucgauca auagcugggc uguuggagac gcgucagcaa      660

augccguggc uccauaggac guguagacuu cuauuuuuuu uuuuuuuuuu uuuucccggg      720

accacaaaua auauucuugc uugguugggc gcaagggccc cguaucaggu cauaaacggg      780

uacauguugc acaggcuccu uuuuuuuuuu uuuuuuuuuu uucgcugagu uauuccgguc      840

ucaaaagacg gcagacguca gucgacaaca cggucuaaag cagugcuaca aucugccgug      900

uucguguuuu uuuuuuuuuu uuuuuuguga accuacacgg cgugcacugu aguucgcaau      960

ucauagggua ccggcucaga guuaugccuu gguugaaaac ugcccagcau acuuuuuuuu     1020

uuuuuuuuuu uucauauucc caugcuaagc aagggaugcc gcgagucaug uuaagcuuga     1080

auu                                                                   1083


<210>  437
<211>  229
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  R821

<400>  437
gggagaaagc ucaagcuuau ccaaguaggc uggucaccug uacaacguag ccgguauuuu       60

uuuuuuuuuu uuuuuuuuga ccgucucaag guccaaguua gucugccuau aaaggugcgg      120

auccacagcu gaugaaagac uugugcggua cgguuaaucu ccccuuuuuu uuuuuuuuuu      180

uuuuuaguaa augcgucuac ugaauccagc gaugaugcug gcccagauc                  229


<210>  438
<211>  867
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  PDCD1 CDS mRNA wild type

<400>  438
augcagaucc cacaggcgcc cuggccaguc gucugggcgg ugcuacaacu gggcuggcgg       60

ccaggauggu ucuuagacuc cccagacagg cccuggaacc cccccaccuu cuccccagcc      120

cugcucgugg ugaccgaagg ggacaacgcc accuucaccu guagcuucuc caacacaucg      180

gagagcuucg ugcuaaacug guaccgcaug agccccagca accagacgga caagcuggcc      240

gcuuuccccg aggaccgcag ccagcccggc caggacugcc gcuuccgugu cacacaacug      300

cccaacgggc gugacuucca caugagcgug gucagggccc ggcgcaauga cagcggcacc      360

uaccucugug gggccaucuc ccuggccccc aaggcgcaga ucaaagagag ccugcgggca      420

gagcucaggg ugacagagag aagggcagaa gugcccacag cccaccccag ccccucaccc      480

aggccagccg gccaguucca aacccuggug guuggugucg ugggcggccu gcugggcagc      540

cuggugcugc uagucugggu ccuggccguc aucugcuccc gggccgcacg agggacaaua      600

ggagccaggc gcaccggcca gccccugaag gaggaccccu cagccgugcc uguguucucu      660

guggacuaug gggagcugga uuuccagugg cgagagaaga ccccggagcc ccccgugccc      720

ugugucccug agcagacgga guaugccacc auugucuuuc cuagcggaau gggcaccuca      780

ucccccgccc gcaggggcuc agccgacggc ccucggagug cccagccacu gaggccugag      840

gauggacacu gcucuuggcc ccucuga                                          867


<210>  439
<211>  450
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  PDCD1(1-149) CDS mRNA wild type

<400>  439
augcagaucc cacaggcgcc cuggccaguc gucugggcgg ugcuacaacu gggcuggcgg       60

ccaggauggu ucuuagacuc cccagacagg cccuggaacc cccccaccuu cuccccagcc      120

cugcucgugg ugaccgaagg ggacaacgcc accuucaccu guagcuucuc caacacaucg      180

gagagcuucg ugcuaaacug guaccgcaug agccccagca accagacgga caagcuggcc      240

gcuuuccccg aggaccgcag ccagcccggc caggacugcc gcuuccgugu cacacaacug      300

cccaacgggc gugacuucca caugagcgug gucagggccc ggcgcaauga cagcggcacc      360

uaccucugug gggccaucuc ccuggccccc aaggcgcaga ucaaagagag ccugcgggca      420

gagcucaggg ugacagagag aagggcauga                                       450


<210>  440
<211>  660
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  IL12A CDS mRNA wild type

<400>  440
auguguccag cgcgcagccu ccuccuugug gcuacccugg uccuccugga ccaccucagu       60

uuggccagaa accuccccgu ggccacucca gacccaggaa uguucccaug ccuucaccac      120

ucccaaaacc ugcugagggc cgucagcaac augcuccaga aggccagaca aacucuagaa      180

uuuuacccuu gcacuucuga agagauugau caugaagaua ucacaaaaga uaaaaccagc      240

acaguggagg ccuguuuacc auuggaauua accaagaaug agaguugccu aaauuccaga      300

gagaccucuu ucauaacuaa ugggaguugc cuggccucca gaaagaccuc uuuuaugaug      360

gcccugugcc uuaguaguau uuaugaagac uugaagaugu accaggugga guucaagacc      420

augaaugcaa aacuucugau ggauccuaag aggcagaucu uucuagauca aaacaugcug      480

gcaguuauug augagcugau gcaggcccug aauuucaaca gugagacugu gccacaaaaa      540

uccucccuug aagaaccgga uuuuuauaaa acuaaaauca agcucugcau acuucuucau      600

gcuuucagaa uuagggcagu gacuauugau agagugauga gcuaucugaa ugcuuccuaa      660


<210>  441
<211>  657
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  IL12A(1-219) CDS mRNA wild type

<400>  441
auguguccag cgcgcagccu ccuccuugug gcuacccugg uccuccugga ccaccucagu       60

uuggccagaa accuccccgu ggccacucca gacccaggaa uguucccaug ccuucaccac      120

ucccaaaacc ugcugagggc cgucagcaac augcuccaga aggccagaca aacucuagaa      180

uuuuacccuu gcacuucuga agagauugau caugaagaua ucacaaaaga uaaaaccagc      240

acaguggagg ccuguuuacc auuggaauua accaagaaug agaguugccu aaauuccaga      300

gagaccucuu ucauaacuaa ugggaguugc cuggccucca gaaagaccuc uuuuaugaug      360

gcccugugcc uuaguaguau uuaugaagac uugaagaugu accaggugga guucaagacc      420

augaaugcaa aacuucugau ggauccuaag aggcagaucu uucuagauca aaacaugcug      480

gcaguuauug augagcugau gcaggcccug aauuucaaca gugagacugu gccacaaaaa      540

uccucccuug aagaaccgga uuuuuauaaa acuaaaauca agcucugcau acuucuucau      600

gcuuucagaa uuagggcagu gacuauugau agagugauga gcuaucugaa ugcuucc         657


<210>  442
<211>  594
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  IL12A(23-219) CDS mRNA wild type

<400>  442
agaaaccucc ccguggccac uccagaccca ggaauguucc caugccuuca ccacucccaa       60

aaccugcuga gggccgucag caacaugcuc cagaaggcca gacaaacucu agaauuuuac      120

ccuugcacuu cugaagagau ugaucaugaa gauaucacaa aagauaaaac cagcacagug      180

gaggccuguu uaccauugga auuaaccaag aaugagaguu gccuaaauuc cagagagacc      240

ucuuucauaa cuaaugggag uugccuggcc uccagaaaga ccucuuuuau gauggcccug      300

ugccuuagua guauuuauga agacuugaag auguaccagg uggaguucaa gaccaugaau      360

gcaaaacuuc ugauggaucc uaagaggcag aucuuucuag aucaaaacau gcuggcaguu      420

auugaugagc ugaugcaggc ccugaauuuc aacagugaga cugugccaca aaaauccucc      480

cuugaagaac cggauuuuua uaaaacuaaa aucaagcucu gcauacuucu ucaugcuuuc      540

agaauuaggg cagugacuau ugauagagug augagcuauc ugaaugcuuc cuaa            594


<210>  443
<211>  987
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  IL12B CDS mRNA wild type

<400>  443
augugucacc agcaguuggu caucucuugg uuuucccugg uuuuucuggc aucuccccuc       60

guggccauau gggaacugaa gaaagauguu uaugucguag aauuggauug guauccggau      120

gccccuggag aaaugguggu ccucaccugu gacaccccug aagaagaugg uaucaccugg      180

accuuggacc agagcaguga ggucuuaggc ucuggcaaaa cccugaccau ccaagucaaa      240

gaguuuggag augcuggcca guacaccugu cacaaaggag gcgagguucu aagccauucg      300

cuccugcugc uucacaaaaa ggaagaugga auuuggucca cugauauuuu aaaggaccag      360

aaagaaccca aaaauaagac cuuucuaaga ugcgaggcca agaauuauuc uggacguuuc      420

accuguuggu ggcugacgac aaucaguacu gauuugacau ucagugucaa aagcagcaga      480

ggcucaucug acccccaagg ggugacgugc ggagcugcua cacucucugc agagagaguc      540

agaggggaca acaaggagua ugaguacuca guggagugcc aggaggacag ugccugccca      600

gcugcugagg agagucugcc cauugagguc augguggaug ccguucacaa gcucaaguau      660

gaaaacuaca ccagcagcuu cuucaucagg gacaucauca aaccugaccc acccaagaac      720

uugcagcuga agccauuaaa aaauucucgg cagguugagg ucagcuggga guacccugac      780

accuggagua cuccacauuc cuacuucucc cugacauucu gcguucaggu ccagggcaag      840

agcaagagag aaaagaaaga uagagucuuc acggacaaga ccucagccac ggucaucugc      900

cgcaaaaaug ccagcauuag cgugcgggcc caggaccgcu acuauagcuc aucuuggagc      960

gaaugggcau cugugcccug caguuag                                          987


<210>  444
<211>  984
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  IL12B(1-328) CDS mRNA wild type

<400>  444
augugucacc agcaguuggu caucucuugg uuuucccugg uuuuucuggc aucuccccuc       60

guggccauau gggaacugaa gaaagauguu uaugucguag aauuggauug guauccggau      120

gccccuggag aaaugguggu ccucaccugu gacaccccug aagaagaugg uaucaccugg      180

accuuggacc agagcaguga ggucuuaggc ucuggcaaaa cccugaccau ccaagucaaa      240

gaguuuggag augcuggcca guacaccugu cacaaaggag gcgagguucu aagccauucg      300

cuccugcugc uucacaaaaa ggaagaugga auuuggucca cugauauuuu aaaggaccag      360

aaagaaccca aaaauaagac cuuucuaaga ugcgaggcca agaauuauuc uggacguuuc      420

accuguuggu ggcugacgac aaucaguacu gauuugacau ucagugucaa aagcagcaga      480

ggcucaucug acccccaagg ggugacgugc ggagcugcua cacucucugc agagagaguc      540

agaggggaca acaaggagua ugaguacuca guggagugcc aggaggacag ugccugccca      600

gcugcugagg agagucugcc cauugagguc augguggaug ccguucacaa gcucaaguau      660

gaaaacuaca ccagcagcuu cuucaucagg gacaucauca aaccugaccc acccaagaac      720

uugcagcuga agccauuaaa aaauucucgg cagguugagg ucagcuggga guacccugac      780

accuggagua cuccacauuc cuacuucucc cugacauucu gcguucaggu ccagggcaag      840

agcaagagag aaaagaaaga uagagucuuc acggacaaga ccucagccac ggucaucugc      900

cgcaaaaaug ccagcauuag cgugcgggcc caggaccgcu acuauagcuc aucuuggagc      960

gaaugggcau cugugcccug cagu                                             984


<210>  445
<211>  921
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  IL12B(23-328) CDS mRNA wild type

<400>  445
auaugggaac ugaagaaaga uguuuauguc guagaauugg auugguaucc ggaugccccu       60

ggagaaaugg ugguccucac cugugacacc ccugaagaag augguaucac cuggaccuug      120

gaccagagca gugaggucuu aggcucuggc aaaacccuga ccauccaagu caaagaguuu      180

ggagaugcug gccaguacac cugucacaaa ggaggcgagg uucuaagcca uucgcuccug      240

cugcuucaca aaaaggaaga uggaauuugg uccacugaua uuuuaaagga ccagaaagaa      300

cccaaaaaua agaccuuucu aagaugcgag gccaagaauu auucuggacg uuucaccugu      360

ugguggcuga cgacaaucag uacugauuug acauucagug ucaaaagcag cagaggcuca      420

ucugaccccc aaggggugac gugcggagcu gcuacacucu cugcagagag agucagaggg      480

gacaacaagg aguaugagua cucaguggag ugccaggagg acagugccug cccagcugcu      540

gaggagaguc ugcccauuga ggucauggug gaugccguuc acaagcucaa guaugaaaac      600

uacaccagca gcuucuucau cagggacauc aucaaaccug acccacccaa gaacuugcag      660

cugaagccau uaaaaaauuc ucggcagguu gaggucagcu gggaguaccc ugacaccugg      720

aguacuccac auuccuacuu cucccugaca uucugcguuc agguccaggg caagagcaag      780

agagaaaaga aagauagagu cuucacggac aagaccucag ccacggucau cugccgcaaa      840

aaugccagca uuagcgugcg ggcccaggac cgcuacuaua gcucaucuug gagcgaaugg      900

gcaucugugc ccugcaguua g                                                921


<210>  446
<211>  54
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Linker-sFvCC49-218 CDS mRNA wild type

<400>  446
ggcaguacuu cgggcagugg uaagccuggu aguggugagg guaguacuaa gggu             54


<210>  447
<211>  1632
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  IL12 CDS mRNA wild type

<400>  447
augugucacc agcaguuggu caucucuugg uuuucccugg uuuuucuggc aucuccccuc       60

guggccauau gggaacugaa gaaagauguu uaugucguag aauuggauug guauccggau      120

gccccuggag aaaugguggu ccucaccugu gacaccccug aagaagaugg uaucaccugg      180

accuuggacc agagcaguga ggucuuaggc ucuggcaaaa cccugaccau ccaagucaaa      240

gaguuuggag augcuggcca guacaccugu cacaaaggag gcgagguucu aagccauucg      300

cuccugcugc uucacaaaaa ggaagaugga auuuggucca cugauauuuu aaaggaccag      360

aaagaaccca aaaauaagac cuuucuaaga ugcgaggcca agaauuauuc uggacguuuc      420

accuguuggu ggcugacgac aaucaguacu gauuugacau ucagugucaa aagcagcaga      480

ggcucaucug acccccaagg ggugacgugc ggagcugcua cacucucugc agagagaguc      540

agaggggaca acaaggagua ugaguacuca guggagugcc aggaggacag ugccugccca      600

gcugcugagg agagucugcc cauugagguc augguggaug ccguucacaa gcucaaguau      660

gaaaacuaca ccagcagcuu cuucaucagg gacaucauca aaccugaccc acccaagaac      720

uugcagcuga agccauuaaa aaauucucgg cagguugagg ucagcuggga guacccugac      780

accuggagua cuccacauuc cuacuucucc cugacauucu gcguucaggu ccagggcaag      840

agcaagagag aaaagaaaga uagagucuuc acggacaaga ccucagccac ggucaucugc      900

cgcaaaaaug ccagcauuag cgugcgggcc caggaccgcu acuauagcuc aucuuggagc      960

gaaugggcau cugugcccug caguggcagu acuucgggca gugguaagcc ugguaguggu     1020

gaggguagua cuaaggguag aaaccucccc guggccacuc cagacccagg aauguuccca     1080

ugccuucacc acucccaaaa ccugcugagg gccgucagca acaugcucca gaaggccaga     1140

caaacucuag aauuuuaccc uugcacuucu gaagagauug aucaugaaga uaucacaaaa     1200

gauaaaacca gcacagugga ggccuguuua ccauuggaau uaaccaagaa ugagaguugc     1260

cuaaauucca gagagaccuc uuucauaacu aaugggaguu gccuggccuc cagaaagacc     1320

ucuuuuauga uggcccugug ccuuaguagu auuuaugaag acuugaagau guaccaggug     1380

gaguucaaga ccaugaaugc aaaacuucug auggauccua agaggcagau cuuucuagau     1440

caaaacaugc uggcaguuau ugaugagcug augcaggccc ugaauuucaa cagugagacu     1500

gugccacaaa aauccucccu ugaagaaccg gauuuuuaua aaacuaaaau caagcucugc     1560

auacuucuuc augcuuucag aauuagggca gugacuauug auagagugau gagcuaucug     1620

aaugcuuccu aa                                                         1632


<210>  448
<211>  786
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  CD40LG CDS mRNA wild type

<400>  448
augaucgaaa cauacaacca aacuucuccc cgaucugcgg ccacuggacu gcccaucagc       60

augaaaauuu uuauguauuu acuuacuguu uuucuuauca cccagaugau ugggucagca      120

cuuuuugcug uguaucuuca uagaagguug gacaagauag aagaugaaag gaaucuucau      180

gaagauuuug uauucaugaa aacgauacag agaugcaaca caggagaaag auccuuaucc      240

uuacugaacu gugaggagau uaaaagccag uuugaaggcu uugugaagga uauaauguua      300

aacaaagagg agacgaagaa agaaaacagc uuugaaaugc aaaaagguga ucagaauccu      360

caaauugcgg cacaugucau aagugaggcc agcaguaaaa caacaucugu guuacagugg      420

gcugaaaaag gauacuacac caugagcaac aacuugguaa cccuggaaaa ugggaaacag      480

cugaccguua aaagacaagg acucuauuau aucuaugccc aagucaccuu cuguuccaau      540

cgggaagcau cgagucaagc uccauuuaua gccagccucu gccuaaaguc ccccgguaga      600

uucgagagaa ucuuacucag agcugcaaau acccacaguu ccgccaaacc uugcgggcaa      660

caauccauuc acuugggagg aguauuugaa uugcaaccag gugcuucggu guuugucaau      720

gugacugauc caagccaagu gagccauggc acuggcuuca cguccuuugg cuuacucaaa      780

cucuga                                                                 786


<210>  449
<211>  1084
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  PDCD1 mRNA product wild type

<400>  449
gggagaaagc uuaccaugca gaucccacag gcgcccuggc cagucgucug ggcggugcua       60

caacugggcu ggcggccagg augguucuua gacuccccag acaggcccug gaaccccccc      120

accuucuccc cagcccugcu cguggugacc gaaggggaca acgccaccuu caccuguagc      180

uucuccaaca caucggagag cuucgugcua aacugguacc gcaugagccc cagcaaccag      240

acggacaagc uggccgcuuu ccccgaggac cgcagccagc ccggccagga cugccgcuuc      300

cgugucacac aacugcccaa cgggcgugac uuccacauga gcguggucag ggcccggcgc      360

aaugacagcg gcaccuaccu cuguggggcc aucucccugg cccccaaggc gcagaucaaa      420

gagagccugc gggcagagcu cagggugaca gagagaaggg cagaagugcc cacagcccac      480

cccagccccu cacccaggcc agccggccag uuccaaaccc uggugguugg ugucgugggc      540

ggccugcugg gcagccuggu gcugcuaguc uggguccugg ccgucaucug cucccgggcc      600

gcacgaggga caauaggagc caggcgcacc ggccagcccc ugaaggagga ccccucagcc      660

gugccugugu ucucugugga cuauggggag cuggauuucc aguggcgaga gaagaccccg      720

gagccccccg ugcccugugu cccugagcag acggaguaug ccaccauugu cuuuccuagc      780

ggaaugggca ccucaucccc cgcccgcagg ggcucagccg acggcccucg gagugcccag      840

ccacugaggc cugaggaugg acacugcucu uggccccucu gaggacuagu uauaagacug      900

acuagcccga ugggccuccc aacgggcccu ccuccccucc uugcaccgag auuaauaaaa      960

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa     1020

ugcauccccc cccccccccc cccccccccc ccccccaaag gcucuuuuca gagccaccag     1080

aauu                                                                  1084


<210>  450
<211>  667
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  PDCD1(1-149) mRNA product wild type

<400>  450
gggagaaagc uuaccaugca gaucccacag gcgcccuggc cagucgucug ggcggugcua       60

caacugggcu ggcggccagg augguucuua gacuccccag acaggcccug gaaccccccc      120

accuucuccc cagcccugcu cguggugacc gaaggggaca acgccaccuu caccuguagc      180

uucuccaaca caucggagag cuucgugcua aacugguacc gcaugagccc cagcaaccag      240

acggacaagc uggccgcuuu ccccgaggac cgcagccagc ccggccagga cugccgcuuc      300

cgugucacac aacugcccaa cgggcgugac uuccacauga gcguggucag ggcccggcgc      360

aaugacagcg gcaccuaccu cuguggggcc aucucccugg cccccaaggc gcagaucaaa      420

gagagccugc gggcagagcu cagggugaca gagagaaggg caugaggacu aguuauaaga      480

cugacuagcc cgaugggccu cccaacgggc ccuccucccc uccuugcacc gagauuaaua      540

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa      600

aaaugcaucc cccccccccc cccccccccc ccccccccca aaggcucuuu ucagagccac      660

cagaauu                                                                667


<210>  451
<211>  877
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  IL12A mRNA product wild type

<400>  451
gggagaaagc uuaccaugug uccagcgcgc agccuccucc uuguggcuac ccugguccuc       60

cuggaccacc ucaguuuggc cagaaaccuc cccguggcca cuccagaccc aggaauguuc      120

ccaugccuuc accacuccca aaaccugcug agggccguca gcaacaugcu ccagaaggcc      180

agacaaacuc uagaauuuua cccuugcacu ucugaagaga uugaucauga agauaucaca      240

aaagauaaaa ccagcacagu ggaggccugu uuaccauugg aauuaaccaa gaaugagagu      300

ugccuaaauu ccagagagac cucuuucaua acuaauggga guugccuggc cuccagaaag      360

accucuuuua ugauggcccu gugccuuagu aguauuuaug aagacuugaa gauguaccag      420

guggaguuca agaccaugaa ugcaaaacuu cugauggauc cuaagaggca gaucuuucua      480

gaucaaaaca ugcuggcagu uauugaugag cugaugcagg cccugaauuu caacagugag      540

acugugccac aaaaauccuc ccuugaagaa ccggauuuuu auaaaacuaa aaucaagcuc      600

ugcauacuuc uucaugcuuu cagaauuagg gcagugacua uugauagagu gaugagcuau      660

cugaaugcuu ccuaaggacu aguuauaaga cugacuagcc cgaugggccu cccaacgggc      720

ccuccucccc uccuugcacc gagauuaaua aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa      780

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaugcaucc cccccccccc cccccccccc      840

ccccccccca aaggcucuuu ucagagccac cagaauu                               877


<210>  452
<211>  874
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  IL12A(1-219) mRNA product wild type

<400>  452
gggagaaagc uuaccaugug uccagcgcgc agccuccucc uuguggcuac ccugguccuc       60

cuggaccacc ucaguuuggc cagaaaccuc cccguggcca cuccagaccc aggaauguuc      120

ccaugccuuc accacuccca aaaccugcug agggccguca gcaacaugcu ccagaaggcc      180

agacaaacuc uagaauuuua cccuugcacu ucugaagaga uugaucauga agauaucaca      240

aaagauaaaa ccagcacagu ggaggccugu uuaccauugg aauuaaccaa gaaugagagu      300

ugccuaaauu ccagagagac cucuuucaua acuaauggga guugccuggc cuccagaaag      360

accucuuuua ugauggcccu gugccuuagu aguauuuaug aagacuugaa gauguaccag      420

guggaguuca agaccaugaa ugcaaaacuu cugauggauc cuaagaggca gaucuuucua      480

gaucaaaaca ugcuggcagu uauugaugag cugaugcagg cccugaauuu caacagugag      540

acugugccac aaaaauccuc ccuugaagaa ccggauuuuu auaaaacuaa aaucaagcuc      600

ugcauacuuc uucaugcuuu cagaauuagg gcagugacua uugauagagu gaugagcuau      660

cugaaugcuu ccggacuagu uauaagacug acuagcccga ugggccuccc aacgggcccu      720

ccuccccucc uugcaccgag auuaauaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa      780

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa ugcauccccc cccccccccc cccccccccc      840

ccccccaaag gcucuuuuca gagccaccag aauu                                  874


<210>  453
<211>  811
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  IL12A(23-219) mRNA product wild type

<400>  453
gggagaaagc uuaccagaaa ccuccccgug gccacuccag acccaggaau guucccaugc       60

cuucaccacu cccaaaaccu gcugagggcc gucagcaaca ugcuccagaa ggccagacaa      120

acucuagaau uuuacccuug cacuucugaa gagauugauc augaagauau cacaaaagau      180

aaaaccagca caguggaggc cuguuuacca uuggaauuaa ccaagaauga gaguugccua      240

aauuccagag agaccucuuu cauaacuaau gggaguugcc uggccuccag aaagaccucu      300

uuuaugaugg cccugugccu uaguaguauu uaugaagacu ugaagaugua ccagguggag      360

uucaagacca ugaaugcaaa acuucugaug gauccuaaga ggcagaucuu ucuagaucaa      420

aacaugcugg caguuauuga ugagcugaug caggcccuga auuucaacag ugagacugug      480

ccacaaaaau ccucccuuga agaaccggau uuuuauaaaa cuaaaaucaa gcucugcaua      540

cuucuucaug cuuucagaau uagggcagug acuauugaua gagugaugag cuaucugaau      600

gcuuccuaag gacuaguuau aagacugacu agcccgaugg gccucccaac gggcccuccu      660

ccccuccuug caccgagauu aauaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa      720

aaaaaaaaaa aaaaaaaaaa aaaaaaaugc aucccccccc cccccccccc cccccccccc      780

cccaaaggcu cuuuucagag ccaccagaau u                                     811


<210>  454
<211>  1204
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  IL12B mRNA product wild type

<400>  454
gggagaaagc uuaccaugug ucaccagcag uuggucaucu cuugguuuuc ccugguuuuu       60

cuggcaucuc cccucguggc cauaugggaa cugaagaaag auguuuaugu cguagaauug      120

gauugguauc cggaugcccc uggagaaaug gugguccuca ccugugacac cccugaagaa      180

gaugguauca ccuggaccuu ggaccagagc agugaggucu uaggcucugg caaaacccug      240

accauccaag ucaaagaguu uggagaugcu ggccaguaca ccugucacaa aggaggcgag      300

guucuaagcc auucgcuccu gcugcuucac aaaaaggaag auggaauuug guccacugau      360

auuuuaaagg accagaaaga acccaaaaau aagaccuuuc uaagaugcga ggccaagaau      420

uauucuggac guuucaccug uugguggcug acgacaauca guacugauuu gacauucagu      480

gucaaaagca gcagaggcuc aucugacccc caagggguga cgugcggagc ugcuacacuc      540

ucugcagaga gagucagagg ggacaacaag gaguaugagu acucagugga gugccaggag      600

gacagugccu gcccagcugc ugaggagagu cugcccauug aggucauggu ggaugccguu      660

cacaagcuca aguaugaaaa cuacaccagc agcuucuuca ucagggacau caucaaaccu      720

gacccaccca agaacuugca gcugaagcca uuaaaaaauu cucggcaggu ugaggucagc      780

ugggaguacc cugacaccug gaguacucca cauuccuacu ucucccugac auucugcguu      840

cagguccagg gcaagagcaa gagagaaaag aaagauagag ucuucacgga caagaccuca      900

gccacgguca ucugccgcaa aaaugccagc auuagcgugc gggcccagga ccgcuacuau      960

agcucaucuu ggagcgaaug ggcaucugug cccugcaguu agggacuagu uauaagacug     1020

acuagcccga ugggccuccc aacgggcccu ccuccccucc uugcaccgag auuaauaaaa     1080

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa     1140

ugcauccccc cccccccccc cccccccccc ccccccaaag gcucuuuuca gagccaccag     1200

aauu                                                                  1204


<210>  455
<211>  1201
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  IL12B(1-328) mRNA product wild type

<400>  455
gggagaaagc uuaccaugug ucaccagcag uuggucaucu cuugguuuuc ccugguuuuu       60

cuggcaucuc cccucguggc cauaugggaa cugaagaaag auguuuaugu cguagaauug      120

gauugguauc cggaugcccc uggagaaaug gugguccuca ccugugacac cccugaagaa      180

gaugguauca ccuggaccuu ggaccagagc agugaggucu uaggcucugg caaaacccug      240

accauccaag ucaaagaguu uggagaugcu ggccaguaca ccugucacaa aggaggcgag      300

guucuaagcc auucgcuccu gcugcuucac aaaaaggaag auggaauuug guccacugau      360

auuuuaaagg accagaaaga acccaaaaau aagaccuuuc uaagaugcga ggccaagaau      420

uauucuggac guuucaccug uugguggcug acgacaauca guacugauuu gacauucagu      480

gucaaaagca gcagaggcuc aucugacccc caagggguga cgugcggagc ugcuacacuc      540

ucugcagaga gagucagagg ggacaacaag gaguaugagu acucagugga gugccaggag      600

gacagugccu gcccagcugc ugaggagagu cugcccauug aggucauggu ggaugccguu      660

cacaagcuca aguaugaaaa cuacaccagc agcuucuuca ucagggacau caucaaaccu      720

gacccaccca agaacuugca gcugaagcca uuaaaaaauu cucggcaggu ugaggucagc      780

ugggaguacc cugacaccug gaguacucca cauuccuacu ucucccugac auucugcguu      840

cagguccagg gcaagagcaa gagagaaaag aaagauagag ucuucacgga caagaccuca      900

gccacgguca ucugccgcaa aaaugccagc auuagcgugc gggcccagga ccgcuacuau      960

agcucaucuu ggagcgaaug ggcaucugug cccugcagug gacuaguuau aagacugacu     1020

agcccgaugg gccucccaac gggcccuccu ccccuccuug caccgagauu aauaaaaaaa     1080

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaugc     1140

aucccccccc cccccccccc cccccccccc cccaaaggcu cuuuucagag ccaccagaau     1200

u                                                                     1201


<210>  456
<211>  1138
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  IL12B(23-328) mRNA product wild type

<400>  456
gggagaaagc uuaccauaug ggaacugaag aaagauguuu augucguaga auuggauugg       60

uauccggaug ccccuggaga aauggugguc cucaccugug acaccccuga agaagauggu      120

aucaccugga ccuuggacca gagcagugag gucuuaggcu cuggcaaaac ccugaccauc      180

caagucaaag aguuuggaga ugcuggccag uacaccuguc acaaaggagg cgagguucua      240

agccauucgc uccugcugcu ucacaaaaag gaagauggaa uuugguccac ugauauuuua      300

aaggaccaga aagaacccaa aaauaagacc uuucuaagau gcgaggccaa gaauuauucu      360

ggacguuuca ccuguuggug gcugacgaca aucaguacug auuugacauu cagugucaaa      420

agcagcagag gcucaucuga cccccaaggg gugacgugcg gagcugcuac acucucugca      480

gagagaguca gaggggacaa caaggaguau gaguacucag uggagugcca ggaggacagu      540

gccugcccag cugcugagga gagucugccc auugagguca ugguggaugc cguucacaag      600

cucaaguaug aaaacuacac cagcagcuuc uucaucaggg acaucaucaa accugaccca      660

cccaagaacu ugcagcugaa gccauuaaaa aauucucggc agguugaggu cagcugggag      720

uacccugaca ccuggaguac uccacauucc uacuucuccc ugacauucug cguucagguc      780

cagggcaaga gcaagagaga aaagaaagau agagucuuca cggacaagac cucagccacg      840

gucaucugcc gcaaaaaugc cagcauuagc gugcgggccc aggaccgcua cuauagcuca      900

ucuuggagcg aaugggcauc ugugcccugc aguuagggac uaguuauaag acugacuagc      960

ccgaugggcc ucccaacggg cccuccuccc cuccuugcac cgagauuaau aaaaaaaaaa     1020

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaugcauc     1080

cccccccccc cccccccccc cccccccccc aaaggcucuu uucagagcca ccagaauu       1138


<210>  457
<211>  271
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Linker-sFvCC49-218 mRNA product wild type

<400>  457
gggagaaagc uuaccggcag uacuucgggc agugguaagc cugguagugg ugaggguagu       60

acuaagggug gacuaguuau aagacugacu agcccgaugg gccucccaac gggcccuccu      120

ccccuccuug caccgagauu aauaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa      180

aaaaaaaaaa aaaaaaaaaa aaaaaaaugc aucccccccc cccccccccc cccccccccc      240

cccaaaggcu cuuuucagag ccaccagaau u                                     271


<210>  458
<211>  1849
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  IL12 mRNA product wild type

<400>  458
gggagaaagc uuaccaugug ucaccagcag uuggucaucu cuugguuuuc ccugguuuuu       60

cuggcaucuc cccucguggc cauaugggaa cugaagaaag auguuuaugu cguagaauug      120

gauugguauc cggaugcccc uggagaaaug gugguccuca ccugugacac cccugaagaa      180

gaugguauca ccuggaccuu ggaccagagc agugaggucu uaggcucugg caaaacccug      240

accauccaag ucaaagaguu uggagaugcu ggccaguaca ccugucacaa aggaggcgag      300

guucuaagcc auucgcuccu gcugcuucac aaaaaggaag auggaauuug guccacugau      360

auuuuaaagg accagaaaga acccaaaaau aagaccuuuc uaagaugcga ggccaagaau      420

uauucuggac guuucaccug uugguggcug acgacaauca guacugauuu gacauucagu      480

gucaaaagca gcagaggcuc aucugacccc caagggguga cgugcggagc ugcuacacuc      540

ucugcagaga gagucagagg ggacaacaag gaguaugagu acucagugga gugccaggag      600

gacagugccu gcccagcugc ugaggagagu cugcccauug aggucauggu ggaugccguu      660

cacaagcuca aguaugaaaa cuacaccagc agcuucuuca ucagggacau caucaaaccu      720

gacccaccca agaacuugca gcugaagcca uuaaaaaauu cucggcaggu ugaggucagc      780

ugggaguacc cugacaccug gaguacucca cauuccuacu ucucccugac auucugcguu      840

cagguccagg gcaagagcaa gagagaaaag aaagauagag ucuucacgga caagaccuca      900

gccacgguca ucugccgcaa aaaugccagc auuagcgugc gggcccagga ccgcuacuau      960

agcucaucuu ggagcgaaug ggcaucugug cccugcagug gcaguacuuc gggcaguggu     1020

aagccuggua guggugaggg uaguacuaag gguagaaacc uccccguggc cacuccagac     1080

ccaggaaugu ucccaugccu ucaccacucc caaaaccugc ugagggccgu cagcaacaug     1140

cuccagaagg ccagacaaac ucuagaauuu uacccuugca cuucugaaga gauugaucau     1200

gaagauauca caaaagauaa aaccagcaca guggaggccu guuuaccauu ggaauuaacc     1260

aagaaugaga guugccuaaa uuccagagag accucuuuca uaacuaaugg gaguugccug     1320

gccuccagaa agaccucuuu uaugauggcc cugugccuua guaguauuua ugaagacuug     1380

aagauguacc agguggaguu caagaccaug aaugcaaaac uucugaugga uccuaagagg     1440

cagaucuuuc uagaucaaaa caugcuggca guuauugaug agcugaugca ggcccugaau     1500

uucaacagug agacugugcc acaaaaaucc ucccuugaag aaccggauuu uuauaaaacu     1560

aaaaucaagc ucugcauacu ucuucaugcu uucagaauua gggcagugac uauugauaga     1620

gugaugagcu aucugaaugc uuccuaagga cuaguuauaa gacugacuag cccgaugggc     1680

cucccaacgg gcccuccucc ccuccuugca ccgagauuaa uaaaaaaaaa aaaaaaaaaa     1740

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaugcau cccccccccc     1800

cccccccccc cccccccccc caaaggcucu uuucagagcc accagaauu                 1849


<210>  459
<211>  1003
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  CD40LG mRNA product wild type

<400>  459
gggagaaagc uuaccaugau cgaaacauac aaccaaacuu cuccccgauc ugcggccacu       60

ggacugccca ucagcaugaa aauuuuuaug uauuuacuua cuguuuuucu uaucacccag      120

augauugggu cagcacuuuu ugcuguguau cuucauagaa gguuggacaa gauagaagau      180

gaaaggaauc uucaugaaga uuuuguauuc augaaaacga uacagagaug caacacagga      240

gaaagauccu uauccuuacu gaacugugag gagauuaaaa gccaguuuga aggcuuugug      300

aaggauauaa uguuaaacaa agaggagacg aagaaagaaa acagcuuuga aaugcaaaaa      360

ggugaucaga auccucaaau ugcggcacau gucauaagug aggccagcag uaaaacaaca      420

ucuguguuac agugggcuga aaaaggauac uacaccauga gcaacaacuu gguaacccug      480

gaaaauggga aacagcugac cguuaaaaga caaggacucu auuauaucua ugcccaaguc      540

accuucuguu ccaaucggga agcaucgagu caagcuccau uuauagccag ccucugccua      600

aagucccccg guagauucga gagaaucuua cucagagcug caaauaccca caguuccgcc      660

aaaccuugcg ggcaacaauc cauucacuug ggaggaguau uugaauugca accaggugcu      720

ucgguguuug ucaaugugac ugauccaagc caagugagcc auggcacugg cuucacgucc      780

uuuggcuuac ucaaacucug aggacuaguu auaagacuga cuagcccgau gggccuccca      840

acgggcccuc cuccccuccu ugcaccgaga uuaauaaaaa aaaaaaaaaa aaaaaaaaaa      900

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaau gcaucccccc cccccccccc      960

cccccccccc cccccaaagg cucuuuucag agccaccaga auu                       1003


<210>  460
<211>  1249
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  PDCD1 mRNA product TOP UTR wild type

<400>  460
ggggcgcugc cuacggaggu ggcagccauc uccuucucgg caucaagcuu accaugcaga       60

ucccacaggc gcccuggcca gucgucuggg cggugcuaca acugggcugg cggccaggau      120

gguucuuaga cuccccagac aggcccugga acccccccac cuucucccca gcccugcucg      180

uggugaccga aggggacaac gccaccuuca ccuguagcuu cuccaacaca ucggagagcu      240

ucgugcuaaa cugguaccgc augagcccca gcaaccagac ggacaagcug gccgcuuucc      300

ccgaggaccg cagccagccc ggccaggacu gccgcuuccg ugucacacaa cugcccaacg      360

ggcgugacuu ccacaugagc guggucaggg cccggcgcaa ugacagcggc accuaccucu      420

guggggccau cucccuggcc cccaaggcgc agaucaaaga gagccugcgg gcagagcuca      480

gggugacaga gagaagggca gaagugccca cagcccaccc cagccccuca cccaggccag      540

ccggccaguu ccaaacccug gugguuggug ucgugggcgg ccugcugggc agccuggugc      600

ugcuagucug gguccuggcc gucaucugcu cccgggccgc acgagggaca auaggagcca      660

ggcgcaccgg ccagccccug aaggaggacc ccucagccgu gccuguguuc ucuguggacu      720

auggggagcu ggauuuccag uggcgagaga agaccccgga gccccccgug cccugugucc      780

cugagcagac ggaguaugcc accauugucu uuccuagcgg aaugggcacc ucaucccccg      840

cccgcagggg cucagccgac ggcccucgga gugcccagcc acugaggccu gaggauggac      900

acugcucuug gccccucuga ggacuagugc aucacauuua aaagcaucuc agccuaccau      960

gagaauaaga gaaagaaaau gaagaucaau agcuuauuca ucucuuuuuc uuuuucguug     1020

guguaaagcc aacacccugu cuaaaaaaca uaaauuucuu uaaucauuuu gccucuuuuc     1080

ucugugcuuc aauuaauaaa aaauggaaag aaccuagauc uaaaaaaaaa aaaaaaaaaa     1140

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaugcau cccccccccc     1200

cccccccccc cccccccccc caaaggcucu uuucagagcc accagaauu                 1249


<210>  461
<211>  832
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  PDCD1(1-149) mRNA product TOP UTR wild type

<400>  461
ggggcgcugc cuacggaggu ggcagccauc uccuucucgg caucaagcuu accaugcaga       60

ucccacaggc gcccuggcca gucgucuggg cggugcuaca acugggcugg cggccaggau      120

gguucuuaga cuccccagac aggcccugga acccccccac cuucucccca gcccugcucg      180

uggugaccga aggggacaac gccaccuuca ccuguagcuu cuccaacaca ucggagagcu      240

ucgugcuaaa cugguaccgc augagcccca gcaaccagac ggacaagcug gccgcuuucc      300

ccgaggaccg cagccagccc ggccaggacu gccgcuuccg ugucacacaa cugcccaacg      360

ggcgugacuu ccacaugagc guggucaggg cccggcgcaa ugacagcggc accuaccucu      420

guggggccau cucccuggcc cccaaggcgc agaucaaaga gagccugcgg gcagagcuca      480

gggugacaga gagaagggca ugaggacuag ugcaucacau uuaaaagcau cucagccuac      540

caugagaaua agagaaagaa aaugaagauc aauagcuuau ucaucucuuu uucuuuuucg      600

uugguguaaa gccaacaccc ugucuaaaaa acauaaauuu cuuuaaucau uuugccucuu      660

uucucugugc uucaauuaau aaaaaaugga aagaaccuag aucuaaaaaa aaaaaaaaaa      720

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaug cauccccccc      780

cccccccccc cccccccccc ccccaaaggc ucuuuucaga gccaccagaa uu              832


<210>  462
<211>  1042
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  IL12A mRNA product TOP UTR wild type

<400>  462
ggggcgcugc cuacggaggu ggcagccauc uccuucucgg caucaagcuu accauguguc       60

cagcgcgcag ccuccuccuu guggcuaccc ugguccuccu ggaccaccuc aguuuggcca      120

gaaaccuccc cguggccacu ccagacccag gaauguuccc augccuucac cacucccaaa      180

accugcugag ggccgucagc aacaugcucc agaaggccag acaaacucua gaauuuuacc      240

cuugcacuuc ugaagagauu gaucaugaag auaucacaaa agauaaaacc agcacagugg      300

aggccuguuu accauuggaa uuaaccaaga augagaguug ccuaaauucc agagagaccu      360

cuuucauaac uaaugggagu ugccuggccu ccagaaagac cucuuuuaug auggcccugu      420

gccuuaguag uauuuaugaa gacuugaaga uguaccaggu ggaguucaag accaugaaug      480

caaaacuucu gauggauccu aagaggcaga ucuuucuaga ucaaaacaug cuggcaguua      540

uugaugagcu gaugcaggcc cugaauuuca acagugagac ugugccacaa aaauccuccc      600

uugaagaacc ggauuuuuau aaaacuaaaa ucaagcucug cauacuucuu caugcuuuca      660

gaauuagggc agugacuauu gauagaguga ugagcuaucu gaaugcuucc uaaggacuag      720

ugcaucacau uuaaaagcau cucagccuac caugagaaua agagaaagaa aaugaagauc      780

aauagcuuau ucaucucuuu uucuuuuucg uugguguaaa gccaacaccc ugucuaaaaa      840

acauaaauuu cuuuaaucau uuugccucuu uucucugugc uucaauuaau aaaaaaugga      900

aagaaccuag aucuaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa      960

aaaaaaaaaa aaaaaaaaug cauccccccc cccccccccc cccccccccc ccccaaaggc     1020

ucuuuucaga gccaccagaa uu                                              1042


<210>  463
<211>  1039
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  IL12A(1-219) mRNA product TOP UTR wild type

<400>  463
ggggcgcugc cuacggaggu ggcagccauc uccuucucgg caucaagcuu accauguguc       60

cagcgcgcag ccuccuccuu guggcuaccc ugguccuccu ggaccaccuc aguuuggcca      120

gaaaccuccc cguggccacu ccagacccag gaauguuccc augccuucac cacucccaaa      180

accugcugag ggccgucagc aacaugcucc agaaggccag acaaacucua gaauuuuacc      240

cuugcacuuc ugaagagauu gaucaugaag auaucacaaa agauaaaacc agcacagugg      300

aggccuguuu accauuggaa uuaaccaaga augagaguug ccuaaauucc agagagaccu      360

cuuucauaac uaaugggagu ugccuggccu ccagaaagac cucuuuuaug auggcccugu      420

gccuuaguag uauuuaugaa gacuugaaga uguaccaggu ggaguucaag accaugaaug      480

caaaacuucu gauggauccu aagaggcaga ucuuucuaga ucaaaacaug cuggcaguua      540

uugaugagcu gaugcaggcc cugaauuuca acagugagac ugugccacaa aaauccuccc      600

uugaagaacc ggauuuuuau aaaacuaaaa ucaagcucug cauacuucuu caugcuuuca      660

gaauuagggc agugacuauu gauagaguga ugagcuaucu gaaugcuucc ggacuagugc      720

aucacauuua aaagcaucuc agccuaccau gagaauaaga gaaagaaaau gaagaucaau      780

agcuuauuca ucucuuuuuc uuuuucguug guguaaagcc aacacccugu cuaaaaaaca      840

uaaauuucuu uaaucauuuu gccucuuuuc ucugugcuuc aauuaauaaa aaauggaaag      900

aaccuagauc uaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa      960

aaaaaaaaaa aaaaaugcau cccccccccc cccccccccc cccccccccc caaaggcucu     1020

uuucagagcc accagaauu                                                  1039


<210>  464
<211>  976
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  IL12A(23-219) mRNA product TOP UTR wild type

<400>  464
ggggcgcugc cuacggaggu ggcagccauc uccuucucgg caucaagcuu accagaaacc       60

uccccguggc cacuccagac ccaggaaugu ucccaugccu ucaccacucc caaaaccugc      120

ugagggccgu cagcaacaug cuccagaagg ccagacaaac ucuagaauuu uacccuugca      180

cuucugaaga gauugaucau gaagauauca caaaagauaa aaccagcaca guggaggccu      240

guuuaccauu ggaauuaacc aagaaugaga guugccuaaa uuccagagag accucuuuca      300

uaacuaaugg gaguugccug gccuccagaa agaccucuuu uaugauggcc cugugccuua      360

guaguauuua ugaagacuug aagauguacc agguggaguu caagaccaug aaugcaaaac      420

uucugaugga uccuaagagg cagaucuuuc uagaucaaaa caugcuggca guuauugaug      480

agcugaugca ggcccugaau uucaacagug agacugugcc acaaaaaucc ucccuugaag      540

aaccggauuu uuauaaaacu aaaaucaagc ucugcauacu ucuucaugcu uucagaauua      600

gggcagugac uauugauaga gugaugagcu aucugaaugc uuccuaagga cuagugcauc      660

acauuuaaaa gcaucucagc cuaccaugag aauaagagaa agaaaaugaa gaucaauagc      720

uuauucaucu cuuuuucuuu uucguuggug uaaagccaac acccugucua aaaaacauaa      780

auuucuuuaa ucauuuugcc ucuuuucucu gugcuucaau uaauaaaaaa uggaaagaac      840

cuagaucuaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa      900

aaaaaaaaaa aaugcauccc cccccccccc cccccccccc ccccccccaa aggcucuuuu      960

cagagccacc agaauu                                                      976


<210>  465
<211>  1369
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  IL12B mRNA product TOP UTR wild type

<400>  465
ggggcgcugc cuacggaggu ggcagccauc uccuucucgg caucaagcuu accauguguc       60

accagcaguu ggucaucucu ugguuuuccc ugguuuuucu ggcaucuccc cucguggcca      120

uaugggaacu gaagaaagau guuuaugucg uagaauugga uugguauccg gaugccccug      180

gagaaauggu gguccucacc ugugacaccc cugaagaaga ugguaucacc uggaccuugg      240

accagagcag ugaggucuua ggcucuggca aaacccugac cauccaaguc aaagaguuug      300

gagaugcugg ccaguacacc ugucacaaag gaggcgaggu ucuaagccau ucgcuccugc      360

ugcuucacaa aaaggaagau ggaauuuggu ccacugauau uuuaaaggac cagaaagaac      420

ccaaaaauaa gaccuuucua agaugcgagg ccaagaauua uucuggacgu uucaccuguu      480

gguggcugac gacaaucagu acugauuuga cauucagugu caaaagcagc agaggcucau      540

cugaccccca aggggugacg ugcggagcug cuacacucuc ugcagagaga gucagagggg      600

acaacaagga guaugaguac ucaguggagu gccaggagga cagugccugc ccagcugcug      660

aggagagucu gcccauugag gucauggugg augccguuca caagcucaag uaugaaaacu      720

acaccagcag cuucuucauc agggacauca ucaaaccuga cccacccaag aacuugcagc      780

ugaagccauu aaaaaauucu cggcagguug aggucagcug ggaguacccu gacaccugga      840

guacuccaca uuccuacuuc ucccugacau ucugcguuca gguccagggc aagagcaaga      900

gagaaaagaa agauagaguc uucacggaca agaccucagc cacggucauc ugccgcaaaa      960

augccagcau uagcgugcgg gcccaggacc gcuacuauag cucaucuugg agcgaauggg     1020

caucugugcc cugcaguuag ggacuagugc aucacauuua aaagcaucuc agccuaccau     1080

gagaauaaga gaaagaaaau gaagaucaau agcuuauuca ucucuuuuuc uuuuucguug     1140

guguaaagcc aacacccugu cuaaaaaaca uaaauuucuu uaaucauuuu gccucuuuuc     1200

ucugugcuuc aauuaauaaa aaauggaaag aaccuagauc uaaaaaaaaa aaaaaaaaaa     1260

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaugcau cccccccccc     1320

cccccccccc cccccccccc caaaggcucu uuucagagcc accagaauu                 1369


<210>  466
<211>  1366
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  IL12B(1-328) mRNA product TOP UTR wild type

<400>  466
ggggcgcugc cuacggaggu ggcagccauc uccuucucgg caucaagcuu accauguguc       60

accagcaguu ggucaucucu ugguuuuccc ugguuuuucu ggcaucuccc cucguggcca      120

uaugggaacu gaagaaagau guuuaugucg uagaauugga uugguauccg gaugccccug      180

gagaaauggu gguccucacc ugugacaccc cugaagaaga ugguaucacc uggaccuugg      240

accagagcag ugaggucuua ggcucuggca aaacccugac cauccaaguc aaagaguuug      300

gagaugcugg ccaguacacc ugucacaaag gaggcgaggu ucuaagccau ucgcuccugc      360

ugcuucacaa aaaggaagau ggaauuuggu ccacugauau uuuaaaggac cagaaagaac      420

ccaaaaauaa gaccuuucua agaugcgagg ccaagaauua uucuggacgu uucaccuguu      480

gguggcugac gacaaucagu acugauuuga cauucagugu caaaagcagc agaggcucau      540

cugaccccca aggggugacg ugcggagcug cuacacucuc ugcagagaga gucagagggg      600

acaacaagga guaugaguac ucaguggagu gccaggagga cagugccugc ccagcugcug      660

aggagagucu gcccauugag gucauggugg augccguuca caagcucaag uaugaaaacu      720

acaccagcag cuucuucauc agggacauca ucaaaccuga cccacccaag aacuugcagc      780

ugaagccauu aaaaaauucu cggcagguug aggucagcug ggaguacccu gacaccugga      840

guacuccaca uuccuacuuc ucccugacau ucugcguuca gguccagggc aagagcaaga      900

gagaaaagaa agauagaguc uucacggaca agaccucagc cacggucauc ugccgcaaaa      960

augccagcau uagcgugcgg gcccaggacc gcuacuauag cucaucuugg agcgaauggg     1020

caucugugcc cugcagugga cuagugcauc acauuuaaaa gcaucucagc cuaccaugag     1080

aauaagagaa agaaaaugaa gaucaauagc uuauucaucu cuuuuucuuu uucguuggug     1140

uaaagccaac acccugucua aaaaacauaa auuucuuuaa ucauuuugcc ucuuuucucu     1200

gugcuucaau uaauaaaaaa uggaaagaac cuagaucuaa aaaaaaaaaa aaaaaaaaaa     1260

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaugcauccc cccccccccc     1320

cccccccccc ccccccccaa aggcucuuuu cagagccacc agaauu                    1366


<210>  467
<211>  1303
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  IL12B(23-328) mRNA product TOP UTR wild type

<400>  467
ggggcgcugc cuacggaggu ggcagccauc uccuucucgg caucaagcuu accauauggg       60

aacugaagaa agauguuuau gucguagaau uggauuggua uccggaugcc ccuggagaaa      120

uggugguccu caccugugac accccugaag aagaugguau caccuggacc uuggaccaga      180

gcagugaggu cuuaggcucu ggcaaaaccc ugaccaucca agucaaagag uuuggagaug      240

cuggccagua caccugucac aaaggaggcg agguucuaag ccauucgcuc cugcugcuuc      300

acaaaaagga agauggaauu ugguccacug auauuuuaaa ggaccagaaa gaacccaaaa      360

auaagaccuu ucuaagaugc gaggccaaga auuauucugg acguuucacc uguugguggc      420

ugacgacaau caguacugau uugacauuca gugucaaaag cagcagaggc ucaucugacc      480

cccaaggggu gacgugcgga gcugcuacac ucucugcaga gagagucaga ggggacaaca      540

aggaguauga guacucagug gagugccagg aggacagugc cugcccagcu gcugaggaga      600

gucugcccau ugaggucaug guggaugccg uucacaagcu caaguaugaa aacuacacca      660

gcagcuucuu caucagggac aucaucaaac cugacccacc caagaacuug cagcugaagc      720

cauuaaaaaa uucucggcag guugagguca gcugggagua cccugacacc uggaguacuc      780

cacauuccua cuucucccug acauucugcg uucaggucca gggcaagagc aagagagaaa      840

agaaagauag agucuucacg gacaagaccu cagccacggu caucugccgc aaaaaugcca      900

gcauuagcgu gcgggcccag gaccgcuacu auagcucauc uuggagcgaa ugggcaucug      960

ugcccugcag uuagggacua gugcaucaca uuuaaaagca ucucagccua ccaugagaau     1020

aagagaaaga aaaugaagau caauagcuua uucaucucuu uuucuuuuuc guugguguaa     1080

agccaacacc cugucuaaaa aacauaaauu ucuuuaauca uuuugccucu uuucucugug     1140

cuucaauuaa uaaaaaaugg aaagaaccua gaucuaaaaa aaaaaaaaaa aaaaaaaaaa     1200

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaau gcaucccccc cccccccccc     1260

cccccccccc cccccaaagg cucuuuucag agccaccaga auu                       1303


<210>  468
<211>  436
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Linker-sFvCC49-218 mRNA product TOP UTR wild type

<400>  468
ggggcgcugc cuacggaggu ggcagccauc uccuucucgg caucaagcuu accggcagua       60

cuucgggcag ugguaagccu gguaguggug aggguaguac uaagggugga cuagugcauc      120

acauuuaaaa gcaucucagc cuaccaugag aauaagagaa agaaaaugaa gaucaauagc      180

uuauucaucu cuuuuucuuu uucguuggug uaaagccaac acccugucua aaaaacauaa      240

auuucuuuaa ucauuuugcc ucuuuucucu gugcuucaau uaauaaaaaa uggaaagaac      300

cuagaucuaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa      360

aaaaaaaaaa aaugcauccc cccccccccc cccccccccc ccccccccaa aggcucuuuu      420

cagagccacc agaauu                                                      436


<210>  469
<211>  2014
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  IL12 mRNA product TOP UTR wild type

<400>  469
ggggcgcugc cuacggaggu ggcagccauc uccuucucgg caucaagcuu accauguguc       60

accagcaguu ggucaucucu ugguuuuccc ugguuuuucu ggcaucuccc cucguggcca      120

uaugggaacu gaagaaagau guuuaugucg uagaauugga uugguauccg gaugccccug      180

gagaaauggu gguccucacc ugugacaccc cugaagaaga ugguaucacc uggaccuugg      240

accagagcag ugaggucuua ggcucuggca aaacccugac cauccaaguc aaagaguuug      300

gagaugcugg ccaguacacc ugucacaaag gaggcgaggu ucuaagccau ucgcuccugc      360

ugcuucacaa aaaggaagau ggaauuuggu ccacugauau uuuaaaggac cagaaagaac      420

ccaaaaauaa gaccuuucua agaugcgagg ccaagaauua uucuggacgu uucaccuguu      480

gguggcugac gacaaucagu acugauuuga cauucagugu caaaagcagc agaggcucau      540

cugaccccca aggggugacg ugcggagcug cuacacucuc ugcagagaga gucagagggg      600

acaacaagga guaugaguac ucaguggagu gccaggagga cagugccugc ccagcugcug      660

aggagagucu gcccauugag gucauggugg augccguuca caagcucaag uaugaaaacu      720

acaccagcag cuucuucauc agggacauca ucaaaccuga cccacccaag aacuugcagc      780

ugaagccauu aaaaaauucu cggcagguug aggucagcug ggaguacccu gacaccugga      840

guacuccaca uuccuacuuc ucccugacau ucugcguuca gguccagggc aagagcaaga      900

gagaaaagaa agauagaguc uucacggaca agaccucagc cacggucauc ugccgcaaaa      960

augccagcau uagcgugcgg gcccaggacc gcuacuauag cucaucuugg agcgaauggg     1020

caucugugcc cugcaguggc aguacuucgg gcagugguaa gccugguagu ggugagggua     1080

guacuaaggg uagaaaccuc cccguggcca cuccagaccc aggaauguuc ccaugccuuc     1140

accacuccca aaaccugcug agggccguca gcaacaugcu ccagaaggcc agacaaacuc     1200

uagaauuuua cccuugcacu ucugaagaga uugaucauga agauaucaca aaagauaaaa     1260

ccagcacagu ggaggccugu uuaccauugg aauuaaccaa gaaugagagu ugccuaaauu     1320

ccagagagac cucuuucaua acuaauggga guugccuggc cuccagaaag accucuuuua     1380

ugauggcccu gugccuuagu aguauuuaug aagacuugaa gauguaccag guggaguuca     1440

agaccaugaa ugcaaaacuu cugauggauc cuaagaggca gaucuuucua gaucaaaaca     1500

ugcuggcagu uauugaugag cugaugcagg cccugaauuu caacagugag acugugccac     1560

aaaaauccuc ccuugaagaa ccggauuuuu auaaaacuaa aaucaagcuc ugcauacuuc     1620

uucaugcuuu cagaauuagg gcagugacua uugauagagu gaugagcuau cugaaugcuu     1680

ccuaaggacu agugcaucac auuuaaaagc aucucagccu accaugagaa uaagagaaag     1740

aaaaugaaga ucaauagcuu auucaucucu uuuucuuuuu cguuggugua aagccaacac     1800

ccugucuaaa aaacauaaau uucuuuaauc auuuugccuc uuuucucugu gcuucaauua     1860

auaaaaaaug gaaagaaccu agaucuaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa     1920

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa ugcauccccc cccccccccc cccccccccc     1980

ccccccaaag gcucuuuuca gagccaccag aauu                                 2014


<210>  470
<211>  1168
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  CD40LG mRNA product TOP UTR wild type

<400>  470
ggggcgcugc cuacggaggu ggcagccauc uccuucucgg caucaagcuu accaugaucg       60

aaacauacaa ccaaacuucu ccccgaucug cggccacugg acugcccauc agcaugaaaa      120

uuuuuaugua uuuacuuacu guuuuucuua ucacccagau gauuggguca gcacuuuuug      180

cuguguaucu ucauagaagg uuggacaaga uagaagauga aaggaaucuu caugaagauu      240

uuguauucau gaaaacgaua cagagaugca acacaggaga aagauccuua uccuuacuga      300

acugugagga gauuaaaagc caguuugaag gcuuugugaa ggauauaaug uuaaacaaag      360

aggagacgaa gaaagaaaac agcuuugaaa ugcaaaaagg ugaucagaau ccucaaauug      420

cggcacaugu cauaagugag gccagcagua aaacaacauc uguguuacag ugggcugaaa      480

aaggauacua caccaugagc aacaacuugg uaacccugga aaaugggaaa cagcugaccg      540

uuaaaagaca aggacucuau uauaucuaug cccaagucac cuucuguucc aaucgggaag      600

caucgaguca agcuccauuu auagccagcc ucugccuaaa gucccccggu agauucgaga      660

gaaucuuacu cagagcugca aauacccaca guuccgccaa accuugcggg caacaaucca      720

uucacuuggg aggaguauuu gaauugcaac caggugcuuc gguguuuguc aaugugacug      780

auccaagcca agugagccau ggcacuggcu ucacguccuu uggcuuacuc aaacucugag      840

gacuagugca ucacauuuaa aagcaucuca gccuaccaug agaauaagag aaagaaaaug      900

aagaucaaua gcuuauucau cucuuuuucu uuuucguugg uguaaagcca acacccuguc      960

uaaaaaacau aaauuucuuu aaucauuuug ccucuuuucu cugugcuuca auuaauaaaa     1020

aauggaaaga accuagaucu aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa     1080

aaaaaaaaaa aaaaaaaaaa aaaaugcauc cccccccccc cccccccccc cccccccccc     1140

aaaggcucuu uucagagcca ccagaauu                                        1168


<210>  471
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Immune stimulatory RNA

<400>  471
gguuuuuuuu uuuuuuuggg                                                   20


<210>  472
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Immune stimulatory RNA

<400>  472
ggggguuuuu uuuuuggggg                                                   20


<210>  473
<211>  40
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Immune stimulatory RNA

<400>  473
ggggguuuuu uuuuuuuuuu uuuuuuuuuu uuuuuggggg                             40


<210>  474
<211>  39
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Immune stimulatory RNA

<400>  474
gugugugugu guuuuuuuuu uuuuuuugug ugugugugu                              39


<210>  475
<211>  39
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Immune stimulatory RNA

<400>  475
gguugguugg uuuuuuuuuu uuuuuuuggu ugguugguu                              39


<210>  476
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Immune stimulatory RNA

<400>  476
gggggggggu uugggggggg                                                   20


<210>  477
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Immune stimulatory RNA

<400>  477
gggggggguu uugggggggg                                                   20


<210>  478
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Immune stimulatory RNA

<400>  478
ggggggguuu uuuggggggg                                                   20


<210>  479
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Immune stimulatory RNA

<400>  479
ggggggguuu uuuugggggg                                                   20


<210>  480
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Immune stimulatory RNA

<400>  480
gggggguuuu uuuugggggg                                                   20


<210>  481
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Immune stimulatory RNA

<400>  481
gggggguuuu uuuuuggggg                                                   20


<210>  482
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Immune stimulatory RNA

<400>  482
gggggguuuu uuuuuugggg                                                   20


<210>  483
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Immune stimulatory RNA

<400>  483
ggggguuuuu uuuuuugggg                                                   20


<210>  484
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Immune stimulatory RNA

<400>  484
ggggguuuuu uuuuuuuggg                                                   20


<210>  485
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Immune stimulatory RNA

<400>  485
gggguuuuuu uuuuuuuggg                                                   20


<210>  486
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Immune stimulatory RNA

<400>  486
gggguuuuuu uuuuuuuugg                                                   20


<210>  487
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Immune stimulatory RNA

<400>  487
gguuuuuuuu uuuuuuuugg                                                   20


<210>  488
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Immune stimulatory RNA

<400>  488
guuuuuuuuu uuuuuuuuug                                                   20


<210>  489
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Immune stimulatory RNA

<400>  489
gggggggggg uuuggggggg gg                                                22


<210>  490
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Immune stimulatory RNA

<400>  490
gggggggggu uuuggggggg gg                                                22


<210>  491
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Immune stimulatory RNA

<400>  491
gggggggguu uuuugggggg gg                                                22


<210>  492
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Immune stimulatory RNA

<400>  492
gggggggguu uuuuuggggg gg                                                22


<210>  493
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Immune stimulatory RNA

<400>  493
ggggggguuu uuuuuggggg gg                                                22


<210>  494
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Immune stimulatory RNA

<400>  494
ggggggguuu uuuuuugggg gg                                                22


<210>  495
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Immune stimulatory RNA

<400>  495
ggggggguuu uuuuuuuggg gg                                                22


<210>  496
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Immune stimulatory RNA

<400>  496
gggggguuuu uuuuuuuggg gg                                                22


<210>  497
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Immune stimulatory RNA

<400>  497
gggggguuuu uuuuuuuugg gg                                                22


<210>  498
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Immune stimulatory RNA

<400>  498
ggggguuuuu uuuuuuuugg gg                                                22


<210>  499
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Immune stimulatory RNA

<400>  499
ggggguuuuu uuuuuuuuug gg                                                22


<210>  500
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Immune stimulatory RNA

<400>  500
ggguuuuuuu uuuuuuuuug gg                                                22


<210>  501
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Immune stimulatory RNA

<400>  501
gguuuuuuuu uuuuuuuuuu gg                                                22


<210>  502
<211>  24
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Immune stimulatory RNA

<400>  502
gggggggggg guuugggggg gggg                                              24


<210>  503
<211>  24
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Immune stimulatory RNA

<400>  503
gggggggggg uuuugggggg gggg                                              24


<210>  504
<211>  24
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Immune stimulatory RNA

<400>  504
gggggggggu uuuuuggggg gggg                                              24


<210>  505
<211>  24
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Immune stimulatory RNA

<400>  505
gggggggggu uuuuuugggg gggg                                              24


<210>  506
<211>  24
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Immune stimulatory RNA

<400>  506
gggggggguu uuuuuugggg gggg                                              24


<210>  507
<211>  24
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Immune stimulatory RNA

<400>  507
gggggggguu uuuuuuuggg gggg                                              24


<210>  508
<211>  24
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Immune stimulatory RNA

<400>  508
gggggggguu uuuuuuuugg gggg                                              24


<210>  509
<211>  24
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Immune stimulatory RNA

<400>  509
ggggggguuu uuuuuuuugg gggg                                              24


<210>  510
<211>  24
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Immune stimulatory RNA

<400>  510
ggggggguuu uuuuuuuuug gggg                                              24


<210>  511
<211>  24
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Immune stimulatory RNA

<400>  511
gggggguuuu uuuuuuuuug gggg                                              24


<210>  512
<211>  24
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Immune stimulatory RNA

<400>  512
gggggguuuu uuuuuuuuuu gggg                                              24


<210>  513
<211>  24
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Immune stimulatory RNA

<400>  513
gggguuuuuu uuuuuuuuuu gggg                                              24


<210>  514
<211>  24
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Immune stimulatory RNA

<400>  514
ggguuuuuuu uuuuuuuuuu uggg                                              24


<210>  515
<211>  32
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Immune stimulatory RNA

<400>  515
guuuuuuuuu uuuuuuuuuu uuuuuuuuuu ug                                     32


<210>  516
<211>  34
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Immune stimulatory RNA

<400>  516
gguuuuuuuu uuuuuuuuuu uuuuuuuuuu uugg                                   34


<210>  517
<211>  36
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Immune stimulatory RNA

<400>  517
ggguuuuuuu uuuuuuuuuu uuuuuuuuuu uuuggg                                 36


<210>  518
<211>  37
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Immune stimulatory RNA

<400>  518
gggguuuuuu uuuuuuuuuu uuuuuuuuuu uuuuggg                                37


<210>  519
<211>  39
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Immune stimulatory RNA

<400>  519
ggggguuuuu uuuuuuuuuu uuuuuuuuuu uuuuugggg                              39


<210>  520
<211>  41
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Immune stimulatory RNA

<400>  520
gggggguuuu uuuuuuuuuu uuuuuuuuuu uuuuuugggg g                           41


<210>  521
<211>  43
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Immune stimulatory RNA

<400>  521
ggggggguuu uuuuuuuuuu uuuuuuuuuu uuuuuuuggg ggg                         43


<210>  522
<211>  45
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Immune stimulatory RNA

<400>  522
gggggggguu uuuuuuuuuu uuuuuuuuuu uuuuuuuugg ggggg                       45


<210>  523
<211>  47
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Immune stimulatory RNA

<400>  523
gggggggggu uuuuuuuuuu uuuuuuuuuu uuuuuuuuug ggggggg                     47


<210>  524

<400>  524
000

<210>  525

<400>  525
000

<210>  526

<400>  526
000

<210>  527
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Immune stimulatory RNA

<400>  527
gguuuuuugg                                                              10


<210>  528
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Immune stimulatory RNA

<400>  528
gguuuuuuug g                                                            11


<210>  529
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Immune stimulatory RNA

<400>  529
gguuuuuuuu gg                                                           12


<210>  530
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Immune stimulatory RNA

<400>  530
gguuuuuuuu ugg                                                          13


<210>  531
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Immune stimulatory RNA

<400>  531
gguuuuuuuu uugg                                                         14


<210>  532
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Immune stimulatory RNA

<400>  532
gguuuuuuuu uuugg                                                        15


<210>  533
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Immune stimulatory RNA

<400>  533
gguuuuuuuu uuuugg                                                       16


<210>  534
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Immune stimulatory RNA

<400>  534
gguuuuuuuu uuuuugg                                                      17


<210>  535
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Immune stimulatory RNA

<400>  535
gguuuuuuuu uuuuuugg                                                     18


<210>  536
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Immune stimulatory RNA

<400>  536
gguuuuuuuu uuuuuuugg                                                    19


<210>  537

<400>  537
000

<210>  538
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Immune stimulatory RNA

<400>  538
ggguuuuggg                                                              10


<210>  539
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Immune stimulatory RNA

<400>  539
ggguuuuugg g                                                            11


<210>  540
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Immune stimulatory RNA

<400>  540
ggguuuuuug gg                                                           12


<210>  541
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Immune stimulatory RNA

<400>  541
ggguuuuuuu ggg                                                          13


<210>  542
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Immune stimulatory RNA

<400>  542
ggguuuuuuu uggg                                                         14


<210>  543
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Immune stimulatory RNA

<400>  543
ggguuuuuuu uuggg                                                        15


<210>  544
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Immune stimulatory RNA

<400>  544
ggguuuuuuu uuuggg                                                       16


<210>  545
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Immune stimulatory RNA

<400>  545
ggguuuuuuu uuuuggg                                                      17


<210>  546
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Immune stimulatory RNA

<400>  546
ggguuuuuuu uuuuuggg                                                     18


<210>  547
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Immune stimulatory RNA

<400>  547
ggguuuuuuu uuuuuuggg                                                    19


<210>  548
<211>  57
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Immune stimulatory RNA

<400>  548
ggguuuuuuu uuuuuuuugg guuuuuuuuu uuuuuugggu uuuuuuuuuu uuuuggg          57


<210>  549
<211>  42
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Immune stimulatory RNA

<400>  549
ggguuuuuuu uuuuuuuugg gggguuuuuu uuuuuuuuug gg                          42


<210>  550
<211>  51
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Immune stimulatory RNA

<400>  550
ggguuugggu uuggguuugg guuuggguuu ggguuugggu uuggguuugg g                51


<210>  551
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Immune stimulatory RNA

<400>  551
gguuuuuuuu uuuuuuuggg                                                   20


<210>  552
<211>  57
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Immune stimulatory RNA

<400>  552
cccuuuuuuu uuuuuuuucc cuuuuuuuuu uuuuuucccu uuuuuuuuuu uuuuccc          57


<210>  553
<211>  51
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Immune stimulatory RNA

<400>  553
cccuuucccu uucccuuucc cuuucccuuu cccuuucccu uucccuuucc c                51


<210>  554
<211>  42
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Immune stimulatory RNA

<400>  554
cccuuuuuuu uuuuuuuucc ccccuuuuuu uuuuuuuuuc cc                          42


<210>  555
<211>  60
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Immune stimulatory RNA

<400>  555
uagcgaagcu cuuggaccua gguuuuuuuu uuuuuuuggg ugcguuccua gaaguacacg       60


<210>  556
<211>  120
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Immune stimulatory RNA

<400>  556
uagcgaagcu cuuggaccua gguuuuuuuu uuuuuuuggg ugcguuccua gaaguacacg       60

aucgcuucga gaaccuggau ccaaaaaaaa aaaaaaaccc acgcaaggau cuucaugugc      120


<210>  557
<211>  229
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Immune stimulatory RNA

<400>  557
gggagaaagc ucaagcuugg agcaaugccc gcacauugag gaaaccgagu ugcauaucuc       60

agaguauugg cccccgugua gguuauucuu gacagacagu ggagcuuauu cacucccagg      120

auccgagucg cauacuacgg uacuggugac agaccuaggu cgucaguuga ccaguccgcc      180

acuagacgug aguccgucaa agcaguuaga uguuacacuc uauuagauc                  229


<210>  558
<211>  547
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Immune stimulatory RNA

<400>  558
gggagaaagc ucaagcuugg agcaaugccc gcacauugag gaaaccgagu ugcauaucuc       60

agaguauugg cccccgugua gguuauucuu gacagacagu ggagcuuauu cacucccagg      120

auccgagucg cauacuacgg uacuggugac agaccuaggu cgucaguuga ccaguccgcc      180

acuagacgug aguccgucaa agcaguuaga uguuacacuc uauuagaucu cggauuacag      240

cuggaaggag caggaguagu guucuugcuc uaaguaccga gugugcccaa uacccgauca      300

gcuuauuaac gaacggcucc uccucuuaga cugcagcgua agugcggaau cuggggauca      360

aauuacugac ugccuggauu acccucggac auauaaccuu guagcacgcu guugcuguau      420

aggugaccaa cgcccacucg aguagaccag cucucuuagu ccggacaaug auaggaggcg      480

cggucaaucu acuucuggcu aguuaagaau aggcugcacc gaccucuaua aguagcgugu      540

ccucuag                                                                547


<210>  559
<211>  1083
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Immune stimulatory RNA

<400>  559
gggagaaagc ucaagcuugg agcaaugccc gcacauugag gaaaccgagu ugcauaucuc       60

agaguauugg cccccgugua gguuauucuu gacagacagu ggagcuuauu cacucccagg      120

auccgagucg cauacuacgg uacuggugac agaccuaggu cgucaguuga ccaguccgcc      180

acuagacgug aguccgucaa agcaguuaga uguuacacuc uauuagaucu cggauuacag      240

cuggaaggag caggaguagu guucuugcuc uaaguaccga gugugcccaa uacccgauca      300

gcuuauuaac gaacggcucc uccucuuaga cugcagcgua agugcggaau cuggggauca      360

aauuacugac ugccuggauu acccucggac auauaaccuu guagcacgcu guugcuguau      420

aggugaccaa cgcccacucg aguagaccag cucucuuagu ccggacaaug auaggaggcg      480

cggucaaucu acuucuggcu aguuaagaau aggcugcacc gaccucuaua aguagcgugu      540

ccucuagagc uacgcagguu cgcaauaaaa gcguugauua gugugcauag aacagaccuc      600

uuauucggug aaacgccaga augcuaaauu ccaauaacuc uucccaaaac gcguacggcc      660

gaagacgcgc gcuuaucuug uguacguucu cgcacaugga agaaucagcg ggcauggugg      720

uagggcaaua ggggagcugg guagcagcga aaaagggccc cugcgcacgu agcuucgcug      780

uucgucugaa acaacccggc auccguugua gcgaucccgu uaucaguguu auucuugugc      840

gcacuaagau ucauggugua gucgacaaua acagcgucuu ggcagauucu ggucacgugc      900

ccuaugcccg ggcuugugcc ucucaggugc acagcgauac uuaaagccuu caagguacuc      960

gacgugggua ccgauucgug acacuuccua agauuauucc acuguguuag ccccgcaccg     1020

ccgaccuaaa cugguccaau guauacgcau ucgcugagcg gaucgauaau aaaagcuuga     1080

auu                                                                   1083


<210>  560
<211>  229
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Immune stimulatory RNA

<400>  560
gggagaaagc ucaagcuuau ccaaguaggc uggucaccug uacaacguag ccgguauuuu       60

uuuuuuuuuu uuuuuuuuga ccgucucaag guccaaguua gucugccuau aaaggugcgg      120

auccacagcu gaugaaagac uugugcggua cgguuaaucu ccccuuuuuu uuuuuuuuuu      180

uuuuuaguaa augcgucuac ugaauccagc gaugaugcug gcccagauc                  229


<210>  561
<211>  546
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Immune stimulatory RNA

<400>  561
gggagaaagc ucaagcuuau ccaaguaggc uggucaccug uacaacguag ccgguauuuu       60

uuuuuuuuuu uuuuuuuuga ccgucucaag guccaaguua gucugccuau aaaggugcgg      120

auccacagcu gaugaaagac uugugcggua cgguuaaucu ccccuuuuuu uuuuuuuuuu      180

uuuuuaguaa augcgucuac ugaauccagc gaugaugcug gcccagaucu ucgaccacaa      240

gugcauauag uagucaucga gggucgccuu uuuuuuuuuu uuuuuuuuuu uggcccaguu      300

cugagacuuc gcuagagacu acaguuacag cugcaguagu aaccacugcg gcuauugcag      360

gaaaucccgu ucagguuuuu uuuuuuuuuu uuuuuuccgc ucacuaugau uaagaaccag      420

guggaguguc acugcucucg aggucucacg agagcgcucg auacaguccu uggaagaauc      480

uuuuuuuuuu uuuuuuuuuu uugugcgacg aucacagaga acuucuauuc augcaggucu      540

gcucua                                                                 546


<210>  562
<211>  547
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Immune stimulatory RNA

<400>  562
gggagaaagc ucaagcuuau ccaaguaggc uggucaccug uacaacguag ccgguauuuu       60

uuuuuuuuuu uuuuuuuuga ccgucucaag guccaaguua gucugccuau aaaggugcgg      120

auccacagcu gaugaaagac uugugcggua cgguuaaucu ccccuuuuuu uuuuuuuuuu      180

uuuuuaguaa augcgucuac ugaauccagc gaugaugcug gcccagaucu ucgaccacaa      240

gugcauauag uagucaucga gggucgccuu uuuuuuuuuu uuuuuuuuuu uggcccaguu      300

cugagacuuc gcuagagacu acaguuacag cugcaguagu aaccacugcg gcuauugcag      360

gaaaucccgu ucagguuuuu uuuuuuuuuu uuuuuuccgc ucacuaugau uaagaaccag      420

guggaguguc acugcucucg aggucucacg agagcgcucg auacaguccu uggaagaauc      480

uuuuuuuuuu uuuuuuuuuu uugugcgacg aucacagaga acuucuauuc augcaggucu      540

gcucuag                                                                547


<210>  563
<211>  1083
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Immune stimulatory RNA

<400>  563
gggagaaagc ucaagcuuau ccaaguaggc uggucaccug uacaacguag ccgguauuuu       60

uuuuuuuuuu uuuuuuuuga ccgucucaag guccaaguua gucugccuau aaaggugcgg      120

auccacagcu gaugaaagac uugugcggua cgguuaaucu ccccuuuuuu uuuuuuuuuu      180

uuuuuaguaa augcgucuac ugaauccagc gaugaugcug gcccagaucu ucgaccacaa      240

gugcauauag uagucaucga gggucgccuu uuuuuuuuuu uuuuuuuuuu uggcccaguu      300

cugagacuuc gcuagagacu acaguuacag cugcaguagu aaccacugcg gcuauugcag      360

gaaaucccgu ucagguuuuu uuuuuuuuuu uuuuuuccgc ucacuaugau uaagaaccag      420

guggaguguc acugcucucg aggucucacg agagcgcucg auacaguccu uggaagaauc      480

uuuuuuuuuu uuuuuuuuuu uugugcgacg aucacagaga acuucuauuc augcaggucu      540

gcucuagaac gaacugaccu gacgccugaa cuuaugagcg ugcguauuuu uuuuuuuuuu      600

uuuuuuuuuc cucccaacaa augucgauca auagcugggc uguuggagac gcgucagcaa      660

augccguggc uccauaggac guguagacuu cuauuuuuuu uuuuuuuuuu uuuucccggg      720

accacaaaua auauucuugc uugguugggc gcaagggccc cguaucaggu cauaaacggg      780

uacauguugc acaggcuccu uuuuuuuuuu uuuuuuuuuu uucgcugagu uauuccgguc      840

ucaaaagacg gcagacguca gucgacaaca cggucuaaag cagugcuaca aucugccgug      900

uucguguuuu uuuuuuuuuu uuuuuuguga accuacacgg cgugcacugu aguucgcaau      960

ucauagggua ccggcucaga guuaugccuu gguugaaaac ugcccagcau acuuuuuuuu     1020

uuuuuuuuuu uucauauucc caugcuaagc aagggaugcc gcgagucaug uuaagcuuga     1080

auu                                                                   1083


<210>  564
<211>  59
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Immune stimulatory RNA

<400>  564
uagcgaagcu cuuggaccua ccuuuuuuuu uuuuuucccu gcguuccuag aaguacacg        59


<210>  565
<211>  120
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Immune stimulatory RNA

<400>  565
uagcgaagcu cuuggaccua ccuuuuuuuu uuuuuuuccc ugcguuccua gaaguacacg       60

aucgcuucga gaaccuggau ggaaaaaaaa aaaaaaaggg acgcaaggau cuucaugugc      120


<210>  566
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  cationic component of the polymeric carrier

<400>  566

Cys Arg Arg Arg Arg Arg Arg Arg Cys 
1               5                   


<210>  567
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  cationic component of the polymeric carrier

<400>  567

Cys Arg Arg Arg Arg Arg Arg Arg Arg Cys 
1               5                   10  


<210>  568
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  cationic component of the polymeric carrier

<400>  568

Cys Arg Arg Arg Arg Arg Arg Arg Arg Arg Cys 
1               5                   10      


<210>  569
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  cationic component of the polymeric carrier

<400>  569

Cys Arg Arg Arg Arg Arg Arg Arg Arg Arg Arg Cys 
1               5                   10          


<210>  570
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  cationic component of the polymeric carrier

<400>  570

Cys Arg Arg Arg Arg Arg Arg Arg Arg Arg Arg Arg Cys 
1               5                   10              


<210>  571
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  cationic component of the polymeric carrier

<400>  571

Cys Arg Arg Arg Arg Arg Arg Arg Arg Arg Arg Arg Arg Arg Cys 
1               5                   10                  15  


<210>  572
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  cationic component of the polymeric carrier

<400>  572

Cys Arg Arg Arg Arg Arg Arg Arg Arg Arg Arg Arg Arg Arg Arg Cys 
1               5                   10                  15      


<210>  573
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  cationic component of the polymeric carrier

<400>  573

Cys Arg Arg Arg Arg Arg Arg Arg Arg Arg Arg Arg Arg Arg Arg Arg 
1               5                   10                  15      


Cys 
    


<210>  574
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  cationic component of the polymeric carrier

<400>  574

Cys Arg Arg Arg Arg Arg Arg Arg Arg Arg Arg Arg Arg Arg Arg Arg 
1               5                   10                  15      


Arg Cys 
        


<210>  575
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  cationic component of the polymeric carrier

<400>  575

Cys Arg Arg Arg Arg Arg Arg Arg Arg Arg Arg Arg Arg Arg Arg Arg 
1               5                   10                  15      


Arg Arg Cys 
            


<210>  576
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  cationic component of the polymeric carrier

<400>  576

Cys Arg Arg Arg Arg Arg Arg Arg Arg Arg Arg Arg Arg Arg Arg Arg 
1               5                   10                  15      


Arg Arg Arg Cys 
            20  


<210>  577
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  cationic component of the polymeric carrier

<400>  577

Cys Arg Arg Arg Arg Arg Arg Arg Arg Arg Arg Arg Arg Arg Arg Arg 
1               5                   10                  15      


Arg Arg Arg Arg Cys 
            20      


<210>  578
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  cationic component of the polymeric carrier

<400>  578

Cys Arg Arg Arg Arg Arg Arg Arg Arg Arg Arg Arg Arg Arg Arg Arg 
1               5                   10                  15      


Arg Arg Arg Arg Arg Cys 
            20          


<210>  579
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  cationic component of the polymeric carrier

<400>  579

Cys Arg Arg Arg Arg Arg Arg Arg Arg Arg Arg Arg Arg Cys 
1               5                   10                  


<210>  580
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  cationic component of the polymeric carrier

<400>  580

Cys Arg Arg Arg Arg Arg Arg Arg Arg Arg Arg Arg Arg 
1               5                   10              


<210>  581
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  cationic component of the polymeric carrier

<400>  581

Cys Arg Arg Arg Arg Arg Arg Arg 
1               5               


<210>  582
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  cationic component of the polymeric carrier

<400>  582

Cys Arg Arg Arg Arg Arg Arg Arg Arg 
1               5                   


<210>  583
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  cationic component of the polymeric carrier

<400>  583

Cys Arg Arg Arg Arg Arg Arg Arg Arg Arg 
1               5                   10  


<210>  584
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  cationic component of the polymeric carrier

<400>  584

Cys Arg Arg Arg Arg Arg Arg Arg Arg Arg Arg 
1               5                   10      


<210>  585
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  cationic component of the polymeric carrier

<400>  585

Cys Arg Arg Arg Arg Arg Arg Arg Arg Arg Arg Arg 
1               5                   10          


<210>  586
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  cationic component of the polymeric carrier

<400>  586

Cys Arg Arg Arg Arg Arg Arg Arg Arg Arg Arg Arg Arg Arg 
1               5                   10                  


<210>  587
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  cationic component of the polymeric carrier

<400>  587

Cys Arg Arg Arg Arg Arg Arg Arg Arg Arg Arg Arg Arg Arg Arg 
1               5                   10                  15  


<210>  588
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  cationic component of the polymeric carrier

<400>  588

Cys Arg Arg Arg Arg Arg Arg Arg Arg Arg Arg Arg Arg Arg Arg Arg 
1               5                   10                  15      


<210>  589
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  cationic component of the polymeric carrier

<400>  589

Cys Arg Arg Arg Arg Arg Arg Arg Arg Arg Arg Arg Arg Arg Arg Arg 
1               5                   10                  15      


Arg 
    


<210>  590
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  cationic component of the polymeric carrier

<400>  590

Cys Arg Arg Arg Arg Arg Arg Arg Arg Arg Arg Arg Arg Arg Arg Arg 
1               5                   10                  15      


Arg Arg 
        


<210>  591
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  cationic component of the polymeric carrier

<400>  591

Cys Arg Arg Arg Arg Arg Arg Arg Arg Arg Arg Arg Arg Arg Arg Arg 
1               5                   10                  15      


Arg Arg Arg 
            


<210>  592
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  cationic component of the polymeric carrier

<400>  592

Cys Arg Arg Arg Arg Arg Arg Arg Arg Arg Arg Arg Arg Arg Arg Arg 
1               5                   10                  15      


Arg Arg Arg Arg 
            20  


<210>  593
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  cationic component of the polymeric carrier

<400>  593

Cys Arg Arg Arg Arg Arg Arg Arg Arg Arg Arg Arg Arg Arg Arg Arg 
1               5                   10                  15      


Arg Arg Arg Arg Arg 
            20      


<210>  594
<211>  1621
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  SP_Ipilimumab-HC

<400>  594
gggagaaagc uuaccaugga gcugggccuc agcuggaucu uccugcuggc cauccucaag       60

ggggugcagu gccaggugca gcuggucgag agcggcgggg gcguggugca gcccgggcgc      120

ucccuccggc ugagcugcgc cgccuccggc uucaccuuca gcuccuacac caugcacugg      180

guccgccagg cgccggggaa gggccuggag ugggugacgu ucaucagcua cgacggcaac      240

aacaaguacu acgccgacuc cgugaagggg cgguucacca ucagccgcga caacuccaag      300

aacacccucu accugcagau gaacagccug cgggccgagg acaccgccau cuacuacugc      360

gcccgcacgg gcuggcucgg gcccuucgac uacuggggcc aggggacccu ggucaccgug      420

uccagcgcgu ccaccaaggg ccccagcgug uucccccugg ccccguccag caaguccacg      480

agcggcggga ccgccgcccu cggcugccug gucaaggacu acuuccccga gcccgugacc      540

guguccugga acagcggggc gcugaccagc ggcguccaca cguuccccgc cgugcuccag      600

uccagcggcc uguacucccu gagcuccgug gucaccgugc cgagcuccag ccucgggacc      660

cagaccuaca ucugcaacgu gaaccacaag cccuccaaca cgaaggucga caagcgggug      720

gagcccaaga gcugcgacaa gacccacacg ugcccgcccu gccccgcccc cgagcugcug      780

ggcgggcccu ccguguuccu cuucccgccc aagcccaagg acacccugau gaucagccgc      840

acccccgagg ugaccugcgu cguggucgac gugucccacg aggacccgga ggucaaguuc      900

aacugguacg uggacggcgu ggagguccac aacgccaaga ccaagccccg ggaggagcag      960

uacaacagca ccuaccgcgu gguguccguc cugacggugc uccaccagga cuggcugaac     1020

gggaaggagu acaagugcaa ggugagcaac aaggcccugc ccgcgcccau cgagaagacc     1080

aucuccaagg ccaagggcca gccgcgggag ccccaggucu acacccuccc gcccagccgc     1140

gacgagcuga ccaagaacca ggugucccug acgugccucg ugaagggcuu cuaccccagc     1200

gacaucgccg ucgaguggga gagcaacggg cagcccgaga acaacuacaa gaccacgccc     1260

ccggugcugg acuccgacgg cagcuucuuc cuguacucca agcucaccgu ggacaagagc     1320

cgguggcagc aggggaacgu cuucuccugc agcgugaugc acgaggcccu gcacaaccac     1380

uacacccaga agucccugag ccucuccccc ggcaagugag gacuaguuau aagacugacu     1440

agcccgaugg gccucccaac gggcccuccu ccccuccuug caccgagauu aauaaaaaaa     1500

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaugc     1560

aucccccccc cccccccccc cccccccccc cccaaaggcu cuuuucagag ccaccagaau     1620

u                                                                     1621


<210>  595
<211>  925
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  SP_Ipilimumab-LC

<400>  595
gggagaaagc uuaccaugga gacccccgcc cagcugcucu uccugcugcu ccuguggcug       60

ccggacacca cgggcgagau cgugcugacc cagagccccg gcacccucuc ccugagcccg      120

ggggagcgcg ccacgcuguc cugccgggcc agccaguccg ucggcagcuc cuaccucgcg      180

ugguaccagc agaagcccgg gcaggcgccc cgccugcuga ucuacggcgc cuucagccgg      240

gccaccggga uccccgaccg cuucuccggc agcggcuccg ggaccgacuu cacccucacg      300

aucagccggc uggagccgga ggacuucgcc guguacuacu gccagcagua cggcuccagc      360

cccuggaccu ucgggcaggg caccaaggug gagaucaagc gcaccgucgc cgcccccucc      420

guguucaucu ucccgcccag cgacgagcag cugaaguccg ggacggccag cguggucugc      480

cuccugaaca acuucuaccc ccgggaggcc aaggugcagu ggaaggugga caacgcgcug      540

caguccggca acagccagga gagcgucacc gagcaggacu ccaaggacag caccuacucc      600

cucagcucca cccugacgcu gagcaaggcc gacuacgaga agcacaaggu guacgccugc      660

gaggugaccc accagggccu cuccagcccc gucaccaagu ccuucaaccg cggggagugc      720

ugaggacuag uuauaagacu gacuagcccg augggccucc caacgggccc uccuccccuc      780

cuugcaccga gauuaauaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa      840

aaaaaaaaaa aaaaaaaaaa augcaucccc cccccccccc cccccccccc cccccccaaa      900

ggcucuuuuc agagccacca gaauu                                            925


<210>  596
<211>  1003
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Hs_CD40LG_v1(GCv3).1

<400>  596
gggagaaagc uuaccaugau cgagaccuac aaccagacca gcccccgcuc cgccgccacg       60

ggccugccga ucagcaugaa gaucuucaug uaccuccuga ccguguuccu gaucacccag      120

augaucgggu ccgcgcuguu cgccgucuac cugcaccggc gccuggacaa gaucgaggac      180

gagcggaacc uccacgagga cuucguguuc augaagacca uccagcgcug caacacgggc      240

gagcggagcc ugucccugcu caacugcgag gagaucaaga gccaguucga gggguucgug      300

aaggacauca ugcugaacaa ggaggagacc aagaaggaga acuccuucga gaugcagaag      360

ggcgaccaga acccccagau cgccgcccac gucaucagcg aggccuccag caagaccacc      420

uccgugcugc agugggcgga gaagggguac uacacgauga gcaacaaccu cgugacccug      480

gagaacggca agcagcugac cgucaagcgc cagggccucu acuacaucua cgcccaggug      540

accuucugcu ccaaccggga ggccagcucc caggcccccu ucaucgcgag ccugugccug      600

aagucccccg ggcgcuucga gcggauccuc cugcgcgccg ccaacacgca cagcuccgcc      660

aagccgugcg gccagcagag cauccaccuc gggggcgugu ucgagcucca gcccggggcc      720

agcgucuucg ugaacgugac cgaccccucc caggucagcc acggcaccgg cuucaccucc      780

uucgggcugc ugaagcucug aggacuaguu auaagacuga cuagcccgau gggccuccca      840

acgggcccuc cuccccuccu ugcaccgaga uuaauaaaaa aaaaaaaaaa aaaaaaaaaa      900

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaau gcaucccccc cccccccccc      960

cccccccccc cccccaaagg cucuuuucag agccaccaga auu                       1003


<210>  597
<211>  667
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  PDCD1(21-150)

<400>  597
gggagaaagc uuaccaugca gaucccccag gccccguggc ccguggucug ggccgugcug       60

cagcucggcu ggcgccccgg gugguuccug gacagccccg accggccgug gaacccgccc      120

accuucuccc ccgcgcugcu cguggucacc gagggcgaca acgccacguu cacgugcagc      180

uucuccaaca ccagcgaguc cuucgugcug aacugguacc gcaugagccc cuccaaccag      240

accgacaagc uggccgccuu ccccgaggac cggagccagc ccgggcagga cugccgcuuc      300

cgggugaccc agcuccccaa cggccgcgac uuccacaugu ccgucgugcg ggcccgccgg      360

aacgacagcg ggaccuaccu gugcggcgcg aucucccugg ccccgaaggc ccagaucaag      420

gagagccucc gcgccgagcu gcgggugacc gagcgccggg cgugaggacu aguuauaaga      480

cugacuagcc cgaugggccu cccaacgggc ccuccucccc uccuugcacc gagauuaaua      540

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa      600

aaaugcaucc cccccccccc cccccccccc ccccccccca aaggcucuuu ucagagccac      660

cagaauu                                                                667


<210>  598
<211>  1849
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  IL12B(1-328)_Linker_IL12A(23-219)

<400>  598
gggagaaagc uuaccaugug ccaccagcag cuggugauca gcugguucuc ccucgucuuc       60

cuggccagcc cccugguggc caucugggag cucaagaagg acguguacgu cguggagcug      120

gacugguacc cggacgcgcc cggcgagaug gugguccuga ccugcgacac ccccgaggag      180

gacgggauca cguggacccu cgaccagucc agcgaggugc ugggcuccgg gaagacccug      240

accauccagg ugaaggaguu cggcgacgcc gggcaguaca cgugccacaa gggcggcgag      300

guccucagcc acucccugcu gcuccugcac aagaaggagg acgggaucug gagcaccgac      360

auccugaagg accagaagga gcccaagaac aagaccuucc uccgcugcga ggccaagaac      420

uacuccggcc gguucacgug cugguggcug accaccauca gcaccgaccu gaccuucucc      480

gucaagagcu cccgcgggag cuccgacccg cagggcguga cgugcggggc cgccacccuc      540

agcgcggagc gggugcgcgg cgacaacaag gaguacgagu acuccgugga gugccaggag      600

gacagcgccu gccccgccgc cgaggagucc cugcccaucg aggugauggu cgacgcggug      660

cacaagcuga aguacgagaa cuacaccagc agcuucuuca uccgggacau caucaagccc      720

gacccgccca agaaccucca gcugaagccc cugaagaacu cccgccaggu ggaggucagc      780

ugggaguacc ccgacaccug guccacgccg cacagcuacu ucucccucac cuucugcguc      840

caggugcagg gcaagagcaa gcgggagaag aaggaccgcg uguucaccga caagaccucc      900

gccacgguga ucugccggaa gaacgccagc aucuccgugc gcgcccagga ccgguacuac      960

agcuccagcu gguccgagug ggccagcguc cccugcuccg gcaguacuuc gggcaguggu     1020

aagccuggua guggugaggg uaguacuaag ggucggaacc ugccgguggc cacccccgac     1080

cccggcaugu uccccugccu gcaccacagc cagaaccucc ugcgcgccgu guccaacaug     1140

cugcagaagg cccggcagac gcucgaguuc uacccgugca ccagcgagga gaucgaccac     1200

gaggacauca ccaaggacaa gaccuccacg gucgaggccu gccugccccu ggagcucacc     1260

aagaacgaga gcugccugaa cucccgcgag accagcuuca ucaccaacgg guccugccug     1320

gcgagccgga agacguccuu caugauggcc cucugccuga gcuccaucua cgaggaccug     1380

aagauguacc agguggaguu caagaccaug aacgccaagc uccugaugga ccccaagcgc     1440

cagaucuucc uggaccagaa caugcucgcc gugaucgacg agcugaugca ggcgcugaac     1500

uucaacagcg agaccguccc ccagaagucc agccucgagg agccggacuu cuacaagacc     1560

aagaucaagc ugugcauccu gcuccacgcc uuccggaucc gcgccgugac gaucgaccgg     1620

gugauguccu accugaacgc cagcugagga cuaguuauaa gacugacuag cccgaugggc     1680

cucccaacgg gcccuccucc ccuccuugca ccgagauuaa uaaaaaaaaa aaaaaaaaaa     1740

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaugcau cccccccccc     1800

cccccccccc cccccccccc caaaggcucu uuucagagcc accagaauu                 1849


<210>  599
<211>  867
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  PDCD1

<400>  599
augcaaaucc cccaagcccc cuggcccgua guaugggccg uacuccagcu cggcuggcga       60

cccggcuggu uccucgacuc ccccgaccgc cccuggaacc cacccacauu cucacccgca      120

cuacucguag ucaccgaagg cgacaacgcc accuucaccu gcuccuucuc caacaccucg      180

gaauccuuug uacucaacug guaccgcaug agcccgucca accaaaccga caaacucgcc      240

gcauuccccg aagaccgcag ccaacccgga caagacugcc gauuccgcgu cacccaacua      300

ccuaacggua gagacuucca caugucaguc guccgcgccc gccgaaacga cuccgguacc      360

uaccuaugcg gagccauauc ccuugccccc aaagcacaaa ucaaagaauc ccuacgagcc      420

gaacuccgag ucaccgaacg ccgagccgaa gucccaaccg cacaccccuc ccccuccccc      480

cgaccagccg gccaauucca aacccuagua gucggcguag uaggcggccu ccuaggcuca      540

cucguacucc ucgucugggu acuagcaguc aucugcucac gagccgcccg aggcaccauc      600

ggagcccgac gaaccggcca accacucaaa gaagaccccu ccgccguacc agucuucuca      660

gucgacuacg gugaacucga cuuucaaugg agagaaaaaa cccccgaacc cccagucccc      720

ugcguccccg aacaaaccga auacgccaca aucgucuucc caucaggcau gggcaccuca      780

ucccccgccc gccgaggcuc cgccgacgga ccccgcuccg cccaaccccu ccgacccgaa      840

gacggccacu gcuccuggcc ccucuaa                                          867


<210>  600
<211>  450
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  PDCD1(1-149)

<400>  600
augcaaaucc cccaagcccc cuggcccguc gucugggccg uccuccaacu cggcuggcga       60

cccggcuggu uccucgacuc ccccgaccgc cccuggaacc cucccaccuu cucccccgcc      120

cuccucgucg ucaccgaagg cgacaacgcc accuucacau gcuccuucuc caacaccucc      180

gaauccuucg uccucaacug guaccgcaug ucccccucca accaaaccga caaacucgcc      240

gccuuccccg aagaccgcuc acaacccggc caagacugcc gcuuccgagu cacccaacua      300

cccaacggcc gcgacuucca cauguccguc guccgcgccc gacgcaacga cuccggcacc      360

uaccuaugcg gcgccaucuc ccucgccccc aaagcccaaa ucaaagaauc ccuccgcgcc      420

gaacuacgug ucaccgaacg ccgagccuaa                                       450


<210>  601
<211>  660
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  IL12A

<400>  601
augugccccg cccgcucccu ccuccucguc gccacacucg uccuccucga ucaccucuca       60

cucgcacgaa accuaccagu cgccaccccc gaccccggca uguuccccug ccuccaccac      120

ucccaaaacc uccuccgcgc cgucuccaau augcuccaaa aagcccgcca aacccucgaa      180

uucuaccccu gcacauccga agaaaucgac cacgaagaca ucaccaaaga caaaaccucc      240

accgucgaag ccugccuccc ccuugaacuc accaaaaacg aauccugccu aaacucacgc      300

gaaaccuccu ucaucaccaa cggaucaugc cucgccuccc gcaaaaccuc cuucaugaug      360

gcccucugcc ucuccuccau cuacgaagac cucaaaaugu accaaguaga auucaaaacc      420

augaacgcca aacuccucau ggaccccaaa cgccaaaucu uccucgacca aaacaugcuc      480

gccgucaucg acgaacucau gcaagcccuc aacuucaacu cagaaaccgu cccccaaaaa      540

ucaucccucg aagaacccga cuucuacaaa accaaaauca aacuaugcau cuuacuccac      600

gccuuccgga ucagagcagu caccaucgac cgcgucaugu ccuaccuaaa cgccuccuaa      660


<210>  602
<211>  657
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  IL12A(1-219)

<400>  602
augugccccg cccgcucucu ccuccucgua gcaacccucg uccuccucga ccaccucucc       60

cuagcccgaa accuccccgu cgccaccccc gacccaggca uguuccccug ccuccaccac      120

ucccaaaacc uccuccgagc cgucuccaac augcuccaaa aagcccgcca aacccucgaa      180

uucuaccccu gcaccuccga agaaaucgac cacgaagaca ucaccaaaga caaaaccucc      240

accgucgaag ccugccuccc ccucgaacuc accaaaaacg aaucaugccu caacucccgc      300

gaaaccuccu ucaucaccaa cggcuccugc cuagccuccc gcaaaaccuc cuucaugaug      360

gcccucugcc ucucauccau cuacgaagac cuaaaaaugu accaagucga auucaaaacc      420

augaacgcca aacuccucau ggacccaaaa cgccaaaucu uccuagacca aaacaugcuc      480

gccgucaucg acgaacucau gcaagcccuc aacuucaacu ccgaaaccgu accccaaaaa      540

uccucacucg aagaacccga cuucuacaaa acaaaaauca aacucugcau acuccuccac      600

gccuuccgca uccgcgccgu caccaucgau cgagucaugu ccuaccucaa cgccucc         657


<210>  603
<211>  594
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  IL12A(23-219)

<400>  603
cgcaaccucc ccgucgccac ccccgacccc ggcauguucc ccugccucca ccacucccaa       60

aaucuccucc gcgccgucuc caacaugcuc caaaaagccc gccaaacccu cgaauucuac      120

cccugcacgu ccgaagaaau cgaccacgaa gacaucacca aagacaaaac cuccaccguc      180

gaagccugcc ucccccucga acucaccaaa aacgaauccu gccucaacuc acgcgaaacc      240

uccuucauca ccaacggcuc augccucgcc ucacgaaaaa ccuccuucau gauggcccuc      300

ugccucuccu caaucuacga agaccucaaa auguaccaag ucgaauucaa aaccaugaac      360

gccaaacucc ucauggaccc caaacgccaa aucuuccucg accaaaacau gcucgcaguc      420

aucgacgaac ucaugcaagc ccucaacuuc aacuccgaaa ccguccccca aaaaucaucc      480

cucgaagaac cagacuucua caaaaccaaa aucaaacucu gcauccuccu ccacgccuuc      540

cgcauccgcg ccguaaccau cgaccgcguc augucauacc ucaacgccuc cuaa            594


<210>  604
<211>  987
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  IL12B

<400>  604
augugccacc aacaacucgu caucuccugg uucucccucg ucuuccucgc cucuccccuc       60

gucgccauau gggaacucaa gaaggacguc uacguaguag aacucgacug guacccagac      120

gcccccggag aaaugguggu ccucaccugc gacacccccg aagaagacgg caucaccugg      180

acauuagacc aaucguccga aguucucggc uccggcaaaa cacucacaau ccaaguaaaa      240

gaauucggcg acgccggaca auacaccugc cacaaaggcg gagaaguacu aucccacuca      300

cuccuacucc uacacaaaaa agaagacggc auauggagca ccgacauccu caaagaccaa      360

aaagaaccca aaaacaaaac cuuccuccga ugcgaagcca aaaacuacuc cggccgcuuc      420

accugcuggu ggcucaccac aauauccacc gaccucaccu ucuccgucaa aucaucucgc      480

ggcuccagcg acccccaagg cgucaccugc ggcgccgcca cccucucagc cgaacgcgua      540

cgcggugaca acaaagaaua cgaauacagc guagaaugcc aagaagacuc cgccuguccc      600

gccgcagaag aaucacuccc caucgaaguc augguagacg caguacacaa acucaaauac      660

gaaaacuaca ccuccuccuu cuucauccgc gacaucauca aacccgaccc cccaaaaaac      720

cuacaacuca aaccccuuaa aaacucccgc caagucgaag ucuccuggga auacccagac      780

acauggucca ccccccacuc cuacuucucc cucaccuucu gcguccaagu ccaaggcaaa      840

uccaaacgcg aaaaaaaaga ccgaguauuc accgacaaaa ccucagccac cgucaucugc      900

agaaaaaacg ccuccaucuc cguccgagcc caagaccgcu acuacuccuc cuccuggucc      960

gaaugggcau ccguccccug cucauaa                                          987


<210>  605
<211>  984
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  IL12B(1-328)

<400>  605
augugccacc aacaacucgu caucagcugg uucagccucg ucuuccucgc cuccccccua       60

guagccauau gggaacuaaa aaaagacgua uacguuguag aacuagacug guaccccgac      120

gcacccggcg aaauggucgu ccucaccugc gacacccccg aagaagaugg cauaacaugg      180

acccucgacc aauccucaga aguccucggc uccggcaaaa cccucacaau ccaagucaaa      240

gaauucggcg acgccggcca auacaccugc cacaaaggcg gcgaaguccu cucucacucu      300

cuccuccucc uccacaaaaa agaagacggc aucuggucca ccgacauacu caaagaccaa      360

aaagaaccca aaaacaaaac cuuccugcga ugcgaagcca aaaacuacuc cggccgauuc      420

acaugcuggu ggcucaccac caucucaacc gaccucaccu ucuccgucaa auccucccgu      480

ggcagcuccg acccccaagg agucaccugc ggcgcagcca cccucuccgc cgaacgcguc      540

agaggcgaca acaaagaaua cgaauacucc gucgaaugcc aagaggacuc cgccugcccc      600

gccgccgaag aaucacuccc caucgaaguc augguagacg ccguacacaa acuaaaauac      660

gaaaacuaca ccucuucauu cuucauccga gacaucauca aacccgaccc ccccaaaaac      720

cuccaacuca aaccccucaa aaacucccga caagucgaag ucagcuggga auacccagac      780

accuggucca ccccacacuc cuacuucuca cuaaccuucu gcguccaagu ccaaggcaaa      840

ucgaaacgcg aaaaaaaaga cagagucuuc accgacaaaa ccucagccac cgucaucugc      900

cgaaaaaacg caucaaucag cguccgcgcc caagaccgcu acuacuccuc cagcuggagc      960

gaaugggcau ccguccccug cucc                                             984


<210>  606
<211>  921
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  IL12B(23-328)

<400>  606
aucugggaac ucaaaaaaga cgucuacgua gucgaacucg acugguaccc agacgccccc       60

ggcgaaaugg ucguccucac cugcgacaca cccgaagaag acggcaucac cuggacacuc      120

gaccaauccu ccgaaguacu cggcuccggc aaaacccuca caauccaagu caaagaauuc      180

ggcgacgccg gccaauacac cugccacaaa ggcggcgaag uccucuccca cucccuccuc      240

cuacuccaca aaaaagaaga cggcaucugg uccacagaca uccucaaaga ccagaaagaa      300

cccaaaaaca agaccuuccu acgaugcgaa gccaaaaacu acagcggccg auucaccugc      360

ugguggcuca caaccaucag caccgaccua accuucuccg uaaaauccuc cagaggaucc      420

agcgaccccc aaggcgucac augcggcgcc gcaacccuau ccgcagagcg aguacgaggc      480

gacaacaaag aauacgaaua cuccguagaa ugccaagaag acuccgcaug cccugccgcc      540

gaagaaagcc uccccaucga agucaugguc gacgcagucc acaaacucaa auacgaaaac      600

uacacaagcu cuuucuucau acgcgacauc aucaaacccg accccccaaa aaaccuacaa      660

cucaaacccc uaaaaaacuc ccggcaaguc gaagucagcu gggaauaccc cgacaccugg      720

uccacccccc auuccuacuu cucccucaca uucugcguac aaguccaagg caaaaguaaa      780

cgcgagaaaa aagaccgcgu cuucaccgac aaaaccagcg caaccgucau cugccgcaaa      840

aacgccagca ucagcguacg agcccaagac cgcuacuacu caagcucaug guccgaaugg      900

gccuccgucc ccugcucaua a                                                921


<210>  607
<211>  54
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Linker-sFvCC49-218

<400>  607
gggaguacga gugggagugg gaagccgggg aguggggagg ggaguacgaa gggg             54


<210>  608
<211>  1632
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  IL12

<400>  608
augugccacc aacaacucgu gaucuccugg uucucccucg uuuuccucgc aucaccccuc       60

guugcuauau gggaacucaa gaaagacguc uacgucgucg aacucgacug guacccggac      120

gcccccggcg aaauggucgu ccuaaccugc gauacacccg aagaagacgg caucaccugg      180

acccucgacc aguccucuga aguccuagga uccggcaaaa cccuuacaau ccaagucaaa      240

gaguucggcg acgccggcca guacacaugc cacaaaggcg gcgagguccu gagccauucc      300

uuacuccucc uacacaagaa agaagacggc aucuggucca ccgacauacu aaaagaccaa      360

aaagaaccca aaaacaaaac cuuccuacga ugcgaagcca aaaacuacuc aggccgauuc      420

accuguuggu ggcucaccac gaucagcacc gaccuaacau ucucaguaaa auccucacgc      480

ggcuccagcg acccacaagg cgucacaugc ggggccgcca cccuauccgc cgaacgaguc      540

aggggcgaca acaaagaaua cgaauacagc guagaaugcc aagaagacuc cgccugcccc      600

gcggccgaag agucccuacc cauagagguc auggucgacg ccguccacaa acucaaauac      660

gagaacuaca ccuccagcuu cuucauccgc gacauaauca aaccagaccc acccaaaaac      720

cuacaacuaa aaccacucaa aaauucgcgc caggucgaag ucucuuggga auacccggac      780

accuggucaa ccccacacuc cuacuucagc cuaaccuucu gcguccaagu ccaaggcaaa      840

uccaaacgcg aaaagaaaga ccgaguauuc acagacaaaa ccucagcaac gguaaucugc      900

cgcaaaaacg ccuccaucuc agucagggcc caagaccgau acuacuccuc cucauggagc      960

gagugggcau cuguaccaug cagcgggagc acauccggau ccggaaaacc cggcuccggc     1020

gaaggaagca ccaaagguag aaaccuucca guagccaccc ccgacccugg uauguuuccc     1080

ugccuccacc auagccaaaa ccuccuacga gcagucucca acaugcucca aaaagcacga     1140

caaacccuug aguucuaccc augcacaucc gaagaaauag accacgaaga caucacaaag     1200

gacaaaaccu ccacagucga agccugccuc ccacuugaac ucaccaaaaa cgaaucaugc     1260

cuaaacuccc gcgaaaccuc uuucaucacc aauggaucau gccucgcauc ccgcaaaaca     1320

ucguucauga uggcacucug ccugucaagc aucuacgaag accucaaaau guaccaaguu     1380

gaguucaaga caaugaacgc aaaacuccuc auggacccua aacgccaaau auuccucgac     1440

caaaacaugc ucgccgugau agacgaacuc augcaagcac uaaacuucaa cagcgaaaca     1500

gucccccaaa aauccagccu cgaagaaccc gacuucuaca aaaccaaaau caaacuaugc     1560

auccuccucc acgccuucag aaucagggcc gugaccaucg acagagucau guccuaccuc     1620

aacgccucgu aa                                                         1632


<210>  609
<211>  786
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  CD40LG

<400>  609
augaucgaaa cauacaacca aacauccccc cgauccgccg caacaggccu ccccaucucc       60

augaaaauau ucauguaccu ccucacagua uuccucauaa cccaaaugau cggaucagca      120

cuauucgccg ucuaccucca ccgccgccuc gacaaaaucg aagacgaacg caaccuccac      180

gaagacuucg ucuucaugaa aaccauccaa cgcugcaaca ccggagaacg aucccuaucc      240

cuccucaacu gcgaagagau caaaucccaa uucgaaggcu ucgucaaaga caucaugcuc      300

aacaaagaag aaaccaaaaa agaaaacucc uucgaaaugc aaaaaggcga ccaaaacccc      360

caaaucgccg cccacgucau cuccgaagcc uccuccaaaa caaccuccgu ucuccaaugg      420

gccgagaaag gcuacuacac uauguccaac aaccucguca cccucgaaaa cggcaaacaa      480

cucaccguca aacgccaagg ccucuacuac aucuacgccc aagucacauu cugcuccaac      540

cgcgaagcau ccagccaagc ccccuucauc gccucacucu gccucaaauc ccccggccga      600

uucgaacgca uccuccuacg cgccgccaac acccacuccu cagccaaacc cugcggccaa      660

caauccaucc accuaggcgg cgucuucgaa cuccaacccg gugccuccgu cuuugucaac      720

guaaccgacc ccucccaagu cucccacggc accggauuca cauccuucgg ccuccucaaa      780

cucuaa                                                                 786


<210>  610
<211>  867
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  PDCD1

<400>  610
augcagauac cacaagcacc auggccagua guaugggcag uauuacaauu aggauggaga       60

ccaggauggu uuuuagacuc accagauaga ccauggaauc caccaacauu uucaccagca      120

uuauuagucg uaacagaagg agacaaugca acauuuacau guucauuuuc aaauacauca      180

gaaucuuuug uauuaaauug guauagaaug ucaccaagua aucaaacaga uaaauuagca      240

gcauuuccag aagauagauc acaaccagga caagauugua gauuuagagu aacacaauua      300

ccuaauggua gagauuuuca uaugucagua guaagagcaa gacgaaauga uagcggaaca      360

uauuuaugug gagcaauauc auuagcacca aaagcacaaa uaaaagaaag uuuaagagca      420

gaacuaagag uaacagaaag aagagcagaa guaccaacag cacauccauc uccaagucca      480

agaccagcag gacaauuuca aacauuagua guuggaguag uaggaggacu acuaggauca      540

uuaguauuac uaguaugggu acuagcugua auauguucaa gagcagcaag aggaacaaua      600

ggugcaagaa gaacaggaca accacuuaaa gaagacccuu cagccguacc uguauuuagu      660

guagauuaug gagaauuaga uuuccaaugg agagaaaaaa caccagaacc accuguacca      720

ugcguaccag aacaaacaga auacgcaaca auaguuuucc caucaggaau gggaacuagc      780

ucacccgcaa gaagaggauc agcagaugga ccaagaucag cacaaccacu aagacccgaa      840

gauggacauu guucauggcc auuauaa                                          867


<210>  611
<211>  450
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  PDCD1(1-149)

<400>  611
augcaaauac cccaagcacc auggccagua guaugggcag uauuacaacu aggauggaga       60

ccaggauggu ucuuagacuc accagacaga ccauggaacc caccaacauu cucaccagca      120

cuauuaguag uaacagaagg agacaacgca acauucacau gcucauucuc aaacacauca      180

gaaucauucg uauuaaacug guacagaaug ucaccaucaa accaaacaga caaacuagca      240

gcauucccag aagacagauc acaaccagga caagacugca gauucagagu aacacaacua      300

ccaaacggaa gagacuucca caugucagua guaagagcaa gaagaaacga cucaggcacc      360

uaccuaugcg gagcaauauc acuagcacca aaagcacaaa uaaaagaauc acuaagagca      420

gaacuaagag uaacagaaag acgagcauaa                                       450


<210>  612
<211>  660
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  IL12A

<400>  612
augugcccag caagaucacu acuacuagua gcaacacuag uacuacuaga ccaccuaucc       60

cuagcacgaa accuaccagu agcaacaccu gacccaggaa uguucccaug ccuccaccac      120

ucccaaaacc uauuacgagc agucucaaac augcuacaaa aagcacgaca aacacuagaa      180

uucuacccau gcacaucaga agaaauagac cacgaagaca uaacaaaaga caaaacauca      240

acaguagaag caugccuacc acuagaacuc acaaaaaacg aaucaugccu aaacucuaga      300

gaaacaucau ucauaacaaa cggaucaugc cuagccucca gaaaaacauc auucaugaug      360

gccuuaugcc uaucaucaau auaugaagac cuaaaaaugu accaagucga auucaaaaca      420

augaacgcaa aacuacuaau ggacccaaaa agacaaauau uccuagacca aaacaugcuc      480

gcaguaauag augaacuaau gcaagcacua aacuucaacu cagaaaccgu cccccaaaaa      540

uccucacuag aagaacccga cuucuacaaa acaaaaauaa aauuaugcau acuauuacac      600

gcauuuagaa uaagagcagu aacaauagac agaguaaugu cauaccuaaa cgcauccuaa      660


<210>  613
<211>  657
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  IL12A(1-219)

<400>  613
augugcccag caagaucauu acuacuagua gccacacuag uccuccuaga ccaccuauca       60

cuagcaagaa accuaccagu agcaacacca gacccaggaa uguucccaug ccuacaccac      120

ucacaaaacu uacuaagagc aguaucaaac augcuacaaa aagcaagaca aacacuagaa      180

uucuacccau gcacaucaga agaaauagau caugaagaca uaacaaaaga caaaacaucc      240

acaguagaag caugccuacc acuagaacua acaaaaaacg aaucaugccu aaacucacga      300

gaaaccucau ucauaacaaa cggaucaugc cuagcaucac gaaaaaccuc auucaugaug      360

gcacuaugcc uaucauccau auacgaagac cuaaaaaugu accaaguaga auucaaaaca      420

augaacgcaa aacuccucau ggacccaaaa agacaaauau uccuagacca aaacaugcua      480

gcaguuauag acgaacuaau gcaagcacua aacuucaacu cagaaaccgu accacaaaaa      540

ucaucacuag aagaaccaga cuuuuacaaa accaaaauaa aacuaugcau acuacuacac      600

gcauucagaa uaagagcagu aacaauagac agaguaaugu cuuaccuaaa cgcauca         657


<210>  614
<211>  594
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  IL12A(23-219)

<400>  614
agaaaccuac caguagcaac acccgaccca ggaauguucc caugccuaca ccacucacaa       60

aaccuacuac gcgcaguauc aaacauguua caaaaagcac gacaaacacu ugaauucuac      120

cccugcacau cagaagaaau agaccacgaa gacauaacaa aagacaaaac auccaccgua      180

gaagcaugcc ucccacuaga acuaacaaaa aacgaaucau gccuaaacuc aagagaaaca      240

ucauucauaa caaacggauc augccuagca ucacgaaaaa caucauucau gauggcacua      300

ugccuauccu ccauauacga agaccuaaaa auguaccaag uagaauucaa aacaaugaac      360

gcaaaacuac uaauggaccc aaaaagacaa auauuccuag accaaaacau gcucgcagua      420

auagacgaac uaaugcaagc acuaaacuuu aacucagaaa caguacccca aaaaucauca      480

cuagaagaac cagacuucua caaaacaaaa auaaaauuau gcauacuccu acacgcauuc      540

agaaucagag caguaacaau agaccgcgua augucauacc uaaacgcauc auaa            594


<210>  615
<211>  987
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  IL12B

<400>  615
augugccauc aacaacuagu aaucucaugg uucagccuag uauucuuagc caguccauua       60

guagcaauau gggaauuaaa aaaagaugua uacguugugg aacuagacug guauccugac      120

gcaccaggag aaaugguugu acuaacaugu gauacacccg aagaagacgg aauaacaugg      180

acacuagacc aaucaucaga aguauuaggc ucaggaaaaa cauuaacaau acaaguaaaa      240

gaauucggag acgccggaca auacacaugc cacaaaggag gcgaaguauu aucacauuca      300

uuauuacuac uacacaaaaa agaagacggc aucuggucaa cagacauauu aaaagaccaa      360

aaagaaccua aaaacaaaac auucuuaaga ugcgaagcaa aaaacuacag uggaagauuc      420

acaugcuggu ggcugacaac aauaucaaca gaucuaacau uuucaguaaa aucaucaaga      480

ggaucaucag auccacaagg cguaacaugc ggagccgcaa cacuaagcgc agaaagaguc      540

agaggagaca acaaagaaua cgaauauuca guagaauguc aagaagauuc agcaugcccu      600

gcagcagaag aaucacuacc aauagaaguc augguagaug caguacacaa acuaaaauau      660

gaaaacuaca caucaagcuu cuuuauaaga gacauaauca aaccagaccc accaaaaaac      720

cuacaacuaa aaccauuaaa aaacucacga caaguagaag uaagcuggga auacccagac      780

acguggucga ccccacacuc auacuucagc uuaacauuuu gcguacaagu acaaggaaaa      840

ucaaaaagag aaaaaaaaga ccgaguauuu acagacaaaa caucugcaac aguaauaugc      900

cgaaaaaacg caucaauauc uguaagagca caagacagau auuacucauc aucauggagu      960

gaaugggcaa gcguaccaug cucauaa                                          987


<210>  616
<211>  984
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  IL12B(1-328)

<400>  616
augugccauc aacaacuagu aauaucaugg uucucacuag uauucuuagc aaguccccua       60

guagcaauau gggaacuaaa aaaagacguc uacguuguag aauuagacug guacccagac      120

gcaccaggcg aaaugguagu acuaacaugc gauacaccag aagaagacgg aauaacaugg      180

acacuagacc aaucaucaga aguucuagga ucaggaaaaa cauuaacaau acaaguaaaa      240

gaauucgggg acgcaggaca auauacaugc cacaaaggag gagaaguuuu aucacacuca      300

cuacuauuau uacacaaaaa agaagacgga auauggucaa cugacauacu aaaagaucaa      360

aaagaaccaa aaaacaaaac auucuuaaga ugugaagcaa aaaauuacag uggaagauuc      420

acaugcuggu ggcuaacaac aauaaguaca gaccuaacau uuucaguaaa aucaaguaga      480

ggaucaucag acccacaagg cguaacaugu ggagcagcaa cacuaucagc agaacgaguc      540

agaggagaca acaaagaaua cgaauacucc guagaaugcc aagaagacag ugcaugcccc      600

gcagccgaag aaucauuacc aauagaagua augguagacg caguacacaa acuaaaauac      660

gaaaacuaca caagcucauu cuuuauacga gauauaauaa aaccagaccc accaaaaaac      720

cuacaacuaa aaccacuaaa aaacucacgc caaguagaag uauccuggga auacccagau      780

acauggucaa caccacacuc auauuucagc uuaacauucu guguacaagu acaaggaaaa      840

ucaaaaagag aaaaaaaaga uagaguauuc accgacaaga caagcgcaac aguaauuugu      900

agaaaaaacg caucaauauc aguaagagca caagacagau acuacagcuc aagcugguca      960

gaaugggcaa guguaccaug uuca                                             984


<210>  617
<211>  921
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  IL12B(23-328)

<400>  617
auaugggaau uaaaaaaaga cguauacgua guagaacuag auugguaccc agaugcacca       60

ggagaaaugg uuguauuaac augcgacaca ccagaagaag auggaauaac auggacacua      120

gaccaaagua gugaaguacu aggaagcggc aaaacauuaa cuauacaagu aaaagaauuc      180

ggagacgcag gacaauauac augucacaaa ggaggagaag uccuauccca caguuuauua      240

uuauuacaca aaaaagaaga cggaauaugg aguacagaua uacuaaaaga ccaaaaagaa      300

cccaaaaaca aaacauuucu aaggugcgaa gcaaaaaacu auucaggaag auuuacaugu      360

ugguggcuaa cuacaauauc aacagaccuc acauuuucag uaaaauccag uagaggaagu      420

ucagauccac aaggaguaac auguggagca gcaacacuau cagcagaaag aguaagagga      480

gacaauaaag aauaugaaua uucaguagaa ugccaagaag auagcgcuug cccagcagca      540

gaagaaagcc uuccaauaga aguaauggua gacgcaguuc acaaauuaaa auaugaaaau      600

uacaccagcu cauucuuuau aagagacaua auaaaaccag auccaccaaa aaauuuacaa      660

cuaaaaccau uaaaaaauuc aagacaagua gaaguaagcu gggaauaccc agauacaugg      720

agcaccccac acucauacuu cucauuaaca uuuuguguac aaguacaagg aaaaagcaaa      780

agagaaaaaa aagacagggu auucacagau aaaacaagcg caacaguaau auguagaaaa      840

aacgcaucaa uaagcguaag agcacaagau agauauuacu caucaucaug gucagaaugg      900

gcauccguac caugcucaua a                                                921


<210>  618
<211>  54
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Linker-sFvCC49-218

<400>  618
ggaaguacaa guggaagugg aaaaccagga aguggagaag gaaguacaaa agga             54


<210>  619
<211>  1632
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  IL12

<400>  619
augugccacc aacaacuagu uauaucaugg uuuucacuag uauuucuagc cucaccacuc       60

guagccauau gggaacuaaa aaaggacgua uacguuguag aacucgacug guacccagau      120

gcaccaggcg aaaugguagu acuuacaugc gauacacccg aagaagacgg aaucacaugg      180

acauuagauc aaucaucaga aguacuagga uccggcaaaa cauuaacaau acaaguaaaa      240

gaauucggcg augccggaca auauacaugc cacaaaggag gagaaguauu aagucacuca      300

cuacuuuuac uucauaaaaa agaagacggu auuuggucaa cagacauacu uaaagaucaa      360

aaggaaccaa aaaacaaaac auuccuacga ugcgaagcaa agaauuauuc gggccgauuc      420

acaugcuggu ggcuaacaac aauuuccaca gaccuaacau ucucaguuaa guccucaaga      480

ggaaguuccg auccacaagg aguaacaugu ggcgccgcaa cauuaagcgc agaacgcgua      540

agaggagaua acaaagaaua cgaauacuca guagaaugcc aagaggacuc cgccugucca      600

gcagccgaag aaucuuuacc aauagaagua augguagaug caguacauaa acuaaaauac      660

gaaaacuaua cgucaucauu cuuuauaaga gauauaauca aaccagaccc accuaaaaau      720

cuacaacuaa aaccccuaaa aaauucacga caaguagagg uuucauggga auauccagau      780

acauggucaa caccacacag cuacuuuagu uuaacauucu guguacaagu ccagggaaaa      840

ucaaaaagag aaaaaaaaga cagaguauuu accgacaaaa cauccgcaac aguaauaugu      900

agaaaaaaug cauccauauc aguacgagca caagaccgau acuauucauc aaguugguca      960

gaaugggcau caguaccuug cuccggaagu accucaggca guggaaaacc aggaucagga     1020

gaaggaucaa ccaaaggaag aaaccuacca guagcaacac cugacccagg cauguucccu     1080

ugcuuacauc acucacaaaa ccuacuacga gcugugucaa auauguuaca aaaagcaaga     1140

caaaccuuag aauuuuaucc augcacauca gaagaaaucg accaugaaga cauaaccaaa     1200

gacaaaacaa gcacaguuga agccuguuua ccauuagaac ucacgaaaaa cgaauccugu     1260

cucaacucaa gagaaacauc auuuauaaca aauggcucau gccuugccuc acguaaaaca     1320

ucauucauga uggcacuaug ccuuucaucc auauacgaag accuaaaaau guaccaagua     1380

gaauucaaaa caaugaaugc aaaauuacua auggacccaa aaagacaaau auuuuuagac     1440

caaaacaugu uagcaguaau agacgaauua augcaagccu uaaacuucaa uucagaaaca     1500

guaccccaaa aaucaagcuu agaagaacca gacuuuuaua aaacuaaaau aaaacuaugc     1560

auccuauuac acgcuuuuag aauaagagca guuacaauag acagagucau gagcuaucua     1620

aaugcaucau ga                                                         1632


<210>  620
<211>  786
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  CD40LG

<400>  620
augauagaaa cauacaauca aaccucccca agauccgcag caacaggacu accaauauca       60

augaaaauau ucauguacuu acuaacagua uuccucauaa cacaaaugau aggauccgca      120

cuuuucgcag uauaccuaca cagaagauua gacaaaauag aagacgaacg aaaccuacac      180

gaagacuucg uauuuaugaa aacuauacaa cgcugcaaca caggagaaag aucucuaucu      240

cuauuaaacu gcgaagaaau caaaucacaa uuugaaggau uuguaaaaga cauaaugcua      300

aacaaagaag aaaccaaaaa agaaaacuca uucgaaaugc aaaaaggaga ccaaaaccca      360

caaauagcag cccacgucau auccgaagca agcucaaaaa caaccucagu acuacaaugg      420

gcagaaaaag gauacuacac aaugucaaac aaccuaguaa cccuagaaaa cggaaaacaa      480

cuaacaguca aaagacaagg acuauacuac auauacgcac aaguaacauu cugcucaaac      540

agagaagcau caucccaagc acccuucaua gcaucacuau gccucaaauc accaggaaga      600

uucgaacgaa uacuauuaag agcugcaaac acacauucau cagcaaaacc auguggacaa      660

caaucaauac accuaggagg aguauucgaa uuacaaccag gagcaucagu auucguaaau      720

guuacugacc ccucacaagu cucacacgga acaggauuca caucauucgg acuauuaaaa      780

cuauaa                                                                 786


<210>  621
<211>  867
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  PDCD1

<400>  621
augcaaauac cacaagcacc auggccagua guaugggcag uacuacagcu agguuggaga       60

ccaggauggu uucuagauuc accagauaga ccauggaauc caccuacauu uucacccgca      120

uuauuaguag uaacugaagg agacaaugca acauuuacau gcucauuuuc aaauacaucu      180

gaaagcuuug uauuaaauug guauagaaug agccccucaa aucaaacaga uaaauuagca      240

gcauucccag aagauagauc acaacccgga caagauugua gauuuagagu uacacaacua      300

ccaaauggaa gagauuuuca uaugucagua guaagagcaa gaagaaauga uagcggaaca      360

uauuuaugug gagcaauaag cuuagcacca aaagcacaaa uaaaagaaag uuuaagagca      420

gaauuaagag uaacagaaag aagagcagaa guaccaaccg cacauccauc accaagucca      480

agaccagcug gucaauucca aacuuuagua guaggaguag uaggaggacu auuaggaagu      540

uuaguauuau uaguaugggu acuagcagua auauguucaa gagcagcaag aggaacaaua      600

ggugcaagaa gaacaggaca accauuaaaa gaagacccau cagcuguacc aguuuuuuca      660

guagauuaug gagaacuuga uuuucaaugg agagaaaaaa cuccugaacc accaguacca      720

uguguuccag aacaaacuga auaugcuaca auagucuucc caucaggaau gggaacaagu      780

aguccagcca gaagaggauc agcagaugga ccaagaucag cacaaccauu aagaccagaa      840

gacggacacu guagcuggcc acuauaa                                          867


<210>  622
<211>  450
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  PDCD1(1-149)

<400>  622
augcaaauac cacaagcacc auggccagua guaugggcag uacuacaacu aggauggaga       60

ccaggauggu ucuuagacuc accagacaga ccauggaacc caccaacauu cucaccagca      120

cuacuaguag uaacagaagg agauaacgca acauucacau gcucauucag uaacacauca      180

gaaucauucg uauuaaacug guacagaaug ucaccaucaa accaaacaga caaacuagca      240

gcauucccag aagacagauc acaaccagga caagacugca gauucagagu aacacaauua      300

ccaaacggaa gagacuucca caugucagua guaagagcaa gaagaaauga cucaggaaca      360

uaccuaugcg gagcaauauc acuagcacca aaagcacaaa uaaaagaauc acuaagagca      420

gaauuaagag uaacagaaag aagagcauaa                                       450


<210>  623
<211>  660
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  IL12A

<400>  623
augugcccag caagaucacu acucuuagua gcaacacuag ucuuacuaga ccaccuauca       60

cuagcaagaa accuaccagu agcaacacca gacccaggaa uguucccaug ccuacaccau      120

ucacaaaauu uauuaagagc aguauccaac augcuacaaa aagcaagaca aacauuagaa      180

uucuacccau gcacauccga agaaauagac cacgaagaca uaacaaaaga caaaacaucu      240

acaguagaag caugccuacc acuagaacua acaaaaaacg aaucaugccu aaacucaaga      300

gaaacaucau ucaucacaaa cggcuccugc uuagcaucaa gaaaaacauc auucaugaug      360

gcacuaugcc uaucaucaau auacgaagac cuaaaaaugu accaaguaga auucaaaaca      420

augaacgcaa aacuacuaau ggacccaaaa agacaaauau uccuagacca aaacaugcua      480

gcaguaauag augaacuaau gcaagcacua aacuucaacu cagaaacagu accccaaaaa      540

ucaucacuag aagaaccaga cuucuacaaa acaaaaauaa aacucugcau acuacuacac      600

gcauucagaa uaagagccgu aacaauagac agaguaaugu cauaccuaaa cgcaucauaa      660


<210>  624
<211>  657
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  IL12A(1-219)

<400>  624
augugcccag ccagaucacu auuacucgua gcaacauuag uauuacuaga ccaccuauca       60

cuagcaagaa accuacccgu agcaacaccc gacccaggaa uguuccccug ccuacaucac      120

ucccaaaacc uacuaagagc aguaucaaac auguuacaaa aagcacgaca aacacuagaa      180

uucuaccccu gcacaucaga agaaauagac cacgaagaca uaacaaaaga caaaacauca      240

acaguagaag caugccuccc acuagaacua acaaaaaacg aaucaugccu aaacucaaga      300

gaaacaucau ucauaacaaa cggaucaugc cuagcaucaa gaaaaacauc auucaugaug      360

gcacuaugcc uaucaucaau auacgaagac cuaaaaaugu accaaguaga auucaaaaca      420

augaacgcaa aacuauuaau ggacccaaaa agacaaauau uccuagacca aaacaugcuc      480

gcaguaauag acgaacuaau gcaagcacua aacuucaacu ccgaaacagu accccaaaaa      540

ucaucacucg aagaaccaga cuuuuacaaa acaaaaauaa aacuaugcau acuacuacac      600

gcauucagaa uaagagcagu aacaauagac agaguaaugu cauaccuaaa cgccuca         657


<210>  625
<211>  594
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  IL12A(23-219)

<400>  625
agaaaccuac caguagcaac accagacccc ggaauguucc caugccucca ccacucacaa       60

aaccuacuaa gagcaguauc aaacauguua caaaaagcca gacaaacauu agaauuuuac      120

ccauguacau cagaagaaau agaccacgaa gacauaacaa aagacaaaac aucaacagua      180

gaagcaugcc uaccauuaga acuaaccaaa aacgaaucau gccuaaacuc aagagaaaca      240

ucauucauaa caaacggauc augccuagca ucaagaaaaa caucauucau gauggcacua      300

ugccuaucau ccauauacga agaccuaaaa auguaccaag uagaauuuaa aacaaugaac      360

gcaaaacucc uaauggaccc aaaaagacaa auauuccuag accaaaauau gcucgcagua      420

auagacgaau uaaugcaagc acuaaacuuc aacucagaaa caguaccaca aaaaucaucc      480

cuagaagaac ccgacuucua caaaacaaaa auaaaacuau gcauacuacu acacgcauuc      540

agaauaagag ccguaacaau agacagagua augucauacc uaaacgcauc auaa            594


<210>  626
<211>  987
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  IL12B

<400>  626
augugccacc aacaacuagu aaucagcugg uuuucauuag uauuucuagc aucaccacua       60

guagcaauau gggaacuaaa aaaagacgua uacguaguag aacucgacug guacccagac      120

gcaccaggag aaaugguagu acuaacaugc gacacaccag aagaagacgg aauaacaugg      180

acacuagauc aaucaucaga aguacuagga ucagguaaaa cacuaacaau ccaaguaaaa      240

gaauucggag acgcuggaca auacacaugu cacaaaggag gagaaguacu aagccacuca      300

cuauuauuac uacacaaaaa agaagacggc auauggucaa cagacauacu aaaagaccaa      360

aaagaaccaa aaaacaaaac auuucucaga ugcgaagcaa aaaauuacuc aggaagauuc      420

acaugcuggu gguuaacaac aauaucaaca gaucuaacau uuucaguaaa aucaucaaga      480

ggaucaucag acccacaagg aguaacaugc ggagcagcaa cacucagcgc agaaagagua      540

agaggagaua auaaagaaua cgaauacuca guggaaugcc aagaagauag ugcaugccca      600

gcagccgaag aaucauuacc aauugaaguc auggucgacg cuguacauaa auuaaaauac      660

gaaaauuaca caaguucauu cuuuauaaga gacauaauaa aaccagaucc accaaaaaau      720

cuacaacuaa aaccauuaaa aaauaguaga caaguagaag uaagcuggga auauccagac      780

acauggucaa caccacacag uuauuucuca uuaacauucu guguacaagu acaaggaaaa      840

aguaaaagag aaaaaaaaga uagaguuuuc acagacaaaa cauccgcaac aguuauaugu      900

agaaaaaacg caucaauauc aguaagagcc caagacagau acuacucauc aaguugguca      960

gaaugggcau cgguaccaug cagcuaa                                          987


<210>  627
<211>  984
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  IL12B(1-328)

<400>  627
augugccacc aacaacuagu uauuuccugg uucucauuag uauuccuagc cucaccauua       60

guagcuauau gggaauuaaa aaaagaugua uacguaguag aacuagacug guacccagau      120

gcaccaggag aaaugguagu acuaaccugc gacacaccag aagaagacgg aauaacaugg      180

acccuagacc aaucaucaga aguauuagga aguggaaaaa cacuaacaau acaaguaaaa      240

gaauucggag acgcaggaca auauacuugc cacaaaggag gagaaguauu aagucauuca      300

uuacuccuau uacacaaaaa agaagacgga auauggagca ccgacauacu aaaagaccaa      360

aaagaaccaa aaaacaaaac auuccuaaga ugcgaagcaa aaaacuacuc aggaagauuu      420

acaugcuggu ggcuaacaac aauaucaaca gaccuaaccu ucuccguuaa aaguucaaga      480

ggaaguucag auccacaagg aguaacaugu ggagcagcaa cacuaagcgc agaaagagua      540

agaggcgaca auaaagaaua ugaauacuca guagaaugcc aagaagauuc agcauguccc      600

gcggccgaag aaucacuacc aauagaagua augguagacg caguacacaa acucaaauau      660

gaaaacuaca caucaucauu cuuuauaaga gacauaauaa aaccagaccc accaaaaaau      720

cuacaacuaa aaccauuaaa aaacucaaga caaguugaag uaagcuggga auauccagac      780

acauggucaa caccacacuc auacuuuuca cuaacauuuu gcguacaagu acaagguaaa      840

ucaaaaagag aaaaaaaaga ucgaguauuu acagacaaaa caagugcaac agucauaugu      900

agaaaaaacg caucaauauc agucagagca caagacagau auuacaguag uucaugguca      960

gaaugggcaa gcguuccaug cuca                                             984


<210>  628
<211>  921
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  IL12B(23-328)

<400>  628
auaugggaac ucaaaaaaga uguauacgua gucgaacuag acugguaccc agacgcacca       60

ggagaaaugg uaguacuaac augugauaca ccagaagaag auggaauaac auggacacua      120

gaccaaucau cagaaguauu aggaucagga aaaacacuaa caauacaagu aaaagaauuu      180

ggagaugcag gacaauauac augccacaaa ggaggagaag uacuaucgca cagcuuauua      240

cuacuacaca aaaaagaaga cggaauaugg agcacagaca uauuaaaaga ccaaaaagaa      300

ccaaaaaaca aaacauucuu acgaugcgaa gcaaaaaacu auucaggaag auucacaugc      360

ugguggcuaa caacaaucag cacagaccua acauuuucag uaaaaucaag cagaggauca      420

ucagauccac aaggagucac auguggagca gcaacacuuu cagccgaaag aguuagagga      480

gauaauaaag aauacgaaua cucaguagaa ugccaagaag acagcgcaug uccagcagca      540

gaagaaagcc uaccaauaga aguaauggua gacgcaguuc acaaauuaaa auacgaaaau      600

uacacaucau cauucuucau aagagacaua auaaaaccag acccaccaaa aaaccuacaa      660

uuaaaaccac uaaaaaacag cagacaagua gaaguaucau gggaauaucc agacacaugg      720

ucaacaccuc acagcuacuu uucacuaaca uucugcguac aaguacaagg aaaaucaaaa      780

agagaaaaaa aagacagagu auucacagac aaaacaagcg caacaguaau augcagaaaa      840

aacgccagca uaucaguuag agcacaagac agauauuaca gcucaagcug gucagaaugg      900

gcaucagucc ccugcucaua a                                                921


<210>  629
<211>  54
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Linker-sFvCC49-218

<400>  629
ggaaguacaa guggaagugg aaaaccagga aguggagaag gaaguacaaa agga             54


<210>  630
<211>  1632
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  IL12

<400>  630
augugccauc aacaacuagu aauauccugg uucuccuuag uguucuuagc aucuccacua       60

guagcaauau gggaauuaaa aaaagacgua uacguaguag aauuagacug guauccugac      120

gcaccaggug aaaugguugu auuaacaugc gauacuccag aagaagacgg aauaacaugg      180

acacucgacc aaucaucaga aguacuaggu ucaggaaaaa cacuaacuau ucaaguaaaa      240

gaauucggag augcaggcca auacacgugu cauaaaggag gcgaaguacu cagccauuca      300

cuauuauuac uucacaaaaa agaagacgga auauggagua cagacauauu aaaagaucaa      360

aaagaaccaa aaaauaaaac auuuuugaga ugcgaagcaa aaaauuauuc aggaagauuu      420

acauguuggu ggcuaaccac cauaucaaca gaucuaacau ucuccguaaa aucaucaaga      480

ggaucaucgg acccucaagg aguaacaugc ggagcagcaa cacuaucagc agaaagagua      540

agaggagaua auaaagaaua cgaauauuca guagaaugcc aagaggacag cgcuugcccc      600

gccgcagaag aaagcuuacc uauagaaguu augguagacg caguacauaa guuaaaauau      660

gagaauuaca caucauccuu uuucauaaga gauauuauaa aaccugaucc acccaagaac      720

cuacaauuaa aaccacuaaa aaauagucga cagguugaag uuucauggga auacccagac      780

acauggagca caccacacuc auacuucuca cuaacauucu guguacaagu acaaggaaaa      840

ucgaaacgcg aaaaaaaaga cagaguauuu acagacaaaa caagugcaac agugauaugu      900

cgaaaaaacg caucaauuuc aguaagagca caagacagau auuacucauc aagcugguca      960

gaaugggcau cuguacccug cagcggaagu acaucaggau cagguaaacc uggaucugga     1020

gaaggaucaa cuaaaggaag aaauuuaccc guggcaacac cagacccagg aauguucccc     1080

ugucuacacc acucgcaaaa ucuacuaaga gcagugucaa acaugcuaca aaaagcaaga     1140

caaacacuag aauuuuaucc auguacuuca gaagaaauag accaugaaga cauuaccaaa     1200

gacaaaacau caacagucga agcauguuua ccauuagaau uaacaaaaaa ugaaucaugu     1260

uuaaauaguc gugaaacuuc auuuauaaca aacggcucau gccuagcauc aagaaaaaca     1320

aguuucauga uggcacuaug ccucucauca auauaugaag aucuaaaaau guaucaggua     1380

gaauuuaaaa cuaugaacgc gaaauuacua auggauccaa aaagacaaau cuuccuagac     1440

caaaacaugu uagcaguaau agacgaacua augcaagcac uaaacuucaa uagcgaaacc     1500

guaccacaaa aaucaucccu agaagaaccu gacuucuaca aaacuaaaau aaaauuaugu     1560

auauuacucc augcauucag aauaagagca guaacaauag acagaguaau guccuaccua     1620

aaugcuucuu aa                                                         1632


<210>  631
<211>  786
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  CD40LG

<400>  631
augauagaaa cauacaauca aacaaguccc agauccgcag caacaggucu accaauauca       60

augaaaauau uuauguauuu acuaacagua uuccuuauaa cacaaaugau aggauccgca      120

cuauucgcag uauaccuaca cagaagauua gacaaaauag aagacgaaag aaaccuacac      180

gaagacuucg uauucaugaa aacaauacaa agaugcaaua caggagaaag aucauuauca      240

cuacuaaacu gcgaagaaau aaaaagccaa uuugaagggu uugucaaaga cauaaugcua      300

aacaaagaag aaaccaaaaa agaaaacuca uucgaaaugc aaaaaggaga ucaaaaccca      360

caaauagcag cacacguaau aucagaagca ucaucaaaaa caacaucagu acuacaaugg      420

gccgaaaaag gauacuacac aaugucaaac aaccuaguaa cacuagaaaa cggaaaacaa      480

uuaacaguaa aaagacaagg acuauacuac aucuaugccc aaguaaccuu cugcuccaac      540

agagaagcau caucacaagc accauucauc gcaucacuau gccuaaaauc accaggaaga      600

uucgaaagaa uauuacuaag agcagcaaac acacacucau cagccaaacc augcggacaa      660

caaucaauac accuaggagg agucuucgaa cuacaaccag gagcaucagu auucguaaac      720

guaacagauc caucacaagu aucacacgga acaggauuca caucauuugg acuacuaaaa      780

cucuaa                                                                 786


<210>  632
<211>  1632
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  IL12(IL12B-Linker-IL12A)

<400>  632
augugccacc agcagcuggu gaucagcugg uucucccucg ucuuccuggc cagcccccug       60

guggccaucu gggagcucaa gaaggacgug uacgucgugg agcuggacug guacccggac      120

gcgcccggcg agaugguggu ccugaccugc gacacccccg aggaggacgg gaucacgugg      180

acccucgacc aguccagcga ggugcugggc uccgggaaga cccugaccau ccaggugaag      240

gaguucggcg acgccgggca guacacgugc cacaagggcg gcgagguccu cagccacucc      300

cugcugcucc ugcacaagaa ggaggacggg aucuggagca ccgacauccu gaaggaccag      360

aaggagccca agaacaagac cuuccuccgc ugcgaggcca agaacuacuc cggccgguuc      420

acgugcuggu ggcugaccac caucagcacc gaccugaccu ucuccgucaa gagcucccgc      480

gggagcuccg acccgcaggg cgugacgugc ggggccgcca cccucagcgc ggagcgggug      540

cgcggcgaca acaaggagua cgaguacucc guggagugcc aggaggacag cgccugcccc      600

gccgccgagg agucccugcc caucgaggug auggucgacg cggugcacaa gcugaaguac      660

gagaacuaca ccagcagcuu cuucauccgg gacaucauca agcccgaccc gcccaagaac      720

cuccagcuga agccccugaa gaacucccgc cagguggagg ucagcuggga guaccccgac      780

accuggucca cgccgcacag cuacuucucc cucaccuucu gcguccaggu gcagggcaag      840

agcaagcggg agaagaagga ccgcguguuc accgacaaga ccuccgccac ggugaucugc      900

cggaagaacg ccagcaucuc cgugcgcgcc caggaccggu acuacagcuc cagcuggucc      960

gagugggcca gcguccccug cuccggcagc accuccggga gcggcaagcc cggguccggc     1020

gaggggagca ccaagggccg gaaccugccg guggccaccc ccgaccccgg cauguucccc     1080

ugccugcacc acagccagaa ccuccugcgc gccgugucca acaugcugca gaaggcccgg     1140

cagacgcucg aguucuaccc gugcaccagc gaggagaucg accacgagga caucaccaag     1200

gacaagaccu ccacggucga ggccugccug ccccuggagc ucaccaagaa cgagagcugc     1260

cugaacuccc gcgagaccag cuucaucacc aacggguccu gccuggcgag ccggaagacg     1320

uccuucauga uggcccucug ccugagcucc aucuacgagg accugaagau guaccaggug     1380

gaguucaaga ccaugaacgc caagcuccug auggacccca agcgccagau cuuccuggac     1440

cagaacaugc ucgccgugau cgacgagcug augcaggcgc ugaacuucaa cagcgagacc     1500

gucccccaga aguccagccu cgaggagccg gacuucuaca agaccaagau caagcugugc     1560

auccugcucc acgccuuccg gauccgcgcc gugacgaucg accgggugau guccuaccug     1620

aacgccagcu ga                                                         1632


<210>  633
<211>  1632
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  IL12(IL12B-Linker-IL12A)

<400>  633
augugccacc agcagcucgu caucuccugg uucucccucg ucuuccucgc cuccccccuc       60

gucgccaucu gggagcucaa gaaggacguc uacgucgucg agcucgacug guaccccgac      120

gcccccggcg agauggucgu ccucaccugu gacacccccg aggaggacgg caucaccugg      180

acccucgacc aguccuccga gguccucggc uccggcaaga cccucaccau ccaggucaag      240

gaguucggcg acgccggcca guacaccugu cacaagggcg gcgagguccu cucccacucc      300

cuccuccucc uccacaagaa ggaggacggc aucuggucca ccgacauccu caaggaccag      360

aaggagccca agaacaagac cuuccuccgc ugcgaggcca agaacuacuc cggccgcuuc      420

accuguuggu ggcucaccac caucuccacc gaccucaccu ucuccgucaa guccucccgc      480

ggcuccuccg acccccaggg cgucaccugu ggcgccgcca cccucuccgc cgagcgcguc      540

cgcggcgaca acaaggagua cgaguacucc gucgagugcc aggaggacuc cgccugcccc      600

gccgccgagg agucccuccc caucgagguc auggucgacg ccguccacaa gcucaaguac      660

gagaacuaca ccuccuccuu cuucauccgc gacaucauca agcccgaccc ccccaagaac      720

cuccagcuca agccccucaa gaacucccgc caggucgagg ucuccuggga guaccccgac      780

accuggucca ccccccacuc cuacuucucc cucaccuucu gcguccaggu ccagggcaag      840

uccaagcgcg agaagaagga ccgcgucuuc accgacaaga ccuccgccac cgucaucugc      900

cgcaagaacg ccuccaucuc cguccgcgcc caggaccgcu acuacuccuc cuccuggucc      960

gagugggccu ccguccccug cuccggcucc accuccggcu ccggcaagcc cggcuccggc     1020

gagggcucca ccaagggccg caaccucccc gucgccaccc ccgaccccgg cauguucccc     1080

ugccuccacc acucccagaa ccuccuccgc gccgucucca acaugcucca gaaggcccgc     1140

cagacccucg aguucuaccc cugcaccucc gaggagaucg accacgagga caucaccaag     1200

gacaagaccu ccaccgucga ggccugccuc ccccucgagc ucaccaagaa cgaguccugc     1260

cucaacuccc gcgagaccuc cuucaucacc aacggcuccu gccucgccuc ccgcaagacc     1320

uccuucauga uggcccucug ccucuccucc aucuacgagg accucaagau guaccagguc     1380

gaguucaaga ccaugaacgc caagcuccuc auggacccca agcgccagau cuuccucgac     1440

cagaacaugc ucgccgucau cgacgagcuc augcaggccc ucaacuucaa cuccgagacc     1500

gucccccaga aguccucccu cgaggagccc gacuucuaca agaccaagau caagcucugc     1560

auccuccucc acgccuuccg cauccgcgcc gucaccaucg accgcgucau guccuaccuc     1620

aacgccuccu ga                                                         1632


<210>  634
<211>  1632
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  IL12(IL12B-Linker-IL12A)

<400>  634
augugccacc agcaacuggu gaucagcugg uucucccucg ucuuucuugc cucuccccug       60

guugcuauuu gggaguugaa gaaagacgug uacguagugg aauuagauug guauccugac      120

gcaccaggcg agauggucgu gcugaccugu gauacaccgg aagaggacgg gauaacuugg      180

acgcuagauc agucaaguga aguucucgga agcgguaaga cccugacaau ccaggugaaa      240

gaguucggcg acgccgggca guacacuugc cauaagggag gcgagguccu uucccacucu      300

cuguugcucc ugcauaaaaa ggaagauggu auuuggucga ccgacauccu gaaggaucaa      360

aaagagccca agaacaaaac auuucucaga ugugaagcga agaauuauuc agggagguuu      420

accugcuggu gguuaacuac aauuagcacc gaccugacgu ucagugugaa auccucucgg      480

ggaagcuccg auccucaggg cguaacuugu ggcgcugcca cccuuucagc agagcgcguu      540

cgaggggaca acaaggagua cgaauauagu guggagugcc aggaagauag cgccugucca      600

gcugcagagg aaucuuugcc caucgagguc augguggacg ccgugcacaa gcugaaauac      660

gagaauuaua cauccucauu cuuuauacgu gacaucauua agccugaucc acccaaaaac      720

cuacagcuca agccucugaa aaauagcaga caagucgaag uuaguuggga guacccagac      780

acuuggucua ccccgcauuc cuacuucagc cuuacauuuu gcgugcaggu acagggaaag      840

ucgaaaaggg aaaagaagga ucggguguuc accgacaaaa cgucugcuac ugucaucugu      900

cgcaagaacg ccuccauuuc agugagagcg caggauaggu auuacaguag cuccuggucu      960

gagugggcaa gcguucccug cucaggcagc accuccgggu cuggaaagcc cgguucaggc     1020

gaggggagua caaaaggaag gaaccucccu guugccacac cagauccggg cauguucccc     1080

ugucugcauc acucucagaa ucuucugcgg gcggugucaa acauguugca aaaggcucgc     1140

cagacucucg aguuuuaccc uugcacgagu gaagagaucg accaugaaga uauuaccaaa     1200

gacaagacaa gcacuguaga ggccugucug ccacuggaac ucaccaaaaa ugaguccugc     1260

uuaaacucuc gagagacauc guucauaacc aaugggucau gucuggcaag ccguaagaca     1320

aguuuuauga uggcccuuug cuuguccucu aucuaugaag aucugaaaau guaccaggug     1380

gaguucaaga cuaugaacgc uaagcuacuc auggacccca aaagacagau uuuucuggau     1440

caaaauaugc uugcagucau cgacgaacug augcaggccu ugaacuucaa uagcgagacc     1500

gugccucaga aguccucacu cgaggaacca gauuuuuaua aaacgaagau uaaacugugu     1560

aucuuacugc acgcuuucag gauacgggcc guuacuaucg accgcgugau gaguuaccuc     1620

aacgcgagcu ga                                                         1632


<210>  635
<211>  1632
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  IL12(IL12B-Linker-IL12A)

<400>  635
augugccacc agcagcuggu gaucagcugg uucagccugg uguuccuggc cagcccccug       60

guggccaucu gggagcugaa gaaggacgug uacguggugg agcuggacug guaccccgac      120

gcccccggcg agaugguggu gcugaccugc gacacccccg aggaggacgg caucaccugg      180

acccuggacc agagcagcga ggugcugggc agcggcaaga cccugaccau ccaggugaag      240

gaguucggcg acgccggcca guacaccugu cacaagggcg gcgaggugcu gagccacagc      300

cugcugcugc ugcacaagaa ggaggacggc aucuggagca ccgacauccu gaaggaccag      360

aaggagccca agaacaagac cuuccugaga ugcgaggcca agaacuacag cggcagauuc      420

accuguuggu ggcugaccac caucagcacc gaccugaccu ucagcgugaa gaguagcaga      480

ggcagcagcg acccccaggg cgugaccugc ggcgccgcca cccugagcgc cgagagagug      540

agaggcgaca acaaggagua cgaguacagc guggagugcc aggaggacag cgccugcccc      600

gccgccgagg agagccugcc caucgaggug augguggacg ccgugcacaa gcugaaguac      660

gagaacuaca ccagcagcuu cuucaucaga gacaucauca agcccgaccc ccccaagaac      720

cugcagcuga agccccugaa gaacagcaga cagguggagg ugagcuggga guaccccgac      780

accuggagca ccccccacag cuacuucagc cugaccuucu gcgugcaggu ucagggcaag      840

agcaagagag agaagaagga cagaguguuc accgacaaga ccagcgccac cgugaucugc      900

agaaagaacg ccagcaucag cgugagagcc caggacagau acuacagcag cagcuggagc      960

gagugggcca gcgugcccug cagcggcagc accagcggca gcggcaagcc cggcagcggc     1020

gagggcagca ccaagggcag aaaccugccc guggccaccc ccgaccccgg cauguucccc     1080

ugccugcacc acagccagaa ccugcugaga gccgugagca acaugcugca gaaggccaga     1140

cagacccugg aguucuaccc cugcaccagc gaggagaucg accacgagga caucaccaag     1200

gacaagacca gcaccgugga ggccugccug ccccuggagc ugaccaagaa cgagagcugc     1260

cugaacagca gagagaccag cuucaucacc aacggcagcu gccuggccag cagaaagacc     1320

agcuucauga uggcccugug ccugagcagc aucuacgagg accugaagau guaccaggug     1380

gaguucaaga ccaugaacgc caagcugcug auggacccca agagacagau cuuccuggac     1440

cagaacaugc uggccgugau cgacgagcug augcaggccc ugaacuucaa cagcgagacc     1500

gugccccaga agaguagccu ggaggagccc gacuucuaca agaccaagau caagcugugc     1560

auccugcugc acgccuucag aaucagagcc gugaccaucg acagagugau gagcuaccug     1620

aacgccagcu ga                                                         1632


<210>  636
<211>  1632
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  IL12(IL12B-Linker-IL12A)

<400>  636
augugccacc agcaacuggu gaucagcugg uucucccucg ucuuucuggc cucuccccuu       60

guugcuauuu gggagcugaa gaaagacgug uacguggucg aacucgauug guauccugac      120

gccccgggcg agaugguggu ucugaccugu gauacacccg aagaggacgg gaucacgugg      180

acccuugauc agagcuccga agugcuggga ucuggcaaga cacucaccau ucaggucaaa      240

gaguucgggg acgcgggaca guacacaugc cauaagggcg gggaggugcu gagccacucc      300

cugcuccugc uucauaaaaa ggaagaugga aucuggucua ccgacauucu gaaggaucaa      360

aaagagccua agaacaaaac auuucucaga ugugaagcua agaauuauag cggccgguuu      420

accugcuggu ggcugacgac caucuccaca gaccuuaccu ucagcguuaa aucuucccgc      480

ggcagcucug auccccaggg ggugacaugu ggagccgcca cccuguccgc ugagagaguc      540

cggggcgaca acaaggagua cgaauauagc guggagugcc aggaagauuc ugccuguccu      600

gcugccgagg aaucccuccc caucgaggug auggucgacg cgguucacaa gcugaaauac      660

gagaauuaua cgagcuccuu cuuuauucgc gacaucauua agccugaucc gcccaaaaac      720

cugcagcuca agccucugaa aaauucuaga caaguggaag ugagcuggga guaccccgac      780

acauggucca ccccucauag cuacuucucu cuuacauuuu gcguccaggu gcaggggaag      840

uccaaacggg aaaagaagga ucgcguuuuc accgacaaaa ccagcgccac agugaucugu      900

agaaagaacg cuucuauuag cguccgggcc caggaucgcu auuacuccuc uagcuggucc      960

gagugggcua gcgugcccug cucuggcagc accuccgggu cuggaaagcc cggcagcggg     1020

gagggaucca caaaaggccg gaaccugccu guugcgacac cggaucccgg cauguucccu     1080

ugucuccauc acucucagaa ucugcugcgc gcugugagca acaugcucca aaaggccaga     1140

cagacgcugg aguuuuaccc cugcaccucc gaagagaucg accaugaaga uauuacaaaa     1200

gacaagaccu cuacagugga ggccugucuu ccucuggaac ucaccaaaaa ugagagcugc     1260

cugaacuccc gggagacauc uuucaucacc aaugggagcu gucuugcuuc ccgcaagacg     1320

agcuuuauga uggcccugug ccucucuucc auuuaugaag aucugaaaau guaccagguc     1380

gaguucaaga ccaugaacgc uaagcugcuc auggacccca aaagacagau cuuucuggau     1440

caaaauaugc uugccgugau ugacgaacug augcaggcgc ucaacuucaa uagcgagaca     1500

guuccucaga agucuucccu ggaggaaccg gauuuuuaua aaaccaagau caaacuuugu     1560

auccugcucc acgccuuccg gauucgcgcu gugacaaucg acagagucau gagcuaccug     1620

aacgccucuu ga                                                         1632


<210>  637
<211>  1632
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  IL12(IL12B-Linker-IL12A)

<400>  637
augugccacc aacaacuggu aauaucaugg uucucacugg uauucuuggc aucaccccua       60

guagcaauau gggaacuaaa aaaagacgua uacguaguag aacuagacug guacccagac      120

gcaccaggag aaaugguagu auuaacaugc gacacaccag aagaagaugg aauaacuugg      180

acauuagacc aaucaaguga aguauuagga ucaggcaaaa cacuaacuau acaaguaaaa      240

gaauuuggag acgcaggaca auacacgugc cacaaaggag gcgaaguccu aucacauuca      300

cuacuauuau uacacaaaaa agaagacgga aucuggagca cagacauauu aaaagaccaa      360

aaagaaccaa aaaacaaaac auuucuaaga ugcgaagcua aaaacuauuc aggaagauuc      420

acaugcuggu ggcuaacaac caucaguacc gacuuaacau ucucaguaaa aucaucaaga      480

ggaucaucag acccacaagg aguaacaugu ggagcagcaa cacuaagcgc agaaagagua      540

cgaggagaca acaaagaaua cgaauauuca guagaauguc aagaagacuc agcaugcccu      600

gcagcagaag aaucauuacc aauagaagua auggucgacg cuguacacaa acuaaaauau      660

gaaaauuaca caagcaguuu cuucauaaga gacauaauaa aacccgaccc accaaaaaac      720

cuacaacuaa aaccauuaaa aaauucaaga caaguagaag uaucauggga auacccagau      780

acauggagca caccacacag uuacuucuca uuaacauucu gcguacaagu acaaggaaaa      840

aguaaaagag aaaaaaaaga cagaguauuc acagauaaga cuucagcaac aguaauaugc      900

agaaaaaacg caagcauaag cguacgagca caagacagau auuacucaag cucaugguca      960

gaaugggcau caguaccaug uucaggaagu acaaguggaa guggaaaacc aggaagugga     1020

gaaggaagua caaaaggaag aaaccuccca guagccacac cagacccagg aauguucccc     1080

ugccuccacc auucccaaaa ccuacuaaga gcaguaucaa acaugcuaca aaaagcaaga     1140

caaacacuag aguucuaucc augcacauca gaagaaauag accacgaaga cauaacaaaa     1200

gacaaaacau caaccguaga agcaugccuc ccacucgaac ucacaaaaaa cgaaucaugc     1260

cuaaacucaa gagaaacauc auucauaaca aacggcucau gcuuagccuc aagaaaaaca     1320

ucauucauga uggcacuaug ccucucaucc auauaugaag acuuaaaaau guaccaagua     1380

gaauuuaaaa ccaugaacgc aaaauuacua auggacccaa aaagacaaau auuccuagac     1440

caaaacaugc uagcaguaau agacgaacua augcaagcac uaaacuucaa cucagaaacc     1500

guaccccaaa aaucaucucu agaagaacca gacuucuaca aaacaaaaau aaaacuaugc     1560

auacuacuac acgccuucag aauaagagcc gucacaauag acagagucau gucauaccua     1620

aacgccucau aa                                                         1632


<210>  638
<211>  1632
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  IL12(IL12B-Linker-IL12A)

<400>  638
augugccacc agcaacuggu gaucagcugg uucucccucg ucuuucuggc cagucccuug       60

guggcaauuu gggagcugaa gaaagacgua uacguggucg aacucgauug guauccagac      120

gccccgggcg agaugguggu gcugaccugu gauacucccg aagaggacgg gaucaccugg      180

acguuggauc agagcuccga aguccugggu aguggcaaga cucucaccau ucaggugaaa      240

gaguucgggg acgcgggcca guauaccugc cauaagggug gggagguacu gagccacucc      300

cugcuccugu ugcauaaaaa ggaagauggc aucuggagca cugacauucu gaaggaucaa      360

aaagagccaa agaacaaaac cuuucucagg ugugaagcca agaauuacuc cggccgguuc      420

acgugcuggu ggcugacuac caucaguacu gaccugaccu uuagcgugaa auccagccgc      480

gggaguuccg auccccaggg ugucaccugu ggcgcagcca cguugagcgc agagagggug      540

cgcggggaca acaaggagua cgaauauucc guggagugcc aggaagauag ugccugucca      600

gcggccgagg aaagccuccc caucgagguc augguggacg caguacacaa acugaaguac      660

gagaauuaua cuuccagcuu cuuuauucgg gacaucauua agccagaucc gcccaaaaac      720

cugcagcuca agccacugaa aaauaguagg caaguggaag ucuccuggga guaccccgac      780

accuggagca cuccacauag uuacuucucc uugaccuuuu gcguccaggu gcagggcaag      840

agcaaacggg aaaagaagga ucgcguguuc accgacaaaa cuagcgccac ggugaucugu      900

aggaagaacg ccuccauuag uguacgggca caggaucgcu auuacagcuc cagcuggagu      960

gagugggccu ccgugcccug cagcggcagc accuccggga gugguaagcc cggcagcggg     1020

gagggcucca cuaaaggucg gaaccugcca guggcgacuc cggaucccgg cauguuccca     1080

ugucuccauc acagucagaa ucugcugcgc gccguaagca acaugcucca aaaggcaagg     1140

cagacccugg aguuuuaccc cugcacgucc gaagagaucg accaugaaga uauuacuaaa     1200

gacaagacca guaccgugga ggccuguuug ccacuggaac ucacuaaaaa ugagagcugc     1260

cugaacuccc gggagaccag cuucaucacg aauggguccu gucuggcaag ucgcaagacu     1320

agcuuuauga uggccuugug ccucuccagc auuuaugaag aucugaaaau guaccagguc     1380

gaguucaaga ccaugaacgc gaagcugcuc auggacccca aaaggcagau cuuucuggau     1440

caaaauaugu uggccgugau ugacgaacug augcaggcac ucaacuucaa uagugagacu     1500

gugccacaga aguccagccu ggaggaaccg gauuuuuaua aaaccaagau caaacugugu     1560

aucuugcucc acgccuuccg gauucgcgcc gucaccaucg acagggugau guccuaccug     1620

aacgcaaguu ga                                                         1632


<210>  639
<211>  1632
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  IL12(IL12B-Linker-IL12A)

<400>  639
augugccacc aacaacucgu cauaagcugg uucagccuag uauuccucgc cucaccccuc       60

gucgccaucu gggaacucaa gaaagacgua uacgucgucg aacuagacug guaccccgac      120

gcacccggag aaaugguagu acucacaugc gacacccccg aagaagacgg caucacaugg      180

accuuagacc aaucaucaga aguccucgga uccggaaaaa cccucacaau ccaagucaaa      240

gaguucggcg acgccggcca auacacaugc cacaaaggcg gagaaguccu cucacacuca      300

cuccuucuac uacacaagaa agaagacggc aucuggucca ccgacauacu caaagaccaa      360

aaagaaccca aaaacaaaac cuuccuccgc ugcgaagcca aaaacuacuc cggccgauuc      420

acaugcuggu ggcucaccac caucuccacc gaccugaccu ucuccgucaa auccagcagg      480

ggcuccucag acccacaagg cguaaccugc ggcgcagcca cccuaucggc cgaacgaguc      540

cgcggagaca acaaagaaua cgaauacagc gucgaaugcc aagaagacuc agcaugccca      600

gcagccgaag aaucacuccc caucgaaguc auggucgacg ccguccacaa acuaaaauac      660

gaaaacuaca caagcucauu cuucauccgc gacauaauca aacccgaccc accgaaaaac      720

cuccaacuca aaccccuuaa aaacagccgc caagucgaag ucuccuggga auaccccgac      780

accuggucca caccccacuc cuacuucuca cucaccuucu gcguccaagu ccaaggcaaa      840

uccaaacgcg aaaagaaaga ccgcguauuc accgacaaaa ccuccgccac agucaucugc      900

cgcaaaaacg ccucaaucuc cguccgcgcc caagaccgau acuacagcuc cuccugguca      960

gaaugggccu ccgucccaug cuccgggagc acgagcggga gcgggaagcc gggaagugga     1020

gagggaagua caaagggacg caaucucccc gucgccaccc ccgaccccgg aauguuuccc     1080

ugccuccacc acucacaaaa ccuccuacgc gccgucucaa acaugcuuca aaaagcccga     1140

caaacccucg aauuuuaccc cugcaccucc gaagaaaucg accacgaaga cauaaccaaa     1200

gacaaaaccu ccaccgucga agccugccua ccauuagaac uaaccaaaaa cgaauccugc     1260

cucaacucac gcgaaaccuc cuucaucaca aacggcucau gccucgccuc acgcaaaacc     1320

uccuucauga uggcccucug ccuaucauca aucuaugaag accucaaaau guaccaagua     1380

gaauuuaaaa ccaugaacgc caaacuccuc auggacccca aacgccaaau cuuccucgac     1440

caaaacaugc ucgcagucau cgacgaacuc augcaagccc ucaacuucaa cucagaaaca     1500

gucccacaaa aauccucccu cgaagaaccc gacuucuaua aaaccaaaau caaacucugc     1560

auccuccucc acgccuuccg cauacgcgcc guaaccaucg accgcguaau gucauaccua     1620

aaugccucuu aa                                                         1632


<210>  640
<211>  1632
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  IL12(IL12B-Linker-IL12A)

<400>  640
augugucacc aacaacuugu aaucagcugg uucucccucg ucuuccucgc cucaccccuc       60

gucgccaucu gggaacucaa aaaagacguc uacguagucg aacucgacug guaccccgac      120

gccccaggag aaauggucgu acucaccugu gacacccccg aagaagacgg caucaccugg      180

acccucgacc aauccuccga aguccucggu ucaggaaaaa cccucaccau ccaaguaaaa      240

gaauuuggcg acgccgggca auauaccugc cacaaaggcg gcgagguccu aucccacuca      300

cuccuccucc uccacaagaa agaagacgga aucuggucca ccgacauccu uaaagaccaa      360

aaagaaccaa aaaacaaaac auuccuccgc ugcgaagcca aaaacuacag cggccgcuuc      420

accuguuggu ggcuaaccac aauaucaacc gacuuaaccu ucagcgucaa auccuccaga      480

ggauccagcg acccacaagg aguuaccugc ggagccgcaa cacucagcgc cgaacgaguc      540

cgcggagaca acaaagaaua cgaauacucc gucgaaugcc aagaagacuc agcaugcccc      600

gccgcagaag aaucccuacc caucgaagua augguagacg ccguccacaa acucaaauac      660

gaaaacuaca ccagcuccuu cuucauccga gacaucauca aacccgaccc cccaaaaaac      720

cuccaacuaa aaccccucaa aaacagccgc caaguagaag uauccuggga auaccccgac      780

accuggucca caccccacuc cuacuucucg cucacguucu gcguccaagu ccaaggcaaa      840

uccaaacgag aaaaaaaaga ccgcgucuuc accgacaaaa cuuccgccac cgucaucugc      900

cgcaaaaacg ccagcaucag cguccgcgca caagaccgcu acuacucaag cuccuggucc      960

gaaugggccu ccgucccaug cucagggagu acgaguggga gugggaagcc ggggaguggg     1020

gaggggagua cgaaggggcg uaaccuccca gucgccaccc cagaccccgg aauguucccc     1080

ugccuccauc acucccaaaa ucuccuccgu gccgucucca acaugcucca aaaagcccgc     1140

caaacccucg aauuuuaucc augcaccucc gaagaaauag accaugaaga caucaccaaa     1200

gacaaaacau ccaccgucga agccugccuc ccccucgaac ucacaaaaaa cgaaucaugc     1260

cucaacuccc gcgaaaccuc cuucauaacc aacggcucau gccucgccuc ucgcaaaacc     1320

ucauucauga uggcccucug ccuauccucu aucuacgaag accucaaaau guaccaaguc     1380

gaauuuaaaa ccaugaacgc caaacuccuc auggacccca aacgccaaau cuuccucgac     1440

caaaacaugc ucgcagucau cgacgaacuc augcaagcac ucaacuucaa cucagaaacc     1500

gucccccaaa aauccucccu cgaagaaccc gacuucuaca aaacaaaaau aaaacucugc     1560

auccuccucc acgccuuccg cauccgagca gucaccaucg aucgcgucau guccuaccua     1620

aacgccuccu aa                                                         1632


<210>  641
<211>  1632
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  IL12(IL12B-Linker-IL12A)

<400>  641
augugccacc aacaacucgu caucuccugg uucucccucg ucuuccuagc cuccccacuc       60

gucgccaucu gggaacucaa aaaagacgua uacgucgucg aacucgacug guaccccgac      120

gccccaggag aaauggucgu ccuaaccugc gacacacccg aagaagacgg uaucaccugg      180

acccucgacc aauccuccga aguccuaggc uccggcaaga cccucaccau ccaagucaaa      240

gaauuuggcg acgcaggaca auacaccugu cacaaaggcg gcgaaguccu cagccacagc      300

cuucuccuac uccauaaaaa agaagacggc aucuggucca cugacauccu caaagaccaa      360

aaagaaccca aaaauaaaac cuuccuccgc ugcgaagcca aaaacuacuc cggccgauuc      420

accuguuggu ggcuaaccac aaucagcacc gaccucaccu ucucagucaa auccucccgc      480

ggcucaucug acccccaagg cgucacaugc ggcgccgcca cccucuccgc cgaacgcguc      540

cgcggcgaca acaaagaaua cgaauacucc gucgaauguc aagaagacuc cgccugcccc      600

gccgccgaag aaucacuccc caucgaaguc auggucgacg caguccacaa acucaaauac      660

gaaaacuaca ccuccuccuu cuucauccgc gacauaauaa aacccgaccc acccaaaaac      720

cuccaacuca agccacucaa aaacucccga caagucgaag ucuccuggga guaccccgac      780

accuggucca caccacacuc cuacuucucc cucaccuucu gcguccaagu ccaaggcaaa      840

uccaaacgcg aaaaaaaaga ccgcguuuuc acagacaaaa ccuccgccac aguaauaugc      900

cgcaaaaacg ccuccaucuc cguccgggcc caagaccgcu acuacuccuc cuccuggucc      960

gagugggccu caguccccug cagcgggagu acgaguggga gugggaagcc ggggaguggg     1020

gaggggagua cgaaggggcg caaccuccca gucgccaccc ccgaccccgg cauguucccc     1080

ugccuccacc acucccaaaa ccuccuccgc gccgucucca acaugcucca aaaagcccgc     1140

caaacccucg aauuuuaccc cugcaccucc gaagagaucg accacgaaga caucaccaaa     1200

gacaaaaccu ccacagucga agccugccuc ccccucgaac ucaccaaaaa cgaauccugc     1260

cuuaacuccc gcgaaaccuc cuucaucacc aacggcuccu gccucgccuc ccgcaaaacc     1320

uccuucauga uggcccucug ccucuccucc aucuacgaag accucaaaau guaccaaguc     1380

gaauuuaaaa ccaugaacgc caaacuccuc auggacccca aacgccaaau cuuccucgac     1440

caaaacaugc ucgccgucau cgacgaacuc augcaagccc ucaacuucaa cuccgaaacc     1500

gucccccaaa aauccucccu cgaagaaccc gacuucuaca aaaccaaaau caaacuuugc     1560

auccuccucc acgcauuccg cauccgcgcc gucaccaucg accgugucau gagcuaccua     1620

aacgccuccu ga                                                         1632


<210>  642
<211>  1632
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  IL12(IL12B-Linker-IL12A)

<400>  642
augugccacc aacaacucgu caucagcugg uucagccucg ucuuccucgc cuccccccua       60

guagccauau gggaacuaaa aaaagacgua uacguuguag aacuagacug guaccccgac      120

gcacccggcg aaauggucgu ccucaccugc gacacccccg aagaagaugg cauaacaugg      180

acccucgacc aauccucaga aguccucggc uccggcaaaa cccucacaau ccaagucaaa      240

gaauucggcg acgccggcca auacaccugc cacaaaggcg gcgaaguccu cucucacucu      300

cuccuccucc uccacaaaaa agaagacggc aucuggucca ccgacauacu caaagaccaa      360

aaagaaccca aaaacaaaac cuuccugcga ugcgaagcca aaaacuacuc cggccgauuc      420

acaugcuggu ggcucaccac caucucaacc gaccucaccu ucuccgucaa auccucccgu      480

ggcagcuccg acccccaagg agucaccugc ggcgcagcca cccucuccgc cgaacgcguc      540

agaggcgaca acaaagaaua cgaauacucc gucgaaugcc aagaggacuc cgccugcccc      600

gccgccgaag aaucacuccc caucgaaguc augguagacg ccguacacaa acuaaaauac      660

gaaaacuaca ccucuucauu cuucauccga gacaucauca aacccgaccc ccccaaaaac      720

cuccaacuca aaccccucaa aaacucccga caagucgaag ucagcuggga auacccagac      780

accuggucca ccccacacuc cuacuucuca cuaaccuucu gcguccaagu ccaaggcaaa      840

ucgaaacgcg aaaaaaaaga cagagucuuc accgacaaaa ccucagccac cgucaucugc      900

cgaaaaaacg caucaaucag cguccgcgcc caagaccgcu acuacuccuc cagcuggagc      960

gaaugggcau ccguccccug cuccgggagu acgaguggga gugggaagcc ggggaguggg     1020

gaggggagua cgaaggggcg caaccucccc gucgccaccc ccgaccccgg cauguucccc     1080

ugccuccacc acucccaaaa ucuccuccgc gccgucucca acaugcucca aaaagcccgc     1140

caaacccucg aauucuaccc cugcacgucc gaagaaaucg accacgaaga caucaccaaa     1200

gacaaaaccu ccaccgucga agccugccuc ccccucgaac ucaccaaaaa cgaauccugc     1260

cucaacucac gcgaaaccuc cuucaucacc aacggcucau gccucgccuc acgaaaaacc     1320

uccuucauga uggcccucug ccucuccuca aucuacgaag accucaaaau guaccaaguc     1380

gaauucaaaa ccaugaacgc caaacuccuc auggacccca aacgccaaau cuuccucgac     1440

caaaacaugc ucgcagucau cgacgaacuc augcaagccc ucaacuucaa cuccgaaacc     1500

gucccccaaa aaucaucccu cgaagaacca gacuucuaca aaaccaaaau caaacucugc     1560

auccuccucc acgccuuccg cauccgcgcc guaaccaucg accgcgucau gucauaccuc     1620

aacgccuccu aa                                                         1632


<210>  643
<211>  1632
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  IL12(IL12B-Linker-IL12A)

<400>  643
augugccauc aacaacuagu aauaucaugg uucucacuag uauucuuagc aaguccccua       60

guagcaauau gggaacuaaa aaaagacguc uacguuguag aauuagacug guacccagac      120

gcaccaggcg aaaugguagu acuaacaugc gauacaccag aagaagacgg aauaacaugg      180

acacuagacc aaucaucaga aguucuagga ucaggaaaaa cauuaacaau acaaguaaaa      240

gaauucgggg acgcaggaca auauacaugc cacaaaggag gagaaguuuu aucacacuca      300

cuacuauuau uacacaaaaa agaagacgga auauggucaa cugacauacu aaaagaucaa      360

aaagaaccaa aaaacaaaac auucuuaaga ugugaagcaa aaaauuacag uggaagauuc      420

acaugcuggu ggcuaacaac aauaaguaca gaccuaacau uuucaguaaa aucaaguaga      480

ggaucaucag acccacaagg cguaacaugu ggagcagcaa cacuaucagc agaacgaguc      540

agaggagaca acaaagaaua cgaauacucc guagaaugcc aagaagacag ugcaugcccc      600

gcagccgaag aaucauuacc aauagaagua augguagacg caguacacaa acuaaaauac      660

gaaaacuaca caagcucauu cuuuauacga gauauaauaa aaccagaccc accaaaaaac      720

cuacaacuaa aaccacuaaa aaacucacgc caaguagaag uauccuggga auacccagau      780

acauggucaa caccacacuc auauuucagc uuaacauucu guguacaagu acaaggaaaa      840

ucaaaaagag aaaaaaaaga uagaguauuc accgacaaga caagcgcaac aguaauuugu      900

agaaaaaacg caucaauauc aguaagagca caagacagau acuacagcuc aagcugguca      960

gaaugggcaa guguaccaug uucaggaagu acaaguggaa guggaaaacc aggaagugga     1020

gaaggaagua caaaaggaag aaaccuacca guagcaacac ccgacccagg aauguuccca     1080

ugccuacacc acucacaaaa ccuacuacgc gcaguaucaa acauguuaca aaaagcacga     1140

caaacacuug aauucuaccc cugcacauca gaagaaauag accacgaaga cauaacaaaa     1200

gacaaaacau ccaccguaga agcaugccuc ccacuagaac uaacaaaaaa cgaaucaugc     1260

cuaaacucaa gagaaacauc auucauaaca aacggaucau gccuagcauc acgaaaaaca     1320

ucauucauga uggcacuaug ccuauccucc auauacgaag accuaaaaau guaccaagua     1380

gaauucaaaa caaugaacgc aaaacuacua auggacccaa aaagacaaau auuccuagac     1440

caaaacaugc ucgcaguaau agacgaacua augcaagcac uaaacuuuaa cucagaaaca     1500

guaccccaaa aaucaucacu agaagaacca gacuucuaca aaacaaaaau aaaauuaugc     1560

auacuccuac acgcauucag aaucagagca guaacaauag accgcguaau gucauaccua     1620

aacgcaucau aa                                                         1632


<210>  644
<211>  1632
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  IL12(IL12B-Linker-IL12A)

<400>  644
augugccacc aacaacuagu uauuuccugg uucucauuag uauuccuagc cucaccauua       60

guagcuauau gggaauuaaa aaaagaugua uacguaguag aacuagacug guacccagau      120

gcaccaggag aaaugguagu acuaaccugc gacacaccag aagaagacgg aauaacaugg      180

acccuagacc aaucaucaga aguauuagga aguggaaaaa cacuaacaau acaaguaaaa      240

gaauucggag acgcaggaca auauacuugc cacaaaggag gagaaguauu aagucauuca      300

uuacuccuau uacacaaaaa agaagacgga auauggagca ccgacauacu aaaagaccaa      360

aaagaaccaa aaaacaaaac auuccuaaga ugcgaagcaa aaaacuacuc aggaagauuu      420

acaugcuggu ggcuaacaac aauaucaaca gaccuaaccu ucuccguuaa aaguucaaga      480

ggaaguucag auccacaagg aguaacaugu ggagcagcaa cacuaagcgc agaaagagua      540

agaggcgaca auaaagaaua ugaauacuca guagaaugcc aagaagauuc agcauguccc      600

gcggccgaag aaucacuacc aauagaagua augguagacg caguacacaa acucaaauau      660

gaaaacuaca caucaucauu cuuuauaaga gacauaauaa aaccagaccc accaaaaaau      720

cuacaacuaa aaccauuaaa aaacucaaga caaguugaag uaagcuggga auauccagac      780

acauggucaa caccacacuc auacuuuuca cuaacauuuu gcguacaagu acaagguaaa      840

ucaaaaagag aaaaaaaaga ucgaguauuu acagacaaaa caagugcaac agucauaugu      900

agaaaaaacg caucaauauc agucagagca caagacagau auuacaguag uucaugguca      960

gaaugggcaa gcguuccaug cucaggaagu acaaguggaa guggaaaacc aggaagugga     1020

gaaggaagua caaaaggaag aaaccuacca guagcaacac cagaccccgg aauguuccca     1080

ugccuccacc acucacaaaa ccuacuaaga gcaguaucaa acauguuaca aaaagccaga     1140

caaacauuag aauuuuaccc auguacauca gaagaaauag accacgaaga cauaacaaaa     1200

gacaaaacau caacaguaga agcaugccua ccauuagaac uaaccaaaaa cgaaucaugc     1260

cuaaacucaa gagaaacauc auucauaaca aacggaucau gccuagcauc aagaaaaaca     1320

ucauucauga uggcacuaug ccuaucaucc auauacgaag accuaaaaau guaccaagua     1380

gaauuuaaaa caaugaacgc aaaacuccua auggacccaa aaagacaaau auuccuagac     1440

caaaauaugc ucgcaguaau agacgaauua augcaagcac uaaacuucaa cucagaaaca     1500

guaccacaaa aaucaucccu agaagaaccc gacuucuaca aaacaaaaau aaaacuaugc     1560

auacuacuac acgcauucag aauaagagcc guaacaauag acagaguaau gucauaccua     1620

aacgcaucau aa                                                         1632


<210>  645
<211>  467
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ipilimumab protein HC with signale peptide

<400>  645

Met Glu Leu Gly Leu Ser Trp Ile Phe Leu Leu Ala Ile Leu Lys Gly 
1               5                   10                  15      


Val Gln Cys Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln 
            20                  25                  30          


Pro Gly Arg Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe 
        35                  40                  45              


Ser Ser Tyr Thr Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu 
    50                  55                  60                  


Glu Trp Val Thr Phe Ile Ser Tyr Asp Gly Asn Asn Lys Tyr Tyr Ala 
65                  70                  75                  80  


Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn 
                85                  90                  95      


Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Ile 
            100                 105                 110         


Tyr Tyr Cys Ala Arg Thr Gly Trp Leu Gly Pro Phe Asp Tyr Trp Gly 
        115                 120                 125             


Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser 
    130                 135                 140                 


Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala 
145                 150                 155                 160 


Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val 
                165                 170                 175     


Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala 
            180                 185                 190         


Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val 
        195                 200                 205             


Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His 
    210                 215                 220                 


Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Pro Lys Ser Cys 
225                 230                 235                 240 


Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
                245                 250                 255     


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
            260                 265                 270         


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
        275                 280                 285             


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
    290                 295                 300                 


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
305                 310                 315                 320 


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
                325                 330                 335     


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
            340                 345                 350         


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
        355                 360                 365             


Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser 
    370                 375                 380                 


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
385                 390                 395                 400 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
                405                 410                 415     


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
            420                 425                 430         


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
        435                 440                 445             


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
    450                 455                 460                 


Pro Gly Lys 
465         


<210>  646
<211>  1404
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Ipilimumab HC with signale peptide

<400>  646
auggagcugg gccucagcug gaucuuccug cuggccaucc ucaagggggu gcagugccag       60

gugcagcugg ucgagagcgg cgggggcgug gugcagcccg ggcgcucccu ccggcugagc      120

ugcgccgccu ccggcuucac cuucagcucc uacaccaugc acuggguccg ccaggcgccg      180

gggaagggcc uggagugggu gacguucauc agcuacgacg gcaacaacaa guacuacgcc      240

gacuccguga aggggcgguu caccaucagc cgcgacaacu ccaagaacac ccucuaccug      300

cagaugaaca gccugcgggc cgaggacacc gccaucuacu acugcgcccg cacgggcugg      360

cucgggcccu ucgacuacug gggccagggg acccugguca ccguguccag cgcguccacc      420

aagggcccca gcguguuccc ccuggccccg uccagcaagu ccacgagcgg cgggaccgcc      480

gcccucggcu gccuggucaa ggacuacuuc cccgagcccg ugaccguguc cuggaacagc      540

ggggcgcuga ccagcggcgu ccacacguuc cccgccgugc uccaguccag cggccuguac      600

ucccugagcu ccguggucac cgugccgagc uccagccucg ggacccagac cuacaucugc      660

aacgugaacc acaagcccuc caacacgaag gucgacaagc ggguggagcc caagagcugc      720

gacaagaccc acacgugccc gcccugcccc gcccccgagc ugcugggcgg gcccuccgug      780

uuccucuucc cgcccaagcc caaggacacc cugaugauca gccgcacccc cgaggugacc      840

ugcgucgugg ucgacguguc ccacgaggac ccggagguca aguucaacug guacguggac      900

ggcguggagg uccacaacgc caagaccaag ccccgggagg agcaguacaa cagcaccuac      960

cgcguggugu ccguccugac ggugcuccac caggacuggc ugaacgggaa ggaguacaag     1020

ugcaagguga gcaacaaggc ccugcccgcg cccaucgaga agaccaucuc caaggccaag     1080

ggccagccgc gggagcccca ggucuacacc cucccgccca gccgcgacga gcugaccaag     1140

aaccaggugu cccugacgug ccucgugaag ggcuucuacc ccagcgacau cgccgucgag     1200

ugggagagca acgggcagcc cgagaacaac uacaagacca cgcccccggu gcuggacucc     1260

gacggcagcu ucuuccugua cuccaagcuc accguggaca agagccggug gcagcagggg     1320

aacgucuucu ccugcagcgu gaugcacgag gcccugcaca accacuacac ccagaagucc     1380

cugagccucu cccccggcaa guga                                            1404


<210>  647
<211>  1404
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Ipilimumab HC with signale peptide

<400>  647
auggagcucg gccucuccug gaucuuccuc cucgccaucc ucaagggcgu ccagugccag       60

guccagcucg ucgaguccgg cggcggcguc guccagcccg gccgcucccu ccgccucucc      120

ugcgccgccu ccggcuucac cuucuccucc uacaccaugc acuggguccg ccaggccccc      180

ggcaagggcc ucgagugggu caccuucauc uccuacgacg gcaacaacaa guacuacgcc      240

gacuccguca agggccgcuu caccaucucc cgcgacaacu ccaagaacac ccucuaccuc      300

cagaugaacu cccuccgcgc cgaggacacc gccaucuacu acugcgcccg caccggcugg      360

cucggccccu ucgacuacug gggccagggc acccucguca ccgucuccuc cgccuccacc      420

aagggccccu ccgucuuccc ccucgccccc uccuccaagu ccaccuccgg cggcaccgcc      480

gcccucggcu gccucgucaa ggacuacuuc cccgagcccg ucaccgucuc cuggaacucc      540

ggcgcccuca ccuccggcgu ccacaccuuc cccgccgucc uccaguccuc cggccucuac      600

ucccucuccu ccgucgucac cguccccucc uccucccucg gcacccagac cuacaucugc      660

aacgucaacc acaagcccuc caacaccaag gucgacaagc gcgucgagcc caaguccugc      720

gacaagaccc acaccugccc ccccugcccc gcccccgagc uccucggcgg ccccuccguc      780

uuccucuucc cccccaagcc caaggacacc cucaugaucu cccgcacccc cgaggucacc      840

ugcgucgucg ucgacgucuc ccacgaggac cccgagguca aguucaacug guacgucgac      900

ggcgucgagg uccacaacgc caagaccaag ccccgcgagg agcaguacaa cuccaccuac      960

cgcgucgucu ccguccucac cguccuccac caggacuggc ucaacggcaa ggaguacaag     1020

ugcaaggucu ccaacaaggc ccuccccgcc cccaucgaga agaccaucuc caaggccaag     1080

ggccagcccc gcgagcccca ggucuacacc cucccccccu cccgcgacga gcucaccaag     1140

aaccaggucu cccucaccug ccucgucaag ggcuucuacc ccuccgacau cgccgucgag     1200

ugggagucca acggccagcc cgagaacaac uacaagacca ccccccccgu ccucgacucc     1260

gacggcuccu ucuuccucua cuccaagcuc accgucgaca agucccgcug gcagcagggc     1320

aacgucuucu ccugcuccgu caugcacgag gcccuccaca accacuacac ccagaagucc     1380

cucucccucu cccccggcaa guga                                            1404


<210>  648
<211>  1404
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Ipilimumab HC with signale peptide

<400>  648
auggagcugg gccucagcug gaucuuccuu cuggccauuu ugaagggggu gcagugccaa       60

guccaguuag uugaauccgg agguggcgug guacagcccg ggagaucucu gaggcuauca      120

ugugcugcaa guggauuuac cuucagcucc uacacaaugc acugggugcg gcaggccccu      180

ggcaaagguc ucgagugggu cacuuuuaua ucuuaugacg ggaacaauaa guacuaugcg      240

gauucgguga aaggacgcuu cacgaucuca cgagacaaca gcaagaauac ccuguaccuu      300

caaaugaaca gucugcgugc ugaagauaca gccauuuauu acugcgcaag aacuggcugg      360

uugggcccau uugacuauug ggggcaggga acccucguua caguguccuc ugccagcacc      420

aaagguccgu ccgucuuccc ccuggcuccu ucaaguaaga gcacuucugg cgggacagca      480

gcccugggau gucucgugaa ggauuacuuu ccagagcccg uaaccguuuc cuggaacuca      540

ggcgcuuuaa cgagcggugu gcauacuuuc ccugccgucc ugcagaguuc ugggcuuuac      600

uccuugagcu cgguggugac cgucccaucu uccucacugg gaacacagac uuauaucugc      660

aauguuaauc acaaacccag uaacaccaag guggacaaaa ggguagaacc uaagagcugu      720

gauaaaacac auaccugccc accguguccc gcgccugagc uacucggcgg cccauccgug      780

uuucuguuuc ccccuaagcc aaaggacacg cuuaugauuu cucggacucc cgaggucaca      840

ugcgugguug uggaugucag ccacgaagac ccggagguga aauuuaauug guacguagau      900

gggguugaag ugcauaacgc aaagaccaaa ccucgcgagg agcaauauaa uucaacuuac      960

agagucguga guguccugac aguguugcac caggacuggc ucaacggaaa ggaauauaaa     1020

uguaagguuu ccaauaaagc ccugcccgcu ccaaucgaga agaccauaag caaggccaaa     1080

ggucagccua gggaacccca gguguacacg uuaccacccu cucgggauga gcugaccaag     1140

aaccaaguau cacucacaug ccuugucaaa ggcuucuauc cuagugacau cgcaguggaa     1200

ugggagagca augggcagcc agagaacaac uacaagacua ccccgcccgu ucuggacucc     1260

gauggaucuu ucuucuugua cucgaaacua acaguggaca agagccgcug gcagcaaggc     1320

aaugucuucu ccuguucagu gaugcacgaa gcucugcaua accacuauac ucagaagagu     1380

cucucucuga gcccugguaa auga                                            1404


<210>  649
<211>  1404
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Ipilimumab HC with signale peptide

<400>  649
auggagcugg gccugagcug gaucuuccug cuggccaucc ugaagggcgu gcagugccag       60

gugcagcugg uggagagcgg cggcggcgug gugcagcccg gcagaagccu gagacugagc      120

ugcgccgcca gcggcuucac cuucagcagc uacaccaugc acugggugag acaggccccc      180

ggcaagggcc uggagugggu gaccuucauc agcuacgacg gcaacaacaa guacuacgcc      240

gacagcguga agggcagauu caccaucagc agagacaaca gcaagaacac ccuguaccug      300

cagaugaaca gccugagagc cgaggacacc gccaucuacu acugcgccag aaccggcugg      360

cugggccccu ucgacuacug gggccagggc acccugguga ccgugagcag cgccagcacc      420

aagggcccca gcguguuccc ccuggccccc agcagcaaga gcaccagcgg cggcaccgcc      480

gcccugggcu gccuggugaa ggacuacuuc cccgagcccg ugaccgugag cuggaacagc      540

ggcgcccuga ccagcggcgu gcacaccuuc cccgccgugc ugcagagcag cggccuguac      600

agccugagca gcguggugac cgugcccagc agcagccugg gcacccagac cuacaucugc      660

aacgugaacc acaagcccag caacaccaag guggacaaga gaguggagcc caagagcugc      720

gacaagaccc acaccugccc ccccugcccc gcccccgagc ugcugggcgg ccccagcgug      780

uuccuguucc cccccaagcc caaggacacc cugaugauca gcagaacccc cgaggugacc      840

ugcguggugg uggacgugag ccacgaggac cccgagguga aguucaacug guacguggac      900

ggcguggagg ugcacaacgc caagaccaag cccagagagg agcaguacaa cagcaccuac      960

agagugguga gcgugcugac cgugcugcac caggacuggc ugaacggcaa ggaguacaag     1020

ugcaagguga gcaacaaggc ccugcccgcc cccaucgaga agaccaucag caaggccaag     1080

ggccagccca gagagcccca gguguacacc cugcccccca gcagagacga gcugaccaag     1140

aaccagguga gccugaccug ccuggugaag ggcuucuacc ccagcgacau cgccguggag     1200

ugggagagca acggccagcc cgagaacaac uacaagacca ccccccccgu gcuggacagc     1260

gacggcagcu ucuuccugua cagcaagcug accguggaca agagcagaug gcagcagggc     1320

aacguguuca gcugcagcgu gaugcacgag gcccugcaca accacuacac ccagaagagc     1380

cugagccuga gccccggcaa guga                                            1404


<210>  650
<211>  1404
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Ipilimumab HC with signale peptide

<400>  650
auggagcugg gccucagcug gaucuuccug cuugccauuc ugaagggggu gcagugccaa       60

guccagcucg uugaauccgg aggcggggug gugcagcccg gaagaucucu gcggcuuagc      120

ugugcugccu ccggcuuuac cuucucuagc uacacaaugc acuggguccg ccaggcgccu      180

gggaaaggac uggagugggu gacguuuauc uccuaugacg gcaacaauaa guacuaugcu      240

gauucuguua aaggcagauu caccauuagc cgggacaacu ccaagaauac acucuaccug      300

caaaugaaca gccugcgcgc cgaagauacc gccaucuauu acugcgcuag aacagggugg      360

cucggaccgu uugacuauug gggccagggg acccugguga cagucucuuc cgccagcacc      420

aaaggacccu cuguguuccc ucuugcuccc uccagcaagu cuacguccgg cgggaccgcc      480

gcgcugggau gucucguuaa ggauuacuuu ccugagcccg ugacagucag cuggaacucc      540

ggcgcccuga ccucuggcgu gcauacauuc ccugcugugc uucagagcuc cgggcuguac      600

agccucucuu ccgucguuac cgugccgagc ucuagccugg gaacgcagac auauauuugc      660

aaugugaauc acaaacccuc caacaccaag gucgacaaac ggguggaacc uaagucuugu      720

gauaaaacac auaccugucc cccuugcccc gccccggagc ugcucggcgg gccuagcguu      780

uuucuguuuc ccccuaagcc caaggacacc cuuaugaucu cccgcacacc cgaggugacg      840

ugcgucgugg uugaugugag ccacgaagac ccugagguca aauucaauug guacguggau      900

ggagucgaag ugcauaacgc uaagaccaaa ccgagagagg agcaauauaa uucuacauac      960

cggguugugu ccguccugac cgugcuccac caggacuggc ugaacggcaa ggaauauaaa     1020

uguaagguua gcaauaaagc ccuucccgcg ccuaucgaga agacaauuuc uaaggccaaa     1080

gggcagcccc gcgaaccuca gguguacacc cugcccccgu ccagagauga gcucacgaag     1140

aaccaaguca gccugacaug ccuggugaaa ggauucuauc cuuccgacau cgcuguggaa     1200

ugggagucua auggccagcc cgagaacaac uacaagacca ccccucccgu ucucgacagc     1260

gauggcuccu uuuuccugua cucuaaacuu acagucgaca agagccggug gcagcaaggg     1320

aauguguucu ccuguagcgu gaugcacgaa gcccugcaua accacuauac ccagaagucu     1380

cucucccuga gcccuggaaa auga                                            1404


<210>  651
<211>  1404
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Ipilimumab HC with signale peptide

<400>  651
auggaauuag guuuauccug gaucuuucuc cuagcaauac ucaaaggagu acaaugccaa       60

guacaauuag uggaauccgg aggaggugua guacaaccag gaagaucacu aagacuauca      120

ugcgcagcau caggauuuac auucucauca uacacaaugc acuggguaag acaagcccca      180

ggaaaaggau uagaaugggu uacauuuaua uccuacgacg gaaacaauaa auacuacgca      240

gacucaguca aaggaagauu cacuauauca agagacaauu cuaaaaacac acuauaccua      300

caaaugaacu cucuccgagc agaagauaca gccauauacu acugcgcaag aacaggaugg      360

uuaggaccuu ucgacuacug gggacaagga acucuaguaa cugucucauc ugccucaaca      420

aaaggcccau caguauuucc acuagcccca ucaucuaaau cuacaucagg uggaaccgcu      480

gcauuaggau gcuuaguaaa agacuauuuu cccgaaccag uaacuguauc uuggaacucc      540

ggagcacuua cuucuggugu acacacauuc ccagcaguuu uacaaagcuc aggacuauac      600

ucucuaagcu caguaguaac ugucccauca ucaucccuug gcacccaaac auacauaugu      660

aacguaaauc acaaacccag uaauaccaaa guagacaaaa gaguagaacc caaaucaugu      720

gauaaaacac acacaugccc ccccugccca gcaccugaac uucuaggagg accaucugua      780

uuccucuucc cuccaaaacc aaaagauacu cucaugauau cacgcacacc cgaaguaacu      840

ugugucguag uagacguauc acacgaagac ccagaaguua aauucaacug guauguagac      900

ggaguagaag uccacaacgc aaaaacaaaa ccacgagaag aacaauacaa cuccaccuau      960

cgcguaguuu caguacuuac aguucuccac caagauuggc uaaacggaaa agaauacaaa     1020

ugcaaaguau caaauaaagc uuuaccugca ccaauagaaa aaacaauaag uaaagcaaaa     1080

ggucaaccac gagaacccca aguauauaca cuuccaccau caagagacga acuuaccaaa     1140

aaccaagucu cacucacaug cuuaguaaaa ggauuuuacc caucagauau agcaguagaa     1200

ugggaaucca auggacaacc agaaaauaau uacaaaacca caccaccugu acuagauuca     1260

gacggcucuu ucuuucuaua cucuaaacua acaguugaua aaucacgaug gcaacaaggc     1320

aauguauucu cuuguucugu caugcaugaa gcacuacaca accacuacac acaaaaauca     1380

cuaucacuau cccccggcaa auga                                            1404


<210>  652
<211>  1404
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Ipilimumab HC with signale peptide

<400>  652
auggagcugg gccucagcug gaucuuccug uuggccauuc ugaagggggu gcagugccaa       60

guccagcucg uggaauccgg uggcggggua gugcagcccg gcaggagucu gcgguugagc      120

ugugcagccu ccgguuuuac cuucaguagc uacacuaugc acuggguccg ccaggcgcca      180

gggaaaggcc uggagugggu gaccuuuauc uccuaugacg gcaacaauaa guacuaugcc      240

gauagcguga aagggagguu cacgauuucc cgggacaaca guaagaauac ucucuaccug      300

caaaugaaca gccugcgcgc agaagauacc gccaucuauu acugcgcaag gaccgguugg      360

cucggcccgu uugacuauug ggggcagggc acucugguca ccguguccag cgccaguacg      420

aaaggucccu ccguauuccc auuggcgccc agcuccaaga guacuagcgg gggcaccgcc      480

gcacugggcu gucucgugaa ggauuacuuu ccagagcccg ucacuguguc cuggaauagc      540

ggggcccuga ccaguggugu gcauaccuuc ccagccgucc ugcaguccag cggcuuguac      600

agucucucca gcgugguaac ggugccgagc uccagucugg ggacucagac cuauauuugc      660

aacgucaauc acaaacccag caacacuaag guggacaaac ggguggaacc aaaguccugu      720

gauaaaaccc auaccugucc cccaugcccc gcaccggagc ugcucggcgg ucccagcguc      780

uuucuguucc cacccaagcc aaaagacacu uugaugauca gucgcacgcc cgaggugacc      840

ugcguagugg ucgauguguc ccacgaagac ccagagguca aguuuaauug guacguggau      900

ggcguggaag uacauaacgc caagacuaaa ccgagggagg agcaauauaa uagcaccuac      960

cggguggucu ccgugcugac cguccuccac caggacuggc ugaacgggaa ggaauauaaa     1020

uguaagguga guaauaaagc gcugcccgcc ccaaucgaga agacuauuag caaggcaaaa     1080

ggccagcccc gcgaaccaca gguguacacg uugcccccgu ccagggauga gcucaccaag     1140

aaccaaguaa gccugacuug ccuggugaaa ggguucuauc caagugacau cgccgucgaa     1200

ugggagucca auggucagcc cgagaacaac uacaagacca cucccccagu gcucgacagc     1260

gauggcuccu ucuuucugua caguaaauug accgucgaca agagccggug gcagcaaggg     1320

aauguguucu ccugcagcgu gaugcacgaa gcacugcaua accacuauac gcagaagagu     1380

cucucccuga gccccggcaa auga                                            1404


<210>  653
<211>  1404
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Ipilimumab HC with signale peptide

<400>  653
auggaacucg gccuaagcug gaucuuccuc cuggccaucc ucaaaggcgu acagugccag       60

guccaacucg uagaauccgg aggcggcguc guacaacccg gccgcucccu ccgccuaucc      120

ugcgcagcuu ccggcuucac auucaguuca uacaccaugc acuggguccg acaagccccc      180

ggcaaaggac ucgaaugggu cacuuuuauc ucuuacgacg gcaacaauaa auacuacgca      240

gacuccguca aaggccgcuu uacaaucuca cgugacaacu ccaaaaacac ccuauaccuc      300

caaaugaacu cccuacgcgc ugaagacacc gccauuuacu auugcgcccg cacaggcugg      360

cuuggaccau ucgacuacug gggacaagga acccuuguca ccgucuccuc ugccagcacc      420

aaaggccccu ccgucuuccc ccucgcuccc agcuccaaau ccacgucagg cggcacugca      480

gcccucggau gccuagucaa agacuacuuc cccgaacccg ucacagucuc auggaacucc      540

ggagcccuca cuucaggcgu ccacaccuuc cccgcaguac uacaaucuuc aggccuauac      600

ucccuaagcu ccgucgucac cguacccucc ucaucccucg gaacacaaac cuacauaugc      660

aacgucaacc acaaacccuc aaacacaaaa guagacaaac gcgucgaacc caaauccugc      720

gacaaaaccc auaccugccc acccugcccc gccccggaac uccuaggcgg ccccagcguc      780

uucuuauucc cacccaaacc caaagacacg cucaugauaa guagaacccc cgaagugacc      840

ugcgucgucg ucgacgucuc ccacgaagac ccugaaguua aauucaacug guacgucgac      900

ggcgucgaag uucacaacgc caaaaccaaa ccccgagaag aacaauacaa cuccaccuac      960

cgagucgucu caguacuaac aguccuccac caagacuggc ucaacggaaa agaauacaaa     1020

ugcaaagucu ccaacaaagc acuaccugcc ccaaucgaga aaacaaucuc caaagccaaa     1080

ggacaacccc gugaacccca gguauacacc cuacccccau cacgcgacga acucaccaaa     1140

aaucagguca gccuaaccug ccucgucaaa ggauucuacc ccuccgacau cgccgucgaa     1200

ugggaaagca acggccaacc cgaaaacaac uacaaaacca ccccacccgu acucgacucc     1260

gacggcuccu ucuuccucua cuccaagcuc accgucgaca aaucccgcug gcaacaggga     1320

aacguauucu ccugcuccgu caugcacgaa gcccuccaca accacuauac ccaaaaauca     1380

cucucccuau cacccggaaa auaa                                            1404


<210>  654
<211>  1404
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Ipilimumab HC with signale peptide

<400>  654
auggaacuag gccuaucaug gaucuuccuc cucgccaucc ucaaaggcgu ccaaugccag       60

guccaacucg ucgaauccgg cggaggcguc guccaacccg gccgaucacu ccgccucucc      120

ugcgccgccu ccggcuucac uuucuccucc uacacaaugc acuggguacg ccaagcccca      180

ggaaaaggac ucgaaugggu caccuucauc uccuacgacg gaaacaacaa auacuacgcc      240

gacagcguua aaggacgauu cacaaucucc cgcgacaacu cuaaaaacac ccuauaccuc      300

caaaugaacu cccuccgcgc cgaagacaca gcaaucuacu acugcgccag aaccggaugg      360

cuaggccccu ucgacuacug gggccaagga acccucguca caguauccuc cgccuccacc      420

aaaggcccuu ccguauuucc ccuggccccc ucauccaaau ccaccagcgg cggaaccgcc      480

gcacuuggcu gccucguaaa agacuacuuc cccgaacccg uaaccgucuc cuggaacagc      540

ggcgcccuaa cgucaggcgu acacaccuuc cccgcagucc uccaauccuc cggacuauau      600

agccucucca gcguaguaac aguacccucc agcucucucg gcacacaaac cuauaucugc      660

aacguaaacc acaaacccag caacaccaaa guugacaaac gcguugaacc caaauccugc      720

gacaaaaccc acacaugccc acccugcccc gcccccgaac uccucggcgg ucccucaguc      780

uuccucuucc caccaaaacc uaaagacacu cuaaugauau cccgcacccc agaagugacc      840

ugcgucguag ucgacgucuc ccacgaagac cccgaaguca aauucaacug guacgucgac      900

ggcgucgaag uacacaacgc caaaaccaaa ccccgagaag aacaauacaa cucaaccuac      960

agagucguca gcguccucac cguccuccau caggacuggc ucaacggaaa agaauacaaa     1020

ugcaaagucu ccaacaaagc ccuaccagca cccauagaga aaaccaucuc caaagccaag     1080

ggccaaccac gcgaacccca aguauacaca cucccacccu cacgagacga acucaccaag     1140

aaccaaguau cuuuaaccug ccuugucaaa ggcuucuacc ccuccgacau cgccguggaa     1200

ugggaaucca acggacaacc cgaaaacaac uacaagacca caccacccgu ccuugacuca     1260

gacggcuccu ucuuccucua uuccaaacuu accgucgaca aaucccgaug gcaacaaggc     1320

aacgucuucu ccugcucagu aaugcacgaa gcccuacaca accacuacac gcaaaaauca     1380

cucucccugu cccccggaaa auga                                            1404


<210>  655
<211>  1404
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Ipilimumab HC with signale peptide

<400>  655
auggaacuug gccuuuccug gaucuuccuc cucgccauac ucaaaggcgu ccaaugccaa       60

guucagcuag ucgaauccgg uggcggcgua guccaacccg gacgcagccu ccgacuaucc      120

ugcgccgccu ccggauucac cuucuccuca uacaccaugc acuggguccg ccaagccccc      180

ggcaaaggcc ucgaaugggu cacauucauc uccuacgaug gaaacaacaa auacuacgcc      240

gacucaguca aaggccgcuu cacaaucucc cgagacaacu ccaaaaacac ccuauaccuc      300

caaaugaacu cacuuagagc cgaagacaca gcaauauacu acugcgcccg caccggaugg      360

cuaggacccu ucgacuacug gggccaaggg acccucguca ccguuagcuc cgccuccaca      420

aaaggacccu ccguauuccc ccucgcccca uccuccaaau ccacaucugg cggcaccgcc      480

gcacucggau gccucguaaa agacuacuuc cccgaacccg ucacagucag cuggaacuca      540

ggcgcucuca ccuccggcgu ccacacauuc ccggcagucc ugcaaagcag cggccucuac      600

ucccuaucau cuguagucac cgucccaucc ucuucccucg gcacccaaac cuacaucugc      660

aacguaaacc acaaacccag caacaccaaa guggauaaac gaguagaacc caaaucuugc      720

gacaaaaccc acacuugccc acccugcccc gccccagaac uucuaggcgg acccuccguc      780

uuccucuucc cacccaaacc caaagacacc cucaugaucu cacgcacccc cgagguaacc      840

ugcguugucg ucgacguguc ccacgaagac ccugaaguca aguucaacug guacgucgac      900

ggcgucgaag ugcacaacgc caaaacaaaa ccacgcgaag aacaauauaa cucaaccuac      960

cgcguagucu ccguccuaac cguccuccac caagacuggc uaaacggcaa agaauacaaa     1020

uguaaaguau ccaauaaagc acuccccgcc cccauagaga aaacgaucuc caaggccaaa     1080

ggucaaccac gcgaacccca aguauacacc cuaccaccau cccgcgacga acucaccaaa     1140

aaccaaguau cccuaaccug ccuagucaaa ggcuucuacc ccuccgacau cgcaguagaa     1200

ugggaaucca acggccaacc agaaaacaac uacaagacaa caccucccgu ccucgacucc     1260

gacggauccu ucuucuuaua cucaaaacua accgucgaca aaucuagaug gcaacaaggc     1320

aacgucuucu caugcuccgu aaugcacgaa gcucuccaca accacuacac ccaaaaauca     1380

cucucccucu cccccggcaa auga                                            1404


<210>  656
<211>  1404
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Ipilimumab HC with signale peptide

<400>  656
auggaacuag gacucucaug gauauuuuua cuagccauac ucaaaggcgu ccaaugucaa       60

guacaacuag uagaaucagg cggaggaguu guccaacccg gccgaucccu ccgcuuauca      120

ugugcagcau cuggauucac auuuucauca uacacaaugc acugggucag acaagcccca      180

ggaaaagguu uagaaugggu aacauuuaua ucauacgacg guaacaacaa auacuaugca      240

gacucaguaa aaggaagauu uacaaucagc agagacaaua gcaaaaacac acuauaccua      300

caaaugaacu cccuacgagc agaagacaca gccaucuauu acugugcacg aacaggaugg      360

cuaggaccau ucgauuacug gggccaagga acauuaguca ccguaucuuc ugcauccaca      420

aaagguccuu caguauuucc auuagcaccc agcuccaaau cuacaucugg cggaacagcc      480

gccuuaggau gcuuaguuaa agauuacuuu ccagaaccag uaacaguuuc auggaacuca      540

ggagcucuaa caucuggagu acacacauuu ccagcagucc uacaaucauc cggacuauau      600

ucacuaucau caguaguaac uguccccuca ucaucauuag gcacacaaac uuauauuugc      660

aauguaaacc auaaaccauc aaauacaaaa gucgacaaaa gaguagaacc aaaaucaugc      720

gacaaaaccc acacaugucc acccugcccc gccccagaau uauuaggagg accaucuguc      780

uuccuuuucc caccaaaacc aaaagacacc uuaaugauau cucgaacucc agaaguaaca      840

uguguaguug uagauguuuc acaugaagac ccagaaguaa aauucaacug guacgucgac      900

ggaguagaag uacacaaugc aaaaacaaaa ccccgagaag aacaauacaa cuccacauac      960

agaguagucu caguacuaac aguacuccau caagacuggc uaaacggaaa agaauacaaa     1020

uguaaaguaa guaauaaagc acuacccgca ccaauagaaa aaacaauauc aaaagcaaaa     1080

ggacaaccaa gagaaccaca aguauauaca cuaccuccau ccagagauga auuaacaaaa     1140

aaccaaguaa gucuaacaug uuuaguaaaa ggauucuauc ccagcgacau agcagucgaa     1200

ugggaaucaa auggacaacc agaaaacaac uauaaaacca caccaccagu auuagauuca     1260

gacggaucau uuuuccuuua cucaaaauua acaguagaca aauccagaug gcaacaaggc     1320

aaugucuuuu caugcucugu caugcacgaa gcucuacaua aucacuacac ucaaaaauca     1380

cuaucacucu caccaggcaa auga                                            1404


<210>  657
<211>  1404
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Ipilimumab HC with signale peptide

<400>  657
auggaacuag gacuauccug gauauuucua cuagccaucc uaaaaggagu acaaugucaa       60

guacaauuag uagaauccgg aggcggagua guccaacccg gaagaucacu aagacucagu      120

ugugcagcau caggauucac auuuucauca uauacaaugc acuggguuag acaagcaccc      180

ggaaaaggac ucgaaugggu aaccuuuauc uccuacgaug gaaacaauaa auauuacgca      240

gauucuguaa aaggccgauu cacaauauca agagacaacu cuaaaaauac auuauaccua      300

caaaugaacu cuuuaagagc agaagacaca gcaauauauu acugugcaag aacaggaugg      360

cucggaccau ucgacuauug gggacaagga accuuaguaa caguauccag cgcuagcaca      420

aaaggcccuu cugucuuccc auuagcacca uccucaaaau caacuucugg cggaacagca      480

gcucuaggau gcuuaguaaa agauuauuuu ccagaaccag uuacuguauc cuggaacuca      540

ggagcacuaa ccaguggagu ucacacauuu ccagccguau uacaaucauc cggauuauau      600

ucauuaucau ccgucguaac cguaccaagc ucaucauuag gaacacaaac auacauaugc      660

aacguaaauc acaaaccauc caauacaaaa guagauaaaa gaguagaacc uaaauccugu      720

gauaaaacac acacaugccc accaugccca gcaccagaau uacuaggagg accaucagua      780

uuccuauucc caccaaaacc aaaagauaca cuaaugauau caagaacacc agaaguaacu      840

uguguagucg uagacgucuc acaugaagac ccagaaguaa aauuuaauug guauguugac      900

ggagucgaag uacacaacgc caaaacaaaa ccacgagaag aacaauacaa cucaacauau      960

agaguaguau cuguauuaac aguauuacau caagauuggu uaaacggaaa agaauacaaa     1020

uguaaaguau caaauaaagc ucuaccagca ccaauagaaa agacaaucuc aaaagcaaaa     1080

ggccaaccuc gagaaccaca aguauacaca cuaccaccau caagagacga auuaaccaaa     1140

aaccaagucu cauuaacaug cuuaguuaaa gguuucuacc ccagcgacau cgcaguugaa     1200

ugggaaucaa acggucaacc ugaaaacaac uauaaaacaa caccaccagu uuuagacuca     1260

gauggauccu uuuucuuaua cucaaaauua acaguugaca aaucaagaug gcaacaagga     1320

aaugucuuuu cauguuccgu caugcaugaa gcacuacaca accauuacac ccaaaaauca     1380

cucucacuau cacccgguaa auaa                                            1404


<210>  658
<211>  1404
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Ipilimumab backbone Rituximab HC with signale peptide

<400>  658
auggagcugg gccucagcug gaucuuccug cuggccaucc ucaagggggu gcagugccag       60

gugcagcugg ucgagagcgg cgggggcgug gugcagcccg ggcgcucccu ccggcugagc      120

ugcgccgccu ccggcuucac cuucagcucc uacaccaugc acuggguccg ccaggcgccg      180

gggaagggcc uggagugggu gacguucauc agcuacgacg gcaacaacaa guacuacgcc      240

gacuccguga aggggcgguu caccaucagc cgcgacaacu ccaagaacac ccucuaccug      300

cagaugaaca gccugcgggc cgaggacacc gccaucuacu acugcgcccg cacgggcugg      360

cucgggcccu ucgacuacug gggccagggg acccugguca ccguguccag cgcguccacc      420

aagggcccca gcguguuccc ccuggccccg uccagcaagu ccacgagcgg cgggaccgcc      480

gcccucggcu gccuggucaa ggacuacuuc cccgagcccg ugaccguguc cuggaacagc      540

ggggcgcuga ccagcggcgu ccacacguuc cccgccgugc uccaguccag cggccuguac      600

ucccugagcu ccguggucac cgugccgagc uccagccucg ggacccagac cuacaucugc      660

aacgugaacc acaagcccuc caacacgaag gucgacaagc ggguggagcc caagagcugc      720

gacaagaccc acacgugccc gcccugcccc gcccccgagc ugcugggcgg cccgagcgug      780

uuccucuucc cgcccaagcc caaggacacc cugaugauca gccgcacccc cgaggucacg      840

ugcguggugg ucgacgugag ccacgaggac cccgagguga aguucaacug guacgucgac      900

gggguggagg ugcacaacgc caagaccaag ccccgggagg agcaguacaa cagcaccuac      960

cgcgucguga gcgugcugac cguccuccac caggacuggc ugaacggcaa ggaguacaag     1020

ugcaaggugu cgaacaaggc ccugccggcc cccaucgaga agacgaucag caaggcgaag     1080

ggccagccgc gggagcccca ggucuacacc cucccgccca gccgcgacga gcugaccaag     1140

aaccaggugu cccugacgug ccucgugaag ggcuucuacc ccagcgacau cgccgucgag     1200

ugggagagca acgggcagcc cgagaacaac uacaagacca cgcccccggu gcuggacucc     1260

gacggcagcu ucuuccugua cuccaagcuc accguggaca agagccggug gcagcagggg     1320

aacgucuucu ccugcagcgu gaugcacgag gcccugcaca accacuacac ccagaagucc     1380

cugagccucu cccccggcaa guga                                            1404


<210>  659
<211>  1404
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Ipilimumab backbone Rituximab HC with signale peptide

<400>  659
auggagcugg gccucagcug gaucuuccuu cuggccauuu ugaagggggu gcagugccaa       60

guccaguuag uugaauccgg agguggcgug guacagcccg ggagaucucu gaggcuauca      120

ugugcugcaa guggauuuac cuucagcucc uacacaaugc acugggugcg gcaggccccu      180

ggcaaagguc ucgagugggu cacuuuuaua ucuuaugacg ggaacaauaa guacuaugcg      240

gauucgguga aaggacgcuu cacgaucuca cgagacaaca gcaagaauac ccuguaccuu      300

caaaugaaca gucugcgugc ugaagauaca gccauuuauu acugcgcaag aacuggcugg      360

uugggcccau uugacuauug ggggcaggga acccucguua caguguccuc ugccagcacc      420

aaagguccgu ccgucuuccc ccuggcuccu ucaaguaaga gcacuucugg cgggacagca      480

gcccugggau gucucgugaa ggauuacuuu ccagagcccg uaaccguuuc cuggaacuca      540

ggcgcuuuaa cgagcggugu gcauacuuuc ccugccgucc ugcagaguuc ugggcuuuac      600

uccuugagcu cgguggugac cgucccaucu uccucacugg gaacacagac uuauaucugc      660

aauguuaauc acaaacccag uaacaccaag guggacaaaa ggguagaacc uaagagcugu      720

gauaaaacac auaccugccc accguguccc gcccccgagc ugcugggcgg cccgagcgug      780

uuccucuucc cgcccaagcc caaggacacc cugaugauca gccgcacccc cgaggucacg      840

ugcguggugg ucgacgugag ccacgaggac cccgagguga aguucaacug guacgucgac      900

gggguggagg ugcacaacgc caagaccaag ccccgggagg agcaguacaa cagcaccuac      960

cgcgucguga gcgugcugac cguccuccac caggacuggc ugaacggcaa ggaguacaag     1020

ugcaaggugu cgaacaaggc ccugccggcc cccaucgaga agacgaucag caaggcgaag     1080

ggucagccua gggaacccca gguguacacg uuaccacccu cucgggauga gcugaccaag     1140

aaccaaguau cacucacaug ccuugucaaa ggcuucuauc cuagugacau cgcaguggaa     1200

ugggagagca augggcagcc agagaacaac uacaagacua ccccgcccgu ucuggacucc     1260

gauggaucuu ucuucuugua cucgaaacua acaguggaca agagccgcug gcagcaaggc     1320

aaugucuucu ccuguucagu gaugcacgaa gcucugcaua accacuauac ucagaagagu     1380

cucucucuga gcccugguaa auga                                            1404


<210>  660
<211>  1404
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Ipilimumab backbone Rituximab HC with signale peptide

<400>  660
auggagcugg gccugagcug gaucuuccug cuggccaucc ugaagggcgu gcagugccag       60

gugcagcugg uggagagcgg cggcggcgug gugcagcccg gcagaagccu gagacugagc      120

ugcgccgcca gcggcuucac cuucagcagc uacaccaugc acugggugag acaggccccc      180

ggcaagggcc uggagugggu gaccuucauc agcuacgacg gcaacaacaa guacuacgcc      240

gacagcguga agggcagauu caccaucagc agagacaaca gcaagaacac ccuguaccug      300

cagaugaaca gccugagagc cgaggacacc gccaucuacu acugcgccag aaccggcugg      360

cugggccccu ucgacuacug gggccagggc acccugguga ccgugagcag cgccagcacc      420

aagggcccca gcguguuccc ccuggccccc agcagcaaga gcaccagcgg cggcaccgcc      480

gcccugggcu gccuggugaa ggacuacuuc cccgagcccg ugaccgugag cuggaacagc      540

ggcgcccuga ccagcggcgu gcacaccuuc cccgccgugc ugcagagcag cggccuguac      600

agccugagca gcguggugac cgugcccagc agcagccugg gcacccagac cuacaucugc      660

aacgugaacc acaagcccag caacaccaag guggacaaga gaguggagcc caagagcugc      720

gacaagaccc acaccugccc ccccugcccc gcccccgagc ugcugggcgg cccgagcgug      780

uuccucuucc cgcccaagcc caaggacacc cugaugauca gccgcacccc cgaggucacg      840

ugcguggugg ucgacgugag ccacgaggac cccgagguga aguucaacug guacgucgac      900

gggguggagg ugcacaacgc caagaccaag ccccgggagg agcaguacaa cagcaccuac      960

cgcgucguga gcgugcugac cguccuccac caggacuggc ugaacggcaa ggaguacaag     1020

ugcaaggugu cgaacaaggc ccugccggcc cccaucgaga agacgaucag caaggcgaag     1080

ggccagccca gagagcccca gguguacacc cugcccccca gcagagacga gcugaccaag     1140

aaccagguga gccugaccug ccuggugaag ggcuucuacc ccagcgacau cgccguggag     1200

ugggagagca acggccagcc cgagaacaac uacaagacca ccccccccgu gcuggacagc     1260

gacggcagcu ucuuccugua cagcaagcug accguggaca agagcagaug gcagcagggc     1320

aacguguuca gcugcagcgu gaugcacgag gcccugcaca accacuacac ccagaagagc     1380

cugagccuga gccccggcaa guga                                            1404


<210>  661
<211>  448
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ipilimumab protein HC without signale peptide

<400>  661

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Thr Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Thr Phe Ile Ser Tyr Asp Gly Asn Asn Lys Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Ile Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Thr Gly Trp Leu Gly Pro Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro 
        115                 120                 125             


Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly 
    130                 135                 140                 


Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn 
145                 150                 155                 160 


Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln 
                165                 170                 175     


Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser 
            180                 185                 190         


Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser 
        195                 200                 205             


Asn Thr Lys Val Asp Lys Arg Val Glu Pro Lys Ser Cys Asp Lys Thr 
    210                 215                 220                 


His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser 
225                 230                 235                 240 


Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg 
                245                 250                 255     


Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro 
            260                 265                 270         


Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala 
        275                 280                 285             


Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val 
    290                 295                 300                 


Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr 
305                 310                 315                 320 


Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr 
                325                 330                 335     


Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu 
            340                 345                 350         


Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys 
        355                 360                 365             


Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser 
    370                 375                 380                 


Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp 
385                 390                 395                 400 


Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser 
                405                 410                 415     


Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala 
            420                 425                 430         


Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440                 445             


<210>  662
<211>  1347
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Ipilimumab HC without signale peptide

<400>  662
caggugcagc uggucgagag cggcgggggc guggugcagc ccgggcgcuc ccuccggcug       60

agcugcgccg ccuccggcuu caccuucagc uccuacacca ugcacugggu ccgccaggcg      120

ccggggaagg gccuggagug ggugacguuc aucagcuacg acggcaacaa caaguacuac      180

gccgacuccg ugaaggggcg guucaccauc agccgcgaca acuccaagaa cacccucuac      240

cugcagauga acagccugcg ggccgaggac accgccaucu acuacugcgc ccgcacgggc      300

uggcucgggc ccuucgacua cuggggccag gggacccugg ucaccguguc cagcgcgucc      360

accaagggcc ccagcguguu cccccuggcc ccguccagca aguccacgag cggcgggacc      420

gccgcccucg gcugccuggu caaggacuac uuccccgagc ccgugaccgu guccuggaac      480

agcggggcgc ugaccagcgg cguccacacg uuccccgccg ugcuccaguc cagcggccug      540

uacucccuga gcuccguggu caccgugccg agcuccagcc ucgggaccca gaccuacauc      600

ugcaacguga accacaagcc cuccaacacg aaggucgaca agcgggugga gcccaagagc      660

ugcgacaaga cccacacgug cccgcccugc cccgcccccg agcugcuggg cgggcccucc      720

guguuccucu ucccgcccaa gcccaaggac acccugauga ucagccgcac ccccgaggug      780

accugcgucg uggucgacgu gucccacgag gacccggagg ucaaguucaa cugguacgug      840

gacggcgugg agguccacaa cgccaagacc aagccccggg aggagcagua caacagcacc      900

uaccgcgugg uguccguccu gacggugcuc caccaggacu ggcugaacgg gaaggaguac      960

aagugcaagg ugagcaacaa ggcccugccc gcgcccaucg agaagaccau cuccaaggcc     1020

aagggccagc cgcgggagcc ccaggucuac acccucccgc ccagccgcga cgagcugacc     1080

aagaaccagg ugucccugac gugccucgug aagggcuucu accccagcga caucgccguc     1140

gagugggaga gcaacgggca gcccgagaac aacuacaaga ccacgccccc ggugcuggac     1200

uccgacggca gcuucuuccu guacuccaag cucaccgugg acaagagccg guggcagcag     1260

gggaacgucu ucuccugcag cgugaugcac gaggcccugc acaaccacua cacccagaag     1320

ucccugagcc ucucccccgg caaguga                                         1347


<210>  663
<211>  1347
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Ipilimumab HC without signale peptide

<400>  663
cagguccagc ucgucgaguc cggcggcggc gucguccagc ccggccgcuc ccuccgccuc       60

uccugcgccg ccuccggcuu caccuucucc uccuacacca ugcacugggu ccgccaggcc      120

cccggcaagg gccucgagug ggucaccuuc aucuccuacg acggcaacaa caaguacuac      180

gccgacuccg ucaagggccg cuucaccauc ucccgcgaca acuccaagaa cacccucuac      240

cuccagauga acucccuccg cgccgaggac accgccaucu acuacugcgc ccgcaccggc      300

uggcucggcc ccuucgacua cuggggccag ggcacccucg ucaccgucuc cuccgccucc      360

accaagggcc ccuccgucuu cccccucgcc cccuccucca aguccaccuc cggcggcacc      420

gccgcccucg gcugccucgu caaggacuac uuccccgagc ccgucaccgu cuccuggaac      480

uccggcgccc ucaccuccgg cguccacacc uuccccgccg uccuccaguc cuccggccuc      540

uacucccucu ccuccgucgu caccgucccc uccuccuccc ucggcaccca gaccuacauc      600

ugcaacguca accacaagcc cuccaacacc aaggucgaca agcgcgucga gcccaagucc      660

ugcgacaaga cccacaccug cccccccugc cccgcccccg agcuccucgg cggccccucc      720

gucuuccucu ucccccccaa gcccaaggac acccucauga ucucccgcac ccccgagguc      780

accugcgucg ucgucgacgu cucccacgag gaccccgagg ucaaguucaa cugguacguc      840

gacggcgucg agguccacaa cgccaagacc aagccccgcg aggagcagua caacuccacc      900

uaccgcgucg ucuccguccu caccguccuc caccaggacu ggcucaacgg caaggaguac      960

aagugcaagg ucuccaacaa ggcccucccc gcccccaucg agaagaccau cuccaaggcc     1020

aagggccagc cccgcgagcc ccaggucuac acccuccccc ccucccgcga cgagcucacc     1080

aagaaccagg ucucccucac cugccucguc aagggcuucu accccuccga caucgccguc     1140

gagugggagu ccaacggcca gcccgagaac aacuacaaga ccaccccccc cguccucgac     1200

uccgacggcu ccuucuuccu cuacuccaag cucaccgucg acaagucccg cuggcagcag     1260

ggcaacgucu ucuccugcuc cgucaugcac gaggcccucc acaaccacua cacccagaag     1320

ucccucuccc ucucccccgg caaguga                                         1347


<210>  664
<211>  1347
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Ipilimumab HC without signale peptide

<400>  664
caggugcaac uggucgagag cggcggggga guugugcagc ccgguagauc ccucaggcuu       60

ucuugcgccg cuucaggcuu caccuuuagu agcuacacaa ugcacugggu acggcaggca      120

ccugggaagg gacuggaaug ggugacuuuc aucuccuaug acggcaacaa uaaauacuau      180

gccgauucug ucaagggucg cuuuacgauu ucgcgagaca acagcaaaaa uaccuuguac      240

uuacagauga acucacugcg ugcggaggau acagcuauau auuacugugc cagaacuggg      300

uggcuaggac cauucgacua uuggggccaa ggcacccucg ugacaguuag uuccgcaucu      360

accaaggggc cgagcguguu uccccuggcc ccuuccucaa aaaguacuag cggagguaca      420

gcugcacuug gcugccuggu caaggauuac uucccagaac ccgugaccgu aucuuggaac      480

uccggggccu ugacgucagg aguucauacu uuuccugcug ugcuccagag caguggccug      540

uacucucugu ccagcgucgu gaccgugcca ucgucuuccc ucgguacaca gacuuauauc      600

uguaauguca aucacaagcc cucaaacacc aaaguugaca agagggugga gccuaaaagu      660

ugcgauaaga cacauaccug uccaccgugc cccgccccug aauuacuugg gggaccaagc      720

guauuccugu uucccccuaa accaaaggac acguugauga uuucccggac ucccgaggug      780

acaugugucg ugguugaugu gucucacgag gacccggaag ucaaguucaa uugguacgug      840

gauggcguag agguucauaa cgcgaaaacc aagccucgcg aagaacagua uaauagcacu      900

uacagagugg ucucagugcu gacaguccua caccaagacu ggcucaacgg caaagaguau      960

aagugcaaag ugaguaauaa ggcacugccc gccccaaucg agaaaaccau uuccaaggcu     1020

aaggggcagc cuagggagcc ccagguuuac acgcuuccac ccagccggga ugaacugacc     1080

aaaaaccagg ugucuuugac augucucgua aagggauuuu auccuucaga caucgccguc     1140

gagugggaaa guaaugguca accagagaac aacuacaaaa cuaccccgcc cgugcuggac     1200

agcgauggcu ccuucuuuuu auacucuaag cugacaguug acaaaucgcg cuggcagcag     1260

gggaaugugu ucagcugcuc cgucaugcac gaggcacucc auaaccacua uacucaaaag     1320

ucacuuaguc ugucuccugg aaaguga                                         1347


<210>  665
<211>  1347
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Ipilimumab HC without signale peptide

<400>  665
caggugcagc ugguggagag cggcggcggc guggugcagc ccggcagaag ccugagacug       60

agcugcgccg ccagcggcuu caccuucagc agcuacacca ugcacugggu gagacaggcc      120

cccggcaagg gccuggagug ggugaccuuc aucagcuacg acggcaacaa caaguacuac      180

gccgacagcg ugaagggcag auucaccauc agcagagaca acagcaagaa cacccuguac      240

cugcagauga acagccugag agccgaggac accgccaucu acuacugcgc cagaaccggc      300

uggcugggcc ccuucgacua cuggggccag ggcacccugg ugaccgugag cagcgccagc      360

accaagggcc ccagcguguu cccccuggcc cccagcagca agagcaccag cggcggcacc      420

gccgcccugg gcugccuggu gaaggacuac uuccccgagc ccgugaccgu gagcuggaac      480

agcggcgccc ugaccagcgg cgugcacacc uuccccgccg ugcugcagag cagcggccug      540

uacagccuga gcagcguggu gaccgugccc agcagcagcc ugggcaccca gaccuacauc      600

ugcaacguga accacaagcc cagcaacacc aagguggaca agagagugga gcccaagagc      660

ugcgacaaga cccacaccug cccccccugc cccgcccccg agcugcuggg cggccccagc      720

guguuccugu ucccccccaa gcccaaggac acccugauga ucagcagaac ccccgaggug      780

accugcgugg ugguggacgu gagccacgag gaccccgagg ugaaguucaa cugguacgug      840

gacggcgugg aggugcacaa cgccaagacc aagcccagag aggagcagua caacagcacc      900

uacagagugg ugagcgugcu gaccgugcug caccaggacu ggcugaacgg caaggaguac      960

aagugcaagg ugagcaacaa ggcccugccc gcccccaucg agaagaccau cagcaaggcc     1020

aagggccagc ccagagagcc ccagguguac acccugcccc ccagcagaga cgagcugacc     1080

aagaaccagg ugagccugac cugccuggug aagggcuucu accccagcga caucgccgug     1140

gagugggaga gcaacggcca gcccgagaac aacuacaaga ccaccccccc cgugcuggac     1200

agcgacggca gcuucuuccu guacagcaag cugaccgugg acaagagcag auggcagcag     1260

ggcaacgugu ucagcugcag cgugaugcac gaggcccugc acaaccacua cacccagaag     1320

agccugagcc ugagccccgg caaguga                                         1347


<210>  666
<211>  1347
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Ipilimumab HC without signale peptide

<400>  666
caggugcaac uggucgagag cggcggggga guugugcagc ccggcagauc ccuccggcug       60

ucuugcgccg cuagcggguu caccuuuucc ucuuacacaa ugcacugggu gcgccaggcc      120

ccuggaaagg gccuugaaug ggucacguuc aucagcuaug acgggaacaa uaaauacuau      180

gcggauuccg ugaagggaag auuuaccauu ucucgggaca acagcaaaaa uacacuguac      240

cuccagauga acucccugcg cgcugaggau accgccaucu auuacugugc cagaacaggc      300

uggcuuggcc cguucgacua uugggggcaa ggaacccugg uuacagugag cucugcuucc      360

accaagggcc ccagcgucuu uccucucgcc cccucuucca aaagcacguc ugggggaacc      420

gcugcccugg gcugccuggu gaaggauuac uucccugaac ccguuacagu guccuggaau      480

agcggggcgc ucaccuccgg aguccauaca uuuccugccg ugcugcaguc uagcggccuu      540

uacucccuga gcucuguggu caccguuccg uccagcucuc ucggcacgca gacauauauu      600

uguaacguga aucacaagcc cagcaacacc aaaguggaca agcgggucga gccuaaaucc      660

ugcgauaaga cacauaccug ucccccuugc cccgcuccgg aacugcuugg gggaccuucu      720

guguuccugu uucccccuaa acccaaggac acccucauga ucagccgcac acccgagguu      780

acgugugugg ucguggaugu uucccacgag gacccugaag ugaaguucaa uugguacguc      840

gauggcgugg agguccauaa cgccaaaacc aagccgagag aagaacagua uaauagcaca      900

uaccgggugg uuucugugcu gaccguccug caccaagacu ggcucaacgg gaaagaguau      960

aagugcaaag uguccaauaa ggcucugccc gccccuauug agaaaacaau cagcaaggcg     1020

aagggacagc cccgcgagcc ucagguuuac acccuucccc cgucuagaga ugaacugacg     1080

aaaaaccagg ugucccucac augucugguc aagggcuuuu auccuagcga caucgccgug     1140

gagugggaau ccaaugggca acccgagaac aacuacaaaa ccaccccucc cgugcuugac     1200

ucugauggca gcuucuuucu guacuccaag cucacaguug acaaaucucg guggcagcag     1260

ggaaaugucu ucagcugcuc cgugaugcac gaggcucugc auaaccacua uacccaaaag     1320

agccugucuc ucuccccugg caaguga                                         1347


<210>  667
<211>  1347
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Ipilimumab HC without signale peptide

<400>  667
caaguucaac uaguagaauc aggaggagga gucguccaac caggcagauc acuaagacua       60

ucaugugcag ccucuggcuu cacauucucu ucuuauacaa ugcacugggu aagacaagca      120

ccaggaaaag gacuagaaug gguaacauuc auaucuuacg acggaaauaa caaauauuac      180

gcugauucug uaaaagguag auucacaauu ucuagagaca auaguaaaaa uacauuauac      240

cuccaaauga auagucuuag agcagaagau acagcaauau acuauugugc acgaacagga      300

ugguuaggac cauucgauua cuggggucaa ggaacauuag uaacaguauc aucugcauca      360

acaaaagguc cuucaguauu cccacucgca ccaucaucaa aauccacauc aggaggaacu      420

gcagcccucg gaugccuagu caaagacuac uucccagaac caguaaccgu aucuuggaac      480

uccggagcau uaacaucugg aguacauaca uucccugcag uacuccaauc aucaggacua      540

uacucacuau ccuccguagu aaccgucccu ucaucaucuc uagguacaca aacuuacaua      600

ugcaacguaa aucacaaacc aucuaauaca aaaguagaca aaagagucga accaaaauca      660

ugcgacaaaa cccacacaug ccccccaugc ccagcacccg aacuacucgg aggaccauca      720

guauuucuau uuccaccaaa accaaaagau acacuaauga uaucacgaac accugaagua      780

accuguguug ucgucgacgu aucgcacgaa gacccagaag uaaaauuuaa uugguacgua      840

gacgguguag aaguucacaa ugcaaaaaca aaaccaagag aagaacaaua caacucaaca      900

uauagaguag uuucugucuu aaccgucuua caccaagauu gguuaaacgg uaaagaauau      960

aaaugcaaag uaucuaauaa agcucuaccc gccccaaucg aaaaaacaau aucaaaagcc     1020

aaaggccaac cucgagaacc acaaguauac acacuacccc cuucaagaga ugaacuaaca     1080

aaaaaccaag uaagccuaac augccuagua aaaggcuuuu auccaucaga cauagcagua     1140

gaaugggaau cuaacgguca accugaaaau aacuauaaaa caacaccacc aguacuagac     1200

ucagauggau cauucuuucu auacucaaaa uuaacaguag auaaaucaag auggcaacaa     1260

ggaaacguuu uuucuuguuc uguaaugcac gaagcacuac acaaucacua uacccaaaaa     1320

ucucucagcc uaucacccgg aaaauga                                         1347


<210>  668
<211>  1347
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Ipilimumab HC without signale peptide

<400>  668
caggugcaac uggucgagag cggcgggggu gugguacagc ccggcagguc ccuccggcug       60

aguugcgccg caagcggguu caccuuuucc aguuacacua ugcacugggu gcgccaggcc      120

ccaggcaagg guuuggaaug ggucaccuuc aucagcuaug acgggaacaa uaaauacuau      180

gcggauuccg ugaagggcag guuuacgauu agccgggaca acuccaaaaa uacucuguac      240

cuccagauga acagucugcg cgccgaggau accgcaaucu auuacugugc caggaccggc      300

ugguuggggc cguucgacua uuggggucaa ggcacucugg ugaccgucag cuccgcaagc      360

acgaaggggc ccaguguguu uccacucgcc cccuccagca aauccaccag uggcgguacc      420

gcggcccugg ggugccuggu aaaggauuac uucccagaac ccgugacugu cagcuggaac      480

uccggcgcac ucaccagcgg cgugcauacc uuuccagccg ugcugcagag uuccggguug      540

uacagccuga guuccgucgu gacgguaccg agcagcuccc ucgguacuca gaccuauauu      600

uguaauguga aucacaagcc caguaacacu aaagucgaca agcgggugga gccaaaaagc      660

ugcgauaaga cccauaccug ucccccaugc cccgccccgg aacugcuggg cgggcccucc      720

guguucuugu uuccacccaa accaaaggac acucucauga ucagccgcac gcccgagguc      780

accugugugg uaguggaugu cagucacgag gacccagaag ugaaauucaa uugguacguc      840

gauggcgugg aggugcauaa cgcaaagacu aagccgaggg aagaacagua uaauuccacc      900

uaccggguag ugagcguccu gaccgugcug caccaagacu ggcucaacgg uaaagaguau      960

aagugcaaag ucuccaauaa ggcccugccc gcgccaauug agaaaacuau caguaaggcc     1020

aagggccagc cccgcgagcc acagguguac acguugcccc cgagcaggga ugaacugacc     1080

aaaaaccagg ugucccucac uugucuggua aagggguuuu auccaagcga caucgcagug     1140

gagugggaaa guaauggcca acccgagaac aacuacaaaa ccacuccccc aguccuggac     1200

uccgauggga gcuucuucuu guacuccaag cucacugugg acaaaagucg guggcagcag     1260

gguaaugucu uuagcugcuc cgugaugcac gaggcccugc auaaccacua uacgcaaaag     1320

agccugaguc ucucccccgg caaguga                                         1347


<210>  669
<211>  1347
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Ipilimumab HC without signale peptide

<400>  669
caaguccagc uaguagaauc cggcggaggc gucguccaac caggacgcuc gcuaagacuc       60

agcugcgccg caucuggcuu cacauucagc ucauacacaa ugcacugggu cagacaagcu      120

ccaggcaaag gccucgaaug ggucacauuc auaucauacg acggcaacaa caaauacuac      180

gccgacuccg uaaaaggccg cuucaccauc uccagagaca acuccaaaaa cacccuauac      240

cuccaaauga acucacucag agccgaagac accgcaaucu acuacugcgc aagaaccggc      300

uggcuuggcc ccuucgauua cuggggacaa ggcacccucg ucaccgucuc auccgcaucc      360

accaaaggcc cauccgucuu cccccucgca ccaucaucca aauccaccag cggagguacc      420

gccgcacucg gcugccuagu caaagacuac uuccccgaac cugucacagu cuccuggaac      480

uccggagccc ugacaucggg cguccacaca uuccccgccg uccuacaaag cuccggccuc      540

uacagccucu ccucagucgu caccguaccc uccuccagcc ucggaacaca aaccuacauc      600

ugcaacguua accacaaacc uuccaacacc aaagucgaca aacgagucga acccaaaucg      660

ugcgacaaaa cccauaccug cccacccugc cccgcccccg aacuccucgg cggcccaucc      720

gucuuccuau ucccacccaa accaaaggac acacucauga uaucacgaac cccugaaguc      780

acgugcgucg ucgucgacgu uucacacgaa gaccccgaag ucaaauucaa cugguacgua      840

gacggagucg aaguccacaa cgccaaaacc aaaccccgag aagaacaaua caacucuacc      900

uaccgcgucg uauccguccu caccguccuc caccaagacu ggcuaaacgg caaagaauac      960

aagugcaaag uuucgaacaa agcccucccc gcacccaucg agaaaaccau cuccaaagcc     1020

aaaggacaac cccgcgaacc ccaaguguac acccucccac ccucgcguga cgaacucacc     1080

aaaaaucaag ucucucuaac cugccucgua aaaggcuucu accccuccga cauagcagua     1140

gaaugggaau cuaacggcca gcccgaaaac aacuacaaaa caaccccacc cguacucgac     1200

uccgacggcu cauucuuccu cuacucaaaa cucaccgucg auaaaucccg cuggcaacaa     1260

ggcaaugucu ucucaugcag cgucaugcac gaagcacucc acaaccacua cacacaaaag     1320

agccucuccc uaucccccgg caaauga                                         1347


<210>  670
<211>  1347
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Ipilimumab HC without signale peptide

<400>  670
caaguccagc uagucgaauc aggcggaggc gucguccaac ccggacgguc ccuacgacuc       60

agcugugcug ccagcggcuu caccuucucg uccuacacaa ugcacugggu ccggcaagca      120

cccggcaaag gucucgaaug ggucaccuuc auauccuaug acggcaacaa caaauacuac      180

gccgacuccg ucaaaggccg cuucacaauc ucaagagaca acuccaaaaa cacccucuac      240

cuccaaauga acucgcuaag agcagaagac accgccaucu acuacugcgc ccgcaccgga      300

uggcucggcc ccuucgacua cuggggccaa ggcacccuag ucacaguauc auccgccucu      360

acaaagggac cauccgucuu cccccucgcc ccauccucca aauccaccuc uggaggcacc      420

gccgcacucg gaugccucgu caaagacuac uuccccgaac ccgucacagu cuccuggaac      480

uccggcgccc uaaccuccgg aguccacaca uucccugcug uccuacaauc cucgggccua      540

uacucccucu caucuguagu caccgucccc ucauccuccc uuggaaccca aacguacaua      600

ugcaacguca accacaaacc uuccaacaca aaagucgaca aacguguaga gccaaagucc      660

ugugacaaaa cacacacaug cccaccaugu cccgcgcccg aacuacucgg cggacccuca      720

gucuuccucu uucccccgaa acccaaagac acccucauga uaucacgcac ccccgaaguu      780

accugcgucg ucgucgacgu cucccacgaa gaccccgaag ucaaauucaa cugguacguc      840

gacggcguag aaguccacaa cgccaaaacc aaaccacggg aagaacaaua caacuccaca      900

uaccgcgucg ucagcguacu caccguccua caucaagacu ggcuaaacgg caaagaauac      960

aaaugcaaag uauccaacaa agcacuccca gcaccaaucg agaaaacaau cucaaaagca     1020

aaaggccaac cccgggaacc acaaguauau acccucccac ccagcagaga cgaacucacc     1080

aaaaaccaag uuucacucac augccucgua aaaggauucu accccucuga cauugcuguc     1140

gaaugggaau ccaacggaca acccgaaaac aacuacaaaa ccaccccgcc cguccucgac     1200

uccgacggcu cauucuuccu auacuccaaa cucaccguag acaaaucccg auggcagcaa     1260

ggcaacgucu ucuccugcag cguaaugcac gaagcacucc acaaccacua uacccaaaaa     1320

ucccucuccc ugucccccgg aaaguaa                                         1347


<210>  671
<211>  1347
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Ipilimumab HC without signale peptide

<400>  671
caaguacaac ucgucgaauc cggcggcggc guaguccaac caggcagauc ccuacgccuc       60

uccugcgccg cauccggauu caccuucucc uccuacacca ugcacugggu acgccaagcc      120

cccggcaagg gccucgaaug ggucacguuc aucucuuacg acggcaacaa caaauacuac      180

gccgacuccg uaaaaggucg uuucaccauc ucccgcgaca acagcaaaaa cacccuauac      240

cuucaaauga acucccuccg cgccgaagac accgccaucu acuacugugc ccgcaccggu      300

uggcucggcc ccuucgacua cuggggucaa ggaacccuag uuaccguauc auccgcaucu      360

accaaaggcc ccuccguauu cccacuagcc ccaucgucca aaucaacauc aggcggcaca      420

gccgcccucg gaugccuagu caaagacuac uuccccgaac ccgucaccgu cucauggaac      480

uccggagccc uaaccucggg aguccacacc uucccagcgg uacuacaauc auccggacuu      540

uacucccuau cauccgucgu cacaguacca uccucauccc ucgggaccca aaccuacaua      600

ugcaacguca accacaaacc auccaacacc aaagucgaca aaagagucga accaaaaucc      660

ugcgacaaaa cccacacaug cccacccugc ccagcccccg aacuccucgg cggccccucc      720

guauuccucu ucccacccaa acccaaggac acccucauga uaucccgcac cccagaagua      780

accugcguag uagucgacgu uucacacgaa gaccccgaag ucaaauucaa cugguacgua      840

gacggcgucg agguccacaa cgccaaaacc aaaccucgcg aagaacaaua caacagcaca      900

uaccgcgucg ucuccguccu aaccguacua caccaagacu ggcuaaacgg caaagaauac      960

aagugcaaag ucuccaacaa agcccucccc gcccccaucg agaaaaccau auccaaagcc     1020

aaaggucaac cccgcgaacc ccaaguauac acccuacccc caucccgcga cgagcucacc     1080

aaaaaccaag uaucccuaac cugccucguc aaaggcuucu accccuccga cauagccguc     1140

gaaugggaaa gcaauggcca gcccgaaaac aacuacaaaa caaccccacc cguccucgac     1200

uccgacggcu cuuucuuccu cuacucaaaa cucacagucg acaaaucacg auggcaacaa     1260

ggcaacgucu ucuccugcag cguaaugcac gaagcccucc acaaccacua cacccaaaaa     1320

ucacucagcc uaagccccgg caaguaa                                         1347


<210>  672
<211>  1347
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Ipilimumab HC without signale peptide

<400>  672
caaguccaac uagucgaauc aggaggaggc guaguacaac caggaagauc cuuaagacuu       60

ucaugugcag caucuggauu uaccuucuca ucauacacaa ugcacugggu cagacaagcc      120

cccggaaaag gacuagaaug gguaacauuu auaucauaug auggaaauaa caaauauuac      180

gcagauucug uaaaaggaag auucaccauc ucaagagaua auucaaaaaa cacacuauac      240

cuacaaauga acucacucag agcugaagac accgcaauau acuauugcgc aagaacagga      300

ugguuaggac cuuucgauua cuggggacaa ggaacacuag uuaccgucuc cuccgcaagu      360

accaaaggac caucuguauu cccauuagca ccaucaucca aaucaacauc aggaggaacc      420

gcagcauuag gaugcuuagu aaaagacuac uuuccugaac ccguaacagu aucauggaau      480

uccggagcac uaacaucagg aguacauacc uuuccagcag uacuccaauc aucaggauua      540

uauuccuuau cuucaguagu aacaguccca ucaucuucac uagguacaca aaccuacauc      600

ugcaauguaa accacaaacc aucaaauaca aaagucgaca aaagaguuga accaaaauca      660

ugugacaaaa cucacacaug cccaccaugu ccagccccag aauuacuagg aggaccauca      720

guauuccuuu ucccaccaaa accaaaagau acucuaauga uaucccguac cccagaagua      780

acaugcgucg uaguagacgu aucacacgaa gaccccgaag uaaaauucaa uugguacguc      840

gacggaguag aaguacacaa cgccaaaaca aaaccccgag aagaacaaua caacuccaca      900

uaccguguag uaucaguauu aacagucuua caccaagacu ggcuaaacgg aaaagaauac      960

aaauguaaag uuuccaacaa agcacuccca gccccuaucg aaaaaaccau aucaaaagca     1020

aaaggccaac ccagagaacc ccaaguuuau acacuaccac caucaagaga cgaauuaaca     1080

aaaaaccaag uaucccuaac augccuagua aaaggauucu acccuucaga caucgcagua     1140

gaaugggaau ccaacggaca accugaaaac aacuauaaaa caacaccacc aguauuagau     1200

agcgauggau cuuucuucuu auauucaaaa cuuacaguag acaaaucucg auggcaacaa     1260

ggaaacguau ucucaugcuc cguaaugcac gaagcgcuac auaaccauua cacacaaaaa     1320

ucacuaucau uaucaccagg aaaauaa                                         1347


<210>  673
<211>  1347
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Ipilimumab HC without signale peptide

<400>  673
caaguucaau uaguagaauc uggaggagga guaguccaac caggacguuc acuaagacuc       60

ucuugugcag cuucaggauu uacguucuca agcuauacca ugcacugggu aagacaagcc      120

ccaggaaaag gauuagaaug gguaacauuu auaucuuacg acggcaauaa caaauauuau      180

gcagacucag uuaaagguag auucacaaua agccgagaca auucaaaaaa cacucuauau      240

cuacaaauga auagccuaag agcagaagau acagcaauau auuacugugc acguacagga      300

ugguuagguc cuuucgauua cuggggacaa gguacucuag uuacaguaag cagcgcaucu      360

accaaaggac caagcguauu cccucuugcu ccaucaagca aauccacauc aggcggaaca      420

gcugcauuag gaugcuuagu aaaagacuau uucccagaac ccguaacggu aucuuggaac      480

agcggcgcau uaacaucagg aguacauacu uuuccugcag uacuacaaag cuccggauua      540

uacucuuuau caucaguagu aacaguacca uccucaucac uaggaacaca aacauauaua      600

uguaacguaa aucauaaacc aucaaacacc aaaguagaca aaagaguaga accaaaauca      660

ugugauaaaa cucacaccug uccuccaugu ccagcacccg aauuauuagg agguccaagu      720

guauucuuau uuccaccaaa accuaaagau acccuaauga uaucaagaac accagaagua      780

acauguguag uaguagacgu cucacacgaa gacccagaag uaaaauucaa cugguacgua      840

gacggaguag aaguacauaa cgcuaaaacu aaaccacgag aagaacaaua caauaguaca      900

uacagaguag ugucaguauu aacaguauua caccaagacu ggcuaaaugg aaaagaauac      960

aaauguaaag uaucaaauaa agcacuacca gcaccaaucg aaaaaaccau cuccaaagcc     1020

aaaggacaac cccgugaacc ucaagucuau acccuaccac ccucaagaga cgaacuuaca     1080

aaaaaccaag uaagcuuaac augucuagua aaaggauucu auccauccga cauagcagua     1140

gaaugggaau caaaugguca accagaaaac aacuacaaaa caacaccacc aguucucgau     1200

ucagauggau cauuuuuucu auauagcaaa uuaacuguag acaaaucuag auggcaacaa     1260

ggaaauguau ucucauguuc aguaaugcau gaagcacucc acaaucauua cacacaaaaa     1320

aguuuaaguu uauccccagg caaauaa                                         1347


<210>  674
<211>  1347
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Ipilimumab backbone Rituximab HC without signale peptide

<400>  674
caggugcagc uggucgagag cggcgggggc guggugcagc ccgggcgcuc ccuccggcug       60

agcugcgccg ccuccggcuu caccuucagc uccuacacca ugcacugggu ccgccaggcg      120

ccggggaagg gccuggagug ggugacguuc aucagcuacg acggcaacaa caaguacuac      180

gccgacuccg ugaaggggcg guucaccauc agccgcgaca acuccaagaa cacccucuac      240

cugcagauga acagccugcg ggccgaggac accgccaucu acuacugcgc ccgcacgggc      300

uggcucgggc ccuucgacua cuggggccag gggacccugg ucaccguguc cagcgcgucc      360

accaagggcc ccagcguguu cccccuggcc ccguccagca aguccacgag cggcgggacc      420

gccgcccucg gcugccuggu caaggacuac uuccccgagc ccgugaccgu guccuggaac      480

agcggggcgc ugaccagcgg cguccacacg uuccccgccg ugcuccaguc cagcggccug      540

uacucccuga gcuccguggu caccgugccg agcuccagcc ucgggaccca gaccuacauc      600

ugcaacguga accacaagcc cuccaacacg aaggucgaca agcgggugga gcccaagagc      660

ugcgacaaga cccacacgug cccgcccugc cccgcccccg agcugcuggg cggcccgagc      720

guguuccucu ucccgcccaa gcccaaggac acccugauga ucagccgcac ccccgagguc      780

acgugcgugg uggucgacgu gagccacgag gaccccgagg ugaaguucaa cugguacguc      840

gacggggugg aggugcacaa cgccaagacc aagccccggg aggagcagua caacagcacc      900

uaccgcgucg ugagcgugcu gaccguccuc caccaggacu ggcugaacgg caaggaguac      960

aagugcaagg ugucgaacaa ggcccugccg gcccccaucg agaagacgau cagcaaggcg     1020

aagggccagc cgcgggagcc ccaggucuac acccucccgc ccagccgcga cgagcugacc     1080

aagaaccagg ugucccugac gugccucgug aagggcuucu accccagcga caucgccguc     1140

gagugggaga gcaacgggca gcccgagaac aacuacaaga ccacgccccc ggugcuggac     1200

uccgacggca gcuucuuccu guacuccaag cucaccgugg acaagagccg guggcagcag     1260

gggaacgucu ucuccugcag cgugaugcac gaggcccugc acaaccacua cacccagaag     1320

ucccugagcc ucucccccgg caaguga                                         1347


<210>  675
<211>  1347
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Ipilimumab backbone Rituximab HC without signale peptide

<400>  675
caggugcaac uggucgagag cggcggggga guugugcagc ccgguagauc ccucaggcuu       60

ucuugcgccg cuucaggcuu caccuuuagu agcuacacaa ugcacugggu acggcaggca      120

ccugggaagg gacuggaaug ggugacuuuc aucuccuaug acggcaacaa uaaauacuau      180

gccgauucug ucaagggucg cuuuacgauu ucgcgagaca acagcaaaaa uaccuuguac      240

uuacagauga acucacugcg ugcggaggau acagcuauau auuacugugc cagaacuggg      300

uggcuaggac cauucgacua uuggggccaa ggcacccucg ugacaguuag uuccgcaucu      360

accaaggggc cgagcguguu uccccuggcc ccuuccucaa aaaguacuag cggagguaca      420

gcugcacuug gcugccuggu caaggauuac uucccagaac ccgugaccgu aucuuggaac      480

uccggggccu ugacgucagg aguucauacu uuuccugcug ugcuccagag caguggccug      540

uacucucugu ccagcgucgu gaccgugcca ucgucuuccc ucgguacaca gacuuauauc      600

uguaauguca aucacaagcc cucaaacacc aaaguugaca agagggugga gccuaaaagu      660

ugcgauaaga cacauaccug uccaccgugc cccgcccccg agcugcuggg cggcccgagc      720

guguuccucu ucccgcccaa gcccaaggac acccugauga ucagccgcac ccccgagguc      780

acgugcgugg uggucgacgu gagccacgag gaccccgagg ugaaguucaa cugguacguc      840

gacggggugg aggugcacaa cgccaagacc aagccccggg aggagcagua caacagcacc      900

uaccgcgucg ugagcgugcu gaccguccuc caccaggacu ggcugaacgg caaggaguac      960

aagugcaagg ugucgaacaa ggcccugccg gcccccaucg agaagacgau cagcaaggcg     1020

aaggggcagc cuagggagcc ccagguuuac acgcuuccac ccagccggga ugaacugacc     1080

aaaaaccagg ugucuuugac augucucgua aagggauuuu auccuucaga caucgccguc     1140

gagugggaaa guaaugguca accagagaac aacuacaaaa cuaccccgcc cgugcuggac     1200

agcgauggcu ccuucuuuuu auacucuaag cugacaguug acaaaucgcg cuggcagcag     1260

gggaaugugu ucagcugcuc cgucaugcac gaggcacucc auaaccacua uacucaaaag     1320

ucacuuaguc ugucuccugg aaaguga                                         1347


<210>  676
<211>  1347
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Ipilimumab backbone Rituximab HC without signale peptide

<400>  676
caggugcagc ugguggagag cggcggcggc guggugcagc ccggcagaag ccugagacug       60

agcugcgccg ccagcggcuu caccuucagc agcuacacca ugcacugggu gagacaggcc      120

cccggcaagg gccuggagug ggugaccuuc aucagcuacg acggcaacaa caaguacuac      180

gccgacagcg ugaagggcag auucaccauc agcagagaca acagcaagaa cacccuguac      240

cugcagauga acagccugag agccgaggac accgccaucu acuacugcgc cagaaccggc      300

uggcugggcc ccuucgacua cuggggccag ggcacccugg ugaccgugag cagcgccagc      360

accaagggcc ccagcguguu cccccuggcc cccagcagca agagcaccag cggcggcacc      420

gccgcccugg gcugccuggu gaaggacuac uuccccgagc ccgugaccgu gagcuggaac      480

agcggcgccc ugaccagcgg cgugcacacc uuccccgccg ugcugcagag cagcggccug      540

uacagccuga gcagcguggu gaccgugccc agcagcagcc ugggcaccca gaccuacauc      600

ugcaacguga accacaagcc cagcaacacc aagguggaca agagagugga gcccaagagc      660

ugcgacaaga cccacaccug cccccccugc cccgcccccg agcugcuggg cggcccgagc      720

guguuccucu ucccgcccaa gcccaaggac acccugauga ucagccgcac ccccgagguc      780

acgugcgugg uggucgacgu gagccacgag gaccccgagg ugaaguucaa cugguacguc      840

gacggggugg aggugcacaa cgccaagacc aagccccggg aggagcagua caacagcacc      900

uaccgcgucg ugagcgugcu gaccguccuc caccaggacu ggcugaacgg caaggaguac      960

aagugcaagg ugucgaacaa ggcccugccg gcccccaucg agaagacgau cagcaaggcg     1020

aagggccagc ccagagagcc ccagguguac acccugcccc ccagcagaga cgagcugacc     1080

aagaaccagg ugagccugac cugccuggug aagggcuucu accccagcga caucgccgug     1140

gagugggaga gcaacggcca gcccgagaac aacuacaaga ccaccccccc cgugcuggac     1200

agcgacggca gcuucuuccu guacagcaag cugaccgugg acaagagcag auggcagcag     1260

ggcaacgugu ucagcugcag cgugaugcac gaggcccugc acaaccacua cacccagaag     1320

agccugagcc ugagccccgg caaguga                                         1347


<210>  677
<211>  235
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ipilimumab protein LC with signale peptide

<400>  677

Met Glu Thr Pro Ala Gln Leu Leu Phe Leu Leu Leu Leu Trp Leu Pro 
1               5                   10                  15      


Asp Thr Thr Gly Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser 
            20                  25                  30          


Leu Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser 
        35                  40                  45              


Val Gly Ser Ser Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala 
    50                  55                  60                  


Pro Arg Leu Leu Ile Tyr Gly Ala Phe Ser Arg Ala Thr Gly Ile Pro 
65                  70                  75                  80  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile 
                85                  90                  95      


Ser Arg Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr 
            100                 105                 110         


Gly Ser Ser Pro Trp Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
        115                 120                 125             


Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
    130                 135                 140                 


Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
145                 150                 155                 160 


Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
                165                 170                 175     


Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
            180                 185                 190         


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
        195                 200                 205             


Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
    210                 215                 220                 


Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230                 235 


<210>  678
<211>  708
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Ipilimumab LC with signale peptide

<400>  678
auggagaccc ccgcccagcu gcucuuccug cugcuccugu ggcugccgga caccacgggc       60

gagaucgugc ugacccagag ccccggcacc cucucccuga gcccggggga gcgcgccacg      120

cuguccugcc gggccagcca guccgucggc agcuccuacc ucgcguggua ccagcagaag      180

cccgggcagg cgccccgccu gcugaucuac ggcgccuuca gccgggccac cgggaucccc      240

gaccgcuucu ccggcagcgg cuccgggacc gacuucaccc ucacgaucag ccggcuggag      300

ccggaggacu ucgccgugua cuacugccag caguacggcu ccagccccug gaccuucggg      360

cagggcacca agguggagau caagcgcacc gucgccgccc ccuccguguu caucuucccg      420

cccagcgacg agcagcugaa guccgggacg gccagcgugg ucugccuccu gaacaacuuc      480

uacccccggg aggccaaggu gcaguggaag guggacaacg cgcugcaguc cggcaacagc      540

caggagagcg ucaccgagca ggacuccaag gacagcaccu acucccucag cuccacccug      600

acgcugagca aggccgacua cgagaagcac aagguguacg ccugcgaggu gacccaccag      660

ggccucucca gccccgucac caaguccuuc aaccgcgggg agugcuga                   708


<210>  679
<211>  708
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Ipilimumab LC with signale peptide

<400>  679
auggagaccc ccgcccagcu ccucuuccuc cuccuccucu ggcuccccga caccaccggc       60

gagaucgucc ucacccaguc ccccggcacc cucucccucu cccccggcga gcgcgccacc      120

cucuccugcc gcgccuccca guccgucggc uccuccuacc ucgccuggua ccagcagaag      180

cccggccagg ccccccgccu ccucaucuac ggcgccuucu cccgcgccac cggcaucccc      240

gaccgcuucu ccggcuccgg cuccggcacc gacuucaccc ucaccaucuc ccgccucgag      300

cccgaggacu ucgccgucua cuacugccag caguacggcu ccucccccug gaccuucggc      360

cagggcacca aggucgagau caagcgcacc gucgccgccc ccuccgucuu caucuucccc      420

cccuccgacg agcagcucaa guccggcacc gccuccgucg ucugccuccu caacaacuuc      480

uacccccgcg aggccaaggu ccaguggaag gucgacaacg cccuccaguc cggcaacucc      540

caggaguccg ucaccgagca ggacuccaag gacuccaccu acucccucuc cuccacccuc      600

acccucucca aggccgacua cgagaagcac aaggucuacg ccugcgaggu cacccaccag      660

ggccucuccu cccccgucac caaguccuuc aaccgcggcg agugcuga                   708


<210>  680
<211>  708
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Ipilimumab LC with signale peptide

<400>  680
auggagaccc ccgcccagcu ucucuuccuu cuguuguuau ggcugccuga cacaacuggc       60

gaaaucgugc uaacgcaaag cccagggacc cucucccugu cuccgggaga gagagcuaca      120

cuuucaugca gggcaaguca gagcgucggu uccucuuacc uggccuggua ucagcagaag      180

cccggccaag cgccucgguu gcucauuuac ggggcuuuuu cgcgcgccac uggaauacca      240

gaucgauucu caggcagcgg uagugggacc gacuuuacac ugaccaucuc ccgucuggaa      300

cccgaggauu ucgcaguuua uuacugucag caguauggau cuagcccuug gacuuuuggc      360

cagggcacaa aaguggaaau uaagagaacc guagccgcuc cauccguguu caucuuuccc      420

ccuucagacg agcaacucaa aagugggacg gcaagcgucg ugugcuuacu gaacaauuuc      480

uacccaaggg aggccaaggu ucaguggaaa guggauaacg cucugcaguc uggaaauucc      540

caggaaucag ucacugagca agacagcaag gauaguaccu auucuuuguc cagcacacug      600

acucuaucga aggccgacua cgaaaaacac aagguguacg cgugugaggu aacccaucag      660

ggucucucuu ccccgguuac aaaaucauuu aaccggggcg agugcuga                   708


<210>  681
<211>  708
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Ipilimumab LC with signale peptide

<400>  681
auggagaccc ccgcccagcu gcuguuccug cugcugcugu ggcugcccga caccaccggc       60

gagaucgugc ugacccagag ccccggcacc cugagccuga gccccggcga gagagccacc      120

cugagcugca gagccagcca gagcgugggc agcagcuacc uggccuggua ccagcagaag      180

cccggccagg cccccagacu gcugaucuac ggcgccuuca gcagagccac cggcaucccc      240

gacagauuca gcggcagcgg cagcggcacc gacuucaccc ugaccaucag cagacuggag      300

cccgaggacu ucgccgugua cuacugccag caguacggca gcagccccug gaccuucggc      360

cagggcacca agguggagau caagagaacc guggccgccc ccagcguguu caucuucccc      420

cccagcgacg agcagcugaa gagcggcacc gccagcgugg ugugccugcu gaacaacuuc      480

uaccccagag aggccaaggu gcaguggaag guggacaacg cccugcagag cggcaacagc      540

caggagagcg ugaccgagca ggacagcaag gacagcaccu acagccugag cagcacccug      600

acccugagca aggccgacua cgagaagcac aagguguacg ccugcgaggu gacccaccag      660

ggccugagca gccccgugac caagagcuuc aacagaggcg agugcuga                   708


<210>  682
<211>  708
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Ipilimumab LC with signale peptide

<400>  682
auggagaccc ccgcccagcu ccuguuccug cuucugcucu ggcugccuga cacaacgggc       60

gaaaucgugc uuacccaaag cccggggaca cugucccucu cucccggaga gagagcuacc      120

cugagcugcc gggccuccca gucugucggc agcuccuacc uggcguggua ucagcagaaa      180

ccugggcaag cuccccgccu ccugauuuac ggagccuuuu cuagagccac aggcaucccu      240

gaucgguuca gcggguccgg aagcggcacc gacuuuacac uuaccauuuc ucgccuggaa      300

cccgaggauu ucgcuguuua uuacugucag caguauggcu ccagcccuug gacguuuggg      360

cagggaacca aaguggaaau caagagaaca guggccgcuc cgucugucuu cauuuuuccc      420

ccuuccgacg agcaacucaa aagcggcacc gccucugugg uuugccugcu uaacaauuuc      480

uacccccggg aggcgaaggu gcaguggaaa gucgauaacg cccugcaguc cgggaauagc      540

caggaauccg ugacagagca agacucuaag gauagcaccu auucccucag cucuacgcug      600

acacugucca aggcugacua cgaaaaacac aagguuuacg ccugugaggu gacccaucag      660

ggacucagcu cuccugucac aaagagcuuu aaccgcggcg agugcuga                   708


<210>  683
<211>  708
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Ipilimumab LC with signale peptide

<400>  683
auggaaacac cagcacaacu acuauucuua cuauuacuau ggcuaccaga cacaacagga       60

gaaauaguac uaacacaauc accaggaaca cuaagucuau caccaggaga aagagcaaca      120

cuaucaugca gagcauccca aucaguugga ucuuccuacc uagccuggua ucaacaaaaa      180

ccaggacaag caccaagauu acuaauauac ggagcauucu caagagcaac uggaauccca      240

gauagauucu caggaucagg aucaggaaca gacuucacau uaacaauauc acgacuagaa      300

ccagaagacu ucgcaguaua cuacugucaa caauacggau ccucaccaug gaccuucggc      360

caaggaacaa aaguagaaau aaaaagaaca guagcagccc caucuguauu cauauuccca      420

ccaucagaug aacaacuaaa aucaggaaca gcaucaguag uaugcuuacu aaacaacuuc      480

uacccaagag aagccaaagu acaauggaaa guagacaacg cacuacaauc aggaaauucc      540

caagaaucag uaacagaaca agacucaaaa gacuccacau acucauuauc aucaacauua      600

acacuaucaa aagcagacua cgaaaaacac aaaguauacg caugugaagu aacacaccaa      660

ggacuaucau caccaguaac aaaaucauuc aaccgaggag aaugcuga                   708


<210>  684
<211>  708
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Ipilimumab LC with signale peptide

<400>  684
auggagaccc ccgcccagcu ccuguuccug uugcugcucu ggcugccaga cacuaccggc       60

gaaaucgugu ugacgcaaag cccggggacu cugucccuca gucccgguga gagggcaacc      120

cugagcugcc gggccuccca gagugucggc agcuccuacc uggcguggua ucagcagaag      180

ccagggcaag caccccgccu ccugauuuac ggcgccuuua gcagggccac cgguauccca      240

gaucgguucu ccgggagugg cagcggcacu gacuuuaccu ugacgauuuc ccgccuggaa      300

cccgaggauu ucgcagugua uuacugucag caguauggga gcaguccaug gacuuuuggu      360

cagggcacca aaguagaaau caagaggacu guggccgcgc cguccgucuu cauuuuuccc      420

ccaagcgacg agcaacucaa auccgggacc gccagugugg ugugccugcu gaacaauuuc      480

uacccccggg aggcaaaggu ccaguggaaa guggauaacg ccuugcagag cggcaauucc      540

caggaaagcg uaaccgagca agacaguaag gauuccacgu auagccucag uuccacucug      600

acccugagca aggccgacua cgaaaaacac aagguguacg caugugaggu cacucaucag      660

ggucucagcu ccccagugac caaaaguuuu aaccgcgggg agugcuga                   708


<210>  685
<211>  708
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Ipilimumab LC with signale peptide

<400>  685
auggaaaccc ccgcccaacu ccucuuccua uuacuccucu ggcuacccga caccaccggc       60

gaaaucgucc ucacccaauc cccaggcacc cucucucucu cccccggaga acgcgcaaca      120

cucuccugcc gugcauccca auccgucgga ucuuccuacc ucgccuggua ccaacaaaaa      180

cccggccaag ccccacgccu ccucaucuac ggcgccuucu cccgcgccac cggcauucca      240

gaccguuucu caggauccgg cuccggcacc gauuucacac ucaccaucuc ccgccuagaa      300

ccagaagacu ucgccguaua cuacugccag caauacggau cuucccccug gacauucggc      360

caaggcacca aagucgaaau caaacgcacc gucgcagccc ccuccgucuu caucuuccca      420

cccuccgacg aacaacuaaa aucuggcaca gcauccgucg ucugccuccu aaacaacuuc      480

uacccccgcg aagccaaagu ccaauggaaa gucgacaacg cacuccaauc uggcaacuca      540

caagaauccg ucacagaaca agacuccaaa gacucaaccu acucccucuc cucaacccuc      600

acccucucca aagccgacua cgaaaaacac aaggucuacg caugcgaagu cacccaucaa      660

ggacucuccu cccccgucac caaauccuuc aaccgcggcg aaugcuaa                   708


<210>  686
<211>  708
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Ipilimumab LC with signale peptide

<400>  686
auggaaacac ccgcccaacu ccucuuccuc cuccuccucu ggcuacccga caccaccggc       60

gaaaucgucc ucacccaauc ccccggcacc cuaucccucu cccccggcga acgcgccacc      120

cuauccugcc gcgcauccca auccguagga uccuccuacc ucgccuggua ccaacaaaaa      180

cccggccaag caccccgccu ccucaucuac ggagccuucu cccgcgccac cggcaucccu      240

gaccgcuucu ccggcucagg cucaggcacc gacuucaccc ucaccaucuc ucgccuagaa      300

cccgaagacu ucgccguaua cuauugccaa caauacggcu ccuccccuug gaccuucggc      360

caaggaacaa aagucgaaau caaacgaacc gucgccgccc ccucagucuu caucuuccca      420

cccuccgacg aacaacucaa auccgguacc gccuccgucg ucugccuucu caacaacuuc      480

uacccccgag aagccaaagu acaauggaaa gucgacaacg cacuacaauc aggcaacucc      540

caagaauccg ucaccgaaca agauuccaaa gacucaaccu acucacucuc cuccacacuc      600

acccucucca aagccgacua cgaaaaacac aaagucuacg ccugcgaagu cacccaccaa      660

ggacucucca gccccgucac caaauccuuc aaccgcggcg aaugcuaa                   708


<210>  687
<211>  708
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Ipilimumab LC with signale peptide

<400>  687
auggaaacuc ccgcccaacu acucuuccuc cuccuccucu ggcuccccga caccaccggc       60

gaaaucgucc uuacccaguc ccccggcacc cucucacucu cccccggcga acgcgccacc      120

cuauccuguc gcgccuccca aucagucggc ucaucauacc ucgccuggua ccaacaaaaa      180

cccggccaag ccccucgccu ccucauauac ggcgccuucu cccgcgccac cggcaucccc      240

gaccgauucu ccggcuccgg cuccggcacu gacuucaccc ucaccauauc ccgccucgaa      300

cccgaagacu ucgcagucua cuacugccaa caauacggau cuucccccug gaccuucggc      360

caaggcacca aagucgaaau caaacgcacc gucgccgccc ccuccgucuu cauauuccca      420

cccucagacg aacaacucaa aucaggcacc gcauccgucg ucugccuccu caacaacuuc      480

uacccccgcg aagccaaagu ccaauggaaa gucgacaacg cccuccaauc aggcaacuca      540

caagaauccg ucacagaaca agacuccaaa gacucaaccu acucccucuc cucaacccuc      600

acacucucca aagccgacua cgaaaaacac aaagucuacg ccugcgaagu cacccaccaa      660

ggacuuuccu cacccgucac caaauccuuc aaccgcggcg aaugcuaa                   708


<210>  688
<211>  708
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Ipilimumab LC with signale peptide

<400>  688
auggaaacac cagcacaacu auuauuccua uuacuucuau ggcuaccaga cacaacagga       60

gaaauaguau uaacacaaag cccaggaaca cucucauuau caccaggaga aagagcaaca      120

cucucaugcc gagcauccca auccgucgga ucaucauauc uagcauggua ccaacaaaaa      180

ccaggacaag cacccagacu acuaauauac ggagcauuuu caagagccac aggaauccca      240

gacagauuuu caggaucagg aucaggaaca gacuucacau uaacaauauc acgauuagaa      300

cccgaagacu ucgcaguaua cuacugccaa caauacggau caucucccug gacauucgga      360

caaggcacaa aaguagaaau aaaacgaaca gucgcagcac caucaguauu cauauuccca      420

ccaucagacg aacaacuaaa aucaggaaca gcaucaguag uaugccuauu aaauaacuuc      480

uacccaagag aagcaaaagu ccaauggaaa guagauaacg cacuacaauc aggaaacucu      540

caagaaucag uaaccgaaca agacucaaaa gauucaaccu acucauuauc aucaacauua      600

acacuaucaa aagcagacua cgaaaaacac aaaguauacg caugcgaagu aacccaccaa      660

ggccuaucau caccaguaac aaaaucauuc aacagaggag aaugcuga                   708


<210>  689
<211>  708
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Ipilimumab LC with signale peptide

<400>  689
auggaaaccc cugcccaauu acuauucuua uuauuacucu ggcuaccaga cacaacagga       60

gaaauaguuu uaacacaauc accaggcaca cuaucacuau caccaggaga aagagcaaca      120

cuaucaugca gagccucaca aucagucgga ucaucauacc uagcauggua ucaacaaaaa      180

cccggacaag caccaagauu auuaauauau ggagcauucu cacgagcaac cggaauacca      240

gauagauucu caggaucagg aagcggcacc gacuucacau uaacaauauc uagacuagaa      300

ccagaagauu ucgcaguaua cuacugccaa caauauggau cuucaccaug gacauucgga      360

caaggaacaa aaguugaaau aaaaagaaca guagcagcac caucaguauu cauauuccca      420

ccaucagacg aacaauuaaa aucaggaaca gccucuguag uaugccuauu aaacaacuuu      480

uacccaagag aagcaaaagu ucaauggaaa guagacaaug cacuacaauc aggcaacuca      540

caagaaucag uaacagaaca agacucuaaa gacucaacau auagccuauc aucaacacuc      600

acccuaucaa aagcagacua cgaaaaacac aaaguauacg caugugaagu aacacaccaa      660

ggacuaucau caccaguaac aaaaucauuc aacagaggag aaugcuaa                   708


<210>  690
<211>  708
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Ipilimumab backbone Rituximab LC with signale peptide

<400>  690
auggagaccc ccgcccagcu gcucuuccug cugcuccugu ggcugccgga caccacgggc       60

gagaucgugc ugacccagag ccccggcacc cucucccuga gcccggggga gcgcgccacg      120

cuguccugcc gggccagcca guccgucggc agcuccuacc ucgcguggua ccagcagaag      180

cccgggcagg cgccccgccu gcugaucuac ggcgccuuca gccgggccac cgggaucccc      240

gaccgcuucu ccggcagcgg cuccgggacc gacuucaccc ucacgaucag ccggcuggag      300

ccggaggacu ucgccgugua cuacugccag caguacggcu ccagccccug gaccuucggg      360

cagggcacca agguggagau caagcgcacc guggcggccc ccagcguguu caucuucccg      420

cccagcgacg agcagcugaa gagcgggacc gccucggucg ugugccuccu gaacaacuuc      480

uacccccggg aggccaaggu gcaguggaag gucgacaacg cgcugcagag cggcaacagc      540

caggagagcg ugacggagca ggacagcaag gacagcaccu acucgcucag cagcacccug      600

acccugagca aggccgacua cgagaagcac aagguguacg ccugcgaggu cacgcaccag      660

gggcucagcu cgcccgugac caagagcuuc aaccgcgggg agugcuga                   708


<210>  691
<211>  708
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Ipilimumab backbone Rituximab LC with signale peptide

<400>  691
auggagaccc ccgcccagcu ucucuuccuu cuguuguuau ggcugccuga cacaacuggc       60

gaaaucgugc uaacgcaaag cccagggacc cucucccugu cuccgggaga gagagcuaca      120

cuuucaugca gggcaaguca gagcgucggu uccucuuacc uggccuggua ucagcagaag      180

cccggccaag cgccucgguu gcucauuuac ggggcuuuuu cgcgcgccac uggaauacca      240

gaucgauucu caggcagcgg uagugggacc gacuuuacac ugaccaucuc ccgucuggaa      300

cccgaggauu ucgcaguuua uuacugucag caguauggau cuagcccuug gacuuuuggc      360

cagggcacaa aaguggaaau uaagagaacc guggcggccc ccagcguguu caucuucccg      420

cccagcgacg agcagcugaa gagcgggacc gccucggucg ugugccuccu gaacaacuuc      480

uacccccggg aggccaaggu gcaguggaag gucgacaacg cgcugcagag cggcaacagc      540

caggagagcg ugacggagca ggacagcaag gacagcaccu acucgcucag cagcacccug      600

acccugagca aggccgacua cgagaagcac aagguguacg ccugcgaggu cacgcaccag      660

gggcucagcu cgcccgugac caagagcuuc aaccgcggcg agugcuga                   708


<210>  692
<211>  708
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Ipilimumab backbone Rituximab LC with signale peptide

<400>  692
auggagaccc ccgcccagcu gcuguuccug cugcugcugu ggcugcccga caccaccggc       60

gagaucgugc ugacccagag ccccggcacc cugagccuga gccccggcga gagagccacc      120

cugagcugca gagccagcca gagcgugggc agcagcuacc uggccuggua ccagcagaag      180

cccggccagg cccccagacu gcugaucuac ggcgccuuca gcagagccac cggcaucccc      240

gacagauuca gcggcagcgg cagcggcacc gacuucaccc ugaccaucag cagacuggag      300

cccgaggacu ucgccgugua cuacugccag caguacggca gcagccccug gaccuucggc      360

cagggcacca agguggagau caagagaacc guggcggccc ccagcguguu caucuucccg      420

cccagcgacg agcagcugaa gagcgggacc gccucggucg ugugccuccu gaacaacuuc      480

uacccccggg aggccaaggu gcaguggaag gucgacaacg cgcugcagag cggcaacagc      540

caggagagcg ugacggagca ggacagcaag gacagcaccu acucgcucag cagcacccug      600

acccugagca aggccgacua cgagaagcac aagguguacg ccugcgaggu cacgcaccag      660

gggcucagcu cgcccgugac caagagcuuc aaccgcggcg agugcuga                   708


<210>  693
<211>  215
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ipilimumab protein LC without signale peptide

<400>  693

Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Gly Ser Ser 
            20                  25                  30          


Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile Tyr Gly Ala Phe Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Ser Ser Pro 
                85                  90                  95      


Trp Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala 
            100                 105                 110         


Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser 
        115                 120                 125             


Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu 
    130                 135                 140                 


Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser 
145                 150                 155                 160 


Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu 
                165                 170                 175     


Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val 
            180                 185                 190         


Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys 
        195                 200                 205             


Ser Phe Asn Arg Gly Glu Cys 
    210                 215 


<210>  694
<211>  648
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Ipilimumab LC without signale peptide

<400>  694
gagaucgugc ugacccagag ccccggcacc cucucccuga gcccggggga gcgcgccacg       60

cuguccugcc gggccagcca guccgucggc agcuccuacc ucgcguggua ccagcagaag      120

cccgggcagg cgccccgccu gcugaucuac ggcgccuuca gccgggccac cgggaucccc      180

gaccgcuucu ccggcagcgg cuccgggacc gacuucaccc ucacgaucag ccggcuggag      240

ccggaggacu ucgccgugua cuacugccag caguacggcu ccagccccug gaccuucggg      300

cagggcacca agguggagau caagcgcacc gucgccgccc ccuccguguu caucuucccg      360

cccagcgacg agcagcugaa guccgggacg gccagcgugg ucugccuccu gaacaacuuc      420

uacccccggg aggccaaggu gcaguggaag guggacaacg cgcugcaguc cggcaacagc      480

caggagagcg ucaccgagca ggacuccaag gacagcaccu acucccucag cuccacccug      540

acgcugagca aggccgacua cgagaagcac aagguguacg ccugcgaggu gacccaccag      600

ggccucucca gccccgucac caaguccuuc aaccgcgggg agugcuga                   648


<210>  695
<211>  648
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Ipilimumab LC without signale peptide

<400>  695
gagaucgucc ucacccaguc ccccggcacc cucucccucu cccccggcga gcgcgccacc       60

cucuccugcc gcgccuccca guccgucggc uccuccuacc ucgccuggua ccagcagaag      120

cccggccagg ccccccgccu ccucaucuac ggcgccuucu cccgcgccac cggcaucccc      180

gaccgcuucu ccggcuccgg cuccggcacc gacuucaccc ucaccaucuc ccgccucgag      240

cccgaggacu ucgccgucua cuacugccag caguacggcu ccucccccug gaccuucggc      300

cagggcacca aggucgagau caagcgcacc gucgccgccc ccuccgucuu caucuucccc      360

cccuccgacg agcagcucaa guccggcacc gccuccgucg ucugccuccu caacaacuuc      420

uacccccgcg aggccaaggu ccaguggaag gucgacaacg cccuccaguc cggcaacucc      480

caggaguccg ucaccgagca ggacuccaag gacuccaccu acucccucuc cuccacccuc      540

acccucucca aggccgacua cgagaagcac aaggucuacg ccugcgaggu cacccaccag      600

ggccucuccu cccccgucac caaguccuuc aaccgcggcg agugcuga                   648


<210>  696
<211>  648
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Ipilimumab LC without signale peptide

<400>  696
gagaucgugc ugacccagag ccccggcaca cucucccuuu cuccugggga aagagccacu       60

cugucaugca gggcuaguca aagcgucgga uccucuuacu uggcauggua ucagcagaag      120

ccaggucagg ccccgcgguu acugauuuac ggcgcguucu cgcgcgcuac ggggauaccc      180

gaccgauuuu caggaagcgg cagugguacc gauuucacac uaacuaucuc ccgucucgag      240

ccugaagacu uugccguuua uuacugucaa caguaugggu cuagcccaug gaccuucgga      300

cagggcacaa aaguggagau uaagagaacc guagcagccc ccuccguguu uaucuucccu      360

ccaucagaug aacagcugaa aaguggcacu gcuagcgucg ugugccuucu gaacaauuuu      420

uaccccaggg aggcaaaggu ucaauggaaa guggacaacg ccuugcaguc uggaaauucc      480

caggagucag ucacagaaca ggauagcaag gacaguaccu auucucucuc cagcacgcug      540

acucugucga aggcugauua cgagaaacac aagguguacg ccugugaagu aacccaucaa      600

gggcucucuu ccccuguuac aaaaucauuc aaccggggug agugcuga                   648


<210>  697
<211>  648
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Ipilimumab LC without signale peptide

<400>  697
gagaucgugc ugacccagag ccccggcacc cugagccuga gccccggcga gagagccacc       60

cugagcugca gagccagcca gagcgugggc agcagcuacc uggccuggua ccagcagaag      120

cccggccagg cccccagacu gcugaucuac ggcgccuuca gcagagccac cggcaucccc      180

gacagauuca gcggcagcgg cagcggcacc gacuucaccc ugaccaucag cagacuggag      240

cccgaggacu ucgccgugua cuacugccag caguacggca gcagccccug gaccuucggc      300

cagggcacca agguggagau caagagaacc guggccgccc ccagcguguu caucuucccc      360

cccagcgacg agcagcugaa gagcggcacc gccagcgugg ugugccugcu gaacaacuuc      420

uaccccagag aggccaaggu gcaguggaag guggacaacg cccugcagag cggcaacagc      480

caggagagcg ugaccgagca ggacagcaag gacagcaccu acagccugag cagcacccug      540

acccugagca aggccgacua cgagaagcac aagguguacg ccugcgaggu gacccaccag      600

ggccugagca gccccgugac caagagcuuc aacagaggcg agugcuga                   648


<210>  698
<211>  648
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Ipilimumab LC without signale peptide

<400>  698
gagaucgugc ugacccagag ccccggcaca cucagccugu cuccugggga aagagccacg       60

cuuagcugcc gggcuuccca aucugucgga agcuccuacc uggccuggua ucagcagaag      120

ccgggccagg cgccccgccu ccugauuuac ggggcuuucu cuagagccac cggaaucccu      180

gaccgguuua gcggcuccgg gagcggaaca gauuucaccc uuacaauuuc ucgccuggag      240

cccgaagacu uugccguuua uuacugucaa caguauggcu ccagcccuug gaccuucggc      300

caggggacaa aaguggagau caagagaacc guggcugccc ccucugucuu uauuuucccu      360

ccguccgaug aacagcucaa aagcggaacg gcuucugugg uuugccugcu gaacaauuuu      420

uacccccggg aggccaaggu gcaauggaaa gucgacaacg cgcuccaguc cggcaauagc      480

caggaguccg ugaccgaaca ggauucuaag gacagcacau auucccugag cucuacccuu      540

acacugucca aggccgauua cgagaaacac aagguuuacg cuugugaagu gacccaucaa      600

gggcucagcu cuccugucac gaaauccuuc aaccgcggag agugcuga                   648


<210>  699
<211>  648
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Ipilimumab LC without signale peptide

<400>  699
gaaauaguac uaacacaauc accaggaacc cucucacuau cuccaggaga aagagcaaca       60

cuaagcugca gagccucaca aucagucgga ucaucauacc uagcauggua ccaacaaaaa      120

ccaggacaag cccccagauu acuaaucuac ggagcauucu cacgagcaac aggaauccca      180

gacagauucu cagguuccgg aucaggaaca gacuucacac uaacaauauc cagauuagaa      240

ccagaagacu ucgcaguaua cuacugccaa caauacggau caucaccaug gacauuugga      300

caaggaacca aaguagaaau caaaagaaca guagcagccc caucaguauu uauauuccca      360

ccaucagacg aacaacuaaa aucaggcacc gcaucaguag uaugucuauu aaacaacuuc      420

uacccaagag aagcaaaagu acaauggaaa guagacaacg cacuacaauc aggaaacucc      480

caagaaucag ucacagaaca agacucaaaa gacucaacau acucacuauc aucaacacua      540

accuuaucaa aagcagacua cgaaaaacac aaaguauacg caugcgaagu aacacaccaa      600

ggauuaucau ccccaguaac aaaaucauuc aacagaggag aaugcuga                   648


<210>  700
<211>  648
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Ipilimumab LC without signale peptide

<400>  700
gagaucgugc ugacccagag ccccggcacu cucucccuga guccagggga aagggccacc       60

uugagcugcc gggcauccca aagugucggu agcuccuacc uggccuggua ucagcagaag      120

ccgggccagg cgccccgccu ccugauuuac ggggccuuca gcagggcaac gggcauccca      180

gaccgguuuu ccgguagugg gagcggcacu gauuucaccu ugaccauuuc ccgccuggag      240

cccgaagacu uugccgugua uuacugucaa caguauggca gcaguccaug gacuuucggg      300

caggguacca aaguagagau caagaggacg guggcagccc ccuccgucuu uauuuuccca      360

ccgagcgaug aacagcucaa auccggcacu gcgagugugg ugugccugcu gaacaauuuu      420

uacccccggg aggccaaggu ccaauggaaa guggacaacg cacuccagag cggcaauucc      480

caggagagcg uaaccgaaca ggauaguaag gacuccacuu auagccugag uuccaccuug      540

acccugagca aggccgauua cgagaaacac aagguguacg ccugugaagu cacgcaucaa      600

gggcucagcu ccccagugac uaaaaguuuc aaccgcggug agugcuga                   648


<210>  701
<211>  648
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Ipilimumab LC without signale peptide

<400>  701
gaaaucgucc uaacccaauc ccccggcaca cuaucucucu ccccaggcga acgcgcaaca       60

cuauccugcc gcgccucaca aucagucggc uccuccuacc uagccuggua ccaacaaaaa      120

cccggccaag caccccgacu ccucaucuac ggcgccuucu cccgcgccac aggcauccca      180

gaccgcuucu ccggcuccgg cuccggcaca gacuucacac ucaccaucuc acgccucgaa      240

cccgaagacu ucgccgucua cuacugccaa caauacggau caucccccug gaccuucgga      300

caaggcacca aagucgaaau caaacgcacc gucgccgccc ccuccgucuu caucuuccca      360

cccucagacg aacaacuaaa auccggcacc gccucaguag ucugccuacu aaacaacuuc      420

uacccccgcg aagccaaagu ccaauggaaa gucgacaacg cccuccaauc cggcaacuca      480

caagaaucag ucaccgaaca agacucaaaa gacuccaccu acucccuauc cuccacccuc      540

acccuaucaa aagccgacua cgaaaaacac aaaguauacg cgugcgaagu aacccaccag      600

ggccuauccu cacccgucac aaaauccuuc aaccgcggcg aaugcuga                   648


<210>  702
<211>  648
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Ipilimumab LC without signale peptide

<400>  702
gaaaucguac uaacccaauc acccggcacc cucucccucu cccccggcga acgagccacc       60

cuaucaugcc gcgccuccca auccguaggc uccuccuacc uagccuggua ccaacaaaaa      120

ccaggccaag caccccgacu acucaucuac ggagccuucu cccgcgccac cggcaucccc      180

gaccgcuucu ccggcuccgg cuccggcacc gacuucaccc ucaccaucuc ccgccucgaa      240

cccgaagacu ucgccgucua cuacugccaa caauacggau caucccccug gaccuucggc      300

caaggcacca aagucgaaau caaacgcacc gucgccgccc ccuccgucuu cauauuccca      360

cccuccgacg aacaacuaaa aucaggaacc gccuccgucg ucugccuacu aaacaacuuc      420

uacccccgcg aagccaaagu acaauggaaa gucgacaacg cccuccaauc cggcaacucc      480

caagaauccg uaaccgaaca agacuccaaa gacucaaccu auucccucuc cuccacacuc      540

acacuaucca aagccgacua cgaaaaacac aaagucuacg ccugcgaagu aacccaccaa      600

ggccucucau cacccgucac caaauccuuc aaccgcggcg aaugcuaa                   648


<210>  703
<211>  648
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Ipilimumab LC without signale peptide

<400>  703
gaaaucgucc ucacccaauc ccccggcacc cuaucacucu cacccggcga acgcgcaacc       60

cucuccugcc gagccuccca auccgucggc uccucauacc ucgccuggua ccaacaaaaa      120

cccggccaag caccccgucu ccucaucuac ggcgccuucu cacgcgccac cggcaucccc      180

gaccgcuucu ccggcucugg cucaggcacc gacuucaccc ucaccaucuc ccgccucgaa      240

cccgaagacu ucgccgucua cuacugccaa caauacggau caucccccug gaccuucggc      300

caaggcacaa aagucgaaau caaacgcacc gucgccgccc cauccgucuu caucuuccca      360

cccuccgacg aacaacucaa auccggcacc gccuccgucg ucugccuccu caacaacuuc      420

uacccccgcg aagccaaagu ccaauggaaa gucgacaacg cccuccaauc cggcaacucc      480

caagaauccg ucaccgaaca agacuccaaa gacuccaccu acucacucuc cuccacccuu      540

acccucucca aagccgacua cgaaaaacac aaagucuacg ccugcgaagu cacccaccaa      600

ggccucuccu cccccgucac caaauccuuc aaccgcggcg aaugcuaa                   648


<210>  704
<211>  648
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Ipilimumab LC without signale peptide

<400>  704
gaaauaguac uaacacaauc accaggaaca cuaucacucu caccuggaga aagagcaaca       60

uuauccugca gagcaucaca aucuguagga ucuucauacc uagcauggua ccaacaaaaa      120

ccaggacaag caccaagauu acuaauauau ggagcauuuu ccagagcaac aggcauacca      180

gacagauucu caggaucagg aucaggaacc gacuucacac uaacaauauc aagacuagaa      240

ccagaagacu ucgcaguaua cuacugccaa caauacggau caucaccaug gacauucgga      300

caaggaacaa aaguagaaau aaaaagaaca gucgcagcac caucaguauu cauauuccca      360

ccaucagacg aacaauuaaa auccggaaca gcaucaguag uaugccuacu aaauaacuuc      420

uacccaagag aagcaaaagu acaauggaaa guagacaacg cauuacaauc aggaaacucc      480

caagaaucag uaacagaaca agacucuaaa gacucaacau acucccuauc aucaacacua      540

acacuaucaa aagcagacua ugaaaaacac aaaguauacg caugcgaagu cacacaucaa      600

ggacuaucau caccaguaac aaaaucauuu aacagaggag aaugcuaa                   648


<210>  705
<211>  648
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Ipilimumab LC without signale peptide

<400>  705
gaaauaguac uaacacaauc accaggaaca uuaucacuau ccccaggaga aagagcaaca       60

uuaucaugca gagcaucaca aucaguagga ucaucauacc uagccuggua ccaacaaaaa      120

ccaggacaag ccccaagauu acuaauauac ggagcauucu caagagcaac aggaauacca      180

gacagauucu cagguucugg cucaggcaca gacuucacac ucacaauauc aagacuagaa      240

ccagaagacu ucgccguaua cuacugccaa caauacggau ccucaccaug gacauucgga      300

caaggaacaa aaguagaaau aaaacgaaca guagcagcac caucaguauu cauauuccca      360

ccaucagacg aacaauuaaa aucaggaaca gcaucaguag uaugccuauu aaacaacuuc      420

uacccacgag aagccaaagu ccaauggaaa guagauaacg cauuacaauc agguaacuca      480

caagaaucag uaacagaaca agacuccaaa gacucaacau acagccuauc aucaacacua      540

acauuaucaa aagcagacua ugaaaaacac aaaguauacg caugcgaggu aacacaccaa      600

ggacuaucau caccaguaac aaaaucauuc aauagaggag aaugcuaa                   648


<210>  706
<211>  215
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ipilimumab backbone Rituximab LC without signale peptide

<400>  706

Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Gly Ser Ser 
            20                  25                  30          


Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile Tyr Gly Ala Phe Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Ser Ser Pro 
                85                  90                  95      


Trp Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala 
            100                 105                 110         


Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser 
        115                 120                 125             


Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu 
    130                 135                 140                 


Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser 
145                 150                 155                 160 


Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu 
                165                 170                 175     


Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val 
            180                 185                 190         


Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys 
        195                 200                 205             


Ser Phe Asn Arg Gly Glu Cys 
    210                 215 


<210>  707
<211>  648
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Ipilimumab backbone Rituximab LC without signale peptide

<400>  707
gagaucgugc ugacccagag ccccggcacc cucucccuga gcccggggga gcgcgccacg       60

cuguccugcc gggccagcca guccgucggc agcuccuacc ucgcguggua ccagcagaag      120

cccgggcagg cgccccgccu gcugaucuac ggcgccuuca gccgggccac cgggaucccc      180

gaccgcuucu ccggcagcgg cuccgggacc gacuucaccc ucacgaucag ccggcuggag      240

ccggaggacu ucgccgugua cuacugccag caguacggcu ccagccccug gaccuucggg      300

cagggcacca agguggagau caagcgcacc guggcggccc ccagcguguu caucuucccg      360

cccagcgacg agcagcugaa gagcgggacc gccucggucg ugugccuccu gaacaacuuc      420

uacccccggg aggccaaggu gcaguggaag gucgacaacg cgcugcagag cggcaacagc      480

caggagagcg ugacggagca ggacagcaag gacagcaccu acucgcucag cagcacccug      540

acccugagca aggccgacua cgagaagcac aagguguacg ccugcgaggu cacgcaccag      600

gggcucagcu cgcccgugac caagagcuuc aaccgcgggg agugcuga                   648


<210>  708
<211>  648
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Ipilimumab backbone Rituximab LC without signale peptide

<400>  708
gagaucgugc ugacccagag ccccggcaca cucucccuuu cuccugggga aagagccacu       60

cugucaugca gggcuaguca aagcgucgga uccucuuacu uggcauggua ucagcagaag      120

ccaggucagg ccccgcgguu acugauuuac ggcgcguucu cgcgcgcuac ggggauaccc      180

gaccgauuuu caggaagcgg cagugguacc gauuucacac uaacuaucuc ccgucucgag      240

ccugaagacu uugccguuua uuacugucaa caguaugggu cuagcccaug gaccuucgga      300

cagggcacaa aaguggagau uaagagaacc guggcggccc ccagcguguu caucuucccg      360

cccagcgacg agcagcugaa gagcgggacc gccucggucg ugugccuccu gaacaacuuc      420

uacccccggg aggccaaggu gcaguggaag gucgacaacg cgcugcagag cggcaacagc      480

caggagagcg ugacggagca ggacagcaag gacagcaccu acucgcucag cagcacccug      540

acccugagca aggccgacua cgagaagcac aagguguacg ccugcgaggu cacgcaccag      600

gggcucagcu cgcccgugac caagagcuuc aaccgcggug agugcuga                   648


<210>  709
<211>  648
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Ipilimumab backbone Rituximab LC without signale peptide

<400>  709
gagaucgugc ugacccagag ccccggcacc cugagccuga gccccggcga gagagccacc       60

cugagcugca gagccagcca gagcgugggc agcagcuacc uggccuggua ccagcagaag      120

cccggccagg cccccagacu gcugaucuac ggcgccuuca gcagagccac cggcaucccc      180

gacagauuca gcggcagcgg cagcggcacc gacuucaccc ugaccaucag cagacuggag      240

cccgaggacu ucgccgugua cuacugccag caguacggca gcagccccug gaccuucggc      300

cagggcacca agguggagau caagagaacc guggcggccc ccagcguguu caucuucccg      360

cccagcgacg agcagcugaa gagcgggacc gccucggucg ugugccuccu gaacaacuuc      420

uacccccggg aggccaaggu gcaguggaag gucgacaacg cgcugcagag cggcaacagc      480

caggagagcg ugacggagca ggacagcaag gacagcaccu acucgcucag cagcacccug      540

acccugagca aggccgacua cgagaagcac aagguguacg ccugcgaggu cacgcaccag      600

gggcucagcu cgcccgugac caagagcuuc aaccgcggcg agugcuga                   648


<210>  710
<211>  2791
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Ipilimumab opt1 IRES construct

<400>  710
auggagcugg gccucagcug gaucuuccug cuggccaucc ucaagggggu gcagugccag       60

gugcagcugg ucgagagcgg cgggggcgug gugcagcccg ggcgcucccu ccggcugagc      120

ugcgccgccu ccggcuucac cuucagcucc uacaccaugc acuggguccg ccaggcgccg      180

gggaagggcc uggagugggu gacguucauc agcuacgacg gcaacaacaa guacuacgcc      240

gacuccguga aggggcgguu caccaucagc cgcgacaacu ccaagaacac ccucuaccug      300

cagaugaaca gccugcgggc cgaggacacc gccaucuacu acugcgcccg cacgggcugg      360

cucgggcccu ucgacuacug gggccagggg acccugguca ccguguccag cgcguccacc      420

aagggcccca gcguguuccc ccuggccccg uccagcaagu ccacgagcgg cgggaccgcc      480

gcccucggcu gccuggucaa ggacuacuuc cccgagcccg ugaccguguc cuggaacagc      540

ggggcgcuga ccagcggcgu ccacacguuc cccgccgugc uccaguccag cggccuguac      600

ucccugagcu ccguggucac cgugccgagc uccagccucg ggacccagac cuacaucugc      660

aacgugaacc acaagcccuc caacacgaag gucgacaagc ggguggagcc caagagcugc      720

gacaagaccc acacgugccc gcccugcccc gcccccgagc ugcugggcgg gcccuccgug      780

uuccucuucc cgcccaagcc caaggacacc cugaugauca gccgcacccc cgaggugacc      840

ugcgucgugg ucgacguguc ccacgaggac ccggagguca aguucaacug guacguggac      900

ggcguggagg uccacaacgc caagaccaag ccccgggagg agcaguacaa cagcaccuac      960

cgcguggugu ccguccugac ggugcuccac caggacuggc ugaacgggaa ggaguacaag     1020

ugcaagguga gcaacaaggc ccugcccgcg cccaucgaga agaccaucuc caaggccaag     1080

ggccagccgc gggagcccca ggucuacacc cucccgccca gccgcgacga gcugaccaag     1140

aaccaggugu cccugacgug ccucgugaag ggcuucuacc ccagcgacau cgccgucgag     1200

ugggagagca acgggcagcc cgagaacaac uacaagacca cgcccccggu gcuggacucc     1260

gacggcagcu ucuuccugua cuccaagcuc accguggaca agagccggug gcagcagggg     1320

aacgucuucu ccugcagcgu gaugcacgag gcccugcaca accacuacac ccagaagucc     1380

cugagccucu cccccggcaa gugaccaugc auuugaaagc cggggguggg agauccggau     1440

ugccagucug cucgauaucg caggcugggu ccgugacuac ccacuccccc uuuaauuccg     1500

ccccucuccc uccccccccc cuaacguuac uggccgaagc cgcuuggaau aaggccggug     1560

ugcguuuguc uauauguuau uuuccaccau auugccgucu uuuggcaaug ugagggcccg     1620

gaaaccuggc ccugucuucu ugacgagcau uccuaggggu cuuuccccuc ucgccaaagg     1680

aaugcaaggu cuguugaaug ucgugaagga agcaguuccu cuggaagcuu cuugaagaca     1740

aacaacgucu guagcgaccc uuugcaggca gcggaacccc ccaccuggcg acaggugccu     1800

cugcggccaa aagccacgug uauaagauac accugcaaag gcggcacaac cccagugcca     1860

cguugugagu uggauaguug uggaaagagu caaauggcuc uccucaagcg uauucaacaa     1920

ggggcugaag gaugcccaga agguacccca uuguauggga ucugaucugg ggccucggug     1980

cacaugcuuu acguguguuu agucgagguu aaaaaacguc uaggcccccc gaaccacggg     2040

gacgugguuu uccuuugaaa aacacgauga uaauagaucu accauggaga cccccgccca     2100

gcugcucuuc cugcugcucc uguggcugcc ggacaccacg ggcgagaucg ugcugaccca     2160

gagccccggc acccucuccc ugagcccggg ggagcgcgcc acgcuguccu gccgggccag     2220

ccaguccguc ggcagcuccu accucgcgug guaccagcag aagcccgggc aggcgccccg     2280

ccugcugauc uacggcgccu ucagccgggc caccgggauc cccgaccgcu ucuccggcag     2340

cggcuccggg accgacuuca cccucacgau cagccggcug gagccggagg acuucgccgu     2400

guacuacugc cagcaguacg gcuccagccc cuggaccuuc gggcagggca ccaaggugga     2460

gaucaagcgc accgucgccg cccccuccgu guucaucuuc ccgcccagcg acgagcagcu     2520

gaaguccggg acggccagcg uggucugccu ccugaacaac uucuaccccc gggaggccaa     2580

ggugcagugg aagguggaca acgcgcugca guccggcaac agccaggaga gcgucaccga     2640

gcaggacucc aaggacagca ccuacucccu cagcuccacc cugacgcuga gcaaggccga     2700

cuacgagaag cacaaggugu acgccugcga ggugacccac cagggccucu ccagccccgu     2760

caccaagucc uucaaccgcg gggagugcug a                                    2791


<210>  711
<211>  2791
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Ipilimumab opt3 IRES construct

<400>  711
auggagcugg gccucagcug gaucuuccuu cuggccauuu ugaagggggu gcagugccaa       60

guccaguuag uugaauccgg agguggcgug guacagcccg ggagaucucu gaggcuauca      120

ugugcugcaa guggauuuac cuucagcucc uacacaaugc acugggugcg gcaggccccu      180

ggcaaagguc ucgagugggu cacuuuuaua ucuuaugacg ggaacaauaa guacuaugcg      240

gauucgguga aaggacgcuu cacgaucuca cgagacaaca gcaagaauac ccuguaccuu      300

caaaugaaca gucugcgugc ugaagauaca gccauuuauu acugcgcaag aacuggcugg      360

uugggcccau uugacuauug ggggcaggga acccucguua caguguccuc ugccagcacc      420

aaagguccgu ccgucuuccc ccuggcuccu ucaaguaaga gcacuucugg cgggacagca      480

gcccugggau gucucgugaa ggauuacuuu ccagagcccg uaaccguuuc cuggaacuca      540

ggcgcuuuaa cgagcggugu gcauacuuuc ccugccgucc ugcagaguuc ugggcuuuac      600

uccuugagcu cgguggugac cgucccaucu uccucacugg gaacacagac uuauaucugc      660

aauguuaauc acaaacccag uaacaccaag guggacaaaa ggguagaacc uaagagcugu      720

gauaaaacac auaccugccc accguguccc gcgccugagc uacucggcgg cccauccgug      780

uuucuguuuc ccccuaagcc aaaggacacg cuuaugauuu cucggacucc cgaggucaca      840

ugcgugguug uggaugucag ccacgaagac ccggagguga aauuuaauug guacguagau      900

gggguugaag ugcauaacgc aaagaccaaa ccucgcgagg agcaauauaa uucaacuuac      960

agagucguga guguccugac aguguugcac caggacuggc ucaacggaaa ggaauauaaa     1020

uguaagguuu ccaauaaagc ccugcccgcu ccaaucgaga agaccauaag caaggccaaa     1080

ggucagccua gggaacccca gguguacacg uuaccacccu cucgggauga gcugaccaag     1140

aaccaaguau cacucacaug ccuugucaaa ggcuucuauc cuagugacau cgcaguggaa     1200

ugggagagca augggcagcc agagaacaac uacaagacua ccccgcccgu ucuggacucc     1260

gauggaucuu ucuucuugua cucgaaacua acaguggaca agagccgcug gcagcaaggc     1320

aaugucuucu ccuguucagu gaugcacgaa gcucugcaua accacuauac ucagaagagu     1380

cucucucuga gcccugguaa augaccaugc auuugaaagc cggggguggg agauccggau     1440

ugccagucug cucgauaucg caggcugggu ccgugacuac ccacuccccc uuuaauuccg     1500

ccccucuccc uccccccccc cuaacguuac uggccgaagc cgcuuggaau aaggccggug     1560

ugcguuuguc uauauguuau uuuccaccau auugccgucu uuuggcaaug ugagggcccg     1620

gaaaccuggc ccugucuucu ugacgagcau uccuaggggu cuuuccccuc ucgccaaagg     1680

aaugcaaggu cuguugaaug ucgugaagga agcaguuccu cuggaagcuu cuugaagaca     1740

aacaacgucu guagcgaccc uuugcaggca gcggaacccc ccaccuggcg acaggugccu     1800

cugcggccaa aagccacgug uauaagauac accugcaaag gcggcacaac cccagugcca     1860

cguugugagu uggauaguug uggaaagagu caaauggcuc uccucaagcg uauucaacaa     1920

ggggcugaag gaugcccaga agguacccca uuguauggga ucugaucugg ggccucggug     1980

cacaugcuuu acguguguuu agucgagguu aaaaaacguc uaggcccccc gaaccacggg     2040

gacgugguuu uccuuugaaa aacacgauga uaauagaucu accauggaga cccccgccca     2100

gcuucucuuc cuucuguugu uauggcugcc ugacacaacu ggcgaaaucg ugcuaacgca     2160

aagcccaggg acccucuccc ugucuccggg agagagagcu acacuuucau gcagggcaag     2220

ucagagcguc gguuccucuu accuggccug guaucagcag aagcccggcc aagcgccucg     2280

guugcucauu uacggggcuu uuucgcgcgc cacuggaaua ccagaucgau ucucaggcag     2340

cgguaguggg accgacuuua cacugaccau cucccgucug gaacccgagg auuucgcagu     2400

uuauuacugu cagcaguaug gaucuagccc uuggacuuuu ggccagggca caaaagugga     2460

aauuaagaga accguagccg cuccauccgu guucaucuuu cccccuucag acgagcaacu     2520

caaaaguggg acggcaagcg ucgugugcuu acugaacaau uucuacccaa gggaggccaa     2580

gguucagugg aaaguggaua acgcucugca gucuggaaau ucccaggaau cagucacuga     2640

gcaagacagc aaggauagua ccuauucuuu guccagcaca cugacucuau cgaaggccga     2700

cuacgaaaaa cacaaggugu acgcguguga gguaacccau cagggucucu cuuccccggu     2760

uacaaaauca uuuaaccggg gcgagugcug a                                    2791


<210>  712
<211>  2791
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Ipilimumab opt4 IRES construct

<400>  712
auggagcugg gccugagcug gaucuuccug cuggccaucc ugaagggcgu gcagugccag       60

gugcagcugg uggagagcgg cggcggcgug gugcagcccg gcagaagccu gagacugagc      120

ugcgccgcca gcggcuucac cuucagcagc uacaccaugc acugggugag acaggccccc      180

ggcaagggcc uggagugggu gaccuucauc agcuacgacg gcaacaacaa guacuacgcc      240

gacagcguga agggcagauu caccaucagc agagacaaca gcaagaacac ccuguaccug      300

cagaugaaca gccugagagc cgaggacacc gccaucuacu acugcgccag aaccggcugg      360

cugggccccu ucgacuacug gggccagggc acccugguga ccgugagcag cgccagcacc      420

aagggcccca gcguguuccc ccuggccccc agcagcaaga gcaccagcgg cggcaccgcc      480

gcccugggcu gccuggugaa ggacuacuuc cccgagcccg ugaccgugag cuggaacagc      540

ggcgcccuga ccagcggcgu gcacaccuuc cccgccgugc ugcagagcag cggccuguac      600

agccugagca gcguggugac cgugcccagc agcagccugg gcacccagac cuacaucugc      660

aacgugaacc acaagcccag caacaccaag guggacaaga gaguggagcc caagagcugc      720

gacaagaccc acaccugccc ccccugcccc gcccccgagc ugcugggcgg ccccagcgug      780

uuccuguucc cccccaagcc caaggacacc cugaugauca gcagaacccc cgaggugacc      840

ugcguggugg uggacgugag ccacgaggac cccgagguga aguucaacug guacguggac      900

ggcguggagg ugcacaacgc caagaccaag cccagagagg agcaguacaa cagcaccuac      960

agagugguga gcgugcugac cgugcugcac caggacuggc ugaacggcaa ggaguacaag     1020

ugcaagguga gcaacaaggc ccugcccgcc cccaucgaga agaccaucag caaggccaag     1080

ggccagccca gagagcccca gguguacacc cugcccccca gcagagacga gcugaccaag     1140

aaccagguga gccugaccug ccuggugaag ggcuucuacc ccagcgacau cgccguggag     1200

ugggagagca acggccagcc cgagaacaac uacaagacca ccccccccgu gcuggacagc     1260

gacggcagcu ucuuccugua cagcaagcug accguggaca agagcagaug gcagcagggc     1320

aacguguuca gcugcagcgu gaugcacgag gcccugcaca accacuacac ccagaagagc     1380

cugagccuga gccccggcaa gugaccaugc auuugaaagc cggggguggg agauccggau     1440

ugccagucug cucgauaucg caggcugggu ccgugacuac ccacuccccc uuuaauuccg     1500

ccccucuccc uccccccccc cuaacguuac uggccgaagc cgcuuggaau aaggccggug     1560

ugcguuuguc uauauguuau uuuccaccau auugccgucu uuuggcaaug ugagggcccg     1620

gaaaccuggc ccugucuucu ugacgagcau uccuaggggu cuuuccccuc ucgccaaagg     1680

aaugcaaggu cuguugaaug ucgugaagga agcaguuccu cuggaagcuu cuugaagaca     1740

aacaacgucu guagcgaccc uuugcaggca gcggaacccc ccaccuggcg acaggugccu     1800

cugcggccaa aagccacgug uauaagauac accugcaaag gcggcacaac cccagugcca     1860

cguugugagu uggauaguug uggaaagagu caaauggcuc uccucaagcg uauucaacaa     1920

ggggcugaag gaugcccaga agguacccca uuguauggga ucugaucugg ggccucggug     1980

cacaugcuuu acguguguuu agucgagguu aaaaaacguc uaggcccccc gaaccacggg     2040

gacgugguuu uccuuugaaa aacacgauga uaauagaucu accauggaga cccccgccca     2100

gcugcuguuc cugcugcugc uguggcugcc cgacaccacc ggcgagaucg ugcugaccca     2160

gagccccggc acccugagcc ugagccccgg cgagagagcc acccugagcu gcagagccag     2220

ccagagcgug ggcagcagcu accuggccug guaccagcag aagcccggcc aggcccccag     2280

acugcugauc uacggcgccu ucagcagagc caccggcauc cccgacagau ucagcggcag     2340

cggcagcggc accgacuuca cccugaccau cagcagacug gagcccgagg acuucgccgu     2400

guacuacugc cagcaguacg gcagcagccc cuggaccuuc ggccagggca ccaaggugga     2460

gaucaagaga accguggccg cccccagcgu guucaucuuc ccccccagcg acgagcagcu     2520

gaagagcggc accgccagcg uggugugccu gcugaacaac uucuacccca gagaggccaa     2580

ggugcagugg aagguggaca acgcccugca gagcggcaac agccaggaga gcgugaccga     2640

gcaggacagc aaggacagca ccuacagccu gagcagcacc cugacccuga gcaaggccga     2700

cuacgagaag cacaaggugu acgccugcga ggugacccac cagggccuga gcagccccgu     2760

gaccaagagc uucaacagag gcgagugcug a                                    2791


<210>  713
<211>  2175
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Ipilimumab opt1 F2A construct

<400>  713
auggagcugg gccucagcug gaucuuccug cuggccaucc ucaagggggu gcagugccag       60

gugcagcugg ucgagagcgg cgggggcgug gugcagcccg ggcgcucccu ccggcugagc      120

ugcgccgccu ccggcuucac cuucagcucc uacaccaugc acuggguccg ccaggcgccg      180

gggaagggcc uggagugggu gacguucauc agcuacgacg gcaacaacaa guacuacgcc      240

gacuccguga aggggcgguu caccaucagc cgcgacaacu ccaagaacac ccucuaccug      300

cagaugaaca gccugcgggc cgaggacacc gccaucuacu acugcgcccg cacgggcugg      360

cucgggcccu ucgacuacug gggccagggg acccugguca ccguguccag cgcguccacc      420

aagggcccca gcguguuccc ccuggccccg uccagcaagu ccacgagcgg cgggaccgcc      480

gcccucggcu gccuggucaa ggacuacuuc cccgagcccg ugaccguguc cuggaacagc      540

ggggcgcuga ccagcggcgu ccacacguuc cccgccgugc uccaguccag cggccuguac      600

ucccugagcu ccguggucac cgugccgagc uccagccucg ggacccagac cuacaucugc      660

aacgugaacc acaagcccuc caacacgaag gucgacaagc ggguggagcc caagagcugc      720

gacaagaccc acacgugccc gcccugcccc gcccccgagc ugcugggcgg gcccuccgug      780

uuccucuucc cgcccaagcc caaggacacc cugaugauca gccgcacccc cgaggugacc      840

ugcgucgugg ucgacguguc ccacgaggac ccggagguca aguucaacug guacguggac      900

ggcguggagg uccacaacgc caagaccaag ccccgggagg agcaguacaa cagcaccuac      960

cgcguggugu ccguccugac ggugcuccac caggacuggc ugaacgggaa ggaguacaag     1020

ugcaagguga gcaacaaggc ccugcccgcg cccaucgaga agaccaucuc caaggccaag     1080

ggccagccgc gggagcccca ggucuacacc cucccgccca gccgcgacga gcugaccaag     1140

aaccaggugu cccugacgug ccucgugaag ggcuucuacc ccagcgacau cgccgucgag     1200

ugggagagca acgggcagcc cgagaacaac uacaagacca cgcccccggu gcuggacucc     1260

gacggcagcu ucuuccugua cuccaagcuc accguggaca agagccggug gcagcagggg     1320

aacgucuucu ccugcagcgu gaugcacgag gcccugcaca accacuacac ccagaagucc     1380

cugagccucu cccccggcaa ggugaagcag acacucaauu ucgaccuucu gaaguuggcu     1440

ggagauguug agucuaaccc aggccccaug gagacccccg cccagcugcu cuuccugcug     1500

cuccuguggc ugccggacac cacgggcgag aucgugcuga cccagagccc cggcacccuc     1560

ucccugagcc cgggggagcg cgccacgcug uccugccggg ccagccaguc cgucggcagc     1620

uccuaccucg cgugguacca gcagaagccc gggcaggcgc cccgccugcu gaucuacggc     1680

gccuucagcc gggccaccgg gauccccgac cgcuucuccg gcagcggcuc cgggaccgac     1740

uucacccuca cgaucagccg gcuggagccg gaggacuucg ccguguacua cugccagcag     1800

uacggcucca gccccuggac cuucgggcag ggcaccaagg uggagaucaa gcgcaccguc     1860

gccgcccccu ccguguucau cuucccgccc agcgacgagc agcugaaguc cgggacggcc     1920

agcguggucu gccuccugaa caacuucuac ccccgggagg ccaaggugca guggaaggug     1980

gacaacgcgc ugcaguccgg caacagccag gagagcguca ccgagcagga cuccaaggac     2040

agcaccuacu cccucagcuc cacccugacg cugagcaagg ccgacuacga gaagcacaag     2100

guguacgccu gcgaggugac ccaccagggc cucuccagcc ccgucaccaa guccuucaac     2160

cgcggggagu gcuga                                                      2175


<210>  714
<211>  2175
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Ipilimumab opt3 F2A construct

<400>  714
auggagcugg gccucagcug gaucuuccuu cuggccauuu ugaagggggu gcagugccaa       60

guccaguuag uugaauccgg agguggcgug guacagcccg ggagaucucu gaggcuauca      120

ugugcugcaa guggauuuac cuucagcucc uacacaaugc acugggugcg gcaggccccu      180

ggcaaagguc ucgagugggu cacuuuuaua ucuuaugacg ggaacaauaa guacuaugcg      240

gauucgguga aaggacgcuu cacgaucuca cgagacaaca gcaagaauac ccuguaccuu      300

caaaugaaca gucugcgugc ugaagauaca gccauuuauu acugcgcaag aacuggcugg      360

uugggcccau uugacuauug ggggcaggga acccucguua caguguccuc ugccagcacc      420

aaagguccgu ccgucuuccc ccuggcuccu ucaaguaaga gcacuucugg cgggacagca      480

gcccugggau gucucgugaa ggauuacuuu ccagagcccg uaaccguuuc cuggaacuca      540

ggcgcuuuaa cgagcggugu gcauacuuuc ccugccgucc ugcagaguuc ugggcuuuac      600

uccuugagcu cgguggugac cgucccaucu uccucacugg gaacacagac uuauaucugc      660

aauguuaauc acaaacccag uaacaccaag guggacaaaa ggguagaacc uaagagcugu      720

gauaaaacac auaccugccc accguguccc gcgccugagc uacucggcgg cccauccgug      780

uuucuguuuc ccccuaagcc aaaggacacg cuuaugauuu cucggacucc cgaggucaca      840

ugcgugguug uggaugucag ccacgaagac ccggagguga aauuuaauug guacguagau      900

gggguugaag ugcauaacgc aaagaccaaa ccucgcgagg agcaauauaa uucaacuuac      960

agagucguga guguccugac aguguugcac caggacuggc ucaacggaaa ggaauauaaa     1020

uguaagguuu ccaauaaagc ccugcccgcu ccaaucgaga agaccauaag caaggccaaa     1080

ggucagccua gggaacccca gguguacacg uuaccacccu cucgggauga gcugaccaag     1140

aaccaaguau cacucacaug ccuugucaaa ggcuucuauc cuagugacau cgcaguggaa     1200

ugggagagca augggcagcc agagaacaac uacaagacua ccccgcccgu ucuggacucc     1260

gauggaucuu ucuucuugua cucgaaacua acaguggaca agagccgcug gcagcaaggc     1320

aaugucuucu ccuguucagu gaugcacgaa gcucugcaua accacuauac ucagaagagu     1380

cucucucuga gcccugguaa agugaagcag acacucaauu ucgaccuucu gaaguuggcu     1440

ggagauguug agucuaaccc aggccccaug gagacccccg cccagcuucu cuuccuucug     1500

uuguuauggc ugccugacac aacuggcgaa aucgugcuaa cgcaaagccc agggacccuc     1560

ucccugucuc cgggagagag agcuacacuu ucaugcaggg caagucagag cgucgguucc     1620

ucuuaccugg ccugguauca gcagaagccc ggccaagcgc cucgguugcu cauuuacggg     1680

gcuuuuucgc gcgccacugg aauaccagau cgauucucag gcagcgguag ugggaccgac     1740

uuuacacuga ccaucucccg ucuggaaccc gaggauuucg caguuuauua cugucagcag     1800

uauggaucua gcccuuggac uuuuggccag ggcacaaaag uggaaauuaa gagaaccgua     1860

gccgcuccau ccguguucau cuuucccccu ucagacgagc aacucaaaag ugggacggca     1920

agcgucgugu gcuuacugaa caauuucuac ccaagggagg ccaagguuca guggaaagug     1980

gauaacgcuc ugcagucugg aaauucccag gaaucaguca cugagcaaga cagcaaggau     2040

aguaccuauu cuuuguccag cacacugacu cuaucgaagg ccgacuacga aaaacacaag     2100

guguacgcgu gugagguaac ccaucagggu cucucuuccc cgguuacaaa aucauuuaac     2160

cggggcgagu gcuga                                                      2175


<210>  715
<211>  2175
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Ipilimumab opt4 F2A construct

<400>  715
auggagcugg gccugagcug gaucuuccug cuggccaucc ugaagggcgu gcagugccag       60

gugcagcugg uggagagcgg cggcggcgug gugcagcccg gcagaagccu gagacugagc      120

ugcgccgcca gcggcuucac cuucagcagc uacaccaugc acugggugag acaggccccc      180

ggcaagggcc uggagugggu gaccuucauc agcuacgacg gcaacaacaa guacuacgcc      240

gacagcguga agggcagauu caccaucagc agagacaaca gcaagaacac ccuguaccug      300

cagaugaaca gccugagagc cgaggacacc gccaucuacu acugcgccag aaccggcugg      360

cugggccccu ucgacuacug gggccagggc acccugguga ccgugagcag cgccagcacc      420

aagggcccca gcguguuccc ccuggccccc agcagcaaga gcaccagcgg cggcaccgcc      480

gcccugggcu gccuggugaa ggacuacuuc cccgagcccg ugaccgugag cuggaacagc      540

ggcgcccuga ccagcggcgu gcacaccuuc cccgccgugc ugcagagcag cggccuguac      600

agccugagca gcguggugac cgugcccagc agcagccugg gcacccagac cuacaucugc      660

aacgugaacc acaagcccag caacaccaag guggacaaga gaguggagcc caagagcugc      720

gacaagaccc acaccugccc ccccugcccc gcccccgagc ugcugggcgg ccccagcgug      780

uuccuguucc cccccaagcc caaggacacc cugaugauca gcagaacccc cgaggugacc      840

ugcguggugg uggacgugag ccacgaggac cccgagguga aguucaacug guacguggac      900

ggcguggagg ugcacaacgc caagaccaag cccagagagg agcaguacaa cagcaccuac      960

agagugguga gcgugcugac cgugcugcac caggacuggc ugaacggcaa ggaguacaag     1020

ugcaagguga gcaacaaggc ccugcccgcc cccaucgaga agaccaucag caaggccaag     1080

ggccagccca gagagcccca gguguacacc cugcccccca gcagagacga gcugaccaag     1140

aaccagguga gccugaccug ccuggugaag ggcuucuacc ccagcgacau cgccguggag     1200

ugggagagca acggccagcc cgagaacaac uacaagacca ccccccccgu gcuggacagc     1260

gacggcagcu ucuuccugua cagcaagcug accguggaca agagcagaug gcagcagggc     1320

aacguguuca gcugcagcgu gaugcacgag gcccugcaca accacuacac ccagaagagc     1380

cugagccuga gccccggcaa ggugaagcag acacucaauu ucgaccuucu gaaguuggcu     1440

ggagauguug agucuaaccc aggccccaug gagacccccg cccagcugcu guuccugcug     1500

cugcuguggc ugcccgacac caccggcgag aucgugcuga cccagagccc cggcacccug     1560

agccugagcc ccggcgagag agccacccug agcugcagag ccagccagag cgugggcagc     1620

agcuaccugg ccugguacca gcagaagccc ggccaggccc ccagacugcu gaucuacggc     1680

gccuucagca gagccaccgg cauccccgac agauucagcg gcagcggcag cggcaccgac     1740

uucacccuga ccaucagcag acuggagccc gaggacuucg ccguguacua cugccagcag     1800

uacggcagca gccccuggac cuucggccag ggcaccaagg uggagaucaa gagaaccgug     1860

gccgccccca gcguguucau cuuccccccc agcgacgagc agcugaagag cggcaccgcc     1920

agcguggugu gccugcugaa caacuucuac cccagagagg ccaaggugca guggaaggug     1980

gacaacgccc ugcagagcgg caacagccag gagagcguga ccgagcagga cagcaaggac     2040

agcaccuaca gccugagcag cacccugacc cugagcaagg ccgacuacga gaagcacaag     2100

guguacgccu gcgaggugac ccaccagggc cugagcagcc ccgugaccaa gagcuucaac     2160

agaggcgagu gcuga                                                      2175


<210>  716
<211>  987
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  IL12B

<400>  716
augugccacc agcagcuggu gaucagcugg uucagccugg uguuccuggc cagcccccug       60

guggccaucu gggagcugaa gaaggacgug uacguggugg agcuggacug guaccccgac      120

gcccccggcg agaugguggu gcugaccugc gacacccccg aggaggacgg caucaccugg      180

acccuggacc agagcagcga ggugcugggc agcggcaaga cccugaccau ccaggugaag      240

gaguucggcg acgccggcca guacaccugc cacaagggcg gcgaggugcu gagccacagc      300

cugcugcugc ugcacaagaa ggaggacggc aucuggagca ccgacauccu gaaggaccag      360

aaggagccca agaacaagac cuuccugaga ugcgaggcca agaacuacag cggcagauuc      420

accugcuggu ggcugaccac caucagcacc gaccugaccu ucagcgugaa gagcagcaga      480

ggcagcagcg acccccaggg cgugaccugc ggcgccgcca cccugagcgc cgagagagug      540

agaggcgaca acaaggagua cgaguacagc guggagugcc aggaggacag cgccugcccc      600

gccgccgagg agagccugcc caucgaggug augguggacg ccgugcacaa gcugaaguac      660

gagaacuaca ccagcagcuu cuucaucaga gacaucauca agcccgaccc ccccaagaac      720

cugcagcuga agccccugaa gaacagcaga cagguggagg ugagcuggga guaccccgac      780

accuggagca ccccccacag cuacuucagc cugaccuucu gcgugcaggu gcagggcaag      840

agcaagagag agaagaagga cagaguguuc accgacaaga ccagcgccac cgugaucugc      900

agaaagaacg ccagcaucag cgugagagcc caggacagau acuacagcag cagcuggagc      960

gagugggcca gcgugcccug cagcuag                                          987


<210>  717
<211>  987
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  IL12B

<400>  717
augugccacc agcagcuggu gaucuccugg uucagccugg uguuccuggc cagcccccug       60

guggccaucu gggagcugaa gaaggaugug uauguggugg agcuggacug guacccagau      120

gccccuggag agaugguggu gcugaccugu gacaccccag aagaagaugg caucaccugg      180

acccuggacc agagcagcga ggugcugggc agcggcaaga cccugaccau ccaggugaag      240

gaguuuggag augcuggcca guacaccugc cacaagggcg gggaggugcu gagccacagc      300

cugcugcugc ugcacaagaa ggaggauggc aucuggagca cagacauccu gaaggaccag      360

aaggagccca agaacaagac cuuccugcgc ugugaggcca agaacuacag cggccgcuuc      420

accugcuggu ggcugaccac caucagcaca gaccugaccu ucucugugaa gagcagccgg      480

ggcagcagug acccccaggg cgugaccugu ggggccgcca cccugucugc ugagcgggug      540

cggggggaca acaaggagua ugaguacagc guggagugcc aggaggacag cgccugccca      600

gcugcugagg agagccugcc caucgaggug augguggaug cugugcacaa gcugaaguau      660

gagaacuaca ccagcagcuu cuucauccgg gacaucauca agccagaccc ccccaagaac      720

cugcagcuga agccccugaa gaacagccgg cagguggagg uguccuggga guacccagac      780

accuggagca ccccccacag cuacuucagc cugaccuucu gugugcaggu gcagggcaag      840

agcaagcggg agaagaagga cagagucuuc acagacaaga ccagcgccac cgucaucugc      900

aggaagaaug ccagcaucuc ugugcgggcc caggaccgcu acuacagcag cuccuggagc      960

gagugggccu cugugcccug cagcuag                                          987


<210>  718
<211>  720
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  IL12A

<400>  718
auguggcccc caggcagcgc cagccagccc ccacccagcc cugcugcugc caccggccug       60

cacccugcug cccggccugu gucccugcag ugccgccugu ccaugugccc agcccggagc      120

cugcugcugg uggccacccu ggugcugcug gaccaccuga gccuggccag gaaccugccu      180

guggccaccc cagaccccgg cauguucccc ugccugcacc acagccagaa ccugcugcgg      240

gcugugagca acaugcugca gaaggcccgg cagacccugg aguucuaccc cugcaccagc      300

gaggagauug accacgagga caucaccaag gacaagacca gcacagugga ggccugccug      360

ccccuggagc ugaccaagaa uggcagcugc cuggccagca ggaagaccag cuucaugaug      420

gcccugugcc ugagcagcau cuaugaggac cugaagaugu accaggugga guucaagacc      480

augaaugcca agcugcugau ggaccccaag aggcagaucu uccuggacca gaacaugcug      540

gccgugauug augagcugau gcaggcccug aacuucaaca gcgagaccgu gccccagaag      600

agcagccugg aggagccaga cuucuacaag accaagauca agcugugcau ccugcugcac      660

gccuuccgca uccgggcugu gaccaucgac agagugauga gcuaccugaa ugccagcuag      720


<210>  719
<211>  720
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  IL12A

<400>  719
auguggcccc caggcagcgc cagccagccc ccacccagcc cugcugcugc caccggccug       60

cacccugcug cccggccugu gucccugcag ugccgccugu ccaugugccc agcccggagc      120

cugcugcugg uggccacccu ggugcugcug gaccaccuga gccuggccag gaaccugccu      180

guggccaccc cagaccccgg cauguucccc ugccugcacc acagccagaa ccugcugcgg      240

gcugugagca acaugcugca gaaggcccgg cagacccugg aguucuaccc cugcaccagc      300

gaggagauug accacgagga caucaccaag gacaagacca gcacagugga ggccugccug      360

ccccuggagc ugaccaagaa uggcagcugc cuggccagca ggaagaccag cuucaugaug      420

gcccugugcc ugagcagcau cuaugaggac cugaagaugu accaggugga guucaagacc      480

augaaugcca agcugcugau ggaccccaag aggcagaucu uccuggacca gaacaugcug      540

gccgugauug augagcugau gcaggcccug aacuucaaca gcgagaccgu gccccagaag      600

agcagccugg aggagccaga cuucuacaag accaagauca agcugugcau ccugcugcac      660

gccuuccgca uccgggcugu gaccaucgac agagugauga gcuaccugaa ugccagcuag      720


<210>  720
<211>  720
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  IL12A

<400>  720
auguggcccc ccggcagcgc cagccagccc ccccccagcc ccgccgccgc caccggccug       60

caccccgccg ccagacccgu gagccugcag ugcagacuga gcaugugccc cgccagaagc      120

cugcugcugg uggccacccu ggugcugcug gaccaccuga gccuggccag aaaccugccc      180

guggccaccc ccgaccccgg cauguucccc ugccugcacc acagccagaa ccugcugaga      240

gccgugagca acaugcugca gaaggccaga cagacccugg aguucuaccc cugcaccagc      300

gaggagaucg accacgagga caucaccaag gacaagacca gcaccgugga ggccugccug      360

ccccuggagc ugaccaagaa cggcagcugc cuggccagca gaaagaccag cuucaugaug      420

gcccugugcc ugagcagcau cuacgaggac cugaagaugu accaggugga guucaagacc      480

augaacgcca agcugcugau ggaccccaag agacagaucu uccuggacca gaacaugcug      540

gccgugaucg acgagcugau gcaggcccug aacuucaaca gcgagaccgu gccccagaag      600

agcagccugg aggagcccga cuucuacaag accaagauca agcugugcau ccugcugcac      660

gccuucagaa ucagagccgu gaccaucgac agagugauga gcuaccugaa cgccagcuag      720


<210>  721
<211>  720
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  IL12A

<400>  721
auguggcccc ccggcagcgc cagccagccc ccccccagcc ccgccgccgc caccggccug       60

caccccgccg ccagacccgu gagccugcag ugcagacuga gcaugugccc cgccagaagc      120

cugcugcugg uggccacccu ggugcugcug gaccaccuga gccuggccag aaaccugccc      180

guggccaccc ccgaccccgg cauguucccc ugccugcacc acagccagaa ccugcugaga      240

gccgugagca acaugcugca gaaggccaga cagacccugg aguucuaccc cugcaccagc      300

gaggagaucg accacgagga caucaccaag gacaagacca gcaccgugga ggccugccug      360

ccccuggagc ugaccaagaa cggcagcugc cuggccagca gaaagaccag cuucaugaug      420

gcccugugcc ugagcagcau cuacgaggac cugaagaugu accaggugga guucaagacc      480

augaacgcca agcugcugau ggaccccaag agacagaucu uccuggacca gaacaugcug      540

gccgugaucg acgagcugau gcaggcccug aacuucaaca gcgagaccgu gccccagaag      600

agcagccugg aggagcccga cuucuacaag accaagauca agcugugcau ccugcugcac      660

gccuucagaa ucagagccgu gaccaucgac agagugauga gcuaccugaa cgccagcuag      720


<210>  722
<211>  762
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  IL12A

<400>  722
auguggcccc caggcagcgc cagccagccc ccacccagcc cugcugcugc caccggccug       60

cacccugcug cccggccugu gucccugcag ugccgccugu ccaugugccc agcccggagc      120

cugcugcugg uggccacccu ggugcugcug gaccaccuga gccuggccag gaaccugccu      180

guggccaccc cagaccccgg cauguucccc ugccugcacc acagccagaa ccugcugcgg      240

gcugugagca acaugcugca gaaggcccgg cagacccugg aguucuaccc cugcaccagc      300

gaggagauug accacgagga caucaccaag gacaagacca gcacagugga ggccugccug      360

ccccuggagc ugaccaagaa ugaaagcugc cugaacagcc gggagaccag cuucaucacc      420

aacggcagcu gccuggccag caggaagacc agcuucauga uggcccugug ccugagcagc      480

aucuaugagg accugaagau guaccaggug gaguucaaga ccaugaaugc caagcugcug      540

auggacccca agaggcagau cuuccuggac cagaacaugc uggccgugau ugaugagcug      600

augcaggccc ugaacuucaa cagcgagacc gugccccaga agagcagccu ggaggagcca      660

gacuucuaca agaccaagau caagcugugc auccugcugc acgccuuccg cauccgggcu      720

gugaccaucg acagagugau gagcuaccug aaugccagcu ag                         762


<210>  723
<211>  762
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  IL12A

<400>  723
auguggcccc caggcagcgc cagccagccc ccacccagcc cugcugcugc caccggccug       60

cacccugcug cccggccugu gucccugcag ugccgccugu ccaugugccc agcccggagc      120

cugcugcugg uggccacccu ggugcugcug gaccaccuga gccuggccag gaaccugccu      180

guggccaccc cagaccccgg cauguucccc ugccugcacc acagccagaa ccugcugcgg      240

gcugugagca acaugcugca gaaggcccgg cagacccugg aguucuaccc cugcaccagc      300

gaggagauug accacgagga caucaccaag gacaagacca gcacagugga ggccugccug      360

ccccuggagc ugaccaagaa ugaaagcugc cugaacagcc gggagaccag cuucaucacc      420

aacggcagcu gccuggccag caggaagacc agcuucauga uggcccugug ccugagcagc      480

aucuaugagg accugaagau guaccaggug gaguucaaga ccaugaaugc caagcugcug      540

auggacccca agaggcagau cuuccuggac cagaacaugc uggccgugau ugaugagcug      600

augcaggccc ugaacuucaa cagcgagacc gugccccaga agagcagccu ggaggagcca      660

gacuucuaca agaccaagau caagcugugc auccugcugc acgccuuccg cauccgggcu      720

gugaccaucg acagagugau gagcuaccug aaugccagcu ag                         762


<210>  724
<211>  762
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  IL12A

<400>  724
auguggcccc ccggcagcgc cagccagccc ccccccagcc ccgccgccgc caccggccug       60

caccccgccg ccagacccgu gagccugcag ugcagacuga gcaugugccc cgccagaagc      120

cugcugcugg uggccacccu ggugcugcug gaccaccuga gccuggccag aaaccugccc      180

guggccaccc ccgaccccgg cauguucccc ugccugcacc acagccagaa ccugcugaga      240

gccgugagca acaugcugca gaaggccaga cagacccugg aguucuaccc cugcaccagc      300

gaggagaucg accacgagga caucaccaag gacaagacca gcaccgugga ggccugccug      360

ccccuggagc ugaccaagaa cgagagcugc cugaacagca gagagaccag cuucaucacc      420

aacggcagcu gccuggccag cagaaagacc agcuucauga uggcccugug ccugagcagc      480

aucuacgagg accugaagau guaccaggug gaguucaaga ccaugaacgc caagcugcug      540

auggacccca agagacagau cuuccuggac cagaacaugc uggccgugau cgacgagcug      600

augcaggccc ugaacuucaa cagcgagacc gugccccaga agagcagccu ggaggagccc      660

gacuucuaca agaccaagau caagcugugc auccugcugc acgccuucag aaucagagcc      720

gugaccaucg acagagugau gagcuaccug aacgccagcu ag                         762


<210>  725
<211>  762
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  IL12A

<400>  725
auguggcccc ccggcagcgc cagccagccc ccccccagcc ccgccgccgc caccggccug       60

caccccgccg ccagacccgu gagccugcag ugcagacuga gcaugugccc cgccagaagc      120

cugcugcugg uggccacccu ggugcugcug gaccaccuga gccuggccag aaaccugccc      180

guggccaccc ccgaccccgg cauguucccc ugccugcacc acagccagaa ccugcugaga      240

gccgugagca acaugcugca gaaggccaga cagacccugg aguucuaccc cugcaccagc      300

gaggagaucg accacgagga caucaccaag gacaagacca gcaccgugga ggccugccug      360

ccccuggagc ugaccaagaa cgagagcugc cugaacagca gagagaccag cuucaucacc      420

aacggcagcu gccuggccag cagaaagacc agcuucauga uggcccugug ccugagcagc      480

aucuacgagg accugaagau guaccaggug gaguucaaga ccaugaacgc caagcugcug      540

auggacccca agagacagau cuuccuggac cagaacaugc uggccgugau cgacgagcug      600

augcaggccc ugaacuucaa cagcgagacc gugccccaga agagcagccu ggaggagccc      660

gacuucuaca agaccaagau caagcugugc auccugcugc acgccuucag aaucagagcc      720

gugaccaucg acagagugau gagcuaccug aacgccagcu ag                         762


<210>  726
<211>  2761
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  IL12 construct

<400>  726
gggcauacag uuguuccauc ccgacaugaa cucagccucc cgucugaccg ccccuuggcc       60

uuccuucuuc cucgaucugu ggaacccagg gaaucugccu agugcugucu ccaagcaccu      120

uggccaugau guaaacccag agaaauuagc aucuccaucu ccuuccuuau uccccaccca      180

aaagucauuu ccucuuaguu cauuaccugg gauuuugaug ucuauguucc cuccucguua      240

uugauacaca cacagagaga gacaaacaaa aaaggaacuu cuugaaauuc ccccagaagg      300

uuuugagagu uguuuucaau guugcaacaa gucaguuucu aguuuaaguu uccaucagaa      360

aggaguagag uauauaaguu ccaguaccag caacagcagc agaagaaaca acaucuguuu      420

cagggccauu ggacucuccg uccugcccag agcaagaugu gucaccagca guuggucauc      480

ucuugguuuu cccugguuuu ucuggcaucu ccccucgugg ccauauggga acugaagaaa      540

gauguuuaug ucguagaauu ggauugguau ccggaugccc cuggagaaau ggugguccuc      600

accugugaca ccccugaaga agaugguauc accuggaccu uggaccagag cagugagguc      660

uuaggcucug gcaaaacccu gaccauccaa gucaaagagu uuggagaugc uggccaguac      720

accugucaca aaggaggcga gguucuaagc cauucgcucc ugcugcuuca caaaaaggaa      780

gauggaauuu gguccacuga uauuuuaaag gaccagaaag aacccaaaaa uaagaccuuu      840

cuaagaugcg aggccaagaa uuauucugga cguuucaccu gcugguggcu gacgacaauc      900

aguacugauu ugacauucag ugucaaaagc agcagaggcu cuucugaccc ccaaggggug      960

acgugcggag cugcuacacu cucugcagag agagucagag gggacaacaa ggaguaugag     1020

uacucagugg agugccagga ggacagugcc ugcccagcug cugaggagag ucugcccauu     1080

gaggucaugg uggaugccgu ucacaagcuc aaguaugaaa acuacaccag cagcuucuuc     1140

aucagggaca ucaucaaacc ugacccaccc aagaacuugc agcugaagcc auuaaagaau     1200

ucucggcagg uggaggucag cugggaguac ccugacaccu ggaguacucc acauuccuac     1260

uucucccuga cauucugcgu ucagguccag ggcaagagca agagagaaaa gaaagauaga     1320

gucuucacgg acaagaccuc agccacgguc aucugccgca aaaaugccag cauuagcgug     1380

cgggcccagg accgcuacua uagcucaucu uggagcgaau gggcaucugu gcccugcagu     1440

uagguucuga uccaggauga aaauuuggag gaaaagugga agauauuaag caaaauguuu     1500

aaagacacaa cggaauagac ccaaaaagau aauuucuauc ugauuugcuu uaaaacguuu     1560

uuuuaggauc acaaugauau cuuugcugua uuuguauagu uagaugcuaa augcucauug     1620

aaacaaucag cuaauuuaug uauagauuuu ccagcucuca aguugccaug ggccuucaug     1680

cuauuuaaau auuuaaguaa uuuauguauu uauuaguaua uuacuguuau uuaacguuug     1740

ucugccagga uguauggaau guuucauacu cuuaugaccu gauccaucag gaucaguccc     1800

uauuaugcaa aaugugaauu uaauuuuauu uguacugaca acuuuucaag caaggcugca     1860

aguacaucag uuuuaugaca aucaggaaga augcaguguu cugauaccag ugccaucaua     1920

cacuugugau ggaugggaac gcaagagaua cuuacaugga aaccugacaa ugcaaaccug     1980

uugagaagau ccaggagaac aagaugcuag uucccauguc ugugaagacu uccuggagau     2040

gguguugaua aagcaauuua gggccacuua cacuucuaag caaguuuaau cuuuggaugc     2100

cugaauuuua aaagggcuag aaaaaaauga uugaccagcc ugggaaacau aacaagaccc     2160

cgucucuaca aaaaaaauuu aaaauuagcc aggcguggug gcucaugcuu guggucccag     2220

cuguucagga ggaugaggca ggaggaucuc uugagcccag gaggucaagg cuauggugag     2280

ccgugauugu gccacugcau accagccuag gugacagaau gagacccugu cucaaaaaaa     2340

aaaaugauug aaauuaaaau ucagcuuuag cuuccauggc aguccucacc cccaccucuc     2400

uaaaagacac aggaggauga cacagaaaca ccguaagugu cuggaaggca aaaagaucuu     2460

aagauucaag agagaggaca aguaguuaug gcuaaggaca ugaaauuguc agaauggcag     2520

guggcuucuu aacagcccug ugagaagcag acagaugcaa agaaaaucug gaaucccuuu     2580

cucauuagca ugaaugaacc ugauacacaa uuaugaccag aaaauauggc uccaugaagg     2640

ugcuacuuuu aaguaaugua ugugcgcucu guaaagugau uacauuuguu uccuguuugu     2700

uuauuuauuu auuuauuuuu gcauucugag gcugaacuaa uaaaaacucu ucuuuguaau     2760

c                                                                     2761


<210>  727
<211>  591
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  IL12A

<400>  727
auguguccag cgcgcagccu ccuccuugug gcuacccugg uccuccugga ccaccucagu       60

uuggccagaa accuccccgu ggccacucca gacccaggaa uguucccaug ccuucaccac      120

ucccaaaacc ugcugagggc cgucagcaac augcuccaga agaaugagag uugccuaaau      180

uccagagaga ccucuuucau aacuaauggg aguugccugg ccuccagaaa gaccucuuuu      240

augauggccc ugugccuuag uaguauuuau gaagacuuga agauguacca gguggaguuc      300

aagaccauga augcaaagcu ucugauggau ccuaagaggc agaucuuucu agaucaaaac      360

augcuggcag uuauugauga gcugaugcag gcccugaauu ucaacaguga gacugugcca      420

caaaaauccu cccuugaaga accggauuuu uauaaaacua aaaucaagcu cugcauacuu      480

cuucaugcuu ucagaauucg ggcagugacu auugauagag ugaugagcua ucugaaugcu      540

uccuaaaaag cgaggucccu ccaaaccguu gucauuuuua uaaaacuuug a               591


<210>  728
<211>  786
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  CD40LG

<400>  728
augaucgaga cauauaacca gaccucccca agauccgcag cuaccgggcu gccuaucagc       60

augaaaaucu uuauguacuu guuaacggug uuuuugauca cgcagaugau cggaagcgcc      120

cucuuugcag uguaucugca uagaaggcuu gacaaaauug aagaugagag aaaucugcac      180

gaagacuucg uguuuaugaa aaccauccaa cgguguaaca ccggggagcg gucucuuagc      240

cugcugaauu gcgaagagau uaagagccaa uuugaggguu uugugaaaga caucaugcug      300

aacaaagagg aaaccaagaa agaaaacucu uucgagaugc agaaagguga ccagaacccu      360

cagaucgccg cccacgugau cucugaggcc aguuccaaga cuacaucugu gcuccaaugg      420

gccgaaaaag gcuacuacac uauguccaau aacuugguga cccuagagaa cggaaagcaa      480

cugaccguga aacggcaggg acuguacuac auuuacgccc aggugacguu cugcuccaac      540

cgcgaagcca guucucaggc uccuuuuauc gccagucuuu gccucaaaag ccccgggcga      600

uucgaaagaa uccuguugag ggcagcaaac acacacucau ccgcuaaacc uugcgggcag      660

caaucgaucc aucuuggcgg agucuuugaa cugcagcccg gcgccucugu auucgugaac      720

gucacggacc caagccaggu gagccaugga acaggguuua caucauuugg acugcuaaag      780

cuguag                                                                 786


<210>  729
<211>  786
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  CD40LG

<400>  729
augaucgaga ccuacaacca gaccagcccc agaagcgccg ccaccggccu gcccaucagc       60

augaagaucu ucauguaccu gcugaccgug uuccugauca cccagaugau cggcagcgcc      120

cuguucgccg uguaccugca cagaagacug gacaagaucg aggacgagag aaaccugcac      180

gaggacuucg uguucaugaa gaccauccag agaugcaaca ccggcgagag aagccugagc      240

cugcugaacu gcgaggagau caagagccag uucgagggcu ucgugaagga caucaugcug      300

aacaaggagg agaccaagaa ggagaacagc uucgagaugc agaagggcga ccagaacccc      360

cagaucgccg cccacgugau cagcgaggcc agcagcaaga ccaccagcgu gcugcagugg      420

gccgagaagg gcuacuacac caugagcaac aaccugguga cccuggagaa cggcaagcag      480

cugaccguga agagacaggg ccuguacuac aucuacgccc aggugaccuu cugcagcaac      540

agagaggcca gcagccaggc ccccuucauc gccagccugu gccugaagag ccccggcaga      600

uucgagagaa uccugcugag agccgccaac acccacagca gcgccaagcc cugcggccag      660

cagagcaucc accugggcgg cguguucgag cugcagcccg gcgccagcgu guucgugaac      720

gugaccgacc ccagccaggu gagccacggc accggcuuca ccagcuucgg ccugcugaag      780

cuguag                                                                 786


<210>  730
<211>  786
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  CD40LG

<400>  730
augauugaga ccuacaacca gaccagcccc aggucugcug ccaccggccu gcccaucucc       60

augaagaucu ucauguaccu gcugacugug uuccugauca cccagaugau uggcagcgcc      120

cuguuugcug uguaccugca ccggcggcug gacaagauug aagaugaaag aaaccugcau      180

gaagauuuug uguucaugaa gaccauccag cgcugcaaca caggagagag gagccugagc      240

cugcugaacu gugaggagau caagagccag uuugagggcu uugugaagga caucaugcug      300

aacaaggagg agaccaagaa ggagaacagc uuugagaugc agaaggggga ccagaacccc      360

cagauugcug cccacgugau cagcgaggcc agcagcaaga ccaccucugu gcugcagugg      420

gccgagaagg gcuacuacac caugagcaac aaccugguga cccuggagaa uggcaagcag      480

cugacuguga agaggcaggg ccuguacuac aucuaugccc aggugaccuu cugcagcaac      540

cgggaggcca gcagccaggc ccccuucauc gccagccugu gccugaagag cccuggccgc      600

uuugagcgca uccugcugcg ggccgccaac acccacagca gcgccaagcc cuguggccag      660

cagagcaucc accugggcgg cguguuugag cugcagcccg gggccucugu guuugugaau      720

gugacagacc ccagccaggu gucccaugga acaggcuuca ccagcuuugg ccugcugaag      780

cuguag                                                                 786


<210>  731
<211>  786
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  CD40LG

<400>  731
augauugaga ccuacaacca gaccagcccc aggucugcug ccaccggccu gcccaucucc       60

augaagaucu ucauguaccu gcugacugug uuccugauca cccagaugau uggcagcgcc      120

cuguuugcug uguaccugca ccggcggcug gacaagauug aagaugaaag aaaccugcau      180

gaagauuuug uguucaugaa gaccauccag cgcugcaaca caggagagag gagccugagc      240

cugcugaacu gugaggagau caagagccag uuugagggcu uugugaagga caucaugcug      300

aacaaggagg agaccaagaa ggagaacagc uuugagaugc agaaggggga ccagaacccc      360

cagauugcug cccacgugau cagcgaggcc agcagcaaga ccaccucugu gcugcagugg      420

gccgagaagg gcuacuacac caugagcaac aaccugguga cccuggagaa uggcaagcag      480

cugacuguga agaggcaggg ccuguacuac aucuaugccc aggugaccuu cugcagcaac      540

cgggaggcca gcagccaggc ccccuucauc gccagccugu gccugaagag cccuggccgc      600

uuugagcgca uccugcugcg ggccgccaac acccacagca gcgccaagcc cuguggccag      660

cagagcaucc accugggcgg cguguuugag cugcagcccg gggccucugu guuugugaau      720

gugacagacc ccagccaggu gucccaugga acaggcuuca ccagcuuugg ccugcugaag      780

cuguag                                                                 786


<210>  732
<211>  786
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  CD40LG

<400>  732
augauugaga cguacaauca gacaagcccc cgaagcgcag cgaccggacu ucccauaagu       60

augaaaaucu uuauguaucu gcugaccgug uuucuuauca cccaaaugau aggcuccgcu      120

cuauuugccg uguaucucca ucgcaggcua gauaaaaucg aagaugagcg aaaccugcau      180

gaggacuuug uguucaugaa gacuauucag agguguaaca caggugagcg uucgcuuucu      240

cugcugaauu gugaagaaau caagucccag uuugagggcu ucgucaagga uauaaugcug      300

aacaaagagg agaccaagaa ggagaacagc uucgaaaugc aaaagggaga ccagaaccca      360

caaaucgcag cucacgucau aucagaggcc ucaucaaaaa caacaucggu ucugcaaugg      420

gcugaaaagg gcuauuauac caugucuaac aauuugguga ccuuggaaaa ugguaaacag      480

cucaccguga agcggcaggg ccuuuacuac auauacgcuc aggugacuuu uugcucuaau      540

cgggaagcca gcagucaggc accauucauu gcuucgcucu gccugaaaag cccagggaga      600

uuugaacgca uuuuacugcg cgcugcaaac acccacucua gcgcuaagcc auguggccaa      660

caguccauac acuuaggcgg aguauucgaa uuacagccug gcgcuagugu cuucguuaau      720

guaacagauc caucccaagu gagucacggc accggcuuca ccucuuuugg ucuguugaag      780

cuguag                                                                 786


<210>  733
<211>  786
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  CD40LG

<400>  733
augaucgaga ccuacaacca gaccagcccc cggagcgccg ccaccgguuu gccuaucucu       60

augaagaucu ucauguaccu ucucacuguu uuucugauua cccagaugau cgguucugcc      120

cuguucgcag uguacuugca ccgucgucug gauaaaaucg aagacgagcg gaaucuccau      180

gaggauuucg uguuuaugaa gacaauacag cgcugcaaca ccggcgaaag aagucucagc      240

uugcucaacu gcgaagagau caaaagccag uuugaggggu ucgugaaaga caucaugcuc      300

aauaaggagg agacaaaaaa ggagaacuca uucgaaaugc aaaagggaga ucagaaccca      360

cagaucgcgg cacaugugau uucugaagcc uccaguaaga cuaccucagu guugcagugg      420

gccgagaaag gauacuauac aaugagcaac aaucugguca cccuggagaa cggaaaacaa      480

uugacaguua agagacaggg ccuguacuac auuuaugccc aggugacguu cugcuccaau      540

cgugaagcua gcagccaggc cccguuuauc gcuucucuau gccugaaaag uccuggaagg      600

uuugagcgaa uucugcucag agcagcgaau acccacagca gugccaaacc cugugggcag      660

cagucuauuc accuuggcgg cguguucgag cugcagccgg gcgcauccgu guucgugaau      720

guaacagacc cgagucaagu gagucacggc accgguuuua ccaguuuugg gcuuuugaaa      780

uuguag                                                                 786


<210>  734
<211>  786
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  CD40LG

<400>  734
augauugaga cguacaauca gacaagcccc cgaagcgcag cgaccggacu ucccauaagu       60

augaaaaucu uuauguaucu gcugaccgug uuucuuauca cccaaaugau aggcuccgcu      120

cuauuugccg uguaucucca ucgcaggcua gauaaaaucg aagaugagcg aaaccugcau      180

gaggacuuug uguucaugaa gacuauucag agguguaaca caggugagcg uucgcuuucu      240

cugcugaauu gugaagaaau caagucccag uuugagggcu ucgucaagga uauaaugcug      300

aacaaagagg agaccaagaa ggagaacagc uucgaaaugc aaaagggaga ccagaaccca      360

caaaucgcag cucacgucau aucagaggcc ucaucaaaaa caacaucggu ucugcaaugg      420

gcugaaaagg gcuauuauac caugucuaac aauuugguga ccuuggaaaa ugguaaacag      480

cucaccguga agcggcaggg ccuuuacuac auauacgcuc aggugacuuu uugcucuaau      540

cgggaagcca gcagucaggc accauucauu gcuucgcucu gccugaaaag cccagggaga      600

uuugaacgca uuuuacugcg cgcugcaaac acccacucua gcgcuaagcc auguggccaa      660

caguccauac acuuaggcgg aguauucgaa uuacagccug gcgcuagugu cuucguuaau      720

guaacagauc caucccaagu gagucacggc accggcuuca ccucuuuugg ucuguugaag      780

cuguag                                                                 786


<210>  735
<211>  786
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  CD40LG

<400>  735
augaucgaga ccuacaacca gaccagcccc cggagcgccg ccaccgguuu gccuaucucu       60

augaagaucu ucauguaccu ucucacuguu uuucugauua cccagaugau cgguucugcc      120

cuguucgcag uguacuugca ccgucgucug gauaaaaucg aagacgagcg gaaucuccau      180

gaggauuucg uguuuaugaa gacaauacag cgcugcaaca ccggcgaaag aagucucagc      240

uugcucaacu gcgaagagau caaaagccag uuugaggggu ucgugaaaga caucaugcuc      300

aauaaggagg agacaaaaaa ggagaacuca uucgaaaugc aaaagggaga ucagaaccca      360

cagaucgcgg cacaugugau uucugaagcc uccaguaaga cuaccucagu guugcagugg      420

gccgagaaag gauacuauac aaugagcaac aaucugguca cccuggagaa cggaaaacaa      480

uugacaguua agagacaggg ccuguacuac auuuaugccc aggugacguu cugcuccaau      540

cgugaagcua gcagccaggc cccguuuauc gcuucucuau gccugaaaag uccuggaagg      600

uuugagcgaa uucugcucag agcagcgaau acccacagca gugccaaacc cugugggcag      660

cagucuauuc accuuggcgg cguguucgag cugcagccgg gcgcauccgu guucgugaau      720

guaacagacc cgagucaagu gagucacggc accgguuuua ccaguuuugg gcuuuugaaa      780

uuguag                                                                 786


<210>  736
<211>  786
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  CD40LG

<400>  736
augaucgaga ccuacaacca gaccagcccc cggagcgccg ccaccgguuu gccuaucucu       60

augaagaucu ucauguaccu ucucacuguu uuucugauua cccagaugau cgguucugcc      120

cuguucgcag uguacuugca ccgucgucug gauaaaaucg aagacgagcg gaaucuccau      180

gaggauuucg uguuuaugaa gacaauacag cgcugcaaca ccggcgaaag aagucucagc      240

uugcucaacu gcgaagagau caaaagccag uuugaggggu ucgugaaaga caucaugcuc      300

aauaaggagg agacaaaaaa ggagaacuca uucgaaaugc aaaagggaga ucagaaccca      360

cagaucgcgg cacaugugau uucugaagcc uccaguaaga cuaccucagu guugcagugg      420

gccgagaaag gauacuauac aaugagcaac aaucugguca cccuggagaa cggaaaacaa      480

uugacaguua agagacaggg ccuguacuac auuuaugccc aggugacguu cugcuccaau      540

cgugaagcua gcagccaggc cccguuuauc gcuucucuau gccugaaaag uccuggaagg      600

uuugagcgaa uucugcucag agcagcgaau acccacagca gugccaaacc cugugggcag      660

cagucuauuc accuuggcgg cguguucgag cugcagccgg gcgcauccgu guucgugaau      720

guaacagacc cgagucaagu gagucacggc accgguuuua ccaguuuugg gcuuuugaaa      780

uuguag                                                                 786


<210>  737
<211>  786
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  CD40LG

<400>  737
augaucgaga ccuacaacca gaccagcccc agaagcgccg ccaccggccu gcccaucagc       60

augaagaucu ucauguaccu gcugaccgug uuccugauca cccagaugau cggcagcgcc      120

cuguucgccg uguaccugca cagaagacug gacaagaucg aggacgagag aaaccugcac      180

gaggacuucg uguucaugaa gaccauccag agaugcaaca ccggcgagag aagccugagc      240

cugcugaacu gcgaggagau caagagccag uucgagggcu ucgugaagga caucaugcug      300

aacaaggagg agaccaagaa ggagaacagc uucgagaugc agaagggcga ccagaacccc      360

cagaucgccg cccacgugau cagcgaggcc agcagcaaga ccaccagcgu gcugcagugg      420

gccgagaagg gcuacuacac caugagcaac aaccugguga cccuggagaa cggcaagcag      480

cugaccguga agagacaggg ccuguacuac aucuacgccc aggugaccuu cugcagcaac      540

agagaggcca gcagccaggc ccccuucauc gccagccugu gccugaagag ccccggcaga      600

uucgagagaa uccugcugag agccgccaac acccacagca gcgccaagcc cugcggccag      660

cagagcaucc accugggcgg cguguucgag cugcagcccg gcgccagcgu guucgugaac      720

gugaccgacc ccagccaggu gagccacggc accggcuuca ccagcuucgg ccugcugaag      780

cuguag                                                                 786


<210>  738
<211>  786
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  CD40LG

<400>  738
augaucgaga cauauaacca gaccucccca agauccgcag cuaccgggcu gccuaucagc       60

augaaaaucu uuauguacuu guuaacggug uuuuugauca cgcagaugau cggaagcgcc      120

cucuuugcag uguaucugca uagaaggcuu gacaaaauug aagaugagag aaaucugcac      180

gaagacuucg uguuuaugaa aaccauccaa cgguguaaca ccggggagcg gucucuuagc      240

cugcugaauu gcgaagagau uaagagccaa uuugaggguu uugugaaaga caucaugcug      300

aacaaagagg aaaccaagaa agaaaacucu uucgagaugc agaaagguga ccagaacccu      360

cagaucgccg cccacgugau cucugaggcc aguuccaaga cuacaucugu gcuccaaugg      420

gccgaaaaag gcuacuacac uauguccaau aacuugguga cccuagagaa cggaaagcaa      480

cugaccguga aacggcaggg acuguacuac auuuacgccc aggugacguu cugcuccaac      540

cgcgaagcca guucucaggc uccuuuuauc gccagucuuu gccucaaaag ccccgggcga      600

uucgaaagaa uccuguugag ggcagcaaac acacacucau ccgcuaaacc uugcgggcag      660

caaucgaucc aucuuggcgg agucuuugaa cugcagcccg gcgccucugu auucgugaac      720

gucacggacc caagccaggu gagccaugga acaggguuua caucauuugg acugcuaaag      780

cuguag                                                                 786


<210>  739
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  signal peptide - HLA-A2-SP

<400>  739

Met Ala Val Met Ala Pro Arg Thr Leu Val Leu Leu Leu Ser Gly Ala 
1               5                   10                  15      


Leu Ala Leu Thr Gln Thr Trp Ala 
            20                  


<210>  740
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  signal peptide - HLA-A2-SP

<400>  740

Met Ala Val Met Ala Pro Arg Thr Leu Val Leu Leu Leu Ser Gly Ala 
1               5                   10                  15      


Leu Ala Leu Thr Gln Thr Trp Ala Gly 
            20                  25  


<210>  741
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  signal peptide - HsPLAT

<400>  741

Met Asp Ala Met Lys Arg Gly Leu Cys Cys Val Leu Leu Leu Cys Gly 
1               5                   10                  15      


Ala Val Phe Val Ser Pro Ser 
            20              


<210>  742
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  signal peptide - HsPLAT

<400>  742

Met Asp Ala Met Lys Arg Gly Leu Cys Cys Val Leu Leu Leu Cys Gly 
1               5                   10                  15      


Ala Val Phe Val Ser 
            20      


<210>  743
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  signal peptide - HsPLAT

<400>  743

Met Asp Ala Met Lys Arg Gly Leu Cys Cys Val Leu Leu Leu Cys Gly 
1               5                   10                  15      


Ala Val Phe Val Ser Pro 
            20          


<210>  744
<211>  27
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  signal peptide - HsEPO

<400>  744

Met Gly Val His Glu Cys Pro Ala Trp Leu Trp Leu Leu Leu Ser Leu 
1               5                   10                  15      


Leu Ser Leu Pro Leu Gly Leu Pro Val Leu Gly 
            20                  25          


<210>  745
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  signal peptide - HsALB

<400>  745

Met Lys Trp Val Thr Phe Ile Ser Leu Leu Phe Leu Phe Ser Ser Ala 
1               5                   10                  15      


Tyr Ser 
        


<210>  746
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  signal peptide - IgE

<400>  746

Met Asp Trp Thr Trp Ile Leu Phe Leu Val Ala Ala Ala Thr Arg Val 
1               5                   10                  15      


His Ser 
        


<210>  747
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  signal peptide - HsCD5

<400>  747

Met Pro Met Gly Ser Leu Gln Pro Leu Ala Thr Leu Tyr Leu Leu Gly 
1               5                   10                  15      


Met Leu Val Ala Ser Cys Leu Gly 
            20                  


<210>  748
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  signal peptide - HsIL2

<400>  748

Met Tyr Arg Met Gln Leu Leu Ser Cys Ile Ala Leu Ser Leu Ala Leu 
1               5                   10                  15      


Val Thr Asn Ser 
            20  


<210>  749
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  signal peptide - HsCTRB2

<400>  749

Met Ala Phe Leu Trp Leu Leu Ser Cys Trp Ala Leu Leu Gly Thr Thr 
1               5                   10                  15      


Phe Gly 
        


<210>  750
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  signal peptide - immunoglobulin (IgG heavy chain)

<400>  750

Met Glu Phe Gly Leu Ser Trp Val Phe Leu Val Ala Leu Phe Arg Gly 
1               5                   10                  15      


Val Gln Cys 
            


<210>  751
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  signal peptide - human immunoglobulin heavy chain

<400>  751

Met Asp Trp Thr Trp Arg Val Phe Cys Leu Leu Ala Val Thr Pro Gly 
1               5                   10                  15      


Ala His Pro 
            


<210>  752
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  signal peptide - human immunoglobulin light chain

<400>  752

Met Ala Trp Ser Pro Leu Phe Leu Thr Leu Ile Thr His Cys Ala Gly 
1               5                   10                  15      


Ser Trp Ala 
            


<210>  753
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  signal peptide - GpLuc

<400>  753

Met Gly Val Lys Val Leu Phe Ala Leu Ile Cys Ile Ala Val Ala Glu 
1               5                   10                  15      


Ala 
    


<210>  754
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  signal peptide - MmIgkappa

<400>  754

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Asp 
            20      


<210>  755
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  signal peptide - NrChit1

<400>  755

Met Lys Thr His Tyr Ser Ser Ala Ile Leu Pro Ile Leu Thr Leu Phe 
1               5                   10                  15      


Val Phe Leu Ser Ile Asn Pro Ser His Gly 
            20                  25      


<210>  756
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  signal peptide - ClLp1.1

<400>  756

Met Gly Met Arg Met Met Phe Ile Met Phe Met Leu Val Val Leu Ala 
1               5                   10                  15      


Thr Thr Val Val Ser 
            20      


<210>  757
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  signal peptide - NgNep1

<400>  757

Met Ala Ser Ser Leu Tyr Ser Phe Leu Leu Ala Leu Ser Ile Val Tyr 
1               5                   10                  15      


Ile Phe Val Ala Pro Thr His Ser 
            20                  


<210>  758
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  signal peptide - HsAzu1

<400>  758

Met Thr Arg Leu Thr Val Leu Ala Leu Leu Ala Gly Leu Leu Ala Ser 
1               5                   10                  15      


Ser Arg Ala 
            


<210>  759
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  signal peptide - HsCD33

<400>  759

Met Pro Leu Leu Leu Leu Leu Pro Leu Leu Trp Ala Gly Ala Leu Ala 
1               5                   10                  15      


<210>  760
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  signal peptide - VcCtxB

<400>  760

Met Ile Lys Leu Lys Phe Gly Val Phe Phe Thr Val Leu Leu Ser Ser 
1               5                   10                  15      


Ala Tyr Ala 
            


<210>  761
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  signal peptide - HsCST4

<400>  761

Met Ala Arg Pro Leu Cys Thr Leu Leu Leu Leu Met Ala Thr Leu Ala 
1               5                   10                  15      


Gly Ala Leu Ala 
            20  


<210>  762
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  signal peptide - HsIns-iso1

<400>  762

Met Ala Leu Trp Met Arg Leu Leu Pro Leu Leu Ala Leu Leu Ala Leu 
1               5                   10                  15      


Trp Gly Pro Asp Pro Ala Ala Ala 
            20                  


<210>  763
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  signal peptide - HsSPARC

<400>  763

Met Arg Ala Trp Ile Phe Phe Leu Leu Cys Leu Ala Gly Arg Ala Leu 
1               5                   10                  15      


Ala 
    


<210>  764
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  signal peptide - H1N1(Netherlands2009)-HA

<400>  764

Met Lys Ala Ile Leu Val Val Leu Leu Tyr Thr Phe Ala Thr Ala Asn 
1               5                   10                  15      


Ala 
    


<210>  765
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  signal peptide - YFV

<400>  765

Met Arg Gly Leu Ser Ser Arg Lys Arg Arg Ser His Asp Val Leu Thr 
1               5                   10                  15      


Val Gln Phe Leu Ile Leu Gly Met Leu Leu Met Thr Gly Gly 
            20                  25                  30  


<210>  766
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  signal peptide - MHCII

<400>  766

Met Ala Ile Ser Gly Val Pro Val Leu Gly Phe Phe Ile Ile Ala Val 
1               5                   10                  15      


Leu Met Ser Ala Gln Glu Ser Trp Ala 
            20                  25  


<210>  767
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  signal peptide - JEV

<400>  767

Met Gly Lys Arg Ser Ala Gly Ser Ile Met Trp Leu Ala Ser Leu Ala 
1               5                   10                  15      


Val Val Ile Ala Cys Ala Gly Ala 
            20                  


<210>  768
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  signal peptide - JEV

<400>  768

Met Gly Arg Lys Gln Asn Lys Arg Gly Gly Asn Glu Gly Ser Ile Met 
1               5                   10                  15      


Trp Leu Ala Ser Leu Ala Val Val Ile Ala Cys Ala Gly Ala 
            20                  25                  30  


<210>  769
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  signal peptide - JEV

<400>  769

Met Asn Glu Gly Ser Ile Met Trp Leu Ala Ser Leu Ala Val Val Ile 
1               5                   10                  15      


Ala Cys Ala Gly Ala 
            20      


<210>  770
<211>  72
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  signal peptide - HLA-A2-SP

<400>  770
auggccguca uggcgccccg aacccucguc cugcuacucu cgggggcucu ggcccugacc       60

cagaccuggg cg                                                           72


<210>  771
<211>  75
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  signal peptide - HLA-A2-SP

<400>  771
auggccguca uggcgccccg aacccucguc cugcuacucu cgggggcucu ggcccugacc       60

cagaccuggg cgggc                                                        75


<210>  772
<211>  69
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  signal peptide - HsPLAT

<400>  772
auggaugcaa ugaagagagg gcucugcugu gugcugcugc uguguggagc agucuucguu       60

ucgcccagc                                                               69


<210>  773
<211>  63
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  signal peptide - HsPLAT

<400>  773
auggaugcaa ugaagagagg gcucugcugu gugcugcugc uguguggagc agucuucguu       60

ucg                                                                     63


<210>  774
<211>  66
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  signal peptide - HsPLAT

<400>  774
auggaugcaa ugaagagagg gcucugcugu gugcugcugc uguguggagc agucuucguu       60

ucgccc                                                                  66


<210>  775
<211>  81
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  signal peptide - HsEPO

<400>  775
augggggugc acgaaugucc ugccuggcug uggcuucucc ugucccugcu gucgcucccu       60

cugggccucc caguccuggg c                                                 81


<210>  776
<211>  54
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  signal peptide - HsALB

<400>  776
augaaguggg uaaccuuuau uucccuucuu uuucucuuua gcucggcuua uucc             54


<210>  777
<211>  54
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  signal peptide - IgE

<400>  777
auggacugga ccuggauccu guuccucgug gccgccgcga cccgcgucca cagc             54


<210>  778
<211>  72
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  signal peptide - HsCD5

<400>  778
augcccaugg ggucucugca accgcuggcc accuuguacc ugcuggggau gcuggucgcu       60

uccugccucg ga                                                           72


<210>  779
<211>  60
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  signal peptide - HsIL2

<400>  779
auguacagga ugcaacuccu gucuugcauu gcacuaaguc uugcacuugu cacaaacagu       60


<210>  780
<211>  54
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  signal peptide - HsCTRB2

<400>  780
auggcuuucc ucuggcuccu cuccugcugg gcccuccugg guaccaccuu cggc             54


<210>  781
<211>  57
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  signal peptide - immunoglobulin (IgG heavy chain)

<400>  781
auggaguuug ggcugagcug gguuuuccuc guugcucuuu uuagaggugu ccagugu          57


<210>  782
<211>  57
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  signal peptide - human immunoglobulin heavy chain

<400>  782
auggacugga ccuggagggu cuucuguuug cuggcuguaa cuccaggcgc ccacccc          57


<210>  783
<211>  57
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  signal peptide - human immunoglobulin light chain

<400>  783
auggccuggu ccccucucuu ccucacccuc aucacucacu gugcaggguc cugggcc          57


<210>  784
<211>  51
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  signal peptide - GpLuc

<400>  784
augggaguga aaguucuuuu ugcccuuauu uguauugcug uggccgaggc c                51


<210>  785
<211>  63
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  signal peptide - MmIgkappa

<400>  785
auggagacag acacacuccu gcuaugggug cugcugcucu ggguuccagg uuccacaggu       60

gac                                                                     63


<210>  786
<211>  78
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  signal peptide - NrChit1

<400>  786
augaagaccc auuauucauc agcaauucuc ccgauccuca cccucuucgu cuuucucucg       60

aucaauccau cccauggc                                                     78


<210>  787
<211>  63
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  signal peptide - ClLp1.1

<400>  787
augggcaugc ggaugauguu caucauguuu augcugguug ucuuggcaac cacugucguu       60

ucc                                                                     63


<210>  788
<211>  72
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  signal peptide - NgNep1

<400>  788
auggccucgu cgcuguauuc uuucuuacuc gcauuaucga uaguuuacau cuuuguugcc       60

ccaacacauu cu                                                           72


<210>  789
<211>  57
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  signal peptide - HsAzu1

<400>  789
augacccggc ugacaguccu ggcccugcug gcuggucugc uggcguccuc gagggcc          57


<210>  790
<211>  48
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  signal peptide - HsCD33

<400>  790
augccgcugc ugcuacugcu gccccugcug ugggcagggg cccuggcu                    48


<210>  791
<211>  57
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  signal peptide - VcCtxB

<400>  791
augauuaaau uaaaauuugg uguuuuuuuu acaguuuuac uaucuucagc auaugca          57


<210>  792
<211>  60
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  signal peptide - HsCST4

<400>  792
auggcccggc cucuguguac ccugcuacuc cugauggcua cccuggcugg ggcucuggcc       60


<210>  793
<211>  72
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  signal peptide - HsIns-iso1

<400>  793
auggcccugu ggaugcgccu ccugccccug cuggcgcugc uggcccucug gggaccugac       60

ccagccgcag cc                                                           72


<210>  794
<211>  51
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  signal peptide - HsSPARC

<400>  794
augagggccu ggaucuucuu ucuccuuugc cuggccggga gggcucuggc a                51


<210>  795
<211>  51
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  signal peptide - H1N1(Netherlands2009)-HA

<400>  795
augaaggcaa uacuaguagu ucugcuauau acauuugcaa ccgcaaaugc a                51


<210>  796
<211>  90
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  signal peptide - YFV

<400>  796
augagaggau uguccucaag gaaacgccgu ucccaugaug uucugacugu gcaauuccua       60

auuuugggaa ugcuguugau gacgggugga                                        90


<210>  797
<211>  75
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  signal peptide - MHCII

<400>  797
auggccauaa guggaguccc ugugcuagga uuuuucauca uagcugugcu gaugagcgcu       60

caggaaucau gggcu                                                        75


<210>  798
<211>  72
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  signal peptide - JEV

<400>  798
auggguaaac ggagcgcugg cucaaucaug uggcucgcga gcuuggcagu ugucauagcu       60

ugugcaggag cc                                                           72


<210>  799
<211>  90
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  signal peptide - JEV

<400>  799
augggcagaa agcaaaacaa aagaggagga aaugaaggcu caaucaugug gcucgcgagc       60

uuggcaguug ucauagcuug ugcaggagcc                                        90


<210>  800
<211>  63
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  signal peptide - JEV

<400>  800
augaaugaag gcucaaucau guggcucgcg agcuuggcag uugucauagc uugugcagga       60

gcc                                                                     63


<210>  801
<211>  72
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  signal peptide - HLA-A2-SP

<400>  801
auggccguga uggccccgcg gacccugguc cuccugcuga gcggcgcgcu cgcccugacc       60

cagacguggg cc                                                           72


<210>  802
<211>  75
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  signal peptide - HLA-A2-SP

<400>  802
auggccguga uggccccgcg gacccugguc cuccugcuga gcggcgcgcu cgcccugacc       60

cagacguggg ccggg                                                        75


<210>  803
<211>  69
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  signal peptide - HsPLAT

<400>  803
auggacgcca ugaagcgcgg ccugugcugc gugcuccugc ugugcggggc cgucuucgug       60

agccccucc                                                               69


<210>  804
<211>  63
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  signal peptide - HsPLAT

<400>  804
auggacgcca ugaagcgcgg ccugugcugc gugcuccugc ugugcggggc cgucuucgug       60

agc                                                                     63


<210>  805
<211>  66
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  signal peptide - HsPLAT

<400>  805
auggacgcca ugaagcgcgg ccugugcugc gugcuccugc ugugcggggc cgucuucgug       60

agcccc                                                                  66


<210>  806
<211>  81
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  signal peptide - HsEPO

<400>  806
augggcgugc acgagugccc cgccuggcug uggcuccugc ugagccuccu gucccugccg       60

cucgggcugc ccguccuggg c                                                 81


<210>  807
<211>  54
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  signal peptide - HsALB

<400>  807
augaaguggg ugaccuucau cagccugcuc uuccuguucu ccagcgccua cucc             54


<210>  808
<211>  54
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  signal peptide - IgE

<400>  808
auggacugga ccuggauccu guuccucgug gccgccgcga cccgcgucca cagc             54


<210>  809
<211>  72
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  signal peptide - HsCD5

<400>  809
augcccaugg gcagccugca gccgcucgcc acccuguacc ugcucgggau gcugguggcc       60

uccugccugg gc                                                           72


<210>  810
<211>  60
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  signal peptide - HsIL2

<400>  810
auguaccgga ugcagcugcu cagcugcauc gcccugucgc uggcgcucgu gaccaacagc       60


<210>  811
<211>  54
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  signal peptide - HsCTRB2

<400>  811
auggccuucc uguggcuccu gagcugcugg gcccugcucg gcaccaccuu cggg             54


<210>  812
<211>  57
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  signal peptide - immunoglobulin (IgG heavy chain)

<400>  812
auggaguucg gccugagcug gguguuccuc gucgcccugu uccgcggggu gcagugc          57


<210>  813
<211>  57
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  signal peptide - human immunoglobulin heavy chain

<400>  813
auggacugga ccuggcgcgu guucugccug cucgccguca cccccggcgc ccacccg          57


<210>  814
<211>  57
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  signal peptide - human immunoglobulin light chain

<400>  814
auggccugga gcccccuguu ccucacccug aucacccacu gcgccggcuc cugggcg          57


<210>  815
<211>  51
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  signal peptide - GpLuc

<400>  815
augggcguga agguccuguu cgcccucauc ugcaucgccg uggcggaggc c                51


<210>  816
<211>  63
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  signal peptide - MmIgkappa

<400>  816
auggagaccg acacccugcu ccugugggug cugcuccugu ggguccccgg cagcacgggg       60

gac                                                                     63


<210>  817
<211>  78
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  signal peptide - NrChit1

<400>  817
augaagaccc acuacagcuc cgccauccug cccauccuca cccuguucgu guuccugagc       60

aucaacccgu cccacggc                                                     78


<210>  818
<211>  63
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  signal peptide - ClLp1.1

<400>  818
augggcaugc gcaugauguu caucauguuc augcuggugg uccucgccac caccguggug       60

agc                                                                     63


<210>  819
<211>  72
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  signal peptide - NgNep1

<400>  819
auggccagcu cccuguacag cuuccuccug gcccugucca ucguguacau cuucgucgcg       60

cccacccaca gc                                                           72


<210>  820
<211>  57
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  signal peptide - HsAzu1

<400>  820
augacccgcc ugaccgugcu cgcccugcug gccggccucc uggcgagcuc ccgggcc          57


<210>  821
<211>  48
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  signal peptide - HsCD33

<400>  821
augccccugc uccugcugcu cccgcugcug ugggccggcg cccucgcg                    48


<210>  822
<211>  57
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  signal peptide - VcCtxB

<400>  822
augaucaagc ugaaguucgg cguguucuuc accguccucc ugagcuccgc cuacgcc          57


<210>  823
<211>  60
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  signal peptide - HsCST4

<400>  823
auggcccgcc cccugugcac ccuccugcug cucauggcca cccuggcggg cgcccuggcc       60


<210>  824
<211>  72
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  signal peptide - HsIns-iso1

<400>  824
auggcccugu ggaugcgccu ccugccccug cucgcccugc uggcgcucug gggcccggac       60

cccgccgccg cc                                                           72


<210>  825
<211>  51
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  signal peptide - HsSPARC

<400>  825
augcgcgccu ggaucuucuu ccugcucugc cuggccggcc gggcccuggc c                51


<210>  826
<211>  51
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  signal peptide - H1N1(Netherlands2009)-HA

<400>  826
augaaggcca uccugguggu ccuccuguac accuucgcca ccgcgaacgc c                51


<210>  827
<211>  90
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  signal peptide - YFV

<400>  827
augcggggcc ugagcucccg caagcggcgc agccacgacg ugcucaccgu ccaguuccug       60

auccugggga ugcuccugau gaccggcggg                                        90


<210>  828
<211>  75
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  signal peptide - MHCII

<400>  828
auggccauca gcggcgugcc cguccugggg uucuucauca ucgccgugcu cauguccgcg       60

caggagagcu gggcc                                                        75


<210>  829
<211>  72
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  signal peptide - JEV

<400>  829
augggcaagc gcagcgccgg guccaucaug uggcuggcca gccucgcggu ggucaucgcc       60

ugcgccggcg cc                                                           72


<210>  830
<211>  90
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  signal peptide - JEV

<400>  830
augggccgga agcagaacaa gcgcgggggc aacgagggga gcaucaugug gcuggccucc       60

cucgccgugg ucaucgcgug cgccggcgcc                                        90


<210>  831
<211>  63
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  signal peptide - JEV

<400>  831
augaacgagg gcagcaucau guggcuggcc ucccucgccg uggucaucgc gugcgccggg       60

gcc                                                                     63


<210>  832
<211>  467
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ipilimumab backbone Rituximab HC with signale peptide

<400>  832

Met Glu Leu Gly Leu Ser Trp Ile Phe Leu Leu Ala Ile Leu Lys Gly 
1               5                   10                  15      


Val Gln Cys Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln 
            20                  25                  30          


Pro Gly Arg Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe 
        35                  40                  45              


Ser Ser Tyr Thr Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu 
    50                  55                  60                  


Glu Trp Val Thr Phe Ile Ser Tyr Asp Gly Asn Asn Lys Tyr Tyr Ala 
65                  70                  75                  80  


Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn 
                85                  90                  95      


Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Ile 
            100                 105                 110         


Tyr Tyr Cys Ala Arg Thr Gly Trp Leu Gly Pro Phe Asp Tyr Trp Gly 
        115                 120                 125             


Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser 
    130                 135                 140                 


Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala 
145                 150                 155                 160 


Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val 
                165                 170                 175     


Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala 
            180                 185                 190         


Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val 
        195                 200                 205             


Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His 
    210                 215                 220                 


Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Pro Lys Ser Cys 
225                 230                 235                 240 


Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
                245                 250                 255     


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
            260                 265                 270         


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
        275                 280                 285             


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
    290                 295                 300                 


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
305                 310                 315                 320 


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
                325                 330                 335     


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
            340                 345                 350         


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
        355                 360                 365             


Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser 
    370                 375                 380                 


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
385                 390                 395                 400 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
                405                 410                 415     


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
            420                 425                 430         


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
        435                 440                 445             


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
    450                 455                 460                 


Pro Gly Lys 
465         


<210>  833
<211>  448
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ipilimumab backbone Rituximab HC without signale peptide

<400>  833

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Thr Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Thr Phe Ile Ser Tyr Asp Gly Asn Asn Lys Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Ile Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Thr Gly Trp Leu Gly Pro Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro 
        115                 120                 125             


Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly 
    130                 135                 140                 


Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn 
145                 150                 155                 160 


Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln 
                165                 170                 175     


Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser 
            180                 185                 190         


Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser 
        195                 200                 205             


Asn Thr Lys Val Asp Lys Arg Val Glu Pro Lys Ser Cys Asp Lys Thr 
    210                 215                 220                 


His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser 
225                 230                 235                 240 


Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg 
                245                 250                 255     


Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro 
            260                 265                 270         


Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala 
        275                 280                 285             


Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val 
    290                 295                 300                 


Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr 
305                 310                 315                 320 


Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr 
                325                 330                 335     


Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu 
            340                 345                 350         


Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys 
        355                 360                 365             


Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser 
    370                 375                 380                 


Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp 
385                 390                 395                 400 


Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser 
                405                 410                 415     


Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala 
            420                 425                 430         


Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440                 445             


<210>  834
<211>  235
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ipilimumab backbone Rituximab LC with signale peptide

<400>  834

Met Glu Thr Pro Ala Gln Leu Leu Phe Leu Leu Leu Leu Trp Leu Pro 
1               5                   10                  15      


Asp Thr Thr Gly Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser 
            20                  25                  30          


Leu Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser 
        35                  40                  45              


Val Gly Ser Ser Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala 
    50                  55                  60                  


Pro Arg Leu Leu Ile Tyr Gly Ala Phe Ser Arg Ala Thr Gly Ile Pro 
65                  70                  75                  80  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile 
                85                  90                  95      


Ser Arg Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr 
            100                 105                 110         


Gly Ser Ser Pro Trp Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
        115                 120                 125             


Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
    130                 135                 140                 


Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
145                 150                 155                 160 


Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
                165                 170                 175     


Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
            180                 185                 190         


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
        195                 200                 205             


Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
    210                 215                 220                 


Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230                 235 


<210>  835
<211>  386
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ovalbumin Ova

<400>  835

Met Gly Ser Ile Gly Ala Ala Ser Met Glu Phe Cys Phe Asp Val Phe 
1               5                   10                  15      


Lys Glu Leu Lys Val His His Ala Asn Glu Asn Ile Phe Tyr Cys Pro 
            20                  25                  30          


Ile Ala Ile Met Ser Ala Leu Ala Met Val Tyr Leu Gly Ala Lys Asp 
        35                  40                  45              


Ser Thr Arg Thr Gln Ile Asn Lys Val Val Arg Phe Asp Lys Leu Pro 
    50                  55                  60                  


Gly Phe Gly Asp Ser Ile Glu Ala Gln Cys Gly Thr Ser Val Asn Val 
65                  70                  75                  80  


His Ser Ser Leu Arg Asp Ile Leu Asn Gln Ile Thr Lys Pro Asn Asp 
                85                  90                  95      


Val Tyr Ser Phe Ser Leu Ala Ser Arg Leu Tyr Ala Glu Glu Arg Tyr 
            100                 105                 110         


Pro Ile Leu Pro Glu Tyr Leu Gln Cys Val Lys Glu Leu Tyr Arg Gly 
        115                 120                 125             


Gly Leu Glu Pro Ile Asn Phe Gln Thr Ala Ala Asp Gln Ala Arg Glu 
    130                 135                 140                 


Leu Ile Asn Ser Trp Val Glu Ser Gln Thr Asn Gly Ile Ile Arg Asn 
145                 150                 155                 160 


Val Leu Gln Pro Ser Ser Val Asp Ser Gln Thr Ala Met Val Leu Val 
                165                 170                 175     


Asn Ala Ile Val Phe Lys Gly Leu Trp Glu Lys Ala Phe Lys Asp Glu 
            180                 185                 190         


Asp Thr Gln Ala Met Pro Phe Arg Val Thr Glu Gln Glu Ser Lys Pro 
        195                 200                 205             


Val Gln Met Met Tyr Gln Ile Gly Leu Phe Arg Val Ala Ser Met Ala 
    210                 215                 220                 


Ser Glu Lys Met Lys Ile Leu Glu Leu Pro Phe Ala Ser Gly Thr Met 
225                 230                 235                 240 


Ser Met Leu Val Leu Leu Pro Asp Glu Val Ser Gly Leu Glu Gln Leu 
                245                 250                 255     


Glu Ser Ile Ile Asn Phe Glu Lys Leu Thr Glu Trp Thr Ser Ser Asn 
            260                 265                 270         


Val Met Glu Glu Arg Lys Ile Lys Val Tyr Leu Pro Arg Met Lys Met 
        275                 280                 285             


Glu Glu Lys Tyr Asn Leu Thr Ser Val Leu Met Ala Met Gly Ile Thr 
    290                 295                 300                 


Asp Val Phe Ser Ser Ser Ala Asn Leu Ser Gly Ile Ser Ser Ala Glu 
305                 310                 315                 320 


Ser Leu Lys Ile Ser Gln Ala Val His Ala Ala His Ala Glu Ile Asn 
                325                 330                 335     


Glu Ala Gly Arg Glu Val Val Gly Ser Ala Glu Ala Gly Val Asp Ala 
            340                 345                 350         


Ala Ser Val Ser Glu Glu Phe Arg Ala Asp His Pro Phe Leu Phe Cys 
        355                 360                 365             


Ile Lys His Ile Ala Thr Asn Ala Val Leu Phe Phe Gly Arg Cys Val 
    370                 375                 380                 


Ser Pro 
385     


<210>  836
<211>  1543
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  OVA RNActive

<400>  836
ggggcgcugc cuacggaggu ggcagccauc uccuucucgg caucaagcuu accaugggca       60

gcaucggggc cgcgucgaug gaguucugcu ucgacguguu caaggagcug aagguccacc      120

acgccaacga gaacaucuuc uacugcccga ucgccaucau gagcgcgcuc gccauggugu      180

accugggcgc caaggacagc acccggacgc agaucaacaa ggugguccgc uucgacaagc      240

ugcccggcuu cggggacucg aucgaggcgc agugcggcac cagcgugaac gugcacagcu      300

cgcuccggga cauccugaac cagaucacca agccgaacga cgucuacagc uucagccugg      360

ccucgcggcu cuacgccgag gagcgcuacc cgauccugcc cgaguaccug cagugcguga      420

aggagcucua ccggggcggg cuggagccga ucaacuucca gacggcggcc gaccaggccc      480

gggagcugau caacagcugg guggagagcc agaccaacgg caucauccgc aacguccucc      540

agccgucgag cguggacagc cagaccgcga uggugcuggu caacgccauc guguucaagg      600

gccuguggga gaagacguuc aaggacgagg acacccaggc caugcccuuc cgggugaccg      660

agcaggaguc gaagccgguc cagaugaugu accagaucgg gcucuuccgg guggcgagca      720

uggccagcga gaagaugaag auccuggagc ugccguucgc cucgggcacg augagcaugc      780

ucgugcugcu gcccgacgag gucagcggcc ucgagcagcu ggagucgauc aucaacuucg      840

agaagcugac cgaguggacc agcagcaacg ugauggagga gcgcaagauc aagguguacc      900

ucccgcggau gaagauggag gagaaguaca accugacguc gguccugaug gcgaugggga      960

ucaccgacgu guucagcagc ucggccaacc ucagcggcau cagcucggcc gagagccuga     1020

agaucagcca ggcggugcac gccgcccacg cggagaucaa cgaggccggc cgggaggucg     1080

uggggucggc cgaggcgggc guggacgccg ccagcgucag cgaggaguuc cgcgcggacc     1140

acccguuccu guucugcauc aagcacaucg ccaccaacgc cgugcucuuc uucggccggu     1200

gcgugucgcc cugaccacua gugcaucaca uuuaaaagca ucucagccua ccaugagaau     1260

aagagaaaga aaaugaagau caauagcuua uucaucucuu uuucuuuuuc guugguguaa     1320

agccaacacc cugucuaaaa aacauaaauu ucuuuaauca uuuugccucu uuucucugug     1380

cuucaauuaa uaaaaaaugg aaagaaccua gaucuaaaaa aaaaaaaaaa aaaaaaaaaa     1440

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaau gcaucccccc cccccccccc     1500

cccccccccc cccccaaagg cucuuuucag agccaccaga auu                       1543


<210>  837
<211>  1857
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  ppLuc

<400>  837
gggagaaagc uugaggaugg aggacgccaa gaacaucaag aagggcccgg cgcccuucua       60

cccgcuggag gacgggaccg ccggcgagca gcuccacaag gccaugaagc gguacgcccu      120

ggugccgggc acgaucgccu ucaccgacgc ccacaucgag gucgacauca ccuacgcgga      180

guacuucgag augagcgugc gccuggccga ggccaugaag cgguacggcc ugaacaccaa      240

ccaccggauc guggugugcu cggagaacag ccugcaguuc uucaugccgg ugcugggcgc      300

ccucuucauc ggcguggccg ucgccccggc gaacgacauc uacaacgagc gggagcugcu      360

gaacagcaug gggaucagcc agccgaccgu gguguucgug agcaagaagg gccugcagaa      420

gauccugaac gugcagaaga agcugcccau cauccagaag aucaucauca uggacagcaa      480

gaccgacuac cagggcuucc agucgaugua cacguucgug accagccacc ucccgccggg      540

cuucaacgag uacgacuucg ucccggagag cuucgaccgg gacaagacca ucgcccugau      600

caugaacagc agcggcagca ccggccugcc gaagggggug gcccugccgc accggaccgc      660

cugcgugcgc uucucgcacg cccgggaccc caucuucggc aaccagauca ucccggacac      720

cgccauccug agcguggugc cguuccacca cggcuucggc auguucacga cccugggcua      780

ccucaucugc ggcuuccggg ugguccugau guaccgguuc gaggaggagc uguuccugcg      840

gagccugcag gacuacaaga uccagagcgc gcugcucgug ccgacccugu ucagcuucuu      900

cgccaagagc acccugaucg acaaguacga ccugucgaac cugcacgaga ucgccagcgg      960

gggcgccccg cugagcaagg aggugggcga ggccguggcc aagcgguucc accucccggg     1020

cauccgccag ggcuacggcc ugaccgagac cacgagcgcg auccugauca cccccgaggg     1080

ggacgacaag ccgggcgccg ugggcaaggu ggucccguuc uucgaggcca agguggugga     1140

ccuggacacc ggcaagaccc ugggcgugaa ccagcggggc gagcugugcg ugcgggggcc     1200

gaugaucaug agcggcuacg ugaacaaccc ggaggccacc aacgcccuca ucgacaagga     1260

cggcuggcug cacagcggcg acaucgccua cugggacgag gacgagcacu ucuucaucgu     1320

cgaccggcug aagucgcuga ucaaguacaa gggcuaccag guggcgccgg ccgagcugga     1380

gagcauccug cuccagcacc ccaacaucuu cgacgccggc guggccgggc ugccggacga     1440

cgacgccggc gagcugccgg ccgcgguggu ggugcuggag cacggcaaga ccaugacgga     1500

gaaggagauc gucgacuacg uggccagcca ggugaccacc gccaagaagc ugcggggcgg     1560

cgugguguuc guggacgagg ucccgaaggg ccugaccggg aagcucgacg cccggaagau     1620

ccgcgagauc cugaucaagg ccaagaaggg cggcaagauc gccguguaag acuaguuaua     1680

agacugacua gcccgauggg ccucccaacg ggcccuccuc cccuccuugc accgagauua     1740

auaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa     1800

aaaaaauauu cccccccccc cccccccccc cccccccccc ucuagacaau uggaauu        1857


<210>  838
<211>  54
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mp68 (2010107E04Rik) 5-UTR

<400>  838
ctttcccatt ctgtagcaga atttggtgtt gcctgtggtc ttggtcccgc ggag             54


<210>  839
<211>  54
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Mp68 (2010107E04Rik) 5-UTR

<400>  839
cuuucccauu cuguagcaga auuugguguu gccugugguc uuggucccgc ggag             54


<210>  840
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nosip 5-UTR

<400>  840
ctcctgtcgg gcggaagtag gaggagtaga gtttaaaaac agtactcttt ttccggttcg       60

ggacgtagtt gaagcaacga caagccggat aaccgctctt gagacagg                   108


<210>  841
<211>  108
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Nosip 5-UTR

<400>  841
cuccugucgg gcggaaguag gaggaguaga guuuaaaaac aguacucuuu uuccgguucg       60

ggacguaguu gaagcaacga caagccggau aaccgcucuu gagacagg                   108


<210>  842
<211>  62
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HSD17B4 5-UTR

<400>  842
gtcccgcagt cggcgtccag cggctctgct tgttcgtgtg tgtgtcgttg caggccttat       60

tc                                                                      62


<210>  843
<211>  62
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HSD17B4 5-UTR

<400>  843
gucccgcagu cggcguccag cggcucugcu uguucgugug ugugucguug caggccuuau       60

uc                                                                      62


<210>  844
<211>  84
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Rpl31 5-UTR

<400>  844
cccgtgaccc ggaagttgta cggctacgcg actttccctc ccacaaaccc tcgcgccctt       60

cctttcctac ttgggcccgg caga                                              84


<210>  845
<211>  84
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Rpl31 5-UTR

<400>  845
cccgugaccc ggaaguugua cggcuacgcg acuuucccuc ccacaaaccc ucgcgcccuu       60

ccuuuccuac uugggcccgg caga                                              84


<210>  846
<211>  102
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TUBB4B 5-UTR

<400>  846
atataagcgt tggcggagcg tcggttgtag cactctgcgc gcccgctctt ctgctgctgt       60

ttgtctactt cctcctgctt ccccgccgcc gccgccgcca tc                         102


<210>  847
<211>  102
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  TUBB4B 5-UTR

<400>  847
auauaagcgu uggcggagcg ucgguuguag cacucugcgc gcccgcucuu cugcugcugu       60

uugucuacuu ccuccugcuu ccccgccgcc gccgccgcca uc                         102


<210>  848
<211>  75
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ATP5A1 5-UTR

<400>  848
gcggctcggc cattttgtcc cagtcagtcc ggaggctgcg gctgcagaag taccgcctgc       60

ggagtaactg caaag                                                        75


<210>  849
<211>  75
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  ATP5A1 5-UTR

<400>  849
gcggcucggc cauuuugucc cagucagucc ggaggcugcg gcugcagaag uaccgccugc       60

ggaguaacug caaag                                                        75


<210>  850
<211>  81
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Ndufa4 5-UTR

<400>  850
gtccgctcag ccaggttgca gaagcggctt agcgtgtgtc ctaatcttct ctctgcgtgt       60

aggtaggcct gtgccgcaaa c                                                 81


<210>  851
<211>  81
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Ndufa4 5-UTR

<400>  851
guccgcucag ccagguugca gaagcggcuu agcguguguc cuaaucuucu cucugcgugu       60

agguaggccu gugccgcaaa c                                                 81


<210>  852
<211>  70
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RPS9 3-UTR

<400>  852
gtccacctgt ccctcctggg ctgctggatt gtctcgtttt cctgccaaat aaacaggatc       60

agcgctttac                                                              70


<210>  853
<211>  70
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  RPS9 3-UTR

<400>  853
guccaccugu cccuccuggg cugcuggauu gucucguuuu ccugccaaau aaacaggauc       60

agcgcuuuac                                                              70


<210>  854
<211>  57
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PSMB3 3-UTR

<400>  854
ccctgttccc agagcccact tttttttctt tttttgaaat aaaatagcct gtctttc          57


<210>  855
<211>  57
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  PSMB3 3-UTR

<400>  855
cccuguuccc agagcccacu uuuuuuucuu uuuuugaaau aaaauagccu gucuuuc          57


<210>  856
<211>  121
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CASP1 3-UTR

<400>  856
aataaggaaa ctgtatgaat gtctgtgggc aggaagtgaa gagatccttc tgtaaaggtt       60

tttggaatta tgtctgctga ataataaact tttttgaaat aataaatctg gtagaaaaat      120

g                                                                      121


<210>  857
<211>  121
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  CASP1 3-UTR

<400>  857
aauaaggaaa cuguaugaau gucugugggc aggaagugaa gagauccuuc uguaaagguu       60

uuuggaauua ugucugcuga auaauaaacu uuuuugaaau aauaaaucug guagaaaaau      120

g                                                                      121


<210>  858
<211>  137
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  COX6B1 3-UTR

<400>  858
actggctgca tctccctttc ctctgtcctc catccttctc ccaggatggt gaagggggac       60

ctggtaccca gtgatcccca ccccaggatc ctaaatcatg acttacctgc taataaaaac      120

tcattggaaa agtgaga                                                     137


<210>  859
<211>  137
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  COX6B1 3-UTR

<400>  859
acuggcugca ucucccuuuc cucuguccuc cauccuucuc ccaggauggu gaagggggac       60

cugguaccca gugaucccca ccccaggauc cuaaaucaug acuuaccugc uaauaaaaac      120

ucauuggaaa agugaga                                                     137


<210>  860
<211>  1621
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Ipilimumab HC with signale peptide

<400>  860
gggagaaagc uuaccaugga gcugggccuc agcuggaucu uccugcuggc cauccucaag       60

ggggugcagu gccaggugca gcuggucgag agcggcgggg gcguggugca gcccgggcgc      120

ucccuccggc ugagcugcgc cgccuccggc uucaccuuca gcuccuacac caugcacugg      180

guccgccagg cgccggggaa gggccuggag ugggugacgu ucaucagcua cgacggcaac      240

aacaaguacu acgccgacuc cgugaagggg cgguucacca ucagccgcga caacuccaag      300

aacacccucu accugcagau gaacagccug cgggccgagg acaccgccau cuacuacugc      360

gcccgcacgg gcuggcucgg gcccuucgac uacuggggcc aggggacccu ggucaccgug      420

uccagcgcgu ccaccaaggg ccccagcgug uucccccugg ccccguccag caaguccacg      480

agcggcggga ccgccgcccu cggcugccug gucaaggacu acuuccccga gcccgugacc      540

guguccugga acagcggggc gcugaccagc ggcguccaca cguuccccgc cgugcuccag      600

uccagcggcc uguacucccu gagcuccgug gucaccgugc cgagcuccag ccucgggacc      660

cagaccuaca ucugcaacgu gaaccacaag cccuccaaca cgaaggucga caagcgggug      720

gagcccaaga gcugcgacaa gacccacacg ugcccgcccu gccccgcccc cgagcugcug      780

ggcgggcccu ccguguuccu cuucccgccc aagcccaagg acacccugau gaucagccgc      840

acccccgagg ugaccugcgu cguggucgac gugucccacg aggacccgga ggucaaguuc      900

aacugguacg uggacggcgu ggagguccac aacgccaaga ccaagccccg ggaggagcag      960

uacaacagca ccuaccgcgu gguguccguc cugacggugc uccaccagga cuggcugaac     1020

gggaaggagu acaagugcaa ggugagcaac aaggcccugc ccgcgcccau cgagaagacc     1080

aucuccaagg ccaagggcca gccgcgggag ccccaggucu acacccuccc gcccagccgc     1140

gacgagcuga ccaagaacca ggugucccug acgugccucg ugaagggcuu cuaccccagc     1200

gacaucgccg ucgaguggga gagcaacggg cagcccgaga acaacuacaa gaccacgccc     1260

ccggugcugg acuccgacgg cagcuucuuc cuguacucca agcucaccgu ggacaagagc     1320

cgguggcagc aggggaacgu cuucuccugc agcgugaugc acgaggcccu gcacaaccac     1380

uacacccaga agucccugag ccucuccccc ggcaagugag gacuaguuau aagacugacu     1440

agcccgaugg gccucccaac gggcccuccu ccccuccuug caccgagauu aauaaaaaaa     1500

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaugc     1560

aucccccccc cccccccccc cccccccccc cccaaaggcu cuuuucagag ccaccagaau     1620

u                                                                     1621


<210>  861
<211>  1621
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Ipilimumab HC with signale peptide

<400>  861
gggagaaagc uuaccaugga gcucggccuc uccuggaucu uccuccucgc cauccucaag       60

ggcguccagu gccaggucca gcucgucgag uccggcggcg gcgucgucca gcccggccgc      120

ucccuccgcc ucuccugcgc cgccuccggc uucaccuucu ccuccuacac caugcacugg      180

guccgccagg cccccggcaa gggccucgag ugggucaccu ucaucuccua cgacggcaac      240

aacaaguacu acgccgacuc cgucaagggc cgcuucacca ucucccgcga caacuccaag      300

aacacccucu accuccagau gaacucccuc cgcgccgagg acaccgccau cuacuacugc      360

gcccgcaccg gcuggcucgg ccccuucgac uacuggggcc agggcacccu cgucaccguc      420

uccuccgccu ccaccaaggg ccccuccguc uucccccucg cccccuccuc caaguccacc      480

uccggcggca ccgccgcccu cggcugccuc gucaaggacu acuuccccga gcccgucacc      540

gucuccugga acuccggcgc ccucaccucc ggcguccaca ccuuccccgc cguccuccag      600

uccuccggcc ucuacucccu cuccuccguc gucaccgucc ccuccuccuc ccucggcacc      660

cagaccuaca ucugcaacgu caaccacaag cccuccaaca ccaaggucga caagcgcguc      720

gagcccaagu ccugcgacaa gacccacacc ugcccccccu gccccgcccc cgagcuccuc      780

ggcggccccu ccgucuuccu cuuccccccc aagcccaagg acacccucau gaucucccgc      840

acccccgagg ucaccugcgu cgucgucgac gucucccacg aggaccccga ggucaaguuc      900

aacugguacg ucgacggcgu cgagguccac aacgccaaga ccaagccccg cgaggagcag      960

uacaacucca ccuaccgcgu cgucuccguc cucaccgucc uccaccagga cuggcucaac     1020

ggcaaggagu acaagugcaa ggucuccaac aaggcccucc ccgcccccau cgagaagacc     1080

aucuccaagg ccaagggcca gccccgcgag ccccaggucu acacccuccc ccccucccgc     1140

gacgagcuca ccaagaacca ggucucccuc accugccucg ucaagggcuu cuaccccucc     1200

gacaucgccg ucgaguggga guccaacggc cagcccgaga acaacuacaa gaccaccccc     1260

cccguccucg acuccgacgg cuccuucuuc cucuacucca agcucaccgu cgacaagucc     1320

cgcuggcagc agggcaacgu cuucuccugc uccgucaugc acgaggcccu ccacaaccac     1380

uacacccaga agucccucuc ccucuccccc ggcaagugag gacuaguuau aagacugacu     1440

agcccgaugg gccucccaac gggcccuccu ccccuccuug caccgagauu aauaaaaaaa     1500

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaugc     1560

aucccccccc cccccccccc cccccccccc cccaaaggcu cuuuucagag ccaccagaau     1620

u                                                                     1621


<210>  862
<211>  1621
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Ipilimumab HC with signale peptide

<400>  862
gggagaaagc uuaccaugga gcugggccuc agcuggaucu uccuucuggc cauuuugaag       60

ggggugcagu gccaagucca guuaguugaa uccggaggug gcgugguaca gcccgggaga      120

ucucugaggc uaucaugugc ugcaagugga uuuaccuuca gcuccuacac aaugcacugg      180

gugcggcagg ccccuggcaa aggucucgag ugggucacuu uuauaucuua ugacgggaac      240

aauaaguacu augcggauuc ggugaaagga cgcuucacga ucucacgaga caacagcaag      300

aauacccugu accuucaaau gaacagucug cgugcugaag auacagccau uuauuacugc      360

gcaagaacug gcugguuggg cccauuugac uauugggggc agggaacccu cguuacagug      420

uccucugcca gcaccaaagg uccguccguc uucccccugg cuccuucaag uaagagcacu      480

ucuggcggga cagcagcccu gggaugucuc gugaaggauu acuuuccaga gcccguaacc      540

guuuccugga acucaggcgc uuuaacgagc ggugugcaua cuuucccugc cguccugcag      600

aguucugggc uuuacuccuu gagcucggug gugaccgucc caucuuccuc acugggaaca      660

cagacuuaua ucugcaaugu uaaucacaaa cccaguaaca ccaaggugga caaaagggua      720

gaaccuaaga gcugugauaa aacacauacc ugcccaccgu gucccgcgcc ugagcuacuc      780

ggcggcccau ccguguuucu guuucccccu aagccaaagg acacgcuuau gauuucucgg      840

acucccgagg ucacaugcgu gguuguggau gucagccacg aagacccgga ggugaaauuu      900

aauugguacg uagauggggu ugaagugcau aacgcaaaga ccaaaccucg cgaggagcaa      960

uauaauucaa cuuacagagu cgugaguguc cugacagugu ugcaccagga cuggcucaac     1020

ggaaaggaau auaaauguaa gguuuccaau aaagcccugc ccgcuccaau cgagaagacc     1080

auaagcaagg ccaaagguca gccuagggaa ccccaggugu acacguuacc acccucucgg     1140

gaugagcuga ccaagaacca aguaucacuc acaugccuug ucaaaggcuu cuauccuagu     1200

gacaucgcag uggaauggga gagcaauggg cagccagaga acaacuacaa gacuaccccg     1260

cccguucugg acuccgaugg aucuuucuuc uuguacucga aacuaacagu ggacaagagc     1320

cgcuggcagc aaggcaaugu cuucuccugu ucagugaugc acgaagcucu gcauaaccac     1380

uauacucaga agagucucuc ucugagcccu gguaaaugag gacuaguuau aagacugacu     1440

agcccgaugg gccucccaac gggcccuccu ccccuccuug caccgagauu aauaaaaaaa     1500

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaugc     1560

aucccccccc cccccccccc cccccccccc cccaaaggcu cuuuucagag ccaccagaau     1620

u                                                                     1621


<210>  863
<211>  1621
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Ipilimumab HC with signale peptide

<400>  863
gggagaaagc uuaccaugga gcugggccug agcuggaucu uccugcuggc cauccugaag       60

ggcgugcagu gccaggugca gcugguggag agcggcggcg gcguggugca gcccggcaga      120

agccugagac ugagcugcgc cgccagcggc uucaccuuca gcagcuacac caugcacugg      180

gugagacagg cccccggcaa gggccuggag ugggugaccu ucaucagcua cgacggcaac      240

aacaaguacu acgccgacag cgugaagggc agauucacca ucagcagaga caacagcaag      300

aacacccugu accugcagau gaacagccug agagccgagg acaccgccau cuacuacugc      360

gccagaaccg gcuggcuggg ccccuucgac uacuggggcc agggcacccu ggugaccgug      420

agcagcgcca gcaccaaggg ccccagcgug uucccccugg cccccagcag caagagcacc      480

agcggcggca ccgccgcccu gggcugccug gugaaggacu acuuccccga gcccgugacc      540

gugagcugga acagcggcgc ccugaccagc ggcgugcaca ccuuccccgc cgugcugcag      600

agcagcggcc uguacagccu gagcagcgug gugaccgugc ccagcagcag ccugggcacc      660

cagaccuaca ucugcaacgu gaaccacaag cccagcaaca ccaaggugga caagagagug      720

gagcccaaga gcugcgacaa gacccacacc ugcccccccu gccccgcccc cgagcugcug      780

ggcggcccca gcguguuccu guuccccccc aagcccaagg acacccugau gaucagcaga      840

acccccgagg ugaccugcgu ggugguggac gugagccacg aggaccccga ggugaaguuc      900

aacugguacg uggacggcgu ggaggugcac aacgccaaga ccaagcccag agaggagcag      960

uacaacagca ccuacagagu ggugagcgug cugaccgugc ugcaccagga cuggcugaac     1020

ggcaaggagu acaagugcaa ggugagcaac aaggcccugc ccgcccccau cgagaagacc     1080

aucagcaagg ccaagggcca gcccagagag ccccaggugu acacccugcc ccccagcaga     1140

gacgagcuga ccaagaacca ggugagccug accugccugg ugaagggcuu cuaccccagc     1200

gacaucgccg uggaguggga gagcaacggc cagcccgaga acaacuacaa gaccaccccc     1260

cccgugcugg acagcgacgg cagcuucuuc cuguacagca agcugaccgu ggacaagagc     1320

agauggcagc agggcaacgu guucagcugc agcgugaugc acgaggcccu gcacaaccac     1380

uacacccaga agagccugag ccugagcccc ggcaagugag gacuaguuau aagacugacu     1440

agcccgaugg gccucccaac gggcccuccu ccccuccuug caccgagauu aauaaaaaaa     1500

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaugc     1560

aucccccccc cccccccccc cccccccccc cccaaaggcu cuuuucagag ccaccagaau     1620

u                                                                     1621


<210>  864
<211>  1621
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Ipilimumab HC with signale peptide

<400>  864
gggagaaagc uuaccaugga gcugggccuc agcuggaucu uccugcuugc cauucugaag       60

ggggugcagu gccaagucca gcucguugaa uccggaggcg ggguggugca gcccggaaga      120

ucucugcggc uuagcugugc ugccuccggc uuuaccuucu cuagcuacac aaugcacugg      180

guccgccagg cgccugggaa aggacuggag ugggugacgu uuaucuccua ugacggcaac      240

aauaaguacu augcugauuc uguuaaaggc agauucacca uuagccggga caacuccaag      300

aauacacucu accugcaaau gaacagccug cgcgccgaag auaccgccau cuauuacugc      360

gcuagaacag gguggcucgg accguuugac uauuggggcc aggggacccu ggugacaguc      420

ucuuccgcca gcaccaaagg acccucugug uucccucuug cucccuccag caagucuacg      480

uccggcggga ccgccgcgcu gggaugucuc guuaaggauu acuuuccuga gcccgugaca      540

gucagcugga acuccggcgc ccugaccucu ggcgugcaua cauucccugc ugugcuucag      600

agcuccgggc uguacagccu cucuuccguc guuaccgugc cgagcucuag ccugggaacg      660

cagacauaua uuugcaaugu gaaucacaaa cccuccaaca ccaaggucga caaacgggug      720

gaaccuaagu cuugugauaa aacacauacc ugucccccuu gccccgcccc ggagcugcuc      780

ggcgggccua gcguuuuucu guuucccccu aagcccaagg acacccuuau gaucucccgc      840

acacccgagg ugacgugcgu cgugguugau gugagccacg aagacccuga ggucaaauuc      900

aauugguacg uggauggagu cgaagugcau aacgcuaaga ccaaaccgag agaggagcaa      960

uauaauucua cauaccgggu uguguccguc cugaccgugc uccaccagga cuggcugaac     1020

ggcaaggaau auaaauguaa gguuagcaau aaagcccuuc ccgcgccuau cgagaagaca     1080

auuucuaagg ccaaagggca gccccgcgaa ccucaggugu acacccugcc cccguccaga     1140

gaugagcuca cgaagaacca agucagccug acaugccugg ugaaaggauu cuauccuucc     1200

gacaucgcug uggaauggga gucuaauggc cagcccgaga acaacuacaa gaccaccccu     1260

cccguucucg acagcgaugg cuccuuuuuc cuguacucua aacuuacagu cgacaagagc     1320

cgguggcagc aagggaaugu guucuccugu agcgugaugc acgaagcccu gcauaaccac     1380

uauacccaga agucucucuc ccugagcccu ggaaaaugag gacuaguuau aagacugacu     1440

agcccgaugg gccucccaac gggcccuccu ccccuccuug caccgagauu aauaaaaaaa     1500

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaugc     1560

aucccccccc cccccccccc cccccccccc cccaaaggcu cuuuucagag ccaccagaau     1620

u                                                                     1621


<210>  865
<211>  1621
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Ipilimumab HC with signale peptide

<400>  865
gggagaaagc uuaccaugga auuagguuua uccuggaucu uucuccuagc aauacucaaa       60

ggaguacaau gccaaguaca auuaguggaa uccggaggag guguaguaca accaggaaga      120

ucacuaagac uaucaugcgc agcaucagga uuuacauucu caucauacac aaugcacugg      180

guaagacaag ccccaggaaa aggauuagaa uggguuacau uuauauccua cgacggaaac      240

aauaaauacu acgcagacuc agucaaagga agauucacua uaucaagaga caauucuaaa      300

aacacacuau accuacaaau gaacucucuc cgagcagaag auacagccau auacuacugc      360

gcaagaacag gaugguuagg accuuucgac uacuggggac aaggaacucu aguaacuguc      420

ucaucugccu caacaaaagg cccaucagua uuuccacuag ccccaucauc uaaaucuaca      480

ucagguggaa ccgcugcauu aggaugcuua guaaaagacu auuuucccga accaguaacu      540

guaucuugga acuccggagc acuuacuucu gguguacaca cauucccagc aguuuuacaa      600

agcucaggac uauacucucu aagcucagua guaacugucc caucaucauc ccuuggcacc      660

caaacauaca uauguaacgu aaaucacaaa cccaguaaua ccaaaguaga caaaagagua      720

gaacccaaau caugugauaa aacacacaca ugcccccccu gcccagcacc ugaacuucua      780

ggaggaccau cuguauuccu cuucccucca aaaccaaaag auacucucau gauaucacgc      840

acacccgaag uaacuugugu cguaguagac guaucacacg aagacccaga aguuaaauuc      900

aacugguaug uagacggagu agaaguccac aacgcaaaaa caaaaccacg agaagaacaa      960

uacaacucca ccuaucgcgu aguuucagua cuuacaguuc uccaccaaga uuggcuaaac     1020

ggaaaagaau acaaaugcaa aguaucaaau aaagcuuuac cugcaccaau agaaaaaaca     1080

auaaguaaag caaaagguca accacgagaa ccccaaguau auacacuucc accaucaaga     1140

gacgaacuua ccaaaaacca agucucacuc acaugcuuag uaaaaggauu uuacccauca     1200

gauauagcag uagaauggga auccaaugga caaccagaaa auaauuacaa aaccacacca     1260

ccuguacuag auucagacgg cucuuucuuu cuauacucua aacuaacagu ugauaaauca     1320

cgauggcaac aaggcaaugu auucucuugu ucugucaugc augaagcacu acacaaccac     1380

uacacacaaa aaucacuauc acuauccccc ggcaaaugag gacuaguuau aagacugacu     1440

agcccgaugg gccucccaac gggcccuccu ccccuccuug caccgagauu aauaaaaaaa     1500

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaugc     1560

aucccccccc cccccccccc cccccccccc cccaaaggcu cuuuucagag ccaccagaau     1620

u                                                                     1621


<210>  866
<211>  1621
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Ipilimumab HC with signale peptide

<400>  866
gggagaaagc uuaccaugga gcugggccuc agcuggaucu uccuguuggc cauucugaag       60

ggggugcagu gccaagucca gcucguggaa uccgguggcg ggguagugca gcccggcagg      120

agucugcggu ugagcugugc agccuccggu uuuaccuuca guagcuacac uaugcacugg      180

guccgccagg cgccagggaa aggccuggag ugggugaccu uuaucuccua ugacggcaac      240

aauaaguacu augccgauag cgugaaaggg agguucacga uuucccggga caacaguaag      300

aauacucucu accugcaaau gaacagccug cgcgcagaag auaccgccau cuauuacugc      360

gcaaggaccg guuggcucgg cccguuugac uauugggggc agggcacucu ggucaccgug      420

uccagcgcca guacgaaagg ucccuccgua uucccauugg cgcccagcuc caagaguacu      480

agcgggggca ccgccgcacu gggcugucuc gugaaggauu acuuuccaga gcccgucacu      540

guguccugga auagcggggc ccugaccagu ggugugcaua ccuucccagc cguccugcag      600

uccagcggcu uguacagucu cuccagcgug guaacggugc cgagcuccag ucuggggacu      660

cagaccuaua uuugcaacgu caaucacaaa cccagcaaca cuaaggugga caaacgggug      720

gaaccaaagu ccugugauaa aacccauacc ugucccccau gccccgcacc ggagcugcuc      780

ggcgguccca gcgucuuucu guucccaccc aagccaaaag acacuuugau gaucagucgc      840

acgcccgagg ugaccugcgu aguggucgau gugucccacg aagacccaga ggucaaguuu      900

aauugguacg uggauggcgu ggaaguacau aacgccaaga cuaaaccgag ggaggagcaa      960

uauaauagca ccuaccgggu ggucuccgug cugaccgucc uccaccagga cuggcugaac     1020

gggaaggaau auaaauguaa ggugaguaau aaagcgcugc ccgccccaau cgagaagacu     1080

auuagcaagg caaaaggcca gccccgcgaa ccacaggugu acacguugcc cccguccagg     1140

gaugagcuca ccaagaacca aguaagccug acuugccugg ugaaaggguu cuauccaagu     1200

gacaucgccg ucgaauggga guccaauggu cagcccgaga acaacuacaa gaccacuccc     1260

ccagugcucg acagcgaugg cuccuucuuu cuguacagua aauugaccgu cgacaagagc     1320

cgguggcagc aagggaaugu guucuccugc agcgugaugc acgaagcacu gcauaaccac     1380

uauacgcaga agagucucuc ccugagcccc ggcaaaugag gacuaguuau aagacugacu     1440

agcccgaugg gccucccaac gggcccuccu ccccuccuug caccgagauu aauaaaaaaa     1500

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaugc     1560

aucccccccc cccccccccc cccccccccc cccaaaggcu cuuuucagag ccaccagaau     1620

u                                                                     1621


<210>  867
<211>  1621
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Ipilimumab HC with signale peptide

<400>  867
gggagaaagc uuaccaugga acucggccua agcuggaucu uccuccuggc cauccucaaa       60

ggcguacagu gccaggucca acucguagaa uccggaggcg gcgucguaca acccggccgc      120

ucccuccgcc uauccugcgc agcuuccggc uucacauuca guucauacac caugcacugg      180

guccgacaag cccccggcaa aggacucgaa ugggucacuu uuaucucuua cgacggcaac      240

aauaaauacu acgcagacuc cgucaaaggc cgcuuuacaa ucucacguga caacuccaaa      300

aacacccuau accuccaaau gaacucccua cgcgcugaag acaccgccau uuacuauugc      360

gcccgcacag gcuggcuugg accauucgac uacuggggac aaggaacccu ugucaccguc      420

uccucugcca gcaccaaagg ccccuccguc uucccccucg cucccagcuc caaauccacg      480

ucaggcggca cugcagcccu cggaugccua gucaaagacu acuuccccga acccgucaca      540

gucucaugga acuccggagc ccucacuuca ggcguccaca ccuuccccgc aguacuacaa      600

ucuucaggcc uauacucccu aagcuccguc gucaccguac ccuccucauc ccucggaaca      660

caaaccuaca uaugcaacgu caaccacaaa cccucaaaca caaaaguaga caaacgcguc      720

gaacccaaau ccugcgacaa aacccauacc ugcccacccu gccccgcccc ggaacuccua      780

ggcggcccca gcgucuucuu auucccaccc aaacccaaag acacgcucau gauaaguaga      840

acccccgaag ugaccugcgu cgucgucgac gucucccacg aagacccuga aguuaaauuc      900

aacugguacg ucgacggcgu cgaaguucac aacgccaaaa ccaaaccccg agaagaacaa      960

uacaacucca ccuaccgagu cgucucagua cuaacagucc uccaccaaga cuggcucaac     1020

ggaaaagaau acaaaugcaa agucuccaac aaagcacuac cugccccaau cgagaaaaca     1080

aucuccaaag ccaaaggaca accccgugaa ccccagguau acacccuacc cccaucacgc     1140

gacgaacuca ccaaaaauca ggucagccua accugccucg ucaaaggauu cuaccccucc     1200

gacaucgccg ucgaauggga aagcaacggc caacccgaaa acaacuacaa aaccacccca     1260

cccguacucg acuccgacgg cuccuucuuc cucuacucca agcucaccgu cgacaaaucc     1320

cgcuggcaac agggaaacgu auucuccugc uccgucaugc acgaagcccu ccacaaccac     1380

uauacccaaa aaucacucuc ccuaucaccc ggaaaauaag gacuaguuau aagacugacu     1440

agcccgaugg gccucccaac gggcccuccu ccccuccuug caccgagauu aauaaaaaaa     1500

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaugc     1560

aucccccccc cccccccccc cccccccccc cccaaaggcu cuuuucagag ccaccagaau     1620

u                                                                     1621


<210>  868
<211>  1621
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Ipilimumab HC with signale peptide

<400>  868
gggagaaagc uuaccaugga acuaggccua ucauggaucu uccuccucgc cauccucaaa       60

ggcguccaau gccaggucca acucgucgaa uccggcggag gcgucgucca acccggccga      120

ucacuccgcc ucuccugcgc cgccuccggc uucacuuucu ccuccuacac aaugcacugg      180

guacgccaag ccccaggaaa aggacucgaa ugggucaccu ucaucuccua cgacggaaac      240

aacaaauacu acgccgacag cguuaaagga cgauucacaa ucucccgcga caacucuaaa      300

aacacccuau accuccaaau gaacucccuc cgcgccgaag acacagcaau cuacuacugc      360

gccagaaccg gauggcuagg ccccuucgac uacuggggcc aaggaacccu cgucacagua      420

uccuccgccu ccaccaaagg cccuuccgua uuuccccugg cccccucauc caaauccacc      480

agcggcggaa ccgccgcacu uggcugccuc guaaaagacu acuuccccga acccguaacc      540

gucuccugga acagcggcgc ccuaacguca ggcguacaca ccuuccccgc aguccuccaa      600

uccuccggac uauauagccu cuccagcgua guaacaguac ccuccagcuc ucucggcaca      660

caaaccuaua ucugcaacgu aaaccacaaa cccagcaaca ccaaaguuga caaacgcguu      720

gaacccaaau ccugcgacaa aacccacaca ugcccacccu gccccgcccc cgaacuccuc      780

ggcggucccu cagucuuccu cuucccacca aaaccuaaag acacucuaau gauaucccgc      840

accccagaag ugaccugcgu cguagucgac gucucccacg aagaccccga agucaaauuc      900

aacugguacg ucgacggcgu cgaaguacac aacgccaaaa ccaaaccccg agaagaacaa      960

uacaacucaa ccuacagagu cgucagcguc cucaccgucc uccaucagga cuggcucaac     1020

ggaaaagaau acaaaugcaa agucuccaac aaagcccuac cagcacccau agagaaaacc     1080

aucuccaaag ccaagggcca accacgcgaa ccccaaguau acacacuccc acccucacga     1140

gacgaacuca ccaagaacca aguaucuuua accugccuug ucaaaggcuu cuaccccucc     1200

gacaucgccg uggaauggga auccaacgga caacccgaaa acaacuacaa gaccacacca     1260

cccguccuug acucagacgg cuccuucuuc cucuauucca aacuuaccgu cgacaaaucc     1320

cgauggcaac aaggcaacgu cuucuccugc ucaguaaugc acgaagcccu acacaaccac     1380

uacacgcaaa aaucacucuc ccuguccccc ggaaaaugag gacuaguuau aagacugacu     1440

agcccgaugg gccucccaac gggcccuccu ccccuccuug caccgagauu aauaaaaaaa     1500

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaugc     1560

aucccccccc cccccccccc cccccccccc cccaaaggcu cuuuucagag ccaccagaau     1620

u                                                                     1621


<210>  869
<211>  1621
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Ipilimumab HC with signale peptide

<400>  869
gggagaaagc uuaccaugga acuuggccuu uccuggaucu uccuccucgc cauacucaaa       60

ggcguccaau gccaaguuca gcuagucgaa uccgguggcg gcguagucca acccggacgc      120

agccuccgac uauccugcgc cgccuccgga uucaccuucu ccucauacac caugcacugg      180

guccgccaag cccccggcaa aggccucgaa ugggucacau ucaucuccua cgauggaaac      240

aacaaauacu acgccgacuc agucaaaggc cgcuucacaa ucucccgaga caacuccaaa      300

aacacccuau accuccaaau gaacucacuu agagccgaag acacagcaau auacuacugc      360

gcccgcaccg gauggcuagg acccuucgac uacuggggcc aagggacccu cgucaccguu      420

agcuccgccu ccacaaaagg acccuccgua uucccccucg ccccauccuc caaauccaca      480

ucuggcggca ccgccgcacu cggaugccuc guaaaagacu acuuccccga acccgucaca      540

gucagcugga acucaggcgc ucucaccucc ggcguccaca cauucccggc aguccugcaa      600

agcagcggcc ucuacucccu aucaucugua gucaccgucc cauccucuuc ccucggcacc      660

caaaccuaca ucugcaacgu aaaccacaaa cccagcaaca ccaaagugga uaaacgagua      720

gaacccaaau cuugcgacaa aacccacacu ugcccacccu gccccgcccc agaacuucua      780

ggcggacccu ccgucuuccu cuucccaccc aaacccaaag acacccucau gaucucacgc      840

acccccgagg uaaccugcgu ugucgucgac gugucccacg aagacccuga agucaaguuc      900

aacugguacg ucgacggcgu cgaagugcac aacgccaaaa caaaaccacg cgaagaacaa      960

uauaacucaa ccuaccgcgu agucuccguc cuaaccgucc uccaccaaga cuggcuaaac     1020

ggcaaagaau acaaauguaa aguauccaau aaagcacucc ccgcccccau agagaaaacg     1080

aucuccaagg ccaaagguca accacgcgaa ccccaaguau acacccuacc accaucccgc     1140

gacgaacuca ccaaaaacca aguaucccua accugccuag ucaaaggcuu cuaccccucc     1200

gacaucgcag uagaauggga auccaacggc caaccagaaa acaacuacaa gacaacaccu     1260

cccguccucg acuccgacgg auccuucuuc uuauacucaa aacuaaccgu cgacaaaucu     1320

agauggcaac aaggcaacgu cuucucaugc uccguaaugc acgaagcucu ccacaaccac     1380

uacacccaaa aaucacucuc ccucuccccc ggcaaaugag gacuaguuau aagacugacu     1440

agcccgaugg gccucccaac gggcccuccu ccccuccuug caccgagauu aauaaaaaaa     1500

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaugc     1560

aucccccccc cccccccccc cccccccccc cccaaaggcu cuuuucagag ccaccagaau     1620

u                                                                     1621


<210>  870
<211>  1621
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Ipilimumab HC with signale peptide

<400>  870
gggagaaagc uuaccaugga acuaggacuc ucauggauau uuuuacuagc cauacucaaa       60

ggcguccaau gucaaguaca acuaguagaa ucaggcggag gaguugucca acccggccga      120

ucccuccgcu uaucaugugc agcaucugga uucacauuuu caucauacac aaugcacugg      180

gucagacaag ccccaggaaa agguuuagaa uggguaacau uuauaucaua cgacgguaac      240

aacaaauacu augcagacuc aguaaaagga agauuuacaa ucagcagaga caauagcaaa      300

aacacacuau accuacaaau gaacucccua cgagcagaag acacagccau cuauuacugu      360

gcacgaacag gauggcuagg accauucgau uacuggggcc aaggaacauu agucaccgua      420

ucuucugcau ccacaaaagg uccuucagua uuuccauuag cacccagcuc caaaucuaca      480

ucuggcggaa cagccgccuu aggaugcuua guuaaagauu acuuuccaga accaguaaca      540

guuucaugga acucaggagc ucuaacaucu ggaguacaca cauuuccagc aguccuacaa      600

ucauccggac uauauucacu aucaucagua guaacugucc ccucaucauc auuaggcaca      660

caaacuuaua uuugcaaugu aaaccauaaa ccaucaaaua caaaagucga caaaagagua      720

gaaccaaaau caugcgacaa aacccacaca uguccacccu gccccgcccc agaauuauua      780

ggaggaccau cugucuuccu uuucccacca aaaccaaaag acaccuuaau gauaucucga      840

acuccagaag uaacaugugu aguuguagau guuucacaug aagacccaga aguaaaauuc      900

aacugguacg ucgacggagu agaaguacac aaugcaaaaa caaaaccccg agaagaacaa      960

uacaacucca cauacagagu agucucagua cuaacaguac uccaucaaga cuggcuaaac     1020

ggaaaagaau acaaauguaa aguaaguaau aaagcacuac ccgcaccaau agaaaaaaca     1080

auaucaaaag caaaaggaca accaagagaa ccacaaguau auacacuacc uccauccaga     1140

gaugaauuaa caaaaaacca aguaagucua acauguuuag uaaaaggauu cuaucccagc     1200

gacauagcag ucgaauggga aucaaaugga caaccagaaa acaacuauaa aaccacacca     1260

ccaguauuag auucagacgg aucauuuuuc cuuuacucaa aauuaacagu agacaaaucc     1320

agauggcaac aaggcaaugu cuuuucaugc ucugucaugc acgaagcucu acauaaucac     1380

uacacucaaa aaucacuauc acucucacca ggcaaaugag gacuaguuau aagacugacu     1440

agcccgaugg gccucccaac gggcccuccu ccccuccuug caccgagauu aauaaaaaaa     1500

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaugc     1560

aucccccccc cccccccccc cccccccccc cccaaaggcu cuuuucagag ccaccagaau     1620

u                                                                     1621


<210>  871
<211>  1621
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Ipilimumab HC with signale peptide

<400>  871
gggagaaagc uuaccaugga acuaggacua uccuggauau uucuacuagc cauccuaaaa       60

ggaguacaau gucaaguaca auuaguagaa uccggaggcg gaguagucca acccggaaga      120

ucacuaagac ucaguugugc agcaucagga uucacauuuu caucauauac aaugcacugg      180

guuagacaag cacccggaaa aggacucgaa uggguaaccu uuaucuccua cgauggaaac      240

aauaaauauu acgcagauuc uguaaaaggc cgauucacaa uaucaagaga caacucuaaa      300

aauacauuau accuacaaau gaacucuuua agagcagaag acacagcaau auauuacugu      360

gcaagaacag gauggcucgg accauucgac uauuggggac aaggaaccuu aguaacagua      420

uccagcgcua gcacaaaagg cccuucuguc uucccauuag caccauccuc aaaaucaacu      480

ucuggcggaa cagcagcucu aggaugcuua guaaaagauu auuuuccaga accaguuacu      540

guauccugga acucaggagc acuaaccagu ggaguucaca cauuuccagc cguauuacaa      600

ucauccggau uauauucauu aucauccguc guaaccguac caagcucauc auuaggaaca      660

caaacauaca uaugcaacgu aaaucacaaa ccauccaaua caaaaguaga uaaaagagua      720

gaaccuaaau ccugugauaa aacacacaca ugcccaccau gcccagcacc agaauuacua      780

ggaggaccau caguauuccu auucccacca aaaccaaaag auacacuaau gauaucaaga      840

acaccagaag uaacuugugu agucguagac gucucacaug aagacccaga aguaaaauuu      900

aauugguaug uugacggagu cgaaguacac aacgccaaaa caaaaccacg agaagaacaa      960

uacaacucaa cauauagagu aguaucugua uuaacaguau uacaucaaga uugguuaaac     1020

ggaaaagaau acaaauguaa aguaucaaau aaagcucuac cagcaccaau agaaaagaca     1080

aucucaaaag caaaaggcca accucgagaa ccacaaguau acacacuacc accaucaaga     1140

gacgaauuaa ccaaaaacca agucucauua acaugcuuag uuaaagguuu cuaccccagc     1200

gacaucgcag uugaauggga aucaaacggu caaccugaaa acaacuauaa aacaacacca     1260

ccaguuuuag acucagaugg auccuuuuuc uuauacucaa aauuaacagu ugacaaauca     1320

agauggcaac aaggaaaugu cuuuucaugu uccgucaugc augaagcacu acacaaccau     1380

uacacccaaa aaucacucuc acuaucaccc gguaaauaag gacuaguuau aagacugacu     1440

agcccgaugg gccucccaac gggcccuccu ccccuccuug caccgagauu aauaaaaaaa     1500

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaugc     1560

aucccccccc cccccccccc cccccccccc cccaaaggcu cuuuucagag ccaccagaau     1620

u                                                                     1621


<210>  872
<211>  1621
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Ipilimumab backbone Rituximab HC with signale peptide

<400>  872
gggagaaagc uuaccaugga gcugggccuc agcuggaucu uccugcuggc cauccucaag       60

ggggugcagu gccaggugca gcuggucgag agcggcgggg gcguggugca gcccgggcgc      120

ucccuccggc ugagcugcgc cgccuccggc uucaccuuca gcuccuacac caugcacugg      180

guccgccagg cgccggggaa gggccuggag ugggugacgu ucaucagcua cgacggcaac      240

aacaaguacu acgccgacuc cgugaagggg cgguucacca ucagccgcga caacuccaag      300

aacacccucu accugcagau gaacagccug cgggccgagg acaccgccau cuacuacugc      360

gcccgcacgg gcuggcucgg gcccuucgac uacuggggcc aggggacccu ggucaccgug      420

uccagcgcgu ccaccaaggg ccccagcgug uucccccugg ccccguccag caaguccacg      480

agcggcggga ccgccgcccu cggcugccug gucaaggacu acuuccccga gcccgugacc      540

guguccugga acagcggggc gcugaccagc ggcguccaca cguuccccgc cgugcuccag      600

uccagcggcc uguacucccu gagcuccgug gucaccgugc cgagcuccag ccucgggacc      660

cagaccuaca ucugcaacgu gaaccacaag cccuccaaca cgaaggucga caagcgggug      720

gagcccaaga gcugcgacaa gacccacacg ugcccgcccu gccccgcccc cgagcugcug      780

ggcggcccga gcguguuccu cuucccgccc aagcccaagg acacccugau gaucagccgc      840

acccccgagg ucacgugcgu gguggucgac gugagccacg aggaccccga ggugaaguuc      900

aacugguacg ucgacggggu ggaggugcac aacgccaaga ccaagccccg ggaggagcag      960

uacaacagca ccuaccgcgu cgugagcgug cugaccgucc uccaccagga cuggcugaac     1020

ggcaaggagu acaagugcaa ggugucgaac aaggcccugc cggcccccau cgagaagacg     1080

aucagcaagg cgaagggcca gccgcgggag ccccaggucu acacccuccc gcccagccgc     1140

gacgagcuga ccaagaacca ggugucccug acgugccucg ugaagggcuu cuaccccagc     1200

gacaucgccg ucgaguggga gagcaacggg cagcccgaga acaacuacaa gaccacgccc     1260

ccggugcugg acuccgacgg cagcuucuuc cuguacucca agcucaccgu ggacaagagc     1320

cgguggcagc aggggaacgu cuucuccugc agcgugaugc acgaggcccu gcacaaccac     1380

uacacccaga agucccugag ccucuccccc ggcaagugag gacuaguuau aagacugacu     1440

agcccgaugg gccucccaac gggcccuccu ccccuccuug caccgagauu aauaaaaaaa     1500

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaugc     1560

aucccccccc cccccccccc cccccccccc cccaaaggcu cuuuucagag ccaccagaau     1620

u                                                                     1621


<210>  873
<211>  1621
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Ipilimumab backbone Rituximab HC with signale peptide

<400>  873
gggagaaagc uuaccaugga gcugggccuc agcuggaucu uccuucuggc cauuuugaag       60

ggggugcagu gccaagucca guuaguugaa uccggaggug gcgugguaca gcccgggaga      120

ucucugaggc uaucaugugc ugcaagugga uuuaccuuca gcuccuacac aaugcacugg      180

gugcggcagg ccccuggcaa aggucucgag ugggucacuu uuauaucuua ugacgggaac      240

aauaaguacu augcggauuc ggugaaagga cgcuucacga ucucacgaga caacagcaag      300

aauacccugu accuucaaau gaacagucug cgugcugaag auacagccau uuauuacugc      360

gcaagaacug gcugguuggg cccauuugac uauugggggc agggaacccu cguuacagug      420

uccucugcca gcaccaaagg uccguccguc uucccccugg cuccuucaag uaagagcacu      480

ucuggcggga cagcagcccu gggaugucuc gugaaggauu acuuuccaga gcccguaacc      540

guuuccugga acucaggcgc uuuaacgagc ggugugcaua cuuucccugc cguccugcag      600

aguucugggc uuuacuccuu gagcucggug gugaccgucc caucuuccuc acugggaaca      660

cagacuuaua ucugcaaugu uaaucacaaa cccaguaaca ccaaggugga caaaagggua      720

gaaccuaaga gcugugauaa aacacauacc ugcccaccgu gucccgcccc cgagcugcug      780

ggcggcccga gcguguuccu cuucccgccc aagcccaagg acacccugau gaucagccgc      840

acccccgagg ucacgugcgu gguggucgac gugagccacg aggaccccga ggugaaguuc      900

aacugguacg ucgacggggu ggaggugcac aacgccaaga ccaagccccg ggaggagcag      960

uacaacagca ccuaccgcgu cgugagcgug cugaccgucc uccaccagga cuggcugaac     1020

ggcaaggagu acaagugcaa ggugucgaac aaggcccugc cggcccccau cgagaagacg     1080

aucagcaagg cgaaggguca gccuagggaa ccccaggugu acacguuacc acccucucgg     1140

gaugagcuga ccaagaacca aguaucacuc acaugccuug ucaaaggcuu cuauccuagu     1200

gacaucgcag uggaauggga gagcaauggg cagccagaga acaacuacaa gacuaccccg     1260

cccguucugg acuccgaugg aucuuucuuc uuguacucga aacuaacagu ggacaagagc     1320

cgcuggcagc aaggcaaugu cuucuccugu ucagugaugc acgaagcucu gcauaaccac     1380

uauacucaga agagucucuc ucugagcccu gguaaaugag gacuaguuau aagacugacu     1440

agcccgaugg gccucccaac gggcccuccu ccccuccuug caccgagauu aauaaaaaaa     1500

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaugc     1560

aucccccccc cccccccccc cccccccccc cccaaaggcu cuuuucagag ccaccagaau     1620

u                                                                     1621


<210>  874
<211>  1621
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Ipilimumab backbone Rituximab HC with signale peptide

<400>  874
gggagaaagc uuaccaugga gcugggccug agcuggaucu uccugcuggc cauccugaag       60

ggcgugcagu gccaggugca gcugguggag agcggcggcg gcguggugca gcccggcaga      120

agccugagac ugagcugcgc cgccagcggc uucaccuuca gcagcuacac caugcacugg      180

gugagacagg cccccggcaa gggccuggag ugggugaccu ucaucagcua cgacggcaac      240

aacaaguacu acgccgacag cgugaagggc agauucacca ucagcagaga caacagcaag      300

aacacccugu accugcagau gaacagccug agagccgagg acaccgccau cuacuacugc      360

gccagaaccg gcuggcuggg ccccuucgac uacuggggcc agggcacccu ggugaccgug      420

agcagcgcca gcaccaaggg ccccagcgug uucccccugg cccccagcag caagagcacc      480

agcggcggca ccgccgcccu gggcugccug gugaaggacu acuuccccga gcccgugacc      540

gugagcugga acagcggcgc ccugaccagc ggcgugcaca ccuuccccgc cgugcugcag      600

agcagcggcc uguacagccu gagcagcgug gugaccgugc ccagcagcag ccugggcacc      660

cagaccuaca ucugcaacgu gaaccacaag cccagcaaca ccaaggugga caagagagug      720

gagcccaaga gcugcgacaa gacccacacc ugcccccccu gccccgcccc cgagcugcug      780

ggcggcccga gcguguuccu cuucccgccc aagcccaagg acacccugau gaucagccgc      840

acccccgagg ucacgugcgu gguggucgac gugagccacg aggaccccga ggugaaguuc      900

aacugguacg ucgacggggu ggaggugcac aacgccaaga ccaagccccg ggaggagcag      960

uacaacagca ccuaccgcgu cgugagcgug cugaccgucc uccaccagga cuggcugaac     1020

ggcaaggagu acaagugcaa ggugucgaac aaggcccugc cggcccccau cgagaagacg     1080

aucagcaagg cgaagggcca gcccagagag ccccaggugu acacccugcc ccccagcaga     1140

gacgagcuga ccaagaacca ggugagccug accugccugg ugaagggcuu cuaccccagc     1200

gacaucgccg uggaguggga gagcaacggc cagcccgaga acaacuacaa gaccaccccc     1260

cccgugcugg acagcgacgg cagcuucuuc cuguacagca agcugaccgu ggacaagagc     1320

agauggcagc agggcaacgu guucagcugc agcgugaugc acgaggcccu gcacaaccac     1380

uacacccaga agagccugag ccugagcccc ggcaagugag gacuaguuau aagacugacu     1440

agcccgaugg gccucccaac gggcccuccu ccccuccuug caccgagauu aauaaaaaaa     1500

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaugc     1560

aucccccccc cccccccccc cccccccccc cccaaaggcu cuuuucagag ccaccagaau     1620

u                                                                     1621


<210>  875
<211>  1564
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Ipilimumab HC without signale peptide

<400>  875
gggagaaagc uuacccaggu gcagcugguc gagagcggcg ggggcguggu gcagcccggg       60

cgcucccucc ggcugagcug cgccgccucc ggcuucaccu ucagcuccua caccaugcac      120

uggguccgcc aggcgccggg gaagggccug gaguggguga cguucaucag cuacgacggc      180

aacaacaagu acuacgccga cuccgugaag gggcgguuca ccaucagccg cgacaacucc      240

aagaacaccc ucuaccugca gaugaacagc cugcgggccg aggacaccgc caucuacuac      300

ugcgcccgca cgggcuggcu cgggcccuuc gacuacuggg gccaggggac ccuggucacc      360

guguccagcg cguccaccaa gggccccagc guguuccccc uggccccguc cagcaagucc      420

acgagcggcg ggaccgccgc ccucggcugc cuggucaagg acuacuuccc cgagcccgug      480

accguguccu ggaacagcgg ggcgcugacc agcggcgucc acacguuccc cgccgugcuc      540

caguccagcg gccuguacuc ccugagcucc guggucaccg ugccgagcuc cagccucggg      600

acccagaccu acaucugcaa cgugaaccac aagcccucca acacgaaggu cgacaagcgg      660

guggagccca agagcugcga caagacccac acgugcccgc ccugccccgc ccccgagcug      720

cugggcgggc ccuccguguu ccucuucccg cccaagccca aggacacccu gaugaucagc      780

cgcacccccg aggugaccug cgucgugguc gacguguccc acgaggaccc ggaggucaag      840

uucaacuggu acguggacgg cguggagguc cacaacgcca agaccaagcc ccgggaggag      900

caguacaaca gcaccuaccg cguggugucc guccugacgg ugcuccacca ggacuggcug      960

aacgggaagg aguacaagug caaggugagc aacaaggccc ugcccgcgcc caucgagaag     1020

accaucucca aggccaaggg ccagccgcgg gagccccagg ucuacacccu cccgcccagc     1080

cgcgacgagc ugaccaagaa ccaggugucc cugacgugcc ucgugaaggg cuucuacccc     1140

agcgacaucg ccgucgagug ggagagcaac gggcagcccg agaacaacua caagaccacg     1200

cccccggugc uggacuccga cggcagcuuc uuccuguacu ccaagcucac cguggacaag     1260

agccgguggc agcaggggaa cgucuucucc ugcagcguga ugcacgaggc ccugcacaac     1320

cacuacaccc agaagucccu gagccucucc cccggcaagu gaggacuagu uauaagacug     1380

acuagcccga ugggccuccc aacgggcccu ccuccccucc uugcaccgag auuaauaaaa     1440

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa     1500

ugcauccccc cccccccccc cccccccccc ccccccaaag gcucuuuuca gagccaccag     1560

aauu                                                                  1564


<210>  876
<211>  1564
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Ipilimumab HC without signale peptide

<400>  876
gggagaaagc uuacccaggu ccagcucguc gaguccggcg gcggcgucgu ccagcccggc       60

cgcucccucc gccucuccug cgccgccucc ggcuucaccu ucuccuccua caccaugcac      120

uggguccgcc aggcccccgg caagggccuc gaguggguca ccuucaucuc cuacgacggc      180

aacaacaagu acuacgccga cuccgucaag ggccgcuuca ccaucucccg cgacaacucc      240

aagaacaccc ucuaccucca gaugaacucc cuccgcgccg aggacaccgc caucuacuac      300

ugcgcccgca ccggcuggcu cggccccuuc gacuacuggg gccagggcac ccucgucacc      360

gucuccuccg ccuccaccaa gggccccucc gucuuccccc ucgcccccuc cuccaagucc      420

accuccggcg gcaccgccgc ccucggcugc cucgucaagg acuacuuccc cgagcccguc      480

accgucuccu ggaacuccgg cgcccucacc uccggcgucc acaccuuccc cgccguccuc      540

caguccuccg gccucuacuc ccucuccucc gucgucaccg uccccuccuc cucccucggc      600

acccagaccu acaucugcaa cgucaaccac aagcccucca acaccaaggu cgacaagcgc      660

gucgagccca aguccugcga caagacccac accugccccc ccugccccgc ccccgagcuc      720

cucggcggcc ccuccgucuu ccucuucccc cccaagccca aggacacccu caugaucucc      780

cgcacccccg aggucaccug cgucgucguc gacgucuccc acgaggaccc cgaggucaag      840

uucaacuggu acgucgacgg cgucgagguc cacaacgcca agaccaagcc ccgcgaggag      900

caguacaacu ccaccuaccg cgucgucucc guccucaccg uccuccacca ggacuggcuc      960

aacggcaagg aguacaagug caaggucucc aacaaggccc uccccgcccc caucgagaag     1020

accaucucca aggccaaggg ccagccccgc gagccccagg ucuacacccu cccccccucc     1080

cgcgacgagc ucaccaagaa ccaggucucc cucaccugcc ucgucaaggg cuucuacccc     1140

uccgacaucg ccgucgagug ggaguccaac ggccagcccg agaacaacua caagaccacc     1200

ccccccgucc ucgacuccga cggcuccuuc uuccucuacu ccaagcucac cgucgacaag     1260

ucccgcuggc agcagggcaa cgucuucucc ugcuccguca ugcacgaggc ccuccacaac     1320

cacuacaccc agaagucccu cucccucucc cccggcaagu gaggacuagu uauaagacug     1380

acuagcccga ugggccuccc aacgggcccu ccuccccucc uugcaccgag auuaauaaaa     1440

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa     1500

ugcauccccc cccccccccc cccccccccc ccccccaaag gcucuuuuca gagccaccag     1560

aauu                                                                  1564


<210>  877
<211>  1564
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Ipilimumab HC without signale peptide

<400>  877
gggagaaagc uuacccaggu gcaacugguc gagagcggcg ggggaguugu gcagcccggu       60

agaucccuca ggcuuucuug cgccgcuuca ggcuucaccu uuaguagcua cacaaugcac      120

uggguacggc aggcaccugg gaagggacug gaauggguga cuuucaucuc cuaugacggc      180

aacaauaaau acuaugccga uucugucaag ggucgcuuua cgauuucgcg agacaacagc      240

aaaaauaccu uguacuuaca gaugaacuca cugcgugcgg aggauacagc uauauauuac      300

ugugccagaa cuggguggcu aggaccauuc gacuauuggg gccaaggcac ccucgugaca      360

guuaguuccg caucuaccaa ggggccgagc guguuucccc uggccccuuc cucaaaaagu      420

acuagcggag guacagcugc acuuggcugc cuggucaagg auuacuuccc agaacccgug      480

accguaucuu ggaacuccgg ggccuugacg ucaggaguuc auacuuuucc ugcugugcuc      540

cagagcagug gccuguacuc ucuguccagc gucgugaccg ugccaucguc uucccucggu      600

acacagacuu auaucuguaa ugucaaucac aagcccucaa acaccaaagu ugacaagagg      660

guggagccua aaaguugcga uaagacacau accuguccac cgugccccgc cccugaauua      720

cuugggggac caagcguauu ccuguuuccc ccuaaaccaa aggacacguu gaugauuucc      780

cggacucccg aggugacaug ugucgugguu gaugugucuc acgaggaccc ggaagucaag      840

uucaauuggu acguggaugg cguagagguu cauaacgcga aaaccaagcc ucgcgaagaa      900

caguauaaua gcacuuacag aguggucuca gugcugacag uccuacacca agacuggcuc      960

aacggcaaag aguauaagug caaagugagu aauaaggcac ugcccgcccc aaucgagaaa     1020

accauuucca aggcuaaggg gcagccuagg gagccccagg uuuacacgcu uccacccagc     1080

cgggaugaac ugaccaaaaa ccaggugucu uugacauguc ucguaaaggg auuuuauccu     1140

ucagacaucg ccgucgagug ggaaaguaau ggucaaccag agaacaacua caaaacuacc     1200

ccgcccgugc uggacagcga uggcuccuuc uuuuuauacu cuaagcugac aguugacaaa     1260

ucgcgcuggc agcaggggaa uguguucagc ugcuccguca ugcacgaggc acuccauaac     1320

cacuauacuc aaaagucacu uagucugucu ccuggaaagu gaggacuagu uauaagacug     1380

acuagcccga ugggccuccc aacgggcccu ccuccccucc uugcaccgag auuaauaaaa     1440

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa     1500

ugcauccccc cccccccccc cccccccccc ccccccaaag gcucuuuuca gagccaccag     1560

aauu                                                                  1564


<210>  878
<211>  1564
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Ipilimumab HC without signale peptide

<400>  878
gggagaaagc uuacccaggu gcagcuggug gagagcggcg gcggcguggu gcagcccggc       60

agaagccuga gacugagcug cgccgccagc ggcuucaccu ucagcagcua caccaugcac      120

ugggugagac aggcccccgg caagggccug gaguggguga ccuucaucag cuacgacggc      180

aacaacaagu acuacgccga cagcgugaag ggcagauuca ccaucagcag agacaacagc      240

aagaacaccc uguaccugca gaugaacagc cugagagccg aggacaccgc caucuacuac      300

ugcgccagaa ccggcuggcu gggccccuuc gacuacuggg gccagggcac ccuggugacc      360

gugagcagcg ccagcaccaa gggccccagc guguuccccc uggcccccag cagcaagagc      420

accagcggcg gcaccgccgc ccugggcugc cuggugaagg acuacuuccc cgagcccgug      480

accgugagcu ggaacagcgg cgcccugacc agcggcgugc acaccuuccc cgccgugcug      540

cagagcagcg gccuguacag ccugagcagc guggugaccg ugcccagcag cagccugggc      600

acccagaccu acaucugcaa cgugaaccac aagcccagca acaccaaggu ggacaagaga      660

guggagccca agagcugcga caagacccac accugccccc ccugccccgc ccccgagcug      720

cugggcggcc ccagcguguu ccuguucccc cccaagccca aggacacccu gaugaucagc      780

agaacccccg aggugaccug cgugguggug gacgugagcc acgaggaccc cgaggugaag      840

uucaacuggu acguggacgg cguggaggug cacaacgcca agaccaagcc cagagaggag      900

caguacaaca gcaccuacag aguggugagc gugcugaccg ugcugcacca ggacuggcug      960

aacggcaagg aguacaagug caaggugagc aacaaggccc ugcccgcccc caucgagaag     1020

accaucagca aggccaaggg ccagcccaga gagccccagg uguacacccu gccccccagc     1080

agagacgagc ugaccaagaa ccaggugagc cugaccugcc uggugaaggg cuucuacccc     1140

agcgacaucg ccguggagug ggagagcaac ggccagcccg agaacaacua caagaccacc     1200

ccccccgugc uggacagcga cggcagcuuc uuccuguaca gcaagcugac cguggacaag     1260

agcagauggc agcagggcaa cguguucagc ugcagcguga ugcacgaggc ccugcacaac     1320

cacuacaccc agaagagccu gagccugagc cccggcaagu gaggacuagu uauaagacug     1380

acuagcccga ugggccuccc aacgggcccu ccuccccucc uugcaccgag auuaauaaaa     1440

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa     1500

ugcauccccc cccccccccc cccccccccc ccccccaaag gcucuuuuca gagccaccag     1560

aauu                                                                  1564


<210>  879
<211>  1564
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Ipilimumab HC without signale peptide

<400>  879
gggagaaagc uuacccaggu gcaacugguc gagagcggcg ggggaguugu gcagcccggc       60

agaucccucc ggcugucuug cgccgcuagc ggguucaccu uuuccucuua cacaaugcac      120

ugggugcgcc aggccccugg aaagggccuu gaauggguca cguucaucag cuaugacggg      180

aacaauaaau acuaugcgga uuccgugaag ggaagauuua ccauuucucg ggacaacagc      240

aaaaauacac uguaccucca gaugaacucc cugcgcgcug aggauaccgc caucuauuac      300

ugugccagaa caggcuggcu uggcccguuc gacuauuggg ggcaaggaac ccugguuaca      360

gugagcucug cuuccaccaa gggccccagc gucuuuccuc ucgcccccuc uuccaaaagc      420

acgucugggg gaaccgcugc ccugggcugc cuggugaagg auuacuuccc ugaacccguu      480

acaguguccu ggaauagcgg ggcgcucacc uccggagucc auacauuucc ugccgugcug      540

cagucuagcg gccuuuacuc ccugagcucu guggucaccg uuccguccag cucucucggc      600

acgcagacau auauuuguaa cgugaaucac aagcccagca acaccaaagu ggacaagcgg      660

gucgagccua aauccugcga uaagacacau accugucccc cuugccccgc uccggaacug      720

cuugggggac cuucuguguu ccuguuuccc ccuaaaccca aggacacccu caugaucagc      780

cgcacacccg agguuacgug uguggucgug gauguuuccc acgaggaccc ugaagugaag      840

uucaauuggu acgucgaugg cguggagguc cauaacgcca aaaccaagcc gagagaagaa      900

caguauaaua gcacauaccg ggugguuucu gugcugaccg uccugcacca agacuggcuc      960

aacgggaaag aguauaagug caaagugucc aauaaggcuc ugcccgcccc uauugagaaa     1020

acaaucagca aggcgaaggg acagccccgc gagccucagg uuuacacccu ucccccgucu     1080

agagaugaac ugacgaaaaa ccaggugucc cucacauguc uggucaaggg cuuuuauccu     1140

agcgacaucg ccguggagug ggaauccaau gggcaacccg agaacaacua caaaaccacc     1200

ccucccgugc uugacucuga uggcagcuuc uuucuguacu ccaagcucac aguugacaaa     1260

ucucgguggc agcagggaaa ugucuucagc ugcuccguga ugcacgaggc ucugcauaac     1320

cacuauaccc aaaagagccu gucucucucc ccuggcaagu gaggacuagu uauaagacug     1380

acuagcccga ugggccuccc aacgggcccu ccuccccucc uugcaccgag auuaauaaaa     1440

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa     1500

ugcauccccc cccccccccc cccccccccc ccccccaaag gcucuuuuca gagccaccag     1560

aauu                                                                  1564


<210>  880
<211>  1564
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Ipilimumab HC without signale peptide

<400>  880
gggagaaagc uuacccaagu ucaacuagua gaaucaggag gaggagucgu ccaaccaggc       60

agaucacuaa gacuaucaug ugcagccucu ggcuucacau ucucuucuua uacaaugcac      120

uggguaagac aagcaccagg aaaaggacua gaauggguaa cauucauauc uuacgacgga      180

aauaacaaau auuacgcuga uucuguaaaa gguagauuca caauuucuag agacaauagu      240

aaaaauacau uauaccucca aaugaauagu cuuagagcag aagauacagc aauauacuau      300

ugugcacgaa caggaugguu aggaccauuc gauuacuggg gucaaggaac auuaguaaca      360

guaucaucug caucaacaaa agguccuuca guauucccac ucgcaccauc aucaaaaucc      420

acaucaggag gaacugcagc ccucggaugc cuagucaaag acuacuuccc agaaccagua      480

accguaucuu ggaacuccgg agcauuaaca ucuggaguac auacauuccc ugcaguacuc      540

caaucaucag gacuauacuc acuauccucc guaguaaccg ucccuucauc aucucuaggu      600

acacaaacuu acauaugcaa cguaaaucac aaaccaucua auacaaaagu agacaaaaga      660

gucgaaccaa aaucaugcga caaaacccac acaugccccc caugcccagc acccgaacua      720

cucggaggac caucaguauu ucuauuucca ccaaaaccaa aagauacacu aaugauauca      780

cgaacaccug aaguaaccug uguugucguc gacguaucgc acgaagaccc agaaguaaaa      840

uuuaauuggu acguagacgg uguagaaguu cacaaugcaa aaacaaaacc aagagaagaa      900

caauacaacu caacauauag aguaguuucu gucuuaaccg ucuuacacca agauugguua      960

aacgguaaag aauauaaaug caaaguaucu aauaaagcuc uacccgcccc aaucgaaaaa     1020

acaauaucaa aagccaaagg ccaaccucga gaaccacaag uauacacacu acccccuuca     1080

agagaugaac uaacaaaaaa ccaaguaagc cuaacaugcc uaguaaaagg cuuuuaucca     1140

ucagacauag caguagaaug ggaaucuaac ggucaaccug aaaauaacua uaaaacaaca     1200

ccaccaguac uagacucaga uggaucauuc uuucuauacu caaaauuaac aguagauaaa     1260

ucaagauggc aacaaggaaa cguuuuuucu uguucuguaa ugcacgaagc acuacacaau     1320

cacuauaccc aaaaaucucu cagccuauca cccggaaaau gaggacuagu uauaagacug     1380

acuagcccga ugggccuccc aacgggcccu ccuccccucc uugcaccgag auuaauaaaa     1440

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa     1500

ugcauccccc cccccccccc cccccccccc ccccccaaag gcucuuuuca gagccaccag     1560

aauu                                                                  1564


<210>  881
<211>  1564
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Ipilimumab HC without signale peptide

<400>  881
gggagaaagc uuacccaggu gcaacugguc gagagcggcg gggguguggu acagcccggc       60

aggucccucc ggcugaguug cgccgcaagc ggguucaccu uuuccaguua cacuaugcac      120

ugggugcgcc aggccccagg caaggguuug gaauggguca ccuucaucag cuaugacggg      180

aacaauaaau acuaugcgga uuccgugaag ggcagguuua cgauuagccg ggacaacucc      240

aaaaauacuc uguaccucca gaugaacagu cugcgcgccg aggauaccgc aaucuauuac      300

ugugccagga ccggcugguu ggggccguuc gacuauuggg gucaaggcac ucuggugacc      360

gucagcuccg caagcacgaa ggggcccagu guguuuccac ucgcccccuc cagcaaaucc      420

accaguggcg guaccgcggc ccuggggugc cugguaaagg auuacuuccc agaacccgug      480

acugucagcu ggaacuccgg cgcacucacc agcggcgugc auaccuuucc agccgugcug      540

cagaguuccg gguuguacag ccugaguucc gucgugacgg uaccgagcag cucccucggu      600

acucagaccu auauuuguaa ugugaaucac aagcccagua acacuaaagu cgacaagcgg      660

guggagccaa aaagcugcga uaagacccau accugucccc caugccccgc cccggaacug      720

cugggcgggc ccuccguguu cuuguuucca cccaaaccaa aggacacucu caugaucagc      780

cgcacgcccg aggucaccug ugugguagug gaugucaguc acgaggaccc agaagugaaa      840

uucaauuggu acgucgaugg cguggaggug cauaacgcaa agacuaagcc gagggaagaa      900

caguauaauu ccaccuaccg gguagugagc guccugaccg ugcugcacca agacuggcuc      960

aacgguaaag aguauaagug caaagucucc aauaaggccc ugcccgcgcc aauugagaaa     1020

acuaucagua aggccaaggg ccagccccgc gagccacagg uguacacguu gcccccgagc     1080

agggaugaac ugaccaaaaa ccaggugucc cucacuuguc ugguaaaggg guuuuaucca     1140

agcgacaucg caguggagug ggaaaguaau ggccaacccg agaacaacua caaaaccacu     1200

cccccagucc uggacuccga ugggagcuuc uucuuguacu ccaagcucac uguggacaaa     1260

agucgguggc agcaggguaa ugucuuuagc ugcuccguga ugcacgaggc ccugcauaac     1320

cacuauacgc aaaagagccu gagucucucc cccggcaagu gaggacuagu uauaagacug     1380

acuagcccga ugggccuccc aacgggcccu ccuccccucc uugcaccgag auuaauaaaa     1440

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa     1500

ugcauccccc cccccccccc cccccccccc ccccccaaag gcucuuuuca gagccaccag     1560

aauu                                                                  1564


<210>  882
<211>  1564
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Ipilimumab HC without signale peptide

<400>  882
gggagaaagc uuacccaagu ccagcuagua gaauccggcg gaggcgucgu ccaaccagga       60

cgcucgcuaa gacucagcug cgccgcaucu ggcuucacau ucagcucaua cacaaugcac      120

ugggucagac aagcuccagg caaaggccuc gaauggguca cauucauauc auacgacggc      180

aacaacaaau acuacgccga cuccguaaaa ggccgcuuca ccaucuccag agacaacucc      240

aaaaacaccc uauaccucca aaugaacuca cucagagccg aagacaccgc aaucuacuac      300

ugcgcaagaa ccggcuggcu uggccccuuc gauuacuggg gacaaggcac ccucgucacc      360

gucucauccg cauccaccaa aggcccaucc gucuuccccc ucgcaccauc auccaaaucc      420

accagcggag guaccgccgc acucggcugc cuagucaaag acuacuuccc cgaaccuguc      480

acagucuccu ggaacuccgg agcccugaca ucgggcgucc acacauuccc cgccguccua      540

caaagcuccg gccucuacag ccucuccuca gucgucaccg uacccuccuc cagccucgga      600

acacaaaccu acaucugcaa cguuaaccac aaaccuucca acaccaaagu cgacaaacga      660

gucgaaccca aaucgugcga caaaacccau accugcccac ccugccccgc ccccgaacuc      720

cucggcggcc cauccgucuu ccuauuccca cccaaaccaa aggacacacu caugauauca      780

cgaaccccug aagucacgug cgucgucguc gacguuucac acgaagaccc cgaagucaaa      840

uucaacuggu acguagacgg agucgaaguc cacaacgcca aaaccaaacc ccgagaagaa      900

caauacaacu cuaccuaccg cgucguaucc guccucaccg uccuccacca agacuggcua      960

aacggcaaag aauacaagug caaaguuucg aacaaagccc uccccgcacc caucgagaaa     1020

accaucucca aagccaaagg acaaccccgc gaaccccaag uguacacccu cccacccucg     1080

cgugacgaac ucaccaaaaa ucaagucucu cuaaccugcc ucguaaaagg cuucuacccc     1140

uccgacauag caguagaaug ggaaucuaac ggccagcccg aaaacaacua caaaacaacc     1200

ccacccguac ucgacuccga cggcucauuc uuccucuacu caaaacucac cgucgauaaa     1260

ucccgcuggc aacaaggcaa ugucuucuca ugcagcguca ugcacgaagc acuccacaac     1320

cacuacacac aaaagagccu cucccuaucc cccggcaaau gaggacuagu uauaagacug     1380

acuagcccga ugggccuccc aacgggcccu ccuccccucc uugcaccgag auuaauaaaa     1440

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa     1500

ugcauccccc cccccccccc cccccccccc ccccccaaag gcucuuuuca gagccaccag     1560

aauu                                                                  1564


<210>  883
<211>  1564
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Ipilimumab HC without signale peptide

<400>  883
gggagaaagc uuacccaagu ccagcuaguc gaaucaggcg gaggcgucgu ccaacccgga       60

cggucccuac gacucagcug ugcugccagc ggcuucaccu ucucguccua cacaaugcac      120

uggguccggc aagcacccgg caaaggucuc gaauggguca ccuucauauc cuaugacggc      180

aacaacaaau acuacgccga cuccgucaaa ggccgcuuca caaucucaag agacaacucc      240

aaaaacaccc ucuaccucca aaugaacucg cuaagagcag aagacaccgc caucuacuac      300

ugcgcccgca ccggauggcu cggccccuuc gacuacuggg gccaaggcac ccuagucaca      360

guaucauccg ccucuacaaa gggaccaucc gucuuccccc ucgccccauc cuccaaaucc      420

accucuggag gcaccgccgc acucggaugc cucgucaaag acuacuuccc cgaacccguc      480

acagucuccu ggaacuccgg cgcccuaacc uccggagucc acacauuccc ugcuguccua      540

caauccucgg gccuauacuc ccucucaucu guagucaccg uccccucauc cucccuugga      600

acccaaacgu acauaugcaa cgucaaccac aaaccuucca acacaaaagu cgacaaacgu      660

guagagccaa aguccuguga caaaacacac acaugcccac caugucccgc gcccgaacua      720

cucggcggac ccucagucuu ccucuuuccc ccgaaaccca aagacacccu caugauauca      780

cgcacccccg aaguuaccug cgucgucguc gacgucuccc acgaagaccc cgaagucaaa      840

uucaacuggu acgucgacgg cguagaaguc cacaacgcca aaaccaaacc acgggaagaa      900

caauacaacu ccacauaccg cgucgucagc guacucaccg uccuacauca agacuggcua      960

aacggcaaag aauacaaaug caaaguaucc aacaaagcac ucccagcacc aaucgagaaa     1020

acaaucucaa aagcaaaagg ccaaccccgg gaaccacaag uauauacccu cccacccagc     1080

agagacgaac ucaccaaaaa ccaaguuuca cucacaugcc ucguaaaagg auucuacccc     1140

ucugacauug cugucgaaug ggaauccaac ggacaacccg aaaacaacua caaaaccacc     1200

ccgcccgucc ucgacuccga cggcucauuc uuccuauacu ccaaacucac cguagacaaa     1260

ucccgauggc agcaaggcaa cgucuucucc ugcagcguaa ugcacgaagc acuccacaac     1320

cacuauaccc aaaaaucccu cucccugucc cccggaaagu aaggacuagu uauaagacug     1380

acuagcccga ugggccuccc aacgggcccu ccuccccucc uugcaccgag auuaauaaaa     1440

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa     1500

ugcauccccc cccccccccc cccccccccc ccccccaaag gcucuuuuca gagccaccag     1560

aauu                                                                  1564


<210>  884
<211>  1564
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Ipilimumab HC without signale peptide

<400>  884
gggagaaagc uuacccaagu acaacucguc gaauccggcg gcggcguagu ccaaccaggc       60

agaucccuac gccucuccug cgccgcaucc ggauucaccu ucuccuccua caccaugcac      120

uggguacgcc aagcccccgg caagggccuc gaauggguca cguucaucuc uuacgacggc      180

aacaacaaau acuacgccga cuccguaaaa ggucguuuca ccaucucccg cgacaacagc      240

aaaaacaccc uauaccuuca aaugaacucc cuccgcgccg aagacaccgc caucuacuac      300

ugugcccgca ccgguuggcu cggccccuuc gacuacuggg gucaaggaac ccuaguuacc      360

guaucauccg caucuaccaa aggccccucc guauucccac uagccccauc guccaaauca      420

acaucaggcg gcacagccgc ccucggaugc cuagucaaag acuacuuccc cgaacccguc      480

accgucucau ggaacuccgg agcccuaacc ucgggagucc acaccuuccc agcgguacua      540

caaucauccg gacuuuacuc ccuaucaucc gucgucacag uaccauccuc aucccucggg      600

acccaaaccu acauaugcaa cgucaaccac aaaccaucca acaccaaagu cgacaaaaga      660

gucgaaccaa aauccugcga caaaacccac acaugcccac ccugcccagc ccccgaacuc      720

cucggcggcc ccuccguauu ccucuuccca cccaaaccca aggacacccu caugauaucc      780

cgcaccccag aaguaaccug cguaguaguc gacguuucac acgaagaccc cgaagucaaa      840

uucaacuggu acguagacgg cgucgagguc cacaacgcca aaaccaaacc ucgcgaagaa      900

caauacaaca gcacauaccg cgucgucucc guccuaaccg uacuacacca agacuggcua      960

aacggcaaag aauacaagug caaagucucc aacaaagccc uccccgcccc caucgagaaa     1020

accauaucca aagccaaagg ucaaccccgc gaaccccaag uauacacccu acccccaucc     1080

cgcgacgagc ucaccaaaaa ccaaguaucc cuaaccugcc ucgucaaagg cuucuacccc     1140

uccgacauag ccgucgaaug ggaaagcaau ggccagcccg aaaacaacua caaaacaacc     1200

ccacccgucc ucgacuccga cggcucuuuc uuccucuacu caaaacucac agucgacaaa     1260

ucacgauggc aacaaggcaa cgucuucucc ugcagcguaa ugcacgaagc ccuccacaac     1320

cacuacaccc aaaaaucacu cagccuaagc cccggcaagu aaggacuagu uauaagacug     1380

acuagcccga ugggccuccc aacgggcccu ccuccccucc uugcaccgag auuaauaaaa     1440

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa     1500

ugcauccccc cccccccccc cccccccccc ccccccaaag gcucuuuuca gagccaccag     1560

aauu                                                                  1564


<210>  885
<211>  1564
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Ipilimumab HC without signale peptide

<400>  885
gggagaaagc uuacccaagu ccaacuaguc gaaucaggag gaggcguagu acaaccagga       60

agauccuuaa gacuuucaug ugcagcaucu ggauuuaccu ucucaucaua cacaaugcac      120

ugggucagac aagcccccgg aaaaggacua gaauggguaa cauuuauauc auaugaugga      180

aauaacaaau auuacgcaga uucuguaaaa ggaagauuca ccaucucaag agauaauuca      240

aaaaacacac uauaccuaca aaugaacuca cucagagcug aagacaccgc aauauacuau      300

ugcgcaagaa caggaugguu aggaccuuuc gauuacuggg gacaaggaac acuaguuacc      360

gucuccuccg caaguaccaa aggaccaucu guauucccau uagcaccauc auccaaauca      420

acaucaggag gaaccgcagc auuaggaugc uuaguaaaag acuacuuucc ugaacccgua      480

acaguaucau ggaauuccgg agcacuaaca ucaggaguac auaccuuucc agcaguacuc      540

caaucaucag gauuauauuc cuuaucuuca guaguaacag ucccaucauc uucacuaggu      600

acacaaaccu acaucugcaa uguaaaccac aaaccaucaa auacaaaagu cgacaaaaga      660

guugaaccaa aaucauguga caaaacucac acaugcccac cauguccagc cccagaauua      720

cuaggaggac caucaguauu ccuuuuccca ccaaaaccaa aagauacucu aaugauaucc      780

cguaccccag aaguaacaug cgucguagua gacguaucac acgaagaccc cgaaguaaaa      840

uucaauuggu acgucgacgg aguagaagua cacaacgcca aaacaaaacc ccgagaagaa      900

caauacaacu ccacauaccg uguaguauca guauuaacag ucuuacacca agacuggcua      960

aacggaaaag aauacaaaug uaaaguuucc aacaaagcac ucccagcccc uaucgaaaaa     1020

accauaucaa aagcaaaagg ccaacccaga gaaccccaag uuuauacacu accaccauca     1080

agagacgaau uaacaaaaaa ccaaguaucc cuaacaugcc uaguaaaagg auucuacccu     1140

ucagacaucg caguagaaug ggaauccaac ggacaaccug aaaacaacua uaaaacaaca     1200

ccaccaguau uagauagcga uggaucuuuc uucuuauauu caaaacuuac aguagacaaa     1260

ucucgauggc aacaaggaaa cguauucuca ugcuccguaa ugcacgaagc gcuacauaac     1320

cauuacacac aaaaaucacu aucauuauca ccaggaaaau aaggacuagu uauaagacug     1380

acuagcccga ugggccuccc aacgggcccu ccuccccucc uugcaccgag auuaauaaaa     1440

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa     1500

ugcauccccc cccccccccc cccccccccc ccccccaaag gcucuuuuca gagccaccag     1560

aauu                                                                  1564


<210>  886
<211>  1564
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Ipilimumab HC without signale peptide

<400>  886
gggagaaagc uuacccaagu ucaauuagua gaaucuggag gaggaguagu ccaaccagga       60

cguucacuaa gacucucuug ugcagcuuca ggauuuacgu ucucaagcua uaccaugcac      120

uggguaagac aagccccagg aaaaggauua gaauggguaa cauuuauauc uuacgacggc      180

aauaacaaau auuaugcaga cucaguuaaa gguagauuca caauaagccg agacaauuca      240

aaaaacacuc uauaucuaca aaugaauagc cuaagagcag aagauacagc aauauauuac      300

ugugcacgua caggaugguu agguccuuuc gauuacuggg gacaagguac ucuaguuaca      360

guaagcagcg caucuaccaa aggaccaagc guauucccuc uugcuccauc aagcaaaucc      420

acaucaggcg gaacagcugc auuaggaugc uuaguaaaag acuauuuccc agaacccgua      480

acgguaucuu ggaacagcgg cgcauuaaca ucaggaguac auacuuuucc ugcaguacua      540

caaagcuccg gauuauacuc uuuaucauca guaguaacag uaccauccuc aucacuagga      600

acacaaacau auauauguaa cguaaaucau aaaccaucaa acaccaaagu agacaaaaga      660

guagaaccaa aaucauguga uaaaacucac accuguccuc cauguccagc acccgaauua      720

uuaggagguc caaguguauu cuuauuucca ccaaaaccua aagauacccu aaugauauca      780

agaacaccag aaguaacaug uguaguagua gacgucucac acgaagaccc agaaguaaaa      840

uucaacuggu acguagacgg aguagaagua cauaacgcua aaacuaaacc acgagaagaa      900

caauacaaua guacauacag aguaguguca guauuaacag uauuacacca agacuggcua      960

aauggaaaag aauacaaaug uaaaguauca aauaaagcac uaccagcacc aaucgaaaaa     1020

accaucucca aagccaaagg acaaccccgu gaaccucaag ucuauacccu accacccuca     1080

agagacgaac uuacaaaaaa ccaaguaagc uuaacauguc uaguaaaagg auucuaucca     1140

uccgacauag caguagaaug ggaaucaaau ggucaaccag aaaacaacua caaaacaaca     1200

ccaccaguuc ucgauucaga uggaucauuu uuucuauaua gcaaauuaac uguagacaaa     1260

ucuagauggc aacaaggaaa uguauucuca uguucaguaa ugcaugaagc acuccacaau     1320

cauuacacac aaaaaaguuu aaguuuaucc ccaggcaaau aaggacuagu uauaagacug     1380

acuagcccga ugggccuccc aacgggcccu ccuccccucc uugcaccgag auuaauaaaa     1440

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa     1500

ugcauccccc cccccccccc cccccccccc ccccccaaag gcucuuuuca gagccaccag     1560

aauu                                                                  1564


<210>  887
<211>  1564
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Ipilimumab backbone Rituximab HC without signale peptide

<400>  887
gggagaaagc uuacccaggu gcagcugguc gagagcggcg ggggcguggu gcagcccggg       60

cgcucccucc ggcugagcug cgccgccucc ggcuucaccu ucagcuccua caccaugcac      120

uggguccgcc aggcgccggg gaagggccug gaguggguga cguucaucag cuacgacggc      180

aacaacaagu acuacgccga cuccgugaag gggcgguuca ccaucagccg cgacaacucc      240

aagaacaccc ucuaccugca gaugaacagc cugcgggccg aggacaccgc caucuacuac      300

ugcgcccgca cgggcuggcu cgggcccuuc gacuacuggg gccaggggac ccuggucacc      360

guguccagcg cguccaccaa gggccccagc guguuccccc uggccccguc cagcaagucc      420

acgagcggcg ggaccgccgc ccucggcugc cuggucaagg acuacuuccc cgagcccgug      480

accguguccu ggaacagcgg ggcgcugacc agcggcgucc acacguuccc cgccgugcuc      540

caguccagcg gccuguacuc ccugagcucc guggucaccg ugccgagcuc cagccucggg      600

acccagaccu acaucugcaa cgugaaccac aagcccucca acacgaaggu cgacaagcgg      660

guggagccca agagcugcga caagacccac acgugcccgc ccugccccgc ccccgagcug      720

cugggcggcc cgagcguguu ccucuucccg cccaagccca aggacacccu gaugaucagc      780

cgcacccccg aggucacgug cguggugguc gacgugagcc acgaggaccc cgaggugaag      840

uucaacuggu acgucgacgg gguggaggug cacaacgcca agaccaagcc ccgggaggag      900

caguacaaca gcaccuaccg cgucgugagc gugcugaccg uccuccacca ggacuggcug      960

aacggcaagg aguacaagug caaggugucg aacaaggccc ugccggcccc caucgagaag     1020

acgaucagca aggcgaaggg ccagccgcgg gagccccagg ucuacacccu cccgcccagc     1080

cgcgacgagc ugaccaagaa ccaggugucc cugacgugcc ucgugaaggg cuucuacccc     1140

agcgacaucg ccgucgagug ggagagcaac gggcagcccg agaacaacua caagaccacg     1200

cccccggugc uggacuccga cggcagcuuc uuccuguacu ccaagcucac cguggacaag     1260

agccgguggc agcaggggaa cgucuucucc ugcagcguga ugcacgaggc ccugcacaac     1320

cacuacaccc agaagucccu gagccucucc cccggcaagu gaggacuagu uauaagacug     1380

acuagcccga ugggccuccc aacgggcccu ccuccccucc uugcaccgag auuaauaaaa     1440

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa     1500

ugcauccccc cccccccccc cccccccccc ccccccaaag gcucuuuuca gagccaccag     1560

aauu                                                                  1564


<210>  888
<211>  1564
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Ipilimumab backbone Rituximab HC without signale peptide

<400>  888
gggagaaagc uuacccaggu gcaacugguc gagagcggcg ggggaguugu gcagcccggu       60

agaucccuca ggcuuucuug cgccgcuuca ggcuucaccu uuaguagcua cacaaugcac      120

uggguacggc aggcaccugg gaagggacug gaauggguga cuuucaucuc cuaugacggc      180

aacaauaaau acuaugccga uucugucaag ggucgcuuua cgauuucgcg agacaacagc      240

aaaaauaccu uguacuuaca gaugaacuca cugcgugcgg aggauacagc uauauauuac      300

ugugccagaa cuggguggcu aggaccauuc gacuauuggg gccaaggcac ccucgugaca      360

guuaguuccg caucuaccaa ggggccgagc guguuucccc uggccccuuc cucaaaaagu      420

acuagcggag guacagcugc acuuggcugc cuggucaagg auuacuuccc agaacccgug      480

accguaucuu ggaacuccgg ggccuugacg ucaggaguuc auacuuuucc ugcugugcuc      540

cagagcagug gccuguacuc ucuguccagc gucgugaccg ugccaucguc uucccucggu      600

acacagacuu auaucuguaa ugucaaucac aagcccucaa acaccaaagu ugacaagagg      660

guggagccua aaaguugcga uaagacacau accuguccac cgugccccgc ccccgagcug      720

cugggcggcc cgagcguguu ccucuucccg cccaagccca aggacacccu gaugaucagc      780

cgcacccccg aggucacgug cguggugguc gacgugagcc acgaggaccc cgaggugaag      840

uucaacuggu acgucgacgg gguggaggug cacaacgcca agaccaagcc ccgggaggag      900

caguacaaca gcaccuaccg cgucgugagc gugcugaccg uccuccacca ggacuggcug      960

aacggcaagg aguacaagug caaggugucg aacaaggccc ugccggcccc caucgagaag     1020

acgaucagca aggcgaaggg gcagccuagg gagccccagg uuuacacgcu uccacccagc     1080

cgggaugaac ugaccaaaaa ccaggugucu uugacauguc ucguaaaggg auuuuauccu     1140

ucagacaucg ccgucgagug ggaaaguaau ggucaaccag agaacaacua caaaacuacc     1200

ccgcccgugc uggacagcga uggcuccuuc uuuuuauacu cuaagcugac aguugacaaa     1260

ucgcgcuggc agcaggggaa uguguucagc ugcuccguca ugcacgaggc acuccauaac     1320

cacuauacuc aaaagucacu uagucugucu ccuggaaagu gaggacuagu uauaagacug     1380

acuagcccga ugggccuccc aacgggcccu ccuccccucc uugcaccgag auuaauaaaa     1440

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa     1500

ugcauccccc cccccccccc cccccccccc ccccccaaag gcucuuuuca gagccaccag     1560

aauu                                                                  1564


<210>  889
<211>  1564
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Ipilimumab backbone Rituximab HC without signale peptide

<400>  889
gggagaaagc uuacccaggu gcagcuggug gagagcggcg gcggcguggu gcagcccggc       60

agaagccuga gacugagcug cgccgccagc ggcuucaccu ucagcagcua caccaugcac      120

ugggugagac aggcccccgg caagggccug gaguggguga ccuucaucag cuacgacggc      180

aacaacaagu acuacgccga cagcgugaag ggcagauuca ccaucagcag agacaacagc      240

aagaacaccc uguaccugca gaugaacagc cugagagccg aggacaccgc caucuacuac      300

ugcgccagaa ccggcuggcu gggccccuuc gacuacuggg gccagggcac ccuggugacc      360

gugagcagcg ccagcaccaa gggccccagc guguuccccc uggcccccag cagcaagagc      420

accagcggcg gcaccgccgc ccugggcugc cuggugaagg acuacuuccc cgagcccgug      480

accgugagcu ggaacagcgg cgcccugacc agcggcgugc acaccuuccc cgccgugcug      540

cagagcagcg gccuguacag ccugagcagc guggugaccg ugcccagcag cagccugggc      600

acccagaccu acaucugcaa cgugaaccac aagcccagca acaccaaggu ggacaagaga      660

guggagccca agagcugcga caagacccac accugccccc ccugccccgc ccccgagcug      720

cugggcggcc cgagcguguu ccucuucccg cccaagccca aggacacccu gaugaucagc      780

cgcacccccg aggucacgug cguggugguc gacgugagcc acgaggaccc cgaggugaag      840

uucaacuggu acgucgacgg gguggaggug cacaacgcca agaccaagcc ccgggaggag      900

caguacaaca gcaccuaccg cgucgugagc gugcugaccg uccuccacca ggacuggcug      960

aacggcaagg aguacaagug caaggugucg aacaaggccc ugccggcccc caucgagaag     1020

acgaucagca aggcgaaggg ccagcccaga gagccccagg uguacacccu gccccccagc     1080

agagacgagc ugaccaagaa ccaggugagc cugaccugcc uggugaaggg cuucuacccc     1140

agcgacaucg ccguggagug ggagagcaac ggccagcccg agaacaacua caagaccacc     1200

ccccccgugc uggacagcga cggcagcuuc uuccuguaca gcaagcugac cguggacaag     1260

agcagauggc agcagggcaa cguguucagc ugcagcguga ugcacgaggc ccugcacaac     1320

cacuacaccc agaagagccu gagccugagc cccggcaagu gaggacuagu uauaagacug     1380

acuagcccga ugggccuccc aacgggcccu ccuccccucc uugcaccgag auuaauaaaa     1440

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa     1500

ugcauccccc cccccccccc cccccccccc ccccccaaag gcucuuuuca gagccaccag     1560

aauu                                                                  1564


<210>  890
<211>  925
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Ipilimumab LC with signale peptide

<400>  890
gggagaaagc uuaccaugga gacccccgcc cagcugcucu uccugcugcu ccuguggcug       60

ccggacacca cgggcgagau cgugcugacc cagagccccg gcacccucuc ccugagcccg      120

ggggagcgcg ccacgcuguc cugccgggcc agccaguccg ucggcagcuc cuaccucgcg      180

ugguaccagc agaagcccgg gcaggcgccc cgccugcuga ucuacggcgc cuucagccgg      240

gccaccggga uccccgaccg cuucuccggc agcggcuccg ggaccgacuu cacccucacg      300

aucagccggc uggagccgga ggacuucgcc guguacuacu gccagcagua cggcuccagc      360

cccuggaccu ucgggcaggg caccaaggug gagaucaagc gcaccgucgc cgcccccucc      420

guguucaucu ucccgcccag cgacgagcag cugaaguccg ggacggccag cguggucugc      480

cuccugaaca acuucuaccc ccgggaggcc aaggugcagu ggaaggugga caacgcgcug      540

caguccggca acagccagga gagcgucacc gagcaggacu ccaaggacag caccuacucc      600

cucagcucca cccugacgcu gagcaaggcc gacuacgaga agcacaaggu guacgccugc      660

gaggugaccc accagggccu cuccagcccc gucaccaagu ccuucaaccg cggggagugc      720

ugaggacuag uuauaagacu gacuagcccg augggccucc caacgggccc uccuccccuc      780

cuugcaccga gauuaauaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa      840

aaaaaaaaaa aaaaaaaaaa augcaucccc cccccccccc cccccccccc cccccccaaa      900

ggcucuuuuc agagccacca gaauu                                            925


<210>  891
<211>  925
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Ipilimumab LC with signale peptide

<400>  891
gggagaaagc uuaccaugga gacccccgcc cagcuccucu uccuccuccu ccucuggcuc       60

cccgacacca ccggcgagau cguccucacc cagucccccg gcacccucuc ccucuccccc      120

ggcgagcgcg ccacccucuc cugccgcgcc ucccaguccg ucggcuccuc cuaccucgcc      180

ugguaccagc agaagcccgg ccaggccccc cgccuccuca ucuacggcgc cuucucccgc      240

gccaccggca uccccgaccg cuucuccggc uccggcuccg gcaccgacuu cacccucacc      300

aucucccgcc ucgagcccga ggacuucgcc gucuacuacu gccagcagua cggcuccucc      360

cccuggaccu ucggccaggg caccaagguc gagaucaagc gcaccgucgc cgcccccucc      420

gucuucaucu ucccccccuc cgacgagcag cucaaguccg gcaccgccuc cgucgucugc      480

cuccucaaca acuucuaccc ccgcgaggcc aagguccagu ggaaggucga caacgcccuc      540

caguccggca acucccagga guccgucacc gagcaggacu ccaaggacuc caccuacucc      600

cucuccucca cccucacccu cuccaaggcc gacuacgaga agcacaaggu cuacgccugc      660

gaggucaccc accagggccu cuccuccccc gucaccaagu ccuucaaccg cggcgagugc      720

ugaggacuag uuauaagacu gacuagcccg augggccucc caacgggccc uccuccccuc      780

cuugcaccga gauuaauaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa      840

aaaaaaaaaa aaaaaaaaaa augcaucccc cccccccccc cccccccccc cccccccaaa      900

ggcucuuuuc agagccacca gaauu                                            925


<210>  892
<211>  925
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Ipilimumab LC with signale peptide

<400>  892
gggagaaagc uuaccaugga gacccccgcc cagcuucucu uccuucuguu guuauggcug       60

ccugacacaa cuggcgaaau cgugcuaacg caaagcccag ggacccucuc ccugucuccg      120

ggagagagag cuacacuuuc augcagggca agucagagcg ucgguuccuc uuaccuggcc      180

ugguaucagc agaagcccgg ccaagcgccu cgguugcuca uuuacggggc uuuuucgcgc      240

gccacuggaa uaccagaucg auucucaggc agcgguagug ggaccgacuu uacacugacc      300

aucucccguc uggaacccga ggauuucgca guuuauuacu gucagcagua uggaucuagc      360

ccuuggacuu uuggccaggg cacaaaagug gaaauuaaga gaaccguagc cgcuccaucc      420

guguucaucu uucccccuuc agacgagcaa cucaaaagug ggacggcaag cgucgugugc      480

uuacugaaca auuucuaccc aagggaggcc aagguucagu ggaaagugga uaacgcucug      540

cagucuggaa auucccagga aucagucacu gagcaagaca gcaaggauag uaccuauucu      600

uuguccagca cacugacucu aucgaaggcc gacuacgaaa aacacaaggu guacgcgugu      660

gagguaaccc aucagggucu cucuuccccg guuacaaaau cauuuaaccg gggcgagugc      720

ugaggacuag uuauaagacu gacuagcccg augggccucc caacgggccc uccuccccuc      780

cuugcaccga gauuaauaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa      840

aaaaaaaaaa aaaaaaaaaa augcaucccc cccccccccc cccccccccc cccccccaaa      900

ggcucuuuuc agagccacca gaauu                                            925


<210>  893
<211>  925
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Ipilimumab LC with signale peptide

<400>  893
gggagaaagc uuaccaugga gacccccgcc cagcugcugu uccugcugcu gcuguggcug       60

cccgacacca ccggcgagau cgugcugacc cagagccccg gcacccugag ccugagcccc      120

ggcgagagag ccacccugag cugcagagcc agccagagcg ugggcagcag cuaccuggcc      180

ugguaccagc agaagcccgg ccaggccccc agacugcuga ucuacggcgc cuucagcaga      240

gccaccggca uccccgacag auucagcggc agcggcagcg gcaccgacuu cacccugacc      300

aucagcagac uggagcccga ggacuucgcc guguacuacu gccagcagua cggcagcagc      360

cccuggaccu ucggccaggg caccaaggug gagaucaaga gaaccguggc cgcccccagc      420

guguucaucu ucccccccag cgacgagcag cugaagagcg gcaccgccag cguggugugc      480

cugcugaaca acuucuaccc cagagaggcc aaggugcagu ggaaggugga caacgcccug      540

cagagcggca acagccagga gagcgugacc gagcaggaca gcaaggacag caccuacagc      600

cugagcagca cccugacccu gagcaaggcc gacuacgaga agcacaaggu guacgccugc      660

gaggugaccc accagggccu gagcagcccc gugaccaaga gcuucaacag aggcgagugc      720

ugaggacuag uuauaagacu gacuagcccg augggccucc caacgggccc uccuccccuc      780

cuugcaccga gauuaauaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa      840

aaaaaaaaaa aaaaaaaaaa augcaucccc cccccccccc cccccccccc cccccccaaa      900

ggcucuuuuc agagccacca gaauu                                            925


<210>  894
<211>  925
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Ipilimumab LC with signale peptide

<400>  894
gggagaaagc uuaccaugga gacccccgcc cagcuccugu uccugcuucu gcucuggcug       60

ccugacacaa cgggcgaaau cgugcuuacc caaagcccgg ggacacuguc ccucucuccc      120

ggagagagag cuacccugag cugccgggcc ucccagucug ucggcagcuc cuaccuggcg      180

ugguaucagc agaaaccugg gcaagcuccc cgccuccuga uuuacggagc cuuuucuaga      240

gccacaggca ucccugaucg guucagcggg uccggaagcg gcaccgacuu uacacuuacc      300

auuucucgcc uggaacccga ggauuucgcu guuuauuacu gucagcagua uggcuccagc      360

ccuuggacgu uugggcaggg aaccaaagug gaaaucaaga gaacaguggc cgcuccgucu      420

gucuucauuu uucccccuuc cgacgagcaa cucaaaagcg gcaccgccuc ugugguuugc      480

cugcuuaaca auuucuaccc ccgggaggcg aaggugcagu ggaaagucga uaacgcccug      540

caguccggga auagccagga auccgugaca gagcaagacu cuaaggauag caccuauucc      600

cucagcucua cgcugacacu guccaaggcu gacuacgaaa aacacaaggu uuacgccugu      660

gaggugaccc aucagggacu cagcucuccu gucacaaaga gcuuuaaccg cggcgagugc      720

ugaggacuag uuauaagacu gacuagcccg augggccucc caacgggccc uccuccccuc      780

cuugcaccga gauuaauaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa      840

aaaaaaaaaa aaaaaaaaaa augcaucccc cccccccccc cccccccccc cccccccaaa      900

ggcucuuuuc agagccacca gaauu                                            925


<210>  895
<211>  925
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Ipilimumab LC with signale peptide

<400>  895
gggagaaagc uuaccaugga aacaccagca caacuacuau ucuuacuauu acuauggcua       60

ccagacacaa caggagaaau aguacuaaca caaucaccag gaacacuaag ucuaucacca      120

ggagaaagag caacacuauc augcagagca ucccaaucag uuggaucuuc cuaccuagcc      180

ugguaucaac aaaaaccagg acaagcacca agauuacuaa uauacggagc auucucaaga      240

gcaacuggaa ucccagauag auucucagga ucaggaucag gaacagacuu cacauuaaca      300

auaucacgac uagaaccaga agacuucgca guauacuacu gucaacaaua cggauccuca      360

ccauggaccu ucggccaagg aacaaaagua gaaauaaaaa gaacaguagc agccccaucu      420

guauucauau ucccaccauc agaugaacaa cuaaaaucag gaacagcauc aguaguaugc      480

uuacuaaaca acuucuaccc aagagaagcc aaaguacaau ggaaaguaga caacgcacua      540

caaucaggaa auucccaaga aucaguaaca gaacaagacu caaaagacuc cacauacuca      600

uuaucaucaa cauuaacacu aucaaaagca gacuacgaaa aacacaaagu auacgcaugu      660

gaaguaacac accaaggacu aucaucacca guaacaaaau cauucaaccg aggagaaugc      720

ugaggacuag uuauaagacu gacuagcccg augggccucc caacgggccc uccuccccuc      780

cuugcaccga gauuaauaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa      840

aaaaaaaaaa aaaaaaaaaa augcaucccc cccccccccc cccccccccc cccccccaaa      900

ggcucuuuuc agagccacca gaauu                                            925


<210>  896
<211>  925
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Ipilimumab LC with signale peptide

<400>  896
gggagaaagc uuaccaugga gacccccgcc cagcuccugu uccuguugcu gcucuggcug       60

ccagacacua ccggcgaaau cguguugacg caaagcccgg ggacucuguc ccucaguccc      120

ggugagaggg caacccugag cugccgggcc ucccagagug ucggcagcuc cuaccuggcg      180

ugguaucagc agaagccagg gcaagcaccc cgccuccuga uuuacggcgc cuuuagcagg      240

gccaccggua ucccagaucg guucuccggg aguggcagcg gcacugacuu uaccuugacg      300

auuucccgcc uggaacccga ggauuucgca guguauuacu gucagcagua ugggagcagu      360

ccauggacuu uuggucaggg caccaaagua gaaaucaaga ggacuguggc cgcgccgucc      420

gucuucauuu uucccccaag cgacgagcaa cucaaauccg ggaccgccag uguggugugc      480

cugcugaaca auuucuaccc ccgggaggca aagguccagu ggaaagugga uaacgccuug      540

cagagcggca auucccagga aagcguaacc gagcaagaca guaaggauuc cacguauagc      600

cucaguucca cucugacccu gagcaaggcc gacuacgaaa aacacaaggu guacgcaugu      660

gaggucacuc aucagggucu cagcucccca gugaccaaaa guuuuaaccg cggggagugc      720

ugaggacuag uuauaagacu gacuagcccg augggccucc caacgggccc uccuccccuc      780

cuugcaccga gauuaauaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa      840

aaaaaaaaaa aaaaaaaaaa augcaucccc cccccccccc cccccccccc cccccccaaa      900

ggcucuuuuc agagccacca gaauu                                            925


<210>  897
<211>  925
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Ipilimumab LC with signale peptide

<400>  897
gggagaaagc uuaccaugga aacccccgcc caacuccucu uccuauuacu ccucuggcua       60

cccgacacca ccggcgaaau cguccucacc caauccccag gcacccucuc ucucuccccc      120

ggagaacgcg caacacucuc cugccgugca ucccaauccg ucggaucuuc cuaccucgcc      180

ugguaccaac aaaaacccgg ccaagcccca cgccuccuca ucuacggcgc cuucucccgc      240

gccaccggca uuccagaccg uuucucagga uccggcuccg gcaccgauuu cacacucacc      300

aucucccgcc uagaaccaga agacuucgcc guauacuacu gccagcaaua cggaucuucc      360

cccuggacau ucggccaagg caccaaaguc gaaaucaaac gcaccgucgc agcccccucc      420

gucuucaucu ucccacccuc cgacgaacaa cuaaaaucug gcacagcauc cgucgucugc      480

cuccuaaaca acuucuaccc ccgcgaagcc aaaguccaau ggaaagucga caacgcacuc      540

caaucuggca acucacaaga auccgucaca gaacaagacu ccaaagacuc aaccuacucc      600

cucuccucaa cccucacccu cuccaaagcc gacuacgaaa aacacaaggu cuacgcaugc      660

gaagucaccc aucaaggacu cuccuccccc gucaccaaau ccuucaaccg cggcgaaugc      720

uaaggacuag uuauaagacu gacuagcccg augggccucc caacgggccc uccuccccuc      780

cuugcaccga gauuaauaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa      840

aaaaaaaaaa aaaaaaaaaa augcaucccc cccccccccc cccccccccc cccccccaaa      900

ggcucuuuuc agagccacca gaauu                                            925


<210>  898
<211>  925
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Ipilimumab LC with signale peptide

<400>  898
gggagaaagc uuaccaugga aacacccgcc caacuccucu uccuccuccu ccucuggcua       60

cccgacacca ccggcgaaau cguccucacc caaucccccg gcacccuauc ccucuccccc      120

ggcgaacgcg ccacccuauc cugccgcgca ucccaauccg uaggauccuc cuaccucgcc      180

ugguaccaac aaaaacccgg ccaagcaccc cgccuccuca ucuacggagc cuucucccgc      240

gccaccggca ucccugaccg cuucuccggc ucaggcucag gcaccgacuu cacccucacc      300

aucucucgcc uagaacccga agacuucgcc guauacuauu gccaacaaua cggcuccucc      360

ccuuggaccu ucggccaagg aacaaaaguc gaaaucaaac gaaccgucgc cgcccccuca      420

gucuucaucu ucccacccuc cgacgaacaa cucaaauccg guaccgccuc cgucgucugc      480

cuucucaaca acuucuaccc ccgagaagcc aaaguacaau ggaaagucga caacgcacua      540

caaucaggca acucccaaga auccgucacc gaacaagauu ccaaagacuc aaccuacuca      600

cucuccucca cacucacccu cuccaaagcc gacuacgaaa aacacaaagu cuacgccugc      660

gaagucaccc accaaggacu cuccagcccc gucaccaaau ccuucaaccg cggcgaaugc      720

uaaggacuag uuauaagacu gacuagcccg augggccucc caacgggccc uccuccccuc      780

cuugcaccga gauuaauaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa      840

aaaaaaaaaa aaaaaaaaaa augcaucccc cccccccccc cccccccccc cccccccaaa      900

ggcucuuuuc agagccacca gaauu                                            925


<210>  899
<211>  925
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Ipilimumab LC with signale peptide

<400>  899
gggagaaagc uuaccaugga aacucccgcc caacuacucu uccuccuccu ccucuggcuc       60

cccgacacca ccggcgaaau cguccuuacc cagucccccg gcacccucuc acucuccccc      120

ggcgaacgcg ccacccuauc cugucgcgcc ucccaaucag ucggcucauc auaccucgcc      180

ugguaccaac aaaaacccgg ccaagccccu cgccuccuca uauacggcgc cuucucccgc      240

gccaccggca uccccgaccg auucuccggc uccggcuccg gcacugacuu cacccucacc      300

auaucccgcc ucgaacccga agacuucgca gucuacuacu gccaacaaua cggaucuucc      360

cccuggaccu ucggccaagg caccaaaguc gaaaucaaac gcaccgucgc cgcccccucc      420

gucuucauau ucccacccuc agacgaacaa cucaaaucag gcaccgcauc cgucgucugc      480

cuccucaaca acuucuaccc ccgcgaagcc aaaguccaau ggaaagucga caacgcccuc      540

caaucaggca acucacaaga auccgucaca gaacaagacu ccaaagacuc aaccuacucc      600

cucuccucaa cccucacacu cuccaaagcc gacuacgaaa aacacaaagu cuacgccugc      660

gaagucaccc accaaggacu uuccucaccc gucaccaaau ccuucaaccg cggcgaaugc      720

uaaggacuag uuauaagacu gacuagcccg augggccucc caacgggccc uccuccccuc      780

cuugcaccga gauuaauaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa      840

aaaaaaaaaa aaaaaaaaaa augcaucccc cccccccccc cccccccccc cccccccaaa      900

ggcucuuuuc agagccacca gaauu                                            925


<210>  900
<211>  925
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Ipilimumab LC with signale peptide

<400>  900
gggagaaagc uuaccaugga aacaccagca caacuauuau uccuauuacu ucuauggcua       60

ccagacacaa caggagaaau aguauuaaca caaagcccag gaacacucuc auuaucacca      120

ggagaaagag caacacucuc augccgagca ucccaauccg ucggaucauc auaucuagca      180

ugguaccaac aaaaaccagg acaagcaccc agacuacuaa uauacggagc auuuucaaga      240

gccacaggaa ucccagacag auuuucagga ucaggaucag gaacagacuu cacauuaaca      300

auaucacgau uagaacccga agacuucgca guauacuacu gccaacaaua cggaucaucu      360

cccuggacau ucggacaagg cacaaaagua gaaauaaaac gaacagucgc agcaccauca      420

guauucauau ucccaccauc agacgaacaa cuaaaaucag gaacagcauc aguaguaugc      480

cuauuaaaua acuucuaccc aagagaagca aaaguccaau ggaaaguaga uaacgcacua      540

caaucaggaa acucucaaga aucaguaacc gaacaagacu caaaagauuc aaccuacuca      600

uuaucaucaa cauuaacacu aucaaaagca gacuacgaaa aacacaaagu auacgcaugc      660

gaaguaaccc accaaggccu aucaucacca guaacaaaau cauucaacag aggagaaugc      720

ugaggacuag uuauaagacu gacuagcccg augggccucc caacgggccc uccuccccuc      780

cuugcaccga gauuaauaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa      840

aaaaaaaaaa aaaaaaaaaa augcaucccc cccccccccc cccccccccc cccccccaaa      900

ggcucuuuuc agagccacca gaauu                                            925


<210>  901
<211>  925
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Ipilimumab LC with signale peptide

<400>  901
gggagaaagc uuaccaugga aaccccugcc caauuacuau ucuuauuauu acucuggcua       60

ccagacacaa caggagaaau aguuuuaaca caaucaccag gcacacuauc acuaucacca      120

ggagaaagag caacacuauc augcagagcc ucacaaucag ucggaucauc auaccuagca      180

ugguaucaac aaaaacccgg acaagcacca agauuauuaa uauauggagc auucucacga      240

gcaaccggaa uaccagauag auucucagga ucaggaagcg gcaccgacuu cacauuaaca      300

auaucuagac uagaaccaga agauuucgca guauacuacu gccaacaaua uggaucuuca      360

ccauggacau ucggacaagg aacaaaaguu gaaauaaaaa gaacaguagc agcaccauca      420

guauucauau ucccaccauc agacgaacaa uuaaaaucag gaacagccuc uguaguaugc      480

cuauuaaaca acuuuuaccc aagagaagca aaaguucaau ggaaaguaga caaugcacua      540

caaucaggca acucacaaga aucaguaaca gaacaagacu cuaaagacuc aacauauagc      600

cuaucaucaa cacucacccu aucaaaagca gacuacgaaa aacacaaagu auacgcaugu      660

gaaguaacac accaaggacu aucaucacca guaacaaaau cauucaacag aggagaaugc      720

uaaggacuag uuauaagacu gacuagcccg augggccucc caacgggccc uccuccccuc      780

cuugcaccga gauuaauaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa      840

aaaaaaaaaa aaaaaaaaaa augcaucccc cccccccccc cccccccccc cccccccaaa      900

ggcucuuuuc agagccacca gaauu                                            925


<210>  902
<211>  925
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Ipilimumab backbone Rituximab LC with signale peptide

<400>  902
gggagaaagc uuaccaugga gacccccgcc cagcugcucu uccugcugcu ccuguggcug       60

ccggacacca cgggcgagau cgugcugacc cagagccccg gcacccucuc ccugagcccg      120

ggggagcgcg ccacgcuguc cugccgggcc agccaguccg ucggcagcuc cuaccucgcg      180

ugguaccagc agaagcccgg gcaggcgccc cgccugcuga ucuacggcgc cuucagccgg      240

gccaccggga uccccgaccg cuucuccggc agcggcuccg ggaccgacuu cacccucacg      300

aucagccggc uggagccgga ggacuucgcc guguacuacu gccagcagua cggcuccagc      360

cccuggaccu ucgggcaggg caccaaggug gagaucaagc gcaccguggc ggcccccagc      420

guguucaucu ucccgcccag cgacgagcag cugaagagcg ggaccgccuc ggucgugugc      480

cuccugaaca acuucuaccc ccgggaggcc aaggugcagu ggaaggucga caacgcgcug      540

cagagcggca acagccagga gagcgugacg gagcaggaca gcaaggacag caccuacucg      600

cucagcagca cccugacccu gagcaaggcc gacuacgaga agcacaaggu guacgccugc      660

gaggucacgc accaggggcu cagcucgccc gugaccaaga gcuucaaccg cggggagugc      720

ugaggacuag uuauaagacu gacuagcccg augggccucc caacgggccc uccuccccuc      780

cuugcaccga gauuaauaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa      840

aaaaaaaaaa aaaaaaaaaa augcaucccc cccccccccc cccccccccc cccccccaaa      900

ggcucuuuuc agagccacca gaauu                                            925


<210>  903
<211>  925
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Ipilimumab backbone Rituximab LC with signale peptide

<400>  903
gggagaaagc uuaccaugga gacccccgcc cagcuucucu uccuucuguu guuauggcug       60

ccugacacaa cuggcgaaau cgugcuaacg caaagcccag ggacccucuc ccugucuccg      120

ggagagagag cuacacuuuc augcagggca agucagagcg ucgguuccuc uuaccuggcc      180

ugguaucagc agaagcccgg ccaagcgccu cgguugcuca uuuacggggc uuuuucgcgc      240

gccacuggaa uaccagaucg auucucaggc agcgguagug ggaccgacuu uacacugacc      300

aucucccguc uggaacccga ggauuucgca guuuauuacu gucagcagua uggaucuagc      360

ccuuggacuu uuggccaggg cacaaaagug gaaauuaaga gaaccguggc ggcccccagc      420

guguucaucu ucccgcccag cgacgagcag cugaagagcg ggaccgccuc ggucgugugc      480

cuccugaaca acuucuaccc ccgggaggcc aaggugcagu ggaaggucga caacgcgcug      540

cagagcggca acagccagga gagcgugacg gagcaggaca gcaaggacag caccuacucg      600

cucagcagca cccugacccu gagcaaggcc gacuacgaga agcacaaggu guacgccugc      660

gaggucacgc accaggggcu cagcucgccc gugaccaaga gcuucaaccg cggcgagugc      720

ugaggacuag uuauaagacu gacuagcccg augggccucc caacgggccc uccuccccuc      780

cuugcaccga gauuaauaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa      840

aaaaaaaaaa aaaaaaaaaa augcaucccc cccccccccc cccccccccc cccccccaaa      900

ggcucuuuuc agagccacca gaauu                                            925


<210>  904
<211>  925
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Ipilimumab backbone Rituximab LC with signale peptide

<400>  904
gggagaaagc uuaccaugga gacccccgcc cagcugcugu uccugcugcu gcuguggcug       60

cccgacacca ccggcgagau cgugcugacc cagagccccg gcacccugag ccugagcccc      120

ggcgagagag ccacccugag cugcagagcc agccagagcg ugggcagcag cuaccuggcc      180

ugguaccagc agaagcccgg ccaggccccc agacugcuga ucuacggcgc cuucagcaga      240

gccaccggca uccccgacag auucagcggc agcggcagcg gcaccgacuu cacccugacc      300

aucagcagac uggagcccga ggacuucgcc guguacuacu gccagcagua cggcagcagc      360

cccuggaccu ucggccaggg caccaaggug gagaucaaga gaaccguggc ggcccccagc      420

guguucaucu ucccgcccag cgacgagcag cugaagagcg ggaccgccuc ggucgugugc      480

cuccugaaca acuucuaccc ccgggaggcc aaggugcagu ggaaggucga caacgcgcug      540

cagagcggca acagccagga gagcgugacg gagcaggaca gcaaggacag caccuacucg      600

cucagcagca cccugacccu gagcaaggcc gacuacgaga agcacaaggu guacgccugc      660

gaggucacgc accaggggcu cagcucgccc gugaccaaga gcuucaaccg cggcgagugc      720

ugaggacuag uuauaagacu gacuagcccg augggccucc caacgggccc uccuccccuc      780

cuugcaccga gauuaauaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa      840

aaaaaaaaaa aaaaaaaaaa augcaucccc cccccccccc cccccccccc cccccccaaa      900

ggcucuuuuc agagccacca gaauu                                            925


<210>  905
<211>  865
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Ipilimumab LC without signale peptide

<400>  905
gggagaaagc uuaccgagau cgugcugacc cagagccccg gcacccucuc ccugagcccg       60

ggggagcgcg ccacgcuguc cugccgggcc agccaguccg ucggcagcuc cuaccucgcg      120

ugguaccagc agaagcccgg gcaggcgccc cgccugcuga ucuacggcgc cuucagccgg      180

gccaccggga uccccgaccg cuucuccggc agcggcuccg ggaccgacuu cacccucacg      240

aucagccggc uggagccgga ggacuucgcc guguacuacu gccagcagua cggcuccagc      300

cccuggaccu ucgggcaggg caccaaggug gagaucaagc gcaccgucgc cgcccccucc      360

guguucaucu ucccgcccag cgacgagcag cugaaguccg ggacggccag cguggucugc      420

cuccugaaca acuucuaccc ccgggaggcc aaggugcagu ggaaggugga caacgcgcug      480

caguccggca acagccagga gagcgucacc gagcaggacu ccaaggacag caccuacucc      540

cucagcucca cccugacgcu gagcaaggcc gacuacgaga agcacaaggu guacgccugc      600

gaggugaccc accagggccu cuccagcccc gucaccaagu ccuucaaccg cggggagugc      660

ugaggacuag uuauaagacu gacuagcccg augggccucc caacgggccc uccuccccuc      720

cuugcaccga gauuaauaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa      780

aaaaaaaaaa aaaaaaaaaa augcaucccc cccccccccc cccccccccc cccccccaaa      840

ggcucuuuuc agagccacca gaauu                                            865


<210>  906
<211>  865
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Ipilimumab LC without signale peptide

<400>  906
gggagaaagc uuaccgagau cguccucacc cagucccccg gcacccucuc ccucuccccc       60

ggcgagcgcg ccacccucuc cugccgcgcc ucccaguccg ucggcuccuc cuaccucgcc      120

ugguaccagc agaagcccgg ccaggccccc cgccuccuca ucuacggcgc cuucucccgc      180

gccaccggca uccccgaccg cuucuccggc uccggcuccg gcaccgacuu cacccucacc      240

aucucccgcc ucgagcccga ggacuucgcc gucuacuacu gccagcagua cggcuccucc      300

cccuggaccu ucggccaggg caccaagguc gagaucaagc gcaccgucgc cgcccccucc      360

gucuucaucu ucccccccuc cgacgagcag cucaaguccg gcaccgccuc cgucgucugc      420

cuccucaaca acuucuaccc ccgcgaggcc aagguccagu ggaaggucga caacgcccuc      480

caguccggca acucccagga guccgucacc gagcaggacu ccaaggacuc caccuacucc      540

cucuccucca cccucacccu cuccaaggcc gacuacgaga agcacaaggu cuacgccugc      600

gaggucaccc accagggccu cuccuccccc gucaccaagu ccuucaaccg cggcgagugc      660

ugaggacuag uuauaagacu gacuagcccg augggccucc caacgggccc uccuccccuc      720

cuugcaccga gauuaauaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa      780

aaaaaaaaaa aaaaaaaaaa augcaucccc cccccccccc cccccccccc cccccccaaa      840

ggcucuuuuc agagccacca gaauu                                            865


<210>  907
<211>  865
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Ipilimumab LC without signale peptide

<400>  907
gggagaaagc uuaccgagau cgugcugacc cagagccccg gcacacucuc ccuuucuccu       60

ggggaaagag ccacucuguc augcagggcu agucaaagcg ucggauccuc uuacuuggca      120

ugguaucagc agaagccagg ucaggccccg cgguuacuga uuuacggcgc guucucgcgc      180

gcuacgggga uacccgaccg auuuucagga agcggcagug guaccgauuu cacacuaacu      240

aucucccguc ucgagccuga agacuuugcc guuuauuacu gucaacagua ugggucuagc      300

ccauggaccu ucggacaggg cacaaaagug gagauuaaga gaaccguagc agcccccucc      360

guguuuaucu ucccuccauc agaugaacag cugaaaagug gcacugcuag cgucgugugc      420

cuucugaaca auuuuuaccc cagggaggca aagguucaau ggaaagugga caacgccuug      480

cagucuggaa auucccagga gucagucaca gaacaggaua gcaaggacag uaccuauucu      540

cucuccagca cgcugacucu gucgaaggcu gauuacgaga aacacaaggu guacgccugu      600

gaaguaaccc aucaagggcu cucuuccccu guuacaaaau cauucaaccg gggugagugc      660

ugaggacuag uuauaagacu gacuagcccg augggccucc caacgggccc uccuccccuc      720

cuugcaccga gauuaauaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa      780

aaaaaaaaaa aaaaaaaaaa augcaucccc cccccccccc cccccccccc cccccccaaa      840

ggcucuuuuc agagccacca gaauu                                            865


<210>  908
<211>  865
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Ipilimumab LC without signale peptide

<400>  908
gggagaaagc uuaccgagau cgugcugacc cagagccccg gcacccugag ccugagcccc       60

ggcgagagag ccacccugag cugcagagcc agccagagcg ugggcagcag cuaccuggcc      120

ugguaccagc agaagcccgg ccaggccccc agacugcuga ucuacggcgc cuucagcaga      180

gccaccggca uccccgacag auucagcggc agcggcagcg gcaccgacuu cacccugacc      240

aucagcagac uggagcccga ggacuucgcc guguacuacu gccagcagua cggcagcagc      300

cccuggaccu ucggccaggg caccaaggug gagaucaaga gaaccguggc cgcccccagc      360

guguucaucu ucccccccag cgacgagcag cugaagagcg gcaccgccag cguggugugc      420

cugcugaaca acuucuaccc cagagaggcc aaggugcagu ggaaggugga caacgcccug      480

cagagcggca acagccagga gagcgugacc gagcaggaca gcaaggacag caccuacagc      540

cugagcagca cccugacccu gagcaaggcc gacuacgaga agcacaaggu guacgccugc      600

gaggugaccc accagggccu gagcagcccc gugaccaaga gcuucaacag aggcgagugc      660

ugaggacuag uuauaagacu gacuagcccg augggccucc caacgggccc uccuccccuc      720

cuugcaccga gauuaauaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa      780

aaaaaaaaaa aaaaaaaaaa augcaucccc cccccccccc cccccccccc cccccccaaa      840

ggcucuuuuc agagccacca gaauu                                            865


<210>  909
<211>  865
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Ipilimumab LC without signale peptide

<400>  909
gggagaaagc uuaccgagau cgugcugacc cagagccccg gcacacucag ccugucuccu       60

ggggaaagag ccacgcuuag cugccgggcu ucccaaucug ucggaagcuc cuaccuggcc      120

ugguaucagc agaagccggg ccaggcgccc cgccuccuga uuuacggggc uuucucuaga      180

gccaccggaa ucccugaccg guuuagcggc uccgggagcg gaacagauuu cacccuuaca      240

auuucucgcc uggagcccga agacuuugcc guuuauuacu gucaacagua uggcuccagc      300

ccuuggaccu ucggccaggg gacaaaagug gagaucaaga gaaccguggc ugcccccucu      360

gucuuuauuu ucccuccguc cgaugaacag cucaaaagcg gaacggcuuc ugugguuugc      420

cugcugaaca auuuuuaccc ccgggaggcc aaggugcaau ggaaagucga caacgcgcuc      480

caguccggca auagccagga guccgugacc gaacaggauu cuaaggacag cacauauucc      540

cugagcucua cccuuacacu guccaaggcc gauuacgaga aacacaaggu uuacgcuugu      600

gaagugaccc aucaagggcu cagcucuccu gucacgaaau ccuucaaccg cggagagugc      660

ugaggacuag uuauaagacu gacuagcccg augggccucc caacgggccc uccuccccuc      720

cuugcaccga gauuaauaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa      780

aaaaaaaaaa aaaaaaaaaa augcaucccc cccccccccc cccccccccc cccccccaaa      840

ggcucuuuuc agagccacca gaauu                                            865


<210>  910
<211>  865
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Ipilimumab LC without signale peptide

<400>  910
gggagaaagc uuaccgaaau aguacuaaca caaucaccag gaacccucuc acuaucucca       60

ggagaaagag caacacuaag cugcagagcc ucacaaucag ucggaucauc auaccuagca      120

ugguaccaac aaaaaccagg acaagccccc agauuacuaa ucuacggagc auucucacga      180

gcaacaggaa ucccagacag auucucaggu uccggaucag gaacagacuu cacacuaaca      240

auauccagau uagaaccaga agacuucgca guauacuacu gccaacaaua cggaucauca      300

ccauggacau uuggacaagg aaccaaagua gaaaucaaaa gaacaguagc agccccauca      360

guauuuauau ucccaccauc agacgaacaa cuaaaaucag gcaccgcauc aguaguaugu      420

cuauuaaaca acuucuaccc aagagaagca aaaguacaau ggaaaguaga caacgcacua      480

caaucaggaa acucccaaga aucagucaca gaacaagacu caaaagacuc aacauacuca      540

cuaucaucaa cacuaaccuu aucaaaagca gacuacgaaa aacacaaagu auacgcaugc      600

gaaguaacac accaaggauu aucaucccca guaacaaaau cauucaacag aggagaaugc      660

ugaggacuag uuauaagacu gacuagcccg augggccucc caacgggccc uccuccccuc      720

cuugcaccga gauuaauaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa      780

aaaaaaaaaa aaaaaaaaaa augcaucccc cccccccccc cccccccccc cccccccaaa      840

ggcucuuuuc agagccacca gaauu                                            865


<210>  911
<211>  865
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Ipilimumab LC without signale peptide

<400>  911
gggagaaagc uuaccgagau cgugcugacc cagagccccg gcacucucuc ccugagucca       60

ggggaaaggg ccaccuugag cugccgggca ucccaaagug ucgguagcuc cuaccuggcc      120

ugguaucagc agaagccggg ccaggcgccc cgccuccuga uuuacggggc cuucagcagg      180

gcaacgggca ucccagaccg guuuuccggu agugggagcg gcacugauuu caccuugacc      240

auuucccgcc uggagcccga agacuuugcc guguauuacu gucaacagua uggcagcagu      300

ccauggacuu ucgggcaggg uaccaaagua gagaucaaga ggacgguggc agcccccucc      360

gucuuuauuu ucccaccgag cgaugaacag cucaaauccg gcacugcgag uguggugugc      420

cugcugaaca auuuuuaccc ccgggaggcc aagguccaau ggaaagugga caacgcacuc      480

cagagcggca auucccagga gagcguaacc gaacaggaua guaaggacuc cacuuauagc      540

cugaguucca ccuugacccu gagcaaggcc gauuacgaga aacacaaggu guacgccugu      600

gaagucacgc aucaagggcu cagcucccca gugacuaaaa guuucaaccg cggugagugc      660

ugaggacuag uuauaagacu gacuagcccg augggccucc caacgggccc uccuccccuc      720

cuugcaccga gauuaauaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa      780

aaaaaaaaaa aaaaaaaaaa augcaucccc cccccccccc cccccccccc cccccccaaa      840

ggcucuuuuc agagccacca gaauu                                            865


<210>  912
<211>  865
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Ipilimumab LC without signale peptide

<400>  912
gggagaaagc uuaccgaaau cguccuaacc caaucccccg gcacacuauc ucucucccca       60

ggcgaacgcg caacacuauc cugccgcgcc ucacaaucag ucggcuccuc cuaccuagcc      120

ugguaccaac aaaaacccgg ccaagcaccc cgacuccuca ucuacggcgc cuucucccgc      180

gccacaggca ucccagaccg cuucuccggc uccggcuccg gcacagacuu cacacucacc      240

aucucacgcc ucgaacccga agacuucgcc gucuacuacu gccaacaaua cggaucaucc      300

cccuggaccu ucggacaagg caccaaaguc gaaaucaaac gcaccgucgc cgcccccucc      360

gucuucaucu ucccacccuc agacgaacaa cuaaaauccg gcaccgccuc aguagucugc      420

cuacuaaaca acuucuaccc ccgcgaagcc aaaguccaau ggaaagucga caacgcccuc      480

caauccggca acucacaaga aucagucacc gaacaagacu caaaagacuc caccuacucc      540

cuauccucca cccucacccu aucaaaagcc gacuacgaaa aacacaaagu auacgcgugc      600

gaaguaaccc accagggccu auccucaccc gucacaaaau ccuucaaccg cggcgaaugc      660

ugaggacuag uuauaagacu gacuagcccg augggccucc caacgggccc uccuccccuc      720

cuugcaccga gauuaauaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa      780

aaaaaaaaaa aaaaaaaaaa augcaucccc cccccccccc cccccccccc cccccccaaa      840

ggcucuuuuc agagccacca gaauu                                            865


<210>  913
<211>  865
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Ipilimumab LC without signale peptide

<400>  913
gggagaaagc uuaccgaaau cguacuaacc caaucacccg gcacccucuc ccucuccccc       60

ggcgaacgag ccacccuauc augccgcgcc ucccaauccg uaggcuccuc cuaccuagcc      120

ugguaccaac aaaaaccagg ccaagcaccc cgacuacuca ucuacggagc cuucucccgc      180

gccaccggca uccccgaccg cuucuccggc uccggcuccg gcaccgacuu cacccucacc      240

aucucccgcc ucgaacccga agacuucgcc gucuacuacu gccaacaaua cggaucaucc      300

cccuggaccu ucggccaagg caccaaaguc gaaaucaaac gcaccgucgc cgcccccucc      360

gucuucauau ucccacccuc cgacgaacaa cuaaaaucag gaaccgccuc cgucgucugc      420

cuacuaaaca acuucuaccc ccgcgaagcc aaaguacaau ggaaagucga caacgcccuc      480

caauccggca acucccaaga auccguaacc gaacaagacu ccaaagacuc aaccuauucc      540

cucuccucca cacucacacu auccaaagcc gacuacgaaa aacacaaagu cuacgccugc      600

gaaguaaccc accaaggccu cucaucaccc gucaccaaau ccuucaaccg cggcgaaugc      660

uaaggacuag uuauaagacu gacuagcccg augggccucc caacgggccc uccuccccuc      720

cuugcaccga gauuaauaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa      780

aaaaaaaaaa aaaaaaaaaa augcaucccc cccccccccc cccccccccc cccccccaaa      840

ggcucuuuuc agagccacca gaauu                                            865


<210>  914
<211>  865
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Ipilimumab LC without signale peptide

<400>  914
gggagaaagc uuaccgaaau cguccucacc caaucccccg gcacccuauc acucucaccc       60

ggcgaacgcg caacccucuc cugccgagcc ucccaauccg ucggcuccuc auaccucgcc      120

ugguaccaac aaaaacccgg ccaagcaccc cgucuccuca ucuacggcgc cuucucacgc      180

gccaccggca uccccgaccg cuucuccggc ucuggcucag gcaccgacuu cacccucacc      240

aucucccgcc ucgaacccga agacuucgcc gucuacuacu gccaacaaua cggaucaucc      300

cccuggaccu ucggccaagg cacaaaaguc gaaaucaaac gcaccgucgc cgccccaucc      360

gucuucaucu ucccacccuc cgacgaacaa cucaaauccg gcaccgccuc cgucgucugc      420

cuccucaaca acuucuaccc ccgcgaagcc aaaguccaau ggaaagucga caacgcccuc      480

caauccggca acucccaaga auccgucacc gaacaagacu ccaaagacuc caccuacuca      540

cucuccucca cccuuacccu cuccaaagcc gacuacgaaa aacacaaagu cuacgccugc      600

gaagucaccc accaaggccu cuccuccccc gucaccaaau ccuucaaccg cggcgaaugc      660

uaaggacuag uuauaagacu gacuagcccg augggccucc caacgggccc uccuccccuc      720

cuugcaccga gauuaauaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa      780

aaaaaaaaaa aaaaaaaaaa augcaucccc cccccccccc cccccccccc cccccccaaa      840

ggcucuuuuc agagccacca gaauu                                            865


<210>  915
<211>  865
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Ipilimumab LC without signale peptide

<400>  915
gggagaaagc uuaccgaaau aguacuaaca caaucaccag gaacacuauc acucucaccu       60

ggagaaagag caacauuauc cugcagagca ucacaaucug uaggaucuuc auaccuagca      120

ugguaccaac aaaaaccagg acaagcacca agauuacuaa uauauggagc auuuuccaga      180

gcaacaggca uaccagacag auucucagga ucaggaucag gaaccgacuu cacacuaaca      240

auaucaagac uagaaccaga agacuucgca guauacuacu gccaacaaua cggaucauca      300

ccauggacau ucggacaagg aacaaaagua gaaauaaaaa gaacagucgc agcaccauca      360

guauucauau ucccaccauc agacgaacaa uuaaaauccg gaacagcauc aguaguaugc      420

cuacuaaaua acuucuaccc aagagaagca aaaguacaau ggaaaguaga caacgcauua      480

caaucaggaa acucccaaga aucaguaaca gaacaagacu cuaaagacuc aacauacucc      540

cuaucaucaa cacuaacacu aucaaaagca gacuaugaaa aacacaaagu auacgcaugc      600

gaagucacac aucaaggacu aucaucacca guaacaaaau cauuuaacag aggagaaugc      660

uaaggacuag uuauaagacu gacuagcccg augggccucc caacgggccc uccuccccuc      720

cuugcaccga gauuaauaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa      780

aaaaaaaaaa aaaaaaaaaa augcaucccc cccccccccc cccccccccc cccccccaaa      840

ggcucuuuuc agagccacca gaauu                                            865


<210>  916
<211>  865
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Ipilimumab LC without signale peptide

<400>  916
gggagaaagc uuaccgaaau aguacuaaca caaucaccag gaacauuauc acuaucccca       60

ggagaaagag caacauuauc augcagagca ucacaaucag uaggaucauc auaccuagcc      120

ugguaccaac aaaaaccagg acaagcccca agauuacuaa uauacggagc auucucaaga      180

gcaacaggaa uaccagacag auucucaggu ucuggcucag gcacagacuu cacacucaca      240

auaucaagac uagaaccaga agacuucgcc guauacuacu gccaacaaua cggauccuca      300

ccauggacau ucggacaagg aacaaaagua gaaauaaaac gaacaguagc agcaccauca      360

guauucauau ucccaccauc agacgaacaa uuaaaaucag gaacagcauc aguaguaugc      420

cuauuaaaca acuucuaccc acgagaagcc aaaguccaau ggaaaguaga uaacgcauua      480

caaucaggua acucacaaga aucaguaaca gaacaagacu ccaaagacuc aacauacagc      540

cuaucaucaa cacuaacauu aucaaaagca gacuaugaaa aacacaaagu auacgcaugc      600

gagguaacac accaaggacu aucaucacca guaacaaaau cauucaauag aggagaaugc      660

uaaggacuag uuauaagacu gacuagcccg augggccucc caacgggccc uccuccccuc      720

cuugcaccga gauuaauaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa      780

aaaaaaaaaa aaaaaaaaaa augcaucccc cccccccccc cccccccccc cccccccaaa      840

ggcucuuuuc agagccacca gaauu                                            865


<210>  917
<211>  865
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Ipilimumab backbone Rituximab LC without signale peptide

<400>  917
gggagaaagc uuaccgagau cgugcugacc cagagccccg gcacccucuc ccugagcccg       60

ggggagcgcg ccacgcuguc cugccgggcc agccaguccg ucggcagcuc cuaccucgcg      120

ugguaccagc agaagcccgg gcaggcgccc cgccugcuga ucuacggcgc cuucagccgg      180

gccaccggga uccccgaccg cuucuccggc agcggcuccg ggaccgacuu cacccucacg      240

aucagccggc uggagccgga ggacuucgcc guguacuacu gccagcagua cggcuccagc      300

cccuggaccu ucgggcaggg caccaaggug gagaucaagc gcaccguggc ggcccccagc      360

guguucaucu ucccgcccag cgacgagcag cugaagagcg ggaccgccuc ggucgugugc      420

cuccugaaca acuucuaccc ccgggaggcc aaggugcagu ggaaggucga caacgcgcug      480

cagagcggca acagccagga gagcgugacg gagcaggaca gcaaggacag caccuacucg      540

cucagcagca cccugacccu gagcaaggcc gacuacgaga agcacaaggu guacgccugc      600

gaggucacgc accaggggcu cagcucgccc gugaccaaga gcuucaaccg cggggagugc      660

ugaggacuag uuauaagacu gacuagcccg augggccucc caacgggccc uccuccccuc      720

cuugcaccga gauuaauaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa      780

aaaaaaaaaa aaaaaaaaaa augcaucccc cccccccccc cccccccccc cccccccaaa      840

ggcucuuuuc agagccacca gaauu                                            865


<210>  918
<211>  865
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Ipilimumab backbone Rituximab LC without signale peptide

<400>  918
gggagaaagc uuaccgagau cgugcugacc cagagccccg gcacacucuc ccuuucuccu       60

ggggaaagag ccacucuguc augcagggcu agucaaagcg ucggauccuc uuacuuggca      120

ugguaucagc agaagccagg ucaggccccg cgguuacuga uuuacggcgc guucucgcgc      180

gcuacgggga uacccgaccg auuuucagga agcggcagug guaccgauuu cacacuaacu      240

aucucccguc ucgagccuga agacuuugcc guuuauuacu gucaacagua ugggucuagc      300

ccauggaccu ucggacaggg cacaaaagug gagauuaaga gaaccguggc ggcccccagc      360

guguucaucu ucccgcccag cgacgagcag cugaagagcg ggaccgccuc ggucgugugc      420

cuccugaaca acuucuaccc ccgggaggcc aaggugcagu ggaaggucga caacgcgcug      480

cagagcggca acagccagga gagcgugacg gagcaggaca gcaaggacag caccuacucg      540

cucagcagca cccugacccu gagcaaggcc gacuacgaga agcacaaggu guacgccugc      600

gaggucacgc accaggggcu cagcucgccc gugaccaaga gcuucaaccg cggugagugc      660

ugaggacuag uuauaagacu gacuagcccg augggccucc caacgggccc uccuccccuc      720

cuugcaccga gauuaauaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa      780

aaaaaaaaaa aaaaaaaaaa augcaucccc cccccccccc cccccccccc cccccccaaa      840

ggcucuuuuc agagccacca gaauu                                            865


<210>  919
<211>  865
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Ipilimumab backbone Rituximab LC without signale peptide

<400>  919
gggagaaagc uuaccgagau cgugcugacc cagagccccg gcacccugag ccugagcccc       60

ggcgagagag ccacccugag cugcagagcc agccagagcg ugggcagcag cuaccuggcc      120

ugguaccagc agaagcccgg ccaggccccc agacugcuga ucuacggcgc cuucagcaga      180

gccaccggca uccccgacag auucagcggc agcggcagcg gcaccgacuu cacccugacc      240

aucagcagac uggagcccga ggacuucgcc guguacuacu gccagcagua cggcagcagc      300

cccuggaccu ucggccaggg caccaaggug gagaucaaga gaaccguggc ggcccccagc      360

guguucaucu ucccgcccag cgacgagcag cugaagagcg ggaccgccuc ggucgugugc      420

cuccugaaca acuucuaccc ccgggaggcc aaggugcagu ggaaggucga caacgcgcug      480

cagagcggca acagccagga gagcgugacg gagcaggaca gcaaggacag caccuacucg      540

cucagcagca cccugacccu gagcaaggcc gacuacgaga agcacaaggu guacgccugc      600

gaggucacgc accaggggcu cagcucgccc gugaccaaga gcuucaaccg cggcgagugc      660

ugaggacuag uuauaagacu gacuagcccg augggccucc caacgggccc uccuccccuc      720

cuugcaccga gauuaauaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa      780

aaaaaaaaaa aaaaaaaaaa augcaucccc cccccccccc cccccccccc cccccccaaa      840

ggcucuuuuc agagccacca gaauu                                            865


<210>  920
<211>  3008
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Ipilimumab opt1 IRES construct

<400>  920
gggagaaagc uuaccaugga gcugggccuc agcuggaucu uccugcuggc cauccucaag       60

ggggugcagu gccaggugca gcuggucgag agcggcgggg gcguggugca gcccgggcgc      120

ucccuccggc ugagcugcgc cgccuccggc uucaccuuca gcuccuacac caugcacugg      180

guccgccagg cgccggggaa gggccuggag ugggugacgu ucaucagcua cgacggcaac      240

aacaaguacu acgccgacuc cgugaagggg cgguucacca ucagccgcga caacuccaag      300

aacacccucu accugcagau gaacagccug cgggccgagg acaccgccau cuacuacugc      360

gcccgcacgg gcuggcucgg gcccuucgac uacuggggcc aggggacccu ggucaccgug      420

uccagcgcgu ccaccaaggg ccccagcgug uucccccugg ccccguccag caaguccacg      480

agcggcggga ccgccgcccu cggcugccug gucaaggacu acuuccccga gcccgugacc      540

guguccugga acagcggggc gcugaccagc ggcguccaca cguuccccgc cgugcuccag      600

uccagcggcc uguacucccu gagcuccgug gucaccgugc cgagcuccag ccucgggacc      660

cagaccuaca ucugcaacgu gaaccacaag cccuccaaca cgaaggucga caagcgggug      720

gagcccaaga gcugcgacaa gacccacacg ugcccgcccu gccccgcccc cgagcugcug      780

ggcgggcccu ccguguuccu cuucccgccc aagcccaagg acacccugau gaucagccgc      840

acccccgagg ugaccugcgu cguggucgac gugucccacg aggacccgga ggucaaguuc      900

aacugguacg uggacggcgu ggagguccac aacgccaaga ccaagccccg ggaggagcag      960

uacaacagca ccuaccgcgu gguguccguc cugacggugc uccaccagga cuggcugaac     1020

gggaaggagu acaagugcaa ggugagcaac aaggcccugc ccgcgcccau cgagaagacc     1080

aucuccaagg ccaagggcca gccgcgggag ccccaggucu acacccuccc gcccagccgc     1140

gacgagcuga ccaagaacca ggugucccug acgugccucg ugaagggcuu cuaccccagc     1200

gacaucgccg ucgaguggga gagcaacggg cagcccgaga acaacuacaa gaccacgccc     1260

ccggugcugg acuccgacgg cagcuucuuc cuguacucca agcucaccgu ggacaagagc     1320

cgguggcagc aggggaacgu cuucuccugc agcgugaugc acgaggcccu gcacaaccac     1380

uacacccaga agucccugag ccucuccccc ggcaagugac caugcauuug aaagccgggg     1440

gugggagauc cggauugcca gucugcucga uaucgcaggc uggguccgug acuacccacu     1500

cccccuuuaa uuccgccccu cucccucccc ccccccuaac guuacuggcc gaagccgcuu     1560

ggaauaaggc cggugugcgu uugucuauau guuauuuucc accauauugc cgucuuuugg     1620

caaugugagg gcccggaaac cuggcccugu cuucuugacg agcauuccua ggggucuuuc     1680

cccucucgcc aaaggaaugc aaggucuguu gaaugucgug aaggaagcag uuccucugga     1740

agcuucuuga agacaaacaa cgucuguagc gacccuuugc aggcagcgga accccccacc     1800

uggcgacagg ugccucugcg gccaaaagcc acguguauaa gauacaccug caaaggcggc     1860

acaaccccag ugccacguug ugaguuggau aguuguggaa agagucaaau ggcucuccuc     1920

aagcguauuc aacaaggggc ugaaggaugc ccagaaggua ccccauugua ugggaucuga     1980

ucuggggccu cggugcacau gcuuuacgug uguuuagucg agguuaaaaa acgucuaggc     2040

cccccgaacc acggggacgu gguuuuccuu ugaaaaacac gaugauaaua gaucuaccau     2100

ggagaccccc gcccagcugc ucuuccugcu gcuccugugg cugccggaca ccacgggcga     2160

gaucgugcug acccagagcc ccggcacccu cucccugagc ccgggggagc gcgccacgcu     2220

guccugccgg gccagccagu ccgucggcag cuccuaccuc gcgugguacc agcagaagcc     2280

cgggcaggcg ccccgccugc ugaucuacgg cgccuucagc cgggccaccg ggauccccga     2340

ccgcuucucc ggcagcggcu ccgggaccga cuucacccuc acgaucagcc ggcuggagcc     2400

ggaggacuuc gccguguacu acugccagca guacggcucc agccccugga ccuucgggca     2460

gggcaccaag guggagauca agcgcaccgu cgccgccccc uccguguuca ucuucccgcc     2520

cagcgacgag cagcugaagu ccgggacggc cagcgugguc ugccuccuga acaacuucua     2580

cccccgggag gccaaggugc aguggaaggu ggacaacgcg cugcaguccg gcaacagcca     2640

ggagagcguc accgagcagg acuccaagga cagcaccuac ucccucagcu ccacccugac     2700

gcugagcaag gccgacuacg agaagcacaa gguguacgcc ugcgagguga cccaccaggg     2760

ccucuccagc cccgucacca aguccuucaa ccgcggggag ugcugaggac uaguuauaag     2820

acugacuagc ccgaugggcc ucccaacggg cccuccuccc cuccuugcac cgagauuaau     2880

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa     2940

aaaaugcauc cccccccccc cccccccccc cccccccccc aaaggcucuu uucagagcca     3000

ccagaauu                                                              3008


<210>  921
<211>  3008
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Ipilimumab opt3 IRES construct

<400>  921
gggagaaagc uuaccaugga gcugggccuc agcuggaucu uccuucuggc cauuuugaag       60

ggggugcagu gccaagucca guuaguugaa uccggaggug gcgugguaca gcccgggaga      120

ucucugaggc uaucaugugc ugcaagugga uuuaccuuca gcuccuacac aaugcacugg      180

gugcggcagg ccccuggcaa aggucucgag ugggucacuu uuauaucuua ugacgggaac      240

aauaaguacu augcggauuc ggugaaagga cgcuucacga ucucacgaga caacagcaag      300

aauacccugu accuucaaau gaacagucug cgugcugaag auacagccau uuauuacugc      360

gcaagaacug gcugguuggg cccauuugac uauugggggc agggaacccu cguuacagug      420

uccucugcca gcaccaaagg uccguccguc uucccccugg cuccuucaag uaagagcacu      480

ucuggcggga cagcagcccu gggaugucuc gugaaggauu acuuuccaga gcccguaacc      540

guuuccugga acucaggcgc uuuaacgagc ggugugcaua cuuucccugc cguccugcag      600

aguucugggc uuuacuccuu gagcucggug gugaccgucc caucuuccuc acugggaaca      660

cagacuuaua ucugcaaugu uaaucacaaa cccaguaaca ccaaggugga caaaagggua      720

gaaccuaaga gcugugauaa aacacauacc ugcccaccgu gucccgcgcc ugagcuacuc      780

ggcggcccau ccguguuucu guuucccccu aagccaaagg acacgcuuau gauuucucgg      840

acucccgagg ucacaugcgu gguuguggau gucagccacg aagacccgga ggugaaauuu      900

aauugguacg uagauggggu ugaagugcau aacgcaaaga ccaaaccucg cgaggagcaa      960

uauaauucaa cuuacagagu cgugaguguc cugacagugu ugcaccagga cuggcucaac     1020

ggaaaggaau auaaauguaa gguuuccaau aaagcccugc ccgcuccaau cgagaagacc     1080

auaagcaagg ccaaagguca gccuagggaa ccccaggugu acacguuacc acccucucgg     1140

gaugagcuga ccaagaacca aguaucacuc acaugccuug ucaaaggcuu cuauccuagu     1200

gacaucgcag uggaauggga gagcaauggg cagccagaga acaacuacaa gacuaccccg     1260

cccguucugg acuccgaugg aucuuucuuc uuguacucga aacuaacagu ggacaagagc     1320

cgcuggcagc aaggcaaugu cuucuccugu ucagugaugc acgaagcucu gcauaaccac     1380

uauacucaga agagucucuc ucugagcccu gguaaaugac caugcauuug aaagccgggg     1440

gugggagauc cggauugcca gucugcucga uaucgcaggc uggguccgug acuacccacu     1500

cccccuuuaa uuccgccccu cucccucccc ccccccuaac guuacuggcc gaagccgcuu     1560

ggaauaaggc cggugugcgu uugucuauau guuauuuucc accauauugc cgucuuuugg     1620

caaugugagg gcccggaaac cuggcccugu cuucuugacg agcauuccua ggggucuuuc     1680

cccucucgcc aaaggaaugc aaggucuguu gaaugucgug aaggaagcag uuccucugga     1740

agcuucuuga agacaaacaa cgucuguagc gacccuuugc aggcagcgga accccccacc     1800

uggcgacagg ugccucugcg gccaaaagcc acguguauaa gauacaccug caaaggcggc     1860

acaaccccag ugccacguug ugaguuggau aguuguggaa agagucaaau ggcucuccuc     1920

aagcguauuc aacaaggggc ugaaggaugc ccagaaggua ccccauugua ugggaucuga     1980

ucuggggccu cggugcacau gcuuuacgug uguuuagucg agguuaaaaa acgucuaggc     2040

cccccgaacc acggggacgu gguuuuccuu ugaaaaacac gaugauaaua gaucuaccau     2100

ggagaccccc gcccagcuuc ucuuccuucu guuguuaugg cugccugaca caacuggcga     2160

aaucgugcua acgcaaagcc cagggacccu cucccugucu ccgggagaga gagcuacacu     2220

uucaugcagg gcaagucaga gcgucgguuc cucuuaccug gccugguauc agcagaagcc     2280

cggccaagcg ccucgguugc ucauuuacgg ggcuuuuucg cgcgccacug gaauaccaga     2340

ucgauucuca ggcagcggua gugggaccga cuuuacacug accaucuccc gucuggaacc     2400

cgaggauuuc gcaguuuauu acugucagca guauggaucu agcccuugga cuuuuggcca     2460

gggcacaaaa guggaaauua agagaaccgu agccgcucca uccguguuca ucuuuccccc     2520

uucagacgag caacucaaaa gugggacggc aagcgucgug ugcuuacuga acaauuucua     2580

cccaagggag gccaagguuc aguggaaagu ggauaacgcu cugcagucug gaaauuccca     2640

ggaaucaguc acugagcaag acagcaagga uaguaccuau ucuuugucca gcacacugac     2700

ucuaucgaag gccgacuacg aaaaacacaa gguguacgcg ugugagguaa cccaucaggg     2760

ucucucuucc ccgguuacaa aaucauuuaa ccggggcgag ugcugaggac uaguuauaag     2820

acugacuagc ccgaugggcc ucccaacggg cccuccuccc cuccuugcac cgagauuaau     2880

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa     2940

aaaaugcauc cccccccccc cccccccccc cccccccccc aaaggcucuu uucagagcca     3000

ccagaauu                                                              3008


<210>  922
<211>  3008
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Ipilimumab opt4 IRES construct

<400>  922
gggagaaagc uuaccaugga gcugggccug agcuggaucu uccugcuggc cauccugaag       60

ggcgugcagu gccaggugca gcugguggag agcggcggcg gcguggugca gcccggcaga      120

agccugagac ugagcugcgc cgccagcggc uucaccuuca gcagcuacac caugcacugg      180

gugagacagg cccccggcaa gggccuggag ugggugaccu ucaucagcua cgacggcaac      240

aacaaguacu acgccgacag cgugaagggc agauucacca ucagcagaga caacagcaag      300

aacacccugu accugcagau gaacagccug agagccgagg acaccgccau cuacuacugc      360

gccagaaccg gcuggcuggg ccccuucgac uacuggggcc agggcacccu ggugaccgug      420

agcagcgcca gcaccaaggg ccccagcgug uucccccugg cccccagcag caagagcacc      480

agcggcggca ccgccgcccu gggcugccug gugaaggacu acuuccccga gcccgugacc      540

gugagcugga acagcggcgc ccugaccagc ggcgugcaca ccuuccccgc cgugcugcag      600

agcagcggcc uguacagccu gagcagcgug gugaccgugc ccagcagcag ccugggcacc      660

cagaccuaca ucugcaacgu gaaccacaag cccagcaaca ccaaggugga caagagagug      720

gagcccaaga gcugcgacaa gacccacacc ugcccccccu gccccgcccc cgagcugcug      780

ggcggcccca gcguguuccu guuccccccc aagcccaagg acacccugau gaucagcaga      840

acccccgagg ugaccugcgu ggugguggac gugagccacg aggaccccga ggugaaguuc      900

aacugguacg uggacggcgu ggaggugcac aacgccaaga ccaagcccag agaggagcag      960

uacaacagca ccuacagagu ggugagcgug cugaccgugc ugcaccagga cuggcugaac     1020

ggcaaggagu acaagugcaa ggugagcaac aaggcccugc ccgcccccau cgagaagacc     1080

aucagcaagg ccaagggcca gcccagagag ccccaggugu acacccugcc ccccagcaga     1140

gacgagcuga ccaagaacca ggugagccug accugccugg ugaagggcuu cuaccccagc     1200

gacaucgccg uggaguggga gagcaacggc cagcccgaga acaacuacaa gaccaccccc     1260

cccgugcugg acagcgacgg cagcuucuuc cuguacagca agcugaccgu ggacaagagc     1320

agauggcagc agggcaacgu guucagcugc agcgugaugc acgaggcccu gcacaaccac     1380

uacacccaga agagccugag ccugagcccc ggcaagugac caugcauuug aaagccgggg     1440

gugggagauc cggauugcca gucugcucga uaucgcaggc uggguccgug acuacccacu     1500

cccccuuuaa uuccgccccu cucccucccc ccccccuaac guuacuggcc gaagccgcuu     1560

ggaauaaggc cggugugcgu uugucuauau guuauuuucc accauauugc cgucuuuugg     1620

caaugugagg gcccggaaac cuggcccugu cuucuugacg agcauuccua ggggucuuuc     1680

cccucucgcc aaaggaaugc aaggucuguu gaaugucgug aaggaagcag uuccucugga     1740

agcuucuuga agacaaacaa cgucuguagc gacccuuugc aggcagcgga accccccacc     1800

uggcgacagg ugccucugcg gccaaaagcc acguguauaa gauacaccug caaaggcggc     1860

acaaccccag ugccacguug ugaguuggau aguuguggaa agagucaaau ggcucuccuc     1920

aagcguauuc aacaaggggc ugaaggaugc ccagaaggua ccccauugua ugggaucuga     1980

ucuggggccu cggugcacau gcuuuacgug uguuuagucg agguuaaaaa acgucuaggc     2040

cccccgaacc acggggacgu gguuuuccuu ugaaaaacac gaugauaaua gaucuaccau     2100

ggagaccccc gcccagcugc uguuccugcu gcugcugugg cugcccgaca ccaccggcga     2160

gaucgugcug acccagagcc ccggcacccu gagccugagc cccggcgaga gagccacccu     2220

gagcugcaga gccagccaga gcgugggcag cagcuaccug gccugguacc agcagaagcc     2280

cggccaggcc cccagacugc ugaucuacgg cgccuucagc agagccaccg gcauccccga     2340

cagauucagc ggcagcggca gcggcaccga cuucacccug accaucagca gacuggagcc     2400

cgaggacuuc gccguguacu acugccagca guacggcagc agccccugga ccuucggcca     2460

gggcaccaag guggagauca agagaaccgu ggccgccccc agcguguuca ucuucccccc     2520

cagcgacgag cagcugaaga gcggcaccgc cagcguggug ugccugcuga acaacuucua     2580

ccccagagag gccaaggugc aguggaaggu ggacaacgcc cugcagagcg gcaacagcca     2640

ggagagcgug accgagcagg acagcaagga cagcaccuac agccugagca gcacccugac     2700

ccugagcaag gccgacuacg agaagcacaa gguguacgcc ugcgagguga cccaccaggg     2760

ccugagcagc cccgugacca agagcuucaa cagaggcgag ugcugaggac uaguuauaag     2820

acugacuagc ccgaugggcc ucccaacggg cccuccuccc cuccuugcac cgagauuaau     2880

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa     2940

aaaaugcauc cccccccccc cccccccccc cccccccccc aaaggcucuu uucagagcca     3000

ccagaauu                                                              3008


<210>  923
<211>  2392
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Ipilimumab opt1 F2A construct

<400>  923
gggagaaagc uuaccaugga gcugggccuc agcuggaucu uccugcuggc cauccucaag       60

ggggugcagu gccaggugca gcuggucgag agcggcgggg gcguggugca gcccgggcgc      120

ucccuccggc ugagcugcgc cgccuccggc uucaccuuca gcuccuacac caugcacugg      180

guccgccagg cgccggggaa gggccuggag ugggugacgu ucaucagcua cgacggcaac      240

aacaaguacu acgccgacuc cgugaagggg cgguucacca ucagccgcga caacuccaag      300

aacacccucu accugcagau gaacagccug cgggccgagg acaccgccau cuacuacugc      360

gcccgcacgg gcuggcucgg gcccuucgac uacuggggcc aggggacccu ggucaccgug      420

uccagcgcgu ccaccaaggg ccccagcgug uucccccugg ccccguccag caaguccacg      480

agcggcggga ccgccgcccu cggcugccug gucaaggacu acuuccccga gcccgugacc      540

guguccugga acagcggggc gcugaccagc ggcguccaca cguuccccgc cgugcuccag      600

uccagcggcc uguacucccu gagcuccgug gucaccgugc cgagcuccag ccucgggacc      660

cagaccuaca ucugcaacgu gaaccacaag cccuccaaca cgaaggucga caagcgggug      720

gagcccaaga gcugcgacaa gacccacacg ugcccgcccu gccccgcccc cgagcugcug      780

ggcgggcccu ccguguuccu cuucccgccc aagcccaagg acacccugau gaucagccgc      840

acccccgagg ugaccugcgu cguggucgac gugucccacg aggacccgga ggucaaguuc      900

aacugguacg uggacggcgu ggagguccac aacgccaaga ccaagccccg ggaggagcag      960

uacaacagca ccuaccgcgu gguguccguc cugacggugc uccaccagga cuggcugaac     1020

gggaaggagu acaagugcaa ggugagcaac aaggcccugc ccgcgcccau cgagaagacc     1080

aucuccaagg ccaagggcca gccgcgggag ccccaggucu acacccuccc gcccagccgc     1140

gacgagcuga ccaagaacca ggugucccug acgugccucg ugaagggcuu cuaccccagc     1200

gacaucgccg ucgaguggga gagcaacggg cagcccgaga acaacuacaa gaccacgccc     1260

ccggugcugg acuccgacgg cagcuucuuc cuguacucca agcucaccgu ggacaagagc     1320

cgguggcagc aggggaacgu cuucuccugc agcgugaugc acgaggcccu gcacaaccac     1380

uacacccaga agucccugag ccucuccccc ggcaagguga agcagacacu caauuucgac     1440

cuucugaagu uggcuggaga uguugagucu aacccaggcc ccauggagac ccccgcccag     1500

cugcucuucc ugcugcuccu guggcugccg gacaccacgg gcgagaucgu gcugacccag     1560

agccccggca cccucucccu gagcccgggg gagcgcgcca cgcuguccug ccgggccagc     1620

caguccgucg gcagcuccua ccucgcgugg uaccagcaga agcccgggca ggcgccccgc     1680

cugcugaucu acggcgccuu cagccgggcc accgggaucc ccgaccgcuu cuccggcagc     1740

ggcuccggga ccgacuucac ccucacgauc agccggcugg agccggagga cuucgccgug     1800

uacuacugcc agcaguacgg cuccagcccc uggaccuucg ggcagggcac caagguggag     1860

aucaagcgca ccgucgccgc ccccuccgug uucaucuucc cgcccagcga cgagcagcug     1920

aaguccggga cggccagcgu ggucugccuc cugaacaacu ucuacccccg ggaggccaag     1980

gugcagugga agguggacaa cgcgcugcag uccggcaaca gccaggagag cgucaccgag     2040

caggacucca aggacagcac cuacucccuc agcuccaccc ugacgcugag caaggccgac     2100

uacgagaagc acaaggugua cgccugcgag gugacccacc agggccucuc cagccccguc     2160

accaaguccu ucaaccgcgg ggagugcuga ggacuaguua uaagacugac uagcccgaug     2220

ggccucccaa cgggcccucc uccccuccuu gcaccgagau uaauaaaaaa aaaaaaaaaa     2280

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaug cauccccccc     2340

cccccccccc cccccccccc ccccaaaggc ucuuuucaga gccaccagaa uu             2392


<210>  924
<211>  2392
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Ipilimumab opt3 F2A construct

<400>  924
gggagaaagc uuaccaugga gcugggccuc agcuggaucu uccuucuggc cauuuugaag       60

ggggugcagu gccaagucca guuaguugaa uccggaggug gcgugguaca gcccgggaga      120

ucucugaggc uaucaugugc ugcaagugga uuuaccuuca gcuccuacac aaugcacugg      180

gugcggcagg ccccuggcaa aggucucgag ugggucacuu uuauaucuua ugacgggaac      240

aauaaguacu augcggauuc ggugaaagga cgcuucacga ucucacgaga caacagcaag      300

aauacccugu accuucaaau gaacagucug cgugcugaag auacagccau uuauuacugc      360

gcaagaacug gcugguuggg cccauuugac uauugggggc agggaacccu cguuacagug      420

uccucugcca gcaccaaagg uccguccguc uucccccugg cuccuucaag uaagagcacu      480

ucuggcggga cagcagcccu gggaugucuc gugaaggauu acuuuccaga gcccguaacc      540

guuuccugga acucaggcgc uuuaacgagc ggugugcaua cuuucccugc cguccugcag      600

aguucugggc uuuacuccuu gagcucggug gugaccgucc caucuuccuc acugggaaca      660

cagacuuaua ucugcaaugu uaaucacaaa cccaguaaca ccaaggugga caaaagggua      720

gaaccuaaga gcugugauaa aacacauacc ugcccaccgu gucccgcgcc ugagcuacuc      780

ggcggcccau ccguguuucu guuucccccu aagccaaagg acacgcuuau gauuucucgg      840

acucccgagg ucacaugcgu gguuguggau gucagccacg aagacccgga ggugaaauuu      900

aauugguacg uagauggggu ugaagugcau aacgcaaaga ccaaaccucg cgaggagcaa      960

uauaauucaa cuuacagagu cgugaguguc cugacagugu ugcaccagga cuggcucaac     1020

ggaaaggaau auaaauguaa gguuuccaau aaagcccugc ccgcuccaau cgagaagacc     1080

auaagcaagg ccaaagguca gccuagggaa ccccaggugu acacguuacc acccucucgg     1140

gaugagcuga ccaagaacca aguaucacuc acaugccuug ucaaaggcuu cuauccuagu     1200

gacaucgcag uggaauggga gagcaauggg cagccagaga acaacuacaa gacuaccccg     1260

cccguucugg acuccgaugg aucuuucuuc uuguacucga aacuaacagu ggacaagagc     1320

cgcuggcagc aaggcaaugu cuucuccugu ucagugaugc acgaagcucu gcauaaccac     1380

uauacucaga agagucucuc ucugagcccu gguaaaguga agcagacacu caauuucgac     1440

cuucugaagu uggcuggaga uguugagucu aacccaggcc ccauggagac ccccgcccag     1500

cuucucuucc uucuguuguu auggcugccu gacacaacug gcgaaaucgu gcuaacgcaa     1560

agcccaggga cccucucccu gucuccggga gagagagcua cacuuucaug cagggcaagu     1620

cagagcgucg guuccucuua ccuggccugg uaucagcaga agcccggcca agcgccucgg     1680

uugcucauuu acggggcuuu uucgcgcgcc acuggaauac cagaucgauu cucaggcagc     1740

gguaguggga ccgacuuuac acugaccauc ucccgucugg aacccgagga uuucgcaguu     1800

uauuacuguc agcaguaugg aucuagcccu uggacuuuug gccagggcac aaaaguggaa     1860

auuaagagaa ccguagccgc uccauccgug uucaucuuuc ccccuucaga cgagcaacuc     1920

aaaaguggga cggcaagcgu cgugugcuua cugaacaauu ucuacccaag ggaggccaag     1980

guucagugga aaguggauaa cgcucugcag ucuggaaauu cccaggaauc agucacugag     2040

caagacagca aggauaguac cuauucuuug uccagcacac ugacucuauc gaaggccgac     2100

uacgaaaaac acaaggugua cgcgugugag guaacccauc agggucucuc uuccccgguu     2160

acaaaaucau uuaaccgggg cgagugcuga ggacuaguua uaagacugac uagcccgaug     2220

ggccucccaa cgggcccucc uccccuccuu gcaccgagau uaauaaaaaa aaaaaaaaaa     2280

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaug cauccccccc     2340

cccccccccc cccccccccc ccccaaaggc ucuuuucaga gccaccagaa uu             2392


<210>  925
<211>  2392
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Ipilimumab opt4 F2A construct

<400>  925
gggagaaagc uuaccaugga gcugggccug agcuggaucu uccugcuggc cauccugaag       60

ggcgugcagu gccaggugca gcugguggag agcggcggcg gcguggugca gcccggcaga      120

agccugagac ugagcugcgc cgccagcggc uucaccuuca gcagcuacac caugcacugg      180

gugagacagg cccccggcaa gggccuggag ugggugaccu ucaucagcua cgacggcaac      240

aacaaguacu acgccgacag cgugaagggc agauucacca ucagcagaga caacagcaag      300

aacacccugu accugcagau gaacagccug agagccgagg acaccgccau cuacuacugc      360

gccagaaccg gcuggcuggg ccccuucgac uacuggggcc agggcacccu ggugaccgug      420

agcagcgcca gcaccaaggg ccccagcgug uucccccugg cccccagcag caagagcacc      480

agcggcggca ccgccgcccu gggcugccug gugaaggacu acuuccccga gcccgugacc      540

gugagcugga acagcggcgc ccugaccagc ggcgugcaca ccuuccccgc cgugcugcag      600

agcagcggcc uguacagccu gagcagcgug gugaccgugc ccagcagcag ccugggcacc      660

cagaccuaca ucugcaacgu gaaccacaag cccagcaaca ccaaggugga caagagagug      720

gagcccaaga gcugcgacaa gacccacacc ugcccccccu gccccgcccc cgagcugcug      780

ggcggcccca gcguguuccu guuccccccc aagcccaagg acacccugau gaucagcaga      840

acccccgagg ugaccugcgu ggugguggac gugagccacg aggaccccga ggugaaguuc      900

aacugguacg uggacggcgu ggaggugcac aacgccaaga ccaagcccag agaggagcag      960

uacaacagca ccuacagagu ggugagcgug cugaccgugc ugcaccagga cuggcugaac     1020

ggcaaggagu acaagugcaa ggugagcaac aaggcccugc ccgcccccau cgagaagacc     1080

aucagcaagg ccaagggcca gcccagagag ccccaggugu acacccugcc ccccagcaga     1140

gacgagcuga ccaagaacca ggugagccug accugccugg ugaagggcuu cuaccccagc     1200

gacaucgccg uggaguggga gagcaacggc cagcccgaga acaacuacaa gaccaccccc     1260

cccgugcugg acagcgacgg cagcuucuuc cuguacagca agcugaccgu ggacaagagc     1320

agauggcagc agggcaacgu guucagcugc agcgugaugc acgaggcccu gcacaaccac     1380

uacacccaga agagccugag ccugagcccc ggcaagguga agcagacacu caauuucgac     1440

cuucugaagu uggcuggaga uguugagucu aacccaggcc ccauggagac ccccgcccag     1500

cugcuguucc ugcugcugcu guggcugccc gacaccaccg gcgagaucgu gcugacccag     1560

agccccggca cccugagccu gagccccggc gagagagcca cccugagcug cagagccagc     1620

cagagcgugg gcagcagcua ccuggccugg uaccagcaga agcccggcca ggcccccaga     1680

cugcugaucu acggcgccuu cagcagagcc accggcaucc ccgacagauu cagcggcagc     1740

ggcagcggca ccgacuucac ccugaccauc agcagacugg agcccgagga cuucgccgug     1800

uacuacugcc agcaguacgg cagcagcccc uggaccuucg gccagggcac caagguggag     1860

aucaagagaa ccguggccgc ccccagcgug uucaucuucc cccccagcga cgagcagcug     1920

aagagcggca ccgccagcgu ggugugccug cugaacaacu ucuaccccag agaggccaag     1980

gugcagugga agguggacaa cgcccugcag agcggcaaca gccaggagag cgugaccgag     2040

caggacagca aggacagcac cuacagccug agcagcaccc ugacccugag caaggccgac     2100

uacgagaagc acaaggugua cgccugcgag gugacccacc agggccugag cagccccgug     2160

accaagagcu ucaacagagg cgagugcuga ggacuaguua uaagacugac uagcccgaug     2220

ggccucccaa cgggcccucc uccccuccuu gcaccgagau uaauaaaaaa aaaaaaaaaa     2280

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaug cauccccccc     2340

cccccccccc cccccccccc ccccaaaggc ucuuuucaga gccaccagaa uu             2392


<210>  926
<211>  1621
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Ipilimumab HC with signale peptide

<400>  926
gggagaaagc uuaccaugga gcugggccuc agcuggaucu uccugcuggc cauccucaag       60

ggggugcagu gccaggugca gcuggucgag agcggcgggg gcguggugca gcccgggcgc      120

ucccuccggc ugagcugcgc cgccuccggc uucaccuuca gcuccuacac caugcacugg      180

guccgccagg cgccggggaa gggccuggag ugggugacgu ucaucagcua cgacggcaac      240

aacaaguacu acgccgacuc cgugaagggg cgguucacca ucagccgcga caacuccaag      300

aacacccucu accugcagau gaacagccug cgggccgagg acaccgccau cuacuacugc      360

gcccgcacgg gcuggcucgg gcccuucgac uacuggggcc aggggacccu ggucaccgug      420

uccagcgcgu ccaccaaggg ccccagcgug uucccccugg ccccguccag caaguccacg      480

agcggcggga ccgccgcccu cggcugccug gucaaggacu acuuccccga gcccgugacc      540

guguccugga acagcggggc gcugaccagc ggcguccaca cguuccccgc cgugcuccag      600

uccagcggcc uguacucccu gagcuccgug gucaccgugc cgagcuccag ccucgggacc      660

cagaccuaca ucugcaacgu gaaccacaag cccuccaaca cgaaggucga caagcgggug      720

gagcccaaga gcugcgacaa gacccacacg ugcccgcccu gccccgcccc cgagcugcug      780

ggcgggcccu ccguguuccu cuucccgccc aagcccaagg acacccugau gaucagccgc      840

acccccgagg ugaccugcgu cguggucgac gugucccacg aggacccgga ggucaaguuc      900

aacugguacg uggacggcgu ggagguccac aacgccaaga ccaagccccg ggaggagcag      960

uacaacagca ccuaccgcgu gguguccguc cugacggugc uccaccagga cuggcugaac     1020

gggaaggagu acaagugcaa ggugagcaac aaggcccugc ccgcgcccau cgagaagacc     1080

aucuccaagg ccaagggcca gccgcgggag ccccaggucu acacccuccc gcccagccgc     1140

gacgagcuga ccaagaacca ggugucccug acgugccucg ugaagggcuu cuaccccagc     1200

gacaucgccg ucgaguggga gagcaacggg cagcccgaga acaacuacaa gaccacgccc     1260

ccggugcugg acuccgacgg cagcuucuuc cuguacucca agcucaccgu ggacaagagc     1320

cgguggcagc aggggaacgu cuucuccugc agcgugaugc acgaggcccu gcacaaccac     1380

uacacccaga agucccugag ccucuccccc ggcaagugag gacuaguuau aagacugacu     1440

agcccgaugg gccucccaac gggcccuccu ccccuccuug caccgagauu aauaaaaaaa     1500

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaugc     1560

aucccccccc cccccccccc cccccccccc cccaaaggcu cuuuucagag ccaccagaau     1620

u                                                                     1621


<210>  927
<211>  1621
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Ipilimumab HC with signale peptide

<400>  927
gggagaaagc uuaccaugga gcucggccuc uccuggaucu uccuccucgc cauccucaag       60

ggcguccagu gccaggucca gcucgucgag uccggcggcg gcgucgucca gcccggccgc      120

ucccuccgcc ucuccugcgc cgccuccggc uucaccuucu ccuccuacac caugcacugg      180

guccgccagg cccccggcaa gggccucgag ugggucaccu ucaucuccua cgacggcaac      240

aacaaguacu acgccgacuc cgucaagggc cgcuucacca ucucccgcga caacuccaag      300

aacacccucu accuccagau gaacucccuc cgcgccgagg acaccgccau cuacuacugc      360

gcccgcaccg gcuggcucgg ccccuucgac uacuggggcc agggcacccu cgucaccguc      420

uccuccgccu ccaccaaggg ccccuccguc uucccccucg cccccuccuc caaguccacc      480

uccggcggca ccgccgcccu cggcugccuc gucaaggacu acuuccccga gcccgucacc      540

gucuccugga acuccggcgc ccucaccucc ggcguccaca ccuuccccgc cguccuccag      600

uccuccggcc ucuacucccu cuccuccguc gucaccgucc ccuccuccuc ccucggcacc      660

cagaccuaca ucugcaacgu caaccacaag cccuccaaca ccaaggucga caagcgcguc      720

gagcccaagu ccugcgacaa gacccacacc ugcccccccu gccccgcccc cgagcuccuc      780

ggcggccccu ccgucuuccu cuuccccccc aagcccaagg acacccucau gaucucccgc      840

acccccgagg ucaccugcgu cgucgucgac gucucccacg aggaccccga ggucaaguuc      900

aacugguacg ucgacggcgu cgagguccac aacgccaaga ccaagccccg cgaggagcag      960

uacaacucca ccuaccgcgu cgucuccguc cucaccgucc uccaccagga cuggcucaac     1020

ggcaaggagu acaagugcaa ggucuccaac aaggcccucc ccgcccccau cgagaagacc     1080

aucuccaagg ccaagggcca gccccgcgag ccccaggucu acacccuccc ccccucccgc     1140

gacgagcuca ccaagaacca ggucucccuc accugccucg ucaagggcuu cuaccccucc     1200

gacaucgccg ucgaguggga guccaacggc cagcccgaga acaacuacaa gaccaccccc     1260

cccguccucg acuccgacgg cuccuucuuc cucuacucca agcucaccgu cgacaagucc     1320

cgcuggcagc agggcaacgu cuucuccugc uccgucaugc acgaggcccu ccacaaccac     1380

uacacccaga agucccucuc ccucuccccc ggcaagugag gacuaguuau aagacugacu     1440

agcccgaugg gccucccaac gggcccuccu ccccuccuug caccgagauu aauaaaaaaa     1500

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaugc     1560

aucccccccc cccccccccc cccccccccc cccaaaggcu cuuuucagag ccaccagaau     1620

u                                                                     1621


<210>  928
<211>  1621
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Ipilimumab HC with signale peptide

<400>  928
gggagaaagc uuaccaugga gcugggccuc agcuggaucu uccuucuggc cauuuugaag       60

ggggugcagu gccaagucca guuaguugaa uccggaggug gcgugguaca gcccgggaga      120

ucucugaggc uaucaugugc ugcaagugga uuuaccuuca gcuccuacac aaugcacugg      180

gugcggcagg ccccuggcaa aggucucgag ugggucacuu uuauaucuua ugacgggaac      240

aauaaguacu augcggauuc ggugaaagga cgcuucacga ucucacgaga caacagcaag      300

aauacccugu accuucaaau gaacagucug cgugcugaag auacagccau uuauuacugc      360

gcaagaacug gcugguuggg cccauuugac uauugggggc agggaacccu cguuacagug      420

uccucugcca gcaccaaagg uccguccguc uucccccugg cuccuucaag uaagagcacu      480

ucuggcggga cagcagcccu gggaugucuc gugaaggauu acuuuccaga gcccguaacc      540

guuuccugga acucaggcgc uuuaacgagc ggugugcaua cuuucccugc cguccugcag      600

aguucugggc uuuacuccuu gagcucggug gugaccgucc caucuuccuc acugggaaca      660

cagacuuaua ucugcaaugu uaaucacaaa cccaguaaca ccaaggugga caaaagggua      720

gaaccuaaga gcugugauaa aacacauacc ugcccaccgu gucccgcgcc ugagcuacuc      780

ggcggcccau ccguguuucu guuucccccu aagccaaagg acacgcuuau gauuucucgg      840

acucccgagg ucacaugcgu gguuguggau gucagccacg aagacccgga ggugaaauuu      900

aauugguacg uagauggggu ugaagugcau aacgcaaaga ccaaaccucg cgaggagcaa      960

uauaauucaa cuuacagagu cgugaguguc cugacagugu ugcaccagga cuggcucaac     1020

ggaaaggaau auaaauguaa gguuuccaau aaagcccugc ccgcuccaau cgagaagacc     1080

auaagcaagg ccaaagguca gccuagggaa ccccaggugu acacguuacc acccucucgg     1140

gaugagcuga ccaagaacca aguaucacuc acaugccuug ucaaaggcuu cuauccuagu     1200

gacaucgcag uggaauggga gagcaauggg cagccagaga acaacuacaa gacuaccccg     1260

cccguucugg acuccgaugg aucuuucuuc uuguacucga aacuaacagu ggacaagagc     1320

cgcuggcagc aaggcaaugu cuucuccugu ucagugaugc acgaagcucu gcauaaccac     1380

uauacucaga agagucucuc ucugagcccu gguaaaugag gacuaguuau aagacugacu     1440

agcccgaugg gccucccaac gggcccuccu ccccuccuug caccgagauu aauaaaaaaa     1500

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaugc     1560

aucccccccc cccccccccc cccccccccc cccaaaggcu cuuuucagag ccaccagaau     1620

u                                                                     1621


<210>  929
<211>  1621
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Ipilimumab HC with signale peptide

<400>  929
gggagaaagc uuaccaugga gcugggccug agcuggaucu uccugcuggc cauccugaag       60

ggcgugcagu gccaggugca gcugguggag agcggcggcg gcguggugca gcccggcaga      120

agccugagac ugagcugcgc cgccagcggc uucaccuuca gcagcuacac caugcacugg      180

gugagacagg cccccggcaa gggccuggag ugggugaccu ucaucagcua cgacggcaac      240

aacaaguacu acgccgacag cgugaagggc agauucacca ucagcagaga caacagcaag      300

aacacccugu accugcagau gaacagccug agagccgagg acaccgccau cuacuacugc      360

gccagaaccg gcuggcuggg ccccuucgac uacuggggcc agggcacccu ggugaccgug      420

agcagcgcca gcaccaaggg ccccagcgug uucccccugg cccccagcag caagagcacc      480

agcggcggca ccgccgcccu gggcugccug gugaaggacu acuuccccga gcccgugacc      540

gugagcugga acagcggcgc ccugaccagc ggcgugcaca ccuuccccgc cgugcugcag      600

agcagcggcc uguacagccu gagcagcgug gugaccgugc ccagcagcag ccugggcacc      660

cagaccuaca ucugcaacgu gaaccacaag cccagcaaca ccaaggugga caagagagug      720

gagcccaaga gcugcgacaa gacccacacc ugcccccccu gccccgcccc cgagcugcug      780

ggcggcccca gcguguuccu guuccccccc aagcccaagg acacccugau gaucagcaga      840

acccccgagg ugaccugcgu ggugguggac gugagccacg aggaccccga ggugaaguuc      900

aacugguacg uggacggcgu ggaggugcac aacgccaaga ccaagcccag agaggagcag      960

uacaacagca ccuacagagu ggugagcgug cugaccgugc ugcaccagga cuggcugaac     1020

ggcaaggagu acaagugcaa ggugagcaac aaggcccugc ccgcccccau cgagaagacc     1080

aucagcaagg ccaagggcca gcccagagag ccccaggugu acacccugcc ccccagcaga     1140

gacgagcuga ccaagaacca ggugagccug accugccugg ugaagggcuu cuaccccagc     1200

gacaucgccg uggaguggga gagcaacggc cagcccgaga acaacuacaa gaccaccccc     1260

cccgugcugg acagcgacgg cagcuucuuc cuguacagca agcugaccgu ggacaagagc     1320

agauggcagc agggcaacgu guucagcugc agcgugaugc acgaggcccu gcacaaccac     1380

uacacccaga agagccugag ccugagcccc ggcaagugag gacuaguuau aagacugacu     1440

agcccgaugg gccucccaac gggcccuccu ccccuccuug caccgagauu aauaaaaaaa     1500

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaugc     1560

aucccccccc cccccccccc cccccccccc cccaaaggcu cuuuucagag ccaccagaau     1620

u                                                                     1621


<210>  930
<211>  1621
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Ipilimumab HC with signale peptide

<400>  930
gggagaaagc uuaccaugga gcugggccuc agcuggaucu uccugcuugc cauucugaag       60

ggggugcagu gccaagucca gcucguugaa uccggaggcg ggguggugca gcccggaaga      120

ucucugcggc uuagcugugc ugccuccggc uuuaccuucu cuagcuacac aaugcacugg      180

guccgccagg cgccugggaa aggacuggag ugggugacgu uuaucuccua ugacggcaac      240

aauaaguacu augcugauuc uguuaaaggc agauucacca uuagccggga caacuccaag      300

aauacacucu accugcaaau gaacagccug cgcgccgaag auaccgccau cuauuacugc      360

gcuagaacag gguggcucgg accguuugac uauuggggcc aggggacccu ggugacaguc      420

ucuuccgcca gcaccaaagg acccucugug uucccucuug cucccuccag caagucuacg      480

uccggcggga ccgccgcgcu gggaugucuc guuaaggauu acuuuccuga gcccgugaca      540

gucagcugga acuccggcgc ccugaccucu ggcgugcaua cauucccugc ugugcuucag      600

agcuccgggc uguacagccu cucuuccguc guuaccgugc cgagcucuag ccugggaacg      660

cagacauaua uuugcaaugu gaaucacaaa cccuccaaca ccaaggucga caaacgggug      720

gaaccuaagu cuugugauaa aacacauacc ugucccccuu gccccgcccc ggagcugcuc      780

ggcgggccua gcguuuuucu guuucccccu aagcccaagg acacccuuau gaucucccgc      840

acacccgagg ugacgugcgu cgugguugau gugagccacg aagacccuga ggucaaauuc      900

aauugguacg uggauggagu cgaagugcau aacgcuaaga ccaaaccgag agaggagcaa      960

uauaauucua cauaccgggu uguguccguc cugaccgugc uccaccagga cuggcugaac     1020

ggcaaggaau auaaauguaa gguuagcaau aaagcccuuc ccgcgccuau cgagaagaca     1080

auuucuaagg ccaaagggca gccccgcgaa ccucaggugu acacccugcc cccguccaga     1140

gaugagcuca cgaagaacca agucagccug acaugccugg ugaaaggauu cuauccuucc     1200

gacaucgcug uggaauggga gucuaauggc cagcccgaga acaacuacaa gaccaccccu     1260

cccguucucg acagcgaugg cuccuuuuuc cuguacucua aacuuacagu cgacaagagc     1320

cgguggcagc aagggaaugu guucuccugu agcgugaugc acgaagcccu gcauaaccac     1380

uauacccaga agucucucuc ccugagcccu ggaaaaugag gacuaguuau aagacugacu     1440

agcccgaugg gccucccaac gggcccuccu ccccuccuug caccgagauu aauaaaaaaa     1500

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaugc     1560

aucccccccc cccccccccc cccccccccc cccaaaggcu cuuuucagag ccaccagaau     1620

u                                                                     1621


<210>  931
<211>  1621
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Ipilimumab HC with signale peptide

<400>  931
gggagaaagc uuaccaugga auuagguuua uccuggaucu uucuccuagc aauacucaaa       60

ggaguacaau gccaaguaca auuaguggaa uccggaggag guguaguaca accaggaaga      120

ucacuaagac uaucaugcgc agcaucagga uuuacauucu caucauacac aaugcacugg      180

guaagacaag ccccaggaaa aggauuagaa uggguuacau uuauauccua cgacggaaac      240

aauaaauacu acgcagacuc agucaaagga agauucacua uaucaagaga caauucuaaa      300

aacacacuau accuacaaau gaacucucuc cgagcagaag auacagccau auacuacugc      360

gcaagaacag gaugguuagg accuuucgac uacuggggac aaggaacucu aguaacuguc      420

ucaucugccu caacaaaagg cccaucagua uuuccacuag ccccaucauc uaaaucuaca      480

ucagguggaa ccgcugcauu aggaugcuua guaaaagacu auuuucccga accaguaacu      540

guaucuugga acuccggagc acuuacuucu gguguacaca cauucccagc aguuuuacaa      600

agcucaggac uauacucucu aagcucagua guaacugucc caucaucauc ccuuggcacc      660

caaacauaca uauguaacgu aaaucacaaa cccaguaaua ccaaaguaga caaaagagua      720

gaacccaaau caugugauaa aacacacaca ugcccccccu gcccagcacc ugaacuucua      780

ggaggaccau cuguauuccu cuucccucca aaaccaaaag auacucucau gauaucacgc      840

acacccgaag uaacuugugu cguaguagac guaucacacg aagacccaga aguuaaauuc      900

aacugguaug uagacggagu agaaguccac aacgcaaaaa caaaaccacg agaagaacaa      960

uacaacucca ccuaucgcgu aguuucagua cuuacaguuc uccaccaaga uuggcuaaac     1020

ggaaaagaau acaaaugcaa aguaucaaau aaagcuuuac cugcaccaau agaaaaaaca     1080

auaaguaaag caaaagguca accacgagaa ccccaaguau auacacuucc accaucaaga     1140

gacgaacuua ccaaaaacca agucucacuc acaugcuuag uaaaaggauu uuacccauca     1200

gauauagcag uagaauggga auccaaugga caaccagaaa auaauuacaa aaccacacca     1260

ccuguacuag auucagacgg cucuuucuuu cuauacucua aacuaacagu ugauaaauca     1320

cgauggcaac aaggcaaugu auucucuugu ucugucaugc augaagcacu acacaaccac     1380

uacacacaaa aaucacuauc acuauccccc ggcaaaugag gacuaguuau aagacugacu     1440

agcccgaugg gccucccaac gggcccuccu ccccuccuug caccgagauu aauaaaaaaa     1500

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaugc     1560

aucccccccc cccccccccc cccccccccc cccaaaggcu cuuuucagag ccaccagaau     1620

u                                                                     1621


<210>  932
<211>  1621
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Ipilimumab HC with signale peptide

<400>  932
gggagaaagc uuaccaugga gcugggccuc agcuggaucu uccuguuggc cauucugaag       60

ggggugcagu gccaagucca gcucguggaa uccgguggcg ggguagugca gcccggcagg      120

agucugcggu ugagcugugc agccuccggu uuuaccuuca guagcuacac uaugcacugg      180

guccgccagg cgccagggaa aggccuggag ugggugaccu uuaucuccua ugacggcaac      240

aauaaguacu augccgauag cgugaaaggg agguucacga uuucccggga caacaguaag      300

aauacucucu accugcaaau gaacagccug cgcgcagaag auaccgccau cuauuacugc      360

gcaaggaccg guuggcucgg cccguuugac uauugggggc agggcacucu ggucaccgug      420

uccagcgcca guacgaaagg ucccuccgua uucccauugg cgcccagcuc caagaguacu      480

agcgggggca ccgccgcacu gggcugucuc gugaaggauu acuuuccaga gcccgucacu      540

guguccugga auagcggggc ccugaccagu ggugugcaua ccuucccagc cguccugcag      600

uccagcggcu uguacagucu cuccagcgug guaacggugc cgagcuccag ucuggggacu      660

cagaccuaua uuugcaacgu caaucacaaa cccagcaaca cuaaggugga caaacgggug      720

gaaccaaagu ccugugauaa aacccauacc ugucccccau gccccgcacc ggagcugcuc      780

ggcgguccca gcgucuuucu guucccaccc aagccaaaag acacuuugau gaucagucgc      840

acgcccgagg ugaccugcgu aguggucgau gugucccacg aagacccaga ggucaaguuu      900

aauugguacg uggauggcgu ggaaguacau aacgccaaga cuaaaccgag ggaggagcaa      960

uauaauagca ccuaccgggu ggucuccgug cugaccgucc uccaccagga cuggcugaac     1020

gggaaggaau auaaauguaa ggugaguaau aaagcgcugc ccgccccaau cgagaagacu     1080

auuagcaagg caaaaggcca gccccgcgaa ccacaggugu acacguugcc cccguccagg     1140

gaugagcuca ccaagaacca aguaagccug acuugccugg ugaaaggguu cuauccaagu     1200

gacaucgccg ucgaauggga guccaauggu cagcccgaga acaacuacaa gaccacuccc     1260

ccagugcucg acagcgaugg cuccuucuuu cuguacagua aauugaccgu cgacaagagc     1320

cgguggcagc aagggaaugu guucuccugc agcgugaugc acgaagcacu gcauaaccac     1380

uauacgcaga agagucucuc ccugagcccc ggcaaaugag gacuaguuau aagacugacu     1440

agcccgaugg gccucccaac gggcccuccu ccccuccuug caccgagauu aauaaaaaaa     1500

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaugc     1560

aucccccccc cccccccccc cccccccccc cccaaaggcu cuuuucagag ccaccagaau     1620

u                                                                     1621


<210>  933
<211>  1621
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Ipilimumab HC with signale peptide

<400>  933
gggagaaagc uuaccaugga acucggccua agcuggaucu uccuccuggc cauccucaaa       60

ggcguacagu gccaggucca acucguagaa uccggaggcg gcgucguaca acccggccgc      120

ucccuccgcc uauccugcgc agcuuccggc uucacauuca guucauacac caugcacugg      180

guccgacaag cccccggcaa aggacucgaa ugggucacuu uuaucucuua cgacggcaac      240

aauaaauacu acgcagacuc cgucaaaggc cgcuuuacaa ucucacguga caacuccaaa      300

aacacccuau accuccaaau gaacucccua cgcgcugaag acaccgccau uuacuauugc      360

gcccgcacag gcuggcuugg accauucgac uacuggggac aaggaacccu ugucaccguc      420

uccucugcca gcaccaaagg ccccuccguc uucccccucg cucccagcuc caaauccacg      480

ucaggcggca cugcagcccu cggaugccua gucaaagacu acuuccccga acccgucaca      540

gucucaugga acuccggagc ccucacuuca ggcguccaca ccuuccccgc aguacuacaa      600

ucuucaggcc uauacucccu aagcuccguc gucaccguac ccuccucauc ccucggaaca      660

caaaccuaca uaugcaacgu caaccacaaa cccucaaaca caaaaguaga caaacgcguc      720

gaacccaaau ccugcgacaa aacccauacc ugcccacccu gccccgcccc ggaacuccua      780

ggcggcccca gcgucuucuu auucccaccc aaacccaaag acacgcucau gauaaguaga      840

acccccgaag ugaccugcgu cgucgucgac gucucccacg aagacccuga aguuaaauuc      900

aacugguacg ucgacggcgu cgaaguucac aacgccaaaa ccaaaccccg agaagaacaa      960

uacaacucca ccuaccgagu cgucucagua cuaacagucc uccaccaaga cuggcucaac     1020

ggaaaagaau acaaaugcaa agucuccaac aaagcacuac cugccccaau cgagaaaaca     1080

aucuccaaag ccaaaggaca accccgugaa ccccagguau acacccuacc cccaucacgc     1140

gacgaacuca ccaaaaauca ggucagccua accugccucg ucaaaggauu cuaccccucc     1200

gacaucgccg ucgaauggga aagcaacggc caacccgaaa acaacuacaa aaccacccca     1260

cccguacucg acuccgacgg cuccuucuuc cucuacucca agcucaccgu cgacaaaucc     1320

cgcuggcaac agggaaacgu auucuccugc uccgucaugc acgaagcccu ccacaaccac     1380

uauacccaaa aaucacucuc ccuaucaccc ggaaaauaag gacuaguuau aagacugacu     1440

agcccgaugg gccucccaac gggcccuccu ccccuccuug caccgagauu aauaaaaaaa     1500

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaugc     1560

aucccccccc cccccccccc cccccccccc cccaaaggcu cuuuucagag ccaccagaau     1620

u                                                                     1621


<210>  934
<211>  1621
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Ipilimumab HC with signale peptide

<400>  934
gggagaaagc uuaccaugga acuaggccua ucauggaucu uccuccucgc cauccucaaa       60

ggcguccaau gccaggucca acucgucgaa uccggcggag gcgucgucca acccggccga      120

ucacuccgcc ucuccugcgc cgccuccggc uucacuuucu ccuccuacac aaugcacugg      180

guacgccaag ccccaggaaa aggacucgaa ugggucaccu ucaucuccua cgacggaaac      240

aacaaauacu acgccgacag cguuaaagga cgauucacaa ucucccgcga caacucuaaa      300

aacacccuau accuccaaau gaacucccuc cgcgccgaag acacagcaau cuacuacugc      360

gccagaaccg gauggcuagg ccccuucgac uacuggggcc aaggaacccu cgucacagua      420

uccuccgccu ccaccaaagg cccuuccgua uuuccccugg cccccucauc caaauccacc      480

agcggcggaa ccgccgcacu uggcugccuc guaaaagacu acuuccccga acccguaacc      540

gucuccugga acagcggcgc ccuaacguca ggcguacaca ccuuccccgc aguccuccaa      600

uccuccggac uauauagccu cuccagcgua guaacaguac ccuccagcuc ucucggcaca      660

caaaccuaua ucugcaacgu aaaccacaaa cccagcaaca ccaaaguuga caaacgcguu      720

gaacccaaau ccugcgacaa aacccacaca ugcccacccu gccccgcccc cgaacuccuc      780

ggcggucccu cagucuuccu cuucccacca aaaccuaaag acacucuaau gauaucccgc      840

accccagaag ugaccugcgu cguagucgac gucucccacg aagaccccga agucaaauuc      900

aacugguacg ucgacggcgu cgaaguacac aacgccaaaa ccaaaccccg agaagaacaa      960

uacaacucaa ccuacagagu cgucagcguc cucaccgucc uccaucagga cuggcucaac     1020

ggaaaagaau acaaaugcaa agucuccaac aaagcccuac cagcacccau agagaaaacc     1080

aucuccaaag ccaagggcca accacgcgaa ccccaaguau acacacuccc acccucacga     1140

gacgaacuca ccaagaacca aguaucuuua accugccuug ucaaaggcuu cuaccccucc     1200

gacaucgccg uggaauggga auccaacgga caacccgaaa acaacuacaa gaccacacca     1260

cccguccuug acucagacgg cuccuucuuc cucuauucca aacuuaccgu cgacaaaucc     1320

cgauggcaac aaggcaacgu cuucuccugc ucaguaaugc acgaagcccu acacaaccac     1380

uacacgcaaa aaucacucuc ccuguccccc ggaaaaugag gacuaguuau aagacugacu     1440

agcccgaugg gccucccaac gggcccuccu ccccuccuug caccgagauu aauaaaaaaa     1500

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaugc     1560

aucccccccc cccccccccc cccccccccc cccaaaggcu cuuuucagag ccaccagaau     1620

u                                                                     1621


<210>  935
<211>  1621
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Ipilimumab HC with signale peptide

<400>  935
gggagaaagc uuaccaugga acuuggccuu uccuggaucu uccuccucgc cauacucaaa       60

ggcguccaau gccaaguuca gcuagucgaa uccgguggcg gcguagucca acccggacgc      120

agccuccgac uauccugcgc cgccuccgga uucaccuucu ccucauacac caugcacugg      180

guccgccaag cccccggcaa aggccucgaa ugggucacau ucaucuccua cgauggaaac      240

aacaaauacu acgccgacuc agucaaaggc cgcuucacaa ucucccgaga caacuccaaa      300

aacacccuau accuccaaau gaacucacuu agagccgaag acacagcaau auacuacugc      360

gcccgcaccg gauggcuagg acccuucgac uacuggggcc aagggacccu cgucaccguu      420

agcuccgccu ccacaaaagg acccuccgua uucccccucg ccccauccuc caaauccaca      480

ucuggcggca ccgccgcacu cggaugccuc guaaaagacu acuuccccga acccgucaca      540

gucagcugga acucaggcgc ucucaccucc ggcguccaca cauucccggc aguccugcaa      600

agcagcggcc ucuacucccu aucaucugua gucaccgucc cauccucuuc ccucggcacc      660

caaaccuaca ucugcaacgu aaaccacaaa cccagcaaca ccaaagugga uaaacgagua      720

gaacccaaau cuugcgacaa aacccacacu ugcccacccu gccccgcccc agaacuucua      780

ggcggacccu ccgucuuccu cuucccaccc aaacccaaag acacccucau gaucucacgc      840

acccccgagg uaaccugcgu ugucgucgac gugucccacg aagacccuga agucaaguuc      900

aacugguacg ucgacggcgu cgaagugcac aacgccaaaa caaaaccacg cgaagaacaa      960

uauaacucaa ccuaccgcgu agucuccguc cuaaccgucc uccaccaaga cuggcuaaac     1020

ggcaaagaau acaaauguaa aguauccaau aaagcacucc ccgcccccau agagaaaacg     1080

aucuccaagg ccaaagguca accacgcgaa ccccaaguau acacccuacc accaucccgc     1140

gacgaacuca ccaaaaacca aguaucccua accugccuag ucaaaggcuu cuaccccucc     1200

gacaucgcag uagaauggga auccaacggc caaccagaaa acaacuacaa gacaacaccu     1260

cccguccucg acuccgacgg auccuucuuc uuauacucaa aacuaaccgu cgacaaaucu     1320

agauggcaac aaggcaacgu cuucucaugc uccguaaugc acgaagcucu ccacaaccac     1380

uacacccaaa aaucacucuc ccucuccccc ggcaaaugag gacuaguuau aagacugacu     1440

agcccgaugg gccucccaac gggcccuccu ccccuccuug caccgagauu aauaaaaaaa     1500

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaugc     1560

aucccccccc cccccccccc cccccccccc cccaaaggcu cuuuucagag ccaccagaau     1620

u                                                                     1621


<210>  936
<211>  1621
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Ipilimumab HC with signale peptide

<400>  936
gggagaaagc uuaccaugga acuaggacuc ucauggauau uuuuacuagc cauacucaaa       60

ggcguccaau gucaaguaca acuaguagaa ucaggcggag gaguugucca acccggccga      120

ucccuccgcu uaucaugugc agcaucugga uucacauuuu caucauacac aaugcacugg      180

gucagacaag ccccaggaaa agguuuagaa uggguaacau uuauaucaua cgacgguaac      240

aacaaauacu augcagacuc aguaaaagga agauuuacaa ucagcagaga caauagcaaa      300

aacacacuau accuacaaau gaacucccua cgagcagaag acacagccau cuauuacugu      360

gcacgaacag gauggcuagg accauucgau uacuggggcc aaggaacauu agucaccgua      420

ucuucugcau ccacaaaagg uccuucagua uuuccauuag cacccagcuc caaaucuaca      480

ucuggcggaa cagccgccuu aggaugcuua guuaaagauu acuuuccaga accaguaaca      540

guuucaugga acucaggagc ucuaacaucu ggaguacaca cauuuccagc aguccuacaa      600

ucauccggac uauauucacu aucaucagua guaacugucc ccucaucauc auuaggcaca      660

caaacuuaua uuugcaaugu aaaccauaaa ccaucaaaua caaaagucga caaaagagua      720

gaaccaaaau caugcgacaa aacccacaca uguccacccu gccccgcccc agaauuauua      780

ggaggaccau cugucuuccu uuucccacca aaaccaaaag acaccuuaau gauaucucga      840

acuccagaag uaacaugugu aguuguagau guuucacaug aagacccaga aguaaaauuc      900

aacugguacg ucgacggagu agaaguacac aaugcaaaaa caaaaccccg agaagaacaa      960

uacaacucca cauacagagu agucucagua cuaacaguac uccaucaaga cuggcuaaac     1020

ggaaaagaau acaaauguaa aguaaguaau aaagcacuac ccgcaccaau agaaaaaaca     1080

auaucaaaag caaaaggaca accaagagaa ccacaaguau auacacuacc uccauccaga     1140

gaugaauuaa caaaaaacca aguaagucua acauguuuag uaaaaggauu cuaucccagc     1200

gacauagcag ucgaauggga aucaaaugga caaccagaaa acaacuauaa aaccacacca     1260

ccaguauuag auucagacgg aucauuuuuc cuuuacucaa aauuaacagu agacaaaucc     1320

agauggcaac aaggcaaugu cuuuucaugc ucugucaugc acgaagcucu acauaaucac     1380

uacacucaaa aaucacuauc acucucacca ggcaaaugag gacuaguuau aagacugacu     1440

agcccgaugg gccucccaac gggcccuccu ccccuccuug caccgagauu aauaaaaaaa     1500

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaugc     1560

aucccccccc cccccccccc cccccccccc cccaaaggcu cuuuucagag ccaccagaau     1620

u                                                                     1621


<210>  937
<211>  1621
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Ipilimumab HC with signale peptide

<400>  937
gggagaaagc uuaccaugga acuaggacua uccuggauau uucuacuagc cauccuaaaa       60

ggaguacaau gucaaguaca auuaguagaa uccggaggcg gaguagucca acccggaaga      120

ucacuaagac ucaguugugc agcaucagga uucacauuuu caucauauac aaugcacugg      180

guuagacaag cacccggaaa aggacucgaa uggguaaccu uuaucuccua cgauggaaac      240

aauaaauauu acgcagauuc uguaaaaggc cgauucacaa uaucaagaga caacucuaaa      300

aauacauuau accuacaaau gaacucuuua agagcagaag acacagcaau auauuacugu      360

gcaagaacag gauggcucgg accauucgac uauuggggac aaggaaccuu aguaacagua      420

uccagcgcua gcacaaaagg cccuucuguc uucccauuag caccauccuc aaaaucaacu      480

ucuggcggaa cagcagcucu aggaugcuua guaaaagauu auuuuccaga accaguuacu      540

guauccugga acucaggagc acuaaccagu ggaguucaca cauuuccagc cguauuacaa      600

ucauccggau uauauucauu aucauccguc guaaccguac caagcucauc auuaggaaca      660

caaacauaca uaugcaacgu aaaucacaaa ccauccaaua caaaaguaga uaaaagagua      720

gaaccuaaau ccugugauaa aacacacaca ugcccaccau gcccagcacc agaauuacua      780

ggaggaccau caguauuccu auucccacca aaaccaaaag auacacuaau gauaucaaga      840

acaccagaag uaacuugugu agucguagac gucucacaug aagacccaga aguaaaauuu      900

aauugguaug uugacggagu cgaaguacac aacgccaaaa caaaaccacg agaagaacaa      960

uacaacucaa cauauagagu aguaucugua uuaacaguau uacaucaaga uugguuaaac     1020

ggaaaagaau acaaauguaa aguaucaaau aaagcucuac cagcaccaau agaaaagaca     1080

aucucaaaag caaaaggcca accucgagaa ccacaaguau acacacuacc accaucaaga     1140

gacgaauuaa ccaaaaacca agucucauua acaugcuuag uuaaagguuu cuaccccagc     1200

gacaucgcag uugaauggga aucaaacggu caaccugaaa acaacuauaa aacaacacca     1260

ccaguuuuag acucagaugg auccuuuuuc uuauacucaa aauuaacagu ugacaaauca     1320

agauggcaac aaggaaaugu cuuuucaugu uccgucaugc augaagcacu acacaaccau     1380

uacacccaaa aaucacucuc acuaucaccc gguaaauaag gacuaguuau aagacugacu     1440

agcccgaugg gccucccaac gggcccuccu ccccuccuug caccgagauu aauaaaaaaa     1500

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaugc     1560

aucccccccc cccccccccc cccccccccc cccaaaggcu cuuuucagag ccaccagaau     1620

u                                                                     1621


<210>  938
<211>  1621
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Ipilimumab backbone Rituximab HC with signale peptide

<400>  938
gggagaaagc uuaccaugga gcugggccuc agcuggaucu uccugcuggc cauccucaag       60

ggggugcagu gccaggugca gcuggucgag agcggcgggg gcguggugca gcccgggcgc      120

ucccuccggc ugagcugcgc cgccuccggc uucaccuuca gcuccuacac caugcacugg      180

guccgccagg cgccggggaa gggccuggag ugggugacgu ucaucagcua cgacggcaac      240

aacaaguacu acgccgacuc cgugaagggg cgguucacca ucagccgcga caacuccaag      300

aacacccucu accugcagau gaacagccug cgggccgagg acaccgccau cuacuacugc      360

gcccgcacgg gcuggcucgg gcccuucgac uacuggggcc aggggacccu ggucaccgug      420

uccagcgcgu ccaccaaggg ccccagcgug uucccccugg ccccguccag caaguccacg      480

agcggcggga ccgccgcccu cggcugccug gucaaggacu acuuccccga gcccgugacc      540

guguccugga acagcggggc gcugaccagc ggcguccaca cguuccccgc cgugcuccag      600

uccagcggcc uguacucccu gagcuccgug gucaccgugc cgagcuccag ccucgggacc      660

cagaccuaca ucugcaacgu gaaccacaag cccuccaaca cgaaggucga caagcgggug      720

gagcccaaga gcugcgacaa gacccacacg ugcccgcccu gccccgcccc cgagcugcug      780

ggcggcccga gcguguuccu cuucccgccc aagcccaagg acacccugau gaucagccgc      840

acccccgagg ucacgugcgu gguggucgac gugagccacg aggaccccga ggugaaguuc      900

aacugguacg ucgacggggu ggaggugcac aacgccaaga ccaagccccg ggaggagcag      960

uacaacagca ccuaccgcgu cgugagcgug cugaccgucc uccaccagga cuggcugaac     1020

ggcaaggagu acaagugcaa ggugucgaac aaggcccugc cggcccccau cgagaagacg     1080

aucagcaagg cgaagggcca gccgcgggag ccccaggucu acacccuccc gcccagccgc     1140

gacgagcuga ccaagaacca ggugucccug acgugccucg ugaagggcuu cuaccccagc     1200

gacaucgccg ucgaguggga gagcaacggg cagcccgaga acaacuacaa gaccacgccc     1260

ccggugcugg acuccgacgg cagcuucuuc cuguacucca agcucaccgu ggacaagagc     1320

cgguggcagc aggggaacgu cuucuccugc agcgugaugc acgaggcccu gcacaaccac     1380

uacacccaga agucccugag ccucuccccc ggcaagugag gacuaguuau aagacugacu     1440

agcccgaugg gccucccaac gggcccuccu ccccuccuug caccgagauu aauaaaaaaa     1500

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaugc     1560

aucccccccc cccccccccc cccccccccc cccaaaggcu cuuuucagag ccaccagaau     1620

u                                                                     1621


<210>  939
<211>  1621
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Ipilimumab backbone Rituximab HC with signale peptide

<400>  939
gggagaaagc uuaccaugga gcugggccuc agcuggaucu uccuucuggc cauuuugaag       60

ggggugcagu gccaagucca guuaguugaa uccggaggug gcgugguaca gcccgggaga      120

ucucugaggc uaucaugugc ugcaagugga uuuaccuuca gcuccuacac aaugcacugg      180

gugcggcagg ccccuggcaa aggucucgag ugggucacuu uuauaucuua ugacgggaac      240

aauaaguacu augcggauuc ggugaaagga cgcuucacga ucucacgaga caacagcaag      300

aauacccugu accuucaaau gaacagucug cgugcugaag auacagccau uuauuacugc      360

gcaagaacug gcugguuggg cccauuugac uauugggggc agggaacccu cguuacagug      420

uccucugcca gcaccaaagg uccguccguc uucccccugg cuccuucaag uaagagcacu      480

ucuggcggga cagcagcccu gggaugucuc gugaaggauu acuuuccaga gcccguaacc      540

guuuccugga acucaggcgc uuuaacgagc ggugugcaua cuuucccugc cguccugcag      600

aguucugggc uuuacuccuu gagcucggug gugaccgucc caucuuccuc acugggaaca      660

cagacuuaua ucugcaaugu uaaucacaaa cccaguaaca ccaaggugga caaaagggua      720

gaaccuaaga gcugugauaa aacacauacc ugcccaccgu gucccgcccc cgagcugcug      780

ggcggcccga gcguguuccu cuucccgccc aagcccaagg acacccugau gaucagccgc      840

acccccgagg ucacgugcgu gguggucgac gugagccacg aggaccccga ggugaaguuc      900

aacugguacg ucgacggggu ggaggugcac aacgccaaga ccaagccccg ggaggagcag      960

uacaacagca ccuaccgcgu cgugagcgug cugaccgucc uccaccagga cuggcugaac     1020

ggcaaggagu acaagugcaa ggugucgaac aaggcccugc cggcccccau cgagaagacg     1080

aucagcaagg cgaaggguca gccuagggaa ccccaggugu acacguuacc acccucucgg     1140

gaugagcuga ccaagaacca aguaucacuc acaugccuug ucaaaggcuu cuauccuagu     1200

gacaucgcag uggaauggga gagcaauggg cagccagaga acaacuacaa gacuaccccg     1260

cccguucugg acuccgaugg aucuuucuuc uuguacucga aacuaacagu ggacaagagc     1320

cgcuggcagc aaggcaaugu cuucuccugu ucagugaugc acgaagcucu gcauaaccac     1380

uauacucaga agagucucuc ucugagcccu gguaaaugag gacuaguuau aagacugacu     1440

agcccgaugg gccucccaac gggcccuccu ccccuccuug caccgagauu aauaaaaaaa     1500

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaugc     1560

aucccccccc cccccccccc cccccccccc cccaaaggcu cuuuucagag ccaccagaau     1620

u                                                                     1621


<210>  940
<211>  1621
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Ipilimumab backbone Rituximab HC with signale peptide

<400>  940
gggagaaagc uuaccaugga gcugggccug agcuggaucu uccugcuggc cauccugaag       60

ggcgugcagu gccaggugca gcugguggag agcggcggcg gcguggugca gcccggcaga      120

agccugagac ugagcugcgc cgccagcggc uucaccuuca gcagcuacac caugcacugg      180

gugagacagg cccccggcaa gggccuggag ugggugaccu ucaucagcua cgacggcaac      240

aacaaguacu acgccgacag cgugaagggc agauucacca ucagcagaga caacagcaag      300

aacacccugu accugcagau gaacagccug agagccgagg acaccgccau cuacuacugc      360

gccagaaccg gcuggcuggg ccccuucgac uacuggggcc agggcacccu ggugaccgug      420

agcagcgcca gcaccaaggg ccccagcgug uucccccugg cccccagcag caagagcacc      480

agcggcggca ccgccgcccu gggcugccug gugaaggacu acuuccccga gcccgugacc      540

gugagcugga acagcggcgc ccugaccagc ggcgugcaca ccuuccccgc cgugcugcag      600

agcagcggcc uguacagccu gagcagcgug gugaccgugc ccagcagcag ccugggcacc      660

cagaccuaca ucugcaacgu gaaccacaag cccagcaaca ccaaggugga caagagagug      720

gagcccaaga gcugcgacaa gacccacacc ugcccccccu gccccgcccc cgagcugcug      780

ggcggcccga gcguguuccu cuucccgccc aagcccaagg acacccugau gaucagccgc      840

acccccgagg ucacgugcgu gguggucgac gugagccacg aggaccccga ggugaaguuc      900

aacugguacg ucgacggggu ggaggugcac aacgccaaga ccaagccccg ggaggagcag      960

uacaacagca ccuaccgcgu cgugagcgug cugaccgucc uccaccagga cuggcugaac     1020

ggcaaggagu acaagugcaa ggugucgaac aaggcccugc cggcccccau cgagaagacg     1080

aucagcaagg cgaagggcca gcccagagag ccccaggugu acacccugcc ccccagcaga     1140

gacgagcuga ccaagaacca ggugagccug accugccugg ugaagggcuu cuaccccagc     1200

gacaucgccg uggaguggga gagcaacggc cagcccgaga acaacuacaa gaccaccccc     1260

cccgugcugg acagcgacgg cagcuucuuc cuguacagca agcugaccgu ggacaagagc     1320

agauggcagc agggcaacgu guucagcugc agcgugaugc acgaggcccu gcacaaccac     1380

uacacccaga agagccugag ccugagcccc ggcaagugag gacuaguuau aagacugacu     1440

agcccgaugg gccucccaac gggcccuccu ccccuccuug caccgagauu aauaaaaaaa     1500

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaugc     1560

aucccccccc cccccccccc cccccccccc cccaaaggcu cuuuucagag ccaccagaau     1620

u                                                                     1621


<210>  941
<211>  1564
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Ipilimumab HC without signale peptide

<400>  941
gggagaaagc uuacccaggu gcagcugguc gagagcggcg ggggcguggu gcagcccggg       60

cgcucccucc ggcugagcug cgccgccucc ggcuucaccu ucagcuccua caccaugcac      120

uggguccgcc aggcgccggg gaagggccug gaguggguga cguucaucag cuacgacggc      180

aacaacaagu acuacgccga cuccgugaag gggcgguuca ccaucagccg cgacaacucc      240

aagaacaccc ucuaccugca gaugaacagc cugcgggccg aggacaccgc caucuacuac      300

ugcgcccgca cgggcuggcu cgggcccuuc gacuacuggg gccaggggac ccuggucacc      360

guguccagcg cguccaccaa gggccccagc guguuccccc uggccccguc cagcaagucc      420

acgagcggcg ggaccgccgc ccucggcugc cuggucaagg acuacuuccc cgagcccgug      480

accguguccu ggaacagcgg ggcgcugacc agcggcgucc acacguuccc cgccgugcuc      540

caguccagcg gccuguacuc ccugagcucc guggucaccg ugccgagcuc cagccucggg      600

acccagaccu acaucugcaa cgugaaccac aagcccucca acacgaaggu cgacaagcgg      660

guggagccca agagcugcga caagacccac acgugcccgc ccugccccgc ccccgagcug      720

cugggcgggc ccuccguguu ccucuucccg cccaagccca aggacacccu gaugaucagc      780

cgcacccccg aggugaccug cgucgugguc gacguguccc acgaggaccc ggaggucaag      840

uucaacuggu acguggacgg cguggagguc cacaacgcca agaccaagcc ccgggaggag      900

caguacaaca gcaccuaccg cguggugucc guccugacgg ugcuccacca ggacuggcug      960

aacgggaagg aguacaagug caaggugagc aacaaggccc ugcccgcgcc caucgagaag     1020

accaucucca aggccaaggg ccagccgcgg gagccccagg ucuacacccu cccgcccagc     1080

cgcgacgagc ugaccaagaa ccaggugucc cugacgugcc ucgugaaggg cuucuacccc     1140

agcgacaucg ccgucgagug ggagagcaac gggcagcccg agaacaacua caagaccacg     1200

cccccggugc uggacuccga cggcagcuuc uuccuguacu ccaagcucac cguggacaag     1260

agccgguggc agcaggggaa cgucuucucc ugcagcguga ugcacgaggc ccugcacaac     1320

cacuacaccc agaagucccu gagccucucc cccggcaagu gaggacuagu uauaagacug     1380

acuagcccga ugggccuccc aacgggcccu ccuccccucc uugcaccgag auuaauaaaa     1440

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa     1500

ugcauccccc cccccccccc cccccccccc ccccccaaag gcucuuuuca gagccaccag     1560

aauu                                                                  1564


<210>  942
<211>  1564
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Ipilimumab HC without signale peptide

<400>  942
gggagaaagc uuacccaggu ccagcucguc gaguccggcg gcggcgucgu ccagcccggc       60

cgcucccucc gccucuccug cgccgccucc ggcuucaccu ucuccuccua caccaugcac      120

uggguccgcc aggcccccgg caagggccuc gaguggguca ccuucaucuc cuacgacggc      180

aacaacaagu acuacgccga cuccgucaag ggccgcuuca ccaucucccg cgacaacucc      240

aagaacaccc ucuaccucca gaugaacucc cuccgcgccg aggacaccgc caucuacuac      300

ugcgcccgca ccggcuggcu cggccccuuc gacuacuggg gccagggcac ccucgucacc      360

gucuccuccg ccuccaccaa gggccccucc gucuuccccc ucgcccccuc cuccaagucc      420

accuccggcg gcaccgccgc ccucggcugc cucgucaagg acuacuuccc cgagcccguc      480

accgucuccu ggaacuccgg cgcccucacc uccggcgucc acaccuuccc cgccguccuc      540

caguccuccg gccucuacuc ccucuccucc gucgucaccg uccccuccuc cucccucggc      600

acccagaccu acaucugcaa cgucaaccac aagcccucca acaccaaggu cgacaagcgc      660

gucgagccca aguccugcga caagacccac accugccccc ccugccccgc ccccgagcuc      720

cucggcggcc ccuccgucuu ccucuucccc cccaagccca aggacacccu caugaucucc      780

cgcacccccg aggucaccug cgucgucguc gacgucuccc acgaggaccc cgaggucaag      840

uucaacuggu acgucgacgg cgucgagguc cacaacgcca agaccaagcc ccgcgaggag      900

caguacaacu ccaccuaccg cgucgucucc guccucaccg uccuccacca ggacuggcuc      960

aacggcaagg aguacaagug caaggucucc aacaaggccc uccccgcccc caucgagaag     1020

accaucucca aggccaaggg ccagccccgc gagccccagg ucuacacccu cccccccucc     1080

cgcgacgagc ucaccaagaa ccaggucucc cucaccugcc ucgucaaggg cuucuacccc     1140

uccgacaucg ccgucgagug ggaguccaac ggccagcccg agaacaacua caagaccacc     1200

ccccccgucc ucgacuccga cggcuccuuc uuccucuacu ccaagcucac cgucgacaag     1260

ucccgcuggc agcagggcaa cgucuucucc ugcuccguca ugcacgaggc ccuccacaac     1320

cacuacaccc agaagucccu cucccucucc cccggcaagu gaggacuagu uauaagacug     1380

acuagcccga ugggccuccc aacgggcccu ccuccccucc uugcaccgag auuaauaaaa     1440

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa     1500

ugcauccccc cccccccccc cccccccccc ccccccaaag gcucuuuuca gagccaccag     1560

aauu                                                                  1564


<210>  943
<211>  1564
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Ipilimumab HC without signale peptide

<400>  943
gggagaaagc uuacccaggu gcaacugguc gagagcggcg ggggaguugu gcagcccggu       60

agaucccuca ggcuuucuug cgccgcuuca ggcuucaccu uuaguagcua cacaaugcac      120

uggguacggc aggcaccugg gaagggacug gaauggguga cuuucaucuc cuaugacggc      180

aacaauaaau acuaugccga uucugucaag ggucgcuuua cgauuucgcg agacaacagc      240

aaaaauaccu uguacuuaca gaugaacuca cugcgugcgg aggauacagc uauauauuac      300

ugugccagaa cuggguggcu aggaccauuc gacuauuggg gccaaggcac ccucgugaca      360

guuaguuccg caucuaccaa ggggccgagc guguuucccc uggccccuuc cucaaaaagu      420

acuagcggag guacagcugc acuuggcugc cuggucaagg auuacuuccc agaacccgug      480

accguaucuu ggaacuccgg ggccuugacg ucaggaguuc auacuuuucc ugcugugcuc      540

cagagcagug gccuguacuc ucuguccagc gucgugaccg ugccaucguc uucccucggu      600

acacagacuu auaucuguaa ugucaaucac aagcccucaa acaccaaagu ugacaagagg      660

guggagccua aaaguugcga uaagacacau accuguccac cgugccccgc cccugaauua      720

cuugggggac caagcguauu ccuguuuccc ccuaaaccaa aggacacguu gaugauuucc      780

cggacucccg aggugacaug ugucgugguu gaugugucuc acgaggaccc ggaagucaag      840

uucaauuggu acguggaugg cguagagguu cauaacgcga aaaccaagcc ucgcgaagaa      900

caguauaaua gcacuuacag aguggucuca gugcugacag uccuacacca agacuggcuc      960

aacggcaaag aguauaagug caaagugagu aauaaggcac ugcccgcccc aaucgagaaa     1020

accauuucca aggcuaaggg gcagccuagg gagccccagg uuuacacgcu uccacccagc     1080

cgggaugaac ugaccaaaaa ccaggugucu uugacauguc ucguaaaggg auuuuauccu     1140

ucagacaucg ccgucgagug ggaaaguaau ggucaaccag agaacaacua caaaacuacc     1200

ccgcccgugc uggacagcga uggcuccuuc uuuuuauacu cuaagcugac aguugacaaa     1260

ucgcgcuggc agcaggggaa uguguucagc ugcuccguca ugcacgaggc acuccauaac     1320

cacuauacuc aaaagucacu uagucugucu ccuggaaagu gaggacuagu uauaagacug     1380

acuagcccga ugggccuccc aacgggcccu ccuccccucc uugcaccgag auuaauaaaa     1440

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa     1500

ugcauccccc cccccccccc cccccccccc ccccccaaag gcucuuuuca gagccaccag     1560

aauu                                                                  1564


<210>  944
<211>  1564
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Ipilimumab HC without signale peptide

<400>  944
gggagaaagc uuacccaggu gcagcuggug gagagcggcg gcggcguggu gcagcccggc       60

agaagccuga gacugagcug cgccgccagc ggcuucaccu ucagcagcua caccaugcac      120

ugggugagac aggcccccgg caagggccug gaguggguga ccuucaucag cuacgacggc      180

aacaacaagu acuacgccga cagcgugaag ggcagauuca ccaucagcag agacaacagc      240

aagaacaccc uguaccugca gaugaacagc cugagagccg aggacaccgc caucuacuac      300

ugcgccagaa ccggcuggcu gggccccuuc gacuacuggg gccagggcac ccuggugacc      360

gugagcagcg ccagcaccaa gggccccagc guguuccccc uggcccccag cagcaagagc      420

accagcggcg gcaccgccgc ccugggcugc cuggugaagg acuacuuccc cgagcccgug      480

accgugagcu ggaacagcgg cgcccugacc agcggcgugc acaccuuccc cgccgugcug      540

cagagcagcg gccuguacag ccugagcagc guggugaccg ugcccagcag cagccugggc      600

acccagaccu acaucugcaa cgugaaccac aagcccagca acaccaaggu ggacaagaga      660

guggagccca agagcugcga caagacccac accugccccc ccugccccgc ccccgagcug      720

cugggcggcc ccagcguguu ccuguucccc cccaagccca aggacacccu gaugaucagc      780

agaacccccg aggugaccug cgugguggug gacgugagcc acgaggaccc cgaggugaag      840

uucaacuggu acguggacgg cguggaggug cacaacgcca agaccaagcc cagagaggag      900

caguacaaca gcaccuacag aguggugagc gugcugaccg ugcugcacca ggacuggcug      960

aacggcaagg aguacaagug caaggugagc aacaaggccc ugcccgcccc caucgagaag     1020

accaucagca aggccaaggg ccagcccaga gagccccagg uguacacccu gccccccagc     1080

agagacgagc ugaccaagaa ccaggugagc cugaccugcc uggugaaggg cuucuacccc     1140

agcgacaucg ccguggagug ggagagcaac ggccagcccg agaacaacua caagaccacc     1200

ccccccgugc uggacagcga cggcagcuuc uuccuguaca gcaagcugac cguggacaag     1260

agcagauggc agcagggcaa cguguucagc ugcagcguga ugcacgaggc ccugcacaac     1320

cacuacaccc agaagagccu gagccugagc cccggcaagu gaggacuagu uauaagacug     1380

acuagcccga ugggccuccc aacgggcccu ccuccccucc uugcaccgag auuaauaaaa     1440

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa     1500

ugcauccccc cccccccccc cccccccccc ccccccaaag gcucuuuuca gagccaccag     1560

aauu                                                                  1564


<210>  945
<211>  1564
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Ipilimumab HC without signale peptide

<400>  945
gggagaaagc uuacccaggu gcaacugguc gagagcggcg ggggaguugu gcagcccggc       60

agaucccucc ggcugucuug cgccgcuagc ggguucaccu uuuccucuua cacaaugcac      120

ugggugcgcc aggccccugg aaagggccuu gaauggguca cguucaucag cuaugacggg      180

aacaauaaau acuaugcgga uuccgugaag ggaagauuua ccauuucucg ggacaacagc      240

aaaaauacac uguaccucca gaugaacucc cugcgcgcug aggauaccgc caucuauuac      300

ugugccagaa caggcuggcu uggcccguuc gacuauuggg ggcaaggaac ccugguuaca      360

gugagcucug cuuccaccaa gggccccagc gucuuuccuc ucgcccccuc uuccaaaagc      420

acgucugggg gaaccgcugc ccugggcugc cuggugaagg auuacuuccc ugaacccguu      480

acaguguccu ggaauagcgg ggcgcucacc uccggagucc auacauuucc ugccgugcug      540

cagucuagcg gccuuuacuc ccugagcucu guggucaccg uuccguccag cucucucggc      600

acgcagacau auauuuguaa cgugaaucac aagcccagca acaccaaagu ggacaagcgg      660

gucgagccua aauccugcga uaagacacau accugucccc cuugccccgc uccggaacug      720

cuugggggac cuucuguguu ccuguuuccc ccuaaaccca aggacacccu caugaucagc      780

cgcacacccg agguuacgug uguggucgug gauguuuccc acgaggaccc ugaagugaag      840

uucaauuggu acgucgaugg cguggagguc cauaacgcca aaaccaagcc gagagaagaa      900

caguauaaua gcacauaccg ggugguuucu gugcugaccg uccugcacca agacuggcuc      960

aacgggaaag aguauaagug caaagugucc aauaaggcuc ugcccgcccc uauugagaaa     1020

acaaucagca aggcgaaggg acagccccgc gagccucagg uuuacacccu ucccccgucu     1080

agagaugaac ugacgaaaaa ccaggugucc cucacauguc uggucaaggg cuuuuauccu     1140

agcgacaucg ccguggagug ggaauccaau gggcaacccg agaacaacua caaaaccacc     1200

ccucccgugc uugacucuga uggcagcuuc uuucuguacu ccaagcucac aguugacaaa     1260

ucucgguggc agcagggaaa ugucuucagc ugcuccguga ugcacgaggc ucugcauaac     1320

cacuauaccc aaaagagccu gucucucucc ccuggcaagu gaggacuagu uauaagacug     1380

acuagcccga ugggccuccc aacgggcccu ccuccccucc uugcaccgag auuaauaaaa     1440

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa     1500

ugcauccccc cccccccccc cccccccccc ccccccaaag gcucuuuuca gagccaccag     1560

aauu                                                                  1564


<210>  946
<211>  1564
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Ipilimumab HC without signale peptide

<400>  946
gggagaaagc uuacccaagu ucaacuagua gaaucaggag gaggagucgu ccaaccaggc       60

agaucacuaa gacuaucaug ugcagccucu ggcuucacau ucucuucuua uacaaugcac      120

uggguaagac aagcaccagg aaaaggacua gaauggguaa cauucauauc uuacgacgga      180

aauaacaaau auuacgcuga uucuguaaaa gguagauuca caauuucuag agacaauagu      240

aaaaauacau uauaccucca aaugaauagu cuuagagcag aagauacagc aauauacuau      300

ugugcacgaa caggaugguu aggaccauuc gauuacuggg gucaaggaac auuaguaaca      360

guaucaucug caucaacaaa agguccuuca guauucccac ucgcaccauc aucaaaaucc      420

acaucaggag gaacugcagc ccucggaugc cuagucaaag acuacuuccc agaaccagua      480

accguaucuu ggaacuccgg agcauuaaca ucuggaguac auacauuccc ugcaguacuc      540

caaucaucag gacuauacuc acuauccucc guaguaaccg ucccuucauc aucucuaggu      600

acacaaacuu acauaugcaa cguaaaucac aaaccaucua auacaaaagu agacaaaaga      660

gucgaaccaa aaucaugcga caaaacccac acaugccccc caugcccagc acccgaacua      720

cucggaggac caucaguauu ucuauuucca ccaaaaccaa aagauacacu aaugauauca      780

cgaacaccug aaguaaccug uguugucguc gacguaucgc acgaagaccc agaaguaaaa      840

uuuaauuggu acguagacgg uguagaaguu cacaaugcaa aaacaaaacc aagagaagaa      900

caauacaacu caacauauag aguaguuucu gucuuaaccg ucuuacacca agauugguua      960

aacgguaaag aauauaaaug caaaguaucu aauaaagcuc uacccgcccc aaucgaaaaa     1020

acaauaucaa aagccaaagg ccaaccucga gaaccacaag uauacacacu acccccuuca     1080

agagaugaac uaacaaaaaa ccaaguaagc cuaacaugcc uaguaaaagg cuuuuaucca     1140

ucagacauag caguagaaug ggaaucuaac ggucaaccug aaaauaacua uaaaacaaca     1200

ccaccaguac uagacucaga uggaucauuc uuucuauacu caaaauuaac aguagauaaa     1260

ucaagauggc aacaaggaaa cguuuuuucu uguucuguaa ugcacgaagc acuacacaau     1320

cacuauaccc aaaaaucucu cagccuauca cccggaaaau gaggacuagu uauaagacug     1380

acuagcccga ugggccuccc aacgggcccu ccuccccucc uugcaccgag auuaauaaaa     1440

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa     1500

ugcauccccc cccccccccc cccccccccc ccccccaaag gcucuuuuca gagccaccag     1560

aauu                                                                  1564


<210>  947
<211>  1564
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Ipilimumab HC without signale peptide

<400>  947
gggagaaagc uuacccaggu gcaacugguc gagagcggcg gggguguggu acagcccggc       60

aggucccucc ggcugaguug cgccgcaagc ggguucaccu uuuccaguua cacuaugcac      120

ugggugcgcc aggccccagg caaggguuug gaauggguca ccuucaucag cuaugacggg      180

aacaauaaau acuaugcgga uuccgugaag ggcagguuua cgauuagccg ggacaacucc      240

aaaaauacuc uguaccucca gaugaacagu cugcgcgccg aggauaccgc aaucuauuac      300

ugugccagga ccggcugguu ggggccguuc gacuauuggg gucaaggcac ucuggugacc      360

gucagcuccg caagcacgaa ggggcccagu guguuuccac ucgcccccuc cagcaaaucc      420

accaguggcg guaccgcggc ccuggggugc cugguaaagg auuacuuccc agaacccgug      480

acugucagcu ggaacuccgg cgcacucacc agcggcgugc auaccuuucc agccgugcug      540

cagaguuccg gguuguacag ccugaguucc gucgugacgg uaccgagcag cucccucggu      600

acucagaccu auauuuguaa ugugaaucac aagcccagua acacuaaagu cgacaagcgg      660

guggagccaa aaagcugcga uaagacccau accugucccc caugccccgc cccggaacug      720

cugggcgggc ccuccguguu cuuguuucca cccaaaccaa aggacacucu caugaucagc      780

cgcacgcccg aggucaccug ugugguagug gaugucaguc acgaggaccc agaagugaaa      840

uucaauuggu acgucgaugg cguggaggug cauaacgcaa agacuaagcc gagggaagaa      900

caguauaauu ccaccuaccg gguagugagc guccugaccg ugcugcacca agacuggcuc      960

aacgguaaag aguauaagug caaagucucc aauaaggccc ugcccgcgcc aauugagaaa     1020

acuaucagua aggccaaggg ccagccccgc gagccacagg uguacacguu gcccccgagc     1080

agggaugaac ugaccaaaaa ccaggugucc cucacuuguc ugguaaaggg guuuuaucca     1140

agcgacaucg caguggagug ggaaaguaau ggccaacccg agaacaacua caaaaccacu     1200

cccccagucc uggacuccga ugggagcuuc uucuuguacu ccaagcucac uguggacaaa     1260

agucgguggc agcaggguaa ugucuuuagc ugcuccguga ugcacgaggc ccugcauaac     1320

cacuauacgc aaaagagccu gagucucucc cccggcaagu gaggacuagu uauaagacug     1380

acuagcccga ugggccuccc aacgggcccu ccuccccucc uugcaccgag auuaauaaaa     1440

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa     1500

ugcauccccc cccccccccc cccccccccc ccccccaaag gcucuuuuca gagccaccag     1560

aauu                                                                  1564


<210>  948
<211>  1564
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Ipilimumab HC without signale peptide

<400>  948
gggagaaagc uuacccaagu ccagcuagua gaauccggcg gaggcgucgu ccaaccagga       60

cgcucgcuaa gacucagcug cgccgcaucu ggcuucacau ucagcucaua cacaaugcac      120

ugggucagac aagcuccagg caaaggccuc gaauggguca cauucauauc auacgacggc      180

aacaacaaau acuacgccga cuccguaaaa ggccgcuuca ccaucuccag agacaacucc      240

aaaaacaccc uauaccucca aaugaacuca cucagagccg aagacaccgc aaucuacuac      300

ugcgcaagaa ccggcuggcu uggccccuuc gauuacuggg gacaaggcac ccucgucacc      360

gucucauccg cauccaccaa aggcccaucc gucuuccccc ucgcaccauc auccaaaucc      420

accagcggag guaccgccgc acucggcugc cuagucaaag acuacuuccc cgaaccuguc      480

acagucuccu ggaacuccgg agcccugaca ucgggcgucc acacauuccc cgccguccua      540

caaagcuccg gccucuacag ccucuccuca gucgucaccg uacccuccuc cagccucgga      600

acacaaaccu acaucugcaa cguuaaccac aaaccuucca acaccaaagu cgacaaacga      660

gucgaaccca aaucgugcga caaaacccau accugcccac ccugccccgc ccccgaacuc      720

cucggcggcc cauccgucuu ccuauuccca cccaaaccaa aggacacacu caugauauca      780

cgaaccccug aagucacgug cgucgucguc gacguuucac acgaagaccc cgaagucaaa      840

uucaacuggu acguagacgg agucgaaguc cacaacgcca aaaccaaacc ccgagaagaa      900

caauacaacu cuaccuaccg cgucguaucc guccucaccg uccuccacca agacuggcua      960

aacggcaaag aauacaagug caaaguuucg aacaaagccc uccccgcacc caucgagaaa     1020

accaucucca aagccaaagg acaaccccgc gaaccccaag uguacacccu cccacccucg     1080

cgugacgaac ucaccaaaaa ucaagucucu cuaaccugcc ucguaaaagg cuucuacccc     1140

uccgacauag caguagaaug ggaaucuaac ggccagcccg aaaacaacua caaaacaacc     1200

ccacccguac ucgacuccga cggcucauuc uuccucuacu caaaacucac cgucgauaaa     1260

ucccgcuggc aacaaggcaa ugucuucuca ugcagcguca ugcacgaagc acuccacaac     1320

cacuacacac aaaagagccu cucccuaucc cccggcaaau gaggacuagu uauaagacug     1380

acuagcccga ugggccuccc aacgggcccu ccuccccucc uugcaccgag auuaauaaaa     1440

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa     1500

ugcauccccc cccccccccc cccccccccc ccccccaaag gcucuuuuca gagccaccag     1560

aauu                                                                  1564


<210>  949
<211>  1564
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Ipilimumab HC without signale peptide

<400>  949
gggagaaagc uuacccaagu ccagcuaguc gaaucaggcg gaggcgucgu ccaacccgga       60

cggucccuac gacucagcug ugcugccagc ggcuucaccu ucucguccua cacaaugcac      120

uggguccggc aagcacccgg caaaggucuc gaauggguca ccuucauauc cuaugacggc      180

aacaacaaau acuacgccga cuccgucaaa ggccgcuuca caaucucaag agacaacucc      240

aaaaacaccc ucuaccucca aaugaacucg cuaagagcag aagacaccgc caucuacuac      300

ugcgcccgca ccggauggcu cggccccuuc gacuacuggg gccaaggcac ccuagucaca      360

guaucauccg ccucuacaaa gggaccaucc gucuuccccc ucgccccauc cuccaaaucc      420

accucuggag gcaccgccgc acucggaugc cucgucaaag acuacuuccc cgaacccguc      480

acagucuccu ggaacuccgg cgcccuaacc uccggagucc acacauuccc ugcuguccua      540

caauccucgg gccuauacuc ccucucaucu guagucaccg uccccucauc cucccuugga      600

acccaaacgu acauaugcaa cgucaaccac aaaccuucca acacaaaagu cgacaaacgu      660

guagagccaa aguccuguga caaaacacac acaugcccac caugucccgc gcccgaacua      720

cucggcggac ccucagucuu ccucuuuccc ccgaaaccca aagacacccu caugauauca      780

cgcacccccg aaguuaccug cgucgucguc gacgucuccc acgaagaccc cgaagucaaa      840

uucaacuggu acgucgacgg cguagaaguc cacaacgcca aaaccaaacc acgggaagaa      900

caauacaacu ccacauaccg cgucgucagc guacucaccg uccuacauca agacuggcua      960

aacggcaaag aauacaaaug caaaguaucc aacaaagcac ucccagcacc aaucgagaaa     1020

acaaucucaa aagcaaaagg ccaaccccgg gaaccacaag uauauacccu cccacccagc     1080

agagacgaac ucaccaaaaa ccaaguuuca cucacaugcc ucguaaaagg auucuacccc     1140

ucugacauug cugucgaaug ggaauccaac ggacaacccg aaaacaacua caaaaccacc     1200

ccgcccgucc ucgacuccga cggcucauuc uuccuauacu ccaaacucac cguagacaaa     1260

ucccgauggc agcaaggcaa cgucuucucc ugcagcguaa ugcacgaagc acuccacaac     1320

cacuauaccc aaaaaucccu cucccugucc cccggaaagu aaggacuagu uauaagacug     1380

acuagcccga ugggccuccc aacgggcccu ccuccccucc uugcaccgag auuaauaaaa     1440

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa     1500

ugcauccccc cccccccccc cccccccccc ccccccaaag gcucuuuuca gagccaccag     1560

aauu                                                                  1564


<210>  950
<211>  1564
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Ipilimumab HC without signale peptide

<400>  950
gggagaaagc uuacccaagu acaacucguc gaauccggcg gcggcguagu ccaaccaggc       60

agaucccuac gccucuccug cgccgcaucc ggauucaccu ucuccuccua caccaugcac      120

uggguacgcc aagcccccgg caagggccuc gaauggguca cguucaucuc uuacgacggc      180

aacaacaaau acuacgccga cuccguaaaa ggucguuuca ccaucucccg cgacaacagc      240

aaaaacaccc uauaccuuca aaugaacucc cuccgcgccg aagacaccgc caucuacuac      300

ugugcccgca ccgguuggcu cggccccuuc gacuacuggg gucaaggaac ccuaguuacc      360

guaucauccg caucuaccaa aggccccucc guauucccac uagccccauc guccaaauca      420

acaucaggcg gcacagccgc ccucggaugc cuagucaaag acuacuuccc cgaacccguc      480

accgucucau ggaacuccgg agcccuaacc ucgggagucc acaccuuccc agcgguacua      540

caaucauccg gacuuuacuc ccuaucaucc gucgucacag uaccauccuc aucccucggg      600

acccaaaccu acauaugcaa cgucaaccac aaaccaucca acaccaaagu cgacaaaaga      660

gucgaaccaa aauccugcga caaaacccac acaugcccac ccugcccagc ccccgaacuc      720

cucggcggcc ccuccguauu ccucuuccca cccaaaccca aggacacccu caugauaucc      780

cgcaccccag aaguaaccug cguaguaguc gacguuucac acgaagaccc cgaagucaaa      840

uucaacuggu acguagacgg cgucgagguc cacaacgcca aaaccaaacc ucgcgaagaa      900

caauacaaca gcacauaccg cgucgucucc guccuaaccg uacuacacca agacuggcua      960

aacggcaaag aauacaagug caaagucucc aacaaagccc uccccgcccc caucgagaaa     1020

accauaucca aagccaaagg ucaaccccgc gaaccccaag uauacacccu acccccaucc     1080

cgcgacgagc ucaccaaaaa ccaaguaucc cuaaccugcc ucgucaaagg cuucuacccc     1140

uccgacauag ccgucgaaug ggaaagcaau ggccagcccg aaaacaacua caaaacaacc     1200

ccacccgucc ucgacuccga cggcucuuuc uuccucuacu caaaacucac agucgacaaa     1260

ucacgauggc aacaaggcaa cgucuucucc ugcagcguaa ugcacgaagc ccuccacaac     1320

cacuacaccc aaaaaucacu cagccuaagc cccggcaagu aaggacuagu uauaagacug     1380

acuagcccga ugggccuccc aacgggcccu ccuccccucc uugcaccgag auuaauaaaa     1440

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa     1500

ugcauccccc cccccccccc cccccccccc ccccccaaag gcucuuuuca gagccaccag     1560

aauu                                                                  1564


<210>  951
<211>  1564
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Ipilimumab HC without signale peptide

<400>  951
gggagaaagc uuacccaagu ccaacuaguc gaaucaggag gaggcguagu acaaccagga       60

agauccuuaa gacuuucaug ugcagcaucu ggauuuaccu ucucaucaua cacaaugcac      120

ugggucagac aagcccccgg aaaaggacua gaauggguaa cauuuauauc auaugaugga      180

aauaacaaau auuacgcaga uucuguaaaa ggaagauuca ccaucucaag agauaauuca      240

aaaaacacac uauaccuaca aaugaacuca cucagagcug aagacaccgc aauauacuau      300

ugcgcaagaa caggaugguu aggaccuuuc gauuacuggg gacaaggaac acuaguuacc      360

gucuccuccg caaguaccaa aggaccaucu guauucccau uagcaccauc auccaaauca      420

acaucaggag gaaccgcagc auuaggaugc uuaguaaaag acuacuuucc ugaacccgua      480

acaguaucau ggaauuccgg agcacuaaca ucaggaguac auaccuuucc agcaguacuc      540

caaucaucag gauuauauuc cuuaucuuca guaguaacag ucccaucauc uucacuaggu      600

acacaaaccu acaucugcaa uguaaaccac aaaccaucaa auacaaaagu cgacaaaaga      660

guugaaccaa aaucauguga caaaacucac acaugcccac cauguccagc cccagaauua      720

cuaggaggac caucaguauu ccuuuuccca ccaaaaccaa aagauacucu aaugauaucc      780

cguaccccag aaguaacaug cgucguagua gacguaucac acgaagaccc cgaaguaaaa      840

uucaauuggu acgucgacgg aguagaagua cacaacgcca aaacaaaacc ccgagaagaa      900

caauacaacu ccacauaccg uguaguauca guauuaacag ucuuacacca agacuggcua      960

aacggaaaag aauacaaaug uaaaguuucc aacaaagcac ucccagcccc uaucgaaaaa     1020

accauaucaa aagcaaaagg ccaacccaga gaaccccaag uuuauacacu accaccauca     1080

agagacgaau uaacaaaaaa ccaaguaucc cuaacaugcc uaguaaaagg auucuacccu     1140

ucagacaucg caguagaaug ggaauccaac ggacaaccug aaaacaacua uaaaacaaca     1200

ccaccaguau uagauagcga uggaucuuuc uucuuauauu caaaacuuac aguagacaaa     1260

ucucgauggc aacaaggaaa cguauucuca ugcuccguaa ugcacgaagc gcuacauaac     1320

cauuacacac aaaaaucacu aucauuauca ccaggaaaau aaggacuagu uauaagacug     1380

acuagcccga ugggccuccc aacgggcccu ccuccccucc uugcaccgag auuaauaaaa     1440

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa     1500

ugcauccccc cccccccccc cccccccccc ccccccaaag gcucuuuuca gagccaccag     1560

aauu                                                                  1564


<210>  952
<211>  1564
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Ipilimumab HC without signale peptide

<400>  952
gggagaaagc uuacccaagu ucaauuagua gaaucuggag gaggaguagu ccaaccagga       60

cguucacuaa gacucucuug ugcagcuuca ggauuuacgu ucucaagcua uaccaugcac      120

uggguaagac aagccccagg aaaaggauua gaauggguaa cauuuauauc uuacgacggc      180

aauaacaaau auuaugcaga cucaguuaaa gguagauuca caauaagccg agacaauuca      240

aaaaacacuc uauaucuaca aaugaauagc cuaagagcag aagauacagc aauauauuac      300

ugugcacgua caggaugguu agguccuuuc gauuacuggg gacaagguac ucuaguuaca      360

guaagcagcg caucuaccaa aggaccaagc guauucccuc uugcuccauc aagcaaaucc      420

acaucaggcg gaacagcugc auuaggaugc uuaguaaaag acuauuuccc agaacccgua      480

acgguaucuu ggaacagcgg cgcauuaaca ucaggaguac auacuuuucc ugcaguacua      540

caaagcuccg gauuauacuc uuuaucauca guaguaacag uaccauccuc aucacuagga      600

acacaaacau auauauguaa cguaaaucau aaaccaucaa acaccaaagu agacaaaaga      660

guagaaccaa aaucauguga uaaaacucac accuguccuc cauguccagc acccgaauua      720

uuaggagguc caaguguauu cuuauuucca ccaaaaccua aagauacccu aaugauauca      780

agaacaccag aaguaacaug uguaguagua gacgucucac acgaagaccc agaaguaaaa      840

uucaacuggu acguagacgg aguagaagua cauaacgcua aaacuaaacc acgagaagaa      900

caauacaaua guacauacag aguaguguca guauuaacag uauuacacca agacuggcua      960

aauggaaaag aauacaaaug uaaaguauca aauaaagcac uaccagcacc aaucgaaaaa     1020

accaucucca aagccaaagg acaaccccgu gaaccucaag ucuauacccu accacccuca     1080

agagacgaac uuacaaaaaa ccaaguaagc uuaacauguc uaguaaaagg auucuaucca     1140

uccgacauag caguagaaug ggaaucaaau ggucaaccag aaaacaacua caaaacaaca     1200

ccaccaguuc ucgauucaga uggaucauuu uuucuauaua gcaaauuaac uguagacaaa     1260

ucuagauggc aacaaggaaa uguauucuca uguucaguaa ugcaugaagc acuccacaau     1320

cauuacacac aaaaaaguuu aaguuuaucc ccaggcaaau aaggacuagu uauaagacug     1380

acuagcccga ugggccuccc aacgggcccu ccuccccucc uugcaccgag auuaauaaaa     1440

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa     1500

ugcauccccc cccccccccc cccccccccc ccccccaaag gcucuuuuca gagccaccag     1560

aauu                                                                  1564


<210>  953
<211>  1564
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Ipilimumab backbone Rituximab HC without signale peptide

<400>  953
gggagaaagc uuacccaggu gcagcugguc gagagcggcg ggggcguggu gcagcccggg       60

cgcucccucc ggcugagcug cgccgccucc ggcuucaccu ucagcuccua caccaugcac      120

uggguccgcc aggcgccggg gaagggccug gaguggguga cguucaucag cuacgacggc      180

aacaacaagu acuacgccga cuccgugaag gggcgguuca ccaucagccg cgacaacucc      240

aagaacaccc ucuaccugca gaugaacagc cugcgggccg aggacaccgc caucuacuac      300

ugcgcccgca cgggcuggcu cgggcccuuc gacuacuggg gccaggggac ccuggucacc      360

guguccagcg cguccaccaa gggccccagc guguuccccc uggccccguc cagcaagucc      420

acgagcggcg ggaccgccgc ccucggcugc cuggucaagg acuacuuccc cgagcccgug      480

accguguccu ggaacagcgg ggcgcugacc agcggcgucc acacguuccc cgccgugcuc      540

caguccagcg gccuguacuc ccugagcucc guggucaccg ugccgagcuc cagccucggg      600

acccagaccu acaucugcaa cgugaaccac aagcccucca acacgaaggu cgacaagcgg      660

guggagccca agagcugcga caagacccac acgugcccgc ccugccccgc ccccgagcug      720

cugggcggcc cgagcguguu ccucuucccg cccaagccca aggacacccu gaugaucagc      780

cgcacccccg aggucacgug cguggugguc gacgugagcc acgaggaccc cgaggugaag      840

uucaacuggu acgucgacgg gguggaggug cacaacgcca agaccaagcc ccgggaggag      900

caguacaaca gcaccuaccg cgucgugagc gugcugaccg uccuccacca ggacuggcug      960

aacggcaagg aguacaagug caaggugucg aacaaggccc ugccggcccc caucgagaag     1020

acgaucagca aggcgaaggg ccagccgcgg gagccccagg ucuacacccu cccgcccagc     1080

cgcgacgagc ugaccaagaa ccaggugucc cugacgugcc ucgugaaggg cuucuacccc     1140

agcgacaucg ccgucgagug ggagagcaac gggcagcccg agaacaacua caagaccacg     1200

cccccggugc uggacuccga cggcagcuuc uuccuguacu ccaagcucac cguggacaag     1260

agccgguggc agcaggggaa cgucuucucc ugcagcguga ugcacgaggc ccugcacaac     1320

cacuacaccc agaagucccu gagccucucc cccggcaagu gaggacuagu uauaagacug     1380

acuagcccga ugggccuccc aacgggcccu ccuccccucc uugcaccgag auuaauaaaa     1440

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa     1500

ugcauccccc cccccccccc cccccccccc ccccccaaag gcucuuuuca gagccaccag     1560

aauu                                                                  1564


<210>  954
<211>  1564
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Ipilimumab backbone Rituximab HC without signale peptide

<400>  954
gggagaaagc uuacccaggu gcaacugguc gagagcggcg ggggaguugu gcagcccggu       60

agaucccuca ggcuuucuug cgccgcuuca ggcuucaccu uuaguagcua cacaaugcac      120

uggguacggc aggcaccugg gaagggacug gaauggguga cuuucaucuc cuaugacggc      180

aacaauaaau acuaugccga uucugucaag ggucgcuuua cgauuucgcg agacaacagc      240

aaaaauaccu uguacuuaca gaugaacuca cugcgugcgg aggauacagc uauauauuac      300

ugugccagaa cuggguggcu aggaccauuc gacuauuggg gccaaggcac ccucgugaca      360

guuaguuccg caucuaccaa ggggccgagc guguuucccc uggccccuuc cucaaaaagu      420

acuagcggag guacagcugc acuuggcugc cuggucaagg auuacuuccc agaacccgug      480

accguaucuu ggaacuccgg ggccuugacg ucaggaguuc auacuuuucc ugcugugcuc      540

cagagcagug gccuguacuc ucuguccagc gucgugaccg ugccaucguc uucccucggu      600

acacagacuu auaucuguaa ugucaaucac aagcccucaa acaccaaagu ugacaagagg      660

guggagccua aaaguugcga uaagacacau accuguccac cgugccccgc ccccgagcug      720

cugggcggcc cgagcguguu ccucuucccg cccaagccca aggacacccu gaugaucagc      780

cgcacccccg aggucacgug cguggugguc gacgugagcc acgaggaccc cgaggugaag      840

uucaacuggu acgucgacgg gguggaggug cacaacgcca agaccaagcc ccgggaggag      900

caguacaaca gcaccuaccg cgucgugagc gugcugaccg uccuccacca ggacuggcug      960

aacggcaagg aguacaagug caaggugucg aacaaggccc ugccggcccc caucgagaag     1020

acgaucagca aggcgaaggg gcagccuagg gagccccagg uuuacacgcu uccacccagc     1080

cgggaugaac ugaccaaaaa ccaggugucu uugacauguc ucguaaaggg auuuuauccu     1140

ucagacaucg ccgucgagug ggaaaguaau ggucaaccag agaacaacua caaaacuacc     1200

ccgcccgugc uggacagcga uggcuccuuc uuuuuauacu cuaagcugac aguugacaaa     1260

ucgcgcuggc agcaggggaa uguguucagc ugcuccguca ugcacgaggc acuccauaac     1320

cacuauacuc aaaagucacu uagucugucu ccuggaaagu gaggacuagu uauaagacug     1380

acuagcccga ugggccuccc aacgggcccu ccuccccucc uugcaccgag auuaauaaaa     1440

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa     1500

ugcauccccc cccccccccc cccccccccc ccccccaaag gcucuuuuca gagccaccag     1560

aauu                                                                  1564


<210>  955
<211>  1564
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Ipilimumab backbone Rituximab HC without signale peptide

<400>  955
gggagaaagc uuacccaggu gcagcuggug gagagcggcg gcggcguggu gcagcccggc       60

agaagccuga gacugagcug cgccgccagc ggcuucaccu ucagcagcua caccaugcac      120

ugggugagac aggcccccgg caagggccug gaguggguga ccuucaucag cuacgacggc      180

aacaacaagu acuacgccga cagcgugaag ggcagauuca ccaucagcag agacaacagc      240

aagaacaccc uguaccugca gaugaacagc cugagagccg aggacaccgc caucuacuac      300

ugcgccagaa ccggcuggcu gggccccuuc gacuacuggg gccagggcac ccuggugacc      360

gugagcagcg ccagcaccaa gggccccagc guguuccccc uggcccccag cagcaagagc      420

accagcggcg gcaccgccgc ccugggcugc cuggugaagg acuacuuccc cgagcccgug      480

accgugagcu ggaacagcgg cgcccugacc agcggcgugc acaccuuccc cgccgugcug      540

cagagcagcg gccuguacag ccugagcagc guggugaccg ugcccagcag cagccugggc      600

acccagaccu acaucugcaa cgugaaccac aagcccagca acaccaaggu ggacaagaga      660

guggagccca agagcugcga caagacccac accugccccc ccugccccgc ccccgagcug      720

cugggcggcc cgagcguguu ccucuucccg cccaagccca aggacacccu gaugaucagc      780

cgcacccccg aggucacgug cguggugguc gacgugagcc acgaggaccc cgaggugaag      840

uucaacuggu acgucgacgg gguggaggug cacaacgcca agaccaagcc ccgggaggag      900

caguacaaca gcaccuaccg cgucgugagc gugcugaccg uccuccacca ggacuggcug      960

aacggcaagg aguacaagug caaggugucg aacaaggccc ugccggcccc caucgagaag     1020

acgaucagca aggcgaaggg ccagcccaga gagccccagg uguacacccu gccccccagc     1080

agagacgagc ugaccaagaa ccaggugagc cugaccugcc uggugaaggg cuucuacccc     1140

agcgacaucg ccguggagug ggagagcaac ggccagcccg agaacaacua caagaccacc     1200

ccccccgugc uggacagcga cggcagcuuc uuccuguaca gcaagcugac cguggacaag     1260

agcagauggc agcagggcaa cguguucagc ugcagcguga ugcacgaggc ccugcacaac     1320

cacuacaccc agaagagccu gagccugagc cccggcaagu gaggacuagu uauaagacug     1380

acuagcccga ugggccuccc aacgggcccu ccuccccucc uugcaccgag auuaauaaaa     1440

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa     1500

ugcauccccc cccccccccc cccccccccc ccccccaaag gcucuuuuca gagccaccag     1560

aauu                                                                  1564


<210>  956
<211>  925
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Ipilimumab LC with signale peptide

<400>  956
gggagaaagc uuaccaugga gacccccgcc cagcugcucu uccugcugcu ccuguggcug       60

ccggacacca cgggcgagau cgugcugacc cagagccccg gcacccucuc ccugagcccg      120

ggggagcgcg ccacgcuguc cugccgggcc agccaguccg ucggcagcuc cuaccucgcg      180

ugguaccagc agaagcccgg gcaggcgccc cgccugcuga ucuacggcgc cuucagccgg      240

gccaccggga uccccgaccg cuucuccggc agcggcuccg ggaccgacuu cacccucacg      300

aucagccggc uggagccgga ggacuucgcc guguacuacu gccagcagua cggcuccagc      360

cccuggaccu ucgggcaggg caccaaggug gagaucaagc gcaccgucgc cgcccccucc      420

guguucaucu ucccgcccag cgacgagcag cugaaguccg ggacggccag cguggucugc      480

cuccugaaca acuucuaccc ccgggaggcc aaggugcagu ggaaggugga caacgcgcug      540

caguccggca acagccagga gagcgucacc gagcaggacu ccaaggacag caccuacucc      600

cucagcucca cccugacgcu gagcaaggcc gacuacgaga agcacaaggu guacgccugc      660

gaggugaccc accagggccu cuccagcccc gucaccaagu ccuucaaccg cggggagugc      720

ugaggacuag uuauaagacu gacuagcccg augggccucc caacgggccc uccuccccuc      780

cuugcaccga gauuaauaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa      840

aaaaaaaaaa aaaaaaaaaa augcaucccc cccccccccc cccccccccc cccccccaaa      900

ggcucuuuuc agagccacca gaauu                                            925


<210>  957
<211>  925
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Ipilimumab LC with signale peptide

<400>  957
gggagaaagc uuaccaugga gacccccgcc cagcuccucu uccuccuccu ccucuggcuc       60

cccgacacca ccggcgagau cguccucacc cagucccccg gcacccucuc ccucuccccc      120

ggcgagcgcg ccacccucuc cugccgcgcc ucccaguccg ucggcuccuc cuaccucgcc      180

ugguaccagc agaagcccgg ccaggccccc cgccuccuca ucuacggcgc cuucucccgc      240

gccaccggca uccccgaccg cuucuccggc uccggcuccg gcaccgacuu cacccucacc      300

aucucccgcc ucgagcccga ggacuucgcc gucuacuacu gccagcagua cggcuccucc      360

cccuggaccu ucggccaggg caccaagguc gagaucaagc gcaccgucgc cgcccccucc      420

gucuucaucu ucccccccuc cgacgagcag cucaaguccg gcaccgccuc cgucgucugc      480

cuccucaaca acuucuaccc ccgcgaggcc aagguccagu ggaaggucga caacgcccuc      540

caguccggca acucccagga guccgucacc gagcaggacu ccaaggacuc caccuacucc      600

cucuccucca cccucacccu cuccaaggcc gacuacgaga agcacaaggu cuacgccugc      660

gaggucaccc accagggccu cuccuccccc gucaccaagu ccuucaaccg cggcgagugc      720

ugaggacuag uuauaagacu gacuagcccg augggccucc caacgggccc uccuccccuc      780

cuugcaccga gauuaauaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa      840

aaaaaaaaaa aaaaaaaaaa augcaucccc cccccccccc cccccccccc cccccccaaa      900

ggcucuuuuc agagccacca gaauu                                            925


<210>  958
<211>  925
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Ipilimumab LC with signale peptide

<400>  958
gggagaaagc uuaccaugga gacccccgcc cagcuucucu uccuucuguu guuauggcug       60

ccugacacaa cuggcgaaau cgugcuaacg caaagcccag ggacccucuc ccugucuccg      120

ggagagagag cuacacuuuc augcagggca agucagagcg ucgguuccuc uuaccuggcc      180

ugguaucagc agaagcccgg ccaagcgccu cgguugcuca uuuacggggc uuuuucgcgc      240

gccacuggaa uaccagaucg auucucaggc agcgguagug ggaccgacuu uacacugacc      300

aucucccguc uggaacccga ggauuucgca guuuauuacu gucagcagua uggaucuagc      360

ccuuggacuu uuggccaggg cacaaaagug gaaauuaaga gaaccguagc cgcuccaucc      420

guguucaucu uucccccuuc agacgagcaa cucaaaagug ggacggcaag cgucgugugc      480

uuacugaaca auuucuaccc aagggaggcc aagguucagu ggaaagugga uaacgcucug      540

cagucuggaa auucccagga aucagucacu gagcaagaca gcaaggauag uaccuauucu      600

uuguccagca cacugacucu aucgaaggcc gacuacgaaa aacacaaggu guacgcgugu      660

gagguaaccc aucagggucu cucuuccccg guuacaaaau cauuuaaccg gggcgagugc      720

ugaggacuag uuauaagacu gacuagcccg augggccucc caacgggccc uccuccccuc      780

cuugcaccga gauuaauaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa      840

aaaaaaaaaa aaaaaaaaaa augcaucccc cccccccccc cccccccccc cccccccaaa      900

ggcucuuuuc agagccacca gaauu                                            925


<210>  959
<211>  925
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Ipilimumab LC with signale peptide

<400>  959
gggagaaagc uuaccaugga gacccccgcc cagcugcugu uccugcugcu gcuguggcug       60

cccgacacca ccggcgagau cgugcugacc cagagccccg gcacccugag ccugagcccc      120

ggcgagagag ccacccugag cugcagagcc agccagagcg ugggcagcag cuaccuggcc      180

ugguaccagc agaagcccgg ccaggccccc agacugcuga ucuacggcgc cuucagcaga      240

gccaccggca uccccgacag auucagcggc agcggcagcg gcaccgacuu cacccugacc      300

aucagcagac uggagcccga ggacuucgcc guguacuacu gccagcagua cggcagcagc      360

cccuggaccu ucggccaggg caccaaggug gagaucaaga gaaccguggc cgcccccagc      420

guguucaucu ucccccccag cgacgagcag cugaagagcg gcaccgccag cguggugugc      480

cugcugaaca acuucuaccc cagagaggcc aaggugcagu ggaaggugga caacgcccug      540

cagagcggca acagccagga gagcgugacc gagcaggaca gcaaggacag caccuacagc      600

cugagcagca cccugacccu gagcaaggcc gacuacgaga agcacaaggu guacgccugc      660

gaggugaccc accagggccu gagcagcccc gugaccaaga gcuucaacag aggcgagugc      720

ugaggacuag uuauaagacu gacuagcccg augggccucc caacgggccc uccuccccuc      780

cuugcaccga gauuaauaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa      840

aaaaaaaaaa aaaaaaaaaa augcaucccc cccccccccc cccccccccc cccccccaaa      900

ggcucuuuuc agagccacca gaauu                                            925


<210>  960
<211>  925
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Ipilimumab LC with signale peptide

<400>  960
gggagaaagc uuaccaugga gacccccgcc cagcuccugu uccugcuucu gcucuggcug       60

ccugacacaa cgggcgaaau cgugcuuacc caaagcccgg ggacacuguc ccucucuccc      120

ggagagagag cuacccugag cugccgggcc ucccagucug ucggcagcuc cuaccuggcg      180

ugguaucagc agaaaccugg gcaagcuccc cgccuccuga uuuacggagc cuuuucuaga      240

gccacaggca ucccugaucg guucagcggg uccggaagcg gcaccgacuu uacacuuacc      300

auuucucgcc uggaacccga ggauuucgcu guuuauuacu gucagcagua uggcuccagc      360

ccuuggacgu uugggcaggg aaccaaagug gaaaucaaga gaacaguggc cgcuccgucu      420

gucuucauuu uucccccuuc cgacgagcaa cucaaaagcg gcaccgccuc ugugguuugc      480

cugcuuaaca auuucuaccc ccgggaggcg aaggugcagu ggaaagucga uaacgcccug      540

caguccggga auagccagga auccgugaca gagcaagacu cuaaggauag caccuauucc      600

cucagcucua cgcugacacu guccaaggcu gacuacgaaa aacacaaggu uuacgccugu      660

gaggugaccc aucagggacu cagcucuccu gucacaaaga gcuuuaaccg cggcgagugc      720

ugaggacuag uuauaagacu gacuagcccg augggccucc caacgggccc uccuccccuc      780

cuugcaccga gauuaauaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa      840

aaaaaaaaaa aaaaaaaaaa augcaucccc cccccccccc cccccccccc cccccccaaa      900

ggcucuuuuc agagccacca gaauu                                            925


<210>  961
<211>  925
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Ipilimumab LC with signale peptide

<400>  961
gggagaaagc uuaccaugga aacaccagca caacuacuau ucuuacuauu acuauggcua       60

ccagacacaa caggagaaau aguacuaaca caaucaccag gaacacuaag ucuaucacca      120

ggagaaagag caacacuauc augcagagca ucccaaucag uuggaucuuc cuaccuagcc      180

ugguaucaac aaaaaccagg acaagcacca agauuacuaa uauacggagc auucucaaga      240

gcaacuggaa ucccagauag auucucagga ucaggaucag gaacagacuu cacauuaaca      300

auaucacgac uagaaccaga agacuucgca guauacuacu gucaacaaua cggauccuca      360

ccauggaccu ucggccaagg aacaaaagua gaaauaaaaa gaacaguagc agccccaucu      420

guauucauau ucccaccauc agaugaacaa cuaaaaucag gaacagcauc aguaguaugc      480

uuacuaaaca acuucuaccc aagagaagcc aaaguacaau ggaaaguaga caacgcacua      540

caaucaggaa auucccaaga aucaguaaca gaacaagacu caaaagacuc cacauacuca      600

uuaucaucaa cauuaacacu aucaaaagca gacuacgaaa aacacaaagu auacgcaugu      660

gaaguaacac accaaggacu aucaucacca guaacaaaau cauucaaccg aggagaaugc      720

ugaggacuag uuauaagacu gacuagcccg augggccucc caacgggccc uccuccccuc      780

cuugcaccga gauuaauaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa      840

aaaaaaaaaa aaaaaaaaaa augcaucccc cccccccccc cccccccccc cccccccaaa      900

ggcucuuuuc agagccacca gaauu                                            925


<210>  962
<211>  925
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Ipilimumab LC with signale peptide

<400>  962
gggagaaagc uuaccaugga gacccccgcc cagcuccugu uccuguugcu gcucuggcug       60

ccagacacua ccggcgaaau cguguugacg caaagcccgg ggacucuguc ccucaguccc      120

ggugagaggg caacccugag cugccgggcc ucccagagug ucggcagcuc cuaccuggcg      180

ugguaucagc agaagccagg gcaagcaccc cgccuccuga uuuacggcgc cuuuagcagg      240

gccaccggua ucccagaucg guucuccggg aguggcagcg gcacugacuu uaccuugacg      300

auuucccgcc uggaacccga ggauuucgca guguauuacu gucagcagua ugggagcagu      360

ccauggacuu uuggucaggg caccaaagua gaaaucaaga ggacuguggc cgcgccgucc      420

gucuucauuu uucccccaag cgacgagcaa cucaaauccg ggaccgccag uguggugugc      480

cugcugaaca auuucuaccc ccgggaggca aagguccagu ggaaagugga uaacgccuug      540

cagagcggca auucccagga aagcguaacc gagcaagaca guaaggauuc cacguauagc      600

cucaguucca cucugacccu gagcaaggcc gacuacgaaa aacacaaggu guacgcaugu      660

gaggucacuc aucagggucu cagcucccca gugaccaaaa guuuuaaccg cggggagugc      720

ugaggacuag uuauaagacu gacuagcccg augggccucc caacgggccc uccuccccuc      780

cuugcaccga gauuaauaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa      840

aaaaaaaaaa aaaaaaaaaa augcaucccc cccccccccc cccccccccc cccccccaaa      900

ggcucuuuuc agagccacca gaauu                                            925


<210>  963
<211>  925
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Ipilimumab LC with signale peptide

<400>  963
gggagaaagc uuaccaugga aacccccgcc caacuccucu uccuauuacu ccucuggcua       60

cccgacacca ccggcgaaau cguccucacc caauccccag gcacccucuc ucucuccccc      120

ggagaacgcg caacacucuc cugccgugca ucccaauccg ucggaucuuc cuaccucgcc      180

ugguaccaac aaaaacccgg ccaagcccca cgccuccuca ucuacggcgc cuucucccgc      240

gccaccggca uuccagaccg uuucucagga uccggcuccg gcaccgauuu cacacucacc      300

aucucccgcc uagaaccaga agacuucgcc guauacuacu gccagcaaua cggaucuucc      360

cccuggacau ucggccaagg caccaaaguc gaaaucaaac gcaccgucgc agcccccucc      420

gucuucaucu ucccacccuc cgacgaacaa cuaaaaucug gcacagcauc cgucgucugc      480

cuccuaaaca acuucuaccc ccgcgaagcc aaaguccaau ggaaagucga caacgcacuc      540

caaucuggca acucacaaga auccgucaca gaacaagacu ccaaagacuc aaccuacucc      600

cucuccucaa cccucacccu cuccaaagcc gacuacgaaa aacacaaggu cuacgcaugc      660

gaagucaccc aucaaggacu cuccuccccc gucaccaaau ccuucaaccg cggcgaaugc      720

uaaggacuag uuauaagacu gacuagcccg augggccucc caacgggccc uccuccccuc      780

cuugcaccga gauuaauaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa      840

aaaaaaaaaa aaaaaaaaaa augcaucccc cccccccccc cccccccccc cccccccaaa      900

ggcucuuuuc agagccacca gaauu                                            925


<210>  964
<211>  925
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Ipilimumab LC with signale peptide

<400>  964
gggagaaagc uuaccaugga aacacccgcc caacuccucu uccuccuccu ccucuggcua       60

cccgacacca ccggcgaaau cguccucacc caaucccccg gcacccuauc ccucuccccc      120

ggcgaacgcg ccacccuauc cugccgcgca ucccaauccg uaggauccuc cuaccucgcc      180

ugguaccaac aaaaacccgg ccaagcaccc cgccuccuca ucuacggagc cuucucccgc      240

gccaccggca ucccugaccg cuucuccggc ucaggcucag gcaccgacuu cacccucacc      300

aucucucgcc uagaacccga agacuucgcc guauacuauu gccaacaaua cggcuccucc      360

ccuuggaccu ucggccaagg aacaaaaguc gaaaucaaac gaaccgucgc cgcccccuca      420

gucuucaucu ucccacccuc cgacgaacaa cucaaauccg guaccgccuc cgucgucugc      480

cuucucaaca acuucuaccc ccgagaagcc aaaguacaau ggaaagucga caacgcacua      540

caaucaggca acucccaaga auccgucacc gaacaagauu ccaaagacuc aaccuacuca      600

cucuccucca cacucacccu cuccaaagcc gacuacgaaa aacacaaagu cuacgccugc      660

gaagucaccc accaaggacu cuccagcccc gucaccaaau ccuucaaccg cggcgaaugc      720

uaaggacuag uuauaagacu gacuagcccg augggccucc caacgggccc uccuccccuc      780

cuugcaccga gauuaauaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa      840

aaaaaaaaaa aaaaaaaaaa augcaucccc cccccccccc cccccccccc cccccccaaa      900

ggcucuuuuc agagccacca gaauu                                            925


<210>  965
<211>  925
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Ipilimumab LC with signale peptide

<400>  965
gggagaaagc uuaccaugga aacucccgcc caacuacucu uccuccuccu ccucuggcuc       60

cccgacacca ccggcgaaau cguccuuacc cagucccccg gcacccucuc acucuccccc      120

ggcgaacgcg ccacccuauc cugucgcgcc ucccaaucag ucggcucauc auaccucgcc      180

ugguaccaac aaaaacccgg ccaagccccu cgccuccuca uauacggcgc cuucucccgc      240

gccaccggca uccccgaccg auucuccggc uccggcuccg gcacugacuu cacccucacc      300

auaucccgcc ucgaacccga agacuucgca gucuacuacu gccaacaaua cggaucuucc      360

cccuggaccu ucggccaagg caccaaaguc gaaaucaaac gcaccgucgc cgcccccucc      420

gucuucauau ucccacccuc agacgaacaa cucaaaucag gcaccgcauc cgucgucugc      480

cuccucaaca acuucuaccc ccgcgaagcc aaaguccaau ggaaagucga caacgcccuc      540

caaucaggca acucacaaga auccgucaca gaacaagacu ccaaagacuc aaccuacucc      600

cucuccucaa cccucacacu cuccaaagcc gacuacgaaa aacacaaagu cuacgccugc      660

gaagucaccc accaaggacu uuccucaccc gucaccaaau ccuucaaccg cggcgaaugc      720

uaaggacuag uuauaagacu gacuagcccg augggccucc caacgggccc uccuccccuc      780

cuugcaccga gauuaauaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa      840

aaaaaaaaaa aaaaaaaaaa augcaucccc cccccccccc cccccccccc cccccccaaa      900

ggcucuuuuc agagccacca gaauu                                            925


<210>  966
<211>  925
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Ipilimumab LC with signale peptide

<400>  966
gggagaaagc uuaccaugga aacaccagca caacuauuau uccuauuacu ucuauggcua       60

ccagacacaa caggagaaau aguauuaaca caaagcccag gaacacucuc auuaucacca      120

ggagaaagag caacacucuc augccgagca ucccaauccg ucggaucauc auaucuagca      180

ugguaccaac aaaaaccagg acaagcaccc agacuacuaa uauacggagc auuuucaaga      240

gccacaggaa ucccagacag auuuucagga ucaggaucag gaacagacuu cacauuaaca      300

auaucacgau uagaacccga agacuucgca guauacuacu gccaacaaua cggaucaucu      360

cccuggacau ucggacaagg cacaaaagua gaaauaaaac gaacagucgc agcaccauca      420

guauucauau ucccaccauc agacgaacaa cuaaaaucag gaacagcauc aguaguaugc      480

cuauuaaaua acuucuaccc aagagaagca aaaguccaau ggaaaguaga uaacgcacua      540

caaucaggaa acucucaaga aucaguaacc gaacaagacu caaaagauuc aaccuacuca      600

uuaucaucaa cauuaacacu aucaaaagca gacuacgaaa aacacaaagu auacgcaugc      660

gaaguaaccc accaaggccu aucaucacca guaacaaaau cauucaacag aggagaaugc      720

ugaggacuag uuauaagacu gacuagcccg augggccucc caacgggccc uccuccccuc      780

cuugcaccga gauuaauaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa      840

aaaaaaaaaa aaaaaaaaaa augcaucccc cccccccccc cccccccccc cccccccaaa      900

ggcucuuuuc agagccacca gaauu                                            925


<210>  967
<211>  925
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Ipilimumab LC with signale peptide

<400>  967
gggagaaagc uuaccaugga aaccccugcc caauuacuau ucuuauuauu acucuggcua       60

ccagacacaa caggagaaau aguuuuaaca caaucaccag gcacacuauc acuaucacca      120

ggagaaagag caacacuauc augcagagcc ucacaaucag ucggaucauc auaccuagca      180

ugguaucaac aaaaacccgg acaagcacca agauuauuaa uauauggagc auucucacga      240

gcaaccggaa uaccagauag auucucagga ucaggaagcg gcaccgacuu cacauuaaca      300

auaucuagac uagaaccaga agauuucgca guauacuacu gccaacaaua uggaucuuca      360

ccauggacau ucggacaagg aacaaaaguu gaaauaaaaa gaacaguagc agcaccauca      420

guauucauau ucccaccauc agacgaacaa uuaaaaucag gaacagccuc uguaguaugc      480

cuauuaaaca acuuuuaccc aagagaagca aaaguucaau ggaaaguaga caaugcacua      540

caaucaggca acucacaaga aucaguaaca gaacaagacu cuaaagacuc aacauauagc      600

cuaucaucaa cacucacccu aucaaaagca gacuacgaaa aacacaaagu auacgcaugu      660

gaaguaacac accaaggacu aucaucacca guaacaaaau cauucaacag aggagaaugc      720

uaaggacuag uuauaagacu gacuagcccg augggccucc caacgggccc uccuccccuc      780

cuugcaccga gauuaauaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa      840

aaaaaaaaaa aaaaaaaaaa augcaucccc cccccccccc cccccccccc cccccccaaa      900

ggcucuuuuc agagccacca gaauu                                            925


<210>  968
<211>  925
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Ipilimumab backbone Rituximab LC with signale peptide

<400>  968
gggagaaagc uuaccaugga gacccccgcc cagcugcucu uccugcugcu ccuguggcug       60

ccggacacca cgggcgagau cgugcugacc cagagccccg gcacccucuc ccugagcccg      120

ggggagcgcg ccacgcuguc cugccgggcc agccaguccg ucggcagcuc cuaccucgcg      180

ugguaccagc agaagcccgg gcaggcgccc cgccugcuga ucuacggcgc cuucagccgg      240

gccaccggga uccccgaccg cuucuccggc agcggcuccg ggaccgacuu cacccucacg      300

aucagccggc uggagccgga ggacuucgcc guguacuacu gccagcagua cggcuccagc      360

cccuggaccu ucgggcaggg caccaaggug gagaucaagc gcaccguggc ggcccccagc      420

guguucaucu ucccgcccag cgacgagcag cugaagagcg ggaccgccuc ggucgugugc      480

cuccugaaca acuucuaccc ccgggaggcc aaggugcagu ggaaggucga caacgcgcug      540

cagagcggca acagccagga gagcgugacg gagcaggaca gcaaggacag caccuacucg      600

cucagcagca cccugacccu gagcaaggcc gacuacgaga agcacaaggu guacgccugc      660

gaggucacgc accaggggcu cagcucgccc gugaccaaga gcuucaaccg cggggagugc      720

ugaggacuag uuauaagacu gacuagcccg augggccucc caacgggccc uccuccccuc      780

cuugcaccga gauuaauaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa      840

aaaaaaaaaa aaaaaaaaaa augcaucccc cccccccccc cccccccccc cccccccaaa      900

ggcucuuuuc agagccacca gaauu                                            925


<210>  969
<211>  925
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Ipilimumab backbone Rituximab LC with signale peptide

<400>  969
gggagaaagc uuaccaugga gacccccgcc cagcuucucu uccuucuguu guuauggcug       60

ccugacacaa cuggcgaaau cgugcuaacg caaagcccag ggacccucuc ccugucuccg      120

ggagagagag cuacacuuuc augcagggca agucagagcg ucgguuccuc uuaccuggcc      180

ugguaucagc agaagcccgg ccaagcgccu cgguugcuca uuuacggggc uuuuucgcgc      240

gccacuggaa uaccagaucg auucucaggc agcgguagug ggaccgacuu uacacugacc      300

aucucccguc uggaacccga ggauuucgca guuuauuacu gucagcagua uggaucuagc      360

ccuuggacuu uuggccaggg cacaaaagug gaaauuaaga gaaccguggc ggcccccagc      420

guguucaucu ucccgcccag cgacgagcag cugaagagcg ggaccgccuc ggucgugugc      480

cuccugaaca acuucuaccc ccgggaggcc aaggugcagu ggaaggucga caacgcgcug      540

cagagcggca acagccagga gagcgugacg gagcaggaca gcaaggacag caccuacucg      600

cucagcagca cccugacccu gagcaaggcc gacuacgaga agcacaaggu guacgccugc      660

gaggucacgc accaggggcu cagcucgccc gugaccaaga gcuucaaccg cggcgagugc      720

ugaggacuag uuauaagacu gacuagcccg augggccucc caacgggccc uccuccccuc      780

cuugcaccga gauuaauaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa      840

aaaaaaaaaa aaaaaaaaaa augcaucccc cccccccccc cccccccccc cccccccaaa      900

ggcucuuuuc agagccacca gaauu                                            925


<210>  970
<211>  925
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Ipilimumab backbone Rituximab LC with signale peptide

<400>  970
gggagaaagc uuaccaugga gacccccgcc cagcugcugu uccugcugcu gcuguggcug       60

cccgacacca ccggcgagau cgugcugacc cagagccccg gcacccugag ccugagcccc      120

ggcgagagag ccacccugag cugcagagcc agccagagcg ugggcagcag cuaccuggcc      180

ugguaccagc agaagcccgg ccaggccccc agacugcuga ucuacggcgc cuucagcaga      240

gccaccggca uccccgacag auucagcggc agcggcagcg gcaccgacuu cacccugacc      300

aucagcagac uggagcccga ggacuucgcc guguacuacu gccagcagua cggcagcagc      360

cccuggaccu ucggccaggg caccaaggug gagaucaaga gaaccguggc ggcccccagc      420

guguucaucu ucccgcccag cgacgagcag cugaagagcg ggaccgccuc ggucgugugc      480

cuccugaaca acuucuaccc ccgggaggcc aaggugcagu ggaaggucga caacgcgcug      540

cagagcggca acagccagga gagcgugacg gagcaggaca gcaaggacag caccuacucg      600

cucagcagca cccugacccu gagcaaggcc gacuacgaga agcacaaggu guacgccugc      660

gaggucacgc accaggggcu cagcucgccc gugaccaaga gcuucaaccg cggcgagugc      720

ugaggacuag uuauaagacu gacuagcccg augggccucc caacgggccc uccuccccuc      780

cuugcaccga gauuaauaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa      840

aaaaaaaaaa aaaaaaaaaa augcaucccc cccccccccc cccccccccc cccccccaaa      900

ggcucuuuuc agagccacca gaauu                                            925


<210>  971
<211>  865
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Ipilimumab LC without signale peptide

<400>  971
gggagaaagc uuaccgagau cgugcugacc cagagccccg gcacccucuc ccugagcccg       60

ggggagcgcg ccacgcuguc cugccgggcc agccaguccg ucggcagcuc cuaccucgcg      120

ugguaccagc agaagcccgg gcaggcgccc cgccugcuga ucuacggcgc cuucagccgg      180

gccaccggga uccccgaccg cuucuccggc agcggcuccg ggaccgacuu cacccucacg      240

aucagccggc uggagccgga ggacuucgcc guguacuacu gccagcagua cggcuccagc      300

cccuggaccu ucgggcaggg caccaaggug gagaucaagc gcaccgucgc cgcccccucc      360

guguucaucu ucccgcccag cgacgagcag cugaaguccg ggacggccag cguggucugc      420

cuccugaaca acuucuaccc ccgggaggcc aaggugcagu ggaaggugga caacgcgcug      480

caguccggca acagccagga gagcgucacc gagcaggacu ccaaggacag caccuacucc      540

cucagcucca cccugacgcu gagcaaggcc gacuacgaga agcacaaggu guacgccugc      600

gaggugaccc accagggccu cuccagcccc gucaccaagu ccuucaaccg cggggagugc      660

ugaggacuag uuauaagacu gacuagcccg augggccucc caacgggccc uccuccccuc      720

cuugcaccga gauuaauaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa      780

aaaaaaaaaa aaaaaaaaaa augcaucccc cccccccccc cccccccccc cccccccaaa      840

ggcucuuuuc agagccacca gaauu                                            865


<210>  972
<211>  865
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Ipilimumab LC without signale peptide

<400>  972
gggagaaagc uuaccgagau cguccucacc cagucccccg gcacccucuc ccucuccccc       60

ggcgagcgcg ccacccucuc cugccgcgcc ucccaguccg ucggcuccuc cuaccucgcc      120

ugguaccagc agaagcccgg ccaggccccc cgccuccuca ucuacggcgc cuucucccgc      180

gccaccggca uccccgaccg cuucuccggc uccggcuccg gcaccgacuu cacccucacc      240

aucucccgcc ucgagcccga ggacuucgcc gucuacuacu gccagcagua cggcuccucc      300

cccuggaccu ucggccaggg caccaagguc gagaucaagc gcaccgucgc cgcccccucc      360

gucuucaucu ucccccccuc cgacgagcag cucaaguccg gcaccgccuc cgucgucugc      420

cuccucaaca acuucuaccc ccgcgaggcc aagguccagu ggaaggucga caacgcccuc      480

caguccggca acucccagga guccgucacc gagcaggacu ccaaggacuc caccuacucc      540

cucuccucca cccucacccu cuccaaggcc gacuacgaga agcacaaggu cuacgccugc      600

gaggucaccc accagggccu cuccuccccc gucaccaagu ccuucaaccg cggcgagugc      660

ugaggacuag uuauaagacu gacuagcccg augggccucc caacgggccc uccuccccuc      720

cuugcaccga gauuaauaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa      780

aaaaaaaaaa aaaaaaaaaa augcaucccc cccccccccc cccccccccc cccccccaaa      840

ggcucuuuuc agagccacca gaauu                                            865


<210>  973
<211>  865
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Ipilimumab LC without signale peptide

<400>  973
gggagaaagc uuaccgagau cgugcugacc cagagccccg gcacacucuc ccuuucuccu       60

ggggaaagag ccacucuguc augcagggcu agucaaagcg ucggauccuc uuacuuggca      120

ugguaucagc agaagccagg ucaggccccg cgguuacuga uuuacggcgc guucucgcgc      180

gcuacgggga uacccgaccg auuuucagga agcggcagug guaccgauuu cacacuaacu      240

aucucccguc ucgagccuga agacuuugcc guuuauuacu gucaacagua ugggucuagc      300

ccauggaccu ucggacaggg cacaaaagug gagauuaaga gaaccguagc agcccccucc      360

guguuuaucu ucccuccauc agaugaacag cugaaaagug gcacugcuag cgucgugugc      420

cuucugaaca auuuuuaccc cagggaggca aagguucaau ggaaagugga caacgccuug      480

cagucuggaa auucccagga gucagucaca gaacaggaua gcaaggacag uaccuauucu      540

cucuccagca cgcugacucu gucgaaggcu gauuacgaga aacacaaggu guacgccugu      600

gaaguaaccc aucaagggcu cucuuccccu guuacaaaau cauucaaccg gggugagugc      660

ugaggacuag uuauaagacu gacuagcccg augggccucc caacgggccc uccuccccuc      720

cuugcaccga gauuaauaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa      780

aaaaaaaaaa aaaaaaaaaa augcaucccc cccccccccc cccccccccc cccccccaaa      840

ggcucuuuuc agagccacca gaauu                                            865


<210>  974
<211>  865
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Ipilimumab LC without signale peptide

<400>  974
gggagaaagc uuaccgagau cgugcugacc cagagccccg gcacccugag ccugagcccc       60

ggcgagagag ccacccugag cugcagagcc agccagagcg ugggcagcag cuaccuggcc      120

ugguaccagc agaagcccgg ccaggccccc agacugcuga ucuacggcgc cuucagcaga      180

gccaccggca uccccgacag auucagcggc agcggcagcg gcaccgacuu cacccugacc      240

aucagcagac uggagcccga ggacuucgcc guguacuacu gccagcagua cggcagcagc      300

cccuggaccu ucggccaggg caccaaggug gagaucaaga gaaccguggc cgcccccagc      360

guguucaucu ucccccccag cgacgagcag cugaagagcg gcaccgccag cguggugugc      420

cugcugaaca acuucuaccc cagagaggcc aaggugcagu ggaaggugga caacgcccug      480

cagagcggca acagccagga gagcgugacc gagcaggaca gcaaggacag caccuacagc      540

cugagcagca cccugacccu gagcaaggcc gacuacgaga agcacaaggu guacgccugc      600

gaggugaccc accagggccu gagcagcccc gugaccaaga gcuucaacag aggcgagugc      660

ugaggacuag uuauaagacu gacuagcccg augggccucc caacgggccc uccuccccuc      720

cuugcaccga gauuaauaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa      780

aaaaaaaaaa aaaaaaaaaa augcaucccc cccccccccc cccccccccc cccccccaaa      840

ggcucuuuuc agagccacca gaauu                                            865


<210>  975
<211>  865
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Ipilimumab LC without signale peptide

<400>  975
gggagaaagc uuaccgagau cgugcugacc cagagccccg gcacacucag ccugucuccu       60

ggggaaagag ccacgcuuag cugccgggcu ucccaaucug ucggaagcuc cuaccuggcc      120

ugguaucagc agaagccggg ccaggcgccc cgccuccuga uuuacggggc uuucucuaga      180

gccaccggaa ucccugaccg guuuagcggc uccgggagcg gaacagauuu cacccuuaca      240

auuucucgcc uggagcccga agacuuugcc guuuauuacu gucaacagua uggcuccagc      300

ccuuggaccu ucggccaggg gacaaaagug gagaucaaga gaaccguggc ugcccccucu      360

gucuuuauuu ucccuccguc cgaugaacag cucaaaagcg gaacggcuuc ugugguuugc      420

cugcugaaca auuuuuaccc ccgggaggcc aaggugcaau ggaaagucga caacgcgcuc      480

caguccggca auagccagga guccgugacc gaacaggauu cuaaggacag cacauauucc      540

cugagcucua cccuuacacu guccaaggcc gauuacgaga aacacaaggu uuacgcuugu      600

gaagugaccc aucaagggcu cagcucuccu gucacgaaau ccuucaaccg cggagagugc      660

ugaggacuag uuauaagacu gacuagcccg augggccucc caacgggccc uccuccccuc      720

cuugcaccga gauuaauaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa      780

aaaaaaaaaa aaaaaaaaaa augcaucccc cccccccccc cccccccccc cccccccaaa      840

ggcucuuuuc agagccacca gaauu                                            865


<210>  976
<211>  865
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Ipilimumab LC without signale peptide

<400>  976
gggagaaagc uuaccgaaau aguacuaaca caaucaccag gaacccucuc acuaucucca       60

ggagaaagag caacacuaag cugcagagcc ucacaaucag ucggaucauc auaccuagca      120

ugguaccaac aaaaaccagg acaagccccc agauuacuaa ucuacggagc auucucacga      180

gcaacaggaa ucccagacag auucucaggu uccggaucag gaacagacuu cacacuaaca      240

auauccagau uagaaccaga agacuucgca guauacuacu gccaacaaua cggaucauca      300

ccauggacau uuggacaagg aaccaaagua gaaaucaaaa gaacaguagc agccccauca      360

guauuuauau ucccaccauc agacgaacaa cuaaaaucag gcaccgcauc aguaguaugu      420

cuauuaaaca acuucuaccc aagagaagca aaaguacaau ggaaaguaga caacgcacua      480

caaucaggaa acucccaaga aucagucaca gaacaagacu caaaagacuc aacauacuca      540

cuaucaucaa cacuaaccuu aucaaaagca gacuacgaaa aacacaaagu auacgcaugc      600

gaaguaacac accaaggauu aucaucccca guaacaaaau cauucaacag aggagaaugc      660

ugaggacuag uuauaagacu gacuagcccg augggccucc caacgggccc uccuccccuc      720

cuugcaccga gauuaauaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa      780

aaaaaaaaaa aaaaaaaaaa augcaucccc cccccccccc cccccccccc cccccccaaa      840

ggcucuuuuc agagccacca gaauu                                            865


<210>  977
<211>  865
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Ipilimumab LC without signale peptide

<400>  977
gggagaaagc uuaccgagau cgugcugacc cagagccccg gcacucucuc ccugagucca       60

ggggaaaggg ccaccuugag cugccgggca ucccaaagug ucgguagcuc cuaccuggcc      120

ugguaucagc agaagccggg ccaggcgccc cgccuccuga uuuacggggc cuucagcagg      180

gcaacgggca ucccagaccg guuuuccggu agugggagcg gcacugauuu caccuugacc      240

auuucccgcc uggagcccga agacuuugcc guguauuacu gucaacagua uggcagcagu      300

ccauggacuu ucgggcaggg uaccaaagua gagaucaaga ggacgguggc agcccccucc      360

gucuuuauuu ucccaccgag cgaugaacag cucaaauccg gcacugcgag uguggugugc      420

cugcugaaca auuuuuaccc ccgggaggcc aagguccaau ggaaagugga caacgcacuc      480

cagagcggca auucccagga gagcguaacc gaacaggaua guaaggacuc cacuuauagc      540

cugaguucca ccuugacccu gagcaaggcc gauuacgaga aacacaaggu guacgccugu      600

gaagucacgc aucaagggcu cagcucccca gugacuaaaa guuucaaccg cggugagugc      660

ugaggacuag uuauaagacu gacuagcccg augggccucc caacgggccc uccuccccuc      720

cuugcaccga gauuaauaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa      780

aaaaaaaaaa aaaaaaaaaa augcaucccc cccccccccc cccccccccc cccccccaaa      840

ggcucuuuuc agagccacca gaauu                                            865


<210>  978
<211>  865
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Ipilimumab LC without signale peptide

<400>  978
gggagaaagc uuaccgaaau cguccuaacc caaucccccg gcacacuauc ucucucccca       60

ggcgaacgcg caacacuauc cugccgcgcc ucacaaucag ucggcuccuc cuaccuagcc      120

ugguaccaac aaaaacccgg ccaagcaccc cgacuccuca ucuacggcgc cuucucccgc      180

gccacaggca ucccagaccg cuucuccggc uccggcuccg gcacagacuu cacacucacc      240

aucucacgcc ucgaacccga agacuucgcc gucuacuacu gccaacaaua cggaucaucc      300

cccuggaccu ucggacaagg caccaaaguc gaaaucaaac gcaccgucgc cgcccccucc      360

gucuucaucu ucccacccuc agacgaacaa cuaaaauccg gcaccgccuc aguagucugc      420

cuacuaaaca acuucuaccc ccgcgaagcc aaaguccaau ggaaagucga caacgcccuc      480

caauccggca acucacaaga aucagucacc gaacaagacu caaaagacuc caccuacucc      540

cuauccucca cccucacccu aucaaaagcc gacuacgaaa aacacaaagu auacgcgugc      600

gaaguaaccc accagggccu auccucaccc gucacaaaau ccuucaaccg cggcgaaugc      660

ugaggacuag uuauaagacu gacuagcccg augggccucc caacgggccc uccuccccuc      720

cuugcaccga gauuaauaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa      780

aaaaaaaaaa aaaaaaaaaa augcaucccc cccccccccc cccccccccc cccccccaaa      840

ggcucuuuuc agagccacca gaauu                                            865


<210>  979
<211>  865
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Ipilimumab LC without signale peptide

<400>  979
gggagaaagc uuaccgaaau cguacuaacc caaucacccg gcacccucuc ccucuccccc       60

ggcgaacgag ccacccuauc augccgcgcc ucccaauccg uaggcuccuc cuaccuagcc      120

ugguaccaac aaaaaccagg ccaagcaccc cgacuacuca ucuacggagc cuucucccgc      180

gccaccggca uccccgaccg cuucuccggc uccggcuccg gcaccgacuu cacccucacc      240

aucucccgcc ucgaacccga agacuucgcc gucuacuacu gccaacaaua cggaucaucc      300

cccuggaccu ucggccaagg caccaaaguc gaaaucaaac gcaccgucgc cgcccccucc      360

gucuucauau ucccacccuc cgacgaacaa cuaaaaucag gaaccgccuc cgucgucugc      420

cuacuaaaca acuucuaccc ccgcgaagcc aaaguacaau ggaaagucga caacgcccuc      480

caauccggca acucccaaga auccguaacc gaacaagacu ccaaagacuc aaccuauucc      540

cucuccucca cacucacacu auccaaagcc gacuacgaaa aacacaaagu cuacgccugc      600

gaaguaaccc accaaggccu cucaucaccc gucaccaaau ccuucaaccg cggcgaaugc      660

uaaggacuag uuauaagacu gacuagcccg augggccucc caacgggccc uccuccccuc      720

cuugcaccga gauuaauaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa      780

aaaaaaaaaa aaaaaaaaaa augcaucccc cccccccccc cccccccccc cccccccaaa      840

ggcucuuuuc agagccacca gaauu                                            865


<210>  980
<211>  865
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Ipilimumab LC without signale peptide

<400>  980
gggagaaagc uuaccgaaau cguccucacc caaucccccg gcacccuauc acucucaccc       60

ggcgaacgcg caacccucuc cugccgagcc ucccaauccg ucggcuccuc auaccucgcc      120

ugguaccaac aaaaacccgg ccaagcaccc cgucuccuca ucuacggcgc cuucucacgc      180

gccaccggca uccccgaccg cuucuccggc ucuggcucag gcaccgacuu cacccucacc      240

aucucccgcc ucgaacccga agacuucgcc gucuacuacu gccaacaaua cggaucaucc      300

cccuggaccu ucggccaagg cacaaaaguc gaaaucaaac gcaccgucgc cgccccaucc      360

gucuucaucu ucccacccuc cgacgaacaa cucaaauccg gcaccgccuc cgucgucugc      420

cuccucaaca acuucuaccc ccgcgaagcc aaaguccaau ggaaagucga caacgcccuc      480

caauccggca acucccaaga auccgucacc gaacaagacu ccaaagacuc caccuacuca      540

cucuccucca cccuuacccu cuccaaagcc gacuacgaaa aacacaaagu cuacgccugc      600

gaagucaccc accaaggccu cuccuccccc gucaccaaau ccuucaaccg cggcgaaugc      660

uaaggacuag uuauaagacu gacuagcccg augggccucc caacgggccc uccuccccuc      720

cuugcaccga gauuaauaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa      780

aaaaaaaaaa aaaaaaaaaa augcaucccc cccccccccc cccccccccc cccccccaaa      840

ggcucuuuuc agagccacca gaauu                                            865


<210>  981
<211>  865
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Ipilimumab LC without signale peptide

<400>  981
gggagaaagc uuaccgaaau aguacuaaca caaucaccag gaacacuauc acucucaccu       60

ggagaaagag caacauuauc cugcagagca ucacaaucug uaggaucuuc auaccuagca      120

ugguaccaac aaaaaccagg acaagcacca agauuacuaa uauauggagc auuuuccaga      180

gcaacaggca uaccagacag auucucagga ucaggaucag gaaccgacuu cacacuaaca      240

auaucaagac uagaaccaga agacuucgca guauacuacu gccaacaaua cggaucauca      300

ccauggacau ucggacaagg aacaaaagua gaaauaaaaa gaacagucgc agcaccauca      360

guauucauau ucccaccauc agacgaacaa uuaaaauccg gaacagcauc aguaguaugc      420

cuacuaaaua acuucuaccc aagagaagca aaaguacaau ggaaaguaga caacgcauua      480

caaucaggaa acucccaaga aucaguaaca gaacaagacu cuaaagacuc aacauacucc      540

cuaucaucaa cacuaacacu aucaaaagca gacuaugaaa aacacaaagu auacgcaugc      600

gaagucacac aucaaggacu aucaucacca guaacaaaau cauuuaacag aggagaaugc      660

uaaggacuag uuauaagacu gacuagcccg augggccucc caacgggccc uccuccccuc      720

cuugcaccga gauuaauaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa      780

aaaaaaaaaa aaaaaaaaaa augcaucccc cccccccccc cccccccccc cccccccaaa      840

ggcucuuuuc agagccacca gaauu                                            865


<210>  982
<211>  865
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Ipilimumab LC without signale peptide

<400>  982
gggagaaagc uuaccgaaau aguacuaaca caaucaccag gaacauuauc acuaucccca       60

ggagaaagag caacauuauc augcagagca ucacaaucag uaggaucauc auaccuagcc      120

ugguaccaac aaaaaccagg acaagcccca agauuacuaa uauacggagc auucucaaga      180

gcaacaggaa uaccagacag auucucaggu ucuggcucag gcacagacuu cacacucaca      240

auaucaagac uagaaccaga agacuucgcc guauacuacu gccaacaaua cggauccuca      300

ccauggacau ucggacaagg aacaaaagua gaaauaaaac gaacaguagc agcaccauca      360

guauucauau ucccaccauc agacgaacaa uuaaaaucag gaacagcauc aguaguaugc      420

cuauuaaaca acuucuaccc acgagaagcc aaaguccaau ggaaaguaga uaacgcauua      480

caaucaggua acucacaaga aucaguaaca gaacaagacu ccaaagacuc aacauacagc      540

cuaucaucaa cacuaacauu aucaaaagca gacuaugaaa aacacaaagu auacgcaugc      600

gagguaacac accaaggacu aucaucacca guaacaaaau cauucaauag aggagaaugc      660

uaaggacuag uuauaagacu gacuagcccg augggccucc caacgggccc uccuccccuc      720

cuugcaccga gauuaauaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa      780

aaaaaaaaaa aaaaaaaaaa augcaucccc cccccccccc cccccccccc cccccccaaa      840

ggcucuuuuc agagccacca gaauu                                            865


<210>  983
<211>  865
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Ipilimumab backbone Rituximab LC without signale peptide

<400>  983
gggagaaagc uuaccgagau cgugcugacc cagagccccg gcacccucuc ccugagcccg       60

ggggagcgcg ccacgcuguc cugccgggcc agccaguccg ucggcagcuc cuaccucgcg      120

ugguaccagc agaagcccgg gcaggcgccc cgccugcuga ucuacggcgc cuucagccgg      180

gccaccggga uccccgaccg cuucuccggc agcggcuccg ggaccgacuu cacccucacg      240

aucagccggc uggagccgga ggacuucgcc guguacuacu gccagcagua cggcuccagc      300

cccuggaccu ucgggcaggg caccaaggug gagaucaagc gcaccguggc ggcccccagc      360

guguucaucu ucccgcccag cgacgagcag cugaagagcg ggaccgccuc ggucgugugc      420

cuccugaaca acuucuaccc ccgggaggcc aaggugcagu ggaaggucga caacgcgcug      480

cagagcggca acagccagga gagcgugacg gagcaggaca gcaaggacag caccuacucg      540

cucagcagca cccugacccu gagcaaggcc gacuacgaga agcacaaggu guacgccugc      600

gaggucacgc accaggggcu cagcucgccc gugaccaaga gcuucaaccg cggggagugc      660

ugaggacuag uuauaagacu gacuagcccg augggccucc caacgggccc uccuccccuc      720

cuugcaccga gauuaauaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa      780

aaaaaaaaaa aaaaaaaaaa augcaucccc cccccccccc cccccccccc cccccccaaa      840

ggcucuuuuc agagccacca gaauu                                            865


<210>  984
<211>  865
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Ipilimumab backbone Rituximab LC without signale peptide

<400>  984
gggagaaagc uuaccgagau cgugcugacc cagagccccg gcacacucuc ccuuucuccu       60

ggggaaagag ccacucuguc augcagggcu agucaaagcg ucggauccuc uuacuuggca      120

ugguaucagc agaagccagg ucaggccccg cgguuacuga uuuacggcgc guucucgcgc      180

gcuacgggga uacccgaccg auuuucagga agcggcagug guaccgauuu cacacuaacu      240

aucucccguc ucgagccuga agacuuugcc guuuauuacu gucaacagua ugggucuagc      300

ccauggaccu ucggacaggg cacaaaagug gagauuaaga gaaccguggc ggcccccagc      360

guguucaucu ucccgcccag cgacgagcag cugaagagcg ggaccgccuc ggucgugugc      420

cuccugaaca acuucuaccc ccgggaggcc aaggugcagu ggaaggucga caacgcgcug      480

cagagcggca acagccagga gagcgugacg gagcaggaca gcaaggacag caccuacucg      540

cucagcagca cccugacccu gagcaaggcc gacuacgaga agcacaaggu guacgccugc      600

gaggucacgc accaggggcu cagcucgccc gugaccaaga gcuucaaccg cggugagugc      660

ugaggacuag uuauaagacu gacuagcccg augggccucc caacgggccc uccuccccuc      720

cuugcaccga gauuaauaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa      780

aaaaaaaaaa aaaaaaaaaa augcaucccc cccccccccc cccccccccc cccccccaaa      840

ggcucuuuuc agagccacca gaauu                                            865


<210>  985
<211>  865
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Ipilimumab backbone Rituximab LC without signale peptide

<400>  985
gggagaaagc uuaccgagau cgugcugacc cagagccccg gcacccugag ccugagcccc       60

ggcgagagag ccacccugag cugcagagcc agccagagcg ugggcagcag cuaccuggcc      120

ugguaccagc agaagcccgg ccaggccccc agacugcuga ucuacggcgc cuucagcaga      180

gccaccggca uccccgacag auucagcggc agcggcagcg gcaccgacuu cacccugacc      240

aucagcagac uggagcccga ggacuucgcc guguacuacu gccagcagua cggcagcagc      300

cccuggaccu ucggccaggg caccaaggug gagaucaaga gaaccguggc ggcccccagc      360

guguucaucu ucccgcccag cgacgagcag cugaagagcg ggaccgccuc ggucgugugc      420

cuccugaaca acuucuaccc ccgggaggcc aaggugcagu ggaaggucga caacgcgcug      480

cagagcggca acagccagga gagcgugacg gagcaggaca gcaaggacag caccuacucg      540

cucagcagca cccugacccu gagcaaggcc gacuacgaga agcacaaggu guacgccugc      600

gaggucacgc accaggggcu cagcucgccc gugaccaaga gcuucaaccg cggcgagugc      660

ugaggacuag uuauaagacu gacuagcccg augggccucc caacgggccc uccuccccuc      720

cuugcaccga gauuaauaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa      780

aaaaaaaaaa aaaaaaaaaa augcaucccc cccccccccc cccccccccc cccccccaaa      840

ggcucuuuuc agagccacca gaauu                                            865


<210>  986
<211>  3008
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Ipilimumab opt1 IRES construct

<400>  986
gggagaaagc uuaccaugga gcugggccuc agcuggaucu uccugcuggc cauccucaag       60

ggggugcagu gccaggugca gcuggucgag agcggcgggg gcguggugca gcccgggcgc      120

ucccuccggc ugagcugcgc cgccuccggc uucaccuuca gcuccuacac caugcacugg      180

guccgccagg cgccggggaa gggccuggag ugggugacgu ucaucagcua cgacggcaac      240

aacaaguacu acgccgacuc cgugaagggg cgguucacca ucagccgcga caacuccaag      300

aacacccucu accugcagau gaacagccug cgggccgagg acaccgccau cuacuacugc      360

gcccgcacgg gcuggcucgg gcccuucgac uacuggggcc aggggacccu ggucaccgug      420

uccagcgcgu ccaccaaggg ccccagcgug uucccccugg ccccguccag caaguccacg      480

agcggcggga ccgccgcccu cggcugccug gucaaggacu acuuccccga gcccgugacc      540

guguccugga acagcggggc gcugaccagc ggcguccaca cguuccccgc cgugcuccag      600

uccagcggcc uguacucccu gagcuccgug gucaccgugc cgagcuccag ccucgggacc      660

cagaccuaca ucugcaacgu gaaccacaag cccuccaaca cgaaggucga caagcgggug      720

gagcccaaga gcugcgacaa gacccacacg ugcccgcccu gccccgcccc cgagcugcug      780

ggcgggcccu ccguguuccu cuucccgccc aagcccaagg acacccugau gaucagccgc      840

acccccgagg ugaccugcgu cguggucgac gugucccacg aggacccgga ggucaaguuc      900

aacugguacg uggacggcgu ggagguccac aacgccaaga ccaagccccg ggaggagcag      960

uacaacagca ccuaccgcgu gguguccguc cugacggugc uccaccagga cuggcugaac     1020

gggaaggagu acaagugcaa ggugagcaac aaggcccugc ccgcgcccau cgagaagacc     1080

aucuccaagg ccaagggcca gccgcgggag ccccaggucu acacccuccc gcccagccgc     1140

gacgagcuga ccaagaacca ggugucccug acgugccucg ugaagggcuu cuaccccagc     1200

gacaucgccg ucgaguggga gagcaacggg cagcccgaga acaacuacaa gaccacgccc     1260

ccggugcugg acuccgacgg cagcuucuuc cuguacucca agcucaccgu ggacaagagc     1320

cgguggcagc aggggaacgu cuucuccugc agcgugaugc acgaggcccu gcacaaccac     1380

uacacccaga agucccugag ccucuccccc ggcaagugac caugcauuug aaagccgggg     1440

gugggagauc cggauugcca gucugcucga uaucgcaggc uggguccgug acuacccacu     1500

cccccuuuaa uuccgccccu cucccucccc ccccccuaac guuacuggcc gaagccgcuu     1560

ggaauaaggc cggugugcgu uugucuauau guuauuuucc accauauugc cgucuuuugg     1620

caaugugagg gcccggaaac cuggcccugu cuucuugacg agcauuccua ggggucuuuc     1680

cccucucgcc aaaggaaugc aaggucuguu gaaugucgug aaggaagcag uuccucugga     1740

agcuucuuga agacaaacaa cgucuguagc gacccuuugc aggcagcgga accccccacc     1800

uggcgacagg ugccucugcg gccaaaagcc acguguauaa gauacaccug caaaggcggc     1860

acaaccccag ugccacguug ugaguuggau aguuguggaa agagucaaau ggcucuccuc     1920

aagcguauuc aacaaggggc ugaaggaugc ccagaaggua ccccauugua ugggaucuga     1980

ucuggggccu cggugcacau gcuuuacgug uguuuagucg agguuaaaaa acgucuaggc     2040

cccccgaacc acggggacgu gguuuuccuu ugaaaaacac gaugauaaua gaucuaccau     2100

ggagaccccc gcccagcugc ucuuccugcu gcuccugugg cugccggaca ccacgggcga     2160

gaucgugcug acccagagcc ccggcacccu cucccugagc ccgggggagc gcgccacgcu     2220

guccugccgg gccagccagu ccgucggcag cuccuaccuc gcgugguacc agcagaagcc     2280

cgggcaggcg ccccgccugc ugaucuacgg cgccuucagc cgggccaccg ggauccccga     2340

ccgcuucucc ggcagcggcu ccgggaccga cuucacccuc acgaucagcc ggcuggagcc     2400

ggaggacuuc gccguguacu acugccagca guacggcucc agccccugga ccuucgggca     2460

gggcaccaag guggagauca agcgcaccgu cgccgccccc uccguguuca ucuucccgcc     2520

cagcgacgag cagcugaagu ccgggacggc cagcgugguc ugccuccuga acaacuucua     2580

cccccgggag gccaaggugc aguggaaggu ggacaacgcg cugcaguccg gcaacagcca     2640

ggagagcguc accgagcagg acuccaagga cagcaccuac ucccucagcu ccacccugac     2700

gcugagcaag gccgacuacg agaagcacaa gguguacgcc ugcgagguga cccaccaggg     2760

ccucuccagc cccgucacca aguccuucaa ccgcggggag ugcugaggac uaguuauaag     2820

acugacuagc ccgaugggcc ucccaacggg cccuccuccc cuccuugcac cgagauuaau     2880

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa     2940

aaaaugcauc cccccccccc cccccccccc cccccccccc aaaggcucuu uucagagcca     3000

ccagaauu                                                              3008


<210>  987
<211>  3008
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Ipilimumab opt3 IRES construct

<400>  987
gggagaaagc uuaccaugga gcugggccuc agcuggaucu uccuucuggc cauuuugaag       60

ggggugcagu gccaagucca guuaguugaa uccggaggug gcgugguaca gcccgggaga      120

ucucugaggc uaucaugugc ugcaagugga uuuaccuuca gcuccuacac aaugcacugg      180

gugcggcagg ccccuggcaa aggucucgag ugggucacuu uuauaucuua ugacgggaac      240

aauaaguacu augcggauuc ggugaaagga cgcuucacga ucucacgaga caacagcaag      300

aauacccugu accuucaaau gaacagucug cgugcugaag auacagccau uuauuacugc      360

gcaagaacug gcugguuggg cccauuugac uauugggggc agggaacccu cguuacagug      420

uccucugcca gcaccaaagg uccguccguc uucccccugg cuccuucaag uaagagcacu      480

ucuggcggga cagcagcccu gggaugucuc gugaaggauu acuuuccaga gcccguaacc      540

guuuccugga acucaggcgc uuuaacgagc ggugugcaua cuuucccugc cguccugcag      600

aguucugggc uuuacuccuu gagcucggug gugaccgucc caucuuccuc acugggaaca      660

cagacuuaua ucugcaaugu uaaucacaaa cccaguaaca ccaaggugga caaaagggua      720

gaaccuaaga gcugugauaa aacacauacc ugcccaccgu gucccgcgcc ugagcuacuc      780

ggcggcccau ccguguuucu guuucccccu aagccaaagg acacgcuuau gauuucucgg      840

acucccgagg ucacaugcgu gguuguggau gucagccacg aagacccgga ggugaaauuu      900

aauugguacg uagauggggu ugaagugcau aacgcaaaga ccaaaccucg cgaggagcaa      960

uauaauucaa cuuacagagu cgugaguguc cugacagugu ugcaccagga cuggcucaac     1020

ggaaaggaau auaaauguaa gguuuccaau aaagcccugc ccgcuccaau cgagaagacc     1080

auaagcaagg ccaaagguca gccuagggaa ccccaggugu acacguuacc acccucucgg     1140

gaugagcuga ccaagaacca aguaucacuc acaugccuug ucaaaggcuu cuauccuagu     1200

gacaucgcag uggaauggga gagcaauggg cagccagaga acaacuacaa gacuaccccg     1260

cccguucugg acuccgaugg aucuuucuuc uuguacucga aacuaacagu ggacaagagc     1320

cgcuggcagc aaggcaaugu cuucuccugu ucagugaugc acgaagcucu gcauaaccac     1380

uauacucaga agagucucuc ucugagcccu gguaaaugac caugcauuug aaagccgggg     1440

gugggagauc cggauugcca gucugcucga uaucgcaggc uggguccgug acuacccacu     1500

cccccuuuaa uuccgccccu cucccucccc ccccccuaac guuacuggcc gaagccgcuu     1560

ggaauaaggc cggugugcgu uugucuauau guuauuuucc accauauugc cgucuuuugg     1620

caaugugagg gcccggaaac cuggcccugu cuucuugacg agcauuccua ggggucuuuc     1680

cccucucgcc aaaggaaugc aaggucuguu gaaugucgug aaggaagcag uuccucugga     1740

agcuucuuga agacaaacaa cgucuguagc gacccuuugc aggcagcgga accccccacc     1800

uggcgacagg ugccucugcg gccaaaagcc acguguauaa gauacaccug caaaggcggc     1860

acaaccccag ugccacguug ugaguuggau aguuguggaa agagucaaau ggcucuccuc     1920

aagcguauuc aacaaggggc ugaaggaugc ccagaaggua ccccauugua ugggaucuga     1980

ucuggggccu cggugcacau gcuuuacgug uguuuagucg agguuaaaaa acgucuaggc     2040

cccccgaacc acggggacgu gguuuuccuu ugaaaaacac gaugauaaua gaucuaccau     2100

ggagaccccc gcccagcuuc ucuuccuucu guuguuaugg cugccugaca caacuggcga     2160

aaucgugcua acgcaaagcc cagggacccu cucccugucu ccgggagaga gagcuacacu     2220

uucaugcagg gcaagucaga gcgucgguuc cucuuaccug gccugguauc agcagaagcc     2280

cggccaagcg ccucgguugc ucauuuacgg ggcuuuuucg cgcgccacug gaauaccaga     2340

ucgauucuca ggcagcggua gugggaccga cuuuacacug accaucuccc gucuggaacc     2400

cgaggauuuc gcaguuuauu acugucagca guauggaucu agcccuugga cuuuuggcca     2460

gggcacaaaa guggaaauua agagaaccgu agccgcucca uccguguuca ucuuuccccc     2520

uucagacgag caacucaaaa gugggacggc aagcgucgug ugcuuacuga acaauuucua     2580

cccaagggag gccaagguuc aguggaaagu ggauaacgcu cugcagucug gaaauuccca     2640

ggaaucaguc acugagcaag acagcaagga uaguaccuau ucuuugucca gcacacugac     2700

ucuaucgaag gccgacuacg aaaaacacaa gguguacgcg ugugagguaa cccaucaggg     2760

ucucucuucc ccgguuacaa aaucauuuaa ccggggcgag ugcugaggac uaguuauaag     2820

acugacuagc ccgaugggcc ucccaacggg cccuccuccc cuccuugcac cgagauuaau     2880

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa     2940

aaaaugcauc cccccccccc cccccccccc cccccccccc aaaggcucuu uucagagcca     3000

ccagaauu                                                              3008


<210>  988
<211>  3008
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Ipilimumab opt4 IRES construct

<400>  988
gggagaaagc uuaccaugga gcugggccug agcuggaucu uccugcuggc cauccugaag       60

ggcgugcagu gccaggugca gcugguggag agcggcggcg gcguggugca gcccggcaga      120

agccugagac ugagcugcgc cgccagcggc uucaccuuca gcagcuacac caugcacugg      180

gugagacagg cccccggcaa gggccuggag ugggugaccu ucaucagcua cgacggcaac      240

aacaaguacu acgccgacag cgugaagggc agauucacca ucagcagaga caacagcaag      300

aacacccugu accugcagau gaacagccug agagccgagg acaccgccau cuacuacugc      360

gccagaaccg gcuggcuggg ccccuucgac uacuggggcc agggcacccu ggugaccgug      420

agcagcgcca gcaccaaggg ccccagcgug uucccccugg cccccagcag caagagcacc      480

agcggcggca ccgccgcccu gggcugccug gugaaggacu acuuccccga gcccgugacc      540

gugagcugga acagcggcgc ccugaccagc ggcgugcaca ccuuccccgc cgugcugcag      600

agcagcggcc uguacagccu gagcagcgug gugaccgugc ccagcagcag ccugggcacc      660

cagaccuaca ucugcaacgu gaaccacaag cccagcaaca ccaaggugga caagagagug      720

gagcccaaga gcugcgacaa gacccacacc ugcccccccu gccccgcccc cgagcugcug      780

ggcggcccca gcguguuccu guuccccccc aagcccaagg acacccugau gaucagcaga      840

acccccgagg ugaccugcgu ggugguggac gugagccacg aggaccccga ggugaaguuc      900

aacugguacg uggacggcgu ggaggugcac aacgccaaga ccaagcccag agaggagcag      960

uacaacagca ccuacagagu ggugagcgug cugaccgugc ugcaccagga cuggcugaac     1020

ggcaaggagu acaagugcaa ggugagcaac aaggcccugc ccgcccccau cgagaagacc     1080

aucagcaagg ccaagggcca gcccagagag ccccaggugu acacccugcc ccccagcaga     1140

gacgagcuga ccaagaacca ggugagccug accugccugg ugaagggcuu cuaccccagc     1200

gacaucgccg uggaguggga gagcaacggc cagcccgaga acaacuacaa gaccaccccc     1260

cccgugcugg acagcgacgg cagcuucuuc cuguacagca agcugaccgu ggacaagagc     1320

agauggcagc agggcaacgu guucagcugc agcgugaugc acgaggcccu gcacaaccac     1380

uacacccaga agagccugag ccugagcccc ggcaagugac caugcauuug aaagccgggg     1440

gugggagauc cggauugcca gucugcucga uaucgcaggc uggguccgug acuacccacu     1500

cccccuuuaa uuccgccccu cucccucccc ccccccuaac guuacuggcc gaagccgcuu     1560

ggaauaaggc cggugugcgu uugucuauau guuauuuucc accauauugc cgucuuuugg     1620

caaugugagg gcccggaaac cuggcccugu cuucuugacg agcauuccua ggggucuuuc     1680

cccucucgcc aaaggaaugc aaggucuguu gaaugucgug aaggaagcag uuccucugga     1740

agcuucuuga agacaaacaa cgucuguagc gacccuuugc aggcagcgga accccccacc     1800

uggcgacagg ugccucugcg gccaaaagcc acguguauaa gauacaccug caaaggcggc     1860

acaaccccag ugccacguug ugaguuggau aguuguggaa agagucaaau ggcucuccuc     1920

aagcguauuc aacaaggggc ugaaggaugc ccagaaggua ccccauugua ugggaucuga     1980

ucuggggccu cggugcacau gcuuuacgug uguuuagucg agguuaaaaa acgucuaggc     2040

cccccgaacc acggggacgu gguuuuccuu ugaaaaacac gaugauaaua gaucuaccau     2100

ggagaccccc gcccagcugc uguuccugcu gcugcugugg cugcccgaca ccaccggcga     2160

gaucgugcug acccagagcc ccggcacccu gagccugagc cccggcgaga gagccacccu     2220

gagcugcaga gccagccaga gcgugggcag cagcuaccug gccugguacc agcagaagcc     2280

cggccaggcc cccagacugc ugaucuacgg cgccuucagc agagccaccg gcauccccga     2340

cagauucagc ggcagcggca gcggcaccga cuucacccug accaucagca gacuggagcc     2400

cgaggacuuc gccguguacu acugccagca guacggcagc agccccugga ccuucggcca     2460

gggcaccaag guggagauca agagaaccgu ggccgccccc agcguguuca ucuucccccc     2520

cagcgacgag cagcugaaga gcggcaccgc cagcguggug ugccugcuga acaacuucua     2580

ccccagagag gccaaggugc aguggaaggu ggacaacgcc cugcagagcg gcaacagcca     2640

ggagagcgug accgagcagg acagcaagga cagcaccuac agccugagca gcacccugac     2700

ccugagcaag gccgacuacg agaagcacaa gguguacgcc ugcgagguga cccaccaggg     2760

ccugagcagc cccgugacca agagcuucaa cagaggcgag ugcugaggac uaguuauaag     2820

acugacuagc ccgaugggcc ucccaacggg cccuccuccc cuccuugcac cgagauuaau     2880

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa     2940

aaaaugcauc cccccccccc cccccccccc cccccccccc aaaggcucuu uucagagcca     3000

ccagaauu                                                              3008


<210>  989
<211>  2392
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Ipilimumab opt1 F2A construct

<400>  989
gggagaaagc uuaccaugga gcugggccuc agcuggaucu uccugcuggc cauccucaag       60

ggggugcagu gccaggugca gcuggucgag agcggcgggg gcguggugca gcccgggcgc      120

ucccuccggc ugagcugcgc cgccuccggc uucaccuuca gcuccuacac caugcacugg      180

guccgccagg cgccggggaa gggccuggag ugggugacgu ucaucagcua cgacggcaac      240

aacaaguacu acgccgacuc cgugaagggg cgguucacca ucagccgcga caacuccaag      300

aacacccucu accugcagau gaacagccug cgggccgagg acaccgccau cuacuacugc      360

gcccgcacgg gcuggcucgg gcccuucgac uacuggggcc aggggacccu ggucaccgug      420

uccagcgcgu ccaccaaggg ccccagcgug uucccccugg ccccguccag caaguccacg      480

agcggcggga ccgccgcccu cggcugccug gucaaggacu acuuccccga gcccgugacc      540

guguccugga acagcggggc gcugaccagc ggcguccaca cguuccccgc cgugcuccag      600

uccagcggcc uguacucccu gagcuccgug gucaccgugc cgagcuccag ccucgggacc      660

cagaccuaca ucugcaacgu gaaccacaag cccuccaaca cgaaggucga caagcgggug      720

gagcccaaga gcugcgacaa gacccacacg ugcccgcccu gccccgcccc cgagcugcug      780

ggcgggcccu ccguguuccu cuucccgccc aagcccaagg acacccugau gaucagccgc      840

acccccgagg ugaccugcgu cguggucgac gugucccacg aggacccgga ggucaaguuc      900

aacugguacg uggacggcgu ggagguccac aacgccaaga ccaagccccg ggaggagcag      960

uacaacagca ccuaccgcgu gguguccguc cugacggugc uccaccagga cuggcugaac     1020

gggaaggagu acaagugcaa ggugagcaac aaggcccugc ccgcgcccau cgagaagacc     1080

aucuccaagg ccaagggcca gccgcgggag ccccaggucu acacccuccc gcccagccgc     1140

gacgagcuga ccaagaacca ggugucccug acgugccucg ugaagggcuu cuaccccagc     1200

gacaucgccg ucgaguggga gagcaacggg cagcccgaga acaacuacaa gaccacgccc     1260

ccggugcugg acuccgacgg cagcuucuuc cuguacucca agcucaccgu ggacaagagc     1320

cgguggcagc aggggaacgu cuucuccugc agcgugaugc acgaggcccu gcacaaccac     1380

uacacccaga agucccugag ccucuccccc ggcaagguga agcagacacu caauuucgac     1440

cuucugaagu uggcuggaga uguugagucu aacccaggcc ccauggagac ccccgcccag     1500

cugcucuucc ugcugcuccu guggcugccg gacaccacgg gcgagaucgu gcugacccag     1560

agccccggca cccucucccu gagcccgggg gagcgcgcca cgcuguccug ccgggccagc     1620

caguccgucg gcagcuccua ccucgcgugg uaccagcaga agcccgggca ggcgccccgc     1680

cugcugaucu acggcgccuu cagccgggcc accgggaucc ccgaccgcuu cuccggcagc     1740

ggcuccggga ccgacuucac ccucacgauc agccggcugg agccggagga cuucgccgug     1800

uacuacugcc agcaguacgg cuccagcccc uggaccuucg ggcagggcac caagguggag     1860

aucaagcgca ccgucgccgc ccccuccgug uucaucuucc cgcccagcga cgagcagcug     1920

aaguccggga cggccagcgu ggucugccuc cugaacaacu ucuacccccg ggaggccaag     1980

gugcagugga agguggacaa cgcgcugcag uccggcaaca gccaggagag cgucaccgag     2040

caggacucca aggacagcac cuacucccuc agcuccaccc ugacgcugag caaggccgac     2100

uacgagaagc acaaggugua cgccugcgag gugacccacc agggccucuc cagccccguc     2160

accaaguccu ucaaccgcgg ggagugcuga ggacuaguua uaagacugac uagcccgaug     2220

ggccucccaa cgggcccucc uccccuccuu gcaccgagau uaauaaaaaa aaaaaaaaaa     2280

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaug cauccccccc     2340

cccccccccc cccccccccc ccccaaaggc ucuuuucaga gccaccagaa uu             2392


<210>  990
<211>  2392
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Ipilimumab opt3 F2A construct

<400>  990
gggagaaagc uuaccaugga gcugggccuc agcuggaucu uccuucuggc cauuuugaag       60

ggggugcagu gccaagucca guuaguugaa uccggaggug gcgugguaca gcccgggaga      120

ucucugaggc uaucaugugc ugcaagugga uuuaccuuca gcuccuacac aaugcacugg      180

gugcggcagg ccccuggcaa aggucucgag ugggucacuu uuauaucuua ugacgggaac      240

aauaaguacu augcggauuc ggugaaagga cgcuucacga ucucacgaga caacagcaag      300

aauacccugu accuucaaau gaacagucug cgugcugaag auacagccau uuauuacugc      360

gcaagaacug gcugguuggg cccauuugac uauugggggc agggaacccu cguuacagug      420

uccucugcca gcaccaaagg uccguccguc uucccccugg cuccuucaag uaagagcacu      480

ucuggcggga cagcagcccu gggaugucuc gugaaggauu acuuuccaga gcccguaacc      540

guuuccugga acucaggcgc uuuaacgagc ggugugcaua cuuucccugc cguccugcag      600

aguucugggc uuuacuccuu gagcucggug gugaccgucc caucuuccuc acugggaaca      660

cagacuuaua ucugcaaugu uaaucacaaa cccaguaaca ccaaggugga caaaagggua      720

gaaccuaaga gcugugauaa aacacauacc ugcccaccgu gucccgcgcc ugagcuacuc      780

ggcggcccau ccguguuucu guuucccccu aagccaaagg acacgcuuau gauuucucgg      840

acucccgagg ucacaugcgu gguuguggau gucagccacg aagacccgga ggugaaauuu      900

aauugguacg uagauggggu ugaagugcau aacgcaaaga ccaaaccucg cgaggagcaa      960

uauaauucaa cuuacagagu cgugaguguc cugacagugu ugcaccagga cuggcucaac     1020

ggaaaggaau auaaauguaa gguuuccaau aaagcccugc ccgcuccaau cgagaagacc     1080

auaagcaagg ccaaagguca gccuagggaa ccccaggugu acacguuacc acccucucgg     1140

gaugagcuga ccaagaacca aguaucacuc acaugccuug ucaaaggcuu cuauccuagu     1200

gacaucgcag uggaauggga gagcaauggg cagccagaga acaacuacaa gacuaccccg     1260

cccguucugg acuccgaugg aucuuucuuc uuguacucga aacuaacagu ggacaagagc     1320

cgcuggcagc aaggcaaugu cuucuccugu ucagugaugc acgaagcucu gcauaaccac     1380

uauacucaga agagucucuc ucugagcccu gguaaaguga agcagacacu caauuucgac     1440

cuucugaagu uggcuggaga uguugagucu aacccaggcc ccauggagac ccccgcccag     1500

cuucucuucc uucuguuguu auggcugccu gacacaacug gcgaaaucgu gcuaacgcaa     1560

agcccaggga cccucucccu gucuccggga gagagagcua cacuuucaug cagggcaagu     1620

cagagcgucg guuccucuua ccuggccugg uaucagcaga agcccggcca agcgccucgg     1680

uugcucauuu acggggcuuu uucgcgcgcc acuggaauac cagaucgauu cucaggcagc     1740

gguaguggga ccgacuuuac acugaccauc ucccgucugg aacccgagga uuucgcaguu     1800

uauuacuguc agcaguaugg aucuagcccu uggacuuuug gccagggcac aaaaguggaa     1860

auuaagagaa ccguagccgc uccauccgug uucaucuuuc ccccuucaga cgagcaacuc     1920

aaaaguggga cggcaagcgu cgugugcuua cugaacaauu ucuacccaag ggaggccaag     1980

guucagugga aaguggauaa cgcucugcag ucuggaaauu cccaggaauc agucacugag     2040

caagacagca aggauaguac cuauucuuug uccagcacac ugacucuauc gaaggccgac     2100

uacgaaaaac acaaggugua cgcgugugag guaacccauc agggucucuc uuccccgguu     2160

acaaaaucau uuaaccgggg cgagugcuga ggacuaguua uaagacugac uagcccgaug     2220

ggccucccaa cgggcccucc uccccuccuu gcaccgagau uaauaaaaaa aaaaaaaaaa     2280

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaug cauccccccc     2340

cccccccccc cccccccccc ccccaaaggc ucuuuucaga gccaccagaa uu             2392


<210>  991
<211>  2392
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Ipilimumab opt4 F2A construct

<400>  991
gggagaaagc uuaccaugga gcugggccug agcuggaucu uccugcuggc cauccugaag       60

ggcgugcagu gccaggugca gcugguggag agcggcggcg gcguggugca gcccggcaga      120

agccugagac ugagcugcgc cgccagcggc uucaccuuca gcagcuacac caugcacugg      180

gugagacagg cccccggcaa gggccuggag ugggugaccu ucaucagcua cgacggcaac      240

aacaaguacu acgccgacag cgugaagggc agauucacca ucagcagaga caacagcaag      300

aacacccugu accugcagau gaacagccug agagccgagg acaccgccau cuacuacugc      360

gccagaaccg gcuggcuggg ccccuucgac uacuggggcc agggcacccu ggugaccgug      420

agcagcgcca gcaccaaggg ccccagcgug uucccccugg cccccagcag caagagcacc      480

agcggcggca ccgccgcccu gggcugccug gugaaggacu acuuccccga gcccgugacc      540

gugagcugga acagcggcgc ccugaccagc ggcgugcaca ccuuccccgc cgugcugcag      600

agcagcggcc uguacagccu gagcagcgug gugaccgugc ccagcagcag ccugggcacc      660

cagaccuaca ucugcaacgu gaaccacaag cccagcaaca ccaaggugga caagagagug      720

gagcccaaga gcugcgacaa gacccacacc ugcccccccu gccccgcccc cgagcugcug      780

ggcggcccca gcguguuccu guuccccccc aagcccaagg acacccugau gaucagcaga      840

acccccgagg ugaccugcgu ggugguggac gugagccacg aggaccccga ggugaaguuc      900

aacugguacg uggacggcgu ggaggugcac aacgccaaga ccaagcccag agaggagcag      960

uacaacagca ccuacagagu ggugagcgug cugaccgugc ugcaccagga cuggcugaac     1020

ggcaaggagu acaagugcaa ggugagcaac aaggcccugc ccgcccccau cgagaagacc     1080

aucagcaagg ccaagggcca gcccagagag ccccaggugu acacccugcc ccccagcaga     1140

gacgagcuga ccaagaacca ggugagccug accugccugg ugaagggcuu cuaccccagc     1200

gacaucgccg uggaguggga gagcaacggc cagcccgaga acaacuacaa gaccaccccc     1260

cccgugcugg acagcgacgg cagcuucuuc cuguacagca agcugaccgu ggacaagagc     1320

agauggcagc agggcaacgu guucagcugc agcgugaugc acgaggcccu gcacaaccac     1380

uacacccaga agagccugag ccugagcccc ggcaagguga agcagacacu caauuucgac     1440

cuucugaagu uggcuggaga uguugagucu aacccaggcc ccauggagac ccccgcccag     1500

cugcuguucc ugcugcugcu guggcugccc gacaccaccg gcgagaucgu gcugacccag     1560

agccccggca cccugagccu gagccccggc gagagagcca cccugagcug cagagccagc     1620

cagagcgugg gcagcagcua ccuggccugg uaccagcaga agcccggcca ggcccccaga     1680

cugcugaucu acggcgccuu cagcagagcc accggcaucc ccgacagauu cagcggcagc     1740

ggcagcggca ccgacuucac ccugaccauc agcagacugg agcccgagga cuucgccgug     1800

uacuacugcc agcaguacgg cagcagcccc uggaccuucg gccagggcac caagguggag     1860

aucaagagaa ccguggccgc ccccagcgug uucaucuucc cccccagcga cgagcagcug     1920

aagagcggca ccgccagcgu ggugugccug cugaacaacu ucuaccccag agaggccaag     1980

gugcagugga agguggacaa cgcccugcag agcggcaaca gccaggagag cgugaccgag     2040

caggacagca aggacagcac cuacagccug agcagcaccc ugacccugag caaggccgac     2100

uacgagaagc acaaggugua cgccugcgag gugacccacc agggccugag cagccccgug     2160

accaagagcu ucaacagagg cgagugcuga ggacuaguua uaagacugac uagcccgaug     2220

ggccucccaa cgggcccucc uccccuccuu gcaccgagau uaauaaaaaa aaaaaaaaaa     2280

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaug cauccccccc     2340

cccccccccc cccccccccc ccccaaaggc ucuuuucaga gccaccagaa uu             2392


<210>  992
<211>  1849
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  IL12_opt1_gen4

<400>  992
gggagaaagc uuaccaugug ccaccagcag cuggugauca gcugguucuc ccucgucuuc       60

cuggccagcc cccugguggc caucugggag cucaagaagg acguguacgu cguggagcug      120

gacugguacc cggacgcgcc cggcgagaug gugguccuga ccugcgacac ccccgaggag      180

gacgggauca cguggacccu cgaccagucc agcgaggugc ugggcuccgg gaagacccug      240

accauccagg ugaaggaguu cggcgacgcc gggcaguaca cgugccacaa gggcggcgag      300

guccucagcc acucccugcu gcuccugcac aagaaggagg acgggaucug gagcaccgac      360

auccugaagg accagaagga gcccaagaac aagaccuucc uccgcugcga ggccaagaac      420

uacuccggcc gguucacgug cugguggcug accaccauca gcaccgaccu gaccuucucc      480

gucaagagcu cccgcgggag cuccgacccg cagggcguga cgugcggggc cgccacccuc      540

agcgcggagc gggugcgcgg cgacaacaag gaguacgagu acuccgugga gugccaggag      600

gacagcgccu gccccgccgc cgaggagucc cugcccaucg aggugauggu cgacgcggug      660

cacaagcuga aguacgagaa cuacaccagc agcuucuuca uccgggacau caucaagccc      720

gacccgccca agaaccucca gcugaagccc cugaagaacu cccgccaggu ggaggucagc      780

ugggaguacc ccgacaccug guccacgccg cacagcuacu ucucccucac cuucugcguc      840

caggugcagg gcaagagcaa gcgggagaag aaggaccgcg uguucaccga caagaccucc      900

gccacgguga ucugccggaa gaacgccagc aucuccgugc gcgcccagga ccgguacuac      960

agcuccagcu gguccgagug ggccagcguc cccugcuccg gcagcaccuc cgggagcggc     1020

aagcccgggu ccggcgaggg gagcaccaag ggccggaacc ugccgguggc cacccccgac     1080

cccggcaugu uccccugccu gcaccacagc cagaaccucc ugcgcgccgu guccaacaug     1140

cugcagaagg cccggcagac gcucgaguuc uacccgugca ccagcgagga gaucgaccac     1200

gaggacauca ccaaggacaa gaccuccacg gucgaggccu gccugccccu ggagcucacc     1260

aagaacgaga gcugccugaa cucccgcgag accagcuuca ucaccaacgg guccugccug     1320

gcgagccgga agacguccuu caugauggcc cucugccuga gcuccaucua cgaggaccug     1380

aagauguacc agguggaguu caagaccaug aacgccaagc uccugaugga ccccaagcgc     1440

cagaucuucc uggaccagaa caugcucgcc gugaucgacg agcugaugca ggcgcugaac     1500

uucaacagcg agaccguccc ccagaagucc agccucgagg agccggacuu cuacaagacc     1560

aagaucaagc ugugcauccu gcuccacgcc uuccggaucc gcgccgugac gaucgaccgg     1620

gugauguccu accugaacgc cagcugagga cuaguuauaa gacugacuag cccgaugggc     1680

cucccaacgg gcccuccucc ccuccuugca ccgagauuaa uaaaaaaaaa aaaaaaaaaa     1740

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaugcau cccccccccc     1800

cccccccccc cccccccccc caaaggcucu uuucagagcc accagaauu                 1849


<210>  993
<211>  2014
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  IL12_opt1_gen5

<400>  993
ggggcgcugc cuacggaggu ggcagccauc uccuucucgg caucaagcuu accaugugcc       60

accagcagcu ggugaucagc ugguucuccc ucgucuuccu ggccagcccc cugguggcca      120

ucugggagcu caagaaggac guguacgucg uggagcugga cugguacccg gacgcgcccg      180

gcgagauggu gguccugacc ugcgacaccc ccgaggagga cgggaucacg uggacccucg      240

accaguccag cgaggugcug ggcuccggga agacccugac cauccaggug aaggaguucg      300

gcgacgccgg gcaguacacg ugccacaagg gcggcgaggu ccucagccac ucccugcugc      360

uccugcacaa gaaggaggac gggaucugga gcaccgacau ccugaaggac cagaaggagc      420

ccaagaacaa gaccuuccuc cgcugcgagg ccaagaacua cuccggccgg uucacgugcu      480

gguggcugac caccaucagc accgaccuga ccuucuccgu caagagcucc cgcgggagcu      540

ccgacccgca gggcgugacg ugcggggccg ccacccucag cgcggagcgg gugcgcggcg      600

acaacaagga guacgaguac uccguggagu gccaggagga cagcgccugc cccgccgccg      660

aggagucccu gcccaucgag gugauggucg acgcggugca caagcugaag uacgagaacu      720

acaccagcag cuucuucauc cgggacauca ucaagcccga cccgcccaag aaccuccagc      780

ugaagccccu gaagaacucc cgccaggugg aggucagcug ggaguacccc gacaccuggu      840

ccacgccgca cagcuacuuc ucccucaccu ucugcgucca ggugcagggc aagagcaagc      900

gggagaagaa ggaccgcgug uucaccgaca agaccuccgc cacggugauc ugccggaaga      960

acgccagcau cuccgugcgc gcccaggacc gguacuacag cuccagcugg uccgaguggg     1020

ccagcguccc cugcuccggc agcaccuccg ggagcggcaa gcccgggucc ggcgagggga     1080

gcaccaaggg ccggaaccug ccgguggcca cccccgaccc cggcauguuc cccugccugc     1140

accacagcca gaaccuccug cgcgccgugu ccaacaugcu gcagaaggcc cggcagacgc     1200

ucgaguucua cccgugcacc agcgaggaga ucgaccacga ggacaucacc aaggacaaga     1260

ccuccacggu cgaggccugc cugccccugg agcucaccaa gaacgagagc ugccugaacu     1320

cccgcgagac cagcuucauc accaacgggu ccugccuggc gagccggaag acguccuuca     1380

ugauggcccu cugccugagc uccaucuacg aggaccugaa gauguaccag guggaguuca     1440

agaccaugaa cgccaagcuc cugauggacc ccaagcgcca gaucuuccug gaccagaaca     1500

ugcucgccgu gaucgacgag cugaugcagg cgcugaacuu caacagcgag accguccccc     1560

agaaguccag ccucgaggag ccggacuucu acaagaccaa gaucaagcug ugcauccugc     1620

uccacgccuu ccggauccgc gccgugacga ucgaccgggu gauguccuac cugaacgcca     1680

gcugaggacu agugcaucac auuuaaaagc aucucagccu accaugagaa uaagagaaag     1740

aaaaugaaga ucaauagcuu auucaucucu uuuucuuuuu cguuggugua aagccaacac     1800

ccugucuaaa aaacauaaau uucuuuaauc auuuugccuc uuuucucugu gcuucaauua     1860

auaaaaaaug gaaagaaccu agaucuaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa     1920

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa ugcauccccc cccccccccc cccccccccc     1980

ccccccaaag gcucuuuuca gagccaccag aauu                                 2014


<210>  994
<211>  42
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  1368_5UTR

<400>  994
ggcgcugccu acggaggugg cagccaucuc cuucucggca uc                          42


<210>  995
<211>  34
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  1412_5UTR

<400>  995
ggagcgggcg gcggcguugg cggcuugugc agca                                   34


<210>  996
<211>  34
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  1413_5UTR

<400>  996
ggccggaacc gccaucuucc aguaauucgc caaa                                   34


<210>  997
<211>  75
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  1414_5UTR

<400>  997
gcggcucggc cauuuugucc cagucagucc ggaggcugcg gcugcagaag uaccgccugc       60

ggaguaacug caaag                                                        75


<210>  998
<211>  62
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  1415_5UTR

<400>  998
gucccgcagu cggcguccag cggcucugcu uguucgugug ugugucguug caggccuuau       60

uc                                                                      62


<210>  999
<211>  31
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  1416_5UTR

<400>  999
gccgcccagc cgguccaggc cucuggcgaa c                                      31


<210>  1000
<211>  56
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  1417_5UTR

<400>  1000
agucaggaag gacguuggug uugagguuag cauacguauc aaggacagua acuacc           56


<210>  1001
<211>  42
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  1418_5UTR

<400>  1001
gccucugcug gaguccgggg aguggcguug gcugcuagag cg                          42


<210>  1002
<211>  34
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  1419_5UTR

<400>  1002
ggccgccgca gccaucuucc aguaacucgc caaa                                   34


<210>  1003
<211>  53
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  1420_5UTR

<400>  1003
gccaucuugg cgccugugga ggccugcugg gaacaggacu ucuaacagca agu              53


<210>  1004
<211>  42
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  1368_5UTR

<400>  1004
ggcgctgcct acggaggtgg cagccatctc cttctcggca tc                          42


<210>  1005
<211>  34
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  1412_5UTR

<400>  1005
ggagcgggcg gcggcgttgg cggcttgtgc agca                                   34


<210>  1006
<211>  34
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  1413_5UTR

<400>  1006
ggccggaacc gccatcttcc agtaattcgc caaa                                   34


<210>  1007
<211>  75
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  1414_5UTR

<400>  1007
gcggctcggc cattttgtcc cagtcagtcc ggaggctgcg gctgcagaag taccgcctgc       60

ggagtaactg caaag                                                        75


<210>  1008
<211>  62
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  1415_5UTR

<400>  1008
gtcccgcagt cggcgtccag cggctctgct tgttcgtgtg tgtgtcgttg caggccttat       60

tc                                                                      62


<210>  1009
<211>  31
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  1416_5UTR

<400>  1009
gccgcccagc cggtccaggc ctctggcgaa c                                      31


<210>  1010
<211>  56
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  1417_5UTR

<400>  1010
agtcaggaag gacgttggtg ttgaggttag catacgtatc aaggacagta actacc           56


<210>  1011
<211>  42
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  1418_5UTR

<400>  1011
gcctctgctg gagtccgggg agtggcgttg gctgctagag cg                          42


<210>  1012
<211>  34
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  1419_5UTR

<400>  1012
ggccgccgca gccatcttcc agtaactcgc caaa                                   34


<210>  1013
<211>  53
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  1420_5UTR

<400>  1013
gccatcttgg cgcctgtgga ggcctgctgg gaacaggact tctaacagca agt              53


<210>  1014
<211>  547
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  R3630_(a249g)_Ndel

<400>  1014
gggagaaagc ucaagcuuau ccaaguaggc uggucaccug uacaacguag ccgguauuuu       60

uuuuuuuuuu uuuuuuuuga ccgucucaag guccaaguua gucugccuau aaaggugcgg      120

auccacagcu gaugaaagac uugugcggua cgguuaaucu ccccuuuuuu uuuuuuuuuu      180

uuuuuaguaa augcgucuac ugaauccagc gaugaugcug gcccagaucu ucgaccacaa      240

gugcauaugg uagucaucga gggucgccuu uuuuuuuuuu uuuuuuuuuu uggcccaguu      300

cugagacuuc gcuagagacu acaguuacag cugcaguagu aaccacugcg gcuauugcag      360

gaaaucccgu ucagguuuuu uuuuuuuuuu uuuuuuccgc ucacuaugau uaagaaccag      420

guggaguguc acugcucucg aggucucacg agagcgcucg auacagugcu uggaagaauc      480

uuuuuuuuuu uuuuuuuuuu uugugcgacg aucacagaga acuucuauuc augcaggucu      540

gcucuag                                                                547


<210>  1015
<211>  547
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  R3630_(g241a)_Nsil

<400>  1015
gggagaaagc ucaagcuuau ccaaguaggc uggucaccug uacaacguag ccgguauuuu       60

uuuuuuuuuu uuuuuuuuga ccgucucaag guccaaguua gucugccuau aaaggugcgg      120

auccacagcu gaugaaagac uugugcggua cgguuaaucu ccccuuuuuu uuuuuuuuuu      180

uuuuuaguaa augcgucuac ugaauccagc gaugaugcug gcccagaucu ucgaccacaa      240

augcauauag uagucaucga gggucgccuu uuuuuuuuuu uuuuuuuuuu uggcccaguu      300

cugagacuuc gcuagagacu acaguuacag cugcaguagu aaccacugcg gcuauugcag      360

gaaaucccgu ucagguuuuu uuuuuuuuuu uuuuuuccgc ucacuaugau uaagaaccag      420

guggaguguc acugcucucg aggucucacg agagcgcucg auacagugcu uggaagaauc      480

uuuuuuuuuu uuuuuuuuuu uugugcgacg aucacagaga acuucuauuc augcaggucu      540

gcucuag                                                                547


<210>  1016
<211>  547
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  R3630_no_BglII

<400>  1016
gggagaaagc ucaagcuuau ccaaguaggc uggucaccug uacaacguag ccgguauuuu       60

uuuuuuuuuu uuuuuuuuga ccgucucaag guccaaguua gucugccuau aaaggugcgg      120

auccacagcu gaugaaagac uugugcggua cgguuaaucu ccccuuuuuu uuuuuuuuuu      180

uuuuuaguaa augcgucuac ugaauccagc gaugaugcug gcccagauca ucgaccacaa      240

gugcauauag uagucaucga gggucgccuu uuuuuuuuuu uuuuuuuuuu uggcccaguu      300

cugagacuuc gcuagagacu acaguuacag cugcaguagu aaccacugcg gcuauugcag      360

gaaaucccgu ucagguuuuu uuuuuuuuuu uuuuuuccgc ucacuaugau uaagaaccag      420

guggaguguc acugcucucg aggucucacg agagcgcucg auacagugcu uggaagaauc      480

uuuuuuuuuu uuuuuuuuuu uugugcgacg aucacagaga acuucuauuc augcaggucu      540

gcucuag                                                                547


<210>  1017
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  W(Arg12)Cys

<400>  1017

Trp Arg Arg Arg Arg Arg Arg Arg Arg Arg Arg Arg Arg Cys 
1               5                   10                  


<210>  1018
<211>  987
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  IL12B

<400>  1018
augugccacc aacaacucgu caucuccugg uucucccucg ucuuccuagc cuccccacuc       60

gucgccaucu gggaacucaa aaaagacgua uacgucgucg aacucgacug guaccccgac      120

gccccaggag aaauggucgu cuuaaccugc gacacacccg aagaagacgg uaucaccugg      180

acccucgacc aauccuccga aguccuaggc uccggcaaga cccucaccau ccaagucaaa      240

gaauuuggcg acgcaggaca auacaccugu cacaaaggcg gcgaaguccu cagccacagc      300

cuucuccuac uccauaaaaa agaagacggc aucuggucca cugacauccu caaagaccaa      360

aaagaaccca aaaauaaaac cuuccuccgc ugcgaagcca aaaacuacuc cggccgauuu      420

accuguuggu ggcuaaccac aaucagcacc gaccucaccu ucucagucaa auccucccgc      480

ggcucaucug acccccaagg cgucacaugc ggcgccgcca ccuuauccgc cgaacgcguc      540

cgcggcgaca acaaagaaua cgaauacucc gucgaauguc aagaagauuc cgccugcccc      600

gccgccgaag aaucacuccc caucgaaguc auggucgacg caguccacaa acucaaauac      660

gaaaacuaca ccuccuccuu cuucauccgc gacauaauaa aacccgaccc acccaaaaac      720

cuccaacuca aaccacucaa aaacucccga caagucgaag ucuccuggga guaccccgac      780

accuggucca caccacacuc cuacuucucc cucaccuucu gcguccaagu ccaaggcaaa      840

uccaaacgcg aaaaaaaaga ccgcguuuuc acagacaaaa ccuccgccac aguaauaugc      900

cgcaaaaacg ccuccaucuc cguccgggcc caagaccgcu acuacuccuc cuccuggucc      960

gagugggccu caguccccug cagcuga                                          987


<210>  1019
<211>  987
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  IL12B

<400>  1019
augugccacc aacaacucgu caucuccugg uucucccucg ucuuccuagc cuccccacuc       60

gucgccaucu gggaacucaa aaaagacgua uacgucgucg aacucgacug guaccccgac      120

gccccaggag aaauggucgu ccuaaccugc gacacacccg aagaagacgg uaucaccugg      180

acccucgacc aauccuccga aguccuaggc uccggcaaga cccucaccau ccaagucaaa      240

gaauuuggcg acgcaggaca auacaccugu cacaaaggcg gcgaaguccu cagccacagc      300

cuucuccuac uccauaaaaa agaagacggc aucuggucca cugacauccu caaagaccaa      360

aaagaaccca aaaauaaaac cuuccuccgc ugcgaagcca aaaacuacuc cggccgauuc      420

accuguuggu ggcuaaccac aaucagcacc gaccucaccu ucucagucaa auccucccgc      480

ggcucaucug acccccaagg cgucacaugc ggcgccgcca cccucuccgc cgaacgcguc      540

cgcggcgaca acaaagaaua cgaauacucc gucgaauguc aagaagacuc cgccugcccc      600

gccgccgaag aaucacuccc caucgaaguc auggucgacg caguccacaa acucaaauac      660

gaaaacuaca ccuccuccuu cuucauccgc gacauaauaa aacccgaccc acccaaaaac      720

cuccaacuca agccacucaa aaacucccga caagucgaag ucuccuggga guaccccgac      780

accuggucca caccacacuc cuacuucucc cucaccuucu gcguccaagu ccaaggcaaa      840

uccaaacgcg aaaaaaaaga ccgcguuuuc acagacaaaa ccuccgccac aguaauaugc      900

cgcaaaaacg ccuccaucuc cguccgggcc caagaccgcu acuacuccuc cuccuggucc      960

gagugggccu caguccccug cagcuga                                          987


<210>  1020
<211>  987
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  IL12B

<400>  1020
augugccacc aacaacucgu caucuccugg uucucccucg ucuuccuagc cuccccacuc       60

gucgccaucu gggaacucaa aaaagacgua uacgucgucg aacucgacug guaccccgac      120

gccccaggag aaauggucgu ccuaaccugc gacacacccg aagaagacgg uaucaccugg      180

acccucgacc aauccuccga aguccuaggc uccggcaaga cccucaccau ccaagucaaa      240

gaauuuggcg acgcaggaca auacaccugu cacaaaggcg gcgaaguccu cagccacagc      300

cuucuccuac uccauaaaaa agaagacggc aucuggucca cugacauccu caaagaccaa      360

aaagaaccca aaaauaaaac cuuccuccgc ugcgaagcca aaaacuacuc cggccgauuc      420

accuguuggu ggcuaaccac aaucagcacc gaccucaccu ucucagucaa auccucccgc      480

ggcucaucug acccccaagg cgucacaugc ggcgccgcca cccucuccgc cgaacgcguc      540

cgcggcgaca acaaagaaua cgaauacucc gucgaauguc aagaagacuc cgccugcccc      600

gccgccgaag aaucacuccc caucgaaguc auggucgacg caguccacaa acucaaauac      660

gaaaacuaca ccuccuccuu cuucauccgc gacauaauaa aacccgaccc acccaaaaac      720

cuccaacuca agccacucaa aaacucccga caagucgaag ucuccuggga guaccccgac      780

accuggucca caccacacuc cuacuucucc cucaccuucu gcguccaagu ccaaggcaaa      840

uccaaacgcg aaaaaaaaga ccgcguuuuc acagacaaaa ccuccgccac aguaauaugc      900

cgcaaaaacg ccuccaucuc cguccgggcc caagaccgcu acuacuccuc cuccuggucc      960

gagugggccu caguccccug cagcuga                                          987


<210>  1021
<211>  987
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  IL12B

<400>  1021
augugccacc aacaacucgu caucuccugg uucucccucg ucuuccuagc cuccccacuc       60

gucgccaucu gggaacucaa aaaagacgua uacgucgucg aacucgacug guaccccgac      120

gccccaggag aaauggucgu ccuaaccugc gacacacccg aagaagacgg uaucaccugg      180

acccucgacc aauccuccga aguccuaggc uccggcaaga cccucaccau ccaagucaaa      240

gaauuuggcg acgcaggaca auacaccugu cacaaaggcg gcgaaguccu cagccacagc      300

cuucuccuac uccauaaaaa agaagacggc aucuggucca cugacauccu caaagaccaa      360

aaagaaccca aaaauaaaac cuuccuccgc ugcgaagcca aaaacuacuc cggccgauuc      420

accuguuggu ggcuaaccac aaucagcacc gaccucaccu ucucagucaa auccucccgc      480

ggcucaucug acccccaagg cgucacaugc ggcgccgcca cccucuccgc cgaacgcguc      540

cgcggcgaca acaaagaaua cgaauacucc gucgaauguc aagaagacuc cgccugcccc      600

gccgccgaag aaucacuccc caucgaaguc auggucgacg caguccacaa acucaaauac      660

gaaaacuaca ccuccuccuu cuucauccgc gacauaauaa aacccgaccc acccaaaaac      720

cuccaacuca agccacucaa aaacucccga caagucgaag ucuccuggga guaccccgac      780

accuggucca caccacacuc cuacuucucc cucaccuucu gcguccaagu ccaaggcaaa      840

uccaaacgcg aaaaaaaaga ccgcguuuuc acagacaaaa ccuccgccac aguaauaugc      900

cgcaaaaacg ccuccaucuc cguccgggcc caagaccgcu acuacuccuc cuccuggucc      960

gagugggccu caguccccug cagcuga                                          987


<210>  1022
<211>  867
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  PDCD1

<400>  1022
augcaaauac cccaagcccc cuggccgguc gucugggccg uccuccaacu cggcuggcgc       60

cccggauggu uccucgauuc ccccgaccgc ccguggaauc cgcccaccuu cucccccgcc      120

cucuuagucg ucaccgaagg cgacaacgcg accuucaccu guuccuuuuc gaacaccuca      180

gaauccuucg uccucaacug guaccgcaug ucccccucca accaaaccga caaacucgcc      240

gccuuccccg aagaccgauc ccaacccggc caagauugcc gcuuccgcgu cacacaauua      300

cccaauggac gcgacuuuca cauguccguc guccgcgccc gccgcaacga cuccggcacc      360

uaccucugcg gcgccaucuc guuagccccc aaagcccaaa ucaaagaauc gcucagagcc      420

gaauuacgcg ucaccgaacg gcgcgccgaa guccccacug cgcaccccuc ccccucgccc      480

cgccccgccg gccaauucca aacccucguc gucggcguug ucggcggcuu auuaggcuca      540

cucguccucc ucgucugggu acucgccguc aucugcuccc gcgccgcgcg cggcaccauc      600

ggcgcgcgcc gcaccggaca acccuuaaaa gaagaccccu ccgccguccc cgucuucucc      660

gucgacuacg gcgaacucga cuuccaaugg cgcgaaaaaa cgccggaacc acccgucccg      720

ugcguccccg aacaaacaga auacgcgacc aucgucuucc cguccggcau gggcacaucc      780

ucacccgccc gccgaggcuc cgccgacggc ccccgauccg cccaacccuu acgccccgaa      840

gacggccacu gcuccuggcc cuuauga                                          867


<210>  1023
<211>  867
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  PDCD1

<400>  1023
augcaaaucc cccaagcccc cuggccgguc gucugggccg uccuccaacu cggcuggcgc       60

cccggauggu uccucgacuc ccccgaccgc ccguggaauc cgcccaccuu cucccccgcc      120

cucuuagucg ucaccgaagg cgacaacgcg accuucaccu guuccuucuc gaacaccuca      180

gaauccuucg uccucaacug guaccgcaug ucccccucca accaaaccga caaacucgcc      240

gccuuccccg aagaccgauc ccaacccggc caagacugcc gcuuccgcgu cacacaauua      300

cccaauggac gcgacuuuca cauguccguc guccgcgccc gccgcaacga cuccggcacc      360

uaccucugcg gcgccaucuc guuagccccc aaagcccaaa ucaaagaauc gcucagagcc      420

gaauuacgcg ucaccgaacg gcgcgccgaa guccccacug cgcaccccuc ccccucgccc      480

cgccccgccg gccaauucca aacccucguc gucggcguug ucggcggcuu auuaggcuca      540

cucguccucc ucgucugggu acucgccguc aucugcuccc gcgccgcgcg cggcaccauc      600

ggcgcgcgcc gcaccggaca acccuuaaaa gaagaccccu ccgccguccc cgucuucucc      660

gucgacuacg gcgaacucga cuuccaaugg cgcgaaaaaa cgccggaacc acccgucccg      720

ugcguccccg aacaaacaga auacgcgacc aucgucuucc cguccggcau gggcacaucc      780

ucacccgccc gccgaggcuc cgccgacggc ccccgauccg cccaacccuu acgccccgaa      840

gacggccacu gcuccuggcc ccucuga                                          867


<210>  1024
<211>  867
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  PDCD1

<400>  1024
augcaaaucc cccaagcccc cuggccgguc gucugggccg uccuccaacu cggcuggcgc       60

cccggauggu uccucgacuc ccccgaccgc ccguggaauc cgcccaccuu cucccccgcc      120

cucuuagucg ucaccgaagg cgacaacgcg accuucaccu guuccuucuc gaacaccuca      180

gaauccuucg uccucaacug guaccgcaug ucccccucca accaaaccga caaacucgcc      240

gccuuccccg aagaccgauc ccaacccggc caagacugcc gcuuccgcgu cacacaauua      300

cccaacggac gcgacuuuca cauguccguc guccgcgccc gccgcaacga cuccggcacc      360

uaccucugcg gcgccaucuc gcucgccccc aaagcccaaa ucaaagaauc gcucagagcc      420

gaacuccgcg ucaccgaacg gcgcgccgaa guccccacug cgcaccccuc ccccucgccc      480

cgccccgccg gccaauucca aacccucguc gucggcguug ucggcggccu cuuaggcuca      540

cucguccucc ucgucugggu acucgccguc aucugcuccc gcgccgcgcg cggcaccauc      600

ggcgcgcgcc gcaccggaca acccuuaaaa gaagaccccu ccgccguccc cgucuucucc      660

gucgacuacg gcgaacucga cuuccaaugg cgcgaaaaaa cgccggaacc acccgucccg      720

ugcguccccg aacaaacaga auacgcgacc aucgucuucc cguccggcau gggcacaucc      780

ucacccgccc gccgaggcuc cgccgacggc ccccgauccg cccaacccuu acgccccgaa      840

gacggccacu gcuccuggcc ccucuga                                          867


<210>  1025
<211>  786
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  CD40LG

<400>  1025
augaucgaaa ccuacaauca aaccucgccc cgcagcgccg caacaggccu ccccaucucc       60

augaaaaucu ucauguaccu ccucaccguc uuccuaauca cccaaaugau cggcuccgcc      120

uuauucgccg ucuaccucca ccgccgccuc gacaaaaucg aagacgaacg caaccuccac      180

gaagacuuug ucuucaugaa aacuauccaa cgaugcaaca ccggcgaacg aucccuaucc      240

cucuuaaacu gcgaagaaau aaaaucgcaa uucgaaggau ucgucaaaga caucaugcua      300

aacaaagaag aaaccaaaaa agaaaauucc uucgaaaugc aaaaaggcga ccaaaacccc      360

caaaucgcag cccacgucau cucagaagca ucuuccaaaa ccaccuccgu ccuccaaugg      420

gccgaaaaag gcuacuacac caugucaaac aaccucguca cgcucgaaaa cggcaaacaa      480

cucaccguca aacgccaagg cuuauacuac aucuacgcac aagucaccuu cugcuccaac      540

cgcgaagcau ccucccaagc ccccuucauc gccucccucu gucucaaauc ccccggccgc      600

uucgaacgca uccuccuccg cgccgcaaau acccauuccu ccgccaaacc augcggccaa      660

caauccaucc accucggcgg cgucuucgaa cuccaacccg gcgccuccgu cuucgucaac      720

gucaccgacc ccucccaagu aucccaugga accggcuuca ccuccuucgg ccuccucaaa      780

cucuga                                                                 786


<210>  1026
<211>  786
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  CD40LG

<400>  1026
augaucgaaa ccuacaauca aaccucgccc cgcagcgccg caacaggccu ccccaucucc       60

augaaaaucu ucauguaccu ccucaccguc uuccuaauca cccaaaugau cggcuccgcc      120

uuauucgccg ucuaccucca ccgccgccuc gacaaaaucg aagacgaacg caaccuccac      180

gaagacuuug ucuucaugaa aacuauccaa cgaugcaaca ccggcgaacg aucccuaucc      240

cuccucaacu gcgaagaaau aaaaucgcaa uucgaaggau ucgucaaaga caucaugcua      300

aacaaagaag aaaccaaaaa agaaaacucc uucgaaaugc aaaaaggcga ccaaaacccc      360

caaaucgcag cccacgucau cucagaagca ucuuccaaaa ccaccuccgu ccuccaaugg      420

gccgaaaaag gcuacuacac caugucaaac aaccucguca cgcucgaaaa cggcaaacaa      480

cucaccguca aacgccaagg ccucuacuac aucuacgcac aagucaccuu cugcuccaac      540

cgcgaagcau ccucccaagc ccccuucauc gccucccucu gccucaaauc ccccggccgc      600

uucgaacgca uccuccuccg cgccgcaaau acccauuccu ccgccaaacc augcggccaa      660

caauccaucc accucggcgg cgucuucgaa cuccaacccg gcgccuccgu cuucgucaac      720

gucaccgacc ccucccaagu aucccaugga accggcuuca ccuccuucgg ccuccucaaa      780

cucuga                                                                 786


<210>  1027
<211>  786
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  CD40LG

<400>  1027
augaucgaaa ccuacaauca aaccucgccc cgcagcgccg caacaggccu ccccaucucc       60

augaaaaucu ucauguaccu ccucaccguc uuccuaauca cccaaaugau cggcuccgcc      120

cuauucgccg ucuaccucca ccgccgccuc gacaaaaucg aagacgaacg caaccuccac      180

gaagacuuug ucuucaugaa aacuauccaa cgaugcaaca ccggcgaacg aucccuaucc      240

cuccucaacu gcgaagaaau aaaaucccaa uucgaaggau ucgucaaaga caucaugcua      300

aacaaagaag aaaccaaaaa agaaaacucc uucgaaaugc aaaaaggcga ccaaaacccc      360

caaaucgcag cccacgucau cucagaagca ucuuccaaaa ccaccuccgu ccuccaaugg      420

gccgaaaaag gcuacuacac caugucaaac aaccucguca cccucgaaaa cggcaaacaa      480

cucaccguca aacgccaagg ccucuacuac aucuacgcac aagucaccuu cugcuccaac      540

cgcgaagcau ccucccaagc ccccuucauc gccucccucu gccucaaauc ccccggccgc      600

uucgaacgca uccuccuccg cgccgcaaau acccacuccu ccgccaaacc augcggccaa      660

caauccaucc accucggcgg cgucuucgaa cuccaacccg gcgccuccgu cuucgucaac      720

gucaccgacc ccucccaagu aucccaugga accggcuuca ccuccuucgg ccuccucaaa      780

cucuga                                                                 786


<210>  1028
<211>  786
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  CD40LG

<400>  1028
augaucgaaa ccuacaauca aaccucgccc cgcagcgccg caacaggccu ccccaucucc       60

augaaaaucu ucauguaccu ccucaccguc uuccuaauca cccaaaugau cggcuccgcc      120

cuauucgccg ucuaccucca ccgccgccuc gacaaaaucg aagacgaacg caaccuccac      180

gaagacuuug ucuucaugaa aacuauccaa cgaugcaaca ccggcgaacg aucccuaucc      240

cuccucaacu gcgaagaaau aaaaucccaa uucgaaggau ucgucaaaga caucaugcua      300

aacaaagaag aaaccaaaaa agaaaacucc uucgaaaugc aaaaaggcga ccaaaacccc      360

caaaucgcag cccacgucau cucagaagca ucuuccaaaa ccaccuccgu ccuccaaugg      420

gccgaaaaag gcuacuacac caugucaaac aaccucguca cccucgaaaa cggcaaacaa      480

cucaccguca aacgccaagg ccucuacuac aucuacgcac aagucaccuu cugcuccaac      540

cgcgaagcau ccucccaagc ccccuucauc gccucccucu gccucaaauc ccccggccgc      600

uucgaacgca uccuccuccg cgccgcaaau acccacuccu ccgccaaacc augcggccaa      660

caauccaucc accucggcgg cgucuucgaa cuccaacccg gcgccuccgu cuucgucaac      720

gucaccgacc ccucccaagu aucccaugga accggcuuca ccuccuucgg ccuccucaaa      780

cucuga                                                                 786


<210>  1029
<211>  1347
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Ipilimumab_HC

<400>  1029
caggugcagu uagucgaguc gggcgggggc guggugcagc ccgggcgcuc ccuccgguua       60

ucgugcgccg ccuccggcuu caccuucucg uccuacacca ugcacugggu ccgccaggcg      120

ccggggaagg gcuuagagug ggugacguuc aucucguacg acggcaacaa caaguacuac      180

gccgacuccg ugaaggggcg guucaccauc ucgcgcgaca acuccaagaa cacccucuac      240

uuacagauga acucguuacg ggccgaggac accgccaucu acuacugcgc ccgcacgggc      300

uggcucgggc ccuucgacua cuggggccag gggaccuuag ucaccguguc cucggcgucc      360

accaagggcc ccucgguguu ccccuuagcc ccguccucga aguccacguc gggcgggacc      420

gccgcccucg gcugcuuagu caaggacuac uuccccgagc ccgugaccgu guccuggaac      480

ucgggggcgu uaaccucggg cguccacacg uuccccgccg ugcuccaguc cucgggcuua      540

uacuccuuau cgucggucgu cacggucccg ucgucgucgc ucgggacgca gacguacauc      600

ugcaacguca accacaagcc gucgaacacg aaggucgaca agcgggucga gccgaagucg      660

ugcgacaaga cgcacacgug cccgccgugc ccggcgccgg aguuauuagg ggggccgucg      720

gucuuccucu ucccgccgaa gccgaaggac acguuaauga ucucgcgcac gccggagguc      780

acgugcgucg ucgucgacgu cucgcacgag gacccggagg ucaaguucaa cugguacguc      840

gacggggucg agguccacaa cgcgaagacg aagccgcggg aggagcagua caacucgacg      900

uaccgcgucg ucucggucuu aacgguccuc caccaggacu gguuaaacgg gaaggaguac      960

aagugcaagg ucucgaacaa ggcguuaccg gcgccgaucg agaagacgau cucgaaggcg     1020

aaggggcagc cgcgggagcc gcaggucuac acgcucccgc cgucgcgcga cgaguuaacg     1080

aagaaccagg ucucguuaac gugccucguc aagggguucu acccgucgga caucgcgguc     1140

gagugggagu cgaacgggca gccggagaac aacuacaaga cgacgccgcc ggucuuagac     1200

ucggacgggu cguucuucuu auacucgaag cucacggucg acaagucgcg guggcagcag     1260

gggaacgucu ucucgugcuc ggucaugcac gaggcguuac acaaccacua cacgcagaag     1320

ucguuaucgc ucucgccggg gaaguga                                         1347


<210>  1030
<211>  1347
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Ipilimumab_HC

<400>  1030
caggugcagu uagucgaguc gggcgggggc guggugcagc ccgggcgcuc ccuccgguua       60

ucgugcgccg ccuccggcuu caccuucucg uccuacacca ugcacugggu ccgccaggcg      120

ccggggaagg gcuuagagug ggugacguuc aucucguacg acggcaacaa caaguacuac      180

gccgacuccg ugaaggggcg guucaccauc ucgcgcgaca acuccaagaa cacccucuac      240

uuacagauga acucguuacg ggccgaggac accgccaucu acuacugcgc ccgcacgggc      300

uggcucgggc ccuucgacua cuggggccag gggaccuuag ucaccguguc cucggcgucc      360

accaagggcc ccucgguguu ccccuuagcc ccguccucga aguccacguc gggcgggacc      420

gccgcccucg gcugcuuagu caaggacuac uuccccgagc ccgugaccgu guccuggaac      480

ucgggggcgu uaaccucggg cguccacacg uuccccgccg ugcuccaguc cucgggcuua      540

uacuccuuau cguccguggu caccgugccg ucguccucgc ucgggaccca gaccuacauc      600

ugcaacguca accacaagcc gucgaacacg aaggucgaca agcgggucga gccgaagucg      660

ugcgacaaga cgcacacgug cccgccgugc ccggcgccgg aguuauuagg ggggccgucg      720

gucuuccucu ucccgccgaa gccgaaggac acguuaauga ucucgcgcac gccggagguc      780

acgugcgucg ucgucgacgu cucgcacgag gacccggagg ucaaguucaa cugguacguc      840

gacggggucg agguccacaa cgcgaagacg aagccgcggg aggagcagua caacucgacg      900

uaccgcgucg ucucggucuu aacgguccuc caccaggacu gguuaaacgg gaaggaguac      960

aagugcaagg ucucgaacaa ggcguuaccg gcgccgaucg agaagacgau cucgaaggcg     1020

aaggggcagc cgcgggagcc gcaggucuac acgcucccgc cgucgcgcga cgaguuaacg     1080

aagaaccagg ucucguuaac gugccucguc aagggguucu acccgucgga caucgcgguc     1140

gagugggagu cgaacgggca gccggagaac aacuacaaga cgacgccgcc ggucuuagac     1200

ucggacgggu cguucuucuu auacucgaag cucacggucg acaagucgcg guggcagcag     1260

gggaacgucu ucucgugcuc ggucaugcac gaggcguuac acaaccacua cacgcagaag     1320

ucguuaucgc ucucgccggg gaaguga                                         1347


<210>  1031
<211>  1347
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Ipilimumab_HC

<400>  1031
caggugcagu uagucgaguc gggcgggggc guggugcagc ccgggcgcuc ccuccgguua       60

ucgugcgccg ccuccggcuu caccuucucg uccuacacca ugcacugggu ccgccaggcg      120

ccggggaagg gcuuagagug ggugacguuc aucucguacg acggcaacaa caaguacuac      180

gccgacuccg ugaaggggcg guucaccauc ucgcgcgaca acuccaagaa cacccucuac      240

uuacagauga acucguuacg ggccgaggac accgccaucu acuacugcgc ccgcacgggc      300

uggcucgggc ccuucgacua cuggggccag gggaccuuag ucaccguguc cucggcgucc      360

accaagggcc ccucgguguu ccccuuagcc ccguccucga aguccacguc gggcgggacc      420

gccgcccucg gcugcuuagu caaggacuac uuccccgagc ccgugaccgu guccuggaac      480

ucgggggcgu uaaccucggg cguccacacg uuccccgccg ugcuccaguc cucgggcuua      540

uacuccuuau cguccguggu caccgugccg ucguccucgc ucgggaccca gaccuacauc      600

ugcaacguga accacaagcc cuccaacacg aaggucgaca agcgggugga gcccaagucg      660

ugcgacaaga cccacacgug cccgccgugc ccggcgccgg aguuauuagg ggggccgucg      720

gucuuccucu ucccgccgaa gccgaaggac acguuaauga ucucgcgcac gccggagguc      780

acgugcgucg ucgucgacgu cucgcacgag gacccggagg ucaaguucaa cugguacguc      840

gacggggucg agguccacaa cgcgaagacg aagccgcggg aggagcagua caacucgacg      900

uaccgcgucg ucucggucuu aacgguccuc caccaggacu gguuaaacgg gaaggaguac      960

aagugcaagg ucucgaacaa ggcguuaccg gcgccgaucg agaagacgau cucgaaggcg     1020

aaggggcagc cgcgggagcc gcaggucuac acgcucccgc cgucgcgcga cgaguuaacg     1080

aagaaccagg ucucguuaac gugccucguc aagggguucu acccgucgga caucgcgguc     1140

gagugggagu cgaacgggca gccggagaac aacuacaaga cgacgccgcc ggucuuagac     1200

ucggacgggu cguucuucuu auacucgaag cucacggucg acaagucgcg guggcagcag     1260

gggaacgucu ucucgugcuc ggucaugcac gaggcguuac acaaccacua cacgcagaag     1320

ucguuaucgc ucucgccggg gaaguga                                         1347


<210>  1032
<211>  1347
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Ipilimumab_HC

<400>  1032
caggugcagu uagucgaguc gggcgggggc guggugcagc ccgggcgcuc ccuccgguua       60

ucgugcgccg ccuccggcuu caccuucucg uccuacacca ugcacugggu ccgccaggcg      120

ccggggaagg gcuuagagug ggugacguuc aucucguacg acggcaacaa caaguacuac      180

gccgacuccg ugaaggggcg guucaccauc ucgcgcgaca acuccaagaa cacccucuac      240

uuacagauga acucguuacg ggccgaggac accgccaucu acuacugcgc ccgcacgggc      300

uggcucgggc ccuucgacua cuggggccag gggaccuuag ucaccguguc cucggcgucc      360

accaagggcc ccucgguguu ccccuuagcc ccguccucga aguccacguc gggcgggacc      420

gccgcccucg gcugcuuagu caaggacuac uuccccgagc ccgugaccgu guccuggaac      480

ucgggggcgu uaaccucggg cguccacacg uuccccgccg ugcuccaguc cucgggcuua      540

uacuccuuau cguccguggu caccgugccg ucguccucgc ucgggaccca gaccuacauc      600

ugcaacguga accacaagcc cuccaacacg aaggucgaca agcgggugga gcccaagucg      660

ugcgacaaga cccacacgug cccgcccugc cccgcccccg aguuauuagg cgggcccucc      720

gucuuccucu ucccgccgaa gccgaaggac acguuaauga ucucgcgcac gccggagguc      780

acgugcgucg ucgucgacgu cucgcacgag gacccggagg ucaaguucaa cugguacguc      840

gacggggucg agguccacaa cgcgaagacg aagccgcggg aggagcagua caacucgacg      900

uaccgcgucg ucucggucuu aacgguccuc caccaggacu gguuaaacgg gaaggaguac      960

aagugcaagg ucucgaacaa ggcguuaccg gcgccgaucg agaagacgau cucgaaggcg     1020

aaggggcagc cgcgggagcc gcaggucuac acgcucccgc cgucgcgcga cgaguuaacg     1080

aagaaccagg ucucguuaac gugccucguc aagggguucu acccgucgga caucgcgguc     1140

gagugggagu cgaacgggca gccggagaac aacuacaaga cgacgccgcc ggucuuagac     1200

ucggacgggu cguucuucuu auacucgaag cucacggucg acaagucgcg guggcagcag     1260

gggaacgucu ucucgugcuc ggucaugcac gaggcguuac acaaccacua cacgcagaag     1320

ucguuaucgc ucucgccggg gaaguga                                         1347


<210>  1033
<211>  1347
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Ipilimumab_HC

<400>  1033
caggugcagu uagucgaguc gggcgggggc guggugcagc ccgggcgcuc ccuccgguua       60

ucgugcgccg ccuccggcuu caccuucucg uccuacacca ugcacugggu ccgccaggcg      120

ccggggaagg gcuuagagug ggugacguuc aucucguacg acggcaacaa caaguacuac      180

gccgacuccg ugaaggggcg guucaccauc ucgcgcgaca acuccaagaa cacccucuac      240

uuacagauga acucguuacg ggccgaggac accgccaucu acuacugcgc ccgcacgggc      300

uggcucgggc ccuucgacua cuggggccag gggaccuuag ucaccguguc cucggcgucc      360

accaagggcc ccucgguguu ccccuuagcc ccguccucga aguccacguc gggcgggacc      420

gccgcccucg gcugcuuagu caaggacuac uuccccgagc ccgugaccgu guccuggaac      480

ucgggggcgu uaaccucggg cguccacacg uuccccgccg ugcuccaguc cucgggcuua      540

uacuccuuau cguccguggu caccgugccg ucguccucgc ucgggaccca gaccuacauc      600

ugcaacguga accacaagcc cuccaacacg aaggucgaca agcgggugga gcccaagucg      660

ugcgacaaga cccacacgug cccgcccugc cccgcccccg aguuauuagg cgggcccucc      720

guguuccucu ucccgcccaa gcccaaggac accuuaauga ucucgcgcac ccccgaggug      780

acgugcgucg ucgucgacgu cucgcacgag gacccggagg ucaaguucaa cugguacguc      840

gacggggucg agguccacaa cgcgaagacg aagccgcggg aggagcagua caacucgacg      900

uaccgcgucg ucucggucuu aacgguccuc caccaggacu gguuaaacgg gaaggaguac      960

aagugcaagg ucucgaacaa ggcguuaccg gcgccgaucg agaagacgau cucgaaggcg     1020

aaggggcagc cgcgggagcc gcaggucuac acgcucccgc cgucgcgcga cgaguuaacg     1080

aagaaccagg ucucguuaac gugccucguc aagggguucu acccgucgga caucgcgguc     1140

gagugggagu cgaacgggca gccggagaac aacuacaaga cgacgccgcc ggucuuagac     1200

ucggacgggu cguucuucuu auacucgaag cucacggucg acaagucgcg guggcagcag     1260

gggaacgucu ucucgugcuc ggucaugcac gaggcguuac acaaccacua cacgcagaag     1320

ucguuaucgc ucucgccggg gaaguga                                         1347


<210>  1034
<211>  1347
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Ipilimumab_HC

<400>  1034
caggugcagu uagucgaguc gggcgggggc guggugcagc ccgggcgcuc ccuccgguua       60

ucgugcgccg ccuccggcuu caccuucucg uccuacacca ugcacugggu ccgccaggcg      120

ccggggaagg gcuuagagug ggugacguuc aucucguacg acggcaacaa caaguacuac      180

gccgacuccg ugaaggggcg guucaccauc ucgcgcgaca acuccaagaa cacccucuac      240

uuacagauga acucguuacg ggccgaggac accgccaucu acuacugcgc ccgcacgggc      300

uggcucgggc ccuucgacua cuggggccag gggaccuuag ucaccguguc cucggcgucc      360

accaagggcc ccucgguguu ccccuuagcc ccguccucga aguccacguc gggcgggacc      420

gccgcccucg gcugcuuagu caaggacuac uuccccgagc ccgugaccgu guccuggaac      480

ucgggggcgu uaaccucggg cguccacacg uuccccgccg ugcuccaguc cucgggcuua      540

uacuccuuau cguccguggu caccgugccg ucguccucgc ucgggaccca gaccuacauc      600

ugcaacguga accacaagcc cuccaacacg aaggucgaca agcgggugga gcccaagucg      660

ugcgacaaga cccacacgug cccgcccugc cccgcccccg aguuauuagg cgggcccucc      720

guguuccucu ucccgcccaa gcccaaggac accuuaauga ucucgcgcac ccccgaggug      780

accugcgucg uggucgacgu gucccacgag gacccggagg ucaaguucaa cugguacgug      840

gacggcgugg agguccacaa cgcgaagacg aagccgcggg aggagcagua caacucgacg      900

uaccgcgucg ucucggucuu aacgguccuc caccaggacu gguuaaacgg gaaggaguac      960

aagugcaagg ucucgaacaa ggcguuaccg gcgccgaucg agaagacgau cucgaaggcg     1020

aaggggcagc cgcgggagcc gcaggucuac acgcucccgc cgucgcgcga cgaguuaacg     1080

aagaaccagg ucucguuaac gugccucguc aagggguucu acccgucgga caucgcgguc     1140

gagugggagu cgaacgggca gccggagaac aacuacaaga cgacgccgcc ggucuuagac     1200

ucggacgggu cguucuucuu auacucgaag cucacggucg acaagucgcg guggcagcag     1260

gggaacgucu ucucgugcuc ggucaugcac gaggcguuac acaaccacua cacgcagaag     1320

ucguuaucgc ucucgccggg gaaguga                                         1347


<210>  1035
<211>  1347
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Ipilimumab_HC

<400>  1035
caggugcagu uagucgaguc gggcgggggc guggugcagc ccgggcgcuc ccuccgguua       60

ucgugcgccg ccuccggcuu caccuucucg uccuacacca ugcacugggu ccgccaggcg      120

ccggggaagg gcuuagagug ggugacguuc aucucguacg acggcaacaa caaguacuac      180

gccgacuccg ugaaggggcg guucaccauc ucgcgcgaca acuccaagaa cacccucuac      240

uuacagauga acucguuacg ggccgaggac accgccaucu acuacugcgc ccgcacgggc      300

uggcucgggc ccuucgacua cuggggccag gggaccuuag ucaccguguc cucggcgucc      360

accaagggcc ccucgguguu ccccuuagcc ccguccucga aguccacguc gggcgggacc      420

gccgcccucg gcugcuuagu caaggacuac uuccccgagc ccgugaccgu guccuggaac      480

ucgggggcgu uaaccucggg cguccacacg uuccccgccg ugcuccaguc cucgggcuua      540

uacuccuuau cguccguggu caccgugccg ucguccucgc ucgggaccca gaccuacauc      600

ugcaacguga accacaagcc cuccaacacg aaggucgaca agcgggugga gcccaagucg      660

ugcgacaaga cccacacgug cccgcccugc cccgcccccg aguuauuagg cgggcccucc      720

guguuccucu ucccgcccaa gcccaaggac accuuaauga ucucgcgcac ccccgaggug      780

accugcgucg uggucgacgu gucccacgag gacccggagg ucaaguucaa cugguacgug      840

gacggcgugg agguccacaa cgccaagacc aagccccggg aggagcagua caacucgacc      900

uaccgcgugg ugucggucuu aacgguccuc caccaggacu gguuaaacgg gaaggaguac      960

aagugcaagg ucucgaacaa ggcguuaccg gcgccgaucg agaagacgau cucgaaggcg     1020

aaggggcagc cgcgggagcc gcaggucuac acgcucccgc cgucgcgcga cgaguuaacg     1080

aagaaccagg ucucguuaac gugccucguc aagggguucu acccgucgga caucgcgguc     1140

gagugggagu cgaacgggca gccggagaac aacuacaaga cgacgccgcc ggucuuagac     1200

ucggacgggu cguucuucuu auacucgaag cucacggucg acaagucgcg guggcagcag     1260

gggaacgucu ucucgugcuc ggucaugcac gaggcguuac acaaccacua cacgcagaag     1320

ucguuaucgc ucucgccggg gaaguga                                         1347


<210>  1036
<211>  1347
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Ipilimumab_HC

<400>  1036
caggugcagu uagucgaguc gggcgggggc guggugcagc ccgggcgcuc ccuccgguua       60

ucgugcgccg ccuccggcuu caccuucucg uccuacacca ugcacugggu ccgccaggcg      120

ccggggaagg gcuuagagug ggugacguuc aucucguacg acggcaacaa caaguacuac      180

gccgacuccg ugaaggggcg guucaccauc ucgcgcgaca acuccaagaa cacccucuac      240

uuacagauga acucguuacg ggccgaggac accgccaucu acuacugcgc ccgcacgggc      300

uggcucgggc ccuucgacua cuggggccag gggaccuuag ucaccguguc cucggcgucc      360

accaagggcc ccucgguguu ccccuuagcc ccguccucga aguccacguc gggcgggacc      420

gccgcccucg gcugcuuagu caaggacuac uuccccgagc ccgugaccgu guccuggaac      480

ucgggggcgu uaaccucggg cguccacacg uuccccgccg ugcuccaguc cucgggcuua      540

uacuccuuau cguccguggu caccgugccg ucguccucgc ucgggaccca gaccuacauc      600

ugcaacguga accacaagcc cuccaacacg aaggucgaca agcgggugga gcccaagucg      660

ugcgacaaga cccacacgug cccgcccugc cccgcccccg aguuauuagg cgggcccucc      720

guguuccucu ucccgcccaa gcccaaggac accuuaauga ucucgcgcac ccccgaggug      780

accugcgucg uggucgacgu gucccacgag gacccggagg ucaaguucaa cugguacgug      840

gacggcgugg agguccacaa cgccaagacc aagccccggg aggagcagua caacucgacc      900

uaccgcgugg uguccgucuu aacggugcuc caccaggacu gguuaaacgg gaaggaguac      960

aagugcaagg ugucgaacaa ggccuuaccc gcgcccaucg agaagaccau cucgaaggcg     1020

aaggggcagc cgcgggagcc gcaggucuac acgcucccgc cgucgcgcga cgaguuaacg     1080

aagaaccagg ucucguuaac gugccucguc aagggguucu acccgucgga caucgcgguc     1140

gagugggagu cgaacgggca gccggagaac aacuacaaga cgacgccgcc ggucuuagac     1200

ucggacgggu cguucuucuu auacucgaag cucacggucg acaagucgcg guggcagcag     1260

gggaacgucu ucucgugcuc ggucaugcac gaggcguuac acaaccacua cacgcagaag     1320

ucguuaucgc ucucgccggg gaaguga                                         1347


<210>  1037
<211>  648
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Ipilimumab_LC

<400>  1037
gagaucgugu uaacccaguc gcccggcacc cucuccuuau cgccggggga gcgcgccacg       60

uuauccugcc gggccucgca guccgucggc ucguccuacc ucgcguggua ccagcagaag      120

cccgggcagg cgccccgcuu auuaaucuac ggcgccuucu cgcgggccac cgggaucccc      180

gaccgcuucu ccggcucggg cuccgggacc gacuucaccc ucacgaucuc gcgguuagag      240

ccggaggacu ucgccgugua cuacugccag caguacggcu ccucgcccug gaccuucggg      300

cagggcacca agguggagau caagcgcacc gucgccgccc ccuccguguu caucuucccg      360

cccucggacg agcaguuaaa guccgggacg gccucggugg ucugccucuu aaacaacuuc      420

uacccccggg aggccaaggu gcaguggaag gucgacaacg cguuacaguc ggggaacucg      480

caggagucgg ucacggagca ggacucgaag gacucgacgu acucgcucuc gucgacguua      540

acguuaucga aggcggacua cgagaagcac aaggucuacg cgugcgaggu cacgcaccag      600

gggcucucgu cgccggucac gaagucguuc aaccgcgggg agugcuga                   648


<210>  1038
<211>  648
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Ipilimumab_LC

<400>  1038
gagaucgugu uaacccaguc gcccggcacc cucuccuuau cgccggggga gcgcgccacg       60

uuauccugcc gggccucgca guccgucggc ucguccuacc ucgcguggua ccagcagaag      120

cccgggcagg cgccccgcuu auuaaucuac ggcgccuucu cgcgggccac cgggaucccc      180

gaccgcuucu ccggcucggg cuccgggacc gacuucaccc ucacgaucuc gcgguuagag      240

ccggaggacu ucgccgugua cuacugccag caguacggcu ccucgcccug gaccuucggg      300

cagggcacca agguggagau caagcgcacc gucgccgccc ccuccguguu caucuucccg      360

cccucggacg agcaguuaaa guccgggacg gccucggugg ucugccucuu aaacaacuuc      420

uacccccggg aggccaaggu gcaguggaag guggacaacg cguuacaguc cggcaacucg      480

caggagucgg ucacggagca ggacucgaag gacucgacgu acucgcucuc gucgacguua      540

acguuaucga aggcggacua cgagaagcac aaggucuacg cgugcgaggu cacgcaccag      600

gggcucucgu cgccggucac gaagucguuc aaccgcgggg agugcuga                   648


<210>  1039
<211>  648
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Ipilimumab_LC

<400>  1039
gagaucgugu uaacccaguc gcccggcacc cucuccuuau cgccggggga gcgcgccacg       60

uuauccugcc gggccucgca guccgucggc ucguccuacc ucgcguggua ccagcagaag      120

cccgggcagg cgccccgcuu auuaaucuac ggcgccuucu cgcgggccac cgggaucccc      180

gaccgcuucu ccggcucggg cuccgggacc gacuucaccc ucacgaucuc gcgguuagag      240

ccggaggacu ucgccgugua cuacugccag caguacggcu ccucgcccug gaccuucggg      300

cagggcacca agguggagau caagcgcacc gucgccgccc ccuccguguu caucuucccg      360

cccucggacg agcaguuaaa guccgggacg gccucggugg ucugccucuu aaacaacuuc      420

uacccccggg aggccaaggu gcaguggaag guggacaacg cguuacaguc cggcaacucg      480

caggagucgg ucaccgagca ggacuccaag gacucgaccu acucgcucuc gucgacguua      540

acguuaucga aggcggacua cgagaagcac aaggucuacg cgugcgaggu cacgcaccag      600

gggcucucgu cgccggucac gaagucguuc aaccgcgggg agugcuga                   648


<210>  1040
<211>  648
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Ipilimumab_LC

<400>  1040
gagaucgugu uaacccaguc gcccggcacc cucuccuuau cgccggggga gcgcgccacg       60

uuauccugcc gggccucgca guccgucggc ucguccuacc ucgcguggua ccagcagaag      120

cccgggcagg cgccccgcuu auuaaucuac ggcgccuucu cgcgggccac cgggaucccc      180

gaccgcuucu ccggcucggg cuccgggacc gacuucaccc ucacgaucuc gcgguuagag      240

ccggaggacu ucgccgugua cuacugccag caguacggcu ccucgcccug gaccuucggg      300

cagggcacca agguggagau caagcgcacc gucgccgccc ccuccguguu caucuucccg      360

cccucggacg agcaguuaaa guccgggacg gccucggugg ucugccucuu aaacaacuuc      420

uacccccggg aggccaaggu gcaguggaag guggacaacg cguuacaguc cggcaacucg      480

caggagucgg ucaccgagca ggacuccaag gacucgaccu acucccucuc guccaccuua      540

acguuaucga aggcggacua cgagaagcac aaggucuacg cgugcgaggu cacgcaccag      600

gggcucucgu cgccggucac gaagucguuc aaccgcgggg agugcuga                   648


<210>  1041
<211>  648
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Ipilimumab_LC

<400>  1041
gagaucgugu uaacccaguc gcccggcacc cucuccuuau cgccggggga gcgcgccacg       60

uuauccugcc gggccucgca guccgucggc ucguccuacc ucgcguggua ccagcagaag      120

cccgggcagg cgccccgcuu auuaaucuac ggcgccuucu cgcgggccac cgggaucccc      180

gaccgcuucu ccggcucggg cuccgggacc gacuucaccc ucacgaucuc gcgguuagag      240

ccggaggacu ucgccgugua cuacugccag caguacggcu ccucgcccug gaccuucggg      300

cagggcacca agguggagau caagcgcacc gucgccgccc ccuccguguu caucuucccg      360

cccucggacg agcaguuaaa guccgggacg gccucggugg ucugccucuu aaacaacuuc      420

uacccccggg aggccaaggu gcaguggaag guggacaacg cguuacaguc cggcaacucg      480

caggagucgg ucaccgagca ggacuccaag gacucgaccu acucccucuc guccaccuua      540

acguuaucga aggccgacua cgagaagcac aagguguacg ccugcgaggu gacgcaccag      600

gggcucucgu cgccggucac gaagucguuc aaccgcgggg agugcuga                   648


<210>  1042
<211>  162
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  solPD1

<400>  1042

Met Gln Ile Pro Gln Ala Pro Trp Pro Val Val Trp Ala Val Leu Gln 
1               5                   10                  15      


Leu Gly Trp Arg Pro Gly Trp Phe Leu Ala Leu Leu Val Val Thr Glu 
            20                  25                  30          


Gly Asp Asn Ala Thr Phe Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser 
        35                  40                  45              


Phe Val Leu Asn Trp Tyr Arg Met Ser Pro Ser Asn Gln Thr Asp Lys 
    50                  55                  60                  


Leu Ala Ala Phe Pro Glu Asp Arg Ser Gln Pro Gly Gln Asp Cys Arg 
65                  70                  75                  80  


Phe Arg Val Thr Gln Leu Pro Asn Gly Arg Asp Phe His Met Ser Val 
                85                  90                  95      


Val Arg Ala Arg Arg Asn Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile 
            100                 105                 110         


Ser Leu Ala Pro Lys Ala Gln Ile Lys Glu Ser Leu Arg Ala Glu Leu 
        115                 120                 125             


Arg Val Thr Glu Arg Arg Ala Glu Val Pro Thr Ala His Pro Ser Pro 
    130                 135                 140                 


Ser Pro Arg Pro Ala Gly Gln Pro Glu Phe Arg Gly Gly Gly Ser Gly 
145                 150                 155                 160 


Gly Gly 
        


<210>  1043
<211>  486
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  solPD1

<400>  1043
augcagaucc cccaggcccc guggcccgug gucugggccg ugcugcagcu cggcuggcgc       60

cccggguggu uccuggcgcu gcucgugguc accgagggcg acaacgccac cuucacgugc      120

agcuucucca acaccagcga guccuucgug cugaacuggu accggaugag ccccuccaac      180

cagaccgaca agcuggccgc cuucccggag gaccgcagcc agcccgggca ggacugccgg      240

uuccgcguga cccagcuccc caacggccgg gacuuccaca uguccgucgu gcgcgcccgg      300

cgcaacgaca gcgggacgua ccugugcggc gcgaucuccc uggcccccaa ggcccagauc      360

aaggagagcc uccgggccga gcugcgcgug accgagcggc gcgcggaggu cccgaccgcc      420

caccccuccc ccagcccccg gccggccggc cagcccgagu uccgcggggg cggguccggc      480

gggggc                                                                 486


<210>  1044
<211>  486
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  solPD1

<400>  1044
augcagaucc cccaggcccc cuggcccguc gucugggccg uccuccagcu cggcuggcgc       60

cccggcuggu uccucgcccu ccucgucguc accgagggcg acaacgccac cuucaccugc      120

uccuucucca acaccuccga guccuucguc cucaacuggu accgcauguc ccccuccaac      180

cagaccgaca agcucgccgc cuuccccgag gaccgcuccc agcccggcca ggacugccgc      240

uuccgcguca cccagcuccc caacggccgc gacuuccaca uguccgucgu ccgcgcccgc      300

cgcaacgacu ccggcaccua ccucugcggc gccaucuccc ucgcccccaa ggcccagauc      360

aaggaguccc uccgcgccga gcuccgcguc accgagcgcc gcgccgaggu ccccaccgcc      420

caccccuccc ccuccccccg ccccgccggc cagcccgagu uccgcggcgg cggcuccggc      480

ggcggc                                                                 486


<210>  1045
<211>  486
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  solPD1

<400>  1045
augcagaucc cccaagcccc uuggccagug gucugggcug uucugcagcu cggcuggaga       60

ccgggguggu uccuugcacu guugguggua accgagggag acaacgccac auuuacuugc      120

agcuucucca auacgucuga aucauuugug uuaaacuggu acaggaugag ucccagcaau      180

cagaccgaua agcuggcggc uuucccugag gaccgguccc agccagguca agauugucgc      240

uuucgaguca cacagcuacc caacggccgu gacuuccaca ugucuguggu uagagccagg      300

cggaaugauu cggggacuua ucucugcgga gcaauuucac uggccccuaa agcucagaua      360

aaggaaagcc uucgcgcaga gcugagagug accgaaaggc gggccgaggu cccaacagcu      420

caucccaguc cuuccccacg cccggccggc cagcccgagu uucgaggugg gggaucuggc      480

ggcggg                                                                 486


<210>  1046
<211>  486
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  solPD1

<400>  1046
augcagaucc cccaggcccc cuggcccgug gugugggccg ugcugcagcu gggcuggaga       60

cccggcuggu uccuggcccu gcugguggug accgagggcg acaacgccac cuucaccugc      120

agcuucagca acaccagcga gagcuucgug cugaacuggu acagaaugag ccccagcaac      180

cagaccgaca agcuggccgc cuuccccgag gacagaagcc agcccggcca ggacugcaga      240

uucagaguga cccagcugcc caacggcaga gacuuccaca ugagcguggu gagagccaga      300

agaaacgaca gcggcaccua ccugugcggc gccaucagcc uggcccccaa ggcccagauc      360

aaggagagcc ugagagccga gcugagagug accgagagaa gagccgaggu gcccaccgcc      420

caccccagcc ccagccccag acccgccggc cagcccgagu ucagaggcgg cggcagcggc      480

ggcggc                                                                 486


<210>  1047
<211>  486
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  solPD1

<400>  1047
augcagaucc cccaagcccc uuggccggug gucugggcug uucugcagcu cggcuggaga       60

cccggguggu uccuggcccu ucugguggug accgagggag acaacgcgac auuuacgugc      120

agcuucucca auaccucuga gagcuuuguc cucaacuggu accggauguc cccuucuaau      180

cagacagaua agcuggcugc cuuccccgaa gaccgcagcc agccuggcca agauuguaga      240

uuucggguga cccagcuucc caacgggcgc gacuuccaca uguccguugu gagagcccgg      300

cgcaaugauu cuggaacaua ucugugcggc gcuauuagcc ucgccccuaa agcucagauc      360

aaggaauccc ugagagccga gcugcggguc accgaacgca gagcggaggu gccgacagcc      420

caucccagcc cuucuccccg gccugcuggg cagcccgagu uucgcggagg cggcuccggg      480

ggaggc                                                                 486


<210>  1048
<211>  486
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  solPD1

<400>  1048
augcaaauac cacaagcucc auggccagua guaugggcag uauuacaauu aggauggaga       60

ccaggauggu uuuuagcauu acuaguagua acagaaggag auaaugcaac auuuacaugu      120

aguuuuucaa auacaucaga aucauuugua uuaaauuggu auagaauguc accaucaaau      180

caaacagaua aauuagcagc auuuccagaa gacagaucac aaccaggaca agauugcaga      240

uucagaguaa cacaauuacc aaacggaaga gacuuucaua ugucaguagu aagagcaaga      300

agaaaugacu caggaacuua uuuaugcgga gcaauaucau uagcaccaaa agcacaaaua      360

aaagaaucac uaagagcaga auuaagagua acagaaagaa gagcagaagu ucccacagca      420

cauccaucac caucaccaag accagcagga caaccagaau uuagaggagg aggaucagga      480

ggagga                                                                 486


<210>  1049
<211>  486
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  solPD1

<400>  1049
augcagaucc cccaagcccc auggccggug gucugggcag ugcugcagcu cggcuggagg       60

cccggguggu uccuggccuu gcugguagug accgagggug acaacgcgac uuuuaccugc      120

agcuucucca auacgaguga auccuuuguc cucaacuggu accggauguc cccaaguaau      180

cagacugaua agcuggccgc auuccccgag gaccgcagcc agccaggcca agauuguagg      240

uuucggguga cccaguugcc caacgggcgc gacuuccaca uguccguggu cagggcccgg      300

cgcaaugaua gcggcaccua ucugugcggu gcaauuuccc ucgccccaaa agcgcagauc      360

aaggaaaguc ugagggccga gcugcgggug acugaacgca gggcagaggu accgaccgcc      420

caucccagcc caagcccccg gccagccggg cagcccgagu uucgcggcgg cgggagcggu      480

ggcggg                                                                 486


<210>  1050
<211>  486
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  solPD1

<400>  1050
augcaaaucc cacaagcccc auggcccguc gucugggccg uccuccaacu cggcuggcgc       60

ccaggcuggu uccuagcacu ccuagucguc accgaaggcg acaacgcaac cuucaccugc      120

uccuucucca acaccucaga aucauucguc cucaacuggu accgcauguc ccccuccaac      180

caaaccgaca aacucgcagc cuuccccgaa gacagaucac aacccggcca agacugcaga      240

uuccgcguca cccaacuccc caacggacgc gacuuccaca uguccguagu ccgcgcccgc      300

cgaaacgacu ccggcaccua ccuaugcggc gccaucucac ucgccccaaa agcacaaauc      360

aaagaaucac ucagagcaga acuacgaguc accgaaagac gcgcagaagu accaaccgcc      420

cacccauccc ccucaccccg acccgccggc caacccgaau uccgcggagg cggcuccggc      480

ggcggc                                                                 486


<210>  1051
<211>  486
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  solPD1

<400>  1051
augcaaaucc cacaagcccc cuggcccguc gucugggccg uacuacaacu cggauggcga       60

cccggcuggu uccuagcccu ccuagucguc accgaaggcg acaacgccac cuucaccugc      120

uccuucucaa acacauccga aucauucguc cucaacuggu accgcauguc ccccuccaac      180

caaaccgaca aacucgccgc cuuccccgaa gaccgauccc aacccggcca agacugccga      240

uuccgcguca cccaacuacc caacggccgc gacuuccaca uguccgucgu ccgcgcccgc      300

cgcaacgacu caggcaccua ccucuguggc gccaucuccc ucgcaccaaa agcccaaauc      360

aaagaauccc uccgcgccga acuccgcguc acagaacgca gagccgaagu ccccaccgca      420

cacccaucac cauccccccg cccagccggc caacccgaau uccgcggagg cggauccggc      480

ggcgga                                                                 486


<210>  1052
<211>  486
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  solPD1

<400>  1052
augcaaaucc cccaagcccc auggcccguc gucugggccg uccuacaacu cggcuggcgc       60

cccggcuggu uccucgcccu ccucgucguc accgaaggcg acaacgccac cuucaccugc      120

uccuucucca acacaucaga auccuucguc cucaacuggu accgaauguc ccccucaaac      180

caaaccgaca aacucgccgc cuuccccgaa gaccgcuccc aacccggcca agacugccgc      240

uuccgaguca cccaacuacc caacggccgc gacuuccaca uguccgucgu ccgcgcccgc      300

cgcaacgacu ccggcaccua ccuaugcggc gccaucuccc ucgcccccaa agcccaaauc      360

aaagaaucac uccgcgccga acuccgcguc accgaacgcc gcgccgaagu ccccaccgcc      420

caccccuccc ccuccccccg ccccgccgga caacccgaau uccgcggcgg cggaucaggc      480

ggcggc                                                                 486


<210>  1053
<211>  486
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  solPD1

<400>  1053
augcaaauac cacaagcacc auggccugua guaugggcag uauuacaauu aggauggaga       60

ccaggauggu uuuuagcacu auuaguagua acagaaggag auaaugcaac auuuacaugu      120

ucauuuagua auacaucaga aucauuugua uuaaauuggu auagaaugag uccaaguaau      180

caaacagaua aauuagcagc auuuccagaa gacagaagcc aaccaggaca agauuguaga      240

uuuagaguaa cacaauuacc aaauggaaga gauuuucaua ugaguguagu aagagcaaga      300

agaaaugacu caggaacaua ucuaugcgga gcaauaagcu uagcaccaaa agcacaaaua      360

aaagaaagcu uaagagcaga auuaagagua acagaaagaa gagcagaagu accaacagca      420

cauccaaguc caaguccaag accagcagga caaccagaau uuagaggagg aggaaguggg      480

ggagga                                                                 486


<210>  1054
<211>  486
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  solPD1

<400>  1054
augcaaauac cacaagcacc auggccagua guaugggcag uauuacaauu aggauggaga       60

ccaggauggu uuuuagcacu acuaguagua acagaaggag auaaugcaac auuuacaugu      120

ucauuuucaa auacaucaga aucauuugua cuaaauuggu auagaauguc accaucaaau      180

caaacagaca aacuagcagc auuuccagaa gacagaucac aaccaggaca agauugcaga      240

uucagaguaa cacaacuacc aaauggaaga gacuuucaua ugucaguagu aagagcaaga      300

agaaaugauu caggaacaua ucuaugugga gcaauaucau uagcuccaaa agcacaaaua      360

aaagaaucau uaagagcaga auuaagagua acagaaagaa gagcagaagu accaacagca      420

cauccaucac caagcccaag accagcagga caaccagaau uuagaggagg aggaucagga      480

ggagga                                                                 486


<210>  1055
<211>  547
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  R3630_SalI

<400>  1055
gggagaaagc ucaagcuuau ccaaguaggc uggucaccug uacaacguag ccgguauuuu       60

uuuuuuuuuu uuuuuuuuga ccgucucaag guccaaguua gucugccuau aaaggugcgg      120

auccacagcu gaugaaagac uugugcggua cgguuaaucu ccccuuuuuu uuuuuuuuuu      180

uuuuuaguaa augcgucuac ugaauccagc gaugaugcug gcccagaucu ucgaccacaa      240

gugcauauag uagucaucga gggucgacuu uuuuuuuuuu uuuuuuuuuu uggcccaguu      300

cugagacuuc gcuagagacu acaguuacag cugcaguagu aaccacugcg gcuauugcag      360

gaaaucccgu ucagguuuuu uuuuuuuuuu uuuuuuccgc ucacuaugau uaagaaccag      420

guggaguguc acugcucucg aggucucacg agagcgcucg auacagugcu uggaagaauc      480

uuuuuuuuuu uuuuuuuuuu uugugcgacg aucacagaga acuucuauuc augcaggucu      540

gcucuag                                                                547


<210>  1056
<211>  547
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  R3630_AatII

<400>  1056
gggagaaagc ucaagcuuau ccaaguaggc uggucaccug uacaacguag ccgguauuuu       60

uuuuuuuuuu uuuuuuuuga ccgucucaag guccaaguua gucugccuau aaaggugcgg      120

auccacagcu gaugaaagac uugugcggua cgguuaaucu ccccuuuuuu uuuuuuuuuu      180

uuuuuaguaa augcgucuac ugaauccagc gaugaugcug gcccagaucu ucgaccacaa      240

gugcauauag uagucaucga gggucgccuu uuuuuuuuuu uuuuuuuuuu uggcccaguu      300

cugagacguc gcuagagacu acaguuacag cugcaguagu aaccacugcg gcuauugcag      360

gaaaucccgu ucagguuuuu uuuuuuuuuu uuuuuuccgc ucacuaugau uaagaaccag      420

guggaguguc acugcucucg aggucucacg agagcgcucg auacagugcu uggaagaauc      480

uuuuuuuuuu uuuuuuuuuu uugugcgacg aucacagaga acuucuauuc augcaggucu      540

gcucuag                                                                547


<210>  1057
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CysPeptid CysHis6Arg4His6Cys

<400>  1057

Cys His His His His His His Arg Arg Arg Arg His His His His His 
1               5                   10                  15      


His Cys 
        


<210>  1058
<211>  1632
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  IL12

<400>  1058
augugccacc aacaacucgu caucuccugg uucucccucg ucuuccuagc cuccccacuc       60

gucgccaucu gggaacucaa aaaagacgua uacgucgucg aacucgacug guaccccgac      120

gccccaggag aaauggucgu ccuaaccugc gacacacccg aagaagacgg uaucaccugg      180

acccucgacc aauccuccga aguccuaggc uccggcaaga cccucaccau ccaagucaaa      240

gaauuuggcg acgcaggaca auacaccugu cacaaaggcg gcgaaguccu cagccacagc      300

cuucuccuac uccauaaaaa agaagacggc aucuggucca cugacauccu caaagaccaa      360

aaagaaccca aaaauaaaac cuuccuccgc ugcgaagcca aaaacuacuc cggccgauuc      420

accuguuggu ggcuaaccac aaucagcacc gaccucaccu ucucagucaa auccucccgc      480

ggcucaucug acccccaagg cgucacaugc ggcgccgcca cccucuccgc cgaacgcguc      540

cgcggcgaca acaaagaaua cgaauacucc gucgaauguc aagaagacuc cgccugcccc      600

gccgccgaag aaucacuccc caucgaaguc auggucgacg caguccacaa acucaaauac      660

gaaaacuaca ccuccuccuu cuucauccgc gacauaauaa aacccgaccc acccaaaaac      720

cuccaacuca agccacucaa aaacucccga caagucgaag ucuccuggga guaccccgac      780

accuggucca caccacacuc cuacuucucc cucaccuucu gcguccaagu ccaaggcaaa      840

uccaaacgcg aaaaaaaaga ccgcguuuuc acagacaaaa ccuccgccac aguaauaugc      900

cgcaaaaacg ccuccaucuc cguccgggcc caagaccgcu acuacuccuc cuccuggucc      960

gagugggccu caguccccug cagcggcagc accuccggga gcggcaagcc cggguccggc     1020

gaggggagca ccaagggccg gaaccugccg guggccaccc ccgaccccgg cauguucccc     1080

ugccugcacc acagccagaa ccuccugcgc gccgugucca acaugcugca gaaggcccgg     1140

cagacgcucg aguucuaccc gugcaccagc gaggagaucg accacgagga caucaccaag     1200

gacaagaccu ccacggucga ggccugccug ccccuggagc ucaccaagaa cgagagcugc     1260

cugaacuccc gcgagaccag cuucaucacc aacggguccu gccuggcgag ccggaagacg     1320

uccuucauga uggcccucug ccugagcucc aucuacgagg accugaagau guaccaggug     1380

gaguucaaga ccaugaacgc caagcuccug auggacccca agcgccagau cuuccuggac     1440

cagaacaugc ucgccgugau cgacgagcug augcaggcgc ugaacuucaa cagcgagacc     1500

gucccccaga aguccagccu cgaggagccg gacuucuaca agaccaagau caagcugugc     1560

auccugcucc acgccuuccg gauccgcgcc gugacgaucg accgggugau guccuaccug     1620

aacgccagcu ga                                                         1632


<210>  1059
<211>  984
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  IL12B

<400>  1059
augugccacc aacaacucgu caucuccugg uucucccucg ucuuccuagc cuccccacuc       60

gucgccaucu gggaacucaa aaaagacgua uacgucgucg aacucgacug guaccccgac      120

gccccaggag aaauggucgu cuuaaccugc gacacacccg aagaagacgg uaucaccugg      180

acccucgacc aauccuccga aguccuaggc uccggcaaga cccucaccau ccaagucaaa      240

gaauuuggcg acgcaggaca auacaccugu cacaaaggcg gcgaaguccu cagccacagc      300

cuucuccuac uccauaaaaa agaagacggc aucuggucca cugacauccu caaagaccaa      360

aaagaaccca aaaauaaaac cuuccuccgc ugcgaagcca aaaacuacuc cggccgauuu      420

accuguuggu ggcuaaccac aaucagcacc gaccucaccu ucucagucaa auccucccgc      480

ggcucaucug acccccaagg cgucacaugc ggcgccgcca ccuuauccgc cgaacgcguc      540

cgcggcgaca acaaagaaua cgaauacucc gucgaauguc aagaagauuc cgccugcccc      600

gccgccgaag aaucacuccc caucgaaguc auggucgacg caguccacaa acucaaauac      660

gaaaacuaca ccuccuccuu cuucauccgc gacauaauaa aacccgaccc acccaaaaac      720

cuccaacuca aaccacucaa aaacucccga caagucgaag ucuccuggga guaccccgac      780

accuggucca caccacacuc cuacuucucc cucaccuucu gcguccaagu ccaaggcaaa      840

uccaaacgcg aaaaaaaaga ccgcguuuuc acagacaaaa ccuccgccac aguaauaugc      900

cgcaaaaacg ccuccaucuc cguccgggcc caagaccgcu acuacuccuc cuccuggucc      960

gagugggccu caguccccug cagc                                             984


<210>  1060
<211>  984
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  IL12B

<400>  1060
augugccacc aacaacucgu caucuccugg uucucccucg ucuuccuagc cuccccacuc       60

gucgccaucu gggaacucaa aaaagacgua uacgucgucg aacucgacug guaccccgac      120

gccccaggag aaauggucgu ccuaaccugc gacacacccg aagaagacgg uaucaccugg      180

acccucgacc aauccuccga aguccuaggc uccggcaaga cccucaccau ccaagucaaa      240

gaauuuggcg acgcaggaca auacaccugu cacaaaggcg gcgaaguccu cagccacagc      300

cuucuccuac uccauaaaaa agaagacggc aucuggucca cugacauccu caaagaccaa      360

aaagaaccca aaaauaaaac cuuccuccgc ugcgaagcca aaaacuacuc cggccgauuc      420

accuguuggu ggcuaaccac aaucagcacc gaccucaccu ucucagucaa auccucccgc      480

ggcucaucug acccccaagg cgucacaugc ggcgccgcca cccucuccgc cgaacgcguc      540

cgcggcgaca acaaagaaua cgaauacucc gucgaauguc aagaagacuc cgccugcccc      600

gccgccgaag aaucacuccc caucgaaguc auggucgacg caguccacaa acucaaauac      660

gaaaacuaca ccuccuccuu cuucauccgc gacauaauaa aacccgaccc acccaaaaac      720

cuccaacuca agccacucaa aaacucccga caagucgaag ucuccuggga guaccccgac      780

accuggucca caccacacuc cuacuucucc cucaccuucu gcguccaagu ccaaggcaaa      840

uccaaacgcg aaaaaaaaga ccgcguuuuc acagacaaaa ccuccgccac aguaauaugc      900

cgcaaaaacg ccuccaucuc cguccgggcc caagaccgcu acuacuccuc cuccuggucc      960

gagugggccu caguccccug cagc                                             984


<210>  1061
<211>  984
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  IL12B

<400>  1061
augugccacc aacaacucgu caucuccugg uucucccucg ucuuccuagc cuccccacuc       60

gucgccaucu gggaacucaa aaaagacgua uacgucgucg aacucgacug guaccccgac      120

gccccaggag aaauggucgu ccuaaccugc gacacacccg aagaagacgg uaucaccugg      180

acccucgacc aauccuccga aguccuaggc uccggcaaga cccucaccau ccaagucaaa      240

gaauuuggcg acgcaggaca auacaccugu cacaaaggcg gcgaaguccu cagccacagc      300

cuucuccuac uccauaaaaa agaagacggc aucuggucca cugacauccu caaagaccaa      360

aaagaaccca aaaauaaaac cuuccuccgc ugcgaagcca aaaacuacuc cggccgauuc      420

accuguuggu ggcuaaccac aaucagcacc gaccucaccu ucucagucaa auccucccgc      480

ggcucaucug acccccaagg cgucacaugc ggcgccgcca cccucuccgc cgaacgcguc      540

cgcggcgaca acaaagaaua cgaauacucc gucgaauguc aagaagacuc cgccugcccc      600

gccgccgaag aaucacuccc caucgaaguc auggucgacg caguccacaa acucaaauac      660

gaaaacuaca ccuccuccuu cuucauccgc gacauaauaa aacccgaccc acccaaaaac      720

cuccaacuca agccacucaa aaacucccga caagucgaag ucuccuggga guaccccgac      780

accuggucca caccacacuc cuacuucucc cucaccuucu gcguccaagu ccaaggcaaa      840

uccaaacgcg aaaaaaaaga ccgcguuuuc acagacaaaa ccuccgccac aguaauaugc      900

cgcaaaaacg ccuccaucuc cguccgggcc caagaccgcu acuacuccuc cuccuggucc      960

gagugggccu caguccccug cagc                                             984


<210>  1062
<211>  984
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  IL12B

<400>  1062
augugccacc aacaacucgu caucuccugg uucucccucg ucuuccuagc cuccccacuc       60

gucgccaucu gggaacucaa aaaagacgua uacgucgucg aacucgacug guaccccgac      120

gccccaggag aaauggucgu ccuaaccugc gacacacccg aagaagacgg uaucaccugg      180

acccucgacc aauccuccga aguccuaggc uccggcaaga cccucaccau ccaagucaaa      240

gaauuuggcg acgcaggaca auacaccugu cacaaaggcg gcgaaguccu cagccacagc      300

cuucuccuac uccauaaaaa agaagacggc aucuggucca cugacauccu caaagaccaa      360

aaagaaccca aaaauaaaac cuuccuccgc ugcgaagcca aaaacuacuc cggccgauuc      420

accuguuggu ggcuaaccac aaucagcacc gaccucaccu ucucagucaa auccucccgc      480

ggcucaucug acccccaagg cgucacaugc ggcgccgcca cccucuccgc cgaacgcguc      540

cgcggcgaca acaaagaaua cgaauacucc gucgaauguc aagaagacuc cgccugcccc      600

gccgccgaag aaucacuccc caucgaaguc auggucgacg caguccacaa acucaaauac      660

gaaaacuaca ccuccuccuu cuucauccgc gacauaauaa aacccgaccc acccaaaaac      720

cuccaacuca agccacucaa aaacucccga caagucgaag ucuccuggga guaccccgac      780

accuggucca caccacacuc cuacuucucc cucaccuucu gcguccaagu ccaaggcaaa      840

uccaaacgcg aaaaaaaaga ccgcguuuuc acagacaaaa ccuccgccac aguaauaugc      900

cgcaaaaacg ccuccaucuc cguccgggcc caagaccgcu acuacuccuc cuccuggucc      960

gagugggccu caguccccug cagc                                             984


